Produção Nacional
Revisado por pares
André Ferreira Rodrigues, Carlos Rogério de Mello, Udo Nehren, João Pedro de Coimbra Ribeiro, Vanessa Alves Mantovani, José Márcio de Mello,
Modeling canopy interception is fundamental for understanding the forests’ role in local and regional hydrology. In this study, canopy interception (CI), throughfall (TF), and stemflow (SF) were evaluated for a semi-deciduous Atlantic Forest (AFR) from 2013 to 2019, where a prolonged dry period occurred. The Gash and Liu models were analyzed in detail to determine the most appropriate for modeling CI throughout drought conditions. Thus, the climatic parameters were retrieved annually by a modified TF- ...
Tópico(s): Remote Sensing in Agriculture
2021 - Elsevier BV | Journal of Environmental Management
Paulo Bettencourt, João Ferreira‐Coimbra, Pedro Rodrigues, Pedro Marques, Helena Moreira, Maria João Pinto, João Tiago Guimarães, Patrícia Lourenço,
Abstract Aims Growth differentiation factor (GDF)‐15 mirrors inflammation and oxidative stress in cardiovascular diseases. Brain natriuretic peptide (BNP) is associated with cardiomyocyte stretch in heart failure (HF). The objective of this study was to evaluate the prognostic impact of plasma GDF‐15 and BNP in acute HF. Methods and results We studied a subgroup of patients prospectively recruited in an acute HF registry (follow‐up: 2 years; endpoint: all‐cause mortality). Cox regression multivariate ...
Tópico(s): Heart Failure Treatment and Management
2018 - Wiley | ESC Heart Failure
Rufino Silva, Luís Arias, Sandrina Nunes, Cláudia Farinha, Rita Coimbra, João Pedro Marques, Maria Luz Cachulo, João Figueira, Patrícia Barreto, Maria Madeira, Isabel Pires, João Paulo Castro Sousa, Laura Distéfano, Paulo Caldeira Rosa, Ângela Carneiro, Sara Vaz-Pereira, Angelina Meireles, Francisco Cabrera López, Anniken Burés, Luís Mendonça, Alvaro Fernandez-Vega-Sanz, Sandra Barrão, Adrian Koh, Chui Ming Gemmy Cheung, José Cunha‐Vaz, Joaquim Murta,
<b><i>Importance:</i></b> Polypoidal choroidal vasculopathy (PCV) is far less common and studied in a Caucasian population than in an Asian population, and the optimal treatment approach remains to be confirmed. <b><i>Methods:</i></b> A 52-week, double-masked, sham-controlled, phase 4, investigator-initiated randomized clinical trial (RCT) in naive symptomatic Caucasian patients with PCV treated with aflibercept in a treat-and-extend regimen (T&E) ( ...
Tópico(s): Retinal and Optic Conditions
2021 - Karger Publishers | Ophthalmologica
Sérgio F. Sousa, Gaspar Pinto, António J. M. Ribeiro, João T. S. Coimbra, Pedro Alexandrino Fernandes, Maria J. Ramos,
In this study, a set of 50 transition‐metal complexes of Cu(I) and Cu(II), were used in the evaluation of 18 density functionals in geometry determination. In addition, 14 different basis sets were considered, including four commonly used Pople's all‐electron basis sets; four basis sets including popular types of effective‐core potentials: Los Alamos, Steven‐Basch‐Krauss, and Stuttgart‐Dresden; and six triple‐ζ basis sets. The results illustrate the performance of different methodological alternatives ...
Tópico(s): X-ray Diffraction in Crystallography
2013 - Wiley | Journal of Computational Chemistry
Produção Nacional
Revisado por pares
Tauana Bernardes Leoni, Carelis González‐Salazar, Thiago Junqueira Ribeiro de Rezende, Ana Luisa Hernandez, Alexandre Hilário B. Mattos, Antônio Rodrigues Coimbra Neto, Felipe Franco da Graça, João Pedro Nunes Gonçalves, Alberto Martínez, Lucas Mitsuo Taniguti, João Paulo Kitajima, Fernando Kok, Fábio Rogério, André Macedo Serafim Silva, Alexandre Leite Rodrigues de Oliveira, Edmar Zanoteli, Anamarli Nucci, Marcondes C. França,
Protein misfolding plays a central role not only in amyotrophic lateral sclerosis (ALS), but also in other conditions, such as frontotemporal dementia (FTD), inclusion body myopathy (hIBM) or Paget's disease of bone. The concept of multisystem proteinopathies (MSP) was created to account for those rare families that segregate at least 2 out of these 4 conditions in the same pedigree. The calcium-dependent phospholipid-binding protein annexin A11 was recently associated to ALS in European pedigrees. ...
Tópico(s): Alzheimer's disease research and treatments
2021 - Wiley | Annals of Neurology
Jorge Canena, David Horta, João Coimbra, Liliane Meireles, Pedro Russo, Inês Marques, Leonel Ricardo, Catarina Rodrigues, Tiago Lima Capela, Diana Carvalho, Rafaela Loureiro, António Mateus Dias, Gonçalo Ramos, António Pereira Coutinho, Carlos Romão, Pedro Mota Veiga,
Biliary leaks have been treated with endoscopic management using different techniques with conflicting results. Furthermore the appropriate rescue therapy for refractory leaks has not been established. We evaluated the clinical effectiveness of initial endotherapy for postcholecystectomy biliary leaks using an homogenous approach (sphincterotomy + placement of a 10-French plastic stent) in a large series of patients as well as the optimal and efficacy of rescue endotherapy for refractory biliary leaks. ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2015 - BioMed Central | BMC Gastroenterology
João T. S. Coimbra, Pedro Alexandrino Fernandes, Maria J. Ramos,
We discuss potential-of-mean force convergence issues involving the methods for generating starting structures of umbrella sampling simulations for the study of the water-bilayer permeation of drug-like compounds. We provide a proof of concept of the benefits of potential-energy modification methods, in particular the flooding technique, to enhance the sampling and improve the convergence of the potential-of-mean force. In addition, we also discuss how these potential modifiers could introduce the ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2017 - American Chemical Society | Journal of Chemical Theory and Computation
Produção Nacional
Revisado por pares
João Pedro Souza‐Alves, Renata R. D. Chagas, Marina M. Santana, Sarah A. Boyle, Bruna M. Bezerra,
There is wide variability in primate behavior and ecology. Understanding how frugivorous primates behave under different habitat fragmentation levels is key for effective conservation and management of species and their habitats. We evaluated the seasonality in activity budget, diet, and ranging behavior of two groups of Endangered Coimbra-Filho's titi monkeys (Callicebus coimbrai). One group inhabited a 14-ha forest fragment, whereas the other lived in a 522-ha fragment. We measured the monthly ...
Tópico(s): Animal Vocal Communication and Behavior
2021 - Wiley | American Journal of Primatology
Ana Gonçalves, João V. Neves, J. Coimbra, Pedro Rodrigues, Mathilakath M. Vijayan, Jonathan M. Wilson,
Exposure to high environmental ammonia (HEA) levels increases the vulnerability of fishes to parasitic, viral and bacterial diseases. We tested the hypothesis that elevated plasma cortisol levels play a role in the HEA-mediated immunosuppression in fishes. To this end, we tested the effect of exogenous cortisol treatment on the lipopolysaccharide (LPS)-induced immune response in zebrafish (Danio rerio). Also, to test whether glucocorticoid receptor (GR) signaling is involved in HEA-mediated immunosuppression, ...
Tópico(s): Invertebrate Immune Response Mechanisms
2017 - Elsevier BV | General and Comparative Endocrinology
Produção Nacional
Revisado por pares
Sueli Rizzutti, Viviane Schuch, Bruno Muszkat Augusto, Caio Colturato Coimbra, João Pedro Cabrera Pereira, Orlando Francisco Amodeo Bueno,
Attention-deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder that implies several-step process, and there is no single test to diagnose both ADHD and associated comorbidities, such as oppositional-defiant disorder (ODD), anxiety disorder, depression, and certain types of learning disabilities. The purpose of the present study was to examine correlations between behavioral and clinical symptoms by administering an extensive neuropsychological battery to a sample of children ...
Tópico(s): Functional Brain Connectivity Studies
2015 - Frontiers Media | Frontiers in Psychiatry
Gerardo J. Osório, Miadreza Shafie‐khah, Pedro D. L. Coimbra, Mohamed Lotfi, João P. S. Catalào,
Electric vehicles (EVs) promote many advantages for distribution systems such as increasing efficiency and reliability, decreasing dependence on non-endogenous resources, and reducing pollutant emissions. Due to increased proliferation of EVs and their integration in power systems, management and operation of distribution systems (ODS) is becoming more important. Recent studies have shown that EV can increase power grid flexibility since EV owners do not use them for 93–96% of the daytime. Therefore, ...
Tópico(s): Electric and Hybrid Vehicle Technologies
2018 - Multidisciplinary Digital Publishing Institute | Energies
Irina S. Moreira, João M. Martins, João T. S. Coimbra, Maria J. Ramos, Pedro Alexandrino Fernandes,
Protein-protein (P-P) 3D structures are fundamental to structural biology and drug discovery. However, most of them have never been determined. Many docking algorithms were developed for that purpose, but they have a very limited accuracy in generating native-like structures and identifying the most correct one, in particular when a single answer is asked for. With such a low success rate it is difficult to point out one docked structure as being native-like. Here we present a new, high accuracy, ...
Tópico(s): Machine Learning in Bioinformatics
2014 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Inês C. M. Simões, Inês P. D. Costa, João T. S. Coimbra, Maria J. Ramos, Pedro Alexandrino Fernandes,
Knowing how proteins make stable complexes enables the development of inhibitors to preclude protein-protein (P:P) binding. The identification of the specific interfacial residues that mostly contribute to protein binding, denominated as hot spots, is thus critical. Here, we refine an in silico alanine scanning mutagenesis protocol, based on a residue-dependent dielectric constant version of the Molecular Mechanics/Poisson-Boltzmann Surface Area method. We have used a large data set of structurally ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2016 - American Chemical Society | Journal of Chemical Information and Modeling
Rui P. Ribeiro, João T. S. Coimbra, Maria J. Ramos, Pedro Alexandrino Fernandes,
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2017 - Springer Science+Business Media | Theoretical Chemistry Accounts
Cláudia Farinha, Maria Luz Cachulo, Rita Coimbra, Dalila Alves, Sandrina Nunes, Isabel Pires, João Pedro Marques, José Coutinho Costa, Amélia Martins, Isa Sobral, Patrícia Barreto, Inês Laíns, João Figueira, Luísa Ribeiro, José Cunha‐Vaz, Rufino Silva,
Epidemiology of age-related macular degeneration (AMD) is based on staging systems relying on color fundus photography (CFP). We aim to compare AMD staging using CFP to multimodal imaging with optical coherence tomography (OCT), infra-red (IR), and fundus autofluorescence (FAF), in a large cohort from the Epidemiologic AMD Coimbra Eye Study. All imaging exams from the participants of this population-based study were classified by a central reading center. CFP images were graded according to the International ...
Tópico(s): Retinal and Optic Conditions
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Luís Cruz, Eduardo Barata, João Pedro Ferreira, Fausto Freire,
Purpose This paper aims to explore the potential contribution of integrated traffic and parking management strategies to ensure more rational use of available parking spaces and to reduce fuel consumption and greenhouse gas emissions by commuters traveling to the University of Coimbra (UC) main campus. Design/methodology/approach An integrated modelling approach is used, including the characterization of supply and demand for parking and public transport, the creation and implementation of a survey ...
Tópico(s): Transportation Planning and Optimization
2017 - Emerald Publishing Limited | International Journal of Sustainability in Higher Education
Fernando Alexandre, Pedro Bação, João Cerejeira, Miguel Portela,
In this paper, we compute and compare aggregate and sector-specific exchange rate indexes for the Portuguese economy. We find that alternative effective exchange rate indexes are very similar between them. We also find that sector-specific effective exchange rates are strongly correlated with aggregate indexes. Nevertheless, we show that sector-specific exchange rates are more informative than aggregate exchange rates in explaining changes in employment: whereas aggregate indexes are statistically ...
Tópico(s): Economic theories and models
2009 - Coimbra University Press | Notas Económicas
Produção Nacional
Revisado por pares
Antonio J. Fontenele, Nivaldo A. P. de Vasconcelos, Thaís Feliciano, Leandro A. A. Aguiar, Carina Soares‐Cunha, Bárbara Coimbra, Leonardo Dalla Porta, Sidarta Ribeiro, Ana João Rodrigues, Nuno Sousa, Pedro V. Carelli, Mauro Copelli,
Since the first measurements of neuronal avalanches, the critical brain hypothesis has gained traction. However, if the brain is critical, what is the phase transition? For several decades, it has been known that the cerebral cortex operates in a diversity of regimes, ranging from highly synchronous states (with higher spiking variability) to desynchronized states (with lower spiking variability). Here, using both new and publicly available data, we test independent signatures of criticality and show ...
Tópico(s): stochastic dynamics and bifurcation
2019 - American Physical Society | Physical Review Letters
Produção Nacional
Revisado por pares
Nastaran Lotfi, Antonio J. Fontenele, Thaís Feliciano, Leandro A. A. Aguiar, Nivaldo A. P. de Vasconcelos, Carina Soares‐Cunha, Bárbara Coimbra, Ana João Rodrigues, Nuno Sousa, Mauro Copelli, Pedro V. Carelli,
It has recently been reported that statistical signatures of brain criticality, obtained from distributions of neuronal avalanches, can depend on the cortical state. We revisit these claims with a completely different and independent approach, employing a maximum entropy model to test whether signatures of criticality appear in urethane-anesthetized rats. To account for the spontaneous variation of cortical states, we parse the time series and perform the maximum entropy analysis as a function of ...
Tópico(s): stochastic dynamics and bifurcation
2020 - American Physical Society | Physical review. E
Cláudia Farinha, Ana Luísa Silva, Rita Coimbra, Sandrina Nunes, Maria Luz Cachulo, João Pedro Marques, Isabel Pires, José Cunha‐Vaz, Rufino Silva,
Tópico(s): Glaucoma and retinal disorders
2021 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
André Goulart, Carla Ferreira, Ana João Rodrigues, Bárbara Coimbra, Nuno Sousa, Pedro Leão,
Purpose: Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear.This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC.Methods: A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. ...
Tópico(s): Colorectal Cancer Surgical Treatments
2019 - | Annals of Surgical Treatment and Research
Luís M. C. Teixeira, João T. S. Coimbra, Maria J. Ramos, Pedro Alexandrino Fernandes,
Despite the development of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, there is an urgent need for efficient drugs to treat infected patients. An attractive drug target is the human transmembrane protease serine 2 (TMPRSS2) because of its vital role in the viral infection mechanism of SARS-CoV-2 by activation of the virus spike protein (S protein). Having in mind that the information derived from quantum mechanics/molecular mechanics (QM/MM) studies could ...
Tópico(s): Vitamin C and Antioxidants Research
2022 - American Chemical Society | Journal of Chemical Information and Modeling
Ana Gonçalves, Inês Páscoa, João V. Neves, J. Coimbra, Mathilakath M. Vijayan, Pedro Rodrigues, Jonathan M. Wilson,
Ammonia is a toxic by-product of amino acid catabolism and a common environmental pollutant that has been associated with increased disease susceptibility in fish although the mechanism is not well understood. We addressed the hypothesis that elevated environmental ammonia acts by impairing the acute phase response (APR). Specifically, we determined the impact of sub-lethal acute (24 h) and chronic (14 d) ammonia exposure on acute phase protein gene expression in zebrafish (Danio rerio) in response ...
Tópico(s): Fish Ecology and Management Studies
2011 - Elsevier BV | Developmental & Comparative Immunology
Produção Nacional
Revisado por pares
Carla F. Sousa, João T. S. Coimbra, Inês Gomes, Ricardo Franco, Pedro Alexandrino Fernandes, Paula Gameiro,
Bacterial resistance is a critical public health issue and the development of alternative antibiotics to counteract this problem is an urgent matter.
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2017 - Royal Society of Chemistry | RSC Advances
André M. N. Silva, Paulo R. H. Sousa, João T. S. Coimbra, Natércia F. Brás, Rui Vitorino, Pedro Alexandrino Fernandes, Maria J. Ramos, Maria Rangel, Pedro Domíngues,
The mechanisms involving iron toxicity in diabetes mellitus are not completely understood. However, the spontaneous reaction of reducing sugars with protein amino groups, known as glycation, has been shown to compromise the action of Tf (transferrin), the systemic iron transporter. In order to understand the structural alterations that impair its function, Tf was glycated in vitro and the modification sites were determined by MS. Iron binding to glycated Tf was assessed and a computational approach ...
Tópico(s): Hemoglobinopathies and Related Disorders
2014 - Portland Press | Biochemical Journal
Maria Paula Cabral Campello, Elisa Palma, Isabel Correia, Pedro M. R. Paulo, António Matos, José Rino, Joana Coimbra, João Costa Pessoa, Dinorah Gambino, António Paulo, Fernanda Marques,
The biological properties of four lanthanide complexes with phenanthroline derivatives in ovarian cancer cells.
Tópico(s): Radioactive element chemistry and processing
2019 - Royal Society of Chemistry | Dalton Transactions
Maria Oliveira, Filipe Coimbra, Pedro Mesquita, João Carvalho, Otília Lopes,
Aim: To characterize recurrent aphthous stomatitis in a young population and investigate the association between these lesions and predisposing factors, as well as potential modifications in children's daily routines. Methods:The data was collected by delivering a questionnaire to students attending S. Miguel Primary School, in Vizela, as well as to their parents/guardians.A literature review was conducted, using scientific databases such as PubMed, Cochrane and the Virtual Library of the University ...
Tópico(s): Skin and Cellular Biology Research
2018 - CIG Media Group | Revista Portuguesa de Estomatologia Medicina Dentária e Cirurgia Maxilofacial
Cláudia Farinha, Maria Luz Cachulo, Dalila Alves, Isabel Pires, João Pedro Marques, Patrícia Barreto, Sandrina Nunes, José Coutinho Costa, Amélia Martins, Isa Sobral, Inês Laíns, João Figueira, Luísa Ribeiro, José Cunha‐Vaz, Rufino Silva,
To describe the 6.5-year incidence and progression of age-related macular degeneration (AMD) in a coastal town of central Portugal.Population-based cohort study. Participants underwent standardized interviews and ophthalmological examination. Color fundus photographs were graded according to the International Classification and Grading System for AMD and ARM. The crude and age-standardized incidence of early and late AMD was calculated, and progression was analyzed.The 6.5-year cumulative incidence ...
Tópico(s): Glaucoma and retinal disorders
2019 - Karger Publishers | Ophthalmic Research
Produção Nacional
Revisado por pares
João T. S. Coimbra, Ralph Feghali, Rui P. Ribeiro, Maria J. Ramos, Pedro Alexandrino Fernandes,
Using computational strategies and an analogue compound, we explore and measure the impact of intramolecular hydrogen bonds on the translocation of the small drug piracetam, through biological membrane models.
Tópico(s): Neuroscience and Neuropharmacology Research
2021 - Royal Society of Chemistry | RSC Advances
Ran Friedman, Syma Khalid, Camilo Aponte‐Santamaría, Elena Arutyunova, Marlon Becker, Kevin J. Boyd, Mikkel Christensen, João T. S. Coimbra, Simona Concilio, Csaba Daday, Floris J. van Eerden, Pedro Alexandrino Fernandes, Frauke Gräter, Davit Hakobyan, Andreas Heuer, Konstantina Karathanou, Fabian Keller, M. Joanne Lemieux, Siewert J. Marrink, Eric R. May, Antara Mazumdar, Richard J Naftalin, Mónica Pickholz, Stefano Piotto, Peter Pohl, Peter J. Quinn, Maria J. Ramos, Birgit Schiøtt, Durba Sengupta, Lucia Sessa, Stefano Vanni, Talia Zeppelin, Valeria Zoni, Ana‐Nicoleta Bondar, Cármen Domene,
This is a perspective article entitled "Frontiers in computational biophysics: understanding conformational dynamics of complex lipid mixtures relevant to biology" which is following a CECAM meeting with the same name.
Tópico(s): Lipid metabolism and biosynthesis
2018 - Springer Science+Business Media | The Journal of Membrane Biology