Teresa Cardoso, Filomena Pestana, João Aragão e Pina,
1 Universidade Aberta (PORTUGAL)2 LE@D, Laboratório de Educação a Distância e Elearning (PORTUGAL)3 ISCTE-IUL (PORTUGAL)
Tópico(s): Online Learning and Analytics
2019 - International Academy of Technology, Education and Development | EDULEARN proceedings
Ana Pestana, João Vinagre, Manuel Sobrinho‐Simões, Paula Soares,
Evasion of replicative senescence and proliferation without restriction, sometimes designated as immortalisation, is one of the hallmarks of cancer that may be attained through reactivation of telomerase in somatic cells. In contrast to most normal cells in which there is lack of telomerase activity, upregulation of TERT transcription/activity is detected in 80–90% of malignant tumours. In several types of cancer, there is a relationship between the presence of TERT promoter mutations, TERT mRNA ...
Tópico(s): Nuclear Structure and Function
2017 - Bioscientifica | Journal of Molecular Endocrinology
Produção Nacional
Revisado por pares
... 2015).https://doi.org/10.2139/ssrn.2614179Carlos Pestana Barros, João Ricardo Faria, Ari Francisco de Araujo BRAZILIAN LAND ...
Tópico(s): Crime Patterns and Interventions
2004 - University of Chicago Press | Economic Development and Cultural Change
... org/10.1016/j.ecolecon.2014.08.007Carlos Pestana Barros, João Ricardo Faria, Ari Francisco de Araujo BRAZILIAN LAND ...
Tópico(s): Innovation and Socioeconomic Development
2003 - University of Chicago Press | Economic Development and Cultural Change
Ramóan Lóapez, Alberto Valdés,
... 582.https://doi.org/10.1093/erae/jbt032Carlos Pestana Barros, João Ricardo Faria, Ari Francisco de Araujo BRAZILIAN LAND ...
Tópico(s): Agricultural risk and resilience
2000 - University of Chicago Press | Economic Development and Cultural Change
Mark L. Mitchell, Michael T. Maloney,
... 1350.https://doi.org/10.1093/ajae/aaq065Carlos Pestana Barros, Joao Ricardo Faria, Luis Alberiko Gil-Alana Persistence of ...
Tópico(s): Law, Economics, and Judicial Systems
1989 - University of Chicago Press | The Journal of Law and Economics
Produção Nacional
Revisado por pares
Goia de Mattos Lyra, José Marcos de Castro Nunes, Edilene Maria dos Santos Pestana, João Carlos Gama de Matos, Taiara Aguiar Caires, Priscila Barreto de Jesus, Emmanuelle da S. Costa, Mariana C. Oliveira,
The Gracilariaceae comprises 242 mainly tropical species, including some with significant economic value for the food and pharmaceutical industry. Accurate taxonomy is crucial for the selection of species for cultivation. However, species identification is still challenging taxonomists. Nineteen species of Gracilariaceae have so far been referred to the Brazilian coast. We describe this diversity across approximately 32 degrees of latitude, using mitochondrial (COI-5P) and plastid (UPA and rbcL) markers ...
Tópico(s): Coral and Marine Ecosystems Studies
2021 - Q15088586 | Phytotaxa
Carolina F. F. A. Costa, Benedita Sampaio‐Maia, Ricardo Araújo, Diana S. Nascimento, Joana Ferreira‐Gomes, Manuel Pestana, Maria João Azevedo, Inês S. Alencastre,
Fibrosis is a pathological process associated with most chronic inflammatory diseases. It is defined by an excessive deposition of extracellular matrix proteins and can affect nearly every tissue and organ system in the body. Fibroproliferative diseases, such as intestinal fibrosis, liver cirrhosis, progressive kidney disease and cardiovascular disease, often lead to severe organ damage and are a leading cause of morbidity and mortality worldwide, for which there are currently no effective therapies ...
Tópico(s): Liver Disease Diagnosis and Treatment
2022 - Multidisciplinary Digital Publishing Institute | Nutrients
Sofia Magina, Janete Quelhas‐Santos, Andreia S.P.S. Coroas, José Gerardo Oliveira, Paula Serrão, Patrício Soares‐da‐Silva, Carlos Resende, Manuel Pestana,
... on: Oxford Academic Google Scholar M. Pestana M. Pestana Nephrology, Hospital S. João M. Pestana. E‐mail: mvasconcelos@hsjoao.min‐saude.pt Search ...
Tópico(s): Lysosomal Storage Disorders Research
2005 - Oxford University Press | British Journal of Dermatology
Carlos Pestana Barros, Bruno Damásio, Jo�ão Ricardo Faria,
... for more papers by this authorJoão Ricardo Faria, João Ricardo FariaCarlos Pestana Barros, ISEG School of Economics and Management, UECE, ... for more papers by this authorJoão Ricardo Faria, João Ricardo FariaCarlos Pestana Barros, ISEG School of Economics and Management, UECE, Technical University of Lisbon, Portugal; e-mail: [email protected]. Bruno Damásio, ISEG-School of Economics and Management, and CEMAPRE, Technical University of Lisbon, Portugal; e-mail: [email protected]. João Ricardo Faria, MPA Program, University of Texas at ...
Tópico(s): Global Financial Crisis and Policies
2014 - Wiley | African Development Review
Produção Nacional
Revisado por pares
Neide da Silva Knihs, Juliana dos Santos, Sibele Maria Schuantes Paim, Aline Lima Pestana Magalhães, João Luís Erbs Pessoa, Saulo Fábio Ramos, Janine Schirmer, Ivonei Bittencourt, Helen Cristine Albuquerque Bezerra, Maria Lígia dos Reis Bellaguarda, Elza Lima da Silva,
To analyze evidence capable of supporting best practices available in the literature to create dialogues about organ and tissue donation with parents of deceased children and adolescents. An integrative literature review performed using Scopus, Cochrane, PsycINFO, PubMed/MEDLINE, Web of Science database, and SciELo electronic libraries from November of 2013 to November of 2018, using keyword syntax for each database. The categories were developed using the Alicante model. A total of 745 articles ...
Tópico(s): Palliative Care and End-of-Life Issues
2020 - Elsevier BV | Transplantation Proceedings
Vítor Borges, Mariana Duque, João Vieira Martins, Paula Vasconcelos, Rita Ferreira, Daniel Sobral, Ana Pelerito, Isabel Lopes de Carvalho, Maria Sofia Núncio, Maria José Borrego, Cornelius Roemer, Richard A. Neher, Megan O’Driscoll, Raquel Rocha, Sílvia Lopo, Raquel Neves, Paula Palminha, Luís Coelho, Alexandra Nunes, Joana Isidro, Miguel Pinto, João Santos, Verónica Mixão, Daniela Santos, Sílvia Duarte, Luı́s Vieira, Fátima Martins, Jorge Machado, Vítor Cabral Veríssimo, Berta Grau-Pujol, André Peralta‐Santos, José Neves, Margarida Caldeira, Mafalda Pestana, Cândida Fernandes, João Caria, Raquel Pinto, Diana Póvoas, Fernando Maltêz, Ana Isabel Sá, Mafalda Brito Salvador, Eugénio Teófilo, Miguel Rocha, Virgínia Moneti, Luís Duque, Francisco Ferreira e Silva, Teresa Baptista, Joana Vasconcelos, Sara Casanova, Kamal Mansinho, João Vaz Alves, João M. P. Alves, António Silva, Miguel Alpalhão, Claúdia Brazão, Diogo de Sousa, Paulo Filipe, Patrícia Pacheco, Francesca Peruzzu, Rita Patrocínio de Jesus, Luís Ferreira, Josefina Mendez, Sofia Jordão, Frederico Duarte, Maria João Gonçalves, Eduarda Pena, Cláudio Silva, André Rodrigues Guimarães, Margarida Tavares, Graça Freitas, Rita Cordeiro, João Paulo Gomes,
Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that ...
Tópico(s): Herpesvirus Infections and Treatments
2023 - Nature Portfolio | Nature Medicine
Pedro R. Miranda, Daniel Pestana, João D. Lopes, Rui Policarpo Duarte, Mário Véstias, Horácio C. Neto, José T. de Sousa,
Object detection is an important task for many applications, like transportation, security, and medical applications. Many of these applications are needed on edge devices to make local decisions. Therefore, it is necessary to provide low-cost, fast solutions for object detection. This work proposes a configurable hardware core on a field-programmable gate array (FPGA) for object detection. The configurability of the core allows its deployment on target devices with diverse hardware resources. The ...
Tópico(s): Advanced Image and Video Retrieval Techniques
2021 - Multidisciplinary Digital Publishing Institute | Future Internet
Maria João Nabais Sá, Susana Sampaio, Anne Andrade Matiazi de Oliveira, Susana P. Alves, Carla Pinto Moura, Sérgio Silva, R. Castro, José Augusto Dias Araújo, Márcia Rodrigues, F. Neves, J. Seabra, Carlos Soares, Marian Gaşpar, Isabel Tavares, L. Freitas, Tânia Sousa, António Castro Henriques, Fábio Trindade Maranhão Costa, Elsa Morgado, F.T. Sousa, José Pedro Sousa, Adília Costa, R. Filipe, J. Garrido, J. Montalban, P Ponce, Rui Alves, Bernardo Faria, Maria Fernanda Carvalho de Camargo, Manuel Pestana, Filipa Carvalho, João Paulo Oliveira,
Alport syndrome (AS) is caused by pathogenic mutations in the genes encoding α3, α4 or α5 chains of collagen IV (COL4A3/COL4A4/COL4A5), resulting in hematuria, chronic renal failure (CRF), sensorineural hearing loss (SNHL) and ocular abnormalities. Mutations in the X-linked COL4A5 gene have been identified in 85% of the families (XLAS). In this study, 22 of 60 probands (37%) of unrelated Portuguese families, with clinical diagnosis of AS and no evidence of autosomal inheritance, had pathogenic COL4A5 ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2014 - Wiley | Clinical Genetics
M. S. Gião, Diogo Pestana, Ana Faria, João Tiago Guimarães, Manuela Pintado, Conceição Calhau, Isabella Evelyn Prado de Azevedo, F. Xavier Malcata,
Aqueous extracts of a few medicinal plants traditionally used in Portugal have been assayed for their effects upon hepatic oxidative stress in mice. Previous in vitro studies had allowed characterization of agrimony, sage, savory, and raspberry in terms of overall antioxidant capacity and phenolic content. In the present study, the antioxidant effect and safety of these four plants were evaluated in vivo. For this purpose, mice ingested extracts in aqueous form (or water, used as the control) for ...
Tópico(s): Essential Oils and Antimicrobial Activity
2010 - Mary Ann Liebert, Inc. | Journal of Medicinal Food
Produção Nacional
Revisado por pares
Samuel C. Pestana, João Machado, Rafael Pinto, Bernardo Dias Ribeiro, Isabel M. Marrucho,
Aiming at providing a new solution for processing and recycling PET, the full solubilization of PET from water bottles in natural eutectic solvents was achieved as well as its full recovery, retaining PET properties and recycling the eutectic solvent.
Tópico(s): Polymer Science and PVC
2021 - Royal Society of Chemistry | Green Chemistry
Ana Rita Santos, Miguel Raimundo, Dalila Alves, Marta Lopes, Sérgio Pestana, João Figueira, José Cunha‐Vaz, Rufino Silva,
To evaluate Microperimetry (MP) and multifocal electroretinogram (mfERG) as whole-macula functional markers of treatment response in naive diabetic macular oedema (DMO) patients undergoing ranibizumab treatment.An exploratory sub-analysis of a prospective study (NCT01947881-CHARTRES). Patients received three monthly ranibizumab injections (loading dose) followed by pro re nata (PRN) regimen during 1 year. At baseline, during and after treatment (Months 0, 3, 6 and 12), subjects were tested using BCVA, ...
Tópico(s): Retinal Development and Disorders
2020 - Springer Nature | Eye
Peter Wänke, Carlos Pestana Barros, Nkanga Pedro João Macanda,
Abstract This paper presents an efficiency assessment of the A ngolan banks using Technique for Order Preference by Similarity to the Ideal Solution ( TOPSIS ). TOPSIS is a multi‐criteria decision‐making technique similar to data envelopment analysis, which ranks a finite set of units based on the minimisation of distance from an ideal point and the maximisation of distance from an anti‐ideal point. In this research, TOPSIS is used first in a two‐stage approach to assess the relative efficiency of A ...
Tópico(s): Multi-Criteria Decision Making
2015 - Wiley | South African Journal of Economics
Daniel Pestana, Pedro R. Miranda, João D. Lopes, Rui Policarpo Duarte, Mário Véstias, Horácio C. Neto, José T. de Sousa,
Object detection and classification is an essential task of computer vision. A very efficient algorithm for detection and classification is YOLO (You Look Only Once). We consider hardware architectures to run YOLO in real-time on embedded platforms. Designing a new dedicated accelerator for each new version of YOLO is not feasible given the fast delivery of new versions. This work's primary goal is to design a configurable and scalable core for creating specific object detection and classification ...
Tópico(s): Advanced Image and Video Retrieval Techniques
2021 - Institute of Electrical and Electronics Engineers | IEEE Access
Giulia Cesarini, Francesca Coppola, Diana Campos, Iole Venditti, Chiara Battocchio, Andrea Di Giulio, Maurizio Muzzi, João L.T. Pestana, Massimiliano Scalici,
The concentration of nanoplastics (NPs) is expected to increase in aquatic environments thus potentially threatening freshwater organisms through interactions with plastic particles that variously float, circulate in the water column or sink into the benthos. Studies into the mechanisms of any NP effects are still scarce, particularly with respect to the regenerative ability of biota for which there is no recognised model organism. The present study therefore aimed to investigate behavioural and ...
Tópico(s): Nanoparticles: synthesis and applications
2023 - Elsevier BV | Environmental Pollution
Carlos J.M. Silva, Sónia Beleza, Diana Campos, Amadeu M.V.M. Soares, Ana L. Patrício Silva, João L.T. Pestana, Carlos Gravato,
Tópico(s): Marine Biology and Environmental Chemistry
2021 - Elsevier BV | Journal of Hazardous Materials
Carlos J.M. Silva, Ana L. Machado, Diana Campos, Andreia C. M. Rodrigues, Ana L. Patrício Silva, Amadeu M.V.M. Soares, João L.T. Pestana,
The high levels of microplastics (MPs) found in freshwaters, particularly in riverine sediments, may impose a threat to the macroinvertebrate communities with possible consequences at ecosystem-level. The present study aimed to assess the effects of a mixture of different sizes of polyethylene microplastics (PE-MPs) on the composition and structure of macroinvertebrate communities and key-functions, such as primary production and leaf litter decomposition. MPs were mixed in the sediment at three different ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2021 - Elsevier BV | The Science of The Total Environment
Ana‐Belén Muñiz‐González, Carlos J.M. Silva, Ana L. Patrício Silva, Diana Campos, João L.T. Pestana, José‐Luis Martínez‐Guitarte,
Freshwater riverbeds are a major repository of microplastics (MPs) from inland activities. Benthic macroinvertebrates that live in close contact with sediments seem to ingest a considerable amount of such plastic particles. The effects of MPs on life-history traits are relatively well-known, but the suborganismal mechanisms underlying such effects remain unclear. This study addressed the potential effects of low-density polyethylene (LDPE) MPs on Chironomus riparius larvae at cellular and molecular ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2021 - Elsevier BV | The Science of The Total Environment
Fátima C.P. Simão, Carlos Gravato, Ana L. Machado, Amadeu M.V.M. Soares, João L.T. Pestana,
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants of aquatic ecosystems. Because they are persistent, there is great potential for chronic toxicity to aquatic species, and the evaluation of reproductive effects is fundamental. In this context, planarians are interesting experimental animals, since they can be sensitive to environmental pollutants, and a wide range of reproductive-related endpoints can be assessed. In this work we evaluated fecundity (number of cocoons), fertility (number ...
Tópico(s): Marine Biology and Environmental Chemistry
2020 - Elsevier BV | Chemosphere
Carlos J.M. Silva, Ana L. Patrício Silva, Diana Campos, Amadeu M.V.M. Soares, João L.T. Pestana, Carlos Gravato,
Freshwater sediments are a repository of microplastics (MPs) resulting from inland anthropogenic activities. Benthic invertebrates, particularly endobenthic sediment–ingesting species such as the annelid Lumbriculus variegatus (blackworm), are commonly found in contaminated sediments where they likely find and ingest MPs. In the present study, L. variegatus was exposed to concentrations between 0.51 and 20 g kg−1 dry sediment of four size-classes of irregularly-shaped polyethylene MPs (PE-MPs; size- ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2020 - Elsevier BV | Ecotoxicology and Environmental Safety
Produção Nacional
Revisado por pares
Aline Silvestre Pereira Dornelas, Renato Almeida Sarmento, Grasiele Soares Cavallini, Rone da Silva Barbosa, Mayane Marques Vieira, Althiéris de Souza Saraiva, Maria D. Bordalo, Amadeu M.V.M. Soares, João L.T. Pestana,
Tópico(s): Subterranean biodiversity and taxonomy
2020 - Springer Science+Business Media | Environmental Science and Pollution Research
Fátima C.P. Simão, Carlos Gravato, Ana L. Machado, Amadeu M.V.M. Soares, João L.T. Pestana,
Freshwater planarians have been gaining relevance as experimental animals for numerous research areas given their interesting features, such as high regeneration potential, shared features with the vertebrates' nervous system or the range of endpoints that can be easily evaluated in response to contaminants. Ecotoxicological research using these animals has been steadily increasing in the past decades, as planarians' potentialities for this research area are being recognized. In this work, we used ...
Tópico(s): Marine Ecology and Invasive Species
2020 - Elsevier BV | Environmental Pollution
Carlos J.M. Silva, Ana L. Patrício Silva, Diana Campos, Ana L. Machado, João L.T. Pestana, Carlos Gravato,
Riverine sediments are major sinks of microplastics from inland anthropogenic activities, imposing a threat to freshwater benthic invertebrates. This study investigated the ingestion of three size-classes (SC) of irregularly shaped polyethylene microplastics (PE-MPs; SC I: 32−63 μm; II: 63−250 μm; III: 125−500 μm) after 48 h by dipteran larvae (detritivore/collector) Chironomus riparius, and the consequent effects on neurotransmission, energy allocation and oxidative stress. The tested PE-MPs concentrations ( ...
Tópico(s): Marine Biology and Environmental Chemistry
2020 - Elsevier BV | Journal of Hazardous Materials
Produção Nacional
Revisado por pares
Ana Moráis López, Renato Almeida Sarmento, Althiéris de Souza Saraiva, Renata Ramos Pereira, Amadeu M.V.M. Soares, João L.T. Pestana,
The demand of glyphosate-based herbicides including Roundup® is rising in the tropics due to increase occurence of glyphosate-resistant weeds that require higher herbicide application rates but also because of their use associated with genetically engineered, glyphosate-tolerant crops. Consequently, there is now an excessive use of glyphosate in agricultural areas with potential adverse effects also for the surrounding aquatic environments. This study aimed to determine the sensitivity of the freshwater ...
Tópico(s): Microplastics and Plastic Pollution
2019 - Elsevier BV | The Science of The Total Environment
Maria D. Bordalo, Carlos Gravato, Sandra Beleza, Diana Campos, Isabel Lopes, João L.T. Pestana,
Despite being considered environmentally safe, a deeper environmental risk assessment is needed for microbial insecticides; special attention should be devoted to their sublethal toxicity to non-target species. This study evaluated effects of VectoBac® 12AS - VB (based on the bacterium Bacillus thurigiensis var. israelensis) and Naturalis®-L - NL (based on the fungus Beauveria bassiana) on the aquatic insect Chironomus riparius life-history and biochemical responses. Acute tests estimated a 48 h-LC50 ( ...
Tópico(s): Insect Pest Control Strategies
2019 - Elsevier BV | The Science of The Total Environment