Michael Haap, Andreas Fritsche, Heinz Joachim Mensing, Hans-Ulrich H�ring, Michael Stümvoll,
... Insulin Resistance in Healthy PeopleMichael Haap, MD, Andreas Fritsche, MD, Heinz Joachim Mensing, MD, Hans-Ulrich Hring, MD, and Michael ... University of Tbingen; D-72076 Tbingen, Germany., Andreas Fritsche, MDFrom University of Tbingen; D-72076 Tbingen, Germany., Heinz Joachim Mensing, MDFrom University of Tbingen; D-72076 Tbingen, ...
Tópico(s): Folate and B Vitamins Research
2003 - American College of Physicians | Annals of Internal Medicine
X Wang, Haro Fritsche, Oliver Lux, Hans Joachim Eichler, Zhongquan Zhao, Casey Schuett, Bastian Kruschke,
A pulsed Er:YAG laser with resonant in-band diode pumping was demonstrated. Laser pulses with 6.6 mJ energy and 50 ns pulse duration were generated. With an intra-cavity etalon a broad wavelength tuning range from 1643.47 to 1646.78 nm was obtained. A stable dual-wavelength operation was observed by fine tuning of the etalons. The separation of the two wavelengths was 0.78 nm. One of them was located within a methane absorption line and the other was off the line. The frequency stability of the ...
Tópico(s): Laser Design and Applications
2013 - IOP Publishing | Laser Physics Letters
Mirjana Kessler, Karen Hoffmann, Kristin Fritsche, Volker Brinkmann, Hans‐Joachim Mollenkopf, Oliver Thieck, Ana Rita Teixeira da Costa, Elena Ioana Braicu, Jalid Sehouli, Mandy Mangler, Hilmar Berger, Thomas F. Meyer,
Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr serovars D, K and E for long-term in vitro analysis. The epithelial monolayer responds with active expulsion of the bacteria into the lumen and with compensatory cellular proliferation-demonstrating a role of epithelial homeostasis in the defense against this pathogen. In addition, Ctr infection activates LIF signaling, which ...
Tópico(s): Reproductive System and Pregnancy
2019 - Nature Portfolio | Nature Communications
Ulrich Gergs, Julia Fritsche, Stephanie Fabian, Josepha Christ, Joachim Neumann,
Tópico(s): Cardiac electrophysiology and arrhythmias
2017 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Raphael F. Fritsche, Gabriele Theumer, Olga Kataeva, Hans‐Joachim Knölker,
Abstract We describe iron‐catalyzed intermolecular oxidative coupling reactions of diarylamines to form substituted 2,2′‐bis(arylamino)biaryl compounds, tetraarylhydrazines, and 5,6‐dihydrobenzo[ c ]cinnolines with the same hexadecafluorinated iron–phthalocyanine catalyst. The mild formation of C−C or N−N bonds was controlled by the use of acidic or basic additives. In contrast to most iron‐catalyzed dehydrogenative coupling reactions, ambient air could be used as the sole oxidant. Moreover, iron( ...
Tópico(s): Radical Photochemical Reactions
2016 - Wiley | Angewandte Chemie
Raphael F. Fritsche, Gabriele Theumer, Olga Kataeva, Hans‐Joachim Knölker,
We describe iron-catalyzed intermolecular oxidative coupling reactions of diarylamines to form substituted 2,2'-bis(arylamino)biaryl compounds, tetraarylhydrazines, and 5,6-dihydrobenzo[c]cinnolines with the same hexadecafluorinated iron-phthalocyanine catalyst. The mild formation of C-C or N-N bonds was controlled by the use of acidic or basic additives. In contrast to most iron-catalyzed dehydrogenative coupling reactions, ambient air could be used as the sole oxidant. Moreover, iron(III) chloride ...
Tópico(s): Radical Photochemical Reactions
2016 - Wiley | Angewandte Chemie International Edition
Arne Melander, Jonny Olsson, Gunnar Lindberg, Alice Salzman, Timothy G. Howard, Paul Stang, Eva Lydick, Alistair Emslie‐Smith, D. I. R. Boyle, JEFF EVANS, Tamara MacDonald, Jennifer Bain, Frank Sullivan, Christian R. Juhl, Niels Pörksen, Jeppe Sturis, Malene Hollingdal, Steven M. Pincus, Johannes D. Veldhuis, A. Dejgaard, O. Schmitz, J. S. Kristensen, Kirstine Brown Frandsen, Thomas Bayer, Paul Müller, Beth E. Dunning, Sara Paladini, C. Gutierrez, Rachel Deacon, M. Valentin, George Grunberger, Wayde M. Weston, Rita Patwardhan, Elizabeth B. Rappaport, L. A. Sargeant, Nicholas J. Wareham, K.-T. Khaw, Björn Zethelius, Hans Lithell, C. N. Hales, Christian Berne, Hanna-Maaria Lakka, Laura Oksanen, T.-P. Tuomainen, Kimmo Kontula, J T Salonen, J. M. Dekker, P. de Boks, Femmie de Vegt, Coen D.A. Stehouwer, G. Nijpels, L.M. Bouter, R. J. Heine, Giovanni Bruno, P. Cavallo‐Perin, G Bargero, Nicola D’Errico, M. Borra, G. Macchia, Gianfranco Pagano, R. Newton, Danny Ruta, John P. New, Chris Wallace, M Roxburgh, R. J. Young, N. J. A. Vaughan, Perry Elliott, G. Brennan, Marion Devers, R. MacAlpine, Doug Steinke, David H. Lawson, Brigitte Decallonne, Kristina Casteels, Conny Gysemans, R. Bouillon, Chantal Mathieu, Thomas Linn, Christine Strate, Kerstin Schneider, David P. Funda, M Jirsa, Hana Kozáková, Anne Kaas, Olga Kofroňová, Helena Tlaskalová-Hogenová, Karsten Buschard, Heike Wanka, Andreas Hartmann, Beate Kuttler, S. Rasmussen, T. S. Sørensen, Helle Markholst, J. S. Petersen, Dennis G. Karounos, Thomas Dyrberg, Jon G. Mabley, György Haskó, Csaba Szabó, Jochen Seißler, T. B. T. Nguyen, Holger Steinbrenner, Werner A. Scherbaum, R Cipriani, Annarita Gabriele, M. Sensi, Leo Guidobaldi, Federico Pantellini, Maria Grazia Cerrito, Stefano Scarpa, U. Di Mario, Susanna Morano, G. Ceolotto, E. Iori, Elisabetta Baritono, S. Del Prato, Andrea Semplicini, Roberto Trevisan, Gianpaolo Zerbini, Giancarla Meregalli, Veronica Asnaghi, F. Tentori, Anna Maestroni, Ruggero Mangili, C. Marescotti, Monica Vedovato, Antonio Tiengo, J. Tadjieva, Boris Mankovsky, Sara Van Aken, Ann Raes, Johan Vande Walle, Dominique Matthys, Margarita Craen, Henrik Post Hansen, S. S. Lund, Peter Rossing, Thomas Bo Jensen, H.-H. Parving, S. Andersen, Lise Tarnow, B. V. Hansen, Christoph Trautner, Burkhard Haastert, N. Ennenbach, Stefan N. Willich, Ádám G. Tabák, T. J. Orchard, J Spranger, Klaus T. Preissner, H. Schatz, A. Pfeiffer, Alberto Palmero Canton, R Burgos, Cristina Hernández, Albert Lecube, Juan Esteban Gómez‐Mesa, Rosa Segura, Calvo Mateo, Rafael Simó, Lamia Fathallah, D. A. Greene, Irina G. Obrosova, R Gilbert, Dominique Kelly, Alison J. Cox, J. L. Berka-Wilkinson, Hugh R. Taylor, Sianna Panagiotopoulos, Vivian Lee, G. Jerums, Maria Cooper, G. A. Hitman, E Aganna, W Ogunkolade, M. Rema, R Deepa, C S Shanthirani, Khaled Barakat, Thisum R. Kumarajeewa, Paul G. Cassell, Michael McDermott, Viswanathan Mohan, Kirk Ways, Sven Bursell, Todd DeVries, James R. Woodworth, Carlos Alatorre, G. R. Gnana King, Lloyd Paul Aiello, A. E. Karisen, Dejan Pavlović, Kristina Tomra Nielsen, Jens‐Ulrik Stæhr Jensen, Henrik U. Andersen, Flemming Pociot, T. Mandrup-Poulsen, Décio L. Eizirik, J. Nerup, S Lortz, Markus Tiedge, Sigurd Lenzen, Frank Lally, Angie Bone, M. I. Darville, Ye‐Shih Ho, Johnny Sternesjö, S. Sandler, Ming‐Yin Chen, F. Schuit, Daniël Pipeleers, S. Merezak, Anandwardhan A. Hardikar, J. J. Hoet, Claude Remacle, Brigitte Reusens, B. Bréant, A. Garofano, P Czernichow, Naoto Kubota, Yasuo Terauchi, Hiroyuki Miki, Hiroyuki Tamemoto, T. Yamauchi, Reiji Nakano, Koji Komeda, Komyo Eto, Kazuyuki Tobe, S. Kimura, Takuya Kadowaki, Tatsuro Ide, Kazutoshi Murakami, Mamoru Tsunoda, T. Mochizuki, Susan E. Ozanne, B. Nave, Chung‐Li Wang, M. W. Dorling, Clive J. Petry, S.J. Koopmans, Chris van der Bent, Ivo Que, J.K. Radder, E Seböková, Aleeza Sana, I Klimeś, Neil B. Ruderman, L. Morviducci, Lisa M. Pastore, S. Morelli, Elisabetta Sagratella, D. Zorretta, A. Buongiomo, G Tamburrano, Andrea Giaccari, Sabina Martinenghi, Maria Gabriella Cusella De Angelis, F. Ravasi, Francesco Bifari, Claudio Bordignon, Luca Falqui, A Kessler, Olaf Dransfeld, Shlomo Sasson, E. Tomás, A. Zorzano, Jürgen Eckel, Per Medbøe Thorsby, A. Rosenfalck, Lise Kjems, K. F. Hanssen, Sten Madsbad, K. I. Birkeland, M. Hamilton-Wessler, J. Markussen, R. N. Bergman, V. Melki, H Hanaire-Broutin, S Bessières-Lacombe, J. Tauber, P. D. Home, Anna Lindholm Olinder, A. Riis, J Rosenstock, S. Schwartz, Christine M. Clark, Matthew Edwards, David Donley, Peter Swift, Henrik B. Mortensen, Helle Lynggaard, Philip Hougaard, C A Cull, H. A. W. Neil, V. Frighi,
Springer Science+Business Media
Fabian Springer, Jürgen Machann, Nina F. Schwenzer, Verena Ballweg, Christian Würslin, Joachim H. Schneider, Andreas Fritsche, Claus D. Claussen, Fritz Schick,
Objectives: The aim of this study was to evaluate the feasibility of 2 established magnetic resonance imaging based techniques to quantify intrahepatic lipids (IHL) within a study population of extremely obese patients by means of a short, wide-bore MR scanner. Fat-selective imaging using a spectral-spatial excitation technique and in-phase/opposed-phase (IN/OP) gradient echo imaging were applied and results were compared. Results for IN/OP technique were corrected for T1- and T2*- relaxation effects. ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2010 - Lippincott Williams & Wilkins | Investigative Radiology
Raphael F. Fritsche, Tristan Schuh, Olga Kataeva, Hans‐Joachim Knölker,
We describe an iron-catalyzed asymmetric oxidative C-C coupling of diarylamines which proceeds at room temperature with air as final oxidant. Using hexadecafluorophthalocyanine-iron(II) as catalyst in the presence of catalytic amounts of an axially chiral biaryl phosphoric acid, the resulting chiral 2,2'-diamino-1,1'-biaryls are obtained in up to 90 % ee as confirmed by chiral HPLC. A detailed mechanism has been proposed with a radical cation-chiral phosphate ion pair as key intermediate leading to ...
Tópico(s): Molecular spectroscopy and chirality
2022 - Wiley | Chemistry - A European Journal
Haro Fritsche, Oliver Lux, Xia-Chun Wang, Zhongquan Zhao, Hans Joachim Eichler,
We report on the development of compact and frequency-stable Er:YAG laser systems emitting in the eye-safe spectral region. Resonant cw diode pumping provides 4.5 W output power in cw operation and 2.2 mJ in Q-switched operation with pulse duration of about 140 ns. The application of intra-cavity etalons allows for wavelength tuning from 1645.22 to 1646.33 nm while the frequency stability accounts for less than 50 MHz. The potential of the erbium laser sources in terms of methane detection was evaluated ...
Tópico(s): Atmospheric Ozone and Climate
2013 - IOP Publishing | Laser Physics Letters
Fabian Springer, Manuel Schwarz, Jürgen Machann, Andreas Fritsche, Claus D. Claussen, Fritz Schick, Joachim H. Schneider,
Tópico(s): Cardiovascular Disease and Adiposity
2010 - Springer Science+Business Media | Obesity Surgery
Oliver Lux, Haro Fritsche, Hans Joachim Eichler,
Abstract Active remote sensing represents a promising technology to accurately measure the atmospheric concentration of the climate‐relevant trace gases carbon dioxide and methane. For this application, frequency stabilized laser sources with high pulse energy emitting at specific absorption lines around 1.6 μm wavelength are required. While Raman frequency conversion of high power solid‐state laser systems provides sources suitable for CO 2 detection, compact resonantly pumped Er:YAG lasers are ...
Tópico(s): Laser Design and Applications
2013 - Wiley | Optik & Photonik
Hans J. Schramm, Joachim Boetzel, J. Büttner, Erich Fritsche, Walter Göhring, E Jaeger, Stephan König, Jörg Oliver Thumfart, Traudl Wenger, N. Nagel,
The active human immuondeficiency virus type 1 (HIV-1) protease has a homodimeric structure, the subunits are connected by an ‘interface’ β-sheet formed by the NH2- and COOH-terminal amino acid segments. Short peptides derived from these segments are able to inhibit the protease activity in the range of micromolar IC50 values. We have further improved the inhibitory power of such peptides by computer modelling. The best inhibitor, the palmitoyl-blocked peptide Pam-Thr-Val-Ser-Tyr-Glu-Leu, has an IC50 ...
Tópico(s): Click Chemistry and Applications
1996 - Elsevier BV | Antiviral Research
Joachim Langstein, Jan Michel, Jana Fritsche, Marina Kreutz, Reinhard Andreesen, Herbert Schwarz,
CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor. CD137 protein induces expression of IL-6, IL-8, and TNF-alpha, and inhibits expression of IL-10. Furthermore, CD137 differentially regulates expression of cell surface receptors. It induces expression of ICAM and reduces expression of FcgammaRIII, while levels of HLA-DR remain ...
Tópico(s): Antimicrobial Peptides and Activities
1998 - American Association of Immunologists | The Journal of Immunology
Sebastian Boland, Ulrike Schmidt, Vyacheslav Zagoriy, Júlio L. Sampaio, Raphael F. Fritsche, Regina Czerwonka, Tilo Lübken, Jakob Reimann, Sider Penkov, Hans‐Joachim Knölker, Teymuras V. Kurzchalia,
Tópico(s): Lipid metabolism and biosynthesis
2017 - Nature Portfolio | Nature Chemical Biology
Christian Brütting, Raphael F. Fritsche, Sebastian K. Kutz, Carsten Börger, Arndt W. Schmidt, Olga Kataeva, Hans‐Joachim Knölker,
Abstract We describe the synthesis of 1,1′‐ and 2,2′‐bicarbazoles by oxidative homocoupling of 2‐ and 1‐hydroxycarbazoles. The oxidative coupling using catalytic amounts of F 16 PcFe can be applied to both groups of substrates. Although F 16 PcFe generally provides the best yields for the synthesis of 1,1′‐bicarbazoles, di‐ tert ‐butyl peroxide affords better results for the 2,2′‐bicarbazoles. In our study, we have achieved the first syntheses of the biscarbalexines A–C, bisglybomine B, 2,2′‐dihydroxy‐ ...
Tópico(s): Alkaloids: synthesis and pharmacology
2017 - Wiley | Chemistry - A European Journal
Vladimír Novotný, Michael Froehner, Matthias May, Chris Protzel, Katrin Hergenröther, Michael Rink, Felix K.‐H. Chun, Margit Fisch, Florian Roghmann, Rein‐Jüri Palisaar, Joachim Noldus, Michael Gierth, Hans‐Martin Fritsche, Maximilian Burger, Danijel Sikic, Bastian Keck, Bernd Wullich, Philipp Nuhn, Alexander Büchner, Christian G. Stief, Stefan Vallo, Georg Bartsch, Axel Haferkamp, Patrick J. Bastian, Oliver W. Hakenberg, Stefan Propping, Atiqullah Aziz,
Tópico(s): Urological Disorders and Treatments
2015 - Springer Science+Business Media | World Journal of Urology
H. Wilman, Constantinos A. Parisinos, Naeimeh Atabaki‐Pasdar, Matt Kelly, E. Louise Thomas, Stefan Neubauer, Anubha Mahajan, Aroon D. Hingorani, Riyaz Patel, Harry Hemingway, Paul W. Franks, Jimmy D. Bell, Rajarshi Banerjee, Hanieh Yaghootkar, Christopher Jennison, Beate Ehrhardt, Patrick Baum, Corinna Schoelsch, Jan Freijer, Rolf Grempler, Ulrike Graefe‐Mody, Anita M. Hennige, Christiane Dings, Thorsten Lehr, Nina Scherer, Iryna Sihinecich, François Pattou, Violeta Raverdi, Robert Caïazzo, F. Torres, Hélène Verkindt, Andrea Mari, Andrea Tura, Toni Giorgino, Roberto Bizzotto, Philippe Froguel, Amelie Bonneford, Mickaël Canouil, Véronique Dhennin, Caroline Brorsson, Søren Brunak, Federico De Masi, Valborg Guðmundsdóttir, Helle K. Pedersen, Karina Banasik, Cecilia Engel Thomas, Peter Wad Sackett, Hans‐Henrik Stærfeldt, Agnete Troen Lundgaard, Birgitte Nilsson, Agnes Nielsen, Gianluca Mazzoni, Tugce Karaderi, Simon Rasmussen, Joachim Johansen, Rosa Lundbye Allesøe, Andreas Fritsche, Barbara Thorand, Jerzy Adamski, Harald Grallert, Mark Haid, Sapna Sharma, Martina Troll, Jonathan Adam, Jorge Ferrer, Heather Eriksen, Gary Frost, Ragna S. Häussler, Mun‐Gwan Hong, Jochen M. Schwenk, Mathias Uhlén, Claudia Nicolay, Imre Pávó, Birgit Steckel-Hamann, Melissa K. Thomas, Kofi Adragni, Han Wu, Leen't Hart, Slieker Roderick, Nienke van Leeuwen, Koen F. Dekkers, Francesca Frau, Johann Gassenhuber, Bernd Jablonka, Petra Musholt, Hartmut Ruetten, J. Tillner, Tania Baltauss, Oana Bernard Poenaru, Nathalie de Préville, Marianne Rodriquez, Manimozhiyan Arumugam, Kristine H. Allin, Line Engelbrechtsen, Torben Hansen, Tue H. Hansen, Annemette Forman, Anna Jonsson, Oluf Pedersen, Avirup Dutta, Josef Korbinian Vogt, Henrik Vestergaard, Markku Laakso, Tarja Kokkola, Teemu Kuulasmaa, Paul W. Franks, Nick N. Giordano, Hugo Pomares‐Millan, Hugo Fitipaldi, Pascal M. Mutie, Maria Klintenberg, Margit Bergstrom, Per‐Henrik Groop, Martin Ridderstråle, Naeimeh Atabaki Pasdar, Harshal Deshmukh, Alison Heggie, Dianne Wake, Donna McEvoy, Ian McVittie, Mark Walker, Andrew T. Hattersley, Anita Hill, Angus G. Jones, Timothy J. McDonald, Mandy H. Perry, Rachel Nice, Michelle Hudson, Claire E. Thorne, Emmanouil T. Dermitzakis, Ana Viñuela, Louise Cabrelli, Heather Loftus, Adem Y. Dawed, Louise A. Donnelly, Ian Forgie, Ewan R. Pearson, Nicholette D. Palmer, Andrew Brown, Robert W. Koivula, Agata Wesolowska‐Andersen, Moustafa Abdalla, Nicky McRobert, Juan Fernandez, Yunlong Jiao, Neil Robertson, Stephen Gough, Jane Kaye, Miranda Mourby, Anubha Mahajan, Mark I. McCarthy, Nisha Shah, Harriet Teare, Reinhard W. Holl, Anitra D.M. Koopman, Femke Rutters, Joline W. J. Beulens, Lenka Groeneveld, Anitra D.M. Koopman, Jimmy D. Bell, E. Louise Thomas, Brandon Whitcher,
Excess liver iron content is common and is linked to the risk of hepatic and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content and use genetics to understand its link to other traits and diseases.
Tópico(s): Folate and B Vitamins Research
2019 - Elsevier BV | Journal of Hepatology
Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson, Robert W. Koivula, Petra J. M. Elders, Simone P. Rauh, Angus G. Jones, Reinhard W. Holl, Julia C. Stingl, Paul W. Franks, Mark I. McCarthy, Leen M. ‘t Hart, Ewan R. Pearson, Christopher Jennison, Beate Ehrhardt, Patrick Baum, Corinna Schoelsch, Jan Freijer, Rolf Grempler, Ulrike Graefe‐Mody, Anita M. Hennige, Christiane Dings, Thorsten Lehr, N. Scherer, Iryna Sihinecich, François Pattou, V. Raverdi, Robert Caïazzo, F. Torres, Hélène Verkindt, Andrea Mari, Andrea Tura, Toni Giorgino, Roberto Bizzotto, Philippe Froguel, Amelie Bonneford, Mickaël Canouil, Véronique Dhennin, Caroline Brorsson, Søren Brunak, Francesco De Masi, Vilborg Guðmundsdóttir, Hans Kristian Pedersen, K. Banasik, E. S. Thomas, Walter G. Sackett, Hans‐Henrik Stærfeldt, Agnete Troen Lundgaard, Birgitte Nilsson, Nielsen Am, Gianluca Mazzoni, Tugce Karaderi, Simon Rasmussen, Joachim Johansen, Rosa Lundbye Allesøe, A. Fritsche, Barbara Thorand, Jerzy Adamski, H. Grallert, Mark Haid, Sapna Sharma, Mark Troll, Jean‐Michel Adam, Jorge Ferrer, Philippe Froguel, R.G. Eriksen, Gary Frost, Ragna S. Häussler, Mun‐Gwan Hong, Jochen M. Schwenk, Mathias Uhlén, CLAUDIA NICOLAY, Imre Pávó, Birgit Steckel-Hamann, Melissa K. Thomas, Kofi P. Adragni, Huihai Wu, Leen M. ‘t Hart, Ryland Roderick, Nienke van Leeuwen, Koen F. Dekkers, Francesca Frau, Johann Gassenhuber, Bernd Jablonka, PB Musholt, Hartmut Ruetten, J. Tillner, Tania Baltauss, Olivier Bernard, N. Poenaru, Michel Préville, M. Rodriquez, Kumar Arumugam, Leslie Allin, T. Engelbrechtsen, Tue H. Hansen, Anne-Louise S. Hansen, Axel Forman, Olof Jonsson, Anette Fischer Pedersen, JK Dutta, H.‐J. Vogt, Mogens Vestergaard, Teemu Laakso, Tarja Kokkola, P.W. Kuulasmaa, G.N. Franks, Heidi Giordano, Hugo Pomares‐Millan, P. Fitipaldi, M. Mutie, Maria Klintenberg, Lea Bergström, M. Groop, N. Ridderstrale, Homayoon Pasdar, Abhishek Deshmukh, D. Heggie, Deborah J. Wake, I. McEvoy, M. McVittie, A.T. Walker, Andrew T. Hattersley, Andrew G. Hill, T.J. Jones, Timothy J. McDonald, Roger R Perry, Marvin Nice, Charles E. Hudson, E. Tom Thorne, A. Dermitzakis, Laura Viñuela, H. Cabrelli, Alison Loftus, L. Dawed, Iona Donnelly, E.R. Forgie, C.N. Pearson, A.A. Palmer, R. W. Brown, Anu Koivula, M. Wesolowska-Andersen, Nabil Abdalla, J. McRobert, J. Fernandez, Michael Kaye, A. Mourby, M.I. Mahajan, Nina S. McCarthy, Hetal Shah, Y. Teare, Ning Jiao, S. Robertson, Rachel Gough, A.D. Holl, Frieda A. Koopman, J.W. Rutters, L. Beulens, A.D. Groeneveld, J.D. Koopman, Eric L. Bell, Thomas, Brandon Whitcher,
Gastrointestinal adverse effects occur in 20-30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5-10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transporter 1 (OCT1) could increase the risk of severe gastrointestinal adverse effects.The study included 286 severe metformin- ...
Tópico(s): Pancreatic function and diabetes
2019 - American Diabetes Association | Diabetes Care
Malte W. Vetterlein, Philipp Gild, Luis A. Kluth, Thomas Seisen, Michael Gierth, Hans‐Martin Fritsche, Maximilian Burger, Chris Protzel, Oliver W. Hakenberg, Nicolas von Landenberg, Florian Roghmann, Joachim Noldus, Philipp Nuhn, Armin Pycha, Michael Rink, Felix K.‐H. Chun, Matthias May, Margit Fisch, Atiqullah Aziz,
Objectives To evaluate the effect of peri‐operative blood transfusion ( PBT ) on recurrence‐free survival, overall survival, cancer‐specific mortality and other‐cause mortality in patients undergoing radical cystectomy ( RC ), using a contemporary European multicentre cohort. Patients and Methods The Prospective Multicentre Radical Cystectomy Series ( PROMETRICS ) includes data on 679 patients who underwent RC at 18 European tertiary care centres in 2011. The association between PBT and oncological survival ...
Tópico(s): Urological Disorders and Treatments
2017 - Wiley | BJU International
Matthias May, Sabine Brookman‐May, Maximilian Burger, Christian Gilfrich, Hans‐Martin Fritsche, Michael Rink, Felix K.‐H. Chun, Margit Fisch, Florian Roghmann, Joachim Noldus, Roman Mayr, Armin Pycha, Vladimír Novotný, Manfred P. Wirth, Stefan Vallo, Axel Haferkamp, Jan Roigas, A. Brisuda, Regina Stredele, Björn Volkmer, Christopher Dechet, Marco J. Schnabel, Stefan Denzinger, Christian G. Stief, Patrick J. Bastian, Atiqullah Aziz,
Tópico(s): Urological Disorders and Treatments
2014 - Springer Science+Business Media | Annals of Surgical Oncology
Oliver Lux, Hanjo Rhee, Haro Fritsche, Hans Joachim Eichler,
Frequency conversion of a single longitudinal mode Nd:YAG laser operating at 1.064 μm is realized by an external third order Stokes barium nitrate Raman laser providing narrowband radiation at 1.599 μm wavelength which coincides with a CO 2 absorption line. Transmission measurements employing a multi-pass absorption cell yield good agreement with theoretical simulations of the CO 2 absorption characteristics.
Tópico(s): Laser Design and Applications
2013 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Andreas Fritsche, Frank Luethen, U. Lembke, Birgit Finke, C. Zietz, Joachim Rychly, Wolfram Mittelmeier, Rainer Bader,
Abstract The adhesion behaviour of osteoblastic cells on implant surfaces is a main focus during the development of osteoconductive implant surfaces. Therefore, besides cell spreading and proliferation on surfaces the adhesion strength of cells to the substrate is of high interest. There are different approaches to determine cell adhesion but only few quantitative methods. For this purpose, we have developed an adhesion device based on the spinning disc principle in conjunction with an inverse confocal ...
Tópico(s): Dental materials and restorations
2010 - Wiley | Materialwissenschaft und Werkstofftechnik
G. Schönhense, C. Westphal, Joachim Bansmann, M. Getzlaff, J. Noffke, L. Fritsche,
In angle-resolved photoelectron spectroscopy with circularly polarized radiation, the photoemission intensities depend on photon helicity. This phenomenon arises for pure electric dipole transitions and nonchiral species provided the target exhibits a spatial orientation (or alignment) and the experimental geometry defines a "handedness". The new type of spectroscopy is illustrated by the examples of photoemission from graphite (0001) and Pd(111) surfaces. It is evident that the effect does not result ...
Tópico(s): Electron and X-Ray Spectroscopy Techniques
1991 - Elsevier BV | Surface Science
Olga Pivovarova‐Ramich, Eva Fisher, Katarzyna Dudziak, Iryna Ilkavets, Steven Dooley, P. A. Slominsky, Limborskaia Sa, Martin O. Weickert, Joachim Spranger, Andreas Fritsche, Heiner Boeing, A. Pfeiffer, Natalia Rudovich,
Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancreatic fibrosis up-regulated in type 2 diabetes. In contrast, CTGF inactivation in mice compromises islet cell proliferation during embryogenesis. The aim of our study was to investigate an impact of CTGF ...
Tópico(s): Connective tissue disorders research
2011 - Hindawi Publishing Corporation | Disease Markers
Norbert Stefan, Cornelia Weikert, Joachim H. Ix, Andreas Fritsche, Hans‐Ulrich Häring,
In the article by Eraso et al. (1), circulating fetuin-A was lower in subjects with type 2 diabetes and an ankle brachial index (ABI) <0.9 compared with individuals with higher ABI. Furthermore, in an unadjusted model circulating fetuin-A correlated positively with ABI. It was concluded that low circulating fetuin-A may serve as a biomarker of peripheral arterial disease (PAD). This conclusion is only weakly supported by the data. It is very important to know that in the study by Eraso et al. (1), subjects ...
Tópico(s): Systemic Sclerosis and Related Diseases
2010 - American Diabetes Association | Diabetes Care
Matthias B. Schulze, Kurt Hoffmann, Heiner Boeing, Jakob Linseisen, Sabine Rohrmann, Matthias Möhlig, A. Pfeiffer, Joachim Spranger, Claus Thamer, Hans‐Ulrich Häring, Andreas Fritsche, Hans‐Georg Joost,
We aimed to develop a precise risk score for the screening of large populations for individuals at high risk of developing type 2 diabetes based on noninvasive measurements of major risk factors in German study populations.A prospective cohort study (European Prospective Investigation into Cancer and Nutrition [EPIC]-Potsdam study) of 9,729 men and 15,438 women aged 35-65 years was used to derive a risk score predicting incident type 2 diabetes. Multivariate Cox regression model coefficients were ...
Tópico(s): Diet and metabolism studies
2007 - American Diabetes Association | Diabetes Care
Atiqullah Aziz, Shahrokh F. Shariat, Florian Roghmann, Sabine Brookman‐May, Christian G. Stief, Michael Rink, Felix K.‐H. Chun, Margit Fisch, Vladimír Novotný, Michael Froehner, Manfred P. Wirth, Marco J. Schnabel, Hans‐Martin Fritsche, Maximilian Burger, Armin Pycha, A. Brisuda, Marko Babjuk, Stefan Vallo, Axel Haferkamp, Jan Roigas, Joachim Noldus, Regina Stredele, Björn Volkmer, Patrick J. Bastian, Évanguelos Xylinas, Matthias May,
Objective To externally validate the pT4a ‐specific risk model for cancer‐specific survival ( CSS ) proposed by M ay et al. ( Urol Oncol 2013; 31: 1141–1147) and to develop a new pT4a‐specific nomogram predicting CSS in an international multicentre cohort of patients undergoing radical cystectomy ( RC ) for urothelial carcinoma of the bladder ( UCB ) Patients and Methods Data from 856 patients with pT4a UCB treated with RC at 21 centres in E urope and N orth‐ A merica were assessed. The risk model proposed by ...
Tópico(s): Urological Disorders and Treatments
2014 - Wiley | BJU International
Malte W. Vetterlein, Christian P. Meyer, Sami‐Ramzi Leyh‐Bannurah, Roman Mayr, Michael Gierth, Hans‐Martin Fritsche, Maximilian Burger, Bastian Keck, Bernd Wullich, Thomas Martini, Christian Bolenz, Armin Pycha, Julian Hanske, Florian Roghmann, Joachim Noldus, Patrick J. Bastian, Christian Gilfrich, Matthias May, Michael Rink, Felix K.‐H. Chun, Roland Dahlem, Margit Fisch, Atiqullah Aziz, Georg Bartsch, Sabine Brookman‐May, Alexander Büchner, M. Durschnabel, Jörg Ellinger, Michael Froehner, Galia Georgieva, Murat Gördük, Marc‐Oliver Grimm, Boris Hadaschik, Axel Haferkamp, Oliver W. Hakenberg, Florian Hartmann, Edwin Herrmann, L. Hertle, Markus Hohenfellner, Georg Janetschek, Nicole Kraischits, Annerose Krausse, Lukas Lusuardi, Maurice Stephan Michel, Rudolf Moritz, Stefan Müller, Vladimír Novotný, Philipp Nuhn, Sascha Pahernik, Rein‐Jüri Palisaar, Anton Ponholzer, Chris Protzel, Jan Roigas, Marianne Schmid, Paul Schramek, C. Seitz, Danijel Sikic, Christian G. Stief, Isabella Syring, Stefan Vallo, Florian Wagenlehner, W. Weidner, Manfred P. Wirth,
Background Case volume has been suggested to affect surgical outcomes in different arrays of procedures. We aimed to delineate the relationship between case volume and surgical outcomes and quality of care criteria of radical cystectomy (RC) in a prospectively collected multicenter cohort. Patients and Methods This was a retrospective analysis of a prospectively collected European cohort of patients with bladder cancer treated with RC in 2011. We relied on 479 and 459 eligible patients with available ...
Tópico(s): Urological Disorders and Treatments
2017 - Elsevier BV | Clinical Genitourinary Cancer
Malte W. Vetterlein, Thomas Seisen, Matthias May, Philipp Nuhn, Michael Gierth, Roman Mayr, Hans‐Martin Fritsche, Maximilian Burger, Vladimír Novotný, Michael Froehner, Manfred P. Wirth, Chris Protzel, Oliver W. Hakenberg, Florian Roghmann, Rein‐Jüri Palisaar, Joachim Noldus, Armin Pycha, Patrick J. Bastian, Quoc‐Dien Trinh, Évanguelos Xylinas, Shahrokh F. Shariat, Michael Rink, Felix K.‐H. Chun, Roland Dahlem, Margit Fisch, Atiqullah Aziz,
Background The benefit of adjuvant chemotherapy (AC) for muscle-invasive urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC) is controversial. Objective To assess the effectiveness of AC after RC for muscle-invasive UCB in contemporary European routine practice. Design, setting, and participants By using a prospectively collected European multicenter database, we compared survival outcomes between patients who received AC versus observation after RC for locally advanced (pT3/T4) ...
Tópico(s): Urological Disorders and Treatments
2016 - Elsevier BV | European Urology Focus