Produção Nacional
Revisado por pares
Denise Delvalle-Borrero, José Fábrega, Jorge Olmos, Ostin Garcés-Ordóñez, Sônia Silva Gurgel do Amaral, Mariana Vezzone, João Paulo de Sá Felizardo, R. M. Anjos,
Microplastics are a global ubiquitous problem, which is becoming a major issue of concern at scientific and political levels around the world. This study presents physical and chemical characterizations of microplastic debris and a comparison between the spatial distribution and anthropogenic activities in 4 Panamanian beaches located in both sides of the Isthmus. Two of them (Juan Diaz and San Carlos beaches) are located toward the Pacific Ocean, Panamá Province, whereas the others (Palenque and ...
Tópico(s): biodegradable polymer synthesis and properties
2020 - SAGE Publishing | Air Soil and Water Research
Produção Nacional
Revisado por pares
Bruno C. Cavalcanti, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Antônio Adailson de Sousa Silva, Maria Erivanda França Rios, Francisco Stefânio Barreto, José Roberto de Oliveira Ferreira, Cecília Rocha da Silva, Fátima Daiana Dias Barroso, Hemerson Iury Ferreira Magalhães, Hélio Vitoriano Nobre Júnior, Manoel O. de Moraes,
No carcinogenesis or mutagenesis studies have been carried out with etomidate. The current study showed that etomidate has weak cytotoxic potential after 48 h exposure in human lymphocytes and has no hemolytic activity. The weak cytotoxicity seems to be related with redox imbalance of etomidate (40.9 and 81.9 μM) treated lymphocytes. At both etomidate concentrations, a slight decrease of the levels of GSH intracellular content and a significant increase in the amount of carbonylated proteins were ...
Tópico(s): bioluminescence and chemiluminescence research
2020 - Elsevier BV | Toxicology in Vitro
Produção Nacional
Revisado por pares
Ito Liberato, Leticia A Lino, Juan K D Souza, João BA Neto, Lívia Gurgel do Amaral Valente Sá, Vitória PF Cabral, Cecília Rocha da Silva, Bruno C. Cavalcanti, Manoel Odorico de Moraes, V. N. Freire, Hélio Vitoriano Nobre Júnior, Claudia Roberta de Andrade,
Aim: To evaluate the antifungal activity of gallic acid (GA) against the strains of Candida spp. resistant to fluconazole and to determine its mechanism of action. Materials & methods: Antifungal activity was evaluated using the broth microdilution and flow cytometry techniques. Results: GA presented minimum inhibitory concentrations ranging from 16 to 72 μg/ml, causing alterations of the membrane integrity and mitochondrial transmembrane potential, production of reactive oxygen species and externalization ...
Tópico(s): Essential Oils and Antimicrobial Activity
2022 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João Batista de Andrade Neto, Francisca Bruna Stefany Aires do Nascimento, Fátima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Jacilene Silva, Emmanuel Silva Marinho, Manoel Odorico de Moraes, Maria Erivanda França Rios, Bruno C. Cavalcanti, Iri Sandro Pampolha Lima, Hélio Vitoriano Nobre Júnior,
This study evaluated the effect of etomidate against biofilms of Candida spp. and analysed through molecular docking the interaction of this drug with ALS3, an important protein for fungal adhesion. Three fluconazole-resistant fungi were used: Candida albicans, Candida parapsilosis and Candida tropicalis. Growing biofilms were exposed to etomidate at 31.25-500 µg ml-1. Then, an ALS3 adhesive protein from C. albicans was analysed through a molecular mapping technique, composed of a sequence of algorithms ...
Tópico(s): Fungal Infections and Studies
2020 - Microbiology Society | Journal of Medical Microbiology
Produção Nacional
Revisado por pares
Maria AV Holanda, Cecília Rocha da Silva, João Batista de Andrade Neto, Lívia Gurgel do Amaral Valente Sá, Francisca Bruna Stefany Aires do Nascimento, Daiana D Barroso, Lisandra J da Silva, Thiago M Cândido, Amanda C Leitão, Amanda Dias Barbosa, Manoel Odorico de Moraes, Bruno Coelho Cavalcânti, Hélio Vitoriano Nobre Júnior,
Aim: The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical Candida spp. in planktonic and biofilm form. Materials & methods: The antifungal activity was observed using the broth microdilution technique. Flow cytometry tests were performed to investigate the probable mechanism of action and the comet test and cytotoxicity test were applied to evaluate DNA damage. Results: Midazolam (MIDAZ) showed antifungal ...
Tópico(s): Antifungal resistance and susceptibility
2021 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
A. A. Souza, Adrianne Maia Lima, Daniele dede Oliveira BezerraSousa, Francisca Cristiane Nogueira, José Carlos do Sacramento Neto, Lucas Pinheiro Dias, Nadine Monteiro Salgueiro Araújo, Celso Shiniti Nagano, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Fátima Daiana Dias Barroso, Maria Elisabete Amaral de Moraes, Hermógenes David de Oliveira,
The emergence of antibiotic resistance poses a serious and challenging threat to healthcare systems, making it imperative to discover novel therapeutic options. This work reports the isolation and characterization of a thermostable trypsin inhibitor from chia (Salvia hispanica L.) seeds, with antibacterial activity against Staphylococcus aureus sensitive and resistant to methicillin. The trypsin inhibitor ShTI was purified from chia seeds through crude extract heat treatment, followed by affinity ...
Tópico(s): Polysaccharides Composition and Applications
2022 - Springer Science+Business Media | Probiotics and Antimicrobial Proteins
Produção Nacional
Revisado por pares
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João Batista de Andrade Neto, Thiago M Cândido, Leilson C de Oliveira, Francisca Bruna Stefany Aires do Nascimento, Fátima DD Barroso, Lisandra J da Silva, Jacó RL de Mesquita, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,
Aim: The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. Materials & methods: The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used. Results: MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2020 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Helaine Almeida Queiroz, Cecília Rocha da Silva, João Batista de Andrade Neto, Lívia Gurgel do Amaral Valente Sá, Francisca Bruna Stefany Aires do Nascimento, Letícia Serpa Sampaio Moreno, Fátima DD Barroso, Lisandra J da Silva, Thiago M Cândido, Leilson C de Oliveira, Jacó RL de Mesquita, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,
Aim: To evaluate the activity of diclofenac sodium and synergism with oxacillin against clinical strains of SARM in plactonic cells, antibiofilm and biofilm. Materials & methods: Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry. Results: The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant Staphylococcus ...
Tópico(s): Antimicrobial agents and applications
2021 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, S Campos de Rosana, João B A de Neto, Sandro Serpa, Francisca Bruna Stefany Aires do Nascimento, Fátima DD Barroso, Lisandra J da Silva, Helaine Almeida Queiroz, Thiago M Cândido, Daniel Sampaio Rodrigues, Amanda C Leitão, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,
Aim: The purpose of this study was to evaluate the effect of etomidate alone and in combination with azoles on resistant strains of Candida spp. in both planktonic cells and biofilms. Materials & methods: The antifungal activity of etomidate was assessed by the broth microdilution test; flow cytometric procedures to measure fungal viability, mitochondrial transmembrane potential, free radical generation and cell death; as well detection of DNA damage using the comet assay. The interaction between ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2019 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
José Luiz Oliverio, Fernando C. Boscariol, Paulo E. Mantelatto, Antônio Rogério P. César, João R. P. Ciambelli, Marcílio N. do Amaral Gurgel, Renata Torres Gomes de Souza,
Tópico(s): Biofuel production and bioconversion
2011 - Springer Science+Business Media | Sugar Tech
Produção Nacional
Revisado por pares
João Batista de Andrade Neto, Cecília Rocha da Silva, Fátima Daiana Dias Barroso, Lívia Gurgel do Amaral Valente Sá, Rosana de Sousa Campos, Francisca Bruna Stefany Aires do Nascimento, Sandro Serpa, Anderson Ramos da Silva, Lisandra Juvêncio da Silva, Igor de Sá Carneiro, Helaine Almeida Queiroz, Jacó Ricarte Lima de Mesquita, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
The emergence of Candida spp. with resistance to antifungal molecules, mainly the azole class, is an increasing complication in hospitals around the globe. Aim: In the present research, we evaluated the synergistic effects of ketamine with two azole derivatives, itraconazole and fluconazole, on strains of Candida spp. to fluconazole. Materials & methods: The drug synergy was evaluated by quantifying the fractional inhibitory concentration index and by fluorescence microscopy and flow cytometry techniques. ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2020 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Lívia Gurgel do Amaral Valente Sá, Lara Elloyse Almeida Moreira, João Batista de Andrade Neto, Cecília Rocha da Silva, Manoel Odorico de Moraes, Jacilene Silva, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Érica Rayanne Mota da Costa, Maria Janielly Castelo Branco Silveira, Larissa Holanda e Silva, Hélio Vitoriano Nobre Júnior,
Candida spp. infections are a serious health problem, especially in patients with risk factors. The acquisition of resistance, often associated with biofilm production, makes treatment more difficult due to the reduced effectiveness of available antifungals. Drug repurposing is a good alternative for the treatment of infections by Candida spp. biofilms. The present study evaluated the in vitro antibiofilm activity of sertraline in reducing the cell viability of forming and matured biofilms, in addition ...
Tópico(s): Antimicrobial Peptides and Activities
2023 - Microbiology Society | Journal of Medical Microbiology
Produção Nacional
Revisado por pares
Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Fátima Daiana Dias Barroso, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lisandra Juvêncio da Silva, Iri Sandro Pampolha Lima, Lourdes Pérez, Anderson Ramos da Silva, Denise Ramos Moreira, Nágila Maria Pontes Silva Ricardo, Hélio Vitoriano Nobre Júnior,
Dual-species biofilms formed by Candida albicans and Staphylococcus aureus have high virulence and drug resistance. In this context, biosurfactants produced by Pseudomonas aeruginosa have been widely studied, of which a new derivative (RLmix_Arg) stands out for possible application in formulations. The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant ...
Tópico(s): Antibiotic Resistance in Bacteria
2024 - Taylor & Francis | Biofouling
Produção Nacional
Revisado por pares
João Batista de Andrade Neto, Vitória Pessoa de Farias Cabral, Lavouisier Frankilin Brito Nogueira, Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, Anderson Ramos da Silva, Wildson Max Barbosa da Silva, Jacilene Silva, Emmanuel Silva Marinho, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
Staphylococcus aureus is a commensal bacterium and opportunistic human pathogen that can cause a wide variety of clinical infections. It is recognized for its ability to acquire antimicrobial resistance, so methicillin-resistant Staphylococcus aureus (MRSA) infections are a global healthcare challenge. Therefore, the development of new therapeutic options and alternative therapies for treatment is necessary. Curcumin, a polyphenolic substance found in the rhizome of turmeric longa L, has been shown ...
Tópico(s): Oral microbiology and periodontitis research
2021 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Lara Elloyse Almeida Moreira, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Amanda Dias Barbosa, Maria Janielly Castelo Branco Silveira, Tatiana do Nascimento Paiva Coutinho, Sarah Alves Barbosa, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Sânia Nara Costa da Rocha, Celina Santos Reis, Bruno C. Cavalcanti, Maria Erivanda França Rios, Manoel O. de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva,
Tópico(s): Fungal Infections and Studies
2024 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Francisca Bruna Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Lisandra Juvêncio da Silva, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Camille R Braga Vasconcelos, Bruno C. Cavalcanti, Maria Erivanda França Rios, Jacilene Silva, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Jacó RL de Mesquita, Marina Duarte Pinto Lobo, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva,
Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. Materials & methods: The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms. With regard to action mechanisms, the authors evaluated cell viability, DNA damage and molecular docking. Results: MIC and minimum bactericidal concentration values ranged from 128 to 2048 μg/ml. There was synergism with oxacillin ( ...
Tópico(s): Cancer therapeutics and mechanisms
2024 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Francisca Bruna Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Letícia Serpa Sampaio Moreno, Helaine Almeida Queiroz, Lisandra Juvêncio da Silva, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Sidnei Samuel Pereira, Bruno C. Cavalcanti, Jacilene Silva, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva,
Objective: To evaluate the antifungal activity of hydralazine hydrochloride alone and in synergy with azoles against Candida spp. and the action mechanism. Methods: We used broth microdilution assays to determine the MIC, checkerboard assays to investigate synergism, and flow cytometry and molecular docking tests to ascertain action mechanism. Results: Hydralazine alone had antifungal activity in the range of 16-128 μg/ml and synergistic effect with itraconazole versus 100% of the fungal isolates, ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2023 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Amanda Dias Barbosa, Lívia Gurgel do Amaral Valente Sá, João BA Neto, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Lara Elloyse Almeida Moreira, Igor Aguiar, Hélcio Silva dos Santos, Bruno C. Cavalcanti, Emmanuel Silva Marinho, Jacilene Silva, Hemerson Iury Ferreira Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva,
Aim: This study was designed to evaluate the in vitro antimicrobial activity of amlodipine against Staphylococcus aureus strains. Materials & methods: The antimicrobial activity of amlodipine was evaluated by the broth microdilution method and its interaction with oxacillin was evaluated by checkerboard assay. The possible mechanism of action was evaluated by flow cytometry and molecular docking techniques. Results: Amlodipine showed activity against S. aureus between 64 and 128 μg/ml, in addition ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2023 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João BA Neto, Jacilene Silva, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
To evaluate the antibacterial activity of paroxetine alone and associated with oxacillin against isolates of methicillin-sensitive and -resistant
Tópico(s): Cancer therapeutics and mechanisms
2023 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Lisandra Juvêncio da Silva, Fátima Daiana Dias Barroso, Lucas Sousa Vieira, Daniel Roberto Carlos Mota, Bruna Kelly da Silva Firmino, Cecília Rocha da Silva, Vitória Pessoa de Farias Cabral, Thiago M Cândido, Lívia Gurgel do Amaral Valente Sá, Wildson Max Barbosa da Silva, Jacilene Silva, Emmanuel Silva Marinho, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, João Batista de Andrade Neto,
The genus Candida spp. has been highlighted as one of the main etiological agents causing fungal infections, with Candida albicans being the most prominent, responsible for most cases of candidemia. Due to its capacity for invasion and tissue adhesion, it is associated with the formation of biofilms, mainly in the environment and hospital devices, decreasing the effectiveness of available treatments. The repositioning of drugs, which is characterized by the use of drugs already on the market for ...
Tópico(s): Bacterial biofilms and quorum sensing
2021 - Microbiology Society | Journal of Medical Microbiology
Produção Nacional
Revisado por pares
João Batista de Andrade Neto, Maria Aparecida Alexandre Josino, Cecília Rocha da Silva, Rosana de Sousa Campos, Francisca Bruna Stefany Aires do Nascimento, Sandro Serpa, Lívia Gurgel do Amaral Valente Sá, Igor de Sá Carneiro, Fátima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Jacó Ricarte Lima de Mesquita, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
Emergence of methicilin resistant Staphylococcus aureus (MRSA) strains is a major cause of infirmity worldwide and has limited our therapeutic options against these pathogens. In this regard, the search for candidates with an antimicrobial activity, with a greater efficacy and a lower toxicity, is necessary. As a result, there is greater need to search for resistance modifying agents which, in combination with existing drugs, will restore the efficacy of these drugs. The antibacterial effect of fluoxetine ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2018 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Marcos Takashi Obara, José Maria Soares Barata, João Aristeu da Rosa, Walter Ceretti, Paulo Silva de Almeida, GUILMARA DO AMARAL GONÇALVES, Carolina Dale, Rodrigo Gurgel‐Gonçalves,
Triatoma baratai Carcavallo & Jurberg, 2000, a species similar to Triatoma williami Galvão, Souza & Lima, 1967 andbelonging to the T. matogrossensis subcomplex, was described based on a male specimen collected in a sylvatic environ-ment, near a cave, in Bonito county, Bodoquena mountain range, state of Mato Grosso do Sul, Brazil. In the present workwe describe the female of T. baratai, captured in a chicken house, in Nioaque county, state of Mato Grosso do Sul, Brazil.Furthermore, we recorded the occurrence ...
Tópico(s): Insect-Plant Interactions and Control
2012 - Q15088586 | Zootaxa
Produção Nacional
Revisado por pares
Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, Lara Elloyse Almeida Moreira, João BA Neto, Jacilene Silva, Hélcio Silva dos Santos, Emmanuel Silva Marinho, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
Aim: Our study evaluated the activity of sertraline (SER) alone and associated with antifungal drugs in planktonic Candida spp. strains, and investigated its mechanism of action. Materials & methods: Broth microdilution method and minimum fungicidal concentration/MIC ratio were used to assess SER anticandidal activity, and the interaction with antifungals was determined by fractional inhibitory concentration index. The mechanism of action was investigated by flow cytometry and in silico tests. Results: ...
Tópico(s): Fungal Plant Pathogen Control
2023 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Letícia Serpa Sampaio Moreno, Francisca Bsa Nascimento, Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, João B A de Neto, Jacilene Silva, Emmanuel M Silva, Hélcio Silva dos Santos, Lourdes Pérez, A. R. Da Silva, Daniel Sampaio Rodrigues, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Bruno C. Cavalcanti, Manoel Odorico de Morais, Hélio Vitoriano Nobre Júnior,
Aims: This study aimed to evaluate the antibacterial effect of two new cationic surfactants based on phenylalanine-arginine (LPAM) and tryptophan-arginine (LTAM). Materials & methods: Antibacterial activity, mechanism of action and interactions with Staphylococcus aureus enzymes were measured through microbiological, flow cytometry and molecular docking assays, respectively. Results & conclusion: These compounds showed antibacterial activity in the range of 4.06–16.24 μg/ml against planktonic cells and ...
Tópico(s): Biopolymer Synthesis and Applications
2022 - Future Medicine | Future Microbiology
Produção Nacional
Joyce Pereira Arantes, Marcos Vinicius Holanda Bessa, Adalzira Andreina Cavalcanti de Miranda Coelho, Mariana Abrantes Maciel Bonifácio, Manuela Figueira Viégas Borges, Brunna Ferreira Fábio, Amanda Zamuner Wosiack, Sanny Selma Ferreira Custódio, Hiany Bacelete Tavares, Jacson Gomes de Oliveira Júnior, Maria Luiza Megale Brandão Gurgel do Amaral, João Vinicius Santos Lima, Jorge Brian Cavalcante Portela de Almeida, David Flores Gutierrez, Jessé Alves da Cunha,
A Doença Inflamatória Pélvica (DIP) é uma condição grave que afeta a saúde reprodutiva feminina, podendo levar à infertilidade e outras complicações. Este estudo teve como objetivo revisar a literatura recente sobre o tratamento da DIP, buscando avaliar as abordagens terapêuticas mais eficazes e seguras. A metodologia utilizada foi uma revisão integrativa, conduzida em julho de 2024, nas bases de dados Scientific Electronic Library Online (SCIELO) e Literatura Latino-Americana e do Caribe em Ciências ...
Tópico(s): Reproductive System and Pregnancy
2024 - | Brazilian Journal of Implantology and Health Sciences
Produção Nacional
Revisado por pares
Bruno C. Cavalcanti, João Batista de Andrade Neto, Antônio Adailson de Sousa Silva, Francisco Stefânio Barreto, José Roberto de Oliveira Ferreira, Cecília Rocha da Silva, Francisca Bruna Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, Hemerson Iury Ferreira Magalhães, Hélio Vitoriano Nobre Júnior, Manoel Odorico de Moraes,
Ketamine is a potent uncompetitive NMDA receptor antagonist that provides amnesia, analgesia, environmental dissociation and immobility, where it has its cytotoxic effect well described in the literature. However, the work on its genotoxic/mutagenic potentials are scarce and insufficient and does not allow a reasonable evaluation of its role. Thus, in the present work, we decided to evaluate the genotoxic and mutagenic effects of ketamine on human peripheral blood leukocytes (PBLs) and Salmonella ...
Tópico(s): Anesthesia and Sedative Agents
2019 - Elsevier BV | Toxicology in Vitro
Produção Nacional
Revisado por pares
Wanderson Luis da Silva e Silva, Mônica Falcão da Silva, Dário Dantas do Amaral, Maria De Nazaré Lima Do Carmo, Ely Simone Cajueiro Gurgel, João Ubiratan Moreira dos Santos,
Abstract Pará state has one of the longest coastal in Brazil. However, floristic surveys have been conducted in few regions and only one study has comprehensively evaluated the coastal flora of the state. The objective of this study was to create an updated and certified checklist of the angiosperms in the restingas of Pará. The list was made using literature, floristic and taxonomic revisions, herbaria specimens from HBRA, IAN, MFS and MG, and collections made between 2014 and 2018. Overall, 470 ...
Tópico(s): Fern and Epiphyte Biology
2021 - Rio de Janeiro Botanical Garden Research Institute | Rodriguésia
Produção Nacional
Revisado por pares
Lisandra Juvêncio da Silva, Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, Fátima DD Barroso, Thiago M Cândido, Helaine Almeida Queiroz, Lara Elloyse Almeida Moreira, Octavio V Baccallini, Bruno C. Cavalcanti, Jacilene Silva, Emmanuel Silva Marinho, Manoel Odorico de Moraes, João B A de Neto, Hélio Vitoriano Nobre Júnior,
Objective: The present study investigated the antifungal action of dexamethasone disodium phosphate (Dex). Methodology: Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol; M27-A3, checkerboard test and biofilm were evaluated with two isolates of Candida albicans, hyphal production test, molecular docking analysis and flow cytometry analysis. Result: Dex and fluconazole (FLC) together had a synergistic effect. Mature biofilm was reduced when treated with ...
Tópico(s): Oral microbiology and periodontitis research
2022 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Caio Bezerra Machado, Cecília Rocha da Silva, Fátima Daiana Dias Barroso, Rosana de Sousa Campos, Lívia Gurgel do Amaral Valente Sá, Francisca Bruna Stefany Aires do Nascimento, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior, João Batista de Andrade Neto,
Candida spp. is considered to be the third or fourth most common cause of bloodstream infections associated with healthcare services in the world. Currently, several strains exhibit resistance to the traditional treatments, making the development of new therapeutic molecules necessary. Drug repositioning is an alternative that can be used to work around problems such as toxicity, cost and time in the development of new drugs. This study aims to evaluate the in vitro antifungal effect of tropicamide, ...
Tópico(s): Antibiotic Use and Resistance
2020 - Elsevier BV | Journal de Mycologie Médicale
Produção Nacional
Revisado por pares
Fátima DD Barroso, Lisandra J da Silva, Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João B A de Neto, Francisca BA do Nascimento, Helaine Almeida Queiroz, Amanda C Leitão, Vitória PF Cabral, Daniel Sampaio Rodrigues, Amanda Dias Barbosa, Bruno C. Cavalcanti, Manoel Odorico de Morais, Hélio Vitoriano Nobre Júnior,
Aims: To evaluate the antifungal effect of dobutamine against Candida glabrata as well as its synergism with azoles and its action on biofilm. Methods: The M27-A3 protocol and flow cytometry were used for elucidation of the possible mechanism of action. Results: The tested isolates presented MICs ranging from 2 to 32 μg/ml for dobutamine, with fungistatic effect. A total of 82% of the strains showed synergism with fluconazole, with 90% showing synergism with itraconazole. The effect on biofilm formation ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2022 - Future Medicine | Future Microbiology