José Neves, M. Rosário Martins, João Vilhena, João Neves, Sabino Gomes, António Abelha, José Machado, Henrique Vicente,
Kidney renal failure means that one's kidney have unexpectedly stopped functioning, i.e., once chronic disease is exposed, the presence or degree of kidney dysfunction and its progression must be assessed, and the underlying syndrome has to be diagnosed. Although the patient's history and physical examination may denote good practice, some key information has to be obtained from valuation of the glomerular filtration rate, and the analysis of serum biomarkers. Indeed, chronic kidney sickness depicts ...
Tópico(s): Data Mining Algorithms and Applications
2015 - Springer Science+Business Media | Journal of Medical Systems
Francisca Dias, Ana Luísa Teixeira, Inês Nogueira, Mariana Morais, Joana Maia, Cristian Bodo, M. Ferreira, Alexandra Silva, Manuela Vilhena, João Lobo, José Pedro Sequeira, Joaquina Maurício, Jorge Oliveira, Klaas Kok, Bruno Costa‐Silva, Rui Medeiros,
Clear cell renal cell carcinoma (ccRCC) is the most aggressive subtype of kidney cancer and up to 40% of patients submitted to surgery with a curative intent will relapse. Thus, the aim of this study was to analyze the applicability of an Extracellular vesicle (EV) derived miRNA profile as potential prognosis biomarkers in ccRCC patients. We analyzed a nine-miRNA profile in plasma EVs from 32 ccRCC patients with localized disease (before and after surgery) and in 37 patients with metastatic disease. ...
Tópico(s): Renal and related cancers
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Pedro Arsénio, T. Silva, Nuno Vilhena, João Murta-Pina, Anabela Pronto,
Magnetic shielding inductive fault current limiters with high temperature superconducting cylinders have previously been described by a characteristic (or maximum) hysteresis loop, built from properties of their constitutive parts, which allowed predicting their behavior in electrical grids. These preliminary results were based on finite element simulations, but posterior experiments suggested limitations in the models. In order to investigate the application of these previous models to real devices, ...
Tópico(s): Ionosphere and magnetosphere dynamics
2012 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
João Vilhena, Henrique Vicente, M. Rosário Martins, José M. Grañeda, Filomena Caldeira, Rodrigo Gusmão, João Neves, José Neves,
Thrombophilia stands for a genetic or an acquired tendency to hypercoagulable states that increase the risk of venous and arterial thromboses. Indeed, venous thromboembolism is often a chronic illness, mainly in deep venous thrombosis and pulmonary embolism, requiring lifelong prevention strategies. Therefore, it is crucial to identify the cause of the disease, the most appropriate treatment, the length of treatment or prevent a thrombotic recurrence. Thus, this work will focus on the development ...
Tópico(s): AI-based Problem Solving and Planning
2016 - Elsevier BV | Journal of Biomedical Informatics
Nuno Vilhena, João Murta-Pina, Anabela Pronto, Alfredo Álvarez,
Superconducting fault current limiters (SFCL) have already demonstrated their viability in electric power grids. The growth in distributed generation sources and an increased interconnection of networks tend to increase the complexity of electric power grids, rising the number of failures, especially short circuits. To disseminate these technologies, the development of straightforward design tools is required. These tools must consider the properties of the available constitutive elements of the ...
Tópico(s): Superconducting Materials and Applications
2018 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
Produção Nacional
Revisado por pares
Luis Figueredo, Bruno Vilhena Adorno, João Y. Ishihara,
This paper proposes a robust dual-quaternion based H∞ task-space kinematic controller for robot manipulators. To address the manipulator liability to modeling errors, uncertainties, exogenous disturbances, and their influence upon the kinematics of the end-effector pose, we adapt H∞ techniques – suitable only for additive noises – to unit dual quaternions. The noise to error attenuation within the H∞ framework has the additional advantage of casting aside requirements concerning noise distributions, ...
Tópico(s): Robot Manipulation and Learning
2021 - Elsevier BV | Automatica
João Vilhena, Henrique Vicente, M. Rosário Martins, José M. Grañeda, Filomena Caldeira, Rodrigo Gusmão, João Neves, José Neves,
Thrombophilia stands for a genetic or an acquired tendency to hypercoagulable states, frequently as venous thrombosis. Venous thromboembolism, represented mainly by deep venous thrombosis and pulmonary embolism, is often a chronic illness, associated with high morbidity and mortality. Therefore, it is crucial to identify the cause of the disease, the most appropriate treatment, the length of treatment or prevent a thrombotic recurrence. This work will focus on the development of a diagnosis decision ...
Tópico(s): Topic Modeling
2017 - IGI Global | International Journal of Reliable and Quality E-Healthcare
Produção Nacional
Revisado por pares
Alyne Fonseca de Vilhena, João Carlos das Neves Pereira, Edwin R. Parra, Marcelo Luiz Balancin, Alexandre Ab ́Saber, Vanessa Martins, Cecília Farhat, Marcelo Militão Abrantes, José Ribas Milanez de Campos, Miguel Lia Tedde, Teresa Yae Takagaki, Vera Luíza Capelozzi,
Ki-67 has shown promise as a prognostic factor in pulmonary carcinoids. In this study, we sought to validate the importance of Ki-67 and study the relationships between Ki-67 and other stromal biomarkers of vascular density. We examined Ki-67, CD34, and D2-40 in tumor tissues from 128 patients with surgically excised typical carcinoid of the lung. We used immunohistochemistry and morphometry to evaluate the amount of tumor staining for cellular proliferation (Ki-67), microvascular density (CD34-MVD), ...
Tópico(s): Neuroblastoma Research and Treatments
2018 - Elsevier BV | Human Pathology
Nuno Vilhena, Pedro Arsénio, João Murta-Pina, Anabela Pronto, Alfredo Álvarez,
Inductive fault current limiters, such as saturated cores topology, have been considered as an enabling technology for the advent of modern power grids. Thereby, several full-scale prototypes have been developed in recent years aiming, e.g., supporting increased penetration of dispersed generation, mostly from renewable sources. For the advent of these devices and technology, the development of straightforward design tools that allow simulating them in electrical power grids with different voltage ...
Tópico(s): Power Systems Fault Detection
2014 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
Ana Canadas, Miguel França, Cristina Pereira, Raquel Vilaça, Hugo Vilhena, Flora Tinoco, Maria João Silva, Jorge Ribeiro, Rui Medeiros, Pedro Oliveira, Patrícia Dias‐Pereira, Marta Santos,
Histopathology remains the cornerstone for diagnosing canine mammary tumors (CMTs). Recently, 2 classification systems (the World Health Organization [WHO] classification of 1999 and the proposal of 2011) and 2 grading methods based on the human Nottingham grade have been used by pathologists. Despite some evidence that the histological subtype and grade are prognostic factors, there is no comprehensive comparative study of these classification and grading systems in the same series of CMTs. In this ...
Tópico(s): Oral and Maxillofacial Pathology
2018 - SAGE Publishing | Veterinary Pathology
Ana Coelho, Luís Vilhena, Maria João Antunes, Inês Amaro, Anabela Paula, Carlos Miguel Marto, José Saraiva, Manuel Marques Ferreira, Eunice Carrilho, A. Ramalho,
After the elimination of dental caries lesions, some microorganisms may remain viable in the tooth structure. Thus, cavity disinfection is an important procedure. The aim of this study was to evaluate the effect of cavity disinfectants on the adhesion to dentin of permanent teeth. Sixty molars were ground flat and randomly assigned to six groups: control; chlorhexidine; Aloe vera; glutaraldehyde; EDTA; ethanol. Cavity disinfectants were applied, rinsed, and air-dried. The restorations were performed ...
Tópico(s): Dental Erosion and Treatment
2022 - Multidisciplinary Digital Publishing Institute | Journal of Functional Biomaterials
Produção Nacional
Revisado por pares
Guilherme Kemeron Maciel Salazar, Joseir Saturnino Cristino, Alexandre Vilhena Silva-Neto, Altair Seabra de Farias, João Arthur Alcântara, Vinícius Azevedo Machado, Felipe Murta, Vanderson de Souza Sampaio, Fernando Val, André Sachett, Paulo Sérgio Bernarde, Marcus Lacerda, Fan Hui Wen, Wuelton Marcelo Monteiro, Jacqueline de Almeida Gonçalves Sachett,
In the Brazilian Amazon, long distances, low healthcare coverage, common use of ineffective or deleterious self-care practices, and resistance to seeking medical assistance have an impact on access to antivenom treatment. This study aimed to estimate snakebite underreporting, and analyze barriers that prevent victims from obtaining healthcare in communities located in 15 municipalities on the banks of the Solimões, Juruá and Purus Rivers, in the remote Western Brazilian Amazon. Information on the ...
Tópico(s): Yersinia bacterium, plague, ectoparasites research
2021 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
João Luís Nunes Carvalho, Carlos Eduardo Pellegrino Cerri, Carlos Clemente Cerri, Brigitte Josefine Feigl, Marisa de Cássia Píccolo, V.P.C. Godinho, Uwe Herpin,
Tópico(s): Clay minerals and soil interactions
2007 - Elsevier BV | Soil and Tillage Research
Carlos Roncero‐Clemente, Nuno Vilhena, Vasco Delgado‐Gomes, Enrique Romero‐Cadaval, João Martins,
From the electrical energy point of view, the smart community (SC) concept is meant to be as a sustainable and environmentally friendly alternative to the classical configuration. The SC includes small-scale renewable energy sources (RES) and small-scale energy storage system (ESS). The SC energy management system acts as an aggregator, aiming to assure benefits for community stakeholders. These trends led to the energy routers (ERs) concept. This study proposes and describes the control strategies ...
Tópico(s): Advanced Battery Technologies Research
2019 - Institution of Engineering and Technology | IET Renewable Power Generation
João Vilhena, M. Rosário Martins, Henrique Vicente, José M. Grañeda, Filomena Caldeira, Rodrigo Gusmão, João Neves, José Neves,
The AntiPhospholipid Syndrome (APS) is an acquired autoimmune disorder induced by high levels of antiphospholipid antibodies that cause arterial and veins thrombosis, as well as pregnancy-related complications and morbidity, as clinical manifestations. This autoimmune hypercoagulable state, usually known as Hughes syndrome, has severe consequences for the patients, being one of the main causes of thrombotic disorders and death. Therefore, it is required to be preventive; being aware of how probable ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2017 - Springer Science+Business Media | Journal of Medical Systems
Produção Nacional
Revisado por pares
Hugo T. M. Kussaba, Luis Figueredo, João Y. Ishihara, Bruno Vilhena Adorno,
In this paper, we address the rigid body pose stabilization problem using dual quaternion formalism. We propose a hybrid control strategy to design a switching control law with hysteresis in such a way that the global asymptotic stability of the closed-loop system is guaranteed and such that the global attractivity of the stabilization pose does not exhibit chattering, a problem that is present in all discontinuous-based feedback controllers. Using numerical simulations, we illustrate the problems ...
Tópico(s): Dynamics and Control of Mechanical Systems
2017 - Elsevier BV | Journal of the Franklin Institute
... doutoramento em Historia da Arte apresentada por Maria Joao Vilhena de Carvalho, no ano de 2014, a Faculdade ...
Tópico(s): Cultural Identity and Heritage
2020 - University of Évora | Midas
Nuno Vilhena, Pedro Arsénio, João Murta-Pina, Anabela Pronto, Alfredo Álvarez,
Superconducting fault current limiters are considered as emerging devices for the advent of modern power grids. Those limiters as well as other electric power grid applications have been developed in the last years in order to support the increased penetration of dispersed generation. The development of such limiters requires new design tools that allows to simulate those devices in electrical power grids with different voltage ratings and characteristics. This work presents a methodology to simulate ...
Tópico(s): Magnetic Field Sensors Techniques
2015 - Springer Science+Business Media | IFIP advances in information and communication technology
Produção Nacional
Revisado por pares
Joseir Saturnino Cristino, Guilherme Maciel Salazar, Vinícius Azevedo Machado, Eduardo Jorge Sant’Ana Honorato, Altair Seabra de Farias, João Ricardo Nickenig Vissoci, Alexandre Vilhena Silva Neto, Marcus Lacerda, Fan Hui Wen, Wuelton Marcelo Monteiro, Jacqueline de Almeida Gonçalves Sachett,
Access to antivenoms is not guarranteed for vulnerable populations that inhabit remote areas in the Amazon. The study of therapeutic itineraries (TI) for treatment of snakebites would support strategies to provide timely access to users. A TI is the set of processes by which individuals adhere to certain forms of treatment, and includes the path traveled in the search for healthcare, and practices to solve their health problems. This study aims to describe TIs of snakebite patients in the Brazilian ...
Tópico(s): Mosquito-borne diseases and control
2021 - Public Library of Science | PLoS neglected tropical diseases
Nuno Vilhena, Amanda Taillacq, Anabela Pronto, João Murta-Pina, Alfredo Álvarez,
Electrodynamic forces developed under short-circuit events must be well characterized in power-grid applications, as they can compromise the integrity of network systems, particularly power transformers, but also inductive superconducting fault current limiters (SFCLs). These strains can destroy windings causing failure of the devices and affecting power-grid operation. In this paper, the analysis of electrodynamic forces developed in an inductive SFCL of transformer type under such extreme conditions ...
Tópico(s): Superconducting Materials and Applications
2016 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
Produção Nacional
Revisado por pares
Cleydlenne Costa Vasconcelos, Alberto Jorge Oliveira Lopes, Emerson Lucas Frazão Sousa, Darleno Sousa Camelo, Fernando César Vilhena Moreira Lima, Cláudia Quintino da Rocha, Gyl Eanes Barros Silva, João Batista Santos Garcia, Maria do Socorro de Sousa Cartágenes,
The aim of this study was to analyze the analgesic potential of Arrabidaea chica extract (EHA) as an alternative to osteoarthritis (OA) treatment. Thus, the extract was initially evaluated by the cyclooxygenase inhibition test. The analgesic effect of the extract, in vivo, was also verified in a model of OA induced by sodium monoiodoacetate (2 mg). EHA was administered to rats at doses of 50, 150, and 450 mg/kg between 3 and 25 days after OA induction. The animals were clinically evaluated every 7 ...
Tópico(s): Phytochemistry and Biological Activities
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Rômulo Pereira Ribeiro, João Cleverson Gasparetto, Raquel de Oliveira Vilhena, Thais Martins Guimarães de Francisco, Cleverson Antônio Ferreira Martins, Marco André Cardoso, Roberto Pontarolo, Katherine Athayde Teixeira de Carvalho,
Background: In this study, we developed and validated a HPLC–MS/MS method capable of simultaneously determining levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma. Results & methodology: Chromatographic separation was achieved using a C8 column with a mobile phase consisting of a gradient of water and acetonitrile:methanol (90:10 v/v), both containing 0.1% formic acid. The developed method was selective, sensitive (LD 0.99), precise (RSD < 11.3%), accurate (RE < 11.8%) ...
Tópico(s): Electrochemical sensors and biosensors
2015 - Future Science Ltd | Bioanalysis
Produção Nacional
Revisado por pares
João Soares Felício, Hana Andrade de Rider Britto, Pedro Celeira Cortez, Fabrício de Souza Resende, Manuela Nascimento de Lemos, Lorena Vilhena de Moraes, Vitória Teixeira de Aquino, Fernanda de Souza Parente, Natércia Neves Marques de Queiroz, João Felício Abrahão Neto, Angélica Leite de Alcântara, Wanderson Maia da Silva, Norberto Jorge Kzan de Souza Neto, Pedro Paulo Freire Piani, Ícaro José Araújo de Souza, Lilian de Souza D’Albuquerque Silva, Maria Clara Neres Iunes de Oliveira, Nivin Mazen Said, Gabriela Nascimento de Lemos, Franciane Trindade Cunha de Melo, Daniela Lopes Gomes, Ana Carolina Contente Braga de Souza, Melissa de Sá Oliveira dos Reis, Valéria Suênya Galvão Leal, Isabel Jane Campos Lobato, Karem Miléo Felício,
Background The effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified. Objective Evaluate the relationship between 25-hydroxy-vitamin D [25(OH)D], HbA1c, and albuminuria in Diabetes Mellitus (DM). Patients and Methods Cross-sectional study with 1576 individuals with DM who had 25(OH)D, HbA1c, and ...
Tópico(s): Bariatric Surgery and Outcomes
2021 - Frontiers Media | Frontiers in Endocrinology
Produção Nacional
Revisado por pares
Rafaella Sousa Ferraz, Lucas Cauê Bezerra Santos, Rebecca Lais da-Silva-Cruz, Cintia Helena Braga-da-Silva, Leandro Magalhães, Arthur Ribeiro-dos-Santos, Amanda Vidal, Tatiana Vinasco‐Sandoval, Laís Reis-das-Mercês, Camille Sena-dos-Santos, Adenilson Leão Pereira, Lilian Souza D’Albuquerque Silva, Franciane T. Cunha de Melo, Ana Carolina C. Braga de Souza, Valéria S. Galvão Leal, Priscila B. Barbosa de Figueiredo, João F. Abrahão Neto, Lorena Vilhena de Moraes, Gabriela Nascimento de Lemos, Natércia Neves Marques de Queiroz, Karem Miléo Felício, Giovanna C. Cavalcante, Ândrea Ribeiro‐dos‐Santos, João Soares Felício,
Considering the potential role of miRNAs as biomarkers and their interaction with both nuclear and mitochondrial genes, we investigated the miRNA expression profile in type 1 diabetes (T1DM) patients, including the pathways in which they are involved considering both nuclear and mitochondrial functions.We analyzed samples of T1DM patients and control individuals (normal glucose tolerance) by high throughput miRNA sequencing (miRNome). Next, five miRNAs - hsa-miR-26b-5p, hsa-let-7i-5p, hsa-miR-143-3p, ...
Tópico(s): RNA modifications and cancer
2022 - Frontiers Media | Frontiers in Endocrinology
Produção Nacional
Revisado por pares
Natacha Malu Miranda da Costa, Russell Santiago Correa, Ismael Júnior, Adilson Figueiredo, Kelly Vilhena, Paulo Mecenas, Francisco Bruno Teixeira, Nayana Ferreira, João B. Pereira, Kelly das Graças Fernandes Dantas, Marcia Silva, Ademir Ferreira da Silva-Júnior, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro, Rafael Rodrigues Lima,
Aluminum absorption leads to deposits in several tissues. In this study, we have investigated, to our knowledge for the first time, aluminum deposition in the salivary glands in addition to the resultant cellular changes in the parotid and submandibular salivary glands in a model of chronic intoxication with aluminum citrate in rats. Aluminum deposits were observed in the parotid and submandibular glands. Immunohistochemical evaluation of cytokeratin-18 revealed a decreased expression in the parotid ...
Tópico(s): Heavy Metal Exposure and Toxicity
2014 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Produção Nacional
Revisado por pares
Marcus Vinícius Viégas Lima, Abner de Oliveira Freire, Emerson Lucas Frazão Sousa, André Álvares Marques Vale, Alberto Jorge Oliveira Lopes, Cleydlenne Costa Vasconcelos, Mônica Virginia Viégas Lima-Aragão, Humberto Oliveira Serra, Rosane Nassar Meireles Guerra Liberio, Ana Paula Silva de Azevedo dos Santos, Gyl Eanes Barros Silva, Cláudia Quintino da Rocha, Fernando César Vilhena Moreira Lima, Maria do Socorro de Sousa Cartágenes, João Batista Santos Garcia,
Pain is recognized as one of the main symptoms in knee osteoarthritis and is the main reason why patients seek medical attention. Scoparia dulcis has been popularly used to relieve discomfort caused by various painful conditions. The objective of the study is to evaluate the analgesic and anti-inflammatory effect of the crude extract of S. dulcis, in an experimental model of osteoarthritis. The experiment was performed with Wistar rats divided into 4 groups with 5 animals each: healthy, saline, ...
Tópico(s): Inflammatory mediators and NSAID effects
2019 - Multidisciplinary Digital Publishing Institute | Molecules
M. Fátima Cabral, Judite Costa, Rita Delgado, João J. R. Fraústo da Silva, M.Fernanda Vilhena,
Some 9- and 10-membered oxa-diaza macrocyclic ligands and their N-acetate derivatives have been synthesized and their protonation patterns studied by 1H NMR and potentiometric techniques. The stability constants of the complexes formed by these ligands with several alkaline-earth and first-series transition metal ions, zinc, cadmium and lead, were determined by potentiometry and the values were compared with those formed with the analogous 9-membered tri-aza macrocyclic ligands and with 12-membered ...
Tópico(s): Molecular Sensors and Ion Detection
1990 - Elsevier BV | Polyhedron
Produção Nacional
Revisado por pares
Gabriel dos Santos, Felipe Sass, Vitor Hugo, Guilherme Gonçalves Sotelo, Nuno Vilhena, Roberto Oliveira, Anabela Pronto, João Murta-Pina,
A dc-bias high-temperature superconducting (HTS) coil is the main part of the Saturated Iron Core Fault Current Limiter (SIC-SFCL). Another relevant part of the SIC-SFCL is the iron core, which represents the main volume of the device. Therefore, optimizing the iron core volume decreases the equipment cost significantly. Also, it is important to find an optimized geometry for the dc HTS coil that allows extracting the maximum potential of the superconducting material. This article proposes a full ...
Tópico(s): Superconducting Materials and Applications
2022 - IEEE Council on Superconductivity | IEEE Transactions on Applied Superconductivity
Ricardo Ferreira, João Murta-Pina, Nuno Vilhena, Pedro Arsénio, Anabela Pronto, João Martins,
Inductive fault current limiters of magnetic shielding type can be described in terms of the excursion in the plane defined by flux linked with primary and line current, and this methodology has been previously applied to single-phase devices. Practical applications, however, require three-phase limiters, which, for the sake of compactness, may be built by three legged cores, instead of three single phase units. This has the advantage of using well established methods of power transformers industry, ...
Tópico(s): High-Voltage Power Transmission Systems
2014 - IOP Publishing | Journal of Physics Conference Series
Produção Nacional
Adalgisa da Silva Alvarez, Raimunda Conceição de Vilhena Potiguara, João Ubiratan Moreira dos Santos,
Foi realizado o estudo da venação foliar de seis espécies de Eugenia L. (Myrtaceae), da restinga de Algodoal, Maiandeua, estado do Pará. A análise das espécies mostra que todas apresentaram venação broquidródomo não sendo possível separá-las por este caráter, pois não houve diferença no padrão de venação, contudo, foram encontrados alguns caracteres anatômicos diferenciais que levaram à construção de uma chave analítica para auxiliar na identificação das espécies.
Tópico(s): Plant Diversity and Evolution
2006 - | Boletim do Museu Paraense Emílio Goeldi - Ciências Naturais