João Pais, Pedro P. Cunha, D. I. Pereira, Paulo Legoinha, R. Dias, Delminda Moura, António Brum da Silveira, José Carlos Kullberg, José Ángel González Delgado,
The Portuguese mainland, located in western Iberia, represents a key area for understanding the evolution of the European Atlantic margin during the Cenozoic and the establishment of relations with the Mediterranean, in particular through the transition area between those two oceans which is well documented in the Algarve region.
Tópico(s): earthquake and tectonic studies
2011 - Springer International Publishing | SpringerBriefs in earth sciences
João Pedro Franco Pais, Artur M. S. Silva, Bruno Guimarães, Ana Povo, Elisabete Coelho, Fernanda Silva‐Pereira, Isabel Lourinho, Maria Amélia Ferreira, Mílton Severo,
The psychometric characteristics of multiple-choice questions (MCQ) changed when taking into account their anatomical sites and the presence of item-writing flaws (IWF). The aim is to understand the impact of the anatomical sites and the presence of IWF in the psychometric qualities of the MCQ.800 Clinical Anatomy MCQ from eight examinations were classified as standard or flawed items and according to one of the eight anatomical sites. An item was classified as flawed if it violated at least one of ...
Tópico(s): Medical Education and Admissions
2016 - BioMed Central | BMC Research Notes
Carolina Rivera Santiago, Teresa Rito, Daniel Vieira, Ticiana Fernandes, Célia Pais, Maria João Sousa, Pedro Soares, Ricardo Franco‐Duarte,
Saccharomyces cerevisiae is the most commonly used yeast in wine, beer, and bread fermentations. However, Torulaspora delbrueckii has attracted interest in recent years due to its properties, ranging from its ability to produce flavor- and aroma-enhanced wine to its ability to survive longer in frozen dough. In this work, publicly available genomes of T. delbrueckii were explored and their annotation was improved. A total of 32 proteins were additionally annotated for the first time in the type ...
Tópico(s): Horticultural and Viticultural Research
2021 - Multidisciplinary Digital Publishing Institute | Journal of Fungi
Fátima Falcão, E Viegas, Inês Carmo, Joana Soares, Margarida Falcao, Mariana Solano, Patrícia Cavaco, Dina Mendes, João Rijo, Pedro Póvoa, António Pais Martins, Eduarda Carmo, Kamal Mansinho, Cândida Fonseca, Luís Campos, António Carvalho, Ana Mirco, Helena Farinha, Isabel Aldir, José Manuel Correia,
Since the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pressure to minimise its impact on public health has led to the implementation of different therapeutic strategies, the efficacy of which for the treatment of coronavirus disease 2019 (COVID-19) was unknown at the time. Remdesivir (REM) was granted its first conditional marketing authorisation in the EU in June 2020. The European Medicines Agency (EMA) and local health authorities all across the EU have since strongly ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2021 - BMJ | European Journal of Hospital Pharmacy
Maria da Conceição Cunha, L. Pinheiro, João A. Zeferino, António Pais Antunes, Pedro Afonso,
The wastewater generated in urban areas is one of the main sources of water pollution, particularly in regions characterized with large population density and high urbanization degree. In this paper, we present an optimization model for regional wastewater systems planning. The model is aimed at helping to determine the best possible configuration (layout of sewer networks, location of treatment plants, etc.) for the wastewater system of a region taking economic, environmental, and technical criteria ...
Tópico(s): Urban Stormwater Management Solutions
2008 - American Society of Civil Engineers | Journal of Water Resources Planning and Management
I Dajti, José Ignacio Valenzuela, L Boccalatte, Nicolas A Gemelli, Dantwan Smith, Nagendra N. Dudi‐Venkata, Hidde M. Kroon, Tarik Sammour, Matthew M. Roberts, D Mitchell, K Lah, A Pearce, Dion Morton, Amanda Dawson, A Drane, Claire Sharpin, Ramesh Nataraja, Maurizio Pacilli, Daniel Cox, Vijayaragavan Muralidharan, Georgina Riddiough, Edmund Clarke, Wael Jamel, Kirby R. Qin, Peter Pockney, Daron Cope, N Egoroff, Natalie Lott, Sven Putnis, S De Robles, Zen Yang Ang, Martin Mitteregger, Stefan Uranitsch, Marjorie Stiegler, Gerald Seitinger, Felix Aigner, D B Lumenta, Sebastian P. Nischwitz, Erika Richtig, Mauro Pau, Petra Srekl-Filzmaier, Nicolas Eibinger, Birgit Michelitsch, Melanie Fediuk, A Papinutti, Geoffrey Seidel, Joseph Kahn, Tina Cohnert, Donna A. Messner, F. Ofner, J Presl, Márta Varga, Michael Weitzendorfer, K. Emmanuel, Alf-Dorian Binder, Marc Zimmermann, S Holawe, Emeka Nkenke, Christoph Grimm, M Kranawetter, Ashrarur Rahman Mitul, Nazmul Islam, Syed S. Karim, Niels Komen, Sven Putnis, S De Robles, Emily Ang, Herbert De Praetere, Tim Tollens, G Schols, C. Smets, Laura Haenen, Jorien Quintens, K Van Belle, Gabriëlle H. van Ramshorst, Piet Pattyn, Liesbeth Desender, Thomas Martens, Dirk Van de Putte, Philip Lerut, Aude Grimonprez, Marcus L.F. Janssen, G. De Smul, P. Wallaert, Jef Van den Eynde, Wouter Oosterlinck, Raf Van den Eynde, An Sermon, A. Boeckxstaens, Anne-Laure Cordonnier, Jeroen De Coster, Joris Jaekers, Constantinus Politis, Marc Miserez, Nicolas Duchateau, Charles de Gheldere, Nicolas Flamey, Piet Pattyn, A Christiano, Benedetta Guidi, A L Minussi, Sílvia Castro, Willy Okoba, F H R Maldonado, Paulo Oliveira, Tiago Antônio Baldasso, Luciano Marques dos Santos, Gustavo Mendonça Ataíde Gomes, Igor Lima Buarque, Laércio Pol Fachin, Tainá Santos Bezerra, Aldo Vieira Barros, A Silva, A L S Leite, Daniela Silvestre, C Carvalho Ferro, M S Araujo, L. M. Lopes, Pâmela dos Santos Bittencourt Damasceno, D H S Araujo, Gustavo Andreazza Laporte, M Salem, Marco Guimarães-Filho, Lucas Souto Nacif, Ronald Luiz Gomes Flumignan, Luís CU Nakano, Danielle Akemi Bergara Kuramoto, A L S Aidar, Mariana Raffo Pereda, R M Correia, Brena Costa Santos, Alzira Alves de Siqueira Carvalho, Jorge Eduardo de Amorim, Henrique Jorge Guedes Neto, Libnah Leal Areias, Álvaro Francisco Lopes de Sousa, Carolina Dutra Queiroz Flumignan, W G Lustre, Doris Hupfeld Moreno, Nathana Prado de Almeida Barros, José Carlos Costa Baptista‐Silva, Leandro Luongo de Matos, L P Kowaski, Marco Aurélio Vamondes Kulcsar, KS Nunes, Marcos F.S. Teixeira, Rafael Leite Nunes, Takeshi Ijichi, N. J. Kim, Ana Beatriz Pontes Marreiro, Bárbara Müller, Joseph Awada, Glauco Baiocchi, Luiz Paulo Kowalski, JG Vartanian, Fabiana B. Makdissi, Samuel Aguiar, Nuno Marques, Genival Barbosa de Carvalho, Tatiana Marques, Emne Ali Abdallah, Charles Edouard Zurstrassen, Jamie Gross, Stênio de Cássio Zéqui, Bruna Tirapelli Gonçalves, Sigrid de Sousa dos Santos, João Pedreira Duprat Neto, Felipe José Fernández Coimbra, Rafael De Cicco, Flávio Roberto Takeda, Ivan Cecconello, Ulysses Ribeiro, A Gatti, R Oliva, C Nardi, Mihail Slavchev, Boyko Atanasov, Nikolay Belev, Angela Dell, David L. Bigam, Khaled Dajani, S Al Riyami, Janet Martin, Davy Cheng, Hua Yang, A Fayad, François Martin Carrier, E. Amzallag, Joannie Desroches, Marie T. Ruel, Natasha Caminsky, Marylise Boutros, J Moon, E. G. C. Wong, Tsafrir Vanounou, Jonathan Pelletier, S Wong, Elie Girsowicz, J Bayne, Daniel I. Obrand, Heather L. Gill, Oren K. Steinmetz, Kenneth MacKenzie, Marie‐Amélie Lukaszewski, Ghader Jamjoum, Philippe Richebé, Olivier Verdonck, S Discepola, Nathalie Godin, M. Idrissi, Vincent Lecluyse, Geneviève Côté, Sebastian Demyttenaere, Richard Garfinkle, Marylise Boutros, A Kouyoumdjian, Marylise Boutros, Sinziana Dumitra, J Moon, E. G. C. Wong, Kosar Khwaja, Lan Luo, Marie‐Amélie Lukaszewski, Heather L. Gill, Gerald J. Berry, Adrienne Liberman, Elie Girsowicz, J Bayne, Daniel I. Obrand, Oren K. Steinmetz, Kenneth MacKenzie, Severin Schmid, Jonathan Spicer, Mehdi Farsi, Jad Abou‐Khalil, Étienne J. Couture, Seyede Momeneh Mohammadi, Hugo Tremblay, Nathalie Gagné, Anne Bergeron, Alexis F. Turgeon, O. Costerousse, David Bellemare, C. Babin, Catherine Blier, M L Wood, Amit Persad, Gary Groot, Hau Pham, Frédérick D’Aragon, Élaine Carbonneau, Maude Bouchard, Marie-Hélène Masse, F Pesant, Jennifer Héroux, Paul J. Karanicolas, Julie Hallet, A Nadler, Avery B. Nathens, M Ko, A Brar, Kelly Mayson, B Kidane, Sadeesh Srinathan, M Escudero, Janette T. Reyes, María Marta Modolo, P Ramirez Nieto, Rodrígo Sepúlveda, A Bolbarán, Andrés Molero‐Chamizo, Isaac Ruiz, Gabriel Reyes, Rafael Salas, Cristóbal Suazo, Rodrigo Muñoz, E Grasset, Martín Inzunza, Nicolás Besser, M J Irarrázaval, Cristián Jarry, Felipe Bellolio, C A Romero Manqui, M Ruiz Esquide, T. Fuentes, José Luis Campos, Carlos J. Pérez-Rivera, Payton Cabrera, Raúl Eduardo Pinilla Morales, Óscar Guevara, LJ Jimenez Ramirez, B G Velasquez Cuasquen, Damián Mora, A Bonilla, Sandra Diaz, E Manrique,
To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in surgical patients with SARS-CoV-2. We found that patient rather than operation factors were the best predictors and used these to create the COVIDsurg Mortality Score (https://covidsurgrisk.app). Our data demonstrates that it is safe to restart a wide ...
Oxford University Press
Vânia Pais, Pedro Silva, João Bessa, Hernâni Dias, Maria Helena Duarte, Fernando Cunha, Raúl Fangueiro,
Low-velocity impact can cause serious damage to the person or structure that is hit. The development of barriers that can absorb the energy of the impact and, therefore, protect the other side of the impact is the ideal solution for the pointed situation. Auxetic materials and shear thickening fluids are two types of technologies that have great capabilities to absorb high levels of energy when an impact happens. Accordingly, within this study, the combination of auxetic knits with shear thickening ...
Tópico(s): Advanced Materials and Mechanics
2022 - Multidisciplinary Digital Publishing Institute | Polymers
Ricardo Franco‐Duarte, Neža Čadež, Teresa Rito, João Drumonde‐Neves, Yazmid Reyes Domínguez, Célia Pais, Maria João Sousa, Pedro Soares,
Clavispora santaluciae was recently described as a novel non-Saccharomyces yeast species, isolated from grapes of Azores vineyards, a Portuguese archipelago with particular environmental conditions, and from Italian grapes infected with Drosophila suzukii. In the present work, the genome of five Clavispora santaluciae strains was sequenced, assembled, and annotated for the first time, using robust pipelines, and a combination of both long- and short-read sequencing platforms. Genome comparisons ...
Tópico(s): Plant Pathogens and Fungal Diseases
2022 - Multidisciplinary Digital Publishing Institute | Journal of Fungi
Diogo Pais, Diogo Casal, Luís Mascarenhas‐Lemos, Pedro C. Barata, B.J. Moxham, João Goyri-O’Neill,
Teaching time dedicated to anatomy education has been reduced at many medical schools around the world, including Nova Medical School in Lisbon, Portugal. In order to minimize the effects of this reduction, the authors introduced two optional, semester-long cadaveric dissection courses for the first two years of the medical school curriculum. These courses were named Regional Anatomy I (RAI) and Regional Anatomy II (RAII). In RAI, students focus on dissecting the thorax, abdomen, pelvis, and perineum. ...
Tópico(s): Innovations in Medical Education
2016 - Wiley | Anatomical Sciences Education
Joana Alves Ribeiro, F. J. G. Pinheiro, Maria Alexandra Pais, Rute Santos, João Cardoso, Pedro Baltazar‐Soares, Fernando A. Monteiro Santos,
Abstract New geomagnetically induced current (GIC) computations for mainland Portugal include the entire power network, with network parameters and topology provided by the transmission grid operator for all the high voltage lines (150, 220, and 400 kV). The first 3D conductivity model for the west region of the Iberian Peninsula, based on 31 broadband magnetotelluric soundings, is used in calculations, revealing the effect of different crustal domains in GIC distribution. Geomagnetic field variations ...
Tópico(s): Earthquake Detection and Analysis
2023 - American Geophysical Union | Space Weather
Pedro Almeida Vinagre, Antónia Juliana Pais-Costa, Rui Gaspar, Ángel Borja, João Carlos Marques, João M. Neto,
The compliance of macroalgal and macroinvertebrate assemblages to anthropogenic disturbance gradients (e.g., nutrient enrichment) was investigated at intertidal rocky shores. Macroalgae and macroinvertebrates presented parallel behavior, both showing shifts in the communities’ structural variation along the gradients, in which an higher number of opportunistic species (and higher abundances) were found in more stressful sites (close to the disturbance source), in contrast to less disturbed sites (far ...
Tópico(s): Isotope Analysis in Ecology
2015 - Elsevier BV | Ecological Indicators
Kisa Hyde Congo, Adriana Belo, João Carvalho, David Neves, Rui Guerreiro, J A Da Conceicao Pedro Pais, D Bras, M Carrington, B Picarra, Ana Rita Santos, José Aguiar,
Backgrund: New-onset atrial fibrillation complicating acute myocardial infarction represents an important challenge, with prognostic significance. Objective: To study the incidence, impact on therapy and mortality, and to identify predictors of development of new-onset atrial fibrillation during hospital stay for ST-segment elevation myocardial infarction. Methods: We studied all patients with ST-elevation myocardial infarction included consecutively, between 2010 and 2017, in a Portuguese national ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2019 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Pedro Almeida Vinagre, Antónia Juliana Pais-Costa, Stephen J. Hawkins, Ángel Borja, João Carlos Marques, João M. Neto,
The implementation of directives such as the European Water Framework Directive (WFD) and the Marine Strategy Framework Directive (MSFD) has promoted the development of several tools and methods for assessing the ecological health of marine ecosystems. Within the scope of the WFD and in terms of rocky shores, several multimetric tools were developed based on the macroalgae biological quality element (BQE), in addition to those based on macroinvertebrates. The WFD requires member states to assess each ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2016 - Elsevier BV | Ecological Indicators
Carla Pais-Vieira, Pedro Gaspar, Demétrio Matos, Leonor Palminha Alves, Bárbara Cruz, Maria João Azevedo, Miguel Gago, Tânia Poleri, André Perrotta, Miguel Pais-Vieira,
Brain-machine interfaces combining visual, auditory, and tactile feedback have been previously used to generate embodiment experiences during spinal cord injury (SCI) rehabilitation. It is not known if adding temperature to these modalities can result in discomfort with embodiment experiences. Here, comfort levels with the embodiment experiences were investigated in an intervention that required a chronic pain SCI patient to generate lower limb motor imagery commands in an immersive environment combining ...
Tópico(s): Muscle activation and electromyography studies
2022 - Frontiers Media | Frontiers in Human Neuroscience
Pedro Dinis, Jorge Dinis, Mário Miguel Mendes, Jacques Rey, João Pais,
The present study investigates the climatic influence on the geochemistry and mineralogy of the Lower Cretaceous succession of the Ericeira region (Lusitanian Basin, western Portugal). Palaeoclimatic conditions are inferred from a combination of weathering indices and independent palynological and palaeobotanical data. A composite weathering intensity index is computed from selected geochemical and mineralogical data. The concentrations of some elements (Co, Ni, Sc, Th, V, Y, Zn, Zr) indicate variable ...
Tópico(s): Geochemistry and Geologic Mapping
2015 - Elsevier BV | Comptes Rendus Géoscience
Pedro Almeida Vinagre, Antónia Juliana Pais-Costa, João Carlos Marques, João M. Neto,
Abstract The Water Framework Directive requires all Member States to achieve good ecological quality status for all waters (e.g., transitional waters). For that purpose, Member States must assess water bodies based on information on the Biological Quality Elements listed for each of them (e.g., benthic macroinvertebrates). However, the production of such a quality status classification (high, good, moderate, poor, bad) requires high reference conditions (associated with the absence of, or very low, ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2015 - Elsevier BV | Ecological Indicators
C. A. De Nieto Castro, João M. N. A. Fareleira, Pedro M. Matias, M. L. V. Ramires, Alberto A. C. C. Pais, A. J. C. Varandas,
Abstract Theoretical calculations of the second virial coefficients, self‐diffusion, viscosity and thermal conductivity of monatomic alkali metal vapours, lithium, sodium, potassium, cesium and rubidium are presented. The calculations have been carried out using reliable analytical two body interaction potential energy functions for the ground singlet 1 Σ + g and the excited triplet 3 Σ + g molecular states of the alkali dimers. The results are compared with previously calculated values. — The interpretation ...
Tópico(s): Chemical Thermodynamics and Molecular Structure
1990 - | Berichte der Bunsengesellschaft für physikalische Chemie
Pedro Almeida Vinagre, Helena Veríssimo, Antónia Juliana Pais-Costa, Stephen J. Hawkins, Ángel Borja, João Carlos Marques, João M. Neto,
The utility and concordance of application of taxonomic-based (diversity, richness and composition) and functional-based (biological traits analysis and functional diversity indices) metrics to distinguish anthropogenic disturbance or stress gradients (e.g., nutrient enrichment) on intertidal rocky shores were explored using macroinvertebrate communities. Metrics from both approaches showed similar trends in the variation of communities along the gradients, in which higher ecological health was found ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2016 - Elsevier BV | Ecological Indicators
Diogo Casal, Maria Helena Casimiro, L.M. Ferreira, João Paulo Leal, Gabriela Rodrigues, Raquel da Silva Lopes, Diogo Lino Moura, Luís G. Gonçalves, João Henrique G. Lago, Diogo Pais, Pedro M.P. Santos,
It has increasingly been recognized that electrical currents play a pivotal role in cell migration and tissue repair, in a process named "galvanotaxis". In this review, we summarize the current evidence supporting the potential benefits of electric stimulation (ES) in the physiology of peripheral nerve repair (PNR). Moreover, we discuss the potential of piezoelectric materials in this context. The use of these materials has deserved great attention, as the movement of the body or of the external environment ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2023 - Multidisciplinary Digital Publishing Institute | Biomedicines
José Brilha, César Andrade, Ana C. Azerêdo, Fernando Barriga, Mário Cachão, Helena Couto, Pedro P. Cunha, José Crispim, Pedro Dantas, Luís V. Duarte, Maria Conceição Freitas, Helena Granja, Maria Helena Henriques, Patrícia Alexandra Machado Henriques, Luís Lopes, José Madeira, João Xavier Matos, Fernando Noronha, João Pais, José Manuel Piçarra, M.M. Ramalho, Jorge M. R. S. Relvas, A. Ribeiro, Ana Santos, V.F. Santos, Pedro Terrinha,
J. Brilha, C. Andrade, A. Azerêdo, F.J.A.S. Barriga, M. Cachão, H. Couto, P.P. Cunha, J.A. Crispim, P. Dantas, L.V. Duarte, M.C. Freitas, H.M. Granja, M.H. Henriques, P. Henriques, L. Lopes, J. Madeira, J.M.X. Matos, F. Noronha, J. Pais, J. Piçarra, M.M. Ramalho, J.M.R.S. Relvas, A. Ribeiro, A. Santos, V.F. Santos, P. Terrinha. Episodes 2005;28:177-86. https://doi.org/10.18814/epiiugs/2005/v28i3/004
Tópico(s): earthquake and tectonic studies
2005 - International Union of Geological Sciences | Episodes
Rui Pedro Marques, Gonçalo S. Duarte, Carmelo Sterrantino, Helena Luna Pais, António Quintela, Ana Paula Martins, João Costa,
Uncertainty exists regarding the comparative effectiveness of triplet chemotherapy (FOLFOXIRI) as backbone first-line chemotherapy for metastatic colorectal cancer (mCRC). We conducted a systematic review and meta-analysis of randomized-controlled trials (RCTs) comparing triplet versus doublet chemotherapy (FOLFOX or FOLFIRI) as first-line therapy in mCRC. Methods and reporting followed PRISMA and SAMPL guidelines. Eight RCTs were included, comprising 1732 patients. In pooled analysis, FOLFOXIRI was ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2017 - Elsevier BV | Critical Reviews in Oncology/Hematology
J Bento-Rodrigues, F Judas, Jorge Pedrosa Rodrigues, João Oliveira, Pedro Simões, Francisco Manuel Demera Lucas, António Pais Lopes,
Necrotizing Fasciitis is a rapidly progressive, potentially fatal infection of superficial fasciae and subcutaneous tissue, usually resulting from an inciting trauma to the skin. Medical literature refers few cases of necrotizing fasciitis related to intra-articular infiltrations, that often lead to patients death. This report describes the clinical events on a 55 year-old diabetic patient who developed upper extremity Necrotizing Fasciitis, 18 days after shoulder mobilization and intra-articular ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2013 - Ordem dos Médicos | Acta Médica Portuguesa
Joana Simões, Ana Rita Ferreira, Pedro Martins Almeida, Frederico Trigueiros, Armando Braz, João R. Inácio, Fábio Medeiros, Sandra Bráz, António Pais de Lacerda,
Organizing pneumonia (OP) is a sub-acute process of pulmonary tissue repair secondary to lung injury, defined histopathologically by intra-alveolar buds of granulation tissue within the lumen of distal pulmonary airspaces. It can be either cryptogenic or secondary (SOP) to different clinical conditions, namely infections. Despite being nonspecific, its diagnosis can be made by the association of clinical and imaging criteria. We report two cases of OP associated to SARS-CoV-2 pneumonia, admitted at ...
Tópico(s): COVID-19 diagnosis using AI
2021 - Elsevier BV | Respiratory Medicine Case Reports
Manuel Vieira, Emília Poças, João Pais, D. I. Pereira,
This paper deals with the systematic and botanical description of the microfloral elements from the Pliocene S. Pedro da Torre section (NW Portugal) and the description of the palaeoenvironment and palaeoclimate, for use as a correlation attempt with other Pliocene deposits. The S. Pedro da Torre section represents one of the main sites which may help us to understand the vegetation and the paleoenvironment of the Pliocene north-western Iberian Peninsula. Nearly 70 different taxa were indentified ( ...
Tópico(s): Plant Ecology and Taxonomy Studies
2011 - Muséum national d'histoire naturelle | Geodiversitas
Carolina Peixoto, Marta B. Lopes, Marta Martins, Sandra Casimiro, Daniel Sobral, Ana Rita Grosso, Catarina Abreu, Daniela Macedo, Ana Lúcia Costa, Helena Luna Pais, Cecília Alvim, André Mansinho, Pedro Filipe, Pedro Marques da Costa, Afonso Fernandes, Paula Borralho, Cristina Ferreira, João Malaquias, António Quintela, Shannon Kaplan, Mahdi Golkaram, Michael Salmans, Nafeesa Khan, Raakhee Vijayaraghavan, Shile Zhang, Traci Pawlowski, Jim Godsey, Alex So, Li Liu, Luís Costa, Susana Vinga,
Colorectal cancer (CRC) is the third most common cancer and the second most deathly worldwide. It is a very heterogeneous disease that can develop via distinct pathways where metastasis is the primary cause of death. Therefore, it is crucial to understand the molecular mechanisms underlying metastasis. RNA-sequencing is an essential tool used for studying the transcriptional landscape. However, the high-dimensionality of gene expression data makes selecting novel metastatic biomarkers problematic. ...
Tópico(s): RNA Research and Splicing
2023 - BioMed Central | BMC Bioinformatics
José Pedro Pais, Maria Caçador, Teresa Mourato, João Paço,
Nasopharyngeal and otitis media tuberculosis are rare extrapulmonary manifestations of Mycobacterium tuberculosis infection. We present a case of a middle-aged woman with manifestations of both conditions along with a description of the anatomical and temporal evolution of the disease. This case also highlights the difficulty of diagnosis and management of this condition, requiring a multidisciplinary approach. Extrapulmonary tuberculosis must be considered in the differential diagnosis of multiple ...
Tópico(s): Diagnosis and treatment of tuberculosis
2022 - BMJ | BMJ Case Reports
Produção Nacional
Revisado por pares
João Pedro Ferreira, Tiago Taveira‐Gomes, Mariana Canelas‐Pais, Phillip Phan, Filipa Bernardo, Karolina Andersson Sundell, Mário Almeida, Hugo Martinho, Cristina Gavina,
Heart failure (HF) is a leading cause of hospitalization worldwide. An early HF diagnosis is key to reducing hospitalizations. We used electronic health records (EHRs) to characterize HF pathways at the primary care physician (PCP) level prior to a first HF hospitalization (hHF). This study aimed to identify missed opportunities for HF diagnosis and management at the PCP level before a first hHF.This cohort study used EHRs of a large health care organization in Portugal. Patients with incident hHF between ...
Tópico(s): Cardiac pacing and defibrillation studies
2023 - Wiley | ESC Heart Failure
Antónia Juliana Pais-Costa, Marta I. Sánchez, Mark A. Taggart, Andy J. Green, Francisco Hortas, Pedro Almeida Vinagre, João Carlos Marques, Mónica Martínez-Haro,
Hypersaline ecosystems are under increasing threat due to anthropogenic pressures such as environmental pollution and biological invasions. Here we address the ecotoxicological implications of the Artemia franciscana (Crustacea) invasion in saltpans of southern Spain. This North American species is causing the extinction of native Artemia populations in many parts of the globe. The bioaccumulation of trace elements (As, Cd, Cu, Co, Cr, Mn, Ni, Pb and Zn) in native populations (A. parthenogenetica) ...
Tópico(s): Mercury impact and mitigation studies
2021 - Elsevier BV | The Science of The Total Environment
Teresa Pinto-Pais, Sónia Fernandes, Luísa Proença, Pedro Roquete, Tiago Pereira, João Carvalho, José Carlos Soares de Fraga,
A 71-year-old woman was admitted due to recurrent lower gastrointestinal bleeding. She had undergone segmental colonic resection and adjuvant chemotherapy for colon adenocarcinoma 10 years earlier, without recurrence on follow-up. She reported experiencing several self-limited episodes of hematochezia over the past 6 months, without other symptoms.
Tópico(s): Gastrointestinal disorders and treatments
2014 - Thieme Medical Publishers (Germany) | Endoscopy
Luísa Pedro, José Luís Pais Ribeiro, João Páscoa Pinheiro,
Abstract Introduction: Multiple sclerosis (MS) is a chronic disease of the central nervous system that mainly affects young adults, promoting a great impact on functionality. Fatigue is a very common symptom, associated with multiple impairments in sensitivity, muscle activity, neuromotor control, balance, cognition and problem-solving ability. MS leads to strong functional restrictions, particularly in the context of daily living activities, as well as in patient participation. Objective: To understand ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2021 - PONTIFÍCIA UNIVERSIDADE CATÓLICA DO PARANÁ | Fisioterapia em Movimento