João Vasco Santos, João Pereira, Roberto Magalhães Pinto, Pedro Castro, Elsa Azevedo, Alberto Freitas,
Atrial fibrillation (AF) is a major risk factor for ischemic stroke (IS). Patients with AF may undergo preventive therapy. Although the AF impact in the clinical burden of IS has been studied, information is lacking in Southern Europe and there are no studies about the impact in potential years of life lost. Moreover, no nationwide or long-term study analyzed the economic burden of IS stratified by AF.To study the impact of AF in the clinical and economic burden of IS.We conducted a retrospective ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2017 - Elsevier BV | Value in Health
André Ramalho, Pedro Castro, Manuel Gonçalves‐Pinho, Juliana Silveira Teixeira, João Vasco Santos, João Viana, Mariana Lobo, Paulo Santos, Alberto Freitas,
Nowadays, evaluating the quality of health services, especially in primary health care (PHC), is increasingly important. In a historical perspective, the Department of Health (United Kingdom) developed and proposed a range of indicators in 1998, and lately several health, social and political organizations have defined and implemented different sets of PHC quality indicators. Some systematic reviews in PHC quality indicators are reported but only in specific contexts and conditions. The aim of this ...
Tópico(s): Healthcare Policy and Management
2019 - Public Library of Science | PLoS ONE
João Vasco Santos, João Viana, Carla Pinto, Júlio Souza, Fernando Lopes, Alberto Freitas, Sílvia Lopes,
The aims of this study were to assess All-Patient Refined Diagnosis-Related Groups' (APR-DRG) Severity of Illness (SOI) and Risk of Mortality (ROM) as predictors of in-hospital mortality, comparing with Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index (ECI) scores. We performed a retrospective observational study using mainland Portuguese public hospitalizations of adult patients from 2011 to 2016. Model discrimination (C-statistic/ area under the curve) and goodness-of-fit (R-squared) ...
Tópico(s): Machine Learning in Healthcare
2022 - Springer Science+Business Media | Journal of Medical Systems
Joel Vasco, João M. Maia, A. S. Pouzada,
Microinjection has proven to be one of the most efficient replication methods for microcomponents and microsystems in various domains of microengineering. The use of available commercial microinjection equipment to evaluate the polymeric flow in microchannels would surely contribute to enhancing knowledge on polymeric flow at the microscale under industrial conditions. This approach is appropriate since rheological phenomena such as wall slip, surface tension, melt pressure drop and polymer flow ...
Tópico(s): Nanofabrication and Lithography Techniques
2009 - IOP Publishing | Journal of Micromechanics and Microengineering
Bruno Faustino, António Branco Vasco, João Delgado, António Farinha‐Fernandes, José C. Guerreiro,
Early maladaptive schemas (EMS), as lifelong psychological structures, tend to be associated with psychopathological symptomatology. Previous research has suggested that schemas act as psychological vulnerabilities to stressful life situations, such as the present worldwide COVID-19 pandemic. In this context, anxiety and psychological distress have been documented as two of the main psychological symptoms associated with the COVID-19 pandemic. However, the associations between specific EMS and COVID- ...
Tópico(s): COVID-19 and Mental Health
2022 - Wiley | Clinical Psychology & Psychotherapy
Ana da Rosa Soares, Tânia Martins‐Marques, Teresa Ribeiro‐Rodrigues, João Vasco Ferreira, Steve Catarino, Maria João Pinho, Mónica Zuzarte, Sandra I. Anjo, Bruno Manadas, Joost P. G. Sluijter, Paulo Pereira, Henrique Girão,
Abstract Intercellular communication is vital to ensure tissue and organism homeostasis and can occur directly, between neighbour cells via gap junctions (GJ), or indirectly, at longer distances, through extracellular vesicles, including exosomes. Exosomes, as intercellular carriers of messenger molecules, mediate the transfer of biological information between donor and acceptor cells. Although the biological effects of exosomes in target cells have been intensively studied, the mechanisms that govern ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2015 - Nature Portfolio | Scientific Reports
Ana da Rosa Soares, Tânia Martins‐Marques, Teresa Ribeiro‐Rodrigues, Joao Vasco Ferreira, Steve Catarino, Maria João Pinho, Mónica Zuzarte, Sandra I. Anjo, Bruno Manadas, Joost P. G. Sluijter, Paulo Pereira, Henrique Girão,
Intercellular communication is vital to ensure tissue and organism homeostasis and can occur directly, between neighbour cells via gap junctions (GJ), or indirectly, at longer distances, through extracellular vesicles, including exosomes. Exosomes, as intercellular carriers of messenger molecules, mediate the transfer of biological information between donor and acceptor cells. Although the biological effects of exosomes in target cells have been intensively studied, the mechanisms that govern exosomal ...
Tópico(s): Connexins and lens biology
2015 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Marco Antônio Catussi Paschoalotto, Eduardo Costa, Sara Valente de Almeida, Joana Cima, Joana Gomes da Costa, João Vasco Santos, Pedro Pita Barros, Claúdia Souza Passador, João Luiz Passador,
To investigate how sociodemographic conditions, political factors, organizational confidence, and non-pharmaceutical interventions compliance affect the COVID-19 vaccine hesitancy in Brazil.Data collection took place between November 25th, 2020 and January 11th, 2021 using a nationwide online survey. Subsequently, the researches performed a descriptive analysis on the main variables and used logistic regression models to investigate the factors associated with COVID-19 vaccine hesitancy.Less concern ...
Tópico(s): Misinformation and Its Impacts
2021 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
João Vasco Santos, Júlio Souza, José Valente, Alonso Vera, André Ramalho, João Viana, Walter Ricciardi, Alberto Freitas,
The Global Burden of Disease study has generated a wealth of data on death and disability in Europe. At a time of change for the European Union and European Region of WHO, with a new Health Commissioner and Regional Director, respectively, a review of health trends can contribute to identify outstanding needs and gaps. This paper reports a summary of the burden of disease in the European Union (EU) in 2017 (compared with 2007).For the whole EU and each country, mortality by causes of death, disability- ...
Tópico(s): Global Public Health Policies and Epidemiology
2019 - Oxford University Press | European Journal of Public Health
Filipe Veloso Gomes, João Oliveira, Mariana Tomé Correia, Nuno Vasco Costa, João Abrantes, Daniel Torres, Pedro A. B. Pereira, Ana Isabel Ferreira, José Hugo Mendes Luz, Erik Spaepen, Tiago Bilhim, Élia Coimbra,
To evaluate the efficacy and safety of transarterial chemoembolization with polyethylene glycol (PEG) drug-eluting embolic agents in the treatment of hepatocellular carcinoma (HCC).A single-center retrospective study of 302 patients (258 men; 85.4%) with HCC treated during a 20-month period was conducted. The mean patient age was 66 years ± 10; 142 (47%) had Barcelona Clinic Liver Cancer stage A disease and 134 had (44.4%) stage B disease; 174 (57.6%) had a single HCC tumor, 65 (21.5%) had 2, and 62 (20.9%) ...
Tópico(s): Renal cell carcinoma treatment
2018 - Elsevier BV | Journal of Vascular and Interventional Radiology
Vasco Manquinho, João Marques‐Silva, Jordi Planes,
The Pseudo-Boolean Optimization (PBO) and Maximum Satisfiability (MaxSAT) problems are natural optimization extensions of Boolean Satisfiability (SAT). In the recent past, different algorithms have been proposed for PBO and for MaxSAT, despite the existence of straightforward mappings from PBO to MaxSAT, and vice-versa. This papers proposes Weighted Boolean Optimization (WBO), a new unified framework that aggregates and extends PBO and MaxSAT. In addition, the paper proposes a new unsatisfiability-based ...
Tópico(s): Bayesian Modeling and Causal Inference
2009 - Springer Science+Business Media | Lecture notes in computer science
... 8136-3_32-2Ken E. Giller, Thomas Delaune, João Vasco Silva, Katrien Descheemaeker, Gerrie van de Ven, Antonius ...
Tópico(s): Agriculture, Land Use, Rural Development
1992 - University of Chicago Press | Economic Development and Cultural Change
Vasco Manquinho, João Marques‐Silva,
Covering problems are widely used as a modeling tool in electronic design automation. Recent years have seen dramatic improvements in algorithms for the unate/binate covering problem (UCP/BCP). Despite these improvements, BCP is a well-known computationally hard problem with many existing real-world instances that currently are hard or even impossible to solve. In this paper we apply search pruning techniques from the Boolean satisfiability domain to branch-and-bound algorithms for BCP. Furthermore, ...
Tópico(s): Manufacturing Process and Optimization
2002 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Vasco Branco, João Canário, Arne Holmgren, Cristina Carvalho,
Tópico(s): Heavy Metal Exposure and Toxicity
2010 - Elsevier BV | Toxicology and Applied Pharmacology
Vasco Branco, João Canário, Jun Lu, Arne Holmgren, Cristina Carvalho,
Mercury compounds exert toxic effects via interaction with many vital enzymes involved in antioxidant regulation, such as selenoenzymes thioredoxin reductase (TrxR) and glutathione peroxidase (GPx). Selenium supplementation can reactivate the mercury-inhibited TrxR and recover the cell viability in vitro. To gain an insight on how selenium supplementation affects mercury toxicity in vertebrates, we investigated the effects of selenium on the mercury accumulation and TrxR and GPx activities in a fish ...
Tópico(s): Selenium in Biological Systems
2011 - Elsevier BV | Free Radical Biology and Medicine
Cristina Roque, Henrique Duarte, Pedro Terrinha, Vasco Valadares, João Noiva, Mário Cachão, Joana Ferreira, Paulo Legoinha, Nevio Zitellini,
The contourite drifts off southwest Iberia that formed as a result of the interaction of the Mediterranean Outflow Water (MOW) with the continental middle slope were studied in the Algarve margin using multichannel reflection seismic lines, oil-wells, piston cores, and a bathymetric compilation of four datasets. The seismostratigraphic interpretation of a dense array of oil industry seismic and stratigraphic correlation allowed the identification of five seismic units of Early Pliocene through Holocene ...
Tópico(s): Geology and Paleoclimatology Research
2011 - Elsevier BV | Marine Geology
Vasco Manquinho, João Marques‐Silva,
Cutting planes are a well-known, widely used, and very effective technique for Integer Linear Programming (ILP).However, cutting plane techniques are seldom used in Pseudo-Boolean Optimization (PBO) algorithms.This paper addresses the utilization of Gomory mixed-integer and clique cuts, in Satisfiability-based algorithms for PBO, and shows how these cuts can be used for computing lower bounds and for learning new constraints.A side result of learning new constraints is that the utilization of cutting ...
Tópico(s): Advanced Graph Theory Research
2006 - IOS Press | Journal on Satisfiability Boolean Modeling and Computation
Miguel S. Costa, Vasco Gonçalves, João Penedones,
We generalize Regge theory to correlation functions in conformal field theories. This is done by exploring the analogy between Mellin amplitudes in AdS/CFT and S-matrix elements. In the process, we develop the conformal partial wave expansion in Mellin space, elucidating the analytic structure of the partial amplitudes. We apply the new formalism to the case of four point correlation functions between protected scalar operators in $ \mathcal{N}=4 $ Super Yang Mills, in cases where the Regge limit is ...
Tópico(s): Cosmology and Gravitation Theories
2012 - Springer Nature | Journal of High Energy Physics
Isabel Sousa, Vasco Claro, João Lino Pereira, Ana Luísa Amaral, Luís Cunha‐Silva, Baltazar de Castro, Maria J. Feio, Eulália Pereira, Paula Gameiro,
Solution behavior of levofloxacin (lvx) complexes with copper(II) in the presence and absence of phen was studied in aqueous solution, by potentiometry. The results obtained show that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):lvx:phen ternary complexes are stable. Hence, a novel copper(II) ternary complex of fluoroquinolone levofloxacin with nitrogen donor heterocyclic ligand phen was synthesized and characterized by means of UV–Visible and IR spectroscopy, ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - Elsevier BV | Journal of Inorganic Biochemistry
Vasco Branco, João Canário, Carlos Vale, Joana Raimundo, Carlos Reis,
Tópico(s): Isotope Analysis in Ecology
2004 - Elsevier BV | Marine Pollution Bulletin
Vasco Manquinho, João Marques‐Silva,
This paper proposes new algorithms for the Binate Covering Problem (BCP), a well-known restriction of Boolean Optimization. Binate Covering finds application in many areas of Computer Science and Engineering. In Artificial Intelligence, BCP can be used for computing minimum-size prime implicants of Boolean functions, of interest in Automated Reasoning and Non-Monotonic Reasoning. Moreover, Binate Covering is an essential modeling tool in Electronic Design Automation. The objectives of the paper are ...
Tópico(s): VLSI and Analog Circuit Testing
2004 - Springer Science+Business Media | Annals of Mathematics and Artificial Intelligence
Miguel S. Costa, J. M. Drummond, Vasco Gonçalves, João Penedones,
We study two kinematical limits, the Regge limit and the Lorentzian OPE limit, of the four-point function of the stress-tensor multiplet in Super Yang-Mills at weak coupling. We explain how both kinematical limits are controlled by the leading twist operators. We use the known expression of the four-point function up to three loops, to extract the pomeron residue at next-to-leading order. Using this data and the known form of pomeron spin up to next-to-leading order, we predict the behaviour of ...
Tópico(s): Quantum Chromodynamics and Particle Interactions
2014 - Springer Nature | Journal of High Energy Physics
Teresa Ribeiro‐Rodrigues, Steve Catarino, Carla Marques, João Vasco Ferreira, Tânia Martins‐Marques, Paulo Pereira, Henrique Girão,
Gap junctions (GJs) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct intercellular communication between eukaryotic cells. Although Cx43 has long been known to be a substrate for ubiquitination, the reversal of this modification by deubiquitylases (DUBs) has never been described. Here we report that the DUB-associated molecule with the SH3 domain of STAM (AMSH) interacts with Cx43 and mediates its deubiquitination. In this study, we demonstrate that Cx43 is modified ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2014 - Wiley | The FASEB Journal
Produção Nacional
Revisado por pares
João Guilherme Dal Belo Leite, João Vasco Silva, M.K. van Ittersum,
With many of the poor people in Brazil living in rural areas, local governments have intensified their efforts to design and implement effective policies that boost rural development. In 2004, a national program for production and use of biodiesel was launched aiming at increasing income among less endowed family farmers across the country. With expectations building on further expansion of the mandatory blending of biodiesel with fossil diesel, national and local government bodies are challenged ...
Tópico(s): Water-Energy-Food Nexus Studies
2014 - Elsevier BV | Agricultural Systems
Produção Nacional
Revisado por pares
João Guilherme Dal Belo Leite, João Vasco Silva, Flávio Justino, M.K. van Ittersum,
Pushed by the Brazilian biodiesel policy, sunflower (Helianthus annuus L.) production is becoming increasingly regarded as an option to boost farmers' income, particularly under semi-arid conditions. Biodiesel related opportunities increase the demand for decision-making information at different levels, which could be met by simulation models. This study aimed to evaluate the performance of the crop model OILCROP-SUN to simulate sunflower development and growth under Brazilian conditions and to explore ...
Tópico(s): Climate change impacts on agriculture
2014 - UNIVERSIDADE DE SÃO PAULO | Scientia Agricola
Miguel S. Costa, Vasco Gonçalves, João Penedones,
We develop the embedding formalism to describe symmetric traceless tensors in Anti-de Sitter space. We use this formalism to construct the bulk-to-bulk propagator of massive spin J fields and check that it has the expected short distance and massless limits. We also find a split representation for the bulk-to-bulk propagator, by writing it as an integral over the boundary of the product of two bulk-to-boundary propagators. We exemplify the use of this representation with the computation of the conformal ...
Tópico(s): Noncommutative and Quantum Gravity Theories
2014 - Springer Nature | Journal of High Energy Physics
Produção Nacional
Revisado por pares
Luiz H. A. Correia, Thanh-Dien Tran, Vasco Pereira, João Carlos Giacomin, Jorge Sá Silva,
The growth of mobile and ubiquitous computing has increased the demand for wireless communications, which in turn raises interference levels and spectrum pollution, causing problems of network coexistence. The coexistence assurance between these devices and wireless sensor networks is a big challenge. This paper proposes a new medium access protocol, DynMAC (Dynamic MAC), which uses mechanisms of dynamic channel reconfiguration, recovery from lost links and reconfiguration of transmission parameters ...
Tópico(s): Security in Wireless Sensor Networks
2014 - Elsevier BV | Computer Networks
Produção Nacional
Revisado por pares
João Guilherme Dal Belo Leite, Flávio Justino, João Vasco Silva, Madeleine Florin, M.K. van Ittersum,
In Brazil, local agricultural research agendas are increasingly challenged by the search for sustainable biodiesel crop options for family farmers, especially under semi-arid conditions. The aim of this paper is to explore the suitability of different biodiesel crops (i.e. soybean, castor bean and sunflower) through a set of environmental and socioeconomic indicators in a semi-arid (Montes Claros) and a more humid (Chapada Gaúcha) municipality in the state of Minas Gerais, southeast Brazil. A technical ...
Tópico(s): Cassava research and cyanide
2014 - Elsevier BV | Agricultural Systems
Produção Nacional
Revisado por pares
Gabriel Gustinelli Arantes de Carvalho, Iracema Alves Manoel Degaspari, Vasco Branco, João Canário, Alberto Ferreira de Amorim, V. H. Kennedy, José Roberto Ferreira,
Tópico(s): Marine animal studies overview
2014 - Springer Science+Business Media | Biological Trace Element Research
João Vasco Ferreira, Hugo Miguel Veríssimo Fôfo, Eloy Bejarano, Carla F. Bento, José S. Ramalho, Henrique Girão, Paulo Pereira,
The transcription factor HIF1 is mostly regulated by the oxygen-dependent proteasomal degradation of the labile subunit HIF1A. Recent data showed degradation of HIF1A in the lysosome through chaperone-mediated autophagy (CMA). However the molecular mechanism involved has not been elucidated. This study shows that the KFERQ-like motif, that has been identified in all CMA substrates, is required to mediate the interaction between HIF1A and the chaperone HSPA8. Moreover, mutations in the KFERQ-like ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2013 - Taylor & Francis | Autophagy