Maria Paula Caramez, João Batista Borges, Mauro R. Tucci, Valdelis Novis Okamoto, Carlos Roberto Ribeiro de Carvalho, Robert M. Kacmarek, Atul Malhotra, Irineu Tadeu Velasco, Marcelo B. P. Amato,
Objective: To reevaluate the clinical impact of external positive end-expiratory pressure (external-PEEP) application in patients with severe airway obstruction during controlled mechanical ventilation. The controversial occurrence of a paradoxic lung deflation promoted by PEEP was scrutinized. Design: External-PEEP was applied stepwise (2 cm H2O, 5-min steps) from zero-PEEP to 150% of intrinsic-PEEP in patients already submitted to ventilatory settings minimizing overinflation. Two commonly used ...
Tópico(s): Airway Management and Intubation Techniques
2005 - Lippincott Williams & Wilkins | Critical Care Medicine
Produção Nacional
Revisado por pares
Sônia Maria Beiro Caramez, Marcia A. Stefani, João de Deus Medeiros, Manoela Alano Vieira, Gustavo R. Brüske, Alícia de Francisco, Edna Regina Amante,
ABSTRACT The nutritional value of pumpkin seeds is widely recognized. This article shows that alkaline maceration of pumpkin seed makes them soft and improves their market acceptability as an important source of fiber, unsaturated lipids, minerals and proteins. Microscopic characterization of pumpkin seeds was realized. The results indicate elimination of minerals from the seeds through the delignification process due to the nature of the phenolic compounds eliminated in the maceration liquid. The ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2008 - Wiley | Journal of Food Process Engineering
Produção Nacional
Revisado por pares
João Batista Borges, Valdelis Novis Okamoto, Gustavo Faissol Janot de Matos, Maria Paula Caramez, Paula Ricci Arantes, Fabio Barros, Ciro Eduardo Souza, J.A. Victorino, Robert M. Kacmarek, Carmen Sílvia Valente Barbas, Carlos Roberto Ribeiro de Carvalho, Marcelo B. P. Amato,
Rationale: The hypothesis that lung collapse is detrimental during the acute respiratory distress syndrome is still debatable. One of the difficulties is the lack of an efficient maneuver to minimize it.Objectives: To test if a bedside recruitment strategy, capable of reversing hypoxemia and collapse in > 95% of lung units, is clinically applicable in early acute respiratory distress syndrome.Methods: Prospective assessment of a stepwise maximum-recruitment strategy using multislice computed tomography ...
Tópico(s): Neonatal Respiratory Health Research
2006 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
J.A. Victorino, João Batista Borges, Valdelis Novis Okamoto, Gustavo Faissol Janot de Matos, Mauro R. Tucci, Maria Paula Caramez, Harki Tanaka, Fernando Suárez-Sipmann, Durval C. B. Santos, Carmen Sílvia Valente Barbas, Carlos Roberto Ribeiro de Carvalho, Marcelo B. P. Amato,
Imbalances in regional lung ventilation, with gravity-dependent collapse and overdistention of nondependent zones, are likely associated to ventilator-induced lung injury. Electric impedance tomography is a new imaging technique that is potentially capable of monitoring those imbalances. The aim of this study was to validate electrical impedance tomography measurements of ventilation distribution, by comparison with dynamic computerized tomography in a heterogeneous population of critically ill ...
Tópico(s): Respiratory Support and Mechanisms
2003 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Produção Nacional
Revisado por pares
S. El-Dash, João Batista Borges, Eduardo Leite Vieira Costa, Mauro R. Tucci, Otávio T. Ranzani, Maria Paula Caramez, Carlos Roberto Ribeiro de Carvalho, Marcelo B. P. Amato,
There is debate whether pressure transmission within the lungs and alveolar collapse follow a hydrostatic pattern or the compression exerted by the weight of the heart and the diaphragm causes collapse localized in the areas adjacent to these structures. The second hypothesis proposes the existence of a cephalocaudal gradient in alveolar collapse. We aimed to define whether or not lung density and collapse follow a 'liquid-like' pattern with homogeneous isogravitational layers along the cephalocaudal ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2016 - Wiley | Acta Anaesthesiologica Scandinavica
Produção Nacional
Revisado por pares
Vanessa Neitzke‐Montinelli, Carolina Calôba, Guilherme A. Melo, Bianca B. Frade, Enzo Caramez, Luciano Mazzoccoli, André Nicolau Aquime Gonçalves, Helder I. Nakaya, Renata M. Pereira, Miriam B. F. Werneck, João P. B. Viola,
Long-term immunological protection relies on the differentiation and maintenance of memory lymphocytes. Since the knowledge of memory generation has been centered on in vivo models of infection, there are obstacles to deep molecular analysis of differentiating subsets. Here we defined a novel in vitro CD8 T cell activation and culture regimen using low TCR engagement and cytokines to generate differentiated cells consistent with central memory-like cells, as shown by surface phenotype, gene expression ...
Tópico(s): Immunotherapy and Immune Responses
2022 - Frontiers Media | Frontiers in Immunology
Rafael Ferreira Luciano, João Pedro Vaz de Lima, Vitor Deriquehem, Nathalia Salim Saud, Flavia Zuchen, Erika Alvarenga Caramez, Antonio Carlos Moraes,
Tópico(s): Otolaryngology and Infectious Diseases
2024 - Elsevier BV | The Brazilian Journal of Infectious Diseases