David R. Holmes, Sameer Mehta, Charles J. George, James R. Margolis, Martin B. Leon, J M Isner, John A. Bittl, Spencer B. King, Robert Siegel, Michael H. Sketch, Michael J. Cowley, Gary S. Roubin, Jeffery Brinker, Paul Overlie, James E. Tcheng, Timothy A. Sanborn, Frank Litvack,
In the New Approaches to Coronary Intervention (NACI) registry, 887 patients were electively treated with excimer laser coronary angioplasty (ELCA) for coronary artery disease. The Advanced Interventional System (AIS) system was used in 487 cases; the Spectranetics system, in 400. The mean age was 63.4 years. Most patients had unstable angina (60.3%); 43.7% had a prior myocardial infarction; and 18.6% were high risk or inoperable patients. Mean ejection fraction was 55.4%. A total of 1,000 lesions were ...
Tópico(s): Cardiac and Coronary Surgery Techniques
1997 - Elsevier BV | The American Journal of Cardiology
Jeffrey M. Isner, John S. Macdonald, Philip S. Schein,
Spontaneous peritonitis in adults has not been previously reported to occur in association with ascites of neoplastic origin. We report a patient with metastatic gastric adenocarcinoma in whom spontaneous streptococcus pneumonia peritonitis occurred as a terminal event. Massive metastases may have resulted in significant loss of the hepatic reticuloendothelial system and impaired the capability of the liver to function as an effective bacterial filter, predisposing the patient to bacterial peritonitis.
Tópico(s): Pancreatic and Hepatic Oncology Research
1977 - Wiley | Cancer
Deeb N. Salem, Marvin A. Konstam, Jeffrey M. Isner, John D. Bonin,
The ECG and hemodynamic responses to a standard ionic radiographic contrast agent (diatrizoate) were measured and compared to those induced by iopamidol, a newly developed nonionic agent, during left ventriculography. Studies were performed using randomized double-blind techniques in 46 patients with suspected coronary artery disease who were scheduled for cardiac catheterization. A nuclear probe was used to measure left ventricular ejection fraction and relative ventricular volume before and immediately ...
Tópico(s): Advanced MRI Techniques and Applications
1986 - Elsevier BV | American Heart Journal
Leslie T. Cooper, William R. Hiatt, Mark A. Creager, Judith G. Regensteiner, Ward Casscells, Jeffrey M. Isner, John P. Cooke, Alan T. Hirsch,
Intermittent claudication is the most common symptom of peripheral arterial disease (PAD), in part due to an inadequate rise in limb blood flow with exercise. Claudication causes a severe impairment in functional capacity and quality of life in over 3 million Americans. Basic fibroblast growth factor (bFGF) stimulates angiogenesis in vivo and improves limb blood flow in several animal models of hindlimb ischemia. However, the relative safety and efficacy of angiogenic molecules in the treatment of ...
Tópico(s): Lymphatic System and Diseases
2001 - SAGE Publishing | Vascular Medicine
Anthony Winston, John P. Bederka, William G. Isner, Peter C. Juliano, John C. Sharp,
... Tautomerism1aAnthony Winston, John P. M. Bederka, William G. Isner, Peter C. Juliano, and John C. SharpCite this: J. Org. Chem. 1965, 30, ...
Tópico(s): Synthesis and Catalytic Reactions
1965 - American Chemical Society | The Journal of Organic Chemistry
... Fortran programming methodology based on data abstraction Author: John F. Isner National Geodetic Survey, Rockville, MD National Geodetic Survey, ...
Tópico(s): Advanced Computational Techniques and Applications
1982 - Association for Computing Machinery | Communications of the ACM
... have happened in professional tennis matches. In 2010, John Isner and Nicolas Mahut played a final set of ...
Tópico(s): Sports Analytics and Performance
2013 - Taylor & Francis | International Journal of Performance Analysis in Sport
Howard C. Herrmann, Krishnamurthy Ramaswamy, Jeffrey M. Isner, Ted Feldman, John D. Carroll, Augusto D. Pichard, Thomas M. Bashore, Gerald Dorros, G.Ali Massumi, Ponnambalam Sundram, Jonathan M. Tobis, Robert C. Feldman, Stephen Ramee,
Clinical trials with the Inoue mitral valvotomy balloon have recently begun in the United States. We assessed the effects of 17 demographic, echocardiographic, procedural, and hemodynamic variables on the immediate results, complications, and short-term follow-up of 200 patients in 15 centers undergoing valvotomy with this device. The study population had a mean age +/- SD of 53 +/- 15 years, and the total echocardiographic score was 7.2 +/- 2.4. Valvotomy was technically successful in 96.5% of procedures and ...
Tópico(s): Infective Endocarditis Diagnosis and Management
1992 - Elsevier BV | American Heart Journal
John A. Spittell, Mark A. Creager, Gerald Dorros, Jeffrey M. Isner, Navin C. Nanda, John L. Ochsner, Lewis Wexler, Jess R. Young,
Tópico(s): Vascular Procedures and Complications
1993 - Elsevier BV | Journal of the American College of Cardiology
John A. Spittell, Mark A. Creager, Gerald Dorros, Jeffrey M. Isner, Navin C. Nanda, John L. Ochsner, Lewis Wexler, Jess R. Young,
Each trainee in vascular medicine must be eligible for the board certification examination of the American Board of Internal Medicine or its equivalent. Training faculty, preferably at least two members, should meet the qualifications and training requirements described in this report. They must be dedicated, effective teachers and should spend most of their time in research, education and patient care related to peripheral vascular diseases. A curriculum of training should be established. Faculty ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
1993 - Elsevier BV | Journal of the American College of Cardiology
Jeffrey M. Isner, Deeb N. Salem, John S. Banas, Herbert J. Levine,
Tópico(s): Congenital Heart Disease Studies
1981 - Elsevier BV | American Heart Journal
... citing heat exhaustion or cramping. In the quarterfinals, John Isner went through 11 shirts and lost up to 10 pounds in a four-set loss, while John Millman, in another loss, changed his entire wardrobe — ...
Tópico(s): High Altitude and Hypoxia
2018 - Lippincott Williams & Wilkins | Current Sports Medicine Reports
Marvin A. Konstam, Deeb N. Salem, Jeffrey M. Isner, Michael R. Zile, Paul Kahn, John D. Bonin, Steven R. Cohen, Herbert J. Levine,
Tópico(s): Cardiovascular Function and Risk Factors
1984 - Elsevier BV | The American Journal of Cardiology
Jeffrey M. Isner, Saurabh K. Chokshi, Anthony DeFranco, John Braimen, Geralyn A. Slovenkai,
Preliminary findings from clinical trials of percutaneous balloon aortic valvuloplasty and intraoperative debridement of calcific deposits in patients with aortic stenosis have suggested that calcified, congenitally bicuspid aortic valves may be less amenable to these techniques than are calcified tricuspid aortic valves. Accordingly, we evaluated the histoarchitecture of calcific deposits in 30 operatively excised aortic valves. Light microscopic sections taken through the calcified aortic valve ...
Tópico(s): Infective Endocarditis Diagnosis and Management
1990 - Elsevier BV | Journal of the American College of Cardiology
Jeffrey M. Isner, Barbara L. Carter, Mark S. Bankoff, John O. Pastore, Krishnamurthy Ramaswamy, Keith P. W. J. McAdam, Deeb N. Salem,
The heart and mediastinal structures can be overlooked at CT pulmonary angiogram (CTPA). This pictorial review will demonstrate the features of cardiac disease that may be evident on a CTPA.CTPA allows assessment of not only the pulmonary arteries for embolism, but also of the bronchi, lung parenchyma, mediastinum and heart. Co-existent underlying or incidental cardiac disease is often present. Potentially life-threatening alternative diagnoses in a patient with chest symptoms can be reliably identified. ...
Tópico(s): Cardiomyopathy and Myosin Studies
1983 - Elsevier BV | American Heart Journal
John T. Harrington, Jeffrey M. Isner, Jerome P. Kassirer,
1982 - Elsevier BV | The American Journal of Medicine
Ted Feldman, John D. Carroll, Jeffrey M. Isner, Robert J. Chisholm, David R. Holmes, Ali Massumi, Augusto D. Pichard, Howard C. Herrmann, Simon H. Stertzer, William W. O’Neill,
BACKGROUND The effect of valve deformity and patient age adversely affect the results of percutaneous transvenous mitral commissurotomy (PTMC) with conventional balloons. METHODS AND RESULTS These factors were characterized after PTMC with the Inoue balloon. The increases in mitral valve area and mitral regurgitation after the procedure were evaluated comparing echocardiographic score of 8 or less versus more than 8, age of less than 60 versus age of 60 years or more, and age of less than 70 versus ...
Tópico(s): Cardiovascular Function and Risk Factors
1992 - Lippincott Williams & Wilkins | Circulation
Dirk Hausmann, Raimund Erbel, M.-J. Alibelli-Chemarin, Wolfgang Boksch, Eugene A. Caracciolo, Joel Cohn, Stephen C. Culp, Werner G. Daniel, Ivan De Scheerder, Carlo DiMario, James J. Ferguson, Peter J. Fitzgerald, Guy Friedrich, Junbo Ge, G Görge, Peter Hanrath, John McB. Hodgson, Jeffrey M. Isner, Suresh Jain, Willibald Maier-Rudolph, Michael Mooney, Jeffrey W. Moses, Harald Mudra, Fausto J. Pinto, Richard W. Smalling, J. David Talley, Jonathan M. Tobis, Paul D. Walter, Franz Weidinger, Gerald S. Werner, Alan C. Yeung, Paul G. Yock,
Background Intracoronary ultrasound (ICUS) is increasingly used in clinical practice to study the natural history of coronary artery disease and to assess the effects of intracoronary, catheter-based interventions. However, the risk associated with the procedure is not well documented. Methods and Results ICUS studies performed in 28 centers were retrospectively included; these centers agreed to contribute to the study among a total of 60 centers initially invited. Among the 2207 ICUS studies, 505 ( ...
Tópico(s): Cardiovascular Issues in Pregnancy
1995 - Lippincott Williams & Wilkins | Circulation
Jeffrey M. Isner, Douglas W. Losordo, Kenneth Rosenfield, Krishnaswamy Ramaswamy, Susan Kelly, John O. Pastore, Bernard D. Kosowsky,
A catheter-based intravascular ultrasound transducer was used to study aortic valve morphology in adults with calcific aortic stenosis. Examination of 14 postmortem specimens disclosed that intravascular ultrasound consistently identified the number of cusps or the presence of a calcified median raphe in the conjoined cusp, or both, and thereby distinguished a calcified bicuspid from a calcified tricuspid aortic valve. These postmortem findings were then employed to identify valvular morphology ...
Tópico(s): Cardiovascular Function and Risk Factors
1990 - Elsevier BV | Journal of the American College of Cardiology
John A. Bittl, T A Sanborn, David E. Yardley, James E. Tcheng, Jeffrey M. Isner, Saurabh K. Chokshi, Bradley H. Strauss, George S. Abela, Paul D. Walter, Mark Schmidhofer, John Power,
A total of 495 patients underwent treatment with excimer laser angioplasty for 545 saphenous vein graft stenoses. Clinical success was achieved in 455 of 495 patients (92%), as indicated by < or = 50% residual stenosis at every target lesion and no complication during hospitalization. At least 1 in-hospital complication occurred in 30 of 495 patients (6.1%): death (1.0%), bypass surgery (0.6%), and Q-wave (2.4%) or non-Q-wave (2.2%) myocardial infarction. Relative risk analysis showed that ostial lesions ( ...
Tópico(s): Cardiac and Coronary Surgery Techniques
1994 - Elsevier BV | The American Journal of Cardiology
F. David Fortuin, Peter R. Vale, Douglas W. Losordo, James F. Symes, Giacomo A. DeLaria, Jeffrey Tyner, Gary L. Schaer, Robert March, R. Jeffrey Snell, Timothy D. Henry, Joseph Van Camp, John J. López, Wayne Richenbacher, Jeffrey M. Isner, Richard A. Schatz,
This phase I open label, dose-escalating study shows that gene transfer of vascular endothelial growth factor-2 naked deoxyribonucleic acid by direct myocardial injection by way of thoracotomy in patients with Canadian Cardiovascular Society class 3 or 4 angina is feasible and safe. The procedure is well tolerated, with few major adverse cardiac events at 1 year, and without complications directly related to gene expression. In this prospective, nonblinded study, the procedure is associated with ...
Tópico(s): Cardiac and Coronary Surgery Techniques
2003 - Elsevier BV | The American Journal of Cardiology
Jeffrey M. Isner, Victor J. Ferrans, Steven R. Cohen, Bruce G. Witkind, Renu Virmani, John S. Gottdiener, J. Robert Beck, William C. Roberts,
Tópico(s): Cancer Treatment and Pharmacology
1983 - Elsevier BV | The American Journal of Cardiology
Marvin A. Konstam, Nicholas S. Hill, John D. Bonin, Jeffrey M. Isner,
The effect of the cyclooxygenase inhibitors ibuprofen and meclofenamate were studied to assess the role of prostaglandin release in mediating the hemodynamic response to acute pulmonary microembolism in awake rabbits. In Group I (n = 10), a control group receiving only saline infusion, there was no change in pulmonary artery pressure, thermodilution cardiac output, or pulmonary vascular resistance. Group II (n = 12) received sequential intravenous doses of polyacrylamide microspheres averaging 34 μ in ...
Tópico(s): Nitric Oxide and Endothelin Effects
1987 - Informa | Experimental Lung Research
Darryl D. Esakof, Michael Maysky, Douglas W. Losordo, Peter R. Vale, Kishor G. Lathi, John O. Pastore, James F. Symes, Jeffrey M. Isner,
Gene transfer for therapeutic angiogenesis represents a novel treatment for patients with chronic angina refractory to standard medical therapy and not amenable to conventional revascularization. We sought to assess the role of intraoperative multiplane transesophageal echocardiography (MPTEE) in guiding injection of naked DNA encoding vascular endothelial growth factor (VEGF) into the left ventricular (LV) myocardium of patients with refractory angina. After exposing the LV myocardium via a limited ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
1999 - Mary Ann Liebert, Inc. | Human Gene Therapy
Mark W. Wolfe, Gary S. Roubin, Marc J. Schweiger, Jeffrey M. Isner, James J. Ferguson, Adam Cannon, Michael Cleman, Henry S. Cabin, Ferdinand Leya, Raoul Bonan, John Strony, Burt Adelman, John A. Bittl,
Although several studies have established that the complications of percutaneous transluminal coronary angioplasty (PTCA) are related to clinical and angiographic variables such as advanced age and lesion complexity, it is uncertain whether the use of hospital resources after PTCA also depends on the same baseline variables. The purpose of this study was to identify the factors responsible for prolonged hospital stay after PTCA.The study cohort included 591 consecutive patients undergoing conventional ...
Tópico(s): Cardiac Imaging and Diagnostics
1995 - Lippincott Williams & Wilkins | Circulation
Jeffrey M. Isner, Kenneth Rosenfield, Douglas W. Losordo, Shawn C Kelly, Paul Palefski, R.Eugene Langevin, Syed Razvi, John O. Pastore, Bernard D. Kosowsky,
Catheter-based ultrasound (US) transducers may be introduced into the vascular system to record high-resolution images of the vessel wall and lumen. The potential advantages and existing liabilities of percutaneous intravascular US as an adjunct to transluminal vascular recanalization were investigated. A 6.6-F braided, polyethylene catheter enclosing a rotary drive shaft with a single-element, 20-MHz transducer at the distal tip was used in 17 patients undergoing percutaneous transluminal (balloon) ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
1990 - Radiological Society of North America | Radiology
Douglas W. Losordo, John O. Pastore, Deborah Coletta, Donna Kenny, Jeffrey M. Isner,
The objective of this study was to determine the validity of estimation of regurgitant volume by visual assessment of color flow Doppler display. An experimental apparatus was designed that is capable of ejecting precise volumes of echogenic material from one chamber to another under continuous color flow Doppler monitoring. The velocity of flow was altered independently by changing either the size of the orifice through which flow occurred or the ejection rate. In this manner the differential effects ...
Tópico(s): Atrial Fibrillation Management and Outcomes
1993 - Elsevier BV | American Heart Journal
John D. Bonin, Edwin W. Lojeski, Alon Ahron, Jeffrey M. Isner, Richard H. Clarke, Natesa G. Pandian, Roberta Fortin Donaldson, Deeb N. Salem, Marvin A. Konstam, Douglas D. Payne, Richard J. Cleveland,
The feasibility of performing a myotomy/myectomy for hypertrophic cardiomyopathy (HC) by means of laser phototherapy was evaluated experimentally in vitro and in vivo, and the procedure then applied to a patient intraoperatively. In vitro experience revealed that the beam of an argon laser, delivered directly or via an optical fiber, could both cut and vaporize myocardium, producing a myotomy/ myectomy morphologically similar to that produced by the conventional blade technique. In vivo experiments, ...
Tópico(s): Cardiovascular Effects of Exercise
1984 - Elsevier BV | The American Journal of Cardiology
John Elliott, Lisa G. Berdan, David R. Holmes, Jeffrey M. Isner, Spencer B. King, Gordon Keeler, Marianne Kearney, Robert M. Califf, Eric J. Topol,
Background Directional atherectomy is a frequently used percutaneous revascularization strategy, but its long-term outcomes have not previously been compared with those of balloon angioplasty in a prospective trial. Methods and Results The 1012 patients enrolled in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT I) were followed for at least 1 year after randomization. Analyses of predetermined end points were performed, including a detailed analysis of the 14 patients who died. ...
Tópico(s): Peripheral Artery Disease Management
1995 - Lippincott Williams & Wilkins | Circulation
John A. Bittl, Thomas J. Ryan, John F. Keaney, James E. Tcheng, Stephen G. Ellis, Jeffrey M. Isner, Timothy A. Sanborn,
The aim of this study was to analyze the risk of vessel perforation during excimer laser angioplasty.Vessel perforation is a serious complication of angioplasty.A total of 764 patients had 858 stenoses treated with excimer laser angioplasty. Laser catheters had a diameter of 1.4, 1.7 or 2 mm. Laser energy was delivered in pulses of 135 ns, at a frequency of 25 s-1 and at a fluence of 30 to 60 mJ/mm2. Follow-up angiography was requested for all patients who did not require emergency bypass surgery. ...
Tópico(s): Cardiac Imaging and Diagnostics
1993 - Elsevier BV | Journal of the American College of Cardiology