Joana Lemos, Khemraj Hirani, Matthias von Herrath,
Type 1 diabetes (T1D) is caused by an autoimmune process which culminates in the destruction of insulin-producing beta cells in the pancreas. It is widely believed that a complex and multifactorial interplay between genetic and environmental factors, such as viruses, play a crucial role in the development of the disease. Research over the past few decades has shown that there is not one single viral culprit, nor one single genetic pathway, causing the disease. Rather, viral infections, most notably ...
Tópico(s): Diabetes Management and Research
2024 - Frontiers Media | Frontiers in Immunology
Sara Gomes, Liliana Raimundo, Joana Soares, Joana B. Loureiro, Miguel Leão, Helena Ramos, Madalena Monteiro, Agostinho Lemos, Joana Moreira, Madalena Pinto, Petr Chlapek, Renata Veselská, Emı́lia Sousa, Lucı́lia Saraiva,
TAp73 is a key tumor suppressor protein, regulating the transcription of unique and shared p53 target genes with crucial roles in tumorigenesis and therapeutic response. As such, in tumors with impaired p53 signaling, like neuroblastoma, TAp73 activation represents an encouraging strategy, alternative to p53 activation, to suppress tumor growth and chemoresistance. In this work, we report a new TAp73-activating agent, the 1-carbaldehyde-3,4-dimethoxyxanthone (LEM2), with potent antitumor activity. ...
Tópico(s): Cell death mechanisms and regulation
2019 - Elsevier BV | Cancer Letters
Luísa T. Ferreira, Bernardo Orr, Girish Rajendraprasad, António J. Pereira, Carolina Lemos, Joana T. Lima, Clàudia Guasch Boldú, Jorge G. Ferreira, Marin Barišić, Hélder Maiato,
Incorrect kinetochore–microtubule attachments during mitosis can lead to chromosomal instability, a hallmark of human cancers. Mitotic error correction relies on the kinesin-13 MCAK, a microtubule depolymerase whose activity in vitro is suppressed by α-tubulin detyrosination—a posttranslational modification enriched on long-lived microtubules. However, whether and how MCAK activity required for mitotic error correction is regulated by α-tubulin detyrosination remains unknown. Here we found that ...
Tópico(s): Genomics and Chromatin Dynamics
2020 - Rockefeller University Press | The Journal of Cell Biology
Produção Nacional
Revisado por pares
Eliana Marisa Ramos, Miryam Carecchio, Roberta R. Lemos, Joana Ferreira, Andrea Legati, Renee Sears, Sandy Hsu, Celeste Panteghini, Luca Magistrelli, Ettore Salsano, Silvia Esposito, Franco Taroni, Anne‐Claire Richard, Christine Tranchant, Mathieu Anheim, Xavier Ayrignac, Cyril Goizet, Marie Vidailhet, David Maltête, David Wallon, Thierry Frébourg, Lylyan Fragoso Pimentel, Daniel H. Geschwind, Olivier Vanakker, Douglas Galasko, Brent L. Fogel, A. Micheil Innes, Alison Ross, William B. Dobyns, Diana Alcantara, Mark O’Driscoll, Didier Hannequin, Dominique Campion, João Ricardo Mendes de Oliveira, Barbara Garavaglia, Giovanni Coppola, Gaël Nicolas,
Primary familial brain calcification (PFBC) is a rare cerebral microvascular calcifying disorder with a wide spectrum of motor, cognitive, and neuropsychiatric symptoms. It is typically inherited as an autosomal-dominant trait with four causative genes identified so far: SLC20A2, PDGFRB, PDGFB, and XPR1. Our study aimed at screening the coding regions of these genes in a series of 177 unrelated probands that fulfilled the diagnostic criteria for primary brain calcification regardless of their family ...
Tópico(s): Parathyroid Disorders and Treatments
2018 - Springer Nature | European Journal of Human Genetics
Gaël Nicolas, Mónica Sánchez-Contreras, Eliana Marisa Ramos, Roberta R. Lemos, Joana Ferreira, Denis A. P. Moura, María Jesús Sobrido, Anne‐Claire Richard, Alma Rosa Lopez, Andrea Legati, Jean‐François Deleuze, Anne Boland, Olivier Quenez, Pierre Krystkowiak, Pascal Favrole, Daniel H. Geschwind, Adi Aran, Reeval Segel, Ephrat Levy‐Lahad, Dennis W. Dickson, Giovanni Coppola, Rosa Rademakers, João Ricardo Mendes de Oliveira,
To assess the potential connection between PCDH12 and brain calcifications in a patient carrying a homozygous nonsense variant in PCDH12 and in adult patients with brain calcifications.We performed a CT scan in 1 child with a homozygous PCDH12 nonsense variant. We screened DNA samples from 53 patients with primary familial brain calcification (PFBC) and 26 patients with brain calcification of unknown cause (BCUC).We identified brain calcifications in subcortical and perithalamic regions in the patient ...
Tópico(s): Connective tissue disorders research
2017 - Wolters Kluwer | Neurology Genetics
Susete Pintéus, Marco F.L. Lemos, Joana Silva, Celso Alves, Agnieszka Zofia Neugebauer, Rafaela Freitas, Adriana Silva Santos Duarte, Rui Pedrosa,
Sargassum muticum is a brown seaweed with strong potential to be used as a functional food ingredient, mainly due to its antioxidant properties. It is widely used in traditional oriental medicine for the treatment of numerous diseases. Nevertheless, few studies have been conducted to add scientific evidence on its effects as well as on the mechanisms of action involved. In this work, the human cell line MCF-7 was used as an in vitro cellular model to evaluate the capability of Sargassum muticum ...
Tópico(s): Echinoderm biology and ecology
2017 - Multidisciplinary Digital Publishing Institute | Marine Drugs
Francisco Q. Gonçalves, Johny Pires, Anna Pliássova, Rui O. Beleza, Cristina Lemos, Joana M. Marques, Ricardo J. Rodrigues, Paula M. Canas, Attila Köfalvi, Rodrigo A. Cunha, Daniel Rial,
Abstract Adenosine is a neuromodulator mostly acting through A 1 (inhibitory) and A 2A (excitatory) receptors in the brain. A 2B receptors (A 2 B R ) are G s/q ‐protein‐coupled receptors with low expression in the brain. As A 2 B R function is largely unknown, we have now explored their role in the mouse hippocampus. We performed electrophysiological extracellular recordings in mouse hippocampal slices, and immunological analysis of nerve terminals and glutamate release in hippocampal slices and synaptosomes. ...
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Wiley | European Journal of Neuroscience
Produção Nacional
Revisado por pares
Roberta R. Lemos, Joana Ferreira, Matthew P. Keasey, João Ricardo Mendes de Oliveira,
Patients with primary familial brain calcifications (PFBC) present bilateral calcifications, often affecting basal ganglia, thalamus, and cerebellum, inherited in an autosomal dominant pattern of segregation. Affected individuals display a wide variety of motor and cognitive impairments such as parkinsonism, dystonia, migraine, dementia, psychosis, and mood symptoms. Worldwide growth in the availability of neuroimaging procedures, combined with careful screening of patients and their relatives, has ...
Tópico(s): Medical Imaging and Pathology Studies
2013 - Elsevier BV | International review of neurobiology
Eduardo Esteves, Ana Karina Mendes, Marlene Barros, C.C.R. Figueiredo, Joana Andrade, Joana Capelo, António Novais, Carla Rebelo, Rita Soares, Ana Lúcia de Paula Ferreira Nunes, André Ferreira, Joana Lemos, Ana Sofia Duarte, Raquel M. Silva, Liliana Bernardino, Maria José Correia, Ana Cristina Esteves, Nuno Rosa,
SARS-CoV-2 pandemic has forced frequent testing of populations. It is necessary to identify the most cost-effective strategies for the detection of COVID-19 outbreaks. Nasopharyngeal samples have been used for SARS-CoV-2 detection but require a healthcare professional to collect the sample and cause discomfort and pain to the individual. Saliva has been suggested as an appropriate fluid for the diagnosis of COVID-19. We have investigated the possibility of using pools of saliva samples to detect ...
Tópico(s): COVID-19 diagnosis using AI
2022 - Public Library of Science | PLoS ONE
Samuel Fernandes, Juliana Serrazina, I Botto, Tiago Leal, Andreia Guimarães, Joana Lemos Garcia, Isadora Rosa, Rita Prata, Diana Carvalho, João A. Cunha Neves, Pedro Henrique Campelo, Sofia Ventura, Andrea Silva, Mariana Coelho, Cristiana Sequeira, Ana Paula Oliveira, Francisco Portela, Paula Ministro, Helena Tavares de Sousa, Jaime Ramos, Isabel Claro, Raquel Gonçalves, L Correia, Rui Tato Marinho, Helena Cortez‐Pinto, Fernando Magro,
Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term.Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five-year rates of hospitalization, surgery, use of steroids, and treatment escalation were compared between ...
Tópico(s): Diagnosis and treatment of tuberculosis
2022 - Wiley | United European Gastroenterology Journal
Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, D. Abdo, Basir Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Amina Abdulle, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Sara J. Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Lisa C. Adams, Richard Adams, Tim Adams, Kirsty Adcock, Jemaimah Addai, Ade Adebiyi, Ken Adegoke, Vicki Adell, Debo Ademokun, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Dominic Affron, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Penny Agent, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Humayun Ahmad, Mohammad Ahmad, Syed A. Ahmad, Asim A. Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Iram Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, S. Hinan Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Giulia Airoldi, Myriam Aissa, Lindianne Aitken, Bini Ajay, Francis Ajeneye, Abdulakeem Ajibode, Ayesha Ajmi, Tahir Akbar, Naim Akhtar, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Olajide Akinwumiju, Olugbenro Aktinade, Ahmad Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Karina Al-Asadi, Kyriaki S. Alatzoglou, Manaf Al-Bayati, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter Alexander, Charlotte Alford, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Asad Ali, Fawzia R Ali, Hoodo Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sabira Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Allameddine Allameddine, Fiona Allan, Rachel Allan, Alison Allanson, Robert Allcock, B. Allen, Eireann Allen, Jess Allen, Kerry Allen, Laura K. Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Sara Altaf, Mary Alvarez, Balaal Alyas, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Kenneth Amenyah, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Mariam Ammoun, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Rekha Anand, Samantha Anandappa, Julie Anderson, Kevin L. Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy G. Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Susan Andrews, Gregory Andrikopoulos, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, George Apostolides, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia Aquino, Bianca Araba, Samuel Aransiola, Mariana E. G. de Araújo, Emily Arbon, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Sylvia Armstrong‐Fisher, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold,
BackgroundMany patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. ...
Elsevier BV
Joana Lemos, David A. Baidal, Camillo Ricordi, Virginia Fuenmayor, Ana Alvarez, Rodolfo Alejandro,
Type 1 diabetes (T1D) is associated with premature mortality due to acute and chronic diabetes-related complications (1). Severe hypoglycemic events (SHEs) and impaired awareness of hypoglycemia are significant contributors to the increased morbidity and mortality. Islet transplantation (ITx) has been shown to provide near-normalization of glycemic control, restoration of hypoglycemia awareness, prevention of SHEs, and improved quality of life in a select group of patients with T1D (2). To analyze overall ...
Tópico(s): Diabetes Treatment and Management
2021 - American Diabetes Association | Diabetes Care
Lídia Cunha, Ildikó Horváth, Sara Ferreira, Joana Lemos, Pedro Costa, Domingos Vieira, Dániel Sándor Veres, Krisztián Szigeti, Teresa Summavielle, Domokos Máthé, Luís F. Metello,
Translational research is changing the practice of modern medicine and the way in which health problems are approached and solved. The use of small-animal models in basic and preclinical sciences is a major keystone for these kinds of research and development strategies, representing a bridge between discoveries at the molecular level and clinical implementation in diagnostics and/or therapeutics. The development of high-resolution in vivo imaging technologies provides a unique opportunity for studying ...
Tópico(s): Advanced X-ray and CT Imaging
2013 - Adis, Springer Healthcare | Molecular Diagnosis & Therapy
Produção Nacional
Revisado por pares
Joana Lemos, Mariana Gascue Alencastro, Anita Vieceli Konrath, Marina Cargnin, Roberto Ceratti Manfro,
Malnutrition and chronic inflammation in dialysis patients negatively impact their survival prognosis, and nutrients, such as omega-3 oils, are postulated to reduce proinflammatory response. In this randomized, double-blind, multicenter, placebo-controlled trial, we investigated the effects of flaxseed oil (FO) on the inflammatory state of patients with chronic renal failure undergoing renal replacement therapy with hemodialysis (HD). We hypothesized that FO supplementation lowers C-reactive protein ( ...
Tópico(s): Advanced Glycation End Products research
2012 - Elsevier BV | Nutrition Research
Produção Nacional
Revisado por pares
Emilia Fernanda Agostinho Davanzo, Rebecca Lavarini dos Santos, Virgílio Hipólito de Lemos Castro, Joana Marchesini Palma, Bruno Rocha Pribul, Bruno Stéfano Lima Dallago, Bruna Fuga, Margareti Medeiros, Simoneide Souza Titze de Almeida, Hayanna Maria Boaventura da Costa, Dália dos Prazeres Rodrigues, Nilton Lincopán, Simone Perecmanis, Ângela Patrícia Santana,
Listeria monocytogenes and Salmonella spp. are considered important foodborne pathogens that are commonly associated with foods of animal origin. The aim of this study was to perform molecular characterization of L. monocytogenes and Salmonella spp. isolated from biofilms of cattle and poultry slaughterhouses located in the Federal District and State of Goiás, Brazil. Fourteen L. monocytogenes isolates and one Salmonella sp. were detected in poultry slaughterhouses. No isolates were detected in ...
Tópico(s): Food Safety and Hygiene
2021 - Public Library of Science | PLoS ONE
Joana Lemos, Teresa Neuparth, M. Joaquina S. A. Amaral Trigo, Pedro Costa, Daniel Perez Vieira, L.T. Cunha, Francesco Saverio De Ponte, P. S. Costa, Luís F. Metello, António Paulo Carvalho,
Tópico(s): Effects of Radiation Exposure
2016 - Springer Science+Business Media | Bulletin of Environmental Contamination and Toxicology
Paula Diogo, Odete Lemos e Sousa, Joana Rodrigues, Tânia Alexandra de Almeida Martins de Almeida e Silva, Márcia Leandra Ferreira Santos,
To analyze nurses' experiences in the front line of the fight against the COVID-19 pandemic regarding the performance of emotional labor (EL), aiming at its characterization and identification of support strategies and development opportunities of nurses and practices.Qualitative, descriptive, and exploratory study, with content analysis of eleven written narratives and reports from a focus group composed of nurses with experience in caring for patients with COVID-19 from different Hospital Centers ...
Tópico(s): Healthcare professionals’ stress and burnout
2021 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Ana Pinheiro, Fabiana Neves, Ana Lemos de Matos, Joana Abrantes, Wessel van der Loo, Rose G. Mage, Pedro J. Esteves,
Our knowledge of the lagomorph immune system remains largely based upon studies of the European rabbit (Oryctolagus cuniculus), a major model for studies of immunology. Two important and devastating viral diseases, rabbit hemorrhagic disease and myxomatosis, are affecting European rabbit populations. In this context, we discuss the genetic diversity of the European rabbit immune system and extend to available information about other lagomorphs. Regarding innate immunity, we review the most recent ...
Tópico(s): Animal Disease Management and Epidemiology
2015 - Springer Science+Business Media | Immunogenetics
Rahul Mittal, Nathanael Camick, Joana Lemos, Khemraj Hirani,
Type 1 diabetes (T1D) is a complex metabolic autoimmune disorder that affects millions of individuals worldwide and often leads to significant comorbidities. However, the precise trigger of autoimmunity and disease onset remain incompletely elucidated. This integrative perspective article synthesizes the cumulative role of gene-environment interaction in the pathophysiology of T1D. Genetics plays a significant role in T1D susceptibility, particularly at the major histocompatibility complex (MHC) locus ...
Tópico(s): Digestive system and related health
2024 - Frontiers Media | Frontiers in Endocrinology
Joana Lemos, David A. Baidal, Raffaella Poggioli, Virginia Fuenmayor, Carmen Chávez, Ana Alvarez, Elina Linetsky, Franck Mauvais‐Jarvis, Camillo Ricordi, Rodolfo Alejandro,
Abstract Background Islet transplantation (ITx) has proved to be effective in preventing severe hypoglycemia and improving metabolic control in selected subjects with type 1 diabetes. Long-term graft function remains a challenge. Estrogens have been shown to protect β cells from metabolic stresses and improve revascularization of transplanted human islets in the mouse. We aimed to evaluate the influence of sex in allograft survival of ITx recipients. Methods We analyzed a retrospective cohort of ...
Tópico(s): Cannabis and Cannabinoid Research
2021 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Susete Pintéus, Marco F.L. Lemos, Celso Alves, Joana Silva, Rui Pedrosa,
Biofouling is a complex phenomenon that affects all maritime dependent industries. The accumulation of both micro and macro-organisms in immerged structures increases significantly the maintenance expenses, and thus the use of antifouling substances is inevitable. Although with recognized antifouling properties, the available antifouling coatings are known to induce negative impacts in aquatic ecosystems. Therefore, greener alternatives are urgently required. Living underwater, marine organisms ...
Tópico(s): Marine Biology and Ecology Research
2020 - Elsevier BV | The Science of The Total Environment
Tiago Pereira Guedes, Pedro Fragoso, Carolina Lemos, Mónica Garrido, Joana Silva, Daniela Falcão, Luís Maia, Teresa Moreira, José Manuel Ferreira, Isabel Pedroto,
Direct-acting antivirals (DAA) have revolutionized hepatitis C treatment, with high sustained virological response (SVR) rates reported, even in historically difficult-to-treat groups. SVR is associated with a decreased risk of hepatocellular carcinoma (HCC), need for transplantation, and overall and liver-related mortality. Data from real-life cohorts on the medium- to long-term outcomes of patients with advanced liver disease and DAA-induced SVR are still missing.To report and analyze the long-term ...
Tópico(s): Hepatitis B Virus Studies
2019 - Karger Publishers | GE Portuguese Journal of Gastroenterology
Agostinho Lemos, Ana Gomes, Joana B. Loureiro, Pedro Brandão, Andreia Palmeira, Madalena Pinto, Lucı́lia Saraiva, Emı́lia Sousa,
Xanthone scaffold has been regarded as an attractive chemical tool in the search for bioactive molecules with antitumor activity, and in particular two xanthone derivatives, 12-hydroxy-2,2-dimethyl-3,4-dihydro-2H,6H-pyrano [3,2-b]xanthen-6-one (4) and 3,4-dimethoxy-9-oxo-9H-xanthene-1-carbaldehyde (5), were described as a murine double minute 2 (MDM2)-p53 inhibitor and a TAp73 activator, respectively. The xanthone 5 was used as a starting point for the construction of a library of 3,4-dioxygenated xanthones ...
Tópico(s): Ubiquitin and proteasome pathways
2019 - Multidisciplinary Digital Publishing Institute | Molecules
Tiago Ribeiro, Filipa Lemos, Marco Preto, Joana Azevedo, Maria Lígia Sousa, Pedro N. Leão, Alexandre Campos, Stig Linder, Rui Vitorino, Vı́tor Vasconcelos, Ralph Urbatzka,
Portoamides are cyclic peptides produced and released by the cyanobacterial strain Phormidium sp. presumably to interfere with other organisms in their ecosystems ("allelopathy"). Portoamides were previously demonstrated to have an antiproliferative effect on human lung carcinoma cells, but the underlying mechanism of this activity has not been described. In the present work, the effects of portoamides on proliferation were examined in eight human cancer cell lines and two non-carcinogenic cell lines, ...
Tópico(s): bioluminescence and chemiluminescence research
2017 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Daniel Rial, Cristina Lemos, Helena Pinheiro, Joana Mendes Duarte, Francisco Q. Gonçalves, Joana I. Real, Rui Daniel Prediger, Nélio Gonçalves, Catarina A. Gomes, Paula M. Canas, Paula Agostinho, Rodrigo A. Cunha,
Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive neuroplastic processing occurring in defined frontolimbic circuits responsible for emotional processing such as the prefrontal cortex, hippocampus, amygdala and ventral striatum. However, the exact mechanisms controlling synaptic plasticity that are disrupted to trigger depressive conditions have not been elucidated. Since glial cells (astrocytes and ...
Tópico(s): Adenosine and Purinergic Signaling
2016 - Frontiers Media | Frontiers in Cellular Neuroscience
Agostinho Lemos, Miguel Leão, Joana Soares, Andreia Palmeira, Madalena Pinto, Lucı́lia Saraiva, Emı́lia Sousa,
Abstract The growth inhibitory activity of p53 tumor suppressor is tightly regulated by interaction with two negative regulatory proteins, murine double minute 2 (MDM2) and X (MDMX), which are overexpressed in about half of all human tumors. The elucidation of crystallographic structures of MDM2/MDMX complexes with p53 has been pivotal for the identification of several classes of inhibitors of the p53–MDM2/MDMX interaction. The present review provides in silico strategies and screening approaches ...
Tópico(s): Microtubule and mitosis dynamics
2016 - Wiley | Medicinal Research Reviews
Madalena Lemos, Anabela Borges, Joana Teodósio, Paula A. Araújo, Filipe J. Mergulhão, L. F. Melo, Manuel Simões,
Biofilms are a problem to food industries, causing equipment damage, increased energy costs, and food spoilage, and they are a potential harbour of pathogenic microorganisms. Their extreme antimicrobial resistance means that novel control strategies are necessary. Plant secondary metabolites (phyto-chemicals) have demonstrated promising antimicrobial properties when applied against planktonic cells and biofilms. The aim of this study was to test the effectiveness of two phenolic acids: ferulic (FA) ...
Tópico(s): Antimicrobial agents and applications
2013 - Elsevier BV | International Biodeterioration & Biodegradation
Rahul Mittal, Keelin McKenna, Grant Keith, Joana Lemos, Jeenu Mittal, Khemraj Hirani,
Objectives Type 1 diabetes (T1D) has been associated with several comorbidities such as ocular, renal, and cardiovascular complications. However, the effect of T1D on the auditory system and sensorineural hearing loss (SNHL) is still not clear. The aim of this study was to conduct a systematic review to evaluate whether T1D is associated with hearing impairment. Methods The databases PubMed, Science Direct, Scopus, and EMBASE were searched in accordance with the Preferred Reporting Items for Systematic ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2024 - Public Library of Science | PLoS ONE
Joana Roseira, Susana Mão de Ferro, Joana Moleiro, Pedro Currais, Joana Lemos Garcia, Jorge Dionísio, Sofia Ferreira, Isabelle Rosa, Pedro Lage, Ambrus Szanthó, José Duro da Costa, Araída Dias Pereira,
SUMMARY Primary esophageal cancer (EC) frequently presents as a locally advanced disease with airway involvement. Placement of combined esophageal and airway stents has been reported in small series to be an effective palliation strategy. Our aims are to present the largest cohort of EC patients who underwent double stent palliation and to evaluate the safety and efficacy of this approach. Longitudinal cohort study of patients with primary EC undergoing two-stage esophageal and airway stent placement ...
Tópico(s): Esophageal Cancer Research and Treatment
2019 - Oxford University Press | Diseases of the Esophagus
Susete Pintéus, Rodrigues Agnieszka, Joana Silva, Lokman Christien, Lemos Marco, Rui Pedrosa,
... N Rodrigues Joana Silva Christien Lokman Marco F Lemos Rui Pedrosa Google Susete Pinteus Agnieszka N Rodrigues Joana Silva Christien Lokman Marco F Lemos Rui Pedrosa ... N Rodrigues Joana Silva Christien Lokman Marco F Lemos Rui Pedrosa PubMed Susete Pinteus Agnieszka N Rodrigues Joana Silva Christien Lokman Marco F Lemos Rui Pedrosa Related Article in Frontiers Google Scholar ...
Tópico(s): Aquaculture Nutrition and Growth
2016 - Frontiers Media | Frontiers in Marine Science