Produção Nacional
Revisado por pares
R. M. Endo, Manoel Joâo Batista Castello Girão, Marair Grácio Ferreira Sartori, Manuel de Jesus Simões, Edmund Chada Baracat, G. Rodrigues de Lima,
Tópico(s): Urinary Tract Infections Management
2000 - Springer Science+Business Media | International Urogynecology Journal
Produção Nacional
Revisado por pares
Elaine Travaglia Santos, Maria Dione Dutra Sampaio, Paulo Roberto Cecon, Manuel de Jesus Simões, Marair Grácio Ferreira Sartori, Manoel Joâo Batista Castello Girão,
Tópico(s): Estrogen and related hormone effects
2009 - Springer Science+Business Media | International Urogynecology Journal
Produção Nacional
Revisado por pares
Luciana Bueno Ferreira, Etel Rodrigues Pereira Gimba, João Vinagre, Manuel Sobrinho‐Simões, Paula Soares,
In thyroid cancer, calcification is mainly present in classical papillary thyroid carcinoma (PTC) and in medullary thyroid carcinoma (MTC), despite being described in benign lesions and in other subtypes of thyroid carcinomas. Thyroid calcifications are classified according to their diameter and location. At ultrasonography, microcalcifications appear as hyperechoic spots ≤ 1 mm in diameter and can be named as stromal calcification, bone formation, or psammoma bodies (PBs), whereas calcifications > 1 mm ...
Tópico(s): Vitamin D Research Studies
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Ana Raquel Soares, Patrícia M. Pereira, Violeta Ferreira, Marisa Reverendo, João Simões, Ana Rita Bezerra, Gabriela Moura, Manuel A. S. Santos,
Prenatal exposure to ethanol leads to a myriad of developmental disorders known as fetal alcohol spectrum disorder, often characterized by growth and mental retardation, central nervous system damage, and specific craniofacial dysmorphic features. The mechanisms of ethanol toxicity are not fully understood, but exposure during development affects the expression of several genes involved in cell cycle control, apoptosis, and transcriptional regulation. MicroRNAs (miRNAs) are implicated in some of ...
Tópico(s): Fish Ecology and Management Studies
2012 - Oxford University Press | Toxicological Sciences
Tiago Krug, Helena Manso, Liliana Gouveia, João Sobral, Joana M. Xavier, Isabel Soares de Albergaria, Gisela Gaspar, Manuel Correia, Miguel Viana‐Baptista, Rita Moiron Simões, Amélia Nogueira Pinto, Ricardo Taipa, Carla Ferreira, João Ramalho Fontes, Mário Rui Silva, João Paulo Gabriel, Ilda Matos, Gabriela Lopes, José M. Ferro, Astrid M. Vicente, Sofia A. Oliveira,
Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and metabolic phenotypes, but no studies have yet been performed in stroke patients. KALRN is involved, among others, in the inhibition of inducible ...
Tópico(s): Nuclear Receptors and Signaling
2010 - Springer Science+Business Media | Human Genetics
Produção Nacional
Revisado por pares
Marco Rocha, Marair Grácio Ferreira Sartori, Manuel de Jesus Simões, Viviane Herrmann, Edmund Chada Baracat, G. Rodrigues de Lima, Manoel Joâo Batista Castello Girão,
Tópico(s): Pregnancy-related medical research
2006 - Springer Science+Business Media | International Urogynecology Journal
Alexandra Rosa, Benedita V. Fonseca, Tiago Krug, Helena Manso, Liliana Gouveia, Isabel Soares de Albergaria, Gisela Gaspar, Manuel Correia, Miguel Viana‐Baptista, Rita Moiron Simões, Amélia Nogueira Pinto, Ricardo Taipa, Carla Ferreira, João Ramalho Fontes, Mário Rui Silva, João Paulo Gabriel, Ilda Matos, Gabriela Lopes, José M. Ferro, Astrid M. Vicente, Sofia A. Oliveira,
Abstract Background The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to assess the contribution of mtDNA polymorphisms and haplogroups to ischemic stroke ...
Tópico(s): Metabolism and Genetic Disorders
2008 - BioMed Central | BMC Medical Genetics
Produção Nacional
Revisado por pares
João Vinagre, Fátima Borges, Antà nio Costa, Maria InÃas Alvelos, Gláucia Maria Ferreira da Silva Mazeto, Manuel Sobrinho‐Simões, Paula Soares,
Resistance to thyroid hormone (RTH) represents a syndrome in which patients present elevated circulating thyroid hormones in the presence of non-suppressed TSH. We report a novel case where a patient with RTH presented a differentiated thyroid cancer. A19 year-old female had been referred due to thyroid disease that disclosed features characteristic of a RTH. During the follow up it was detected a follicular tumor that led to the recommendation for thyroid surgical ablation, where an incidental papillary ...
Tópico(s): Neuroendocrine Tumor Research Advances
2014 - Frontiers Media | Frontiers in Molecular Biosciences
Filipe Manuel dos Reis Simões da Silva, Peter Pêgo, Maria Cristina Henriques Vendrell, Maria João de Azevedo Batalha Ferreira dos San, Ângela Timóteo, Maria Cristina Martins da Costa, Isabel Cravo, Fernando Gomes,
Posterior reversible encephalopathy syndrome is an increasingly recognised clinico-radiological entity, associated with several medical conditions (such as systemic arterial hypertension) and characterised by seizures, altered mental status, headaches, and visual symptoms. Magnetic resonance imaging is a key component in this diagnosis, with hyperintense foci in T2-weighted images, corresponding to vasogenic oedema. The pathophysiology is not fully understood but probably involves loss of auto-regulation ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2011 - Taylor & Francis | Neuro-Ophthalmology
Produção Nacional
João Alberto Vilar Mamede, Manuel de Jesus Simões, Neil Ferreira Novo, Yára Juliano, Ricardo Martins Oliveira-Filho, L Kulay,
1. The antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. In the present study we examined the effects of such an association on rat pregnancy. 2. AZT (60 mg/kg b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once a day from the 1st to the 20th day of gestation. 3. Maternal body weight gain was severely affected by ACV; this effect was attenuated in rats treated with AZT+ ...
Tópico(s): HIV/AIDS drug development and treatment
1995 - Elsevier BV | General Pharmacology The Vascular System
Antonio C. Martinho, José João Mendes, Onofre Simões, Rhewter Nunes, Julia do Amaral Gomes, E. Dias Castro, Paula Pinto, Manuel Branco Ferreira, Celso Pereira, M.G. Castel-Branco, Lynn Pais,
Mutations that modify the amino acid sequence of C1-INH (except Val458Met) are associated with HAE. More than 200 different mutations scattering the entire C1-INH gene have been reported. The main objective of this study was to report the mutational findings in a HAE cohort of 138 Portuguese patients followed in specialized consultation all over the country. DNA was extracted from peripheral blood with QiaSymphony BioRobot (QIAGEN Portugal). The sequence reactions were performed by using a DNA sequencing ...
Tópico(s): Hemophilia Treatment and Research
2012 - Elsevier BV | Molecular Immunology
Produção Nacional
Revisado por pares
Marco Rocha, Marair Grácio Ferreira Sartori, Manuel de Jesus Simões, Viviane Herrmann, Edmund Chada Baracat, G. Rodrigues de Lima, Manoel Joâo Batista Castello Girão,
Tópico(s): Urinary Bladder and Prostate Research
2007 - Springer Science+Business Media | International Urogynecology Journal
Grant Mair, Rüdiger von Kummer, Zoë Morris, Anders von Heijne, Nick Bradey, Lesley Cala, André Peeters, Andrew Farrall, Alessandro Adami, Gillian Potter, Geoff Cohen, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Colin Baigent, David Chadwick, Pippa Tyrrell, Gordon Lowe, Martin Dennis, Geoff Cohen, Karen Innes, Heather Goodare, Richard I. Lindley, Graeme J. Hankey, Karl Matz, Michael Brainin, Gord Gubitz, Stephen Phillips, Stefano Ricci, Antonio Araúz, Eivind Berge, Karsten Bruins Slot, Anna Członkowska, Adam Kobayashi, Manuel Correia, Phillippe Lyrer, Stefan T. Engelter, Veronica Murray, Andreas Terént, Bo Norrving, Per Wester, G.S. Venables, Joanna M. Wardlaw, Andrew Farrall, Zoë Morris, Rüdiger von Kummer, Lesley Cala, Anders von Heijne, Alessandro Adami, André Peeters, Gillian Potter, Nick Bradey, Joanna M. Wardlaw, Rüdiger von Kummer, Andrew Farrall, Robin Sellar, Alessandro Adami, Phil White, Andrew M. Demchuk, Matthew Adams, Grant Mair, Bernard Yan, G.S. Venables, C Blank, Helen Bowler, Cara Doyle, Keith Endean, K. Harkness, Edward F. Parker, Marc Randall, Christine Roffe, Naveed Ahmad, Anand Arora, Susan V. Brammer, J Chembala, B. Davies, Sarah J. Ellis, Richard H. Epstein, K. Finney, Chris Jackson, Changez Jadun, Ruth Kinston, Holly Maguire, I Memon, Indira Natarajan, Michael Poulson, R. Sanyal, Sheila Sills, ANNA E. M. VREEBURG, Elizabeth Ward, Peter Sandercock, Rustam Al‐Shahi Salman, Richard Davenport, Martin Dennis, Peter J. Hand, Simon P. Hart, Ingrid Kane, Sarah Keir, Mary Joan MacLeod, L McKinlay, Hazel Milligan, E SANDEMAN, Jennifer Stone, Cathie Sudlow, Peter R. Taylor, Joanna M. Wardlaw, C Warlow, William Whiteley, A. Olufemi Williams, M. Brown, B.S. Athwal, Vanessa Bassan, Neelima Bhupathiraju, John V. Bowler, Charles Davie, David Doig, Renuka Erande, Stephen Gilbert, Lionel Ginsberg, Nan Greenwood, Simone M. Gregoire, Nicola Harding, Nicholas Losseff, Robert Luder, Nathalie Passeron, Richard Perry, Philip Rayson, Robert Simister, Simon Stone, David J. Werring, James Barrett, H Aitken, Sarah Cherian, Ryan L. Davis, Susan Downham, L Godd, V. L. Gott, David José, Victoria Little, David Lowe, L Luxford, Matthew T. McGrory, Paula Owings, N Price, John Richards, Graeme Sangster, Julian Sherlock, Susan Vargese, Ian Wakefield, Pauline Weir, Paul Guyler, T Attygale, Susan M. Chandler, Lucy Coward, S Feasey, C Khuoge, Thayalini Loganathan, Sascha E. Martin, Anne Sibley O'Brien, D Sinha, Vanessa R. Thompson, Sharon Tysoe, Richard Walsh, Kerstin Metcalf, Jeffrey I. Cochius, Ryan P. Fulcher, Nisal Gange, Catherine Green, Jacqui Jagger, M Lee, Phyo Kyaw Myint, John F. Potter, Garth Ravenhill, Stephanie Shields, Naval Shinh, Tom Staunton, Eleanor Thomas, Wendy A. Woodward, P. H. L. WORTH, N. Wyatt, W Sunman, Philip M. Bath, Peter H. Berman, Judith Clarke, Catherine Gaynor, Fiona Hammonds, Rowan Harwood, Kate M. Mitchell, Soumyabrata Munshi, Sarah Pacey, Ashit Shetty, Nikola Sprigg, H Stear, G. Mani Subramanian, Andrew K. Wills, Anthony Rudd, Heinrich J. Audebert, Ajay Bhalla, Jonathan Birns, Rasheda A. Chowdhury, Gillian Cluckie, Ian G. Davies, Charlotte Gibbs, Patrick Holmes, Nicola J. Mitchell, Francesca Schiavone, Eleanor White, Meredith T. Yeung, A. Mehrzad, Vidyagauri P. Baliga, Eli M. Brown, Lewis Burnside, Bernard Esisi, Jennifer L. Kent, Orr P, David Stead, Emma Wayman, R Durairaj, C Cullen, Rohit Kumar, H Martı́n, Dermot T. McDowell, Alka Sharma, Victoria Sutton, Robert M. White, Thomas A. Hughes, Khalid Ali, J. Anderson, Katherine Baker, K Bethune, K Bethune, M Booth, M. Cossburn, Sophie Halpin, M D Hourihan, E. Neil G. Marsh, K. J. Peall, Rebecca Powell, Hamsaraj Shetty, M. Wardle, Michelle A. Williams, K Muhiddin, J. Beavan, M Clarke, R Donneley, Simon Elliott, Peter Fox, Peter H. Gorman, Margaret Harper, M Mangoyana, I Memon, Lisa Mills, L Wright, Liz Warburton, Jean‐Claude Baron, Peter Barry, Diana J. Day, Teresa Harold, Pilar Matía‐Martín, Jennifer Mitchell, Eoin O’Brien, J Rycarte, M Turnham, Geoffrey Cloud, L Y Lois Choy, Ben Clarke, C. J. Griffin, Omid Halse, Ifan Jones, Fiona Kennedy, Uzma Khan, Russell E. Lewis, Alison Loosemore, Caroline Lovelock, Markus Holtmannspötter, B. Moynihan, J. N. O'Reilly, Paul Olowoyo, Anthony Pereira, Martin Punter, Preston B. Rich, Debbie Rolfe, Francesca Schiavone, Martin James, James Bell, A. Bowring, Lucy Boxall, Julie Cageao, H. Eastwood, Salim Elyas, Fiona Hall, S. Harries, Anthony Hemsley,
Objective: To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). Methods: All prerandomization and follow-up (24–48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked raters. We assessed whether HAS grew, persisted, shrank, or disappeared at follow-up, the association with 6-month functional outcome, and effect of alteplase. ...
Lippincott Williams & Wilkins
Rui C. Martins, Ângelo Manuel Simões de Almeida Sacras, Sanja Jovanović, Patrícia Alves, Paula Ferreira, João Gomes,
Photocatalytic oxidation is promising technology for removal of recalcitrant pollutants from water. Solar energy can be an interesting radiation source since the operating costs can be lower. However, the use of powder photocatalyst is a major drawback of the technology since suitable separation technologies are required and catalysts recovery is difficult. This work aims to test the suitability of using polymeric supports to immobilize TiO 2 in the reactor and apply it for parabens removal from ...
Tópico(s): Membrane Separation Technologies
2022 - Elsevier BV | Energy Reports
Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batısta, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi‐Ruby, Bruno Cavadas, Luı́sa Pereira, Manuel Sobrinho‐Simões, Paula Soares,
Thyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS expression was addressed by qPCR and immunohistochemistry. In order to validate our data, ...
Tópico(s): Thyroid and Parathyroid Surgery
2018 - Bioscientifica | Endocrine Connections
João Vinagre, Joana Nabais, Jorge Pinheiro, Rui Batısta, Rui Caetano Oliveira, A. Pedro Gonçalves, Ana Pestana, M. Reis, Bárbara Mesquita, Vasco Pinto, Joana Lyra, Maria Augusta Cipriano, Miguel Godinho Ferreira, José Manuel Lopes, Manuel Sobrinho‐Simões, Paula Soares,
One of the hallmarks of cancer is its unlimited replicative potential that needs a compensatory mechanism for the consequential telomere erosion. Telomerase promoter (TERTp) mutations were recently reported as a novel mechanism for telomerase re-activation/expression in order to maintain telomere length. Pancreatic endocrine tumors (PETs) were so far recognized to rely mainly on the alternative lengthening of telomeres (ALT) mechanism. It was our objective to study if TERTp mutations were present in ...
Tópico(s): Mechanisms of cancer metastasis
2016 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Eliana Viana Monteiro Zucchi, Zsuzsanna Ilona Katalin de Jármy Di Bella, Rodrigo Aquino Castro, Cláudia Cristina Takano, Manuel de Jesus Simões, Manoel Joâo Batista Castello Girão, Marair Grácio Ferreira Sartori,
Abstract Objective To evaluate the expression of nerve growth factor (NGF) in the urethra of adult female rats in different hormonal status using immunohistochemical assay. Methods Forty‐eight rats (Rattus norvegicus albinus, Rodentia, Mammalia) from the CEDEME‐UNIFESP laboratory animal facility were used in the study. Rats were divided into four groups: group A, 12 non‐neutered rats; group B, 12 oophorectomized rats; group C, 12 castrated rats treated with 17β‐estradiol for 30 days; and group D, ...
Tópico(s): Stress Responses and Cortisol
2012 - Wiley | Neurourology and Urodynamics
Mafalda Simões Cunha, Rita Amaral, Ana Margarida Pereira, Rute Almeida, Magna Alves‐Correia, Cláudia Chaves Loureiro, Cristina Lopes, Joana Carvalho, Carmelita Ribeiro, Carmen Vidal, Darío Antolín‐Amérigo, Diana C. G. A. Pinto, Manuel Ferreira‐Magalhães, Maria João Vasconcelos, Carlos Lozoya, Natacha Santos, Francisca Cardia, Luís Taborda‐Barata, Rosário Ferreira, Pedro Morais Silva, Tania Monteiro Ferreira, Raquel Câmara, Eurico Silva, Diana Bordalo, Cristina Guimarães, Maria José Cálix, Sofia Da Silva, Maria Luís Marques, Ana Morête, Carlos Nunes, Claúdia Vieira, Rosália Páscoa, Adelaide Alves, José Varanda Marques, Bruno Reis, Luís Monteiro, Rosário Monteiro, Margarida Cepa, Bruno Valentim, Daniela Sousa Coelho, Sara Fernandes, Patrícia Meireles, Margarida Abreu Aguiar, Ana Rita Mourão, João Fonseca, Cristina Jácome,
Objectives Anxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with these symptoms. Methods This is a secondary analysis of the INSPIRERS studies. A total ...
Tópico(s): Eosinophilic Esophagitis
2023 - BMJ | BMJ Open
Catarina Tavares, Maria João Coelho, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batısta, Catarina Salgado, Catarina Eloy, Luciana Bueno Ferreira, Elisabete Rios, Manuel Sobrinho‐Simões, Paula Soares,
Activation of the mTOR pathway has been observed in thyroid cancer, but the biologic consequences regarding tumor behavior and patient prognosis remain poorly explored.We aimed to evaluate the associations of the mTOR pathway with clinicopathologic and molecular features and prognosis through the immunocharacterization of pmTOR and pS6 expression (as readouts of the pathway) in a series of 191 papillary thyroid carcinomas.pmTOR expression was associated with distant metastases (P = .05) and persistence ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2016 - Elsevier BV | Surgery
Produção Nacional
Revisado por pares
Maria Dione Dutra Sampaio, Zsuzsanna Ilona Katalin de Jármy Di Bella, Ismael Dale Cotrim Guerreiro da Silva, Elaine Travaglia Santos, Naiara Correa Nogueira-de-Souza, Eliana Viana Monteiro Zucchi, Manuel de Jesus Simões, Manoel Joâo Batista Castello Girão, Marair Grácio Ferreira Sartori,
Objective The purpose of this study was to investigate Vascular Endothelial Growth Factor Expression (VEGF) gene regulation by isoflavone in urinary tract tissues of castrated adult rats. Design Forty-five adult rats, 90 days old, weighting 200 g were used, receiving a soy-free ration. The animals were castrated for drug administration for 30 days (125 μg genisteine/g body weight/day) and sacrificed, divided into three groups: Group I—control; Group II—started isoflavone administration on the 5th ...
Tópico(s): Phytoestrogen effects and research
2009 - Elsevier BV | Maturitas
Paula Boaventura, Cecília Durães, Adélia Mendes, Natália R. Costa, Inês Chora, Sara Ferreira, Emanuel Araújo, Pedro Lopes, Gilberto Pires da Rosa, Pedro Marques, Sofia Tavares, Vanessa Chaves, Paulo Bettencourt, Inés Oliveira, Francisco Costa, Isabel Ramos, Maria José Teles, João Tiago Guimarães, Manuel Sobrinho‐Simões, Paula Soares,
Nontargeted late effects of radiation include an increased risk of cardiovascular disease, although this is still debatable in the context of low-dose radiation. Tinea capitis patients treated in childhood with X rays to induce scalp epilation received a low dose of radiation to their carotids. To better clarify this issue, we evaluated carotid atherosclerosis in a cohort of such patients treated in 1950–1963 in Portugal. A group of 454 individuals randomly chosen from previously observed Portuguese ...
Tópico(s): Effects of Radiation Exposure
2018 - Radiation Research Society | Radiation Research
Produção Nacional
Revisado por pares
Luciana Campanatti Crema, Zsuzsanna Ilona Katalin de Jármy Di Bella, Cláudia Cristina Takano, Rodrigo Aquino Castro, Manuel de Jesus Simões, Marair Grácio Ferreira Sartori, Manoel Joâo Batista Castello Girão,
Objective: The purpose of this study was to evaluate the postoperative morphologic aspects of neovaginoplasty by the McIndoe technique with the use of an oxidized cellulose membrane (Interceed®) – an absorbable adhesion barrier – to correct congenital vaginal defects. Design: This study was designed as a prospective study. Patients and Methods: The sample consisted of 10 patients treated at the Department of Urogynecology, Federal University of São Paulo, 7 patients with Mayer–Rokitansky–Küster–Hauser ...
Tópico(s): Sexual Differentiation and Disorders
2013 - Mary Ann Liebert, Inc. | Journal of Gynecologic Surgery
Produção Nacional
Revisado por pares
Gisela Rosa Franco, Emerson de Oliveira, Edmund Chada Baracat, Manuel de Jesus Simões, Marair Gracio Ferreira Sartoria, Manoel Joâo Batista Castello Girão, Rodrigo Aquino Castro,
Objective: We sought to analyze the effects of electrical stimulation (ES) of the pelvic floor on the bladder of rats.Methods: Forty rats were studied and divided into the following groups: GI (control group) -did not receive ES, GII (placebo) -did not receive ES but had an electrode inserted into the vagina; GIII -underwent six sessions of ES of the pelvic floor and GIV -rats that underwent 12 sessions of ES.Subsequently, the bladder was removed and the epithelium, muscle and blood vessels were analyzed. ...
Tópico(s): Pelvic floor disorders treatments
2011 - Brazilian Medical Association | Revista da Associação Médica Brasileira
Paula Boaventura, Cecília Durães, Adélia Mendes, Natália R. Costa, Inês Chora, Sara Ferreira, Emanuel Araújo, Pedro Lopes, Gilberto Pires da Rosa, Pedro Marques, Paulo Bettencourt, Inés Oliveira, Francisco Costa, Isabel Ramos, Maria José Teles, João Tiago Guimarães, Manuel Sobrinho‐Simões, Paula Soares,
Head and neck cancers, and cardiovascular disease have been described as late effects of low dose radiation (LDR) exposure, namely in tinea capitis cohorts. In addition to radiation dose, gender and younger age at exposure, the genetic background might be involved in the susceptibility to LDR late effects. The -174 G>C (rs1800795) SNP in IL6 has been associated with cancer and cardiovascular disease, nevertheless this association is still controversial. We assessed the association of the IL6-174 G> ...
Tópico(s): Lymphadenopathy Diagnosis and Analysis
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Tiago Bordeira Gaspar, Sofia Macedo, Ana Sá, Mariana Alves Soares, Daniela Ferreira Rodrigues, Mafalda Sousa, Nuno Mendes, Rui Sousa Martins, Luís Cardoso, Inês Borges, Şule Canberk, Fátima Gärtner, Leandro Miranda‐Alves, Manuel Sobrinho‐Simões, José Manuel Lopes, Paula Soares, João Vinagre,
ATRX is a chromatin remodeller that maintains telomere homeostasis. Loss of ATRX is described in approximately 10% of pancreatic neuroendocrine tumours (PanNETs) and associated with poorer prognostic features. Here, we present a genetically engineered mouse model (GEMM) addressing the role of Atrx loss (AtrxKO) in pancreatic β cells, evaluating a large cohort of ageing mice (for up to 24 months (mo.)). Atrx loss did not cause PanNET formation but rather resulted in worsening of ageing-related pancreatic ...
Tópico(s): Neuroblastoma Research and Treatments
2022 - Multidisciplinary Digital Publishing Institute | Cancers
João P. Ferreira, I. Simões, A. Paulo Coimbra, Manuel Crisóstomo,
With the increasing use of robots, industrial environments have changed. Industrial robots can perform heavy and repetitive tasks at high speed and precision. They are usually programmed to perform one or more specific tasks. Errors, alerts messages, restarts, indefinite stops with the need for someone to reset to the initial settings are some of the problems encountered when using robots. Because man and robot coexist in the same space, it is relevant to improve how they do relate, how they do ...
Tópico(s): Advanced Manufacturing and Logistics Optimization
2022 - Springer Science+Business Media | Communications in computer and information science
Elisabete Rodrigues, Ana Saavedra, João Pedro de Magalhães, Marta Pinto, P. Andrea-Ferreira, Manuel Sobrinho‐Simões, Paula Soares,
Tópico(s): Head and Neck Anomalies
2025 - Bioscientifica | Endocrine Abstracts
Liliana Simões‐Silva, Susana Ferreira, Maria João Sousa, Carla Santos-Araújo, Manuel Pestana, Isabel Soares‐Silva, Benedita Sampaio‐Maia,
Tópico(s): Diphtheria, Corynebacterium, and Tetanus
2015 - Oxford University Press | Nephrology Dialysis Transplantation
Produção Nacional
Revisado por pares
Gisela Rosa Franco, Emerson de Oliveira, Edmund Chada Baracat, Manuel de Jesus Simões, Marair Gracio Ferreira Sartoria, Manoel Joâo Batista Castello Girão, Rodrigo Aquino Castro,
We sought to analyze the effects of electrical stimulation (ES) of the pelvic floor on the bladder of rats. Forty rats were studied and divided into the following groups: GI (control group) - did not receive ES, GII (placebo) - did not receive ES but had an electrode inserted into the vagina; GIII - underwent six sessions of ES of the pelvic floor and GIV - rats that underwent 12 sessions of ES. Subsequently, the bladder was removed and the epithelium, muscle and blood vessels were analyzed. The muscle wall ...
Tópico(s): Urological Disorders and Treatments
2011 - Brazilian Medical Association | Revista da Associação Médica Brasileira
Produção Nacional
Gisela Rosa Franco, Emerson de Oliveira, Edmund Chada Baracat, Manuel de Jesus Simões, Marair Gracio Ferreira Sartoria, Manoel Joâo Batista Castello Girão, Rodrigo Aquino Castro,
We sought to analyze the effects of electrical stimulation (ES) of the pelvic floor on the bladder of rats. Forty rats were studied and divided into the following groups: GI (control group) - did not receive ES, GII (placebo) - did not receive ES but had an electrode inserted into the vagina; GIII - underwent six sessions of ES of the pelvic floor and GIV - rats that underwent 12 sessions of ES. Subsequently, the bladder was removed and the epithelium, muscle and blood vessels were analyzed. The muscle wall ...
Tópico(s): Urological Disorders and Treatments
2011 - Elsevier BV | Revista da Associação Médica Brasileira (English Edition)