Miguel Melo, Adriana Gaspar da Rocha, João Vinagre, Manuel Sobrinho‐Simões, Paula Soares,
Tópico(s): Clusterin in disease pathology
2015 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Produção Nacional
Revisado por pares
Renato Simões Gaspar, Renata Ohana Alves Benevides, João Lucas de Lima Fontelles, Caroline Castro Vale, Lucas Martins França, Paulo de Tarso Silva Barros, Antonio Marcus de Andrade Paes,
Obesity and metabolic syndrome are the common causes of reproductive and fertility disorders in women. In particular, polycystic ovary syndrome, which is clinically characterized by hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology, has been increasingly associated with metabolic disorders. However, given the broad interplay between metabolic and reproductive functions, this remains a field of intense research. In this study, we investigated the effect of monosodium l-glutamate ( ...
Tópico(s): Regulation of Appetite and Obesity
2016 - Bioscientifica | Journal of Endocrinology
Produção Nacional
Revisado por pares
Ana Henriques Mota, Joana M. Andrade, Maria João Rodrigues, Luísa Custódio, Maria Rosário Bronze, Noélia Duarte, André Rolim Baby, João Rocha, Maria Manuela Gaspar, Sandra Simões, Manuela Carvalheiro, Elias Fattal, António J. Almeida, Catarina Pinto Reis,
Tópico(s): Pomegranate: compositions and health benefits
2020 - Elsevier BV | Industrial Crops and Products
José Cândido de Oliveira Martins,
As cartas trocadas entre Jorge de Sena e João Gaspar Simões, entre 1943 e 1977, mostram-se bastante ricas ...
Tópico(s): Linguistics and Education Research
2022 - University of Minho | Diacrítica
... da obra Elói ou romance numa cabeça de João Gaspar Simões, por meio da qual se observa a influência ...
Tópico(s): Linguistics and Education Research
2018 - | Veredas
Tiago Bordeira Gaspar, Ana Sá, José Manuel Lopes, Manuel Sobrinho‐Simões, Paula Soares, João Vinagre,
Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was generated, and different TMMs were reported and explained in detail, benefiting from genome- ...
Tópico(s): Renal and related cancers
2018 - Multidisciplinary Digital Publishing Institute | Genes
Miguel Melo, Gracinda Costa, Cristina Ribeiro, Francisco Carrilho, Maria João Martins, Adriana Gaspar da Rocha, Manuel Sobrinho‐Simões, Manuela Carvalheiro, Paula Soares,
Thyroglobulin (Tg) levels measured at the time of remnant ablation after thyroid hormone withdrawal (THW) were shown to have prognostic value in predicting disease-free status.Our objectives were to determine whether stimulated Tg levels, measured at the time of remnant ablation performed under recombinant human TSH (rhTSH) stimulation, has value in predicting absence of detectable disease 1 year after radioiodine therapy and to compare the results obtained with this approach with a cohort of patients ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2013 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Tiago Krug, Helena Manso, Liliana Gouveia, João Sobral, Joana M. Xavier, Isabel Soares de Albergaria, Gisela Gaspar, Manuel Correia, Miguel Viana‐Baptista, Rita Moiron Simões, Amélia Nogueira Pinto, Ricardo Taipa, Carla Ferreira, João Ramalho Fontes, Mário Rui Silva, João Paulo Gabriel, Ilda Matos, Gabriela Lopes, José M. Ferro, Astrid M. Vicente, Sofia A. Oliveira,
Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and metabolic phenotypes, but no studies have yet been performed in stroke patients. KALRN is involved, among others, in the inhibition of inducible ...
Tópico(s): Nuclear Receptors and Signaling
2010 - Springer Science+Business Media | Human Genetics
Confesso que a publicação desta correspondência, com um estudo introdutório, organização e notas de Filipe Delfim Santos, me motivou particularmente dado que tive Simões por meu mestre iniciático na crítica literária. Podemos hoje discutir a valia dos seus romances, que muitos foram, do seu teatro,porventura o teor das suas resenhas críticas, que era uma atividade de todo inconsistente até ele a assumir de corpo inteiro. Mas não podemos desconhecer que foi alguém na literatura.
Tópico(s): Brazilian cultural history and politics
2015 - | Metamorfoses - Revista de Estudos Literários Luso-Afro-Brasileiros
Tópico(s): Linguistics and Education Research
1987 - Fundacao Calouste Gulbenkian | Colóquio. Letras
Tópico(s): Literature, Culture, and Criticism
1984 - Fundacao Calouste Gulbenkian | Colóquio. Letras
Tópico(s): Cultural, Media, and Literary Studies
1983 - Fundacao Calouste Gulbenkian | Colóquio. Letras
Produção Nacional
Revisado por pares
Renato Simões Gaspar, Samira Abdalla da Silva, Jennifer Stapleton, João Lucas de Lima Fontelles, Hiran Reis Sousa, Vinicyus Teles Chagas, Shuruq E. Alsufyani, Andrés Trostchansky, Jonathan M. Gibbins, Antonio Marcus de Andrade Paes,
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid. Little is known about the potential anti-platelet properties of S. cumini and its constituent flavonoids. Objective To evaluate the anti-platelet effects and mechanism of action of a polyphenol-rich extract (PESc) from S. cumini leaf and its most prevalent ...
Tópico(s): Calcium signaling and nucleotide metabolism
2020 - Frontiers Media | Frontiers in Pharmacology
Produção Nacional
Revisado por pares
Hiran Reis Sousa, Renato Simões Gaspar, Elyjany Sena, Silvia A. G. Da-Silva, João Lucas de Lima Fontelles, Thaı́s L. S. Araujo, Mauricio Mastrogiovanni, Diana M. Fries, Ana Paula Silva de Azevedo dos Santos, Francisco Rafael Martins Laurindo, Andrés Trostchansky, Antonio Marcus de Andrade Paes,
Essentials Inhibitors of protein disulfide isomerase (PDI) have been considered a new antithrombotic class. CxxC is a PDI-targeted peptide that has been previously shown to inhibit its reductase activity. CxxC binds to surface PDI and inhibits ADP- and thrombin-evoked platelet activation and aggregation. CxxC binds to Cys400 on CGHC redox motif of PDI a' domain, a site for PDI prothrombotic activity.Background Protein disulfide isomerase (PDI) plays a major role in platelet aggregation, and its inhibitors ...
Tópico(s): Blood properties and coagulation
2017 - Elsevier BV | Journal of Thrombosis and Haemostasis
Produção Nacional
... of Lourenço's Pessoan criticism: the psychobiography of João Gaspar Simões; José Augusto Seabra's Barthesian thesis related to ...
Tópico(s): Cultural, Media, and Literary Studies
2024 - | Revista Desassossego
Sílvia Quinteiro, Ana Cláudia Salgueiro Silva,
... Lisboa: Editorial Presença, 1988), 165 (our translation).16 João Gaspar Simões, Perspectiva Histórica de Ficção Portuguesa: Das Origens ao ...
Tópico(s): Travel Writing and Literature
2023 - Taylor & Francis | Journal of Tourism History
Alexandra Rosa, Benedita V. Fonseca, Tiago Krug, Helena Manso, Liliana Gouveia, Isabel Soares de Albergaria, Gisela Gaspar, Manuel Correia, Miguel Viana‐Baptista, Rita Moiron Simões, Amélia Nogueira Pinto, Ricardo Taipa, Carla Ferreira, João Ramalho Fontes, Mário Rui Silva, João Paulo Gabriel, Ilda Matos, Gabriela Lopes, José M. Ferro, Astrid M. Vicente, Sofia A. Oliveira,
Abstract Background The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to assess the contribution of mtDNA polymorphisms and haplogroups to ischemic stroke ...
Tópico(s): Metabolism and Genetic Disorders
2008 - BioMed Central | BMC Medical Genetics
Eduardo Assunção, Pedro Dinis Gaspar, Khadijeh Alibabaei, Maria Paula Simões, Hugo Proença, Vasco N. G. J. Soares, João M. L. P. Caldeira,
Within the scope of precision agriculture, many applications have been developed to support decision making and yield enhancement. Fruit detection has attracted considerable attention from researchers, and it can be used offline. In contrast, some applications, such as robot vision in orchards, require computer vision models to run on edge devices while performing inferences at high speed. In this area, most modern applications use an integrated graphics processing unit (GPU). In this work, we propose ...
Tópico(s): Leaf Properties and Growth Measurement
2022 - Multidisciplinary Digital Publishing Institute | Future Internet
... 1935, to Adolfo Casais Monteiro, partially reproduced in João Gaspar Simões, Vida e Obra de Fernando Pessoa [Amadora [1970]], ... the work thoroughly (Cartas de Fernando Pessoa a João Gaspar Simões [Lisboa [1957]], 75–77. Further, Pessoa translated Crowley' ...
Tópico(s): Health, Education, and Cultural Studies
1982 - Liverpool University Press | Bulletin of Hispanic Studies
João Pires Gaspar, Pedro Dinis Gaspar, Pedro Dinho da Silva, Maria Paula Simões, Christophe Espírito Santo,
Currently, there is a growing demand for cleaner and sustainable technologies due to environmental issues. In this sense, there is a necessity to manage the assessment of production processes and the rationalization of energy consumption. In this study, an Energy Life-Cycle Assessment (ELCA) was carried out through energy efficiency indicators, directed to the characterization and renewability of the peach production system life-cycle in the Portuguese region of Beira Interior. The study intends ...
Tópico(s): Environmental Sustainability in Business
2018 - Multidisciplinary Digital Publishing Institute | Sustainability
Filipe Costa Vaz, João Pedro Tereso, Maria Martín Seijo, Sérgio Simões Pereira, Rita Gaspar, Luís Seabra, José Carlos Sastre Blanco,
The construction of Baixo Sabor Dam (NE Portugal), led to the discovery and excavation of the site of Quinta de Crestelos, with a human occupation ranging from the Early Palaeolithic to mid-20th century. Its Iron Age phase, found at the site's hilltop, revealed an unprecedented large number of combustion structures, comprehending several typologies of ovens and hearths, as well as refuse deposits in which archaeobotanical samples were recovered. Given the number and interpretative importance of these ...
2017 - Elsevier BV | Quaternary International
Pedro Francisco, Mariana Amaral, Afonso Neves, Tânia Ferreira-Gonçalves, Ana S. Viana, José Catarino, Pedro Faísca, Sandra Simões, João Perdigão, M.A.J. Charmier, Maria Manuela Gaspar, Catarina Pinto Reis,
Presently, skin burns are considered one of the main public health problems and lack therapeutic options. In recent years, silver nanoparticles (AgNPs) have been widely studied, playing an increasingly important role in wound healing due to their antibacterial activity. This work is focused on the production and characterization of AgNPs loaded in a Pluronic® F127 hydrogel, as well as assessing its antimicrobial and wound-healing potential. Pluronic® F127 has been extensively explored for therapeutic ...
Tópico(s): Bee Products Chemical Analysis
2023 - Multidisciplinary Digital Publishing Institute | Gels
Catarina Tomás, Emanuel Oliveira, DANIEL WALLACE ASSIS DE SOUSA, Matheus Uba Chupel, Guilherme Eustáquio Furtado, Clara Rocha, Ana Teixeira, Pedro Lopes Ferreira, C. Alves, Stefan Gisin, Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Américo Silva Bonfim, Carina Silva, Débora Franco, Jesús Alcoba González, Maria Helena de Agrela Gonçalves Jardim, Rita Silva, Cristina Lavareda Baixinho, Ma Helena Presado, Ma Fátima Marques, Mário E. Cardoso, Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto, João Frade, Carla Nunes, João R. Mesquita, María Säo José Nascimento, Guilherme Gonçalves, Conceição Castro, Alice Mártires, M. João Monteiro, Conceição Rainho, Francisco P. Caballero, Fátima M. Monago, José T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco Buitrago Ramírez, Andrea Ribeiro, Ana Quelhas, Maria Conceição Manso, Francisco P. Caballero, José T. Guerrero, Fátima M. Monago, Rafael Brito Santos, Nuria R. Jimenez, Cristina G. Nuñez, Inmaculada Rodríguez Gómez, Ma Jose L. Fernandez, Laura A. Marquez, Ana L. Moreno, Ma Jesus Tena Huertas, Francisco Buitrago Ramírez, Daniel Seabra, Ma Céu Salvador, Luciene Muniz Braga, Pedro Parreira, Anabela Salgueiro‐Oliveira, Cristina Arreguy-Sena, Bibiana F. Oliveira, Ma Adriana Henriques, Joana Santos, Sara Lebre, Alda Marques, Clarinda Festas, Sandra Rodrigues, Andrea Ribeiro, José Lumini‐Oliveira, Ana Gabriela Figueiredo, Francisco J. Hernandez-Martinez, Liliana Campi, Ma Pino Quintana-Montesdeoca, Juan F. Jimenez-Diaz, Bienvenida C. Rodriguez-De-Vera, Alexandra Parente, Ma Augusta Mata, Ana Ma Pereira, Adília Fernandes, Manuel Brás, Ma Rosário Pinto, Pedro Parreira, Marta Lima Basto, Ana C. Rei, Lisete Mónico, Gilberta Sousa, Clementina Morna, Otília Freitas, Gregório Freitas, Ana Carolina Gomes Jardim, Rita P. Vasconcelos, Lina G. Horta, Roger dos Santos Rosa, Luís Fernando Kranz, Rita C. Nugem, Mariana Santiago Siqueira, Ronaldo Bordin, Rosiane Kniess, Josimari Telino de Lacerda, Joana Guedes, Idalina Machado, Sidalina Almeida, Adriano Zilhão, Hélder Alves, Óscar Ribeiro, Ana Paula Martins Amaral, Ana Maria Ribeiro dos Santos, Joana Monteiro, Ma Clara Rocha, Rui Cruz, Ana Paula Martins Amaral, Marina Lourenço, Ma Clara Rocha, Rui Cruz, Sandra Regina Masetto Antunes, Verónica Mendonça, Isabel Andrade, Nádia Osório, Ana Valado, Armando Caseiro, Antonio Padua y Gabriel, Anabela Correia Martins, Fernando Mendes, Lídia Cabral, Manuela Ferreira, Amadeu Gonçalves, Tatiana Durão D`Ávila Luz, Leonardo Gomes de Oliveira Luz, Raúl A. Martins, Alice Murteira Morgado, Maria da Luz Vale-Dias, Rui Porta-Nova, Tânia Cristina Malezan Fleig, Éboni Marília Reuter, Miriam Beatris Froemming, Sabrina Luciane Camara Guerreiro, Lisiane Lisbôa Carvalho, Daniel Guedelha, Pedro S. Coelho, A.T. Pereira, António Calha, Raúl Cordeiro, Ana Gonçalves, Ana Certo, Ana Cristina Araújo de Andrade Galvão, Ma Augusta Mata, Aline Welter, Elayne Crestani Pereira, Sandra Aparecida Ribeiro, Márcia Regina Kretzer, Juan-Fernando Jiménez-Díaz, Carla Jiménez-Rodríguez, Francisco-José Hernández-Martínez, Bienvenida-Del-Carmen Rodríguez-De-Vera, Alexandre Marques-Rodrigues, Patrícia Brazil Pereira Coelho, Tiago Bernardes, Alexandre de Araújo Pereira, Patrícia Sousa, João Ghizzo Filho, Nazaré Otília Nazário, Márcia Regina Kretzer, Odete Amaral, António Garrido, Nélio Veiga, Carla Nunes, Ana Rita Pedro, Carlos Pereira, António Almeia, Hélder Miguel Fernandes, Carlos Vasconcelos, Nélson Sousa, Víctor Machado Reis, M. João Monteiro, Romeu Mendes, Isabel Pinto, Tânia C. S. P. Pires, João Gama, Vera Preto, Norberto Silva, Carlos Pires Magalhães, Matilde Martins, Mafalda Duarte, Constança Paúl, Ignácio Martín, Arminda Pinheiro, S. Xavier, J. Azevedo, E. Bento, C. Marques, M. Marques, A. Macedo, A.T. Pereira, José Pedro Almeida, António Almeida, Josiane Alves, Nélson Sousa, Francisco Saavedra, Romeu Mendes, Ana S. Maia, Michelle Teixeira Oliveira, Anderson Reis de Sousa, Paulo P. Ferreira, Luci S. Lopes, Eujcely C. Santiago, Sílvia Monteiro, Ângelo Jesus, Armanda Colaço, Antônio Ivo de Carvalho, Rita P. Silva, Agostinho Cruz, Ana Ferreira, Catarina Marques, João Paulo Figueiredo, Susana Paix�ão, Ana Ferreira, Carla Lopes, Fernando Moreira, João Paulo Figueiredo, Ana Ferreira, Diana Ribeiro, Fernando Moreira, João Paulo Figueiredo, Susana Paix�ão, Telma Fernandes, Diogo Amado, Jéssica Denise Vieira Leal, Marcelo Costa Velho Mendes de Azevedo, Sónia Ramalho, Catarina Mangas, Jaime Ribeiro, Rita Maria de Abreu Gonçalves, Amélia Fernandes Nunes, Ana Rita Tuna, Carlos Martins, Henriqueta D. Forte, Cláudia Costa, José António Tenedório, Paula Santana, José Augusto Andrade, Joana Pinto, C. Campofiorito, S. C. Nunes, Ana Sofia Carmo, A. Kaliniczenco, BARBARA DE LIMA ALVES, Francisco Mendes, Carlos Jesus, Felipe Paiva Fonseca, Flávia de Sousa Gehrke, Carlos Albuquerque, Rita Carla Pereira Batista, Madalena Cunha, António Dias, Olivério Ribeiro, Rosa Maria Grangeiro Martins, Teresa Madeira, Catarina Peixoto-Plácido, Nuno Rebelo dos Santos, Osvaldo Santos, Astrid Bergland, Asta Bye, Carla Lopes, Violeta Alarcão, Beatriz Goulão, Nuno Mendonça, Paulo Nicola, J. Gorjão Clara, João Gomes, Ana Querido, Catarina Tomás, Daniel Carvalho, Marina Cordeiro, Marlene Rosa, Alda Marques, Daniela Brandão, Óscar Ribeiro, Lia Araújo, Constança Paúl, Beatriz Minghelli, Sylvina Richaud, Ana Laura Mendes, Joana Marta‐Simões, Inês A. Trindade, Cláudia Ferreira, Teresa Carvalho,
... Spina Bifida: A pilot study Isabel Malheiro, Filomena Gaspar, Luísa Barros O95 Influence of chair-based yoga exercises on salivary anti-microbial proteins in institutionalized frail-elderly women: a preliminary study Guilherme Furtado, Mateus Uba-Chupel, Mariana Marques, Luís Rama, Margarida Braga, José P. Ferreira, Ana Mª Teixeira O96 High intensity interval training vs moderate intensity continuous training impact on diabetes 2 João Cruz, Tiago Barbosa, Ângela Simões, Luís Coelho O97 Family caregiver of people with ...
BioMed Central
Maria João Gaspar, Cândida Sofia Trindade, Ana Usié, Brígida Meireles, Ana Margarida Fortes, Joana Bagoin Guimarães, Fernanda Simões, Rita Costa, A. M. Ramos,
Pine wilt disease (PWD) caused by pine wood nematode (PWN), Bursaphelenchus xylophilus, is a serious threat to global forest populations of conifers, in particular Pinus spp. Recently, the presence of PWN was reported in dead Yunnan pine (Pinus yunnanensis) trees under natural conditions. To further understand the potential impact caused by PWN in Yunnan pine populations, a transcriptional profiling analysis was performed over different time points (0 hours (h), 6 h, 24 h, 48 h, and 7 days) after PWN ...
Tópico(s): Insect-Plant Interactions and Control
2020 - Multidisciplinary Digital Publishing Institute | Forests
Nuno A. Fonseca, Ana C. Gregório, Vera M. Mendes, Rui M. Lopes, Teresa R. Abreu, Nélio Gonçalves, Bruno Manadas, Manuela Lacerda, Paulo Figueiredo, Marta Pereira, Maria Manuela Gaspar, Fabiana Colelli, Daniela Pesce, Giacomo Signorino, Laura Focareta, Alessandra Fucci, Francesco Cardile, Claudio Pisano, Tony F. Cruz, Luís Almeida, Vera Moura, Sérgio Simões, João Nuno Moreira,
Patients with breast or ovarian cancer have not benefited from improved efficacy with pegylated liposomal doxorubicin relative to free drug, likely due to the limited extent of the enhanced permeability and retention (EPR) effect, further compromising drug bioavailability in the tumor. Herein it is hypothesized that targeting nucleolin overexpressed in tumor endothelial cells (readily accessible from the vascular compartment), besides cancer cells, with PEGASEMP (doxorubicin hydrochloride in a lipid- ...
Tópico(s): RNA Interference and Gene Delivery
2021 - Elsevier BV | Nano Today
... a tradução portuguesa do referido Journal (realizada por João Gaspar Simões e revista para a 2ª edição de 1983) ...
Tópico(s): Caribbean history, culture, and politics
2019 - | MODOS Revista de História da Arte
Produção Nacional
Revisado por pares
Maria Aparecida Barbosa, João Marcos da Silva,
... Caeiro. Fernando Pessoa. (Nota explicativa e notas de João Gaspar Simões e Luiz de Montalvor.) 10. ed. Lisboa: Ática, ...
Tópico(s): Literature, Culture, and Criticism
2019 - | IPOTESI – REVISTA DE ESTUDOS LITERÁRIOS
... obra de Julio Dinis (Lisbon: Biblioteca Breve,1979). Joäo Gaspar Simöes,PespectivaHistóricada Ficçâo Portuguesadas Origensao Seculo XX (Lisbon: DomQuixote, ...
Tópico(s): Cultural, Media, and Literary Studies
2003 - Modern Humanities Research Association | Portuguese Studies
João Bartolomeu Rodrigues, André Ribeiro,
... e Presença, de Miguel Torga, José Régio e João Gaspar Simões.
Tópico(s): Cultural, Media, and Literary Studies
2020 - | ERAS | European Review of Artistic Studies
... 16. For a conventional twentieth-century judgement, see João Gaspar Simões, História da poesia portuguesa, 2 vols (Lisbon: Empresa ...
Tópico(s): Historical and Literary Analyses
1986 - Liverpool University Press | Bulletin of Hispanic Studies