Cristina Jácome, Ana Margarida Pereira, Rute Almeida, Manuel Ferreira‐Magalhães, Mariana Couto, Luís Araújo, Mariana Pereira, Magna Alves‐Correia, Cláudia Chaves Loureiro, Maria Joana Catarata, Lília Maia Santos, João Gonçalves-Pereira, Bárbara Ramos, Cristina Lopes, Ana Mendes, José Carlos Cidrais Rodrigues, Georgeta Oliveira, Ana Paula Aguiar, Ivete Afonso, Joana Carvalho, Ana Arrobas, José Coutinho Costa, Joana Alves Dias, Ana Todo‐Bom, João Azevedo, Carmelita Ribeiro, Marta Alves, Paula Pinto, Nuno Neuparth, Ana Palhinha, João Gaspar Marques, Nicole Pinto, Pedro Martins, Filipa Todo Bom, Maria Alvarenga Santos, Alberto Costa, Armandina Silva Neto, Marta Santalha, Carlos Lozoya, Natacha Santos, Diana Silva, Maria João Vasconcelos, Luís Taborda‐Barata, Célia Carvalhal, Maria Fernanda Teixeira, Rodrigo Rodrigues Alves, Ana Sofia Moreira, Cláudia Sofia Pinto, Pedro Morais Silva, Carlos Alves, Raquel Câmara, Didina Coelho, Diana Bordalo, Ricardo M. Fernandes, Rosário Ferreira, Fernando Menezes, Ricardo Gomes, Maria José Cálix, Ana Marques, João Cardoso, Madalena Emiliano, Rita Gerardo, Carlos Nunes, Rita Câmara, José Alberto Ferreira, Aurora Carvalho, Paulo Freitas, Ricardo Cruz‐Correia, João Fonseca,
We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.Baseline data from two prospective multicentre observational studies.29 allergy, pulmonology and paediatric secondary care outpatient clinics in Portugal.395 patients (≥13 years old) with persistent asthma.Data on demographics, patient-physician relationship, upper airway control, asthma control, asthma treatment, forced expiratory volume in one second (FEV1) ...
Tópico(s): Cystic Fibrosis Research Advances
2019 - BMJ | BMJ Open
Produção Nacional
Revisado por pares
Ana Carolina Proença da Fonseca, Gabriella de Medeiros Abreu, Lohanna Palhinha, Verônica Marques Zembrzuski, Mário Campos, João Régis Ivar Carneiro, José Firmino Nogueira Neto, Fernanda Cristina Carvalho Mattos Magno, Eliane Lopes Rosado, Clarissa M. Maya‐Monteiro, Giselda Maria Kalil de Cabello, Pedro Hernán Cabello, Patrı́cia T. Bozza,
Brain-derived neurotrophic factor (BDNF) is a pro-survival factor in the brain that also regulates energy balance. BDNF loss-of-function point mutations are responsible for haploinsufficiency, causing severe early-onset obesity. Up to date, only a few studies have sequenced this gene to search for rare mutations related to obesity. In this study, we aimed to investigate the prevalence of BDNF variants in a cohort of adults with severe obesity from Brazil.This study comprised 201 adults with severe ...
Tópico(s): Protein Degradation and Inhibitors
2021 - Dove Medical Press | Diabetes Metabolic Syndrome and Obesity
Cristina Jácome, Rute Almeida, Ana Margarida Pereira, Rita Amaral, Sandra Mendes, Magna Alves‐Correia, Carmen Vidal, Sara López Freire, P. Méndez Brea, Luís Araújo, Mariana Couto, Dario Antolín‐Amérigo, B. de la Hoz, Alicia Barra Castro, David González‐de‐Olano, Ana Todo‐Bom, João Azevedo, Paula Pinto, Nicole Pinto, Ana Castro Neves, Ana Palhinha, Filipa Todo Bom, Alberto Costa, Cláudia Chaves Loureiro, Lília Maia Santos, Ana Arrobas, Margarida Valério, João Cardoso, Madalena Emiliano, Rita Gerardo, José Carlos Cidrais Rodrigues, Georgeta Oliveira, Joana Carvalho, Ana Mendes, Carlos Lozoya, Natacha Santos, Fernando Menezes, Ricardo Gomes, Rita Câmara, Rodrigo Rodrigues Alves, Ana Sofia Moreira, Diana Bordalo, Carlos Alves, José Alberto Ferreira, Cristina Lopes, Diana Silva, Maria João Vasconcelos, Maria Fernanda Teixeira, Manuel Ferreira‐Magalhães, Luís Taborda‐Barata, Maria José Cálix, Adelaide Alves, João Fonseca,
Poor medication adherence is a major challenge in asthma, and objective assessment of inhaler adherence is needed. The InspirerMundi app aims to monitor adherence while providing a positive experience through gamification and social support.
Tópico(s): Medication Adherence and Compliance
2021 - JMIR Publications | JMIR mhealth and uhealth
Produção Nacional
Revisado por pares
Jairo R. Temerozo, Natália Fintelman-Rodrigues, Monique Cristina dos Santos, Eugênio D. Hottz, Carolina Q. Sacramento, Aline de Paula Dias da Silva, Samuel Coelho Mandacaru, Emilly Caroline dos Santos Moraes, Monique R. O. Trugilho, João Silveira Moledo Gesto, Marcelo Alves Ferreira, Felipe Saraiva, Lohanna Palhinha, Remy Martins-Gonçalves, Isaclaudia G. Azevedo-Quintanilha, Juliana L. Abrantes, Cássia Righy, Pedro Kurtz, Hui Jiang, Hongdong Tan, Carlos Morel, Dumith Chequer Bou‐Habib, Fernando A. Bozza, Patrı́cia T. Bozza, Thiago Moreno L. Souza,
Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely to die than the general population. Although progression from mild to severe COVID-19 has been associated with hypoxia, uncontrolled inflammation, and coagulopathy, the mechanisms involved in the progression to severity are poorly understood.The virome of tracheal aspirates (TA) from 25 COVID-19 patients under IMV was assessed through unbiased RNA sequencing (RNA-seq), ...
Tópico(s): Cytomegalovirus and herpesvirus research
2022 - BioMed Central | Microbiome
Cristina Jácome, Ana Margarida Pereira, Rute Almeida, Rita Amaral, Magna Alves‐Correia, Sandra Mendes, Pedro Vieira‐Marques, José Alberto Ferreira, Inês Lopes, Jancarlo Ferreira Gomes, Carmen Vidal, Sara López Freire, P. Méndez Brea, A Arrobas, Margarida Valério, Cláudia Chaves Loureiro, LM Santos, Mariana Couto, Luís Araújo, Ana Todo‐Bom, João Azevedo, João Cardoso, Madalena Emiliano, Rita Gerardo, Carlos Lozoya, P L Pinto, Ana Castro Neves, Nicole Pinto, Ana Palhinha, F. Teixeira, Manuel Ferreira‐Magalhães, Crésio Alves, Denise Falcão Costa Coelho, Natacha Santos, Fernando Menezes, Ricardo Gomes, J C Cidrais Rodrigues, Georgeta Oliveira, JOÃO VICTOR DOS SANTOS DOS SANTOS CARVALHO, Rodrigo Rodrigues Alves, A S Moreira, Alberto Costa, Carmo Abreu, Rui Silva, Ana Morête, Helena Falcão, Maria Luís Marques, Raquel Câmara, M José Cálix, Diana Bordalo, D Silva, M J Vasconcelos, Ricardo M. Fernandes, Rosário Ferreira, P Freitas, Fernanda Degobbi Tenório Quirino dos Santos Lopes, João Fonseca,
Supplementary Figure 3. Bland-Altman plots of Control of Allergic Rhinitis and Asthma Test (CARAT) sub scores (upper airways CARAT-UA and lower airways CARAT-LA) obtained through paper (pCARAT), app (mCARAT) and telephone (tCARAT) *The dashed lines represent the bias and the dot-dashed lines the 95% limits of agreement
Tópico(s): Allergic Rhinitis and Sensitization
2020 - ESMON Publicidad | Journal of Investigational Allergology and Clinical Immunology
Cristina Jácome, Rute Almeida, Ana Margarida Pereira, Luís Araújo, Magna Alves‐Correia, Ana Margarida Pereira, Mariana Couto, Cristina Lopes, Cláudia Chaves Loureiro, Maria Joana Catarata, LM Santos, B Ramos, Ana Mendes, E Pedro, J C Cidrais Rodrigues, Georgeta Oliveira, AP Aguiar, AM Arrobas, José Coutinho Costa, Juliana Rocha Pinto Dias, Ana Todo‐Bom, João Azevedo, Carlos Antônio Álvares Soares Ribeiro, Marta Alves, PL Pinto, Nuno Neuparth, Ana Palhinha, J.G. Marques, Patricia Lustosa Martins, David Trincão, Ana Castro Neves, Filipa Todo Bom, Santos Ma, Jaime Branco, Carlos Lozoya, Alberto Costa, Armandina Silva Neto, D Silva, M J Vasconcelos, MF Teixeira, Manuel Ferreira‐Magalhães, Luís Taborda‐Barata, Cíntia Iara Oda Carvalhal, Natacha Santos, Cláudia Sofia Pinto, Rodrigo Rodrigues Alves, AS Moreira, P Morais Silva, Ricardo M. Fernandes, Rosário Ferreira, Carlos Alves, Raquel Câmara, J Ferraz de Oliveira, Diana Bordalo, M José Cálix, Alda Marques, Carlos Nunes, Fernando Menezes, Ricardo Gomes, João Fonseca,
Tópico(s): Digital Mental Health Interventions
2019 - ESMON Publicidad | Journal of Investigational Allergology and Clinical Immunology
Produção Nacional
Cristina Jácome, Rita Amaral, Rute Almeida, Ana Margarida Pereira, Mariana Couto, Luís Araújo, Magna Alves‐Correia, Mariana Pereira, Manuel Ferreira‐Magalhães, Cláudia Chaves Loureiro, Maria Joana Catarata, Lília Maia Santos, S. Cabral, João Gonçalves-Pereira, Bárbara Ramos, Cristina Lopes, Ana Beatriz Valverde Mendes, Anabela Lopes, José Carlos Cidrais Rodrigues, Georgeta Oliveira, Ana Paula Aguiar, Ivete Afonso, Joana Carvalho, Ana Arrobas, José Coutinho Costa, Margarida Valério, Marta Pereira, Teresa Almeida, Joana Alves Dias, Ana Todo‐Bom, João Azevedo, Carmelita Ribeiro, Marta Alves, Paula Pinto, Nuno Neuparth, Ana Castro Neves, Ana Palhinha, João Gaspar Marques, Pedro Martins, David Trincão, Filipa Todo Bom, Maria João Heitor, Joana Branco, Alberto Costa, Armandina Silva Neto, Marta Santalha, Carlos Lozoya, Natacha Santos, Diana Silva, Maria João Vasconcelos, Luís Taborda‐Barata, Maria Fernanda Teixeira, Diana Pinto, Rodrigo Rodrigues Alves, Ana Sofia Moreira, Cláudia Sofia Pinto, Pedro Silva, Carlos Alves, Raquel Câmara, Didina Coelho, Diana Bordalo, Fernanda Caroline Carvalho, Ricardo M. Fernandes, Rosário Ferreira, José Ferraz de Oliveira, Fernando Menezes, Ricardo Gomes, Maria José Cálix, Ana Marques, João Cardoso, Madalena Emiliano, Rita Gerardo, Carlos Nunes, José Alberto Ferreira, Inês Lopes, Adelaide Alves, João Fonseca,
Aims: To identify distinct asthma control clusters based on Control of Allergic Rhinitis and Asthma Test (CARAT) and to compare patients’ characteristics among these clusters. Methods: Adults and adolescents (≥13 years) with persistent asthma were recruited at 29 Portuguese hospital outpatient clinics, in the context of two observational studies of the INSPIRERS project. Demographic and clinical characteristics, adherence to inhaled medication, beliefs about inhaled medication, anxiety and depression, ...
Tópico(s): Allergic Rhinitis and Sensitization
2020 - | Revista Portuguesa de Imunoalergologia
Produção Nacional
Revisado por pares
Kaio Cezar Rodrigues Salum, Guilherme Orofino de Souza, Gabriella de Medeiros Abreu, Mário Campos, Fabiana B. Kohlrausch, João Régis Ivar Carneiro, José Firmino Nogueira Neto, Fernanda Cristina Carvalho Mattos Magno, Eliane Lopes Rosado, Lohanna Palhinha, Clarissa M. Maya‐Monteiro, Giselda Maria Kalil de Cabello, Pedro Hernán Cabello, Patrı́cia T. Bozza, Verônica Marques Zembrzuski, Ana Carolina Proença da Fonseca,
The melanocortinergic pathway orchestrates the energy homeostasis and impairments in this system often lead to an increase in body weight. Rare variants in the melanocortin 4 receptor (MC4R) gene resulting in partial or complete loss of function have been described with autosomal co-dominant inheritance. These mutations are the most common cause of non-syndromic monogenic obesity. In this context, this study aimed to sequence the MC4R gene in a Brazilian cohort of adults with severe obesity.This ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2020 - Frontiers Media | Frontiers in Genetics
Produção Nacional
Revisado por pares
Ana Carolina Proença da Fonseca, Izadora Sthephanie da Silva Assis, Kaio Cezar Rodrigues Salum, Lohanna Palhinha, Gabriella de Medeiros Abreu, Verônica Marques Zembrzuski, Mário Campos, José Firmino Nogueira Neto, Fernanda Cristina C. Mattos, Amanda Cambraia, Eliane Lopes Rosado, Clarissa M. Maya‐Monteiro, Pedro Hernán Cabello, João Régis Ivar Carneiro, Patrı́cia T. Bozza,
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2022 - Springer Science+Business Media | Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity
Tiago Peres, João Silva, Pedro F. Silva, Duarte Carona, António Serrador, Filipe Palhinha, Ricardo Lopes Pereira, Mário Véstias,
Abstract. The upcoming Galileo system opens a wide range of new opportunities in the Global Navigation Satellite System (GNSS) market. However, the characteristics of the future GNSS signals require the development of new GNSS receivers. In the frame of the REAGE project, DEIMOS and ISEL have developed a GNSS receiver targeted for aerospace applications, supporting current and future GPS L1 and Galileo E1 signals, based on commercial (or, in the furthest extent, industrial) grade components. Although ...
Tópico(s): Astronomical Observations and Instrumentation
2014 - Copernicus Publications | The international archives of the photogrammetry, remote sensing and spatial information sciences/International archives of the photogrammetry, remote sensing and spatial information sciences
Produção Nacional
Revisado por pares
Lívia Teixeira, Jairo R. Temerozo, Filipe S. Pereira‐Dutra, André C. Ferreira, Mayara Mattos, Barbara Simonson Gonçalves, Carolina Q. Sacramento, Lohanna Palhinha, Tamires Cunha‐Fernandes, Suelen da Silva Gomes Dias, Vinícius Cardoso Soares, Ester A. Barreto, Daniella Cesar-Silva, Natália Fintelman-Rodrigues, Camila R. R. Pão, Caroline S. de Freitas, Patrícia A. Reis, Eugênio D. Hottz, Fernando A. Bozza, Dumith Chequer Bou‐Habib, Elvira M. Saraiva, Cecília J. G. de Almeida, João P. B. Viola, Thiago Moreno L. Souza, Patrı́cia T. Bozza,
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical studies, statins have been identified as beneficial to hospitalized patients with COVID-19. However, experimental evidence of underlying statins protection against SARS-CoV-2 remains elusive. Here we reported for the first-time experimental evidence of the protective effects of simvastatin treatment both in vitro and in vivo . We found ...
Tópico(s): Inflammasome and immune disorders
2022 - Frontiers Media | Frontiers in Immunology
Filipe Palhinha, Ricardo Lopes Pereira, Duarte Carona, António Serrador, Mário Véstias, João Silva, Tiago Peres, Pedro Silva,
Abstract The upcoming Galileo system opens a wide range of new opportunities in the Global Navigation Satellite System (GNSS) market. However, the characteristics of the future signals require the development of new GNSS receivers. This paper presents the devel- oped GNSS receiver architecture (including the Radio Frequency (RF) Front-End and the baseband Hardware (HW) platform), and describes the development of the experimental Global Positioning System (GPS)/Galileo L1/E1 RF Front-End (based on Maxim' ...
Tópico(s): Satellite Communication Systems
2014 - Elsevier BV | Procedia Technology
Estrela Figueiredo, Vasco Silva, Gideon F. Smith,
... Avelar Brotero. Arq. Univ. Lisboa 5: 75– 98. Palhinha, R.T. 1944. Félix de Avellar Brotero: O ...
Tópico(s): Plant Diversity and Evolution
2018 - Wiley | Taxon
Produção Nacional
Revisado por pares
Ana Carolina Proença da Fonseca, Izadora Sthephanie da Silva Assis, Kaio Cezar Rodrigues Salum, Lohanna Palhinha, Gabriella de Medeiros Abreu, Verônica Marques Zembrzuski, Mário Campos, José Firmino Nogueira-Neto, Amanda Cambraia, Mauro Lucio Ferreira Souza, Clarissa M. Maya‐Monteiro, Pedro Hernán Cabello, Patrı́cia T. Bozza, João Régis Ivar Carneiro,
Introduction Obesity is a multifactorial disease associated with the development of many comorbidities. This disease is associated with several metabolic alterations; however, it has been shown that some individuals with obesity do not exhibit metabolic syndrome. Adipose tissue neutralizes the detrimental effects of circulating fatty acids, ectopic deposition, and inflammation, among others, through its esterification into neutral lipids that are stored in the adipocyte. However, when the adipocyte ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2024 - Frontiers Media | Frontiers in Genetics
G. Garuti, A. Nicolini, Bruna Grecchi, M. Lusuardi, João Carlos Winck, John R. Bach,
... 15 e 22 mm e as de tipo «palhinha». A VNI através de de peça bucal é ...
Tópico(s): Nosocomial Infections in ICU
2014 - Elsevier BV | Revista Portuguesa de Pneumologia
Núria Garcia‐Jacas, Alfonso Susanna,
... Portugal, Algarve], Monchique, Moinho do Peso, Jul 1924, Palhinha (LISU No. P-39238). (H) Centaurea crocata Gand., Obs. Centaurea: 13. Oct 1873, nom. rej. prop. Lectotypus (hic designatus): [France], St. Bonnet-sur-Montmelas (Rhône), 26 Jul 1869, Gandoger 3 (LY barcode LY0004276). Centaurea crocata Franco (Nova Fl. Portugal 2: 572. 1984) was published by João do Amaral Franco to accommodate a rare species ...
Tópico(s): Mediterranean and Iberian flora and fauna
2020 - Wiley | Taxon
Produção Nacional
Revisado por pares
Izadora Sthephanie da Silva Assis, Kaio Cezar Rodrigues Salum, Rafaela de Freitas Martins Felício, Lohanna Palhinha, Gabriella de Medeiros Abreu, Tamara Silva, Fernanda Mattos, Eliane Lopes Rosado, Verônica Marques Zembrzuski, Mário Campos, Clarissa M. Maya‐Monteiro, Pedro Hernán Cabello, João Régis Ivar Carneiro, Patrı́cia T. Bozza, Ana Carolina Proença da Fonseca,
Introduction Genetic obesity is considered a rare disease, affecting up to 10% of patients with severe early-onset obesity. Over the past years, significant advances have been made; however, the majority of patients are misdiagnosed with polygenic obesity. Thus, this study aimed to identify deleterious copy number variations (CNVs) linked to obesity and explore the clinical phenotypes. Method The sample comprised 195 adults with severe obesity (BMI≥35kg/m 2 ) who developed this phenotype during childhood ...
Tópico(s): Pancreatic function and diabetes
2025 - Frontiers Media | Frontiers in Endocrinology
Produção Nacional
Revisado por pares
Kaio Cezar Rodrigues Salum, Izadora Sthephanie da Silva Assis, Úrsula de Almeida Kopke, Lohanna Palhinha, Gabriella de Medeiros Abreu, Laura Wendling Gouvêa, Michelle Dias de Oliveira Teixeira, Fernanda Cristina C. Mattos, José Firmino Nogueira Neto, Rafaela de Freitas Martins Felício, Eliane Lopes Rosado, Verônica Marques Zembrzuski, Mário Campos, Clarissa M. Maya‐Monteiro, Pedro Hernán Cabello, João Régis Ivar Carneiro, Patrı́cia T. Bozza, Fabiana B. Kohlrausch, Ana Carolina Proença da Fonseca,
Tópico(s): Obesity, Physical Activity, Diet
2025 - Dove Medical Press | Diabetes Metabolic Syndrome and Obesity