Thomas Cooper, John Green, H. Johnson, E. T. Edmistone,
... Report, The Princess Alice, Extraordinary Suicide, Coals, General Totleben, the Well Known Russian General, Fell from His ...
1857 - Gale Group | NCCO BritishPolitics
Jaan A. Pesti, Chien‐Kuang Chen, Lori A. Spangler, Albert J. DelMonte, Serge Benoit, Derek D. Berglund, Jeffrey T. Bien, Paul R. Brodfuehrer, Yeung Chan, Elisabeth Corbett, Carrie Costello, Paul Demena, Robert P. Discordia, Wendel W. Doubleday, Zhinong Gao, Stéphane Gingras, John A. Grosso, Oscar W. Haas, David J. Kacsur, Chiajen Lai, Simon Leung, Melanie M. Miller, Jale Müslehiddinoğlu, Nina Nguyen, Jun Qiu, Martina Olzog, Emily Reiff, D. Thoraval, Michael J. Totleben, Dale Vanyo, Purushotham Vemishetti, John Wasylak, Chenkou Wei,
The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demonstration through plant scale preparations are presented. A controlled means to prepare a Grignard reagent and utilization of Fourier Transform Infrared spectroscopy (FTIR) monitoring to safely conduct the reaction is featured.
Tópico(s): Antifungal resistance and susceptibility
2009 - American Chemical Society | Organic Process Research & Development
J. Siva Prasad, Truc Chi Vu, Michael J. Totleben, Gerard A. Crispino, David J. Kacsur, Shankar Swaminathan, John E. Thornton, A. W. FRITZ, Ambarish K. Singh,
Two well-known methodologies, the Jacobsen asymmetric epoxidation (AE) and the Sharpless asymmetric dihydroxylation (AD) followed by epoxidation, were evaluated for the large-scale preparation of a chiral dihydrobenzofuran epoxide. The AE method was improved by substituting ethanol for dichloromethane for the dissolution of meta-chloroperbenzoic acid (m-CPBA). This change in solvent had a significant impact on scaleability of the AE procedure by preventing crystallization of the m-CPBA during addition ...
Tópico(s): Organic Chemistry Cycloaddition Reactions
2003 - American Chemical Society | Organic Process Research & Development
Shikai Zhao, Michael J. Totleben, Jeremiah P. Freeman, Christopher L. Bacon, Gerard B. Fox, Esther O'Driscoll, Andrew Foley, John F. Kelly, U. Farrell, Ciaran M. Regan, S. A. MIZSAK, Jacob Szmuszkovicz,
Tacrine, one of the drugs available for Alzheimer's disease based on the cholinergic approach, suffers from considerable toxicity. Many analogues of tacrine have been prepared which retain the pharmacologically rich aminopyridine or aminoquinoline motifs. The current research was undertaken to produce an acetylcholinesterase inhibitor by employing 11-aminobenzoquinolizidines (4) and 10-aminobenzoindolizidines (5) as templates. Thus, we aimed to achieve three goals relative to tacrine: eliminate the ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
1999 - Elsevier BV | Bioorganic & Medicinal Chemistry