Kate Bermingham, Inbar Linenberg, Lorenzo Polidori, Francesco Asnicar, Alberto Arrè, Jonathan Wolf, Fatema Badri, Hannah Bernard, Joan Capdevila Pujol, William J. Bulsiewicz, Christopher D. Gardner, José M. Ordovás, Richard Davies, George Hadjigeorgiou, Wendy L. Hall, Linda M. Delahanty, Ana M. Valdes, Nicola Segata, Tim D. Spector, Sarah Berry,
Large variability exists in people's responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health using a randomized clinical trial. The PDP used food characteristics, individual postprandial glucose and triglyceride (TG) responses to foods, microbiomes and health history, to produce personalized food scores in an 18-week app-based program. The control ...
Tópico(s): Nutritional Studies and Diet
2024 - Nature Portfolio | Nature Medicine
Joan Lecina, Òscar Palacios, Sı́lvia Atrian, Mercè Capdevila, Joan Suades,
Tópico(s): Boron Compounds in Chemistry
2014 - Springer Science+Business Media | JBIC Journal of Biological Inorganic Chemistry
Gloria Fackelmann, Paolo Manghi, Niccolò Carlino, Vitor Heidrich, Gianmarco Piccinno, Liviana Ricci, Elisa Piperni, Alberto Arrè, Elco Bakker, Alice Creedon, Lucy Francis, Joan Capdevila Pujol, Richard Davies, J. Jay Wolf, Kate Bermingham, Sarah Berry, Tim D. Spector, Francesco Asnicar, Nicola Segata,
Abstract As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little is known about diet-pattern-specific metagenomic profiles across populations. Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences in diet pattern (omnivore, vegetarian and vegan) are reflected in gut microbiomes. Microbial profiles distinguished these common diet patterns well (mean AUC = 0.85). Red meat was a strong driver ...
Tópico(s): Nutritional Studies and Diet
2025 - Nature Portfolio | Nature Microbiology
Anna Mas‐Capdevila, Joan Teichenne-Jané, Cristina Domenech-Coca, Antoni Caimari, Josep M Del Bas-Prior, Xavier Escoté, Anna Crescenti,
Recently, hesperidin, a flavonone mainly present in citrus fruits, has emerged as a new potential therapeutic agent able to modulate several cardiovascular diseases (CVDs) risk factors. Animal and in vitro studies demonstrate beneficial effects of hesperidin and its derived compounds on CVD risk factors. Thus, hesperidin has shown glucose-lowering and anti-inflammatory properties in diabetic models, dyslipidemia-, atherosclerosis-, and obesity-preventing effects in CVDs and obese models, and antihypertensive ...
Tópico(s): Moringa oleifera research and applications
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Javier Narváez, M. Ricse, Montserrat Gomà‐i‐Freixanet, Francesca Mitjavila, Xavier Fulladosa, Olga Capdevila, Joan Torrás, Xavier Juanola, Ramón Pujol-Farriols, Joan M. Nolla,
Whether a repeat renal biopsy is helpful during lupus nephritis (LN) flares remains debatable. In order to analyze the clinical utility of repeat renal biopsy in this complex situation, we retrospectively reviewed our series of 54 LN patients who had one or more repeat biopsies performed only on clinical indications. Additionally, we reviewed 686 well-documented similar cases previously reported (PubMed 1990–2015). The analysis of all patients reviewed showed that histological transformations are ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2017 - Wolters Kluwer | Medicine
Carmina Castellano‐Tejedor, Marta Pérez‐Campdepadrós, Lluís Capdevila, Joan Sánchez-de-Toledo, Soledad Gallego, Tomás Blasco Blasco,
Abstract This research assesses Health-Related Quality of Life (HRQoL) in a Spanish sample of adolescent cancer survivors, and analyzes the relationship between HRQoL, coping styles and physical exercise. Forty-two survivors (12–19 years), who were ≥ 1 year of remission, completed standardized measures of HRQoL (CHIP-AE), coping strategies (ACS) and physical exercise (AECEF). Mean scores in all HRQoL domains were within normative values. Multiple regression analysis revealed that physical exercise and ...
Tópico(s): Adolescent and Pediatric Healthcare
2013 - Cambridge University Press | The Spanish Journal of Psychology
Diego Castillo, Rafael Guayta, Jordi Giner, Felip Burgos, Cristina Capdevila, Joan B. Soriano, Mercè Barau, Pere Casán,
BackgroundCOPD case finding is currently recommended at primary and tertiary care levels only.AimTo evaluate the feasibility of a community pharmacy program for COPD case finding in high-risk customers by means of spirometry.MethodsPilot cross-sectional descriptive study in 13 urban community pharmacies in Barcelona, Spain, from April to May 2007. Customers >40 years old with respiratory symptoms and/or a history of smoking were invited to participate in the study during pharmacists' routine work ...
Tópico(s): Respiratory and Cough-Related Research
2009 - Elsevier BV | Respiratory Medicine
Liane S. Canas, Erika Molteni, Jie Deng, Carole H. Sudre, Benjamin Murray, Eric Kerfoot, Michela Antonelli, Khaled Rjoob, Joan Capdevila Pujol, Lorenzo Polidori, Anna May, Marc F. Österdahl, Ronan Whiston, Nathan J. Cheetham, Vicky Bowyer, Tim D. Spector, Alexander Hammers, Emma L. Duncan, Sébastien Ourselin, Claire J. Steves, Marc Modat,
Summary Background Self-reported symptom studies rapidly increased understanding of SARS-CoV-2 during the COVID-19 pandemic and enabled monitoring of long-term effects of COVID-19 outside hospital settings. Post-COVID-19 condition presents as heterogeneous profiles, which need characterisation to enable personalised patient care. We aimed to describe post-COVID-19 condition profiles by viral variant and vaccination status. Methods In this prospective longitudinal cohort study, we analysed data from UK- ...
Tópico(s): COVID-19 Clinical Research Studies
2023 - Elsevier BV | The Lancet Digital Health
Beatrice Kennedy, Hugo Fitipaldi, Ulf Hammar, Marlena Maziarz, Neli Tsereteli, Nikolay Oskolkov, Georgios Varotsis, Camilla A. Franks, Diem Nguyen, Lampros Spiliopoulos, Hans‐Olov Adami, Jonas Björk, Stefan Engblom, Katja Fall, Anna Grimby‐Ekman, Jan‐Eric Litton, Mats Martinell, Anna Oudin, Torbjörn Sjöström, Toomas Timpka, Carole H. Sudre, Mark S. Graham, Julien Lavigne du Cadet, Andrew T. Chan, Richard Davies, Sajaysurya Ganesh, Anna May, Sébastien Ourselin, Joan Capdevila Pujol, Somesh Selvachandran, Jonathan Wolf, Tim D. Spector, Claire J. Steves, Maria F. Gomez, Paul W. Franks, Tove Fall,
Abstract The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of symptomatic COVID-19, with an AUC of 0.78 (95% CI 0.74–0.83) in an external dataset. These individual ...
Tópico(s): COVID-19 diagnosis using AI
2022 - Nature Portfolio | Nature Communications
Jordi Merino, Inbar Linenberg, Kate Bermingham, Sajaysurya Ganesh, Elco Bakker, Linda M. Delahanty, Andrew T. Chan, Joan Capdevila Pujol, Jonathan Wolf, Haya Al Khatib, Paul W. Franks, Tim D. Spector, José M. Ordovás, Sarah Berry, Ana M. Valdes,
Continuous glucose monitor (CGM) devices enable characterization of individuals' glycemic variation. However, there are concerns about their reliability for categorizing glycemic responses to foods that would limit their potential application in personalized nutrition recommendations.We aimed to evaluate the concordance of 2 simultaneously worn CGM devices in measuring postprandial glycemic responses.Within ZOE PREDICT (Personalised Responses to Dietary Composition Trial) 1, 394 participants wore ...
Tópico(s): Diabetes Management and Research
2022 - Elsevier BV | American Journal of Clinical Nutrition
Erika Molteni, Liane S. Canas, Kerstin Kläser, Jie Deng, Sunil Bhopal, Robert C. Hughes, Liyuan Chen, Benjamin Murray, Eric Kerfoot, Michela Antonelli, Carole H. Sudre, Joan Capdevila Pujol, Lorenzo Polidori, Anna May, Prof Alexander Hammers, Jonathan Wolf, Prof Tim D. Spector, Claire J. Steves, Prof Sebastien Ourselin, Michael Absoud, Marc Modat, Emma L. Duncan,
We aimed to explore the effectiveness of one-dose BNT162b2 vaccination upon SARS-CoV-2 infection, its effect on COVID-19 presentation, and post-vaccination symptoms in children and adolescents (CA) in the UK during periods of Delta and Omicron variant predominance.In this prospective longitudinal cohort study, we analysed data from 115,775 CA aged 12-17 years, proxy-reported through the Covid Symptom Study (CSS) smartphone application. We calculated post-vaccination infection risk after one dose of ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2022 - Elsevier BV | The Lancet Regional Health - Europe
Cristina Menni, Ana M. Valdes, Lorenzo Polidori, Michela Antonelli, Satya Penamakuri, Ana Nogal, Panayiotis Louca, Anna May, Jane C. Figueiredo, Christina Hu, Erika Molteni, Liane S. Canas, Marc F. Österdahl, Marc Modat, Carole H. Sudre, Ben Fox, Alexander Hammers, Jonathan Wolf, Joan Capdevila Pujol, Andrew T. Chan, Sean P. David, Claire J. Steves, Sébastien Ourselin, Tim D. Spector,
The SARS-CoV-2 variant of concern, omicron, appears to be less severe than delta. We aim to quantify the differences in symptom prevalence, risk of hospital admission, and symptom duration among the vaccinated population.
Tópico(s): Long-Term Effects of COVID-19
2022 - Elsevier BV | The Lancet
Cristina Menni, Anna May, Lorenzo Polidori, Panayiotis Louca, Jonathan Wolf, Joan Capdevila Pujol, Christina Hu, Sébastien Ourselin, Claire J. Steves, Ana M. Valdes, Tim D. Spector,
BackgroundWith the surge of new SARS-CoV-2 variants, countries have begun offering COVID-19 vaccine booster doses to high-risk groups and, more recently, to the adult population in general. However, uncertainty remains over how long primary vaccination series remain effective, the ideal timing for booster doses, and the safety of heterologous booster regimens. We aimed to investigate COVID-19 primary vaccine series effectiveness and its waning, and the safety and effectiveness of booster doses, ...
Tópico(s): Vaccine Coverage and Hesitancy
2022 - Elsevier BV | The Lancet Infectious Diseases
Kerstin Kläser, Erika Molteni, Mark S. Graham, Liane S. Canas, Marc F. Österdahl, Michela Antonelli, Liyuan Chen, Jie Deng, Benjamin Murray, Eric Kerfoot, Jonathan Wolf, Anna May, Ben Fox, Joan Capdevila Pujol, David M. Aanensen, Khalil Abudahab, Helen Adams, Alexander Adams, Safiah Afifi, Dinesh Aggarwal, Shazaad S. Y. Ahmad, Louise Aigrain, Adela Alcolea-Medina, Nabil-Fareed Alikhan, Elias Allara, Roberto Amato, Adrienn Angyal, Tara Annett, Stephen Aplin, Cristina V. Ariani, Hibo Asad, Amy Ash, Paula Ashfield, Fiona Ashford, Laura Atkinson, Stephen W. Attwood, Cressida Auckland, Alp Aydin, David Baker, Paul Baker, Carlos E. Balcazar, Jonathan K. Ball, Jeffrey C. Barrett, Magdalena Barrow, Edward Barton, Matthew Bashton, Andrew R. Bassett, Rahul Batra, Chris Baxter, Nadua Bayzid, Charlotte Beaver, Angela H. Beckett, Shaun M. Beckwith, Luke Bedford, Robert Beer, Andrew D. Beggs, Katherine L. Bellis, Louise Berry, Beatrice Bertolusso, Angus Best, Emma Betteridge, David Bibby, Kelly Bicknell, Debbie Binns, Alec Birchley, Paul Bird, Chloe Bishop, Rachel Blacow, Victoria Blakey, Beth Blane, Frances Bolt, James Bonfield, Stephen Bonner, David Bonsall, Tim Boswell, Andrew Bosworth, Yann Bourgeois, Olivia Boyd, Declan Bradley, Cassie Breen, Catherine Bresner, Judith Breuer, Stephen Bridgett, Iraad F. Bronner, Ellena Brooks, Alice Broos, Julianne R. Brown, Giselda Bucca, Sarah L. Buchan, David Buck, Matthew Bull, Phillipa Burns, Shirelle Burton-Fanning, Timothy Byaruhanga, Matthew Byott, Sharon L. Campbell, Alessandro M. Carabelli, James S. Cargill, Matthew Carlile, Silvia Carvalho, Anna Casey, Anibolina Castigador, Jana Catalan, Vicki Chalker, Nicola J. Chaloner, Meera Chand, Joseph Chappell, Themoula Charalampous, Wendy Chatterton, Yasmin Chaudhry, Carol Churcher, Gemma Clark, Phillip Clarke, Benjamin J. Cogger, Kevin D. Cole, Jennifer Collins, Rachel Colquhoun, Thomas R. Connor, Kate F. Cook, Jason D. Coombes, Sally Corden, Claire Cormie, Nicholas Cortes, Marius Cotic, Seb Cotton, Simon Cottrell, Lindsay Coupland, MacGregor Cox, Alison Cox, Noel Craine, Liam Crawford, Aidan Cross, Matthew Crown, Dorian Crudgington, Nicola Cumley, Tanya Curran, Martin D. Curran, Ana da Silva Filipe, Gavin Dabrera, Alistair C. Darby, Rose K. Davidson, Alisha Davies, Robert M. Davies, Thomas P. Davis, Daniela De Angelis, Elen De Lacy, Leonardo de Oliveira Martins, Thushan I. de Silva, Johnny Debebe, Rebecca Denton-Smith, Samir Dervisevic, Rebecca Dewar, Jayasree Dey, Joana Dias, Donald Dobie, Matthew J. Dorman, Fatima Downing, Megan Driscoll, Louis du Plessis, Nichola Duckworth, Jillian Durham, Kirstine Eastick, Lisa J. Easton, Richard Eccles, Jonathan D. Edgeworth, Sue Edwards, Kate El Bouzidi, Sahar Eldirdiri, Nicholas Ellaby, Scott Elliott, Gary Eltringham, Leah Ensell, Michelle J. Erkiert, Marina Escalera Zamudio, Sarah Essex, Johnathan M. Evans, Cariad Evans, William V. Everson, Derek Fairley, Karlie Fallon, Arezou Fanaie, Ben W. Farr, Christopher Fearn, Theresa Feltwell, Lynne Ferguson, Laia Fina, Flavia Flaviani, Vicki M. Fleming, Stephen R. Forrest, Ebenezer Foster-Nyarko, Benjamin H. Foulkes, Luke Foulser, Mireille Fragakis, Dan Frampton, Sarah François, Christophe Fraser, Timothy M. Freeman, Helen Fryer, Marc Fuchs, William Fuller, Kavitha Gajee, Katerina Galai, Abbie Gallagher, Eileen Gallagher, Michael D. Gallagher, Marta Gallis, Amy Gaskin, Bree Gatica-Wilcox, Lily Geidelberg, Matthew Gemmell, Iliana Georgana, Ryan P. George, Laura Gifford, Lauren Gilbert, Sophia T. Girgis, Sharon Glaysher, Emily J. Goldstein, Tanya Golubchik, Andrea N. Gomes, Sónia Gonçalves, Ian Goodfellow, Scott Goodwin, Salman Goudarzi, Marina Gourtovaia, Clive Graham, Lee Graham, Paul R. Grant, Luke R. Green, Angie Green, Jane Greenaway, Richard I. Gregory, Martyn F. Guest, Rory Gunson, Ravindra K. Gupta, Bernardo Gutiérrez, Sam Haldenby, William L. Hamilton, Samantha E. Hansford, Tanzina Haque, Kathryn Harris, Ian Harrison, Ewan M. Harrison, Jennifer Hart, John A. Hartley, William T. Harvey, M J Harvey, Mohammed O. Hassan-Ibrahim, Judith Heaney, Thomas Helmer, John Henderson, Andrew R. Hesketh, Jessica Hey, David Heyburn, Ellen E. Higginson, Verity Hill, Jack Hill, Rachel A. Hilson, Ember Hilvers, Matthew T. G. Holden, Amy Hollis, Christopher W. Holmes, Nadine Holmes, Alison Holmes, Richard Hopes, Hailey Hornsby, Myra Hosmillo, Catherine Houlihan, Hannah C. Howson‐Wells, Sharon N. Hsu, Jonathan Hubb, Hannah Huckson, Warwick Hughes, Joseph Hughes, Margaret Hughes, Stephanie Hutchings, Giles Idle, Chris J. Illingworth, Robert Impey, Dianne Irish-Tavares, Miren Iturriza-Gomara, Rhys Izuagbe, Christopher Jackson, Ben Jackson, Leigh Jackson, Kathryn Jackson, David K. Jackson, Aminu S. Jahun, Victoria James, Keith James, Christopher Jeanes, Aaron R. Jeffries, Sarah Jeremiah, Andrew Jermy, John P.T. Mo, Rob Johnson, KATE JOHNSON,
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive for SARS-CoV-2 from May 26 to July 1, 2021 (Delta overwhelmingly the predominant circulating UK variant), compared (1:1, age- and sex-matched) with individuals presenting from December ...
Nature Portfolio
Erika Molteni, Carole H. Sudre, Liane S. Canas, Sunil Bhopal, Robert C. Hughes, Liyuan Chen, Jie Deng, Benjamin Murray, Eric Kerfoot, Michela Antonelli, Mark S. Graham, Kerstin Kläser, Anna May, Christina Hu, Joan Capdevila Pujol, Jonathan Wolf, Alexander Hammers, Timothy D. Spector, Sébastien Ourselin, Marc Modat, Claire J. Steves, Michael Absoud, Emma L. Duncan,
Background: The Delta (B.1.617.2) SARS-CoV-2 variant was the predominant UK circulating strain between May and November 2021. We investigated whether COVID-19 from Delta infection differed from infection with previous variants in children. Methods: Through the prospective COVID Symptom Study, 109,626 UK school-aged children were proxy-reported between 28 December 2020 and 8 July 2021. We selected all symptomatic children who tested positive for SARS-CoV-2 and were proxy-reported at least weekly, ...
Tópico(s): Long-Term Effects of COVID-19
2022 - Multidisciplinary Digital Publishing Institute | Children
Michela Antonelli, Joan Capdevila Pujol, Tim D. Spector, Sébastien Ourselin, Claire J. Steves,
The omicron variant of SARS-CoV-2 (PANGO B.1.1.529) spread rapidly across the world, out-competing former variants soon after it was first detected in November, 2021. According to the Our World in Data COVID-19 database, In Europe, the number of confirmed cases reported between December, 2021, and March, 2022 (omicron period) has exceeded all previously reported cases. Omicron appears to cause less severe acute illness than previous variants, at least in vaccinated populations. However, the potential ...
Tópico(s): COVID-19 and Mental Health
2022 - Elsevier BV | The Lancet
Francesco Asnicar, Sarah Berry, Ana M. Valdes, Long H. Nguyen, Gianmarco Piccinno, David A. Drew, Emily R. Leeming, Rachel Gibson, Caroline Le Roy, Haya Al Khatib, Lucy Francis, Mohsen Mazidi, Olatz Mompeó, Mireia Valles‐Colomer, Adrian Tett, Francesco Beghini, Léonard Dubois, Davide Bazzani, Andrew Maltez Thomas, Chloe Mirzayi, Asya Khleborodova, Sehyun Oh, Rachel Hine, Christopher Bonnett, Joan Capdevila Pujol, Serge Danzanvilliers, Francesca Giordano, Ludwig Geistlinger, Levi Waldron, Richard Davies, George Hadjigeorgiou, Jonathan Wolf, José M. Ordovás, Christopher D. Gardner, Paul W. Franks, Andrew T. Chan, Curtis Huttenhower, Tim D. Spector, Nicola Segata,
The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2021 - Nature Portfolio | Nature Medicine
Liane S. Canas, Carole H. Sudre, Joan Capdevila Pujol, Lorenzo Polidori, Benjamin Murray, Erika Molteni, Mark S. Graham, Kerstin Kläser, Michela Antonelli, Sarah Berry, Richard Davies, Long H. Nguyen, David A. Drew, Jonathan Wolf, Andrew T. Chan, Tim D. Spector, Claire J. Steves, Sébastien Ourselin, Marc Modat,
SummaryBackgroundSelf-reported symptoms during the COVID-19 pandemic have been used to train artificial intelligence models to identify possible infection foci. To date, these models have only considered the culmination or peak of symptoms, which is not suitable for the early detection of infection. We aimed to estimate the probability of an individual being infected with SARS-CoV-2 on the basis of early self-reported symptoms to enable timely self-isolation and urgent testing.MethodsIn this large- ...
Tópico(s): COVID-19 epidemiological studies
2021 - Elsevier BV | The Lancet Digital Health
Carole H. Sudre, Benjamin Murray, Thomas Varsavsky, Mark S. Graham, Rose Penfold, Ruth C. E. Bowyer, Joan Capdevila Pujol, Kerstin Kläser, Michela Antonelli, Liane S. Canas, Erika Molteni, Marc Modat, M. Jorge Cardoso, Anna May, Sajaysurya Ganesh, Richard Davies, Long H. Nguyen, David A. Drew, Christina M. Astley, Amit D. Joshi, Jordi Merino, Neli Tsereteli, Tove Fall, Maria F. Gomez, Emma L. Duncan, Cristina Menni, Frances M. K. Williams, Paul W. Franks, Andrew T. Chan, Jonathan Wolf, Sébastien Ourselin, Tim D. Spector, Claire J. Steves,
In the version of this article initially published, linkage of the following authors to affiliation 3 (Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK) was incorrect: Benjamin Murray, Thomas Varsavsky, Mark S. Graham, Kerstin Klaser, Michela Antonelli, Liane S. Canas, Erika Molteni, Marc Modat, M. Jorge Cardoso and Sebastien Ourselin. The correct linkage is to affiliation 1 (School of Biomedical Engineering & Imaging Sciences, King’s College ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Nature Portfolio | Nature Medicine
Chun‐Han Lo, Long H. Nguyen, David A. Drew, Erica T. Warner, Amit D. Joshi, Mark S. Graham, Adjoa Anyane‐Yeboa, Fatma M. Shebl, Christina M. Astley, Jane C. Figueiredo, Chuan‐Guo Guo, Wenjie Ma, Raaj S. Mehta, Sohee Kwon, Mingyang Song, Richard Davies, Joan Capdevila Pujol, Carole H. Sudre, Jonathan Wolf, Yvette C. Cozier, Lynn Rosenberg, Lynne R. Wilkens, Christopher A. Haiman, Loı̈c Le Marchand, Julie R. Palmer, Tim D. Spector, Sébastien Ourselin, Claire J. Steves, Andrew T. Chan,
There is limited prior investigation of the combined influence of personal and community-level socioeconomic factors on racial/ethnic disparities in individual risk of coronavirus disease 2019 (COVID-19).We performed a cross-sectional analysis nested within a prospective cohort of 2,102,364 participants from March 29, 2020 in the United States (US) and March 24, 2020 in the United Kingdom (UK) through December 02, 2020 via the COVID Symptom Study smartphone application. We examined the contribution ...
Tópico(s): COVID-19 epidemiological studies
2021 - Elsevier BV | EClinicalMedicine
Carole H. Sudre, Ayya Keshet, Mark S. Graham, Amit D. Joshi, Smadar Shilo, Hagai Rossman, Benjamin Murray, Erika Molteni, Kerstin Kläser, Liane S. Canas, Michela Antonelli, Long H. Nguyen, David A. Drew, Marc Modat, Joan Capdevila Pujol, Sajaysurya Ganesh, Jonathan Wolf, Tomer Meir, Andrew T. Chan, Claire J. Steves, Tim D. Spector, John S. Brownstein, Eran Segal, Sébastien Ourselin, Christina M. Astley,
SummaryBackgroundMultiple voluntary surveillance platforms were developed across the world in response to the COVID-19 pandemic, providing a real-time understanding of population-based COVID-19 epidemiology. During this time, testing criteria broadened and health-care policies matured. We aimed to test whether there were consistent associations of symptoms with SARS-CoV-2 test status across three surveillance platforms in three countries (two platforms per country), during periods of testing and ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Elsevier BV | The Lancet Digital Health
Erika Molteni, Carole H. Sudre, Liane S. Canas, Sunil Bhopal, Robert C. Hughes, Michela Antonelli, Benjamin Murray, Kerstin Kläser, Eric Kerfoot, Liyuan Chen, Jie Deng, Christina Hu, Somesh Selvachandran, K. L. Q. Read, Joan Capdevila Pujol, Alexander Hammers, Tim D. Spector, Sébastien Ourselin, Claire J. Steves, Marc Modat, Michael Absoud, Emma L. Duncan,
In children, SARS-CoV-2 infection is usually asymptomatic or causes a mild illness of short duration. Persistent illness has been reported; however, its prevalence and characteristics are unclear. We aimed to determine illness duration and characteristics in symptomatic UK school-aged children tested for SARS-CoV-2 using data from the COVID Symptom Study, one of the largest UK citizen participatory epidemiological studies to date.
Tópico(s): COVID-19 and Mental Health
2021 - Elsevier BV | The Lancet Child & Adolescent Health
Michela Antonelli, Joan Capdevila Pujol, Arpit Chaudhari, Julia Granerød, Liane S. Canas, Mark S. Graham, Kerstin Kläser, Marc Modat, Erika Molteni, Benjamin Murray, Carole H. Sudre, Richard Davies, Anna May, Long H. Nguyen, David A. Drew, Amit D. Joshi, Andrew T. Chan, Jakob P. Cramer, Tim D. Spector, Jonathan Wolf, Sébastien Ourselin, Claire J. Steves, A Loeliger,
Diagnostic work-up following any COVID-19 associated symptom will lead to extensive testing, potentially overwhelming laboratory capacity whilst primarily yielding negative results. We aimed to identify optimal symptom combinations to capture most cases using fewer tests with implications for COVID-19 vaccine developers across different resource settings and public health.UK and US users of the COVID-19 Symptom Study app who reported new-onset symptoms and an RT-PCR test within seven days of symptom ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2021 - Elsevier BV | Journal of Infection
Mohsen Mazidi, Ana M. Valdes, José M. Ordovás, Wendy L. Hall, Joan Capdevila Pujol, Jonathan Wolf, George Hadjigeorgiou, Nicola Segata, Naveed Sattar, Robert W. Koivula, Tim D. Spector, Paul W. Franks, Sarah Berry,
Meal-induced metabolic changes trigger an acute inflammatory response, contributing to chronic inflammation and associated diseases. We aimed to characterize variability in postprandial inflammatory responses using traditional (IL-6) and novel [glycoprotein acetylation (GlycA)] biomarkers of inflammation and dissect their biological determinants with a focus on postprandial glycemia and lipemia. Postprandial (0–6 h) glucose, triglyceride (TG), IL-6, and GlycA responses were measured at multiple intervals ...
Tópico(s): Dietary Effects on Health
2021 - Elsevier BV | American Journal of Clinical Nutrition
Jordi Merino, Amit D. Joshi, Long H. Nguyen, Emily R. Leeming, Mohsen Mazidi, David A. Drew, Rachel Gibson, Mark S. Graham, Chun‐Han Lo, Joan Capdevila Pujol, Benjamin Murray, Christina Hu, Somesh Selvachandran, Alexander Hammers, Shilpa N. Bhupathiraju, Shreela V. Sharma, Carole H. Sudre, Christina M. Astley, Jorge E. Chavarro, Sohee Kwon, Wenjie Ma, Cristina Menni, Walter C. Willett, Sébastien Ourselin, Claire J. Steves, Jonathan Wolf, Paul W. Franks, Timothy D. Spector, Sarah Berry, Andrew T. Chan,
Poor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation.
Tópico(s): Diet and metabolism studies
2021 - BMJ | Gut
Carole H. Sudre, Karla A. Lee, Mary Ní Lochlainn, Thomas Varsavsky, Benjamin Murray, Mark S. Graham, Cristina Menni, Marc Modat, Ruth C. E. Bowyer, Long H. Nguyen, David A. Drew, Amit D. Joshi, Wenjie Ma, Chuan‐Guo Guo, Chun‐Han Lo, Sajaysurya Ganesh, Abubakar Buwe, Joan Capdevila Pujol, Julien Lavigne du Cadet, Alessia Visconti, Maxim B. Freidin, Julia S. El-Sayed Moustafa, Mario Falchi, Richard Davies, Maria F. Gomez, Tove Fall, M. Jorge Cardoso, Jonathan Wolf, Paul W. Franks, Andrew T. Chan, Tim D. Spector, Claire J. Steves, Sébastien Ourselin,
As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus disease 2019 (COVID-19), we asked whether documenting symptom time series over the first few days informs outcome. Unsupervised time series clustering over symptom presentation was performed on data collected from a training dataset of completed cases enlisted early from the COVID Symptom Study Smartphone application, yielding six distinct symptom presentations. Clustering was validated on an independent ...
Tópico(s): COVID-19 and Mental Health
2021 - American Association for the Advancement of Science | Science Advances
Cristina Menni, Kerstin Kläser, Anna May, Lorenzo Polidori, Joan Capdevila Pujol, Panayiotis Louca, Carole H. Sudre, Long H. Nguyen, David A. Drew, Jordi Merino, Christina Hu, Somesh Selvachandran, Michela Antonelli, Benjamin Murray, Liane S. Canas, Erika Molteni, Mark S. Graham, Marc Modat, Amit D. Joshi, Massimo Mangino, Alexander Hammers, Anna L. Goodman, Andrew T. Chan, Jonathan Wolf, Claire J. Steves, Ana M. Valdes, Sébastien Ourselin, Tim D. Spector,
The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We aimed to investigate the safety and effectiveness of these vaccines in a UK community setting.
Tópico(s): Vaccine Coverage and Hesitancy
2021 - Elsevier BV | The Lancet Infectious Diseases
Michela Antonelli, Rose Penfold, Jordi Merino, Carole H. Sudre, Erika Molteni, Sarah Berry, Liane S. Canas, Mark S. Graham, Kerstin Kläser, Marc Modat, Benjamin Murray, Eric Kerfoot, Liyuan Chen, Jie Deng, Marc F. Österdahl, Nathan J. Cheetham, David A. Drew, Long H. Nguyen, Joan Capdevila Pujol, Christina Hu, Somesh Selvachandran, Lorenzo Polidori, Anna May, Jonathan Wolf, Andrew T. Chan, Alexander Hammers, Emma L. Duncan, Tim D. Spector, Sébastien Ourselin, Claire J. Steves,
BackgroundCOVID-19 vaccines show excellent efficacy in clinical trials and effectiveness in real-world data, but some people still become infected with SARS-CoV-2 after vaccination. This study aimed to identify risk factors for post-vaccination SARS-CoV-2 infection and describe the characteristics of post-vaccination illness.MethodsThis prospective, community-based, nested, case-control study used self-reported data (eg, on demographics, geographical location, health risk factors, and COVID-19 test ...
Tópico(s): Vaccine Coverage and Hesitancy
2021 - Elsevier BV | The Lancet Infectious Diseases
Carole H. Sudre, Benjamin Murray, Thomas Varsavsky, Mark S. Graham, Rose Penfold, Ruth C. E. Bowyer, Joan Capdevila Pujol, Kerstin Kläser, Michela Antonelli, Liane S. Canas, Erika Molteni, Marc Modat, M. Jorge Cardoso, Anna May, Sajaysurya Ganesh, Richard Davies, Long H. Nguyen, David A. Drew, Christina M. Astley, Amit D. Joshi, Jordi Merino, Neli Tsereteli, Tove Fall, Maria F. Gomez, Emma L. Duncan, Cristina Menni, Frances M. K. Williams, Paul W. Franks, Andrew T. Chan, Jonathan Wolf, Sébastien Ourselin, Tim D. Spector, Claire J. Steves,
Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called ‘long COVID’, are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app1. A total of 558 (13.3%) participants reported symptoms lasting ≥28 days, 189 (4.5%) for ≥8 weeks and 95 (2.3%) for ≥12 ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Nature Portfolio | Nature Medicine
Mark S. Graham, Carole H. Sudre, Anna May, Michela Antonelli, Benjamin Murray, Thomas Varsavsky, Kerstin Kläser, Liane S. Canas, Erika Molteni, Marc Modat, David Drew, Long H. Nguyen, Lorenzo Polidori, Somesh Selvachandran, Christina Hu, Joan Capdevila Pujol, Alexander Hammers, Andrew T. Chan, Jonathan Wolf, Tim D. Spector, Claire J. Steves, Sébastien Ourselin, Cherian Koshy, Amy Ash, Emma L. Wise, Nathan Moore, Matilde Mori, Nick Cortes, Jessica Lynch, Stephen P. Kidd, Derek Fairley, Tanya Curran, James McKenna, Helen Adams, Christophe Fraser, Tanya Golubchik, David Bonsall, Mohammed O. Hassan-Ibrahim, Cassandra S. Malone, Benjamin J. Cogger, Michelle Wantoch, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, John P.T. Mo, Robert Beer, Safiah Afifi, Siân Morgan, Angela Marchbank, Anna Price, Christine Kitchen, Huw Gulliver, Ian Merrick, Joel Southgate, Martyn F. Guest, Robert J. Munn, Trudy Workman, Thomas R. Connor, William Fuller, Catherine Bresner, Luke B. Snell, Amita Patel, Themoula Charalampous, Gaia Nebbia, Rahul Batra, Jonathan Edgeworth, Samuel C. Robson, Angela H. Beckett, David M. Aanensen, Anthony P. Underwood, Corin Yeats, Khalil Abudahab, Ben Taylor, Mirko Menegazzo, Gemma Clark, Darren Smith, Manjinder Khakh, Vicki M. Fleming, Michelle M. Lister, Hannah C. Howson‐Wells, Louise Berry, Tim Boswell, Amelia Joseph, Iona Willingham, Carl Jones, Christopher W. Holmes, Paul Bird, Thomas Helmer, Karlie Fallon, Julian W. Tang, Veena Raviprakash, Sharon L. Campbell, Nicola Sheriff, Victoria Blakey, Lesley-Anne Williams, Matthew Loose, Nadine Holmes, Christopher Moore, Matthew Carlile, Victoria Wright, Fei Sang, Johnny Debebe, Francesc Coll, Adrian W. Signell, Gilberto Betancor, Harry Wilson, Sahar Eldirdiri, Anita Kenyon, Thomas P. Davis, Oliver G. Pybus, Louis du Plessis, Alex E. Zarebski, Jayna Raghwani, Moritz U. G. Kraemer, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Marina Escalera Zamudio, Bernardo Gutiérrez, M. Estée Török, William L. Hamilton, Ian Goodfellow, Grant Hall, Aminu S. Jahun, Yasmin Chaudhry, Myra Hosmillo, Malte L. Pinckert, Iliana Georgana, Samuel Moses, Hannah Lowe, Luke Bedford, Jonathan D. Moore, Susanne Stonehouse, Chloe L. Fisher, Ali Raza Awan, John Boyes, Judith Breuer, Kathryn Harris, Julianne R. Brown, Divya Shah, Laura Atkinson, Jack C. D. Lee, Nathaniel Storey, Flavia Flaviani, Adela Alcolea-Medina, Rebecca Williams, Gabrielle Vernet, Michael Chapman, Lisa J. Levett, Judith Heaney, Wendy Chatterton, Monika Pusok, Li Xu-McCrae, Darren Smith, Matthew Bashton, Gregory R. Young, Alison Holmes, Paul Randell, Alison Cox, Pinglawathee Madona, Frances Bolt, James Price, Siddharth Mookerjee, Manon Ragonnet‐Cronin, Fabrícia F. Nascimento, David Jorgensen, Igor Siveroni, Rob Johnson, Olivia Boyd, Lily Geidelberg, Erik Volz, Aileen Rowan, Graham P. Taylor, Katherine Smollett, Nicholas J. Loman, Joshua Quick, Claire McMurray, Joanne Stockton, Samuel M. Nicholls, Will Rowe, Radoslaw Poplawski, Alan McNally, Rocio T. Martinez Nunez, Jenifer Mason, Trevor I. Robinson, Elaine O’Toole, Joanne Watts, Cassie Breen, Angela Cowell, Graciela Sluga, Nicholas W. Machin, Shazaad Ahmad, Ryan P. George, Fenella Halstead, Venkat Sivaprakasam, Wendy Hogsden, Chris J. Illingworth, Christopher Jackson, Emma C. Thomson, James G. Shepherd, Patawee Asamaphan, Marc Niebel, Kathy Li, Rajiv Shah, Natasha Jesudason, L. Tong, Alice Broos, Daniel Mair, Jenna Nichols, Stephen Carmichael, Kyriaki Nomikou, Elihú Aranday-Cortés, Natasha M. Johnson, Igor Starinskij, Ana da Silva Filipe, David L. Robertson, Richard Orton, Joseph Hughes, Vattipally B. Sreenu, Joshua B. Singer, Seema Nickbakhsh, Antony Hale, Louissa Macfarlane-Smith, Katherine L. Harper, Holli Carden, Yusri Taha, Brendan Payne, Shirelle Burton-Fanning, Sheila Waugh, Jennifer Collins, Gary Eltringham, Steven Rushton, Sarah H. O’Brien, Allan Bradley, Alasdair Maclean, Guy Mollett, Rachel Blacow, Kate Templeton, M. McHugh, Rebecca Dewar, Elizabeth Wastenge, Samir Dervisevic, Rachael Stanley, Emma Meader, Lindsay Coupland, Louise Smith, Clive Graham, Edward Barton, Debra Padgett, Garren Scott, Emma Swindells, Jane Greenaway, Andrew Nelson, Clare M. McCann, Wen C. Yew, Monique Andersson, Tim Peto, Anita Justice, David W. Eyre, Derrick W. Crook, Tim J. Sloan, Nichola Duckworth, Sarah Walsh, Anoop Chauhan, Sharon Glaysher, Kelly Bicknell, Sarah Wyllie, Scott Elliott, Allyson Lloyd, Robert Impey, Nick Levene, Lynn Monaghan, Declan Bradley, Tim Wyatt, Elias Allara, Clare Pearson, Husam Osman, Andrew Bosworth, Esther Robinson, Peter Muir, Ian B. Vipond, Richard Hopes, Hannah M. Pymont, Stephanie Hutchings, Martin D. Curran, Surendra Parmar, Angie Lackenby, Tamyo Mbisa, Steven G. Platt, Shahjahan Miah, David Bibby, Carmen de Guerrero Manso, Jonathan Hubb, Meera Chand,
BackgroundThe SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease course, reinfection rates, or transmissibility.MethodsWe did an ecological study to examine the association between the regional proportion of infections with the SARS-CoV-2 B.1.1.7 variant and reported symptoms, disease course, rates of reinfection, and transmissibility. ...
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