... 10.1287/opre.2020.2062Filippo Balestrieri, Sergei Izmalkov, Joao Leao The Market for Surprises: Selling Substitute Goods Through ...
Tópico(s): Corporate Governance and Law
1963 - University of Chicago Press | The Supreme Court Review
Produção Nacional
Revisado por pares
Emily De Conto, Úrsula da Silveira Matte, João Paolo Bilibio, Vanessa Krebs Genro, Carlos Augusto Bastos de Souza, Delva Pereira Leão, João Sabino Cunha‐Filho,
The purpose of this paper is to determine whether there is a correlation between polymorphisms in the growth differentiation factor-9 (GDF-9) gene and anti-Müllerian hormone (AMH) gene and its receptor, AMHR2, and endometriosis-associated infertility.This is a case-control study to evaluate whether there is a correlation between polymorphisms in the GDF-9 gene (SNPs determined by direct sequencing), AMH gene, AMHR2 (both SNPs determined by genotyping using TaqMan Allelic Discrimination), and endometriosis- ...
Tópico(s): Ovarian function and disorders
2017 - Springer Science+Business Media | Journal of Assisted Reproduction and Genetics
Produção Nacional
Revisado por pares
Jorge W. D. Leão, João B. C. Silva,
We present a new approach to perform any linear transformation of gridded potential field data using the equivalent‐layer principle. It is particularly efficient for processing areas with a large amount of data. An N × N data window is inverted using an M × M equivalent layer, with M greater than N so that the equivalent sources extend beyond the data window. Only the transformed field at the center of the data window is computed by premultiplying the equivalent source matrix by the row of the Green’ ...
Tópico(s): Computational Physics and Python Applications
1989 - Society of Exploration Geophysicists | Geophysics
Produção Nacional
Revisado por pares
Roldão Faleiro de Almeida, Inês Leão, João Bosco Lima Gomes, Ariovaldo Alberto da Silva, Antônio Lúcio Teixeira,
Persistent migraine aura without infarction is a rare but well documented condition. According to the International Headache Society (HIS) criteria, this disturbance is defined by the persistence of a migraine aura for more than one week without radiographic evidence of infarction.1 Here we describe the case of an 11-year-old girl suffering from migraine without aura since the age of four. She experienced two episodes of persistent negative visual aura with no evidence of infarction. To the best ...
Tópico(s): Trigeminal Neuralgia and Treatments
2009 - Elsevier BV | Clinics
M.T. Ponce de Leão, João Tomé Saraiva,
We describe an integrated methodology to compute long-term marginal prices in distribution networks. Long-term marginal prices are considered the most interesting and economically sound way of allocating network costs to users. Additionally, they inherently deal with the revenue-reconciliation problem, as they generally do not require other large supplementary tariff terms. The proposed methodology uses fuzzy sets to model uncertainties in load forecasts and considers several criteria to guide the ...
Tópico(s): Energy Load and Power Forecasting
2002 - Institute of Electrical and Electronics Engineers | IEEE Power Engineering Review
M.T. Ponce de Leão, João Tomé Saraiva,
In this paper, the authors describe an integrated methodology to compute long-term marginal prices in distribution networks. Long-term marginal prices are considered the most interesting and economically sound way of allocating network costs to users. Additionally, they inherently deal with the revenue reconciliation problem, as they generally do not require other large supplementary tariff terms. The proposed methodology uses fuzzy sets to model uncertainties in load forecasts and considers several ...
Tópico(s): Smart Grid Energy Management
2003 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Systems
Produção Nacional
Revisado por pares
Michele Michelin, Tony M. Silva, Vívian Machado Benassi, Simone C. Peixoto-Nogueira, Luiz Alberto Beraldo de Moraes, J.M. Leão, João Atílio Jorge, Héctor F. Terenzi, Maria de Lourdes Teixeira de Moraes Polizeli,
An α-amylase produced by Paecilomyces variotii was purified by DEAE-cellulose ion exchange chromatography, followed by Sephadex G-100 gel filtration and electroelution. The α-amylase showed a molecular mass of 75 kDa (SDS–PAGE) and pI value of 4.5. Temperature and pH optima were 60 °C and 4.0, respectively. The enzyme was stable for 1 h at 55 °C, showing a t50 of 53 min at 60 °C. Starch protected the enzyme against thermal inactivation. The α-amylase was more stable in alkaline pH. It was activated ...
Tópico(s): Studies on Chitinases and Chitosanases
2010 - Elsevier BV | Carbohydrate Research
Nuno S. Osório, Agostinho Carvalho, Agostinho J. Almeida, Sergio Padilla-López, Cecı́lia Leão, João Laranjinha, Paula Ludovico, David A. Pearce, Fernando Rodrigues,
The juvenile form of neuronal ceroid lipofuscinoses (JNCLs), or Batten disease, results from mutations in the CLN3 gene, and it is characterized by the accumulation of lipopigments in the lysosomes of several cell types and by extensive neuronal death. We report that the yeast model for JNCL (btn1-Δ) that lacks BTN1, the homologue to human CLN3, has increased resistance to menadione-generated oxidative stress. Expression of human CLN3 complemented the btn1-Δ phenotype, and equivalent Btn1p/Cln3 mutations ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2007 - American Society for Cell Biology | Molecular Biology of the Cell
Bruno Almeida, Sabrina Büttner, Steffen Ohlmeier, Alexandra Silva, Ana Mesquita, Belém Sampaio‐Marques, Nuno S. Osório, Alexander Kollau, Bernd Mayer, Cecı́lia Leão, João Laranjinha, Fernando Rodrigues, Frank Madeo, Paula Ludovico,
Nitric oxide (NO) is a small molecule with distinct roles in diverse physiological functions in biological systems, among them the control of the apoptotic signalling cascade. By combining proteomic, genetic and biochemical approaches we demonstrate that NO and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are crucial mediators of yeast apoptosis. Using indirect methodologies and a NO-selective electrode, we present results showing that H2O2-induced apoptotic cells synthesize NO that is associated ...
Tópico(s): Redox biology and oxidative stress
2007 - The Company of Biologists | Journal of Cell Science
Produção Nacional
Revisado por pares
Luiza Wilges Kist, Denis B. Rosemberg, Talita Carneiro Brandão Pereira, Mariana Barbieri de Azevedo, Stefânia Konrad Richetti, Janaína de Castro Leão, João Yúnes, Carla Denise Bonan, Maurı́cio Reis Bogo,
Microcystins (MCs) constitute a family of cyanobacterial toxins, with more than 80 variants. These toxins are able to induce hepatotoxicity in several organisms mainly through the inhibition of protein phosphatases PP1 and PP2A and oxidative stress generation. Since recent evidence shows that MCs can either accumulate in brain or alter behavior patterns of fish species, in this study we tested the in vitro and in vivo effects of MC-LR at different concentrations on acetylcholinesterase (AChE) activity ...
Tópico(s): Marine Toxins and Detection Methods
2011 - Elsevier BV | Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
Pedro Leão, João Carlos Sousa, Miguel Oliveira, R. Silva, Osborne F. X. Almeida, Nuno Sousa,
Abstract Elevated glucocorticoids, during pregnancy, alter emotionality and increase propensity to drug abuse later in life, albeit through substrates and mechanisms are largely unknown. In this study, we examined whether antenatal glucocorticoid exposure induces enduring structural changes in the nucleus accumbens (NAcc), an important relay point in the reward limbic circuitry. To this end, rat dams were exposed to the synthetic glucocorticoid dexamethasone (DEX) on days 18 and 19 of gestation, and ...
Tópico(s): Birth, Development, and Health
2006 - Wiley | Synapse
Produção Nacional
Revisado por pares
Priscilla Filomena Fonseca Amaral, Ana Paula R. de Almeida, Tathiana Peixoto, Maria Helena M. Rocha‐Leão, João A. P. Coutinho, Maria Alice Zarur Coelho,
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2006 - Springer Science+Business Media | World Journal of Microbiology and Biotechnology
Mamie Mizusaki Iyomasa, Élen Rizzi, Juliane Caroline Leão, João Paulo Mardegan Issa, Fernando José Días, Yamba Carla Lara Pereira, Maria José Vieira Fonseca, Fabiana T. M. C. Vicentini, Ii‐Sei Watanabe,
Tópico(s): Salivary Gland Disorders and Functions
2012 - Springer Science+Business Media | Lasers in Medical Science
Produção Nacional
Revisado por pares
Sofia C. Nunes, Raquel Sá‐Leão, João André Carriço, Cláudia Alves, R. Mato, A. Brito Avô, Joana Saldanha, Jonas S. Almeida, Ilda Santos‐Sanches, Hermı́nia de Lencastre,
Of the nasopharyngeal cultures recovered from 942 day care center (DCC) attendees in Lisbon, Portugal, 591 (62%) yielded Streptococcus pneumoniae during a surveillance performed in February and March of 1999. Forty percent of the isolates were resistant to one or more antimicrobial agents. In particular, 2% were penicillin resistant and 20% had intermediate penicillin resistance. Multidrug resistance to macrolides, lincosamides, and tetracycline was the most frequent antibiotype (17% of all isolates). ...
Tópico(s): Bacterial Infections and Vaccines
2005 - American Society for Microbiology | Journal of Clinical Microbiology
Vinícius Silva, Filomena Soares, Celina P. Leão, João Sena Esteves, Gianni Vercelli,
Individuals with Autism Spectrum Disorder (ASD) typically present difficulties in engaging and interacting with their peers. Thus, researchers have been developing different technological solutions as support tools for children with ASD. Social robots, one example of these technological solutions, are often unaware of their game partners, preventing the automatic adaptation of their behavior to the user. Information that can be used to enrich this interaction and, consequently, adapt the system behavior ...
Tópico(s): Down syndrome and intellectual disability research
2021 - Multidisciplinary Digital Publishing Institute | Sensors
Produção Nacional
Revisado por pares
Renato Ambrósio, Aydano Pamponet Machado, Edileuza Virginio Leão, João Marcelo G. Lyra, Marcella Q. Salomão, Louise G. Pellegrino Esporcatte, João Batista R. da Fonseca Filho, Erica Ferreira-Meneses, Nelson Sena, Jorge Selem Haddad, Alexandre Batista da Costa Neto, Gildasio Castelo de Almeida, Cynthia J. Roberts, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Jens Bühren, Thomas Kohnen, Guy M. Kezirian, Farhad Hafezi, Nikki L. Hafezi, Emilio A. Torres‐Netto, Nan‐Ji Lu, David Sung Yong Kang, Omid Kermani, Shizuka Koh, Prema Padmanabhan, Suphi Taneri, William Trattler, Luca Gualdi, José Salgado‐Borges, Fernando Faria-Correia, Elias Flockerzi, Berthold Seitz, Vishal Jhanji, Tommy C.Y. Chan, Pedro Manuel Baptista, Dan Z. Reinstein, Timothy J. Archer, Karolinne Maia Rocha, George O. Waring, Ronald R. Krueger, William J. Dupps, Ramin Khoramnia, Hassan Hashemi, Soheila Asgari, Hamed Momeni‐Moghaddam, Siamak Zarei‐Ghanavati, Rohit Shetty, Pooja Khamar, Michael W. Belin, Bernardo T. Lopes,
To optimize artificial intelligence (AI) algorithms to integrate Scheimpflug-based corneal tomography and biomechanics to enhance ectasia detection.Multicenter cross-sectional case-control retrospective study.A total of 3886 unoperated eyes from 3412 patients had Pentacam and Corvis ST (Oculus Optikgeräte GmbH) examinations. The database included 1 eye randomly selected from 1680 normal patients (N) and from 1181 "bilateral" keratoconus (KC) patients, along with 551 normal topography eyes from patients ...
Tópico(s): Glaucoma and retinal disorders
2022 - Elsevier BV | American Journal of Ophthalmology
Produção Nacional
Revisado por pares
Flávia Sousa Arantes, Vinícius Rosa Oliveira, Aime Karla Moraes Leão, João Pedro Ribeiro Afonso, Adriano L. Fonseca, Daniela Rosana Pedro Fonseca, Diego Antonio C. Pina Gomes Mello, Ivan Peres Costa, Luiz Vicente Franco Oliveira, Renata Kelly da Palma,
Frailty is a state of critical loss of physiological complexity resulting in greater vulnerability to stressors and has been characterized as a debility syndrome in the older adult. Changes in functional capacity and the cardiovascular system during aging are the most significant and relevant for this population, including the clinically healthy. In this sense, this review aims to investigate methods to monitor the performance of older adults, such as heart rate variability and verify how it can ...
Tópico(s): Body Composition Measurement Techniques
2022 - Frontiers Media | Frontiers in Medicine
Berta Carvalho, Mónica Pereira, C. Joana Marques, Davide Carvalho, Miguel Leão, João Paulo Oliveira, Alberto Barros, Filipa Carvalho,
Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency is a common autosomal recessive disorder caused by mutations in the steroid 21-hydroxylase gene ( CYP21A2 ). Complete DNA sequencing of CYP21A2 was performed in 5 patients, 3 non-classic and 2 classic forms of the disease, that were previously screened for the 10 most common mutations, in order to detect additional mutations that could justify the phenotype of the patients. 5 mutations were identified with the whole gene extended analysis. ...
Tópico(s): Hormonal and reproductive studies
2012 - Thieme Medical Publishers (Germany) | Experimental and Clinical Endocrinology & Diabetes
Produção Nacional
Revisado por pares
A. Bewketu Belete, J. P. Bravo, B. L. Canto Martins, I. C. Leão, João M. de Araújo, J. R. De Medeiros,
The presence of multifractality in a time series shows different correlations for different time scales as well as intermittent behaviour that cannot be captured by a single scaling exponent. The identification of a multifractal nature allows for a characterization of the dynamics and of the intermittency of the fluctuations in non-linear and complex systems. In this study, we search for a possible multifractal structure (multifractality signature) of the flux variability in the quasar 3C 273 time ...
Tópico(s): Earthquake Detection and Analysis
2018 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Produção Nacional
Revisado por pares
Máría de Fátima Viana Vasco Aragão, Mariana de Carvalho Leal Gouveia, Pedro Andrade, Ocelio Cartaxo Filho, Lucas Vasco Aragao, Tatiana Fonseca, Marcelo Andrade Valença, Maria Regina Vendas Carneiro Leao, Joao Pedro Vasco Aragao, Maria Lúcia Lima Soares, Maria Júlia Martins Oliveira Lima, Sílvio da Silva Caldas Neto, Marcelo Andrade Valença,
Patients with COVID-19 can require radiological examination, with chest CT being more frequent than neuro-imaging. The objective is to identify epidemiological, clinical and radiological factors considered as predictors of neurological involvement in patients with COVID-19 assessed by neuroimaging and to describe the neuroimaging findings. This retrospective study was performed with 232 consecutive confirmed COVID-19 patients, from two radiological units, which were divided into two groups: (1) those ...
Tópico(s): Infectious Encephalopathies and Encephalitis
2021 - Multidisciplinary Digital Publishing Institute | Viruses
The question of saturation of self-organized criticality in the ``game of Life'' is analyzed through finite-size scaling. We have carried out connection-machine simulations for lattices up to 1024\ifmmode\times\else\texttimes\fi{}1024. In that range we find no evidence of saturation. We do, however, find finite-size exponents that seem inconsistent with a single length-scale picture at criticality.
Tópico(s): Stochastic processes and statistical mechanics
1994 - American Physical Society | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
Produção Nacional
Revisado por pares
Fabrizio Grandi, Márcia Moleta Colodel, Lidianne N. Monteiro, João Leão, Noeme Sousa Rocha,
Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone marrow or hematological disorders. Mammary EMH is a rare condition either in human and veterinary medicine and can be associated with benign mixed mammary tumors, similarly to that described in this case. Hematopoietic stem cells were found in a benign ...
Tópico(s): TGF-β signaling in diseases
2010 - BioMed Central | BMC Veterinary Research
Produção Nacional
Revisado por pares
Eunice Maia de Andrade, Helba Palácio, Ivam Holanda de Souza, Raimundo Alípio de Oliveira Leão, Maria João Guerreiro,
Multivariate statistical techniques, cluster analysis (CA) and factor analysis/principal component analysis (FA/PCA), were applied to analyze the similarities or dissimilarities among the sampling sites to identify spatial and temporal variations in water quality and sources of contamination (natural and anthropogenic). The aquifer under study is supplied by the Trussu River, which has a general direction from west to east, within Iguatu County, Ceará, Brazil. Groundwater samples were collected in ...
Tópico(s): Groundwater and Watershed Analysis
2007 - Elsevier BV | Environmental Research
Cecília Alves-Araújo, Andreia Pacheco, M. J. Almeida, Isabel Spencer‐Martins, Cecı́lia Leão, Maria João Sousa,
The highly osmo- and cryotolerant yeast species Torulaspora delbrueckii is an important case study among the non-Saccharomyces yeast species. The strain T. delbrueckii PYCC 5321, isolated from traditional corn and rye bread dough in northern Portugal, is considered particularly interesting for the baking industry. This paper reports the sugar utilization patterns of this strain, using media with glucose, maltose and sucrose, alone or in mixtures. Kinetics of growth, biomass and ethanol yields, fermentation ...
Tópico(s): Biofuel production and bioconversion
2007 - Microbiology Society | Microbiology
Júlia Santos, Cecı́lia Leão, Maria João Sousa,
Ammonium ( NH 4 + ) leads to chronological life span (CLS) shortening in Saccharomyces cerevisiae BY4742 cells, particularly evident in cells starved for auxotrophy-complementing amino acids (leucine, lysine, and histidine) simultaneously. Here, we report that the effect of NH 4 + on aging yeast depends on the specific amino acid they are deprived of. Compared with no amino acid starvation, starvation for leucine alone or in combination with histidine resulted in the most pronounced NH 4 + -induced CLS shortening, ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2013 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Produção Nacional
Revisado por pares
Marilisa Carneiro Leão Gabardo, João César Zielak, Gabriela Tórtora, Jennifer Tsi Gerber, Michelle Nascimento Meger, Nelson Luís Barbosa Rebellato, Érika Calvano Küchler, Rafaela Scariot,
Dentofacial deformities have an impact on quality of life (QOL). Many factors can influence this perception, including genetic aspects. ANKK1 and DRD2 genes are associated with dopaminergic system and could modulate behavioral dysfunction.The impact of orthognathic surgery and associated factors on QOL of adults was evaluated.The abbreviated World Health Organization Quality of Life questionnaire (WHOQOL-BREF) was applied to patients from two surgery services one week before (T0) and six months after ...
Tópico(s): Dental Anxiety and Anesthesia Techniques
2019 - Elsevier BV | Journal of Cranio-Maxillofacial Surgery
Mário Oliveira, Pedro Leão, Ana João Rodrigues, José Miguel Pêgo, João Cerqueira, Nuno Sousa,
Brain regions implicated in sexual behavior begin to differentiate in the last trimester of gestation. Antenatal therapy with corticosteroids is often used in clinical practice during this period to accelerate lung maturation in preterm-risk pregnancies. Clinical and animal studies highlighted major behavioral impairments induced later in life by these treatments, especially when synthetic corticosteroids are used.To evaluate the implications of acute prenatal treatment with natural vs. synthetic ...
Tópico(s): Prenatal Substance Exposure Effects
2011 - Elsevier BV | The Journal of Sexual Medicine
Produção Nacional
Revisado por pares
Teresa Cristina Tarlé Pissarra, Aline Braga Marcussi, Gilberto da R. Leão, João Antônio Galbiatti, Maurício José Borges, Sérgio Campos,
The aim of this study was to define the photographic patterns that represent the use and occupation of the landcover of the "spring" of the Rico Stream subbasin, located at Monte Alto, state of São Paulo (SP), Brazil, for environmental adaptation regarding the Brazilian Forest Law. The mapping was performed using remote sensing techniques and visual interpretation of the World View image, followed by the digitalization of the net of drainage and vegetation (natural and agricultural) at the AutoCad ...
Tópico(s): Environmental and biological studies
2013 - Sociedade Brasileira de Engenharia Agrícola | Engenharia Agrícola
Júlia Santos, Cecı́lia Leão, Maria João Sousa,
The manipulation of nutrient-signaling pathways in yeast has uncovered the impact of environmental growth conditions in longevity. Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS). Other components of the culture media and factors such as the products of fermentation have also been implicated in the regulation of CLS. Acidification of the culture media mainly due to acetic acid and ...
Tópico(s): Fungal and yeast genetics research
2012 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Filippo Balestrieri, Sergei Izmalkov, João Leão,
Abstract In this paper, we solve the revenue maximization problem of a multi-product monopolist when the products are substitutes. We consider a Hotelling model with two horizontally differentiated goods located at the endpoints of the segment. Consumers are located uniformly on the segment; their valuations for each good are equal to the base consumption value minus distance costs. When the base consumption value is high, the seller maximizes her expected profit by offering a menu of base and opaque ...
Tópico(s): Digital Platforms and Economics
2020 - Oxford University Press | Journal of the European Economic Association