Joana Rolo, Hermı́nia de Lencastre, Maria Miragaia,
Staphylococcus epidermidis is a harmless commensal, but it can become a human pathogen, mainly in the hospital environment. In order to clarify strategies used by these bacteria to adapt to the hospital environment, we compared the population structure and staphylococcal cassette chromosome mec (SCCmec) content of S. epidermidis from the community and hospital. S. epidermidis were collected from nasal swabs of both healthy military draftees (192 isolates) and patients (94 isolates) recovered in the ...
Tópico(s): Bacterial biofilms and quorum sensing
2012 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Joana Rolo, Hermı́nia de Lencastre, Maria Miragaia,
Previous studies produced evidence that mecA, the determinant of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA), may have originated in the most primitive and widespread animal commensal species—Staphylococcus sciuri. But how the mecA homologue (mecA1/pbpD) was captured from S. sciuri into the staphylococcal cassette chromosome mec (SCCmec) has remained unclear. To understand the role of S. sciuri in the assembly of SCCmec, we screened 118 methicillin-susceptible S. sciuri ...
Tópico(s): Plant-Microbe Interactions and Immunity
2014 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Ana Tavares, Maria Miragaia, Joana Rolo, Catarina Coelho, Hermı́nia de Lencastre, Ca-Mrsa,
Tópico(s): Antibiotic Use and Resistance
2013 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases
Joana César Machado, Paulo Lencastre, Leonor Vacas de Carvalho, Patrício Costa,
In the context of a merger or an acquisition, the management of corporate identity – in particular of corporate brand names and logos – assumes a critical role. The purpose of this article is to provide a better understanding of the corporate brand redeployment decision, considering the reactions of one important stakeholder group – consumers. This study develops a typology of the various corporate identity structures that could be assumed in the context of a brand merger, and analyses how consumers' ...
Tópico(s): Digital Marketing and Social Media
2012 - Palgrave Macmillan | Journal of Brand Management
Produção Nacional
Revisado por pares
Raquel Sá‐Leão, Sofia C. Nunes, António Brito‐Avô, Nelson Frazão, Alexandra S. Simões, M. Inês Crisóstomo, Ana Cristina Paulo, Joana Saldanha, Ilda Santos‐Sanches, H. de Lencastre,
The seven-valent pneumococcal conjugate vaccine (PCV7) has been available in Portugal since June 2001, but is not included in the National Vaccination Plan. Its impact on colonization is unknown. A point-prevalence study to evaluate PCV7 usage was carried out in 2006 among day-care centre attendees from the Lisbon area. Pneumococcal carriage rates, serotypes, and antibiotypes were determined and compared with results from a similar study conducted in 2001 before vaccine approval. In 2001 and 2006, ...
Tópico(s): Respiratory viral infections research
2009 - Elsevier BV | Clinical Microbiology and Infection
Raquel Sá‐Leão, Alexander Tomasz, Ilda Santos‐Sanches, Sónia Nunes, Cristiana Alves, A. Brito Avô, Joana Saldanha, Karl G. Kristinsson, Hermı́nia de Lencastre,
ABSTRACT Characterization by antibiotype of the 1,096 Streptococcus pneumoniae recovered from 2,111 nasopharyngeal samples of children attending 16 day care centers (DCCs) in Lisbon, Portugal, and molecular typing of 413 drug-resistant pneumococci (DRPn) and 89 fully drug-susceptible pneumococci (DSPn) has allowed several conclusions. (i) There was an increase in the frequency of DRPn colonizing children in DCCs from 40% in 1996 to 45% in 1997 to 50% in 1998. (ii) Drug resistance spread by cross-transmission ...
Tópico(s): Streptococcal Infections and Treatments
2000 - American Society for Microbiology | Journal of Clinical Microbiology
Llinos G. Harris, Susan Murray, Ben Pascoe, James E. Bray, Guillaume Méric, Leonardos Mageiros, Thomas S. Wilkinson, Rose E. Jeeves, Holger Rohde, Štefan Schwarz, Hermı́nia de Lencastre, Maria Miragaia, Joana Rolo, Rory Bowden, Keith A. Jolley, Martin Maiden, Dietrich Mack, Samuel K. Sheppard,
Tópico(s): Microbial Metabolism and Applications
2016 - Public Library of Science | PLoS ONE
H. de Lencastre, Karl G. Kristinsson, António Brito‐Avô, Ilda Santos‐Sanches, Raquel Sá‐Leão, Joana Saldanha, ERLA SIGVALDADOTTIR, Sigfús M. Karlsson, DUARTE OLIVEIRA, R. Mato, Marta Aires-de-Sousa, Alexander Tomasz,
In an effort to establish the rate of carriage of antibiotic resistant respiratory pathogens in children attending urban day care centers (DCC) in Portugal, seven DCC in Lisbon were selected for determining the rate of nasopharyngeal colonization of children between the ages of 6 months to 6 years by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Of the 586 children studied between January and March 1996, 47% carried S. pneumoniae, 72% H. influenzae, and 54% M. catarrhalis. ...
Tópico(s): Respiratory and Cough-Related Research
1999 - Mary Ann Liebert, Inc. | Microbial Drug Resistance
Raquel Sá‐Leão, Sónia Nunes, António Brito‐Avô, Carla R. Alves, João André Carriço, Joana Saldanha, Jonas S. Almeida, Ilda Santos‐Sanches, Hermíniade de Lencastre,
Day care centers (DCCs) are unique settings where young children are at increased risk for colonization by pneumococci and Haemophilus influenzae. Although point prevalence studies in DCCs are frequent, only a few longitudinal studies on the dynamics of colonization have been published. We conducted a 1-year longitudinal study with 11 sampling periods on nasopharyngeal carriage of pneumococci and H. influenzae among 47 children who attended a single DCC. All isolates were antibiotyped and genotyped ...
Tópico(s): Respiratory viral infections research
2007 - American Society for Microbiology | Journal of Clinical Microbiology
R. Mato, Ilda Santos‐Sanches, C. Simas, Sofia C. Nunes, João André Carriço, Natacha Gonçalves‐Sousa, Nelson Frazão, Joana Saldanha, António Brito‐Avô, Jonas S. Almeida, Hermı́nia de Lencastre,
A total of 3,539 Streptococcus pneumoniae (Pn) were recovered from 4,969 nasopharyngeal samples of children attending 13 day-care centers (DCCs) located in Lisbon, Portugal, during a surveillance study from January, 2001, through March, 2003, integrated in the European intervention project (EURIS, European Resistance Intervention Study). All Pn isolates were tested for antibiotyping and drug-resistant pneumococci (DRPn) were further tested by serotyping and pulsed-field gel electrophoresis (PFGE). Overall ...
Tópico(s): Respiratory and Cough-Related Research
2005 - Mary Ann Liebert, Inc. | Microbial Drug Resistance
Produção Nacional
Revisado por pares
Sofia C. Nunes, Raquel Sá‐Leão, João André Carriço, Cláudia Alves, R. Mato, A. Brito Avô, Joana Saldanha, Jonas S. Almeida, Ilda Santos‐Sanches, Hermı́nia de Lencastre,
Of the nasopharyngeal cultures recovered from 942 day care center (DCC) attendees in Lisbon, Portugal, 591 (62%) yielded Streptococcus pneumoniae during a surveillance performed in February and March of 1999. Forty percent of the isolates were resistant to one or more antimicrobial agents. In particular, 2% were penicillin resistant and 20% had intermediate penicillin resistance. Multidrug resistance to macrolides, lincosamides, and tetracycline was the most frequent antibiotype (17% of all isolates). ...
Tópico(s): Bacterial Infections and Vaccines
2005 - American Society for Microbiology | Journal of Clinical Microbiology
Joana César Machado, Leonor Vacas de Carvalho, Patrício Costa, Paulo Lencastre,
Purpose In the context of a merger, the management of corporate identity – in particular of corporate names and logos – assumes a critical role. This paper aims to explore how name and logo design characteristics, and specifically figurativeness, influence consumer preferences in the context of a brand merger, in the banking sector. Design/methodology/approach This study develops a typology of the alternative corporate identity structures that may be assumed in the context of a brand merger by drawing ...
Tópico(s): Media, Gender, and Advertising
2012 - Emerald Publishing Limited | Journal of Product & Brand Management
José Neves, Nélia Cunha, André Lencastre, Joana Cabete,
... more papers by this authorAndré Lencastre MD, André Lencastre MD Department of Dermatology and Venereology, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisboa, PortugalSearch for more papers by this authorJoana Cabete MD, Joana Cabete MD Department of Dermatology and Venereology, Hospital ... more papers by this authorAndré Lencastre MD, André Lencastre MD Department of Dermatology and Venereology, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisboa, PortugalSearch for more papers by this authorJoana Cabete MD, Joana Cabete MD Department of Dermatology and Venereology, Hospital ...
Tópico(s): Chemotherapy-related skin toxicity
2019 - Wiley | International Journal of Dermatology
Hermı́nia de Lencastre, Ilda Santos‐Sanches, António Brito‐Avô, Raquel Sá‐Leão, Joana Saldanha, Karl G. Kristinsson, Alexander Tomasz,
Studies on the prevalence of respiratory tract pathogens colonizing the nasopharyngeal flora of children attending day-care centers (DCCs) have been reported in a number of recent publications. Attending day care was shown to be a risk factor for the carriage of antibiotic-resistant strains of pneumococci [1], an observation most likely related to the frequent use of antibiotics in upper respiratory tract infections of children in this age group and also to other epidemiologic features unique to the ...
Tópico(s): Respiratory and Cough-Related Research
1999 - Elsevier BV | Clinical Microbiology and Infection
Joana Cabete, André Lencastre,
... more papers by this authorAndré Lencastre MD, André Lencastre MD Department of Dermatology, Hospital de Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, (Hospital of Santo António dos Capuchos, Lisbon Hospital Center), Lisbon, PortugalSearch for more papers by this author Joana Cabete MD, Joana Cabete MD [email protected] Department of Dermatology, Hospital de Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, (Hospital of Santo António dos Capuchos, Lisbon Hospital Center), Lisbon, PortugalSearch for more papers by this authorAndré Lencastre MD, André Lencastre MD Department of Dermatology, Hospital ...
Tópico(s): Plant Reproductive Biology
2014 - Wiley | International Journal of Dermatology
Llinos G. Harris, Susan Murray, Ben Pascoe, James E. Bray, Guillaume Méric, Leonardos Magerios, Thomas S. Wilkinson, Rose E. Jeeves, Holger Rohde, Štefan Schwarz, Hermı́nia de Lencastre, Maria Miragaia, Joana Rolo, Rory Bowden, Keith A. Jolley, Martin Maiden, Dietrich Mack, Samuel K. Sheppard,
Bacterial species comprise related genotypes that can display divergent phenotypes with important clinical implications. Staphylococcus epidermidis is a common cause of nosocomial infections and, critical to its pathogenesis, is its ability to adhere and form biofilms on surfaces, thereby moderating the effect of the host's immune response and antibiotics. Commensal S. epidermidis populations are thought to differ from those associated with disease in factors involved in adhesion and biofilm accumulation. ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2016 - Public Library of Science | PLoS ONE
Rachel Gordon, Maria Miragaia, Alan Weinberg, Caroline J. Lee, Joana Rolo, Julie Giacalone, Mark S. Slaughter, P. Pappas, Yoshifumi Naka, A. Joseph Tector, Hermı́nia de Lencastre, Franklin D. Lowy,
Background. Little is known about the clonality of Staphylococcus epidermidis in the United States, although it is the predominant pathogen in infections involving prosthetic materials, including ventricular assist devices (VADs). Methods. Seventy-five VAD recipients at 4 geographically diverse US cardiac centers were prospectively followed up to 1 year of VAD support. The anterior nares, sternum, and (future) driveline exit site were cultured for S. epidermidis before VAD insertion and at 7 times ...
Tópico(s): Antifungal resistance and susceptibility
2012 - Oxford University Press | The Journal of Infectious Diseases
Antonio Almeida Silva, Ana Cristina Paulo, João Babo, João Borralho, Catarina Figueiredo, Bruno Gonçalves, João Lança, Mónica Louro, Hermes Morais, Joana Queiroz, Hermı́nia de Lencastre, Raquel Sá‐Leão,
Methicillin-resistant Staphylococcus aureus (MRSA) has long been known as a major cause of hospital-acquired (HA-MRSA) infections worldwide. For the past twenty years, an increasing number of studies have described its emergence in the community as well. In Portugal, a country with a high-prevalence of HA-MRSA, there are only limited data available on the epidemiology of MRSA in the community. We studied the prevalence of S . aureus and MRSA colonization among healthy adults in Portugal. Between February ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2021 - Public Library of Science | PLoS ONE
Nelson Frazão, António Brito‐Avô, C. Simas, Joana Saldanha, R. Mato, Sónia Nunes, Natacha Gonçalves‐Sousa, João André Carriço, Jonas S. Almeida, Ilda Santos‐Sanches, Hermı́nia de Lencastre,
Aims: Prospective study to evaluate the impact of the 7-valent pneumococcal conjugate vaccine (Prevenar) on the nasopharyngeal (NP) carriage of drug-resistant Streptococcus pneumoniae (DRPn), by healthy children attending day-care centers (ages 6 months–6 years). Methods: Vaccinees (238 children) who received vaccine and controls (457 children) were followed for carriage of total S. pneumoniae and DRPn and for the serotypes and genetic backgrounds of DRPn during 6 consecutive sampling periods between ...
Tópico(s): Respiratory viral infections research
2005 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Guillaume Méric, Maria Miragaia, Mark de Been, Koji Yahara, Ben Pascoe, Leonardos Mageiros, Jane Mikhail, Llinos G. Harris, Thomas S. Wilkinson, Joana Rolo, Sarah Lamble, James E. Bray, Keith A. Jolley, William P. Hanage, Rory Bowden, Martin Maiden, Dietrich Mack, Hermı́nia de Lencastre, Edward J. Feil, Jukka Corander, Samuel K. Sheppard,
The opportunistic pathogens Staphylococcus aureus and Staphylococcus epidermidis represent major causes of severe nosocomial infection, and are associated with high levels of mortality and morbidity worldwide. These species are both common commensals on the human skin and in the nasal pharynx, but are genetically distinct, differing at 24% average nucleotide divergence in 1,478 core genes. To better understand the genome dynamics of these ecologically similar staphylococcal species, we carried out ...
Tópico(s): Bacterial Genetics and Biotechnology
2015 - Oxford University Press | Genome Biology and Evolution
Joana Rolo, Maria Miragaia, Agata Turlej-Rogacka, Joanna Empel, Ons Bouchami, Nuno A. Faria, Ana Tavares, Waleria Hryniewicz, Ad C. Fluit, Hermı́nia de Lencastre,
Several studies have addressed the epidemiology of community-associated Staphylococcus aureus (CA-SA) in Europe; nonetheless, a comprehensive perspective remains unclear. In this study, we aimed to describe the population structure of CA-SA and to shed light on the origin of methicillin-resistant S. aureus (MRSA) in this continent.A total of 568 colonization and infection isolates, comprising both MRSA and methicillin-susceptible S. aureus (MSSA), were recovered in 16 European countries, from community ...
Tópico(s): Biochemical and Structural Characterization
2012 - Public Library of Science | PLoS ONE
Joana Rolo, Peder Worning, Jesper Boye Nielsen, Rory Bowden, Ons Bouchami, Peter Damborg, Luca Guardabassi, Vincent Perreten, Alexander Tomasz, Henrik Westh, Hermı́nia de Lencastre, Maria Miragaia,
ABSTRACT Several lines of evidence indicate that the most primitive staphylococcal species, those of the Staphylococcus sciuri group, were involved in the first stages of evolution of the staphylococcal cassette chromosome mec (SCC mec ), the genetic element carrying the β-lactam resistance gene mecA . However, many steps are still missing from this evolutionary history. In particular, it is not known how mecA was incorporated into the mobile element SCC prior to dissemination among Staphylococcus aureus ...
Tópico(s): Microbial Metabolism and Applications
2017 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Joana Rolo, Peder Worning, Jesper Boye Nielsen, Rita G. Sobral, Rory Bowden, Ons Bouchami, Peter Damborg, Luca Guardabassi, Vincent Perreten, Henrik Westh, Alexander Tomasz, Hermı́nia de Lencastre, Maria Miragaia,
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA–an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led to the emergence of methicillin-resistant S. aureus (MRSA) pandemics, responsible for high rates of mortality worldwide. Nonetheless, little is known regarding the origin and evolution of mecA. Different ...
Tópico(s): Antibiotic Resistance in Bacteria
2017 - Public Library of Science | PLoS Genetics
Virgínia Coelho de Sousa, Rita Ramos Pinheiro, Nélia Cunha, André Lencastre, Joana Cabete,
Tópico(s): Skin Diseases and Diabetes
2018 - John Libbey Eurotext | European Journal of Dermatology
Joana Cabete, Ana Fidalgo, André Lencastre, Filipa Diamantino, Alexandre João,
Porokeratosis ptychotropica is a rare variant of porokeratosis that is classically located on the gluteal and perianal regions, seldom extending to the genitalia. The authors report an atypical presentation of porokeratosis ptychotropica and discuss the use of dermoscopy in evaluating this dermatosis. Dermoscopic findings, although not specific to this variant of porokeratosis, are helpful in the differential diagnosis of other genital disorders. Histopathology, through the visualization of multiple ...
Tópico(s): Dermatological and Skeletal Disorders
2015 - Elsevier BV | Anais Brasileiros de Dermatologia
Rita Monteiro, Joana Gama Moreira, João Barroso, José Eduardo Oliveira, Edna Gonçalves,
... of Subcutaneous Levetiracetam in Palliative CareRita Lencastre Monteiro, Joana Gama Moreira, João Barroso, José Eduardo Oliveira, and Edna GonçalvesRita Lencastre MonteiroAddress correspondence to: Rita Lencastre Monteiro, MD, Centro Hospitalar Universitário de Lisboa Central, Hospital Santo Antonio dos Capuchos, Alameda Santo António dos Capuchos, Lisboa 1150-199, Portugal E-mail Address: mritalmonteiro@gmail.comCentro Hospitalar Universitário de Lisboa Central, Alameda Santo António dos Capuchos, Lisboa, Portugal.Search for more papers by this author, Joana Gama MoreiraCavado I, Cávado I, Agrupamento de Centros ...
Tópico(s): Palliative Care and End-of-Life Issues
2022 - Mary Ann Liebert, Inc. | Journal of Palliative Medicine
Margarida Moura Valejo Coelho, Virgínia Coelho de Sousa, Joana Cabete, André Lencastre,
Tópico(s): Nonmelanoma Skin Cancer Studies
2016 - John Libbey Eurotext | European Journal of Dermatology
Bruno Duarte, Nélia Cunha, André Lencastre, Joana Cabete,
Tópico(s): Colorectal and Anal Carcinomas
2020 - Elsevier BV | Actas Dermo-Sifiliográficas
André Lencastre, Joana Cabete, Alexandre João, Pedro Farinha, Gilda Aparecida Ferreira, Sara Lestre,
Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node ...
Tópico(s): CAR-T cell therapy research
2013 - Elsevier BV | Anais Brasileiros de Dermatologia
André Lencastre, Joana Cabete, Maria Margarida Apetato,
An 83 year-old man was observed for an 8 year-long pruritic, erythematous plaque of the left axilla. He had been continuously medicated with topical antifungals and steroids with occasional symptomatic relief, but with disease progression. After a clinical and histological diagnosis of Extramammary Paget's Disease, a total excision with wide margins was performed. He remains disease-free 12 months after surgery. We report this rare presentation of Extramammary Paget's Disease on a male patient.
Tópico(s): Advanced Antenna and Metasurface Technologies
2013 - Elsevier BV | Anais Brasileiros de Dermatologia