Yaohua Yang, Xiang Shu, Xiao‐Ou Shu, Manjeet K. Bolla, Sun‐Seog Kweon, Qiuyin Cai, Kyriaki Michailidou, Qin Wang, Joe Dennis, Boyoung Park, Keitaro Matsuo, Ava Kwong, Sue K. Park, Anna H. Wu, Soo‐Hwang Teo, Motoki Iwasaki, Ji‐Yeob Choi, Jingmei Li, Mikael Hartman, Chen‐Yang Shen, Kenneth Muir, Artitaya Lophatananon, Bingshan Li, Wanqing Wen, Yu-Tang Gao, Yong-Bing Xiang, Kristan J. Aronson, John J. Spinell, Manuela Gago‐Dominguez, Esther M. John, Allison W. Kurian, Jenny Chang‐Claude, Shou-Tung Chen, Thilo Dörk, D. Gareth Evans, Marjanka K. Schmidt, Min‐Ho Shin, Graham G. Giles, Roger L. Milne, Jacques Simard, Michiaki Kubo, Peter Kraft, Daehee Kang, Douglas F. Easton, Wei Zheng, Jirong Long,
BackgroundWe previously conducted a systematic field synopsis of 1059 breast cancer candidate gene studies and investigated 279 genetic variants, 51 of which showed associations. The major limitation of this work was the small sample size, even pooling data from all 1059 studies. Thereafter, genome-wide association studies (GWAS) have accumulated data for hundreds of thousands of subjects. It's necessary to re-evaluate these variants in large GWAS datasets.MethodsOf these 279 variants, data were ...
Tópico(s): Nutrition, Genetics, and Disease
2019 - Elsevier BV | EBioMedicine