From Christopher Walker and Brian Cashinella, By Marcel Berlins Legal Correspondent, By Michael Hatfield Political Staff, From Dan van der Vat, From Julian Mounter Motoring Correspondent, By Our Communications Reporter, From Christopher Walker, By David Wood Political Editor, By Our Labour Staff, By John Roper Medical Reporter, By Our Political Staff, By a Staff Reporter, By Ian Murray Labour Staff, By Geraldine Norman Sale Room Correspondent, By Our Defence Correspondent, From Fred Emery, From Our Correspondent, From Pearce Wright Science Correspondent, From Michael Knipe, From Peter Hazelhurst, From David Housego, From David Bonavia, From Denzil Peiris, From Richard Wigg, From Derek Wilson, From Mario Modiano, Stephen Walsh, Robert Anderson, Jeffery Daniels, Leonard Buckley, By Martin Gilbert, Cameron Hazlehurst, By S. G. Checkland, J. W. Burrow, Gerald Ely, From Michael Leapman, By Rex Bellamy Tennis Correspondent, From Sydney Friskin, By Julian Mounter Motoring Correspondent, From Peter West Rugby Correspondent, By Geoffrey Green Football Correspondent, Peter Hazelhurst, Oliver Woods, PHS, David Wood, EDWARD M. KENNEDY, , C. R. RITCHESON, , HARRY J. N. ANDRUSCHAK, , D. R. BATES, , KEYES., DONALD HALL, , MARJORY ALLEN OF HURTWOOD, , PAULINE BROOKES, , R. TURVEY, , M. EVERETT, , T. W. HUTCHISON, , JACK LONGLAND., JOYCE COPE, KATHRYN JONES, , P. SIEBER, , MICHAEL COLSTON, , PATRICIA HEREN, , MICHAEL HASTINGS, , IVAN MORRIS, , GEOFFREY AGNEW, Chairman, , JAMES REEVES., Penny Radford, Margaret Allen, Peter B. Fallows, From Our Diplomatic Correspondent, By Iverach McDonald, Sir George Seel writes:, By Richard Spiegelberg, From Dennis Topping, From Alan McGregor, From Frank Vogl, By Patricia Tisdall, By R. W. Shakespeare Northern Industrial Correspondent, By Arthur Reed Air Correspondent, By Giles Smith, By Michael Baily Shipping Correspondent, by Richard Spiegelberg, Frank Vogl, BY THE FINANCIAL EDITOR, By Ronald Kershaw Northern Industrial Correspondent, By Kenneth Owen, Ronald Kershaw, L. J. BROWNING, , PETER FELLGETT, , NEWALL., NEIL RECORD, , PHILIP D. DEFRIES, , D. C. BAMFORD, President, , JOÂO AUGUSTO de MEDICIS, , S. B. GRANT., M. E. MacGLASHAN, , G. L. BUTCHER, , Anthony Thomas, John Armytage, Sally White, by H. J. Maidenberg, by Marcus Vinicius Pratini de Moráes, by Andrew Goodrick-Clarke, by Margaret Allen, by Alfredo Moutinho dos Reis, by Sir Geoffrey Wallinger, by Kenneth King, by Shona Crawford Poole, S. C. P., H. J. M.,
News: Kremlin envoy meets leaders of Bangla Desh, Out of the Everywhere, The Pope sends sympathy for Glasgow victims, Three soldiers shot in day of riots ...
1971 - Gale Group | TDA
Sérgio Pereira, Filipe Magalhães, Álvaro Cunha, Carlos Moutinho, João Pacheco,
Tópico(s): Seismic Performance and Analysis
2021 - Springer Science+Business Media | Journal of Civil Structural Health Monitoring
T. N. S. Almeida, Filipe Moutinho, João P. Matos-Carvalho,
Quality control is an area of utmost importance for fabric production companies. By not detecting the defects present in the fabrics, companies are at risk of losing money and reputation with a damaged product. In a traditional system, an inspection accuracy of 60-75% is observed. In order to reduce these costs, a fast and automatic defect detection system, which can be complemented with the operator decision, is proposed in this paper. To perform the task of defect detection, a custom Convolutional ...
Tópico(s): Image Processing Techniques and Applications
2021 - Institute of Electrical and Electronics Engineers | IEEE Access
Daniel Carvalho, Carlos Sequeira, Ana Querido, Catarina Tomás, Tânia Morgado, Olga Valentim, Lídia Moutinho, João Gomes, Carlos Laranjeira,
Background The positive component of Mental Health Literacy (PMeHL) refers to a person’s awareness of how to achieve and maintain good mental health. Although explored recently, the term still lacks a clear definition among healthcare practitioners. Aim To identify the attributes and characteristics of PMeHL, as well as its theoretical and practical applications. Methods Literature search (using the Medline and CINAHL databases) and review, covering the last 21 years, followed by concept analysis ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2022 - Frontiers Media | Frontiers in Psychology
Maria João Nunes, Miguel Moutinho, Maria João Gama, Cecília M. P. Rodrigues, Elsa Rodrigues,
Cholesterol is an essential component of the central nervous system and increasing evidence suggests an association between brain cholesterol metabolism dysfunction and the onset of neurodegenerative disorders. Interestingly, histone deacetylase inhibitors (HDACi) such as trichostatin A (TSA) are emerging as promising therapeutic approaches in neurodegenerative diseases, but their effect on brain cholesterol metabolism is poorly understood. We have previously demonstrated that HDACi up-regulate CYP46A1 ...
Tópico(s): Nuclear Receptors and Signaling
2013 - Public Library of Science | PLoS ONE
Inês Milagre, Maria João Nunes, Margarida Castro‐Caldas, Miguel Moutinho, Maria João Gama, Elsa Rodrigues,
CYP46A1 is a neuron-specific cytochrome P450 that plays a pivotal role in maintaining cholesterol homeostasis in the CNS. However, the molecular mechanisms underlying human CYP46A1 expression are still poorly understood, partly because of the lack of a cellular model that expresses high levels of CYP46A1. Our previous studies demonstrated that specificity protein (Sp) transcription factors control CYP46A1 expression, and are probably responsible for cell-type specificity. Herein, we have differentiated ...
Tópico(s): Receptor Mechanisms and Signaling
2011 - Wiley | Journal of Neurochemistry
Produção Nacional
Revisado por pares
José Meira, Gonçalo Matos, André Perdigão, José Cação, Carlos Resende, Waldir Moreira, Mário Antunes, José Quevedo, Ruben Moutinho, João Oliveira, Pedro Rendeiro, Pedro Oliveira, Antônio Oliveira-Jr, José Santos, Rui L. Aguiar,
The next generation of mobile broadband communication, 5G, is seen as a driver for the industrial Internet of things (IIoT). The expected 5G-increased performance spanning across different indicators, flexibility to tailor the network to the needs of specific use cases, and the inherent security that offers guarantees both in terms of performance and data isolation have triggered the emergence of the concept of public network integrated non-public network (PNI-NPN) 5G networks. These networks might ...
Tópico(s): Network Time Synchronization Technologies
2023 - Multidisciplinary Digital Publishing Institute | Sensors
Filipe Vilas‐Boas, Tiago Ribeiro, João Afonso, Hélder Cardoso, Susana Lopes, Pedro Moutinho-Ribeiro, João Ferreira, Miguel Mascarenhas, Guilherme Macedo,
Endoscopic ultrasound (EUS) morphology can aid in the discrimination between mucinous and non-mucinous pancreatic cystic lesions (PCLs) but has several limitations that can be overcome by artificial intelligence. We developed a convolutional neural network (CNN) algorithm for the automatic diagnosis of mucinous PCLs. Images retrieved from videos of EUS examinations for PCL characterization were used for the development, training, and validation of a CNN for mucinous cyst diagnosis. The performance ...
Tópico(s): Colorectal Cancer Screening and Detection
2022 - Multidisciplinary Digital Publishing Institute | Diagnostics
Pedro Simões, Beatriz Moutinho Afonso, João Fernandes, José P. B. Mota,
The performance of a Kenics static mixer as a heat-transfer device for supercritical carbon dioxide (CO2) flow is studied and compared with conventional tube-in-tube heat exchangers. Measurements were carried out at pressures ranging from 8 to 21 MPa, temperatures from 283 to 323 K, and mass flowrates from 2 to 15 kg/h. The corresponding Reynolds and Prandtl numbers, at bulk conditions, ranged between 103 and 2 × 104 and between 2 and 7, respectively. The temperature increase experienced by the supercritical ...
Tópico(s): Subcritical and Supercritical Water Processes
2007 - Elsevier BV | The Journal of Supercritical Fluids
Eunice Bacelar, Dario L. Santos, José Moutinho‐Pereira, João I. Lopes, Berta Gonçalves, Timóteo C. Ferreira, Carlos M. Correia,
Tópico(s): Horticultural and Viticultural Research
2007 - Springer Science+Business Media | Plant and Soil
Ana Patrícia Lopes, J. P. Dubey, Osvaldo Moutinho, Maria João Gargaté, Anabela Vilares, M.A.M. Rodrigues, Luı́s Cardoso,
SUMMARY Seroprevalence of Toxoplasma gondii infection and associated risk factors were investigated in 401 women of childbearing age from the North of Portugal. Of the 98 (24·4%) seropositive women, 92 (93·9%) only had immunoglobulin (Ig)G, two (2·0%) only had IgM, and four (4·1%) others had both IgG and IgM. Risk factors for T. gondii infection in women were: engaging in soil-related activities without gloves [odds ratio (OR) 8·4], consumption of unwashed raw vegetables or fruit (OR 7·6), and consumption ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2011 - Cambridge University Press | Epidemiology and Infection
Hélder Fraga, Aureliano C. Malheiro, José Moutinho‐Pereira, João A. Santos,
Abstract The importance of viticulture and of the winemaking socioeconomic sector in Europe is largely acknowledged. The most famous winemaking regions in Europe commonly present very specific environmental characteristics, where climate often plays a central role. Furthermore, given the strong influence of the atmospheric factors on this crop, climate change can significantly affect yield and wine quality under future conditions. Trends recorded in the recent past on many viticultural regions in ...
Tópico(s): Wine Industry and Tourism
2012 - Wiley | Food and Energy Security
Miguel Moutinho, Maria João Nunes, Anita Quintal Gomes, Maria João Gama, Ángel Cedazo‐Mínguez, Cecília M. P. Rodrigues, Ingemar Björkhem, Elsa Rodrigues,
The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgenic mice overexpressing CYP46A1 show an improved cognitive function. These results raised the question of whether CYP46A1 expression can modulate the activity of proteins that are crucial ...
Tópico(s): Hormonal Regulation and Hypertension
2014 - Springer Science+Business Media | Molecular Neurobiology
Hélder Fraga, Aureliano C. Malheiro, José Moutinho‐Pereira, João A. Santos,
Tópico(s): Fermentation and Sensory Analysis
2013 - Springer Science+Business Media | International Journal of Biometeorology
Hélder Fraga, Aureliano C. Malheiro, José Moutinho‐Pereira, João A. Santos,
Establishing the role of climate on wine production is one major goal of the winemaking sector. Portuguese viticulture plays a key role in national exports of agro-food products. The Minho Wine Region, in particular, produces a unique wine type 'Vinho Verde' that has been taking its stand as a prominent international brand. The present study aims at improving the understanding of climate-yield relationships in this region. A long wine production series (1945–2010) is used and some transformations ...
Tópico(s): Fermentation and Sensory Analysis
2013 - Elsevier BV | Agricultural and Forest Meteorology
João Moutinho, Rui Esteves Araújo, Diamantino Freitas,
This paper presents an innovative evaluation and comparison of several methods and techniques necessary to implement an indoor localization system based on audible sound. Experiments were conducted in a room with conditions very close to possible practical application demonstrating that time delay estimation using generalized cross-correlation phase transform provides the best estimate to the distance to fixed anchors, and highlight the benefits of a new localization method entitled circle shrinking ...
Tópico(s): Music and Audio Processing
2015 - Elsevier BV | Pervasive and Mobile Computing
Miguel Moutinho, Maria João Nunes, Elsa Rodrigues,
Tópico(s): Peroxisome Proliferator-Activated Receptors
2016 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Miguel Moutinho, Maria João Nunes, Jorge C. Correia, Maria João Gama, Margarida Castro‐Caldas, Ángel Cedazo‐Mínguez, Cecília M. P. Rodrigues, Ingemar Björkhem, Jorge L. Ruas, Elsa Rodrigues,
Abstract Cholesterol 24-hydroxylase (CYP46A1) is responsible for brain cholesterol elimination and therefore plays a crucial role in the control of brain cholesterol homeostasis. Altered CYP46A1 expression has been associated with several neurodegenerative diseases and changes in cognition. Since CYP46A1 activates small guanosine triphosphate-binding proteins (sGTPases), we hypothesized that CYP46A1 might be affecting neuronal development and function by activating tropomyosin-related kinase (Trk) ...
Tópico(s): Receptor Mechanisms and Signaling
2016 - Nature Portfolio | Scientific Reports
Hélder Fraga, Iñaki García de Cortázar Atauri, Aureliano C. Malheiro, José Moutinho‐Pereira, João A. Santos,
<p class="Abstract" style="text-align: justify;"><strong>Aim:</strong> The winemaking sector in Portugal is of major socio-economic relevance, significantly contributing to the national exports and sustaining many wine-related activities, including oenotourism. Portuguese viticultural regions present a wide range of edaphoclimatic conditions with remarkable regional specificities, thus contributing to the individuality of their wines. Owing to the strong influence of climate and ...
Tópico(s): Fermentation and Sensory Analysis
2017 - ADERA | OENO One
Miguel Moutinho, Maria João Nunes, Elsa Rodrigues,
Cholesterol homeostasis greatly impacts neuronal function due to the essential role of this sterol in the brain. The mevalonate (MVA) pathway leads to the synthesis of cholesterol, but also supplies cells with many other intermediary molecules crucial for neuronal function. Compelling evidence point to a model in which neurons shutdown cholesterol synthesis, and rely on a shuttle derived from astrocytes to meet their cholesterol needs. Nevertheless, several reports suggest that neurons maintain the ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2017 - Elsevier BV | Experimental Cell Research
Hélder Fraga, Iñaki García de Cortázar Atauri, Aureliano C. Malheiro, José Moutinho‐Pereira, João A. Santos,
Aim: The winemaking sector in Portugal is of major socio-economic relevance, significantly contributing to the national exports and sustaining many wine-related activities, including oenotourism. Portuguese viticultural regions present a wide range of edaphoclimatic conditions with remarkable regional specificities, thus contributing to the individuality of their wines. Owing to the strong influence of climate and weather factors on grapevines, climate change may drive significant impacts on Portuguese ...
Tópico(s): Wine Industry and Tourism
2017 - ADERA | OENO One
Gabriele de Oliveira Custódio Pereira, Manuel Parente, João Moutinho, Manuel Sampaio,
Decision support and optimization tools to be used in construction often require an accurate estimation of the cost variables to maximize their benefit. Heavy machinery is traditionally one of the greatest costs to consider mainly due to fuel consumption. These typically diesel-powered machines have a great variability of fuel consumption depending on the scenario of utilization. This paper describes the creation of a framework aiming to estimate the fuel consumption of construction trucks depending ...
Tópico(s): Smart Agriculture and AI
2021 - Multidisciplinary Digital Publishing Institute | Infrastructures
Lia‐Tânia Dinis, Sara Bernardo, Chenyao Yang, Hélder Fraga, Aureliano C. Malheiro, José Moutinho‐Pereira, João A. Santos,
The exposure of viticulture to climate change and extreme weather conditions makes the winemaking sector particularly vulnerable, being one of its major challenges in the current century. While grapevine is considered a highly tolerant crop to several abiotic stresses, Mediterranean areas are frequently affected by adverse environmental factors, namely water scarcity, heat and high irradiance, and are especially vulnerable to climate change. Due to the high socio-economic value of this sector in ...
Tópico(s): Fermentation and Sensory Analysis
2022 - EDP Sciences | Ciência e técnica vitivinícola/Ciência e técnica vitivinícola
Carlos Conde, Mariana Osswald, João Barbosa, Tatiana Moutinho‐Santos, Diana Pinheiro, S. Guimarães, Irina Matos, Hélder Maiato, Cláudio E. Sunkel,
... author Author Information Carlos Conde 1,‡, Mariana Osswald1,‡, João Barbosa1, Tatiana Moutinho-Santos1, Diana Pinheiro1, Sofia Guimarães1, Irina Matos1, Helder ...
Tópico(s): Cellular transport and secretion
2013 - Springer Nature | The EMBO Journal
Produção Nacional
Revisado por pares
Sofia Vila Moutinho Tavares, João C. Tavares, Joana Borges Marques, Joana Teixeira de Figueiredo, Renato Lucas Passos de Souza,
Anorectal malformations are one of the most frequent congenital malformations treated by pediatric surgeons. In low-income countries, the surgical and anesthetic management of children in need of these procedures can be challenging. Limited oxygen supply, lack of equipment, especially pediatric, and intensive care units make the use of regional anesthesia appealing. We present a series of four cases of anorectal malformations corrections in Guinea Bissau, in children up to 13 months of age, under ...
Tópico(s): Anesthesia and Sedative Agents
2022 - Wiley | Pediatric Anesthesia
Víctor Moutinho, Carlos Costa, João Paulo Cerdeira Bento,
This study employs the decomposition analysis of CO2 emissions for the period from 2000 to 2012. This technique computes five effects that drive changes in CO2 emissions in five subsectors of the Portuguese tourism industry. The energy over fixed capital, the capital over labour productivity, and the tourism intensity are the most important effects in accommodation, food and beverage services. The carbonisation index constitutes an important effect in transports. The capital over labour productivity ...
Tópico(s): Climate Change Policy and Economics
2015 - Elsevier BV | Tourism Management Perspectives
Mario Krenn, Lorenzo Buffoni, Bruno Coutinho, Sagi Eppel, Jacob G. Foster, Andrew Gritsevskiy, Harlin Lee, Yichao Lu, João P. Moutinho, Nima Sanjabi, Rishi Sonthalia, Ngoc Mai Tran, Francisco Valente, Yangxinyu Xie, Rose Yu, Michael Kopp,
Abstract A tool that could suggest new personalized research directions and ideas by taking insights from the scientific literature could profoundly accelerate the progress of science. A field that might benefit from such an approach is artificial intelligence (AI) research, where the number of scientific publications has been growing exponentially over recent years, making it challenging for human researchers to keep track of the progress. Here we use AI techniques to predict the future research ...
Tópico(s): Advanced Graph Neural Networks
2023 - Nature Portfolio | Nature Machine Intelligence
João P. Moutinho, André Melo, Bruno Coutinho, I. Kovács, Yasser Omar,
Predicting new links in physical, biological, social, or technological networks has a significant scientific and societal impact. Path-based link prediction methods utilize the explicit counting of even- and odd-length paths between nodes to quantify a score function and infer new or unobserved links. Here, we propose a quantum algorithm for path-based link prediction using a controlled continuous-time quantum walk to encode even and odd path-based prediction scores. Through classical simulations ...
Tópico(s): Complex Network Analysis Techniques
2023 - American Physical Society | Physical review. A/Physical review, A
Ângela Martins, Vera Neves, João P. Moutinho, Nélson Nunes, Ana P. Carvalho,
Friedel-Crafts acylation reaction was studied under mild conditions using hierarchical HY zeolite samples prepared through surfactant mediated technology, in the presence of NH4OH, using CTAB or DTAB as surfactants and changing the duration of treatment from 6 to 48 h. The materials were characterized by powder X-ray diffraction, low temperature N2 adsorption isotherms, SEM microscopy and pyridine adsorption followed by FTIR. The catalytic behaviour was studied in the acylation of furan by acetic ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2021 - Elsevier BV | Microporous and Mesoporous Materials
Víctor Moutinho, Mara Madaleno, João Paulo Cerdeira Bento,
Tópico(s): Monetary Policy and Economic Impact
2020 - Springer Science+Business Media | Environmental and Ecological Statistics