Firas Chamas, Mark D. Underwood, Victoria Arango, Lidia Serova, Suham Kassir, John Mann, Esther L. Sabban,
Stress triggers adaptive and maladaptive changes in the central nervous system, including activation of the hypothalamic-pituitary-adrenal axis, and can trigger mood disorders and posttraumatic stress disorder. We examined the effect of immobilization stress (IMO) on gene expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, and the role of cortisol in that response.Regular and adrenalectomized Sprague-Dawley rats were exposed to various repetitions of IMO. ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2004 - Elsevier BV | Biological Psychiatry
Vinod Kumar, Victoria Arango, Shan Xie, Suham Kassir, J. John Mann, Thomas B. Cooper, Basalingappa L. Hungund,
Background Alcoholism is often comorbid with mood disorders and suicide. We recently reported an upregulation of CB1 receptor-mediated signaling in the dorsolateral prefrontal cortex (DLPFC) of subjects with major depression who died by suicide. In the present study, we sought to determine whether the changes in depressed suicides would also be present in alcoholic suicides and whether the endocannabinoid (EC) system plays a role in suicide in alcoholism. Methods The density of CB1 receptor and its ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2005 - Elsevier BV | Biological Psychiatry
Mark D. Underwood, Mihran J. Bakalian, Teresa Escobar, Suham Kassir, J. John Mann, Victoria Arango,
Suicide and major depression are prevalent in individuals reporting early-life adversity. Prefrontal cortex volume is reduced by stress acutely and progressively, and changes in neuron and glia density are reported in depressed suicide decedents. We previously found reduced neurotrophic factor brain-derived neurotrophic factor in suicide decedents and with early-life adversity, and we sought to determine whether cortex thickness or neuron or glia density in the dorsolateral prefrontal and anterior ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2019 - University of Oxford | The International Journal of Neuropsychopharmacology
Louisa J. Steinberg, Mark D. Underwood, Mihran J. Bakalian, Suham Kassir, J. John Mann, Victoria Arango,
Serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. The temporal lobe receives a high density of serotonergic afferent projections, and responses in the primary auditory cortex to sound are modulated by serotonergic tone. However, the associations between changes in serotonergic tone, disease state and changes in auditory cortical function remain to be clarified.We quantified serotonin 1A (5-HT1A) receptor binding, serotonin 2A (5-HT2A) receptor ...
Tópico(s): Neural dynamics and brain function
2019 - Canadian Medical Association | Journal of Psychiatry and Neuroscience
L. Lee Dupuis, Cathryn Sibbald, Tal Schechter, Marc Ansari, Adam Gassas, Yves Théorêt, Nastya Kassir, Martin Champagne, John Doyle,
We currently calculate area under the busulfan concentration time curve (AUC) using 7 plasma busulfan concentrations (AUC7) drawn after the first of 16 i.v. busulfan doses given as a 2-hour infusion every 6 hours. The aim of this study was to develop and validate limited sampling strategies (LSSs) using 3 or fewer busulfan concentration values with which to reliably calculate AUC in children undergoing hematopoietic stem cell transplant (HSCT). Children in the development group (44) received i.v. busulfan ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2008 - Elsevier BV | Biology of Blood and Marrow Transplantation
Radwan Kassir, Christopher H. Rassekh, John Kinsella, John Segas, Ricardo L. Carrau, Jim Hokanson,
Abstract To assess the role of adjuvant therapy in the treatment of osteogenic sarcoma of the head and neck, treatment and survival information from 173 patients with osteosarcoma of the head and neck was entered into a database. A meta‐analysis of the data was attempted with primary emphasis on the effect of adjuvant therapy on disease outcome. The overall 5‐year survival was 37%. Patients with mandibular and maxillary tumors had similar survival rates; both groups fared significantly better than ...
Tópico(s): Cardiac tumors and thrombi
1997 - Wiley | The Laryngoscope
María A. Oquendo, Stefani A. Russo, Mark D. Underwood, Suham Kassir, Steven P. Ellis, J. John Mann, Victoria Arango,
Background In vivo studies find altered serotonin function associated with aggressive and suicidal behaviors. Postmortem studies also reveal serotonergic alterations in suicide subjects but have not reported on the relationship between aggression and the serotonin system. We measured 5-hydroxytryptamine 2A (5-HT 2A ) receptor binding in prefrontal cortex of suicide and nonsuicide subjects and explored the relationship between 5-HT 2A receptor binding, lifetime aggression, and suicide. Methods The 5-HT 2A receptor ...
Tópico(s): Bipolar Disorder and Treatment
2005 - Elsevier BV | Biological Psychiatry
Jaya Prabhakaran, Mark D. Underwood, J.S. Dileep Kumar, Norman R. Simpson, Suham Kassir, Mihran J. Bakalian, J. John Mann, Victoria Arango,
Radiosynthesis and in vitro evaluation of [18F]-2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-(2-fluoroethoxy)benzyl)ethanamine, ([18F]FECIMBI-36) or ([18F]1), a potential agonist PET imaging agent for 5-HT2A/2C receptors is described. Syntheses of reference standard 1 and the corresponding des-fluoroethyl radiolabeling precursor (2) were achieved with 75% and 65% yields, respectively. In vitro pharmacology assay of FECIMBI-36 by [3H]-ketanserin competition binding assay obtained from NIMH-PDSP showed high affinities ...
Tópico(s): Tryptophan and brain disorders
2015 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
I Dajti, José Ignacio Valenzuela, L Boccalatte, Nicolas A Gemelli, Dantwan Smith, Nagendra N. Dudi‐Venkata, Hidde M. Kroon, Tarik Sammour, Matthew M. Roberts, D Mitchell, K Lah, A Pearce, Dion Morton, Amanda Dawson, A Drane, Claire Sharpin, Ramesh Nataraja, Maurizio Pacilli, Daniel Cox, Vijayaragavan Muralidharan, Georgina Riddiough, Edmund Clarke, Wael Jamel, Kirby R. Qin, Peter Pockney, Daron Cope, N Egoroff, Natalie Lott, Sven Putnis, S De Robles, Zen Yang Ang, Martin Mitteregger, Stefan Uranitsch, Marjorie Stiegler, Gerald Seitinger, Felix Aigner, D B Lumenta, Sebastian P. Nischwitz, Erika Richtig, Mauro Pau, Petra Srekl-Filzmaier, Nicolas Eibinger, Birgit Michelitsch, Melanie Fediuk, A Papinutti, Geoffrey Seidel, Joseph Kahn, Tina Cohnert, Donna A. Messner, F. Ofner, J Presl, Márta Varga, Michael Weitzendorfer, K. Emmanuel, Alf-Dorian Binder, Marc Zimmermann, S Holawe, Emeka Nkenke, Christoph Grimm, M Kranawetter, Ashrarur Rahman Mitul, Nazmul Islam, Syed S. Karim, Niels Komen, Sven Putnis, S De Robles, Emily Ang, Herbert De Praetere, Tim Tollens, G Schols, C. Smets, Laura Haenen, Jorien Quintens, K Van Belle, Gabriëlle H. van Ramshorst, Piet Pattyn, Liesbeth Desender, Thomas Martens, Dirk Van de Putte, Philip Lerut, Aude Grimonprez, Marcus L.F. Janssen, G. De Smul, P. Wallaert, Jef Van den Eynde, Wouter Oosterlinck, Raf Van den Eynde, An Sermon, A. Boeckxstaens, Anne-Laure Cordonnier, Jeroen De Coster, Joris Jaekers, Constantinus Politis, Marc Miserez, Nicolas Duchateau, Charles de Gheldere, Nicolas Flamey, Piet Pattyn, A Christiano, Benedetta Guidi, A L Minussi, Sílvia Castro, Willy Okoba, F H R Maldonado, Paulo Oliveira, Tiago Antônio Baldasso, Luciano Marques dos Santos, Gustavo Mendonça Ataíde Gomes, Igor Lima Buarque, Laércio Pol Fachin, Tainá Santos Bezerra, Aldo Vieira Barros, A Silva, A L S Leite, Daniela Silvestre, C Carvalho Ferro, M S Araujo, L. M. Lopes, P D Damasceno, D H S Araujo, Gustavo Andreazza Laporte, M Salem, Marco Guimarães-Filho, Lucas Souto Nacif, Ronald Luiz Gomes Flumignan, Luís CU Nakano, Danielle Akemi Bergara Kuramoto, A L S Aidar, Mariana Raffo Pereda, R M Correia, Brena Costa Santos, Alzira Alves de Siqueira Carvalho, Jorge Eduardo de Amorim, Henrique Jorge Guedes Neto, Libnah Leal Areias, Álvaro Francisco Lopes de Sousa, Carolina Dutra Queiroz Flumignan, W G Lustre, Doris Hupfeld Moreno, Nathana Prado de Almeida Barros, José Carlos Costa Baptista‐Silva, Leandro Luongo de Matos, L P Kowaski, Marco Aurélio Vamondes Kulcsar, KS Nunes, Marcos F.S. Teixeira, Rafael Leite Nunes, Takeshi Ijichi, N. J. Kim, Ana Beatriz Pontes Marreiro, Bárbara Müller, Joseph Awada, Glauco Baiocchi, Luiz Paulo Kowalski, JG Vartanian, Fabiana B. Makdissi, Samuel Aguiar, Nuno Marques, Genival Barbosa de Carvalho, Tatiana Marques, Emne Ali Abdallah, Charles Edouard Zurstrassen, Jamie Gross, Stênio de Cássio Zéqui, Bruna Tirapelli Gonçalves, Sigrid de Sousa dos Santos, João Pedreira Duprat Neto, Felipe José Fernández Coimbra, Rafael De Cicco, Flávio Roberto Takeda, Ivan Cecconello, Ulysses Ribeiro, A Gatti, R Oliva, C Nardi, Mihail Slavchev, Boyko Atanasov, Nikolay Belev, Angela Dell, David L. Bigam, Khaled Dajani, S Al Riyami, Janet Martin, Davy Cheng, Hua Yang, A Fayad, François Martin Carrier, E. Amzallag, Joannie Desroches, Marie T. Ruel, Natasha Caminsky, Marylise Boutros, J Moon, E. G. C. Wong, Tsafrir Vanounou, Jonathan Pelletier, S Wong, Elie Girsowicz, J Bayne, Daniel I. Obrand, Heather L. Gill, Oren K. Steinmetz, Kenneth MacKenzie, Marie‐Amélie Lukaszewski, Ghader Jamjoum, Philippe Richebé, Olivier Verdonck, S Discepola, Nathalie Godin, M. Idrissi, Vincent Lecluyse, Geneviève Côté, Sebastian Demyttenaere, Richard Garfinkle, Marylise Boutros, A Kouyoumdjian, Marylise Boutros, Sinziana Dumitra, J Moon, E. G. C. Wong, Kosar Khwaja, Lan Luo, Marie‐Amélie Lukaszewski, Heather L. Gill, Gerald J. Berry, Adrienne Liberman, Elie Girsowicz, J Bayne, Daniel I. Obrand, Oren K. Steinmetz, Kenneth MacKenzie, Severin Schmid, Jonathan Spicer, Mehdi Farsi, Jad Abou‐Khalil, Étienne J. Couture, Seyede Momeneh Mohammadi, Hugo Tremblay, Nathalie Gagné, Anne Bergeron, Alexis F. Turgeon, O. Costerousse, David Bellemare, C. Babin, Catherine Blier, M L Wood, Amit Persad, Gary Groot, Hau Pham, Frédérick D’Aragon, Élaine Carbonneau, Maude Bouchard, Marie-Hélène Masse, F Pesant, Jennifer Héroux, Paul J. Karanicolas, Julie Hallet, A Nadler, Avery B. Nathens, M Ko, A Brar, Kelly Mayson, B Kidane, Sadeesh Srinathan, M Escudero, Janette T. Reyes, María Marta Modolo, P Ramirez Nieto, Rodrígo Sepúlveda, A Bolbarán, Andrés Molero‐Chamizo, Isaac Ruiz, Gabriel Reyes, Rafael Salas, Cristóbal Suazo, Rodrigo Muñoz, E Grasset, Martín Inzunza, Nicolás Besser, M J Irarrázaval, Cristián Jarry, Felipe Bellolio, C A Romero Manqui, M Ruiz Esquide, T. Fuentes, José Luis Campos, C. Perez, Payton Cabrera, Raúl Eduardo Pinilla Morales, Óscar Guevara, LJ Jimenez Ramirez, B G Velasquez Cuasquen, Damián Mora, A Bonilla, Sandra Diaz, E Manrique,
To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in surgical patients with SARS-CoV-2. We found that patient rather than operation factors were the best predictors and used these to create the COVIDsurg Mortality Score (https://covidsurgrisk.app). Our data demonstrates that it is safe to restart a wide ...
Oxford University Press
Mark D. Underwood, Mihran J. Bakalian, Virginia L. Johnson, Suham Kassir, Steven P. Ellis, J. John Mann, Victoria Arango,
Glutamate is an excitatory neurotransmitter binding to 3 classes of receptors, including the N-methyl, D-aspartate (NMDA) receptor. NMDA receptor binding is lower in major depression disorder and suicide. NMDA receptor blocking with ketamine can have antidepressant and anti-suicide effects. Early-life adversity (ELA) may cause glutamate-mediated excitotoxicity and is more common with major depression disorder and in suicide decedents. We sought to determine whether NMDA-receptor binding is altered ...
Tópico(s): Tryptophan and brain disorders
2020 - University of Oxford | The International Journal of Neuropsychopharmacology
Mark D. Underwood, Suham Kassir, Mihran J. Bakalian, Hanga Galfalvy, J. John Mann, Victoria Arango,
Although serotonin receptor and cytoarchitectonic alterations are reported in prefrontal cortex (PFC) in suicide and depression, no study has considered binding relative to neuron density. Therefore, we measured neuron density and serotonin transporter (SERT), 5-HT1A and 5-HT2A binding in matched suicides and controls. Suicides and normal controls (n=15 matched pairs) were psychiatrically characterized. Neuron density and binding were determined in dorsal [Brodmann area (BA) 9] and ventral (BA 47) PFC ...
Tópico(s): Memory and Neural Mechanisms
2011 - University of Oxford | The International Journal of Neuropsychopharmacology
Helene Bach, Victoria Arango, Suham Kassir, Téa Tsaava, Andrew J. Dwork, J. John Mann, Mark D. Underwood,
Background Chronic alcohol use depletes brain serotonin (5-hydroxytryptamine [5-HT]), yet we previously found more tryptophan hydroxylase 2 (TPH2), the rate-limiting biosynthetic enzyme for 5-HT, in the dorsal raphe nucleus (DRN) of alcoholics. We sought to determine whether the increase in amount of TPH2 enzyme is associated with more TPH2 mRNA gene expression in the DRN of a new cohort of alcoholics and controls. Methods TPH2 mRNA and protein were measured by in situ hybridization and immunoautoradiography, ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2014 - Wiley | Alcoholism Clinical and Experimental Research
Vinod Kumar, Suham Kassir, Basalingappa L. Hungund, Thomas B. Cooper, J. John Mann, Victoria Arango,
Recent studies in rodents have suggested a role for the central endocannabinoid system in the regulation of mood and alcohol related behaviors. Alcohol use disorder is often associated with suicidal behavior. In the present study, we examined whether abnormalities in the endocannabinoid system in the ventral striatum are associated with alcohol dependence and suicide. The levels of CB1 receptors, receptor-mediated G-protein signaling, and activity and level of the fatty acid amide hydrolase (FAAH) ...
Tópico(s): Forensic Toxicology and Drug Analysis
2009 - Elsevier BV | Journal of Psychiatric Research
Megan L. Fitzgerald, Suham Kassir, Mark D. Underwood, Mihran J. Bakalian, J. John Mann, Victoria Arango,
Inconsistent evidence implicates disruptions of striatal dopaminergic indices in suicide and major depression. To determine whether there are alterations in the striatal dopamine system in suicide, we conducted a quantitative autoradiographic survey of dopamine transporter (DAT; [3H]mazindol), D1 receptor ([3H]SCH23390), and D2 receptor ([3H]sulpiride) binding in the dorsal striatum postmortem from matched suicides and controls. Axis I and axis II psychiatric diagnosis, recent treatment history, and early ...
Tópico(s): Tryptophan and brain disorders
2016 - Springer Nature | Neuropsychopharmacology
J.S. Dileep Kumar, Jaya Prabhakaran, Victoria Arango, Ramin V. Parsey, Mark D. Underwood, Norman R. Simpson, Suham Kassir, Vattoly J. Majo, Ronald L. Van Heertum, J. John Mann,
Synthesis and in vitro evaluation of [O-methyl-(11)C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide ([(11)C]-1), a potential imaging agent for CB(1) receptors using PET is described. 1-(2-Chlorophenyl)-5-(4-hydroxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (5), the precursor for radiolabeling, was synthesized from 4-OTBDPS-propiophenone (2) in five steps with 30% overall yield. The reaction of alcohol 5 with [(11)C]MeOTf at 60 degrees ...
Tópico(s): Neuroscience and Neuropharmacology Research
2004 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
H Bach-Mizrachi, Mark D. Underwood, Suham Kassir, Mihran J. Bakalian, Etienne Sibille, Hadassah Tamir, J. John Mann, Victoria Arango,
Major depressive disorder (MDD) and suicide are associated with deficient serotonergic neurotransmission. Tryptophan hydroxylase (TPH) is the rate-limiting biosynthetic enzyme for serotonin. Previously, we reported elevated levels of TPH protein in the dorsal raphe nucleus (DRN) of depressed suicides and now examine expression of neuronal TPH2 mRNA in a cohort of matched controls and depressed suicides (n = 11 pairs). DRN TPH2 mRNA was measured by densitometric analysis of autoradiograms from in situ ...
Tópico(s): Treatment of Major Depression
2005 - Springer Nature | Neuropsychopharmacology
Basalingappa L. Hungund, Vinod Kumar, Suham Kassir, Balapal S. Basavarajappa, Ratnakumar Yalamanchili, Thomas B. Cooper, J. John Mann, Victoria Arango,
Endogenous and exogenous cannabinoids (CBs) acting through the CB1 receptors have been implicated in the regulation of several behavioral and neuroendocrine functions. Modulation of endocannabinoidergic system by ethanol in mouse brain, and the association of suicide and mood disorders with alcoholism suggest possible involvement of the cannabinoidergic system in the pathophysiology of depression and suicide. Therefore, the present study was undertaken to examine the levels of CB1 receptors and mediated ...
Tópico(s): Neuroscience and Neuropharmacology Research
2004 - Springer Nature | Molecular Psychiatry
Mark D. Underwood, Suham Kassir, Mihran J. Bakalian, Hanga Galfalvy, Andrew J. Dwork, J. John Mann, Victoria Arango,
Serotonin neurotransmitter deficits are reported in suicide, major depressive disorder (MDD) and alcohol use disorder (AUD). To compare pathophysiology in these disorders, we mapped brain serotonin transporter (SERT), 5-HT
Tópico(s): Suicide and Self-Harm Studies
2018 - Springer Nature | Translational Psychiatry
Jaya Prabhakaran, Vattoly J. Majo, Matthew S. Milak, Suham Kassir, Mikael Palner, Lyudmila Savenkova, Mali Pratap, Victoria Arango, J. John Mann, Ramin V. Parsey, J.S. Dileep Kumar,
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C]dimethylamino-3(4-methoxyphenyl)-3H-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-one (1), a potential imaging agent for mGluR1 receptors using PET are described. Synthesis of the corresponding desmethyl precursor 2 was achieved by demethylation of the methoxyphenyl compound 1 in 90% yield. Methylation using [11C]MeOTf in presence of NaOH afforded [11C]1 in 30% yield (EOS) with >99% chemical and radiochemical purities and with a specific activity ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2010 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Gregory M. Sullivan, Ramin V. Parsey, J.S. Dileep Kumar, Victoria Arango, Suham Kassir, Yung-yu Huang, Norman R. Simpson, Ronald L. Van Heertum, J. John Mann,
Overstimulation of the CRF type 1 receptor (CRF1) is implicated in anxiety and depressive disorders. The aim of this study was to investigate the in vivo binding characteristics of [11C]R121920 and [11C]DMP696 in the nonhuman primate for application in positron emission tomography (PET) studies of CRF1. PET imaging with the two novel CRF1 radioligands was performed in baboon. In vitro binding studies for CRF1 were performed in postmortem brain tissue of baboon and human to assess sufficiency of receptor ...
Tópico(s): Neuroscience and Neuropharmacology Research
2007 - Elsevier BV | Nuclear Medicine and Biology
Vattoly J. Majo, Victoria Arango, Norman R. Simpson, Jaya Prabhakaran, Suham Kassir, Mark D. Underwood, Mihran J. Bakalian, Peter Canoll, J. John Mann, J.S. Dileep Kumar,
Radiosynthesis and in vitro evaluation of [(18)F](S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide ([(18)F]BMS-754807 or [(18)F]1) a specific IGF-1R inhibitor was performed. [(18)F]1 demonstrated specific binding in vitro to human cancer tissues. Synthesis of reference standard 1 and corresponding bromo derivative (1a), the precursor for radiolabeling were achieved from 2,4-dichloropyrrolo[2,1-f][1,2,4]triazine (4) in ...
Tópico(s): Metabolism, Diabetes, and Cancer
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Makiko Suehiro, Mark D. Underwood, Victoria Arango, Theodore S. Wang, Suham Kassir, Mihran J. Bakalian, Tami Yatabe, Mali Pratap, Ronald L. Van Heertum, J. John Mann,
LY274601 [R-(+)8-thiomethyl-2-(di-n-propyl-amino)tetralin], a full agonist of the 5-HT1A receptor with high affinity and selectivity, was labeled with 11C and 3H, and its in vivo behavior was studied to evaluate [11C]LY274601 as a PET radiotracer for imaging 5-HT1A receptor sites in living brain. Following intravenous tail injection into mice, [11C]LY274601 showed high blood-brain barrier permeability and accumulated in regions known to have high densities of 5-HT1A receptor sites such as the brain ...
Tópico(s): Neuroscience and Neuropharmacology Research
1998 - Elsevier BV | Life Sciences
Natalia Oleinik, Önder Albayram, Mohamed Faisal Kassir, F. Cansu Atilgan, Chase M. Walton, Eda Karakaya, John Kurtz, Alexander V. Alekseyenko, Habeeb Alsudani, Megan A. Sheridan, Zdzisław M. Szulc, Besim Öğretmen,
Abstract The metabolic consequences of mitophagy alterations due to age‐related stress in healthy aging brains versus neurodegeneration remain unknown. Here, we demonstrate that ceramide synthase 1 (CerS1) is transported to the outer mitochondrial membrane by the p17/PERMIT transporter that recognizes mislocalized mitochondrial ribosomes (mitoribosomes) via 39‐FLRN‐42 residues, inducing ceramide‐mediated mitophagy. P17/PERMIT‐CerS1‐mediated mitophagy attenuated the argininosuccinate/fumarate/malate ...
Tópico(s): Sleep and Wakefulness Research
2023 - Wiley | Aging Cell
M. Hanief Sofi, Linlu Tian, Steven Schutt, Imran Mahmood Khan, Hee-Jin Choi, Yongxia Wu, David Bastian, Taylor Ticer, Mohamed Faisal Kassir, F. Cansu Atilgan, Jisun Kim, Xiaohui Sui, Aleksandra Živković, Shikhar Mehrotra, John P. O’Bryan, Holger Stark, Paul J. Martin, Besim Öğretmen, Xue‐Zhong Yu,
Tópico(s): Hematopoietic Stem Cell Transplantation
2022 - Springer Nature | Leukemia
Mella Adlersberg, Victoria Arango, Shu‐chi Hsiung, J. John Mann, Mark D. Underwood, Kuo‐peing Liu, Suham Kassir, David A. Ruggiero, Hadassah Tamir,
Agonist activation of G protein-coupled receptors induces an increase in the binding of guanosine 5′-(γ-[35S]thio)triphosphate ([35S]GTPγS); this increase in binding has been used as a tool to investigate receptor interaction with the heterotrimer guanine nucleotide-binding regulatory protein (G protein). The present study uses agonist-stimulated [35S]GTPγS binding to characterize serotonin 5-HT2A/2C receptors in rat brain membrane fractions and demonstrate the anatomical localization of the receptors ...
Tópico(s): Ion channel regulation and function
2000 - Wiley | Journal of Neuroscience Research
J. John Mann, Yung-yu Huang, Mark D. Underwood, Suham Kassir, Sara Oppenheim, Thomas M. Kelly, Andrew J. Dwork, Victoria Arango,
Major depression and suicide are associated with fewer serotonin transporter (5-HTT) sites. The 5'-flanking promoter region of the 5-HTT gene has a biallelic insertion/deletion (5-HTTLPR). We assayed prefrontal cortical (PFC) 5-HTT binding in major depression and suicide and examine the relationship to the 5-HTTLPR allele.Postmortem brain samples from 220 individuals were genotyped for the 5-HTTLPR polymorphism. Binding of 5-HTT was assayed by quantitative autoradiography in the PFC of a subset of ...
Tópico(s): Ion channel regulation and function
2000 - American Medical Association | Archives of General Psychiatry
Jaya Prabhakaran, Victoria Arango, Vattoly J. Majo, Norman R. Simpson, Suham Kassir, Mark D. Underwood, Hanish Polavarapu, Jeffrey N. Bruce, Peter Canoll, J. John Mann, J.S. Dileep Kumar,
Synthesis and in vitro evaluation of [(18)F](R)-N-(4-bromo-2-fluorophenyl)-7-((1-(2-fluoroethyl)piperidin-3-yl)methoxy)-6-methoxyquinazolin-4-amine ((R)-[(18)F]FEPAQ or [(18)F]1), a potential imaging agent for the VEGFR2, using phosphor image autoradiography are described. Synthesis of 2, the desfluoroethyl precursor for (R)-FEPAQ was achieved from t-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (3) in five steps and in 50% yield. [(18)F]1 was synthesized by reaction of sodium salt of compound 2 with [(18) ...
Tópico(s): Barrier Structure and Function Studies
2012 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Yaseen M. Arabi, Anthony Gordon, Lennie Derde, Alistair Nichol, Srinivas Murthy, Farah Al Beidh, Djillali Annane, Lolowa Al Swaidan, Abi Beane, Richard Beasley, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte Bradbury, Frank M. Brunkhorst, Meredith Buxton, Adrian Buzgau, Allen C. Cheng, Menno D. de Jong, Michelle A. Detry, Eamon Duffy, Lise J Estcourt, Mark Fitzgerald, Rob Fowler, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas Hills, Christopher M. Horvat, David T. Huang, Andrew J. King, François Lamontagne, Patrick R. Lawler, Roger Lewis, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Salim Malakouti, Daniel F. McAuley, Anna McGlothlin, Shay McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Paul Mouncey, Katrina Orr, Rachael Parke, Rachael Parke, Asad E. Patanwala, Kathy Rowan, Marlene Santos, Christina Saunders, Christopher W. Seymour, Manu Shankar‐Hari, Steven Y. C. Tong, Alexis F. Turgeon, Anne Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Scott Berry, John C. Marshall, Colin McArthur, Derek Angus, Steven A. Webb, Farah Al-Beidh, Derek Angus, Djillali Annane, Yaseen M. Arabi, Abi Beane, Wilma van Bentum-Puijk, Scott Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte Bradbury, Frank Brunkhorst, Meredith Buxton, Allen C. Cheng, Lennie Derde, Lise J Estcourt, Herman Goossens, Anthony Gordon, Cameron Green, Rashan Haniffa, François Lamontagne, Patrick R. Lawler, Edward Litton, John C. Marshall, Colin McArthur, Daniel F. McAuley, Shay McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Paul Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Rachael Parke, Kathy Rowan, Marlene Santos, Christopher W. Seymour, Alexis F. Turgeon, Anne Turner, Frank L. van de Veerdonk, Steve Webb, Ryan Zarychanski, Yaseen M. Arabi, Lewis Campbell, Allen C. Cheng, Lennie Derde, Andrew Forbes, David Gattas, Cameron Green, Stéphane Héritier, Peter Krüger, Edward Litton, Colin McArthur, Shay McGuinness, Alistair Nichol, Rachael Parke, Rachael Parke, Sandra Peake, Jeffrey Presneill, Ian Seppelt, Tony Trapani, Anne Turner, Steve Webb, Paul J. Young, Zahra Bhimani, Brian H. Cuthbertson, Rob Fowler, François Lamontagne, John C. Marshall, Venika Manoharan, Srinivas Murthy, Marlene Santos, Alexis F. Turgeon, Ryan Zarychanski, Diptesh Aryal, Abi Beane, Arjen Dondrop, Cameron Green, Rashan Haniffa, Madiha Hashmi, Issrah Jawad, Deva Jayakumar, John C. Marshall, Colin McArthur, Srinivas Murthy, Timo Tolppa, Vanessa Singh, Steve Webb, Farah Al-Beidh, Derek Angus, Djillali Annane, Wilma van Bentum-Puijk, Scott Berry, Marc J. M. Bonten, Frank Brunkhorst, Maurizio Cecconi, Lennie Derde, Stéphan Ehrmann, Herman Goossens, Anthony Gordon, Colin McArthur, Paul Mouncey, Alistair Nichol, Lorraine Parker, Mathias W. Pletz, Pedro Póvoa, Gernot Rohde, Kathy Rowan, Steve Webb, Brian Alexander, Derek Angus, Kim Basile, Meredith Buxton, Timothy D. Girard, Christopher M. Horvat, David T. Huang, Kelsey Linstrum, Florian Mayr, Bryan J. McVerry, Stephanie K. Montgomery, Christopher W. Seymour, Richard Beasley, Marc J. M. Bonten, Allen C. Cheng, Nick Daneman, Lennie Derde, Robert Fowler, David Gattas, Anthony Gordon, Cameron Green, Peter Krüger, Colin McArthur, Steve McGloughlin, Susan C. Morpeth, Srinivas Murthy, Alistair Nichol, Mathias W. Pletz, David L. Paterson, Gernot Rohde, Steve Webb, Derek Angus, Wilma van Bentum-Puijk, Lennie Derde, Anthony Gordon, Peter Krüger, Edward Litton, John C. Marshall, Colin McArthur, Srinivas Murthy, Alistair Nichol, Balasubramanian Venkatesh, Steve Webb, Derek Angus, Scott Berry, Marc J. M. Bonten, Allen C. Cheng, Lennie Derde, Herman Goossens, Menno D. de Jong, John C. Marshall, Colin McArthur, Srinivas Murthy, Tim Uyeki, Steve Webb, Derek Angus, Yaseen M. Arabi, J. Kenneth Baillie, Richard Beasley, Scott Berry, Marc J. M. Bonten, Allen C. Cheng, Menno D. de Jong, Lennie Derde, Eamon Duffy, Rob Fowler, Herman Goossens, Anthony Gordon, Cameron Green, Thomas Hills, Colin McArthur, Susan C. Morpeth, Srinivas Murthy, Alistair Nichol, Katrina Orr, Rachael Parke, Rachael Parke, Asad E. Patanwala, Kathy Rowan, Steven Y. C. Tong, Tim Uyeki, Frank L. van de Veerdonk, Steve Webb, Derek Angus, Yaseen M. Arabi, J. Kenneth Baillie, Richard Beasley, Scott Berry, Marc J. M. Bonten, Frank Brunkhorst, Allen C. Cheng, Nichola Cooper, Olaf L. Cremer, Menno D. de Jong, Lennie Derde, Eamon Duffy, James Galea, Herman Goossens, Anthony Gordon, Cameron Green, Thomas Hills, Andrew J. King, Helen L. Leavis, John C. Marshall, Florian Mayr, Colin McArthur, Bryan J. McVerry, Susan C. Morpeth, Srinivas Murthy, Mihai G. Netea, Alistair Nichol, Kayode Ogungbenro, Katrina Orr, Rachael Parke, Asad Patawala, Ville Pettilä, Emma Rademaker, Kathy Rowan, Manoj Saxena, Christopher W. Seymour, Steven Tong Wendy Sligl,
To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The primary endpoint was an ordinal scale of organ support-free days. Analyses used a Bayesian cumulative logistic model and expressed treatment effects as an adjusted ...
Springer Science+Business Media
J.S. Dileep Kumar, Ramin V. Parsey, Suham Kassir, Vattoly J. Majo, Matthew S. Milak, Jaya Prabhakaran, Norman R. Simpson, Mark D. Underwood, J. John Mann, Victoria Arango,
[11C]CUMI-101 is the first selective serotonin receptor (5-HT1AR) partial agonist radiotracer for positron emission tomography (PET) tested in vivo in nonhuman primates and humans. We evaluated specific binding of [3H]CUMI-101 by quantitative autoradiography studies in postmortem baboon and human brain sections using the 5-HT1AR antagonist WAY-100635 as a displacer. The regional and laminar distributions of [3H]CUMI-101 binding in baboon and human brain sections matched the known distribution of [3H] ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2013 - Elsevier BV | Brain Research
Produção Nacional
Revisado por pares
Mohammad Kermansaravi, Sonja Chiappetta, Chetan Parmar, Scott A. Shikora, Gerhard Prager, Teresa LaMasters, Jaime Ponce, Lilian Kow, Abdelrahman Nimeri, Shanu N. Kothari, Edo O. Aarts, Syed Imran Abbas, Ahmad Aly, Ali Aminian, Ahmad Bashir, Estuardo Behrens, Helmuth Billy, Miguel Ángel Martín Carbajo, Benjamin Clapp, Jean‐Marc Chevallier, Ricardo V. Cohen, J. Dargent, Bruno Dillemans, Sílvia Leite Faria, Manoel Galvão Neto, Pierre Y. Garneau, Khaled Gawdat, Ashraf Haddad, Mohamad Hayssam ElFawal, Kelvin Higa, Jaques Himpens, Farah Husain, Matthew M. Hutter, Kazunori Kasama, Radwan Kassir, Amir Khan, Mousa Khoursheed, Matthew Kroh, Marina Kurian, Wei‐Jei Lee, Ken Loi, Kamal Mahawar, Corrigan L. McBride, Hazem Al-Momani, John Melissas, Karl Miller, Monali Misra, Mario Musella, C. Joe Northup, Mary O’Kane, Pavlos Papasavas, Mariano Palermo, Richard M. Peterson, Ralph Peterli, Luis Poggi, Janey Pratt, Aayad Alqahtani, Almino Ramos, Karl Peter Rheinwalt, Rui Ribeiro, Ann M. Rogers, Bassem Safadi, Paulina Salminen, Sérgio Santoro, Nathaniel Sann, John D. Scott, Asim Shabbir, Stephanie Sogg, Erik Stenberg, Michel Suter, Antonio Torres, Surendra Ugale, Ramón Vilallonga, Cunchuan Wang, Rudolf A. Weiner, Natán Zundel, Luigi Angrisani, Maurizio De Luca,
Abstract Metabolic and bariatric surgery (MBS) is widely considered the most effective option for treating obesity, a chronic, relapsing, and progressive disease. Recently, the American Society of Metabolic and Bariatric Surgery (ASMBS) and the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) issued new guidelines on the indications for MBS, which have superseded the previous 1991 National Institutes of Health guidelines. The aim of this study is to establish the first ...
Tópico(s): Obesity and Health Practices
2024 - Nature Portfolio | Scientific Reports