Ángeles C. López-Tarrida, Rocío de Diego‐Cordero, Joaquín Salvador Lima‐Rodríguez,
It is becoming increasingly important to address the spiritual dimension in the integral care of the people in order to adequately assist them in the processes of their illness and healing. Considering the spiritual dimension has an ethical basis because it attends to the values and spiritual needs of the person in clinical decision-making, as well as helping them cope with their illness. Doctors, although sensitive to this fact, approach spiritual care in clinical practice with little rigour due ...
Tópico(s): Palliative Care and End-of-Life Issues
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Indira García‐Cordero, Joaquín Migeot, Sol Fittipaldi, Alexia Aquino, Cecilia González Campo, Adolfo M. García, Agustín Ibáñez,
Metacognition (monitoring) of emotion recognition is fundamental for social interactions. Correct recognition of and confidence in the emotional meaning inferred from others' faces are fundamental for guiding and adjusting interpersonal behavior. Yet, although emotion recognition impairments are well documented across neurodegenerative diseases, the role of metacognition in this domain remains poorly understood. Here, we evaluate multimodal neurocognitive markers of metacognition in 83 subjects, ...
Tópico(s): Memory and Neural Mechanisms
2021 - Elsevier BV | Cortex
María José González‐Serna, Pedro J. Cordero, Joaquín Ortego,
Abstract Inferring the processes underlying spatial patterns of genomic variation is fundamental to understand how organisms interact with landscape heterogeneity and to identify the factors determining species distributional shifts. Here, we use genomic data (restriction site‐associated DNA sequencing) to test biologically informed models representing historical and contemporary demographic scenarios of population connectivity for the Iberian cross‐backed grasshopper Dociostaurus hispanicus , a species ...
Tópico(s): Wildlife Ecology and Conservation
2019 - Wiley | Molecular Ecology
Víctor Noguerales, Pedro J. Cordero, Joaquín Ortego,
Although resolving phylogenetic relationships and establishing species limits are primary goals of systematics, these tasks remain challenging at both conceptual and analytical levels. Here, we integrated genomic and phenotypic data and employed a comprehensive suite of coalescent-based analyses to develop and evaluate competing phylogenetic and species delimitation hypotheses in a recent evolutionary radiation of grasshoppers (Chorthippus binotatus group) composed of two species and eight putative ...
Tópico(s): Orthoptera Research and Taxonomy
2018 - Wiley | Molecular Ecology
Vicente García‐Navas, Víctor Noguerales, Pedro J. Cordero, Joaquín Ortego,
Sexual size dimorphism (SSD) is widespread and variable in nature. Although female-biased SSD predominates among insects, the proximate ecological and evolutionary factors promoting this phenomenon remain largely unstudied. Here, we employ modern phylogenetic comparative methods on eight subfamilies of Iberian grasshoppers (85 species) to examine the validity of different models of evolution of body size and SSD and explore how they are shaped by a suite of ecological variables (habitat specialization, ...
Tópico(s): Species Distribution and Climate Change
2017 - Oxford University Press | Journal of Evolutionary Biology
Víctor Noguerales, Pedro J. Cordero, Joaquín Ortego,
Understanding the underlying processes shaping spatial patterns of genetic structure in free-ranging organisms is a central topic in evolutionary biology. Here, we aim to disentangle the relative importance of neutral (i.e. genetic drift) and local adaptation (i.e. ecological divergence) processes in the evolution of spatial genetic structure of the Morales grasshopper (Chorthippus saulcyi moralesi), a narrow-endemic taxon restricted to the Central Pyrenees. More specifically, we analysed range-wide ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2016 - Springer Science+Business Media | BMC Evolutionary Biology
Víctor Noguerales, Vicente García‐Navas, Pedro J. Cordero, Joaquín Ortego,
The integration of genetic information with ecological and phenotypic data constitutes an effective approach to gain insight into the mechanisms determining interpopulation variability and the evolutionary processes underlying local adaptation and incipient speciation. Here, we use the Pyrenean Morales grasshopper (Chorthippus saulcyi moralesi) as study system to (i) analyse the relative role of genetic drift and selection in range-wide patterns of phenotypic differentiation and (ii) identify the potential ...
Tópico(s): Plant and animal studies
2016 - Oxford University Press | Journal of Evolutionary Biology
María José González‐Serna, Pedro J. Cordero, Joaquín Ortego,
Inferring the demographic history of species is fundamental for understanding their responses to past climate/landscape alterations and improving our predictions about the future impacts of the different components of ongoing global change. Estimating the time-frame at which population fragmentation took place is also critical to determine whether such process was shaped by ancient events (e.g. past climate/geological changes) or if, conversely, it was driven by recent human activities (e.g. habitat ...
Tópico(s): Wildlife Ecology and Conservation
2018 - Nature Portfolio | Scientific Reports
Joaquin Cordero‐Martínez, Tania Reyes‐Miguel, Lorena Rodríguez‐Páez, Leticia Garduño‐Siciliano, Deneb Maldonado‐García, Ana L. Roa‐Espitia, Enrique O. Hernández‐González,
Abstract Ca 2+ ‐activated Cl − channels (CaCCs) are anionic channels that regulate many important physiological functions associated with chloride and calcium flux in some somatic cells. The molecular identity of CaCCs was revealed to be TMEM16A and TMEM16B (also known as Anoctamin or ANO1 and ANO2, respectively) in all eukaryotes. A recent study suggests the presence of TMEM16A in human sperm and a relationship with the rhZP‐induced acrosome reaction. However, to the best of our knowledge, little is ...
Tópico(s): Neuroendocrine regulation and behavior
2018 - Wiley | Journal of Cellular Biochemistry
María Luz Alonso-Álvarez, José Cordero-Guevara, Joaquín Téran‐Santos, Mónica González, María José Jurado, Jaime Corral‐Peñafiel, Joaquín Durán‐Cantolla, David Gozal, David Gozal,
Introduction:Obesity in children is assumed to serve as a major risk factor in pediatric obstructive sleep apnea syndrome (OSAS). However, the prevalence of OSAS in otherwise healthy obese children from the community is unknown.
Tópico(s): Cardiovascular and Diving-Related Complications
2014 - Oxford University Press | SLEEP
Alex Gileles‐Hillel, María Luz Alonso-Álvarez, David Gozal, Eduard Peris, José Cordero-Guevara, Joaquín Téran‐Santos, Mónica González, María José Jurado, Jaime Corral‐Peñafiel, Joaquín Durán‐Cantolla, David Gozal,
Introduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. Aim. To examine the levels of inflammatory markers in obese community-dwelling children with OSA, as compared to no-OSA, and their association with clinical and polysomnographic (PSG) variables. Methods. In this cross-sectional, prospective multicenter study, healthy obese ...
Tópico(s): Sleep and related disorders
2014 - Hindawi Publishing Corporation | Mediators of Inflammation
Mar Cordero-Alba, Joaquín Bernal-Bayard, Francisco Ramos‐Morales,
ABSTRACT Virulence-related type III secretion systems are present in many Gram-negative bacterial pathogens. These complex devices translocate proteins, called effectors, from the bacterium into the eukaryotic host cell. Here, we identify the product of srfJ , a Salmonella enterica serovar Typhimurium gene regulated by SsrB, as a new substrate of the type III secretion system encoded by Salmonella pathogenicity island 2. The N-terminal 20-amino-acid segment of SrfJ was recognized as a functional secretion ...
Tópico(s): Escherichia coli research studies
2012 - American Society for Microbiology | Journal of Bacteriology
Lorena Rodríguez‐Páez, Miguel Angel Chena-Taboada, Arturo Cabrera-Hernández, Joaquin Cordero‐Martínez, Carlos Wong,
We performed kinetic studies to determine whether oxamate analogues are selective inhibitors of LDH-C4, owing to their potential usefulness in fertility control and treatment of some cancers. These substances were shown to be competitive inhibitors of LDH isozymes and are able to discriminate among subtle differences that differentiate the active sites of LDH-A4, LDH-B4 and LDH-C4. N-Ethyl oxamate was the most potent inhibitor showing the highest affinity for LDH-C4. However, N-propyl oxamate was ...
Tópico(s): Aldose Reductase and Taurine
2011 - Taylor & Francis | Journal of Enzyme Inhibition and Medicinal Chemistry
Carmen Sandi, María I. Cordero, José Joaquín Merino, Nyika D. Kruyt, Ciaran M. Regan, Keith J. Murphy,
The polysialylated neural cell adhesion molecule (PSA-NCAM) has been implicated in activity-dependent synaptic remodeling and memory formation. Here, we questioned whether training-induced modulation of PSA-NCAM expression might be related to individual differences in spatial learning abilities. At 12 h posttraining, immunohistochemical analyses revealed a learning-induced up-regulation of PSA-NCAM in the hippocampal dentate gyrus that was related to the spatial learning abilities displayed by rats ...
Tópico(s): Memory and Neural Mechanisms
2004 - Cold Spring Harbor Laboratory Press | Learning & Memory
Eduardo García-Cimbrelo, Ana Cruz-Pardos, José Cordero‐Ampuero, Joaquín Sánchez‐Sotelo,
A total of 67 low-friction arthroplasties were performed from 1971 through 1978 in patients <40 years old and followed an average of 21.7 years. There have been 33 cup loosenings and 17 stem loosenings. The average rate of wear of the cup was 0.12 mm/y for the entire series and 0.16 mm/y for the revised cups. Although the preoperative diagnosis leading to low-friction arthroplasty commonly reflected some deficiency in bone structure, particularly in the acetabulum, there were no primary osteoarthrosis ...
Tópico(s): Orthopedic Infections and Treatments
2000 - Elsevier BV | The Journal of Arthroplasty
Verónica Herrera-Mayorga, Edgar E. Lara‐Ramírez, Karla Fabiola Chacón-Vargas, Charmina Aguirre-Alvarado, Lorena Rodríguez‐Páez, Verónica Alcántara‐Farfán, Joaquin Cordero‐Martínez, Benjamín Nogueda‐Torres, Francisco Reyes‐Espinosa, Virgilio Bocanegra‐García, Gildardo Rivera,
Chagas disease (CD), or American trypanosomiasis, causes more than 10,000 deaths per year in the Americas. Current medical therapy for CD has low efficacy in the chronic phase of the disease and serious adverse effects; therefore, it is necessary to search for new pharmacological treatments. In this work, the ZINC15 database was filtered using the N-acylhydrazone moiety and a subsequent structure-based virtual screening was performed using the cruzain enzyme of Trypanosoma cruzi to predict new potential ...
Tópico(s): Synthesis and Biological Evaluation
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Vicente García‐Navas, Víctor Noguerales, Pedro J. Cordero, Joaquín Ortego,
The combination of model-based comparative techniques, disparity analyses and ecomorphological correlations constitutes a powerful method to gain insight into the evolutionary mechanisms that shape morphological variation and speciation processes. In this study, we used a time-calibrated phylogeny of 70 Iberian species of short-horned grasshoppers (Acrididae) to test for patterns of morphological disparity in relation to their ecology and phylogenetic history. Specifically, we examined the role of ...
Tópico(s): Evolution and Paleontology Studies
2017 - Springer Science+Business Media | BMC Evolutionary Biology
Víctor Noguerales, Pedro J. Cordero, Joaquín Ortego,
Understanding the consequences of past environmental changes on the abiotic and biotic components of the landscape and deciphering their impacts on the demographic trajectories of species is a major issue in evolutionary biogeography. In this study, we combine nuclear and mitochondrial genetic data to study the phylogeographical structure and lineage-specific demographic histories of the scrub-legume grasshopper (Chorthippus binotatus binotatus), a montane taxon distributed in the Iberian Peninsula ...
Tópico(s): Species Distribution and Climate Change
2017 - Elsevier BV | Molecular Phylogenetics and Evolution
Danelia Ramírez‐Ramírez, Monica L. Salgado‐Lucio, Ana L. Roa‐Espitia, Reyna Fierro, Humberto González‐Márquez, Joaquin Cordero‐Martínez, Enrique O. Hernández‐González,
Abstract Actin cytoskeleton remodeling is a critical process for the acquisition of fertilizing capacity by spermatozoa during capacitation. However, the molecular mechanism that regulates this process has not been fully elucidated. In somatic cells, Ras‐related C3 botulinum toxin substrate 1 protein (Rac1) promotes the polymerization of actin by participating in the modeling of two structures: lamellipodia and adhesion complexes linked with the plasma membrane. Rac1 is expressed in mammalian spermatozoa; ...
Tópico(s): Erythrocyte Function and Pathophysiology
2019 - Wiley | Journal of Cellular Biochemistry
Víctor Noguerales, Pedro J. Cordero, Joaquín Ortego,
Understanding the processes underlying spatial patterns of genetic diversity and structure of natural populations is a central topic in evolutionary biogeography. In this study, we combine data on ancient and contemporary landscape composition to get a comprehensive view of the factors shaping genetic variation across the populations of the scrub-legume grasshopper (Chorthippus binotatus binotatus) from the biogeographically complex region of southeast Iberia. First, we examined geographical patterns ...
Tópico(s): Plant and animal studies
2017 - Wiley | Ecology and Evolution
Pedro J. Cordero, Vicenta Llorente, Pau Cordero, Joaquín Ortego,
Recognizing taxonomic units in the field complement classical museum taxonomy. It contributes to geographical distribution assessment making possible the recognition of conservation status of conflictive and similar species. In this paper, we provide unambiguous field characters distinguishing two similar species of Oecanthus in Southern Europe: Oecanthus dulcisonans Gorochov and O. pellucens (Scopoli) that are frequently misidentified. Whereas O. dulcisonans is a southern rare species with an uncertain ...
Tópico(s): Plant Parasitism and Resistance
2009 - Q15088586 | Zootaxa
Joaquin Cordero‐Martínez, Charmina Aguirre-Alvarado, Carlos Wong, Lorena Rodríguez‐Páez,
The present study evaluates the effect of oxamate derivatives (N-ethyl, N-propyl, N-butyl oxamates) on functional murine sperm parameters, towards a new male non-hormonal contraceptive. These derivatives are selective inhibitors of lactate dehydrogenase-C4 (LDH-C4). LDH-C4 is a sperm-specific enzyme that plays an important role in ATP production for maintaining progressive motility as well as to induce capacitation and hyperactivation. The results demonstrate that all oxamate derivatives selectively ...
Tópico(s): Reproductive Biology and Fertility
2014 - Taylor & Francis | Systems Biology in Reproductive Medicine
Tania Ángeles-Floriano, Ana L. Roa‐Espitia, Rafael Baltiérrez‐Hoyos, Joaquin Cordero‐Martínez, Guillermo Elizondo, Enrique O. Hernández‐González,
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the toxicity of a variety of environmental chemicals. The absence of this receptor causes serious reproductive complications. Ahr-knockout (Ahr-KO) male mice, for example, are considerably less fertile: Half of the few spermatozoa they produce exhibit morphological alterations, and those with typical morphology may have pathologic modifications. We therefore investigated the consequences of AHR loss on capacitation ...
Tópico(s): Reproductive biology and impacts on aquatic species
2016 - Wiley | Molecular Reproduction and Development
Susana González-Rámila, Beatriz Sarriá, Miguel A. Seguido, Joaquín García-Cordero, Raquel Mateos, Laura Bravo,
Abstract Purpose This study aimed to assess the effect of dietary consumption of olive pomace oil (OPO) on blood lipids (primary outcome) and other cardiovascular disease (CVD) risk factors (blood pressure, inflammation and endothelial function as secondary outcomes). Methods A randomized, controlled, blind, crossover intervention was carried out in healthy and at-risk (hypercholesterolemic) subjects. Participants consumed daily 45 g of OPO or high-oleic acid sunflower oil (HOSO) as control oil during ...
Tópico(s): Cholesterol and Lipid Metabolism
2022 - Springer Science+Business Media | European Journal of Nutrition
Susana González-Rámila, Raquel Mateos, Joaquín García-Cordero, Miguel A. Seguido, Laura Bravo, Beatriz Sarriá,
Olive pomace oil (OPO) is mainly a source of monounsaturated fat together with a wide variety of bioactive compounds, such as triterpenic acids and dialcohols, squalene, tocopherols, sterols and aliphatic fatty alcohols. To date, two long-term intervention studies have evaluated OPO’s health effects in comparison with high oleic sunflower oil (HOSO, study-1) and sunflower oil (SO, study-2) in healthy and cardiovascular risk subjects. The present study integrates the health effects observed with the ...
Tópico(s): Cholesterol and Lipid Metabolism
2022 - Multidisciplinary Digital Publishing Institute | Foods
Joaquín García-Cordero, Alicia Pino, Constanza Cuevas, Verónica Puertas‐Martín, Ricardo San Román, Sonia de Pascual‐Teresa,
In recent decades, the elderly population has increased at higher rates than any other population group, resulting in an increase in age-related diseases such as neurodegenerative and cognitive impairment. To address this global health problem, it is necessary to search for new dietary strategies that can prevent the main neurocognitive problems associated with the ageing process. Therefore, the aim of the present study was to analyze the effect of cocoa flavanols and red berry anthocyanins on brain- ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2021 - Multidisciplinary Digital Publishing Institute | Nutrients
Joaquín G. Cordero, Ramón García‐Escudero, Jesús Ávila, Ricardo Gargini, Vega García‐Escudero,
Alzheimer’s disease is a proteinopathy characterized by accumulation of hyperphosphorylated Tau and β ‐amyloid. Autophagy is a physiological process by which aggregated proteins and damaged organelles are eliminated through lysosomal digestion. Autophagy deficiency has been demonstrated in Alzheimer’s patients impairing effective elimination of aggregates and damaged mitochondria, leading to their accumulation, increasing their toxicity and oxidative stress. In the present study, we demonstrated ...
Tópico(s): Phytochemicals and Antioxidant Activities
2018 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Kerri Muller, Judy A. Stamps, V. V. Krishnan, Neil H. Willits,
... org/10.1007/s00338-010-0642-1Gustau Calabuig, Joaquín Ortego, Pedro J. Cordero, José Miguel Aparicio Colony foundation in the lesser ... doi.org/10.1371/journal.pone.0003930Gustau Calabuig, Joaquín Ortego, Pedro J. Cordero, José Miguel Aparicio Causes, consequences and mechanisms of ... doi.org/10.1655/08-020R1.1Gustau Calabuig, Joaquín Ortego, José Miguel Aparicio, Pedro J. Cordero Public information in selection of nesting colony by ...
Tópico(s): Plant and animal studies
1997 - University of Chicago Press | The American Naturalist
Guadalupe Elizabeth Jiménez Gutierrez, Fabiola Jiménez, Luis G. Muñoz, Y. S. Tapia-Guerrero, Nadia Mireya Murillo-Melo, José Melesio Cristóbal-Luna, Norberto Leyva García, Joaquín Cordero‐Martínez, Jonathan J. Magaña,
Polyamines (Pas) are short molecules that exhibit two or three amine groups that are positively charged at a physiological pH. These small molecules are present in high concentrations in a wide variety of organisms and tissues, suggesting that they play an important role in cellular physiology. Polyamines include spermine, spermidine, and putrescine, which play important roles in age-related diseases that have not been completely elucidated. Aging is a natural process, defined as the time-related ...
Tópico(s): Pancreatic function and diabetes
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Raquel Mateos, Joaquín García-Cordero, Laura Bravo, Beatriz Sarriá,
Obesity and its associated comorbidities are a major public health concern worldwide. Reduced energy intake and increased physical activity interventions have limited success in the long term. Nutraceuticals might be an alternative means to help lose weight and reduce obesity-associated cardiometabolic risk factors without changes in the habitual diet. The objective of the present study was to comparatively evaluate the efficiency of nutraceuticals based on the combination of a decaffeinated green ...
Tópico(s): Diet and metabolism studies
2021 - Royal Society of Chemistry | Food & Function