Ana Rita Goncalves Cabecinhas, Tim Roloff, Madlen Stange, Claire Bertelli, Michael Huber, Alban Ramette, Chaoran Chen, Sarah Nadeau, Yannick Gerth, Sabine Yerly, Onya Opota, Trestan Pillonel, Tobias Schuster, César Metzger, Jonas Sieber, Michael Bel, Nadia Wohlwend, Christian R. Baumann, Michel C. Koch, Pascal Bittel, Karoline Leuzinger, Myrta Brunner, Franziska Suter‐Riniker, Livia Berlinger, Kirstine K. Søgaard, Christiane Beckmann, Christoph Noppen, Maurice Redondo, Ingrid Steffen, Helena M. B. Seth-Smith, Alfredo Mari, Reto Lienhard, Martin Risch, Oliver Nolte, Isabella Eckerle, Gladys Martinetti Lucchini, Emma B. Hodcroft, Richard A. Neher, Tanja Stadler, Hans H. Hirsch, Stephen L. Leib, Lorenz Risch, Laurent Kaiser, Alexandra Trkola, Gilbert Greub, Adrian Egli,
The rapid spread of the SARS-CoV-2 lineages B.1.1.7 (N501Y.V1) throughout the UK, B.1.351 (N501Y.V2) in South Africa, and P.1 (B.1.1.28.1; N501Y.V3) in Brazil has led to the definition of variants of concern (VoCs) and recommendations for lineage specific surveillance. In Switzerland, during the last weeks of December 2020, we established a nationwide screening protocol across multiple laboratories, focusing first on epidemiological and microbiological definitions. In January 2021, we validated and ...
Tópico(s): Animal Virus Infections Studies
2021 - Multidisciplinary Digital Publishing Institute | Microorganisms
A. D. Vlasov, Brian D. Metzger, Jonas Lippuner, Luke F. Roberts, Todd A. Thompson,
We explore heavy element nucleosynthesis in neutrino-driven winds from rapidly-rotating, strongly magnetized proto-neutron stars for which the magnetic dipole is aligned with the rotation axis, and the field is assumed to be a static force-free configuration. We process the proto-magnetar wind trajectories calculated by Vlasov et al 2014 through the r-process nuclear reaction network SkyNet using contemporary models for the evolution of the wind electron fraction during the proto-neutron star cooling ...
Tópico(s): Pulsars and Gravitational Waves Research
2017 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Produção Nacional
Revisado por pares
Valéria C. Sandrim, Marcelo F. Montenegro, Ana C. Palei, Ingrid F. Metzger, Jonas T. Sertório, Ricardo de Carvalho Cavalli, José E. Tanus‐Santos,
Contrasting with increased nitric oxide (NO) formation during healthy pregnancy, reduced NO bioavailability plays a role in preeclampsia. However, no study has examined whether increased NO consumption by enhanced circulating levels of cell-free hemoglobin plays a role in preeclampsia. We studied 82 pregnant women (38 healthy pregnant and 44 with preeclampsia). To assess NO bioavailability, we measured plasma and whole blood nitrite concentrations using an ozone-based chemiluminescence assay. Plasma ...
Tópico(s): Birth, Development, and Health
2010 - Elsevier BV | Free Radical Biology and Medicine
Produção Nacional
Revisado por pares
Ingrid F. Metzger, Jonas T. Sertório, José E. Tanus‐Santos,
Tópico(s): Renin-Angiotensin System Studies
2007 - Elsevier BV | Free Radical Biology and Medicine
Produção Nacional
Revisado por pares
Ingrid F. Metzger, Jonas T. Sertório, José E. Tanus‐Santos,
Abstract Aim: Nitric oxide (NO) is an endogenous mediator of many physiological processes, many of which are mediated by cyclic guanosine 3′,5′‐monophosphate (cGMP). Much effort has been made to validate clinical markers of NO production or bioavailability. While the measurement of plasma nitrate, nitrite, and cGMP concentrations have been suggested to reflect endogenous production of NO, there is no study showing whether there is correlation between these three markers. In the present study, we investigate ...
Tópico(s): Neuroscience of respiration and sleep
2006 - Wiley | Acta Physiologica
Susan Athey, Guido W. Imbens, Jonas Metzger, Evan Munro,
When researchers develop new econometric methods it is common practice to compare the performance of the new methods to those of existing methods in Monte Carlo studies. The credibility of such Monte Carlo studies is often limited because of the discretion the researcher has in choosing the Monte Carlo designs reported. To improve the credibility we propose using a class of generative models that has recently been developed in the machine learning literature, termed Generative Adversarial Networks ( ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2021 - Elsevier BV | Journal of Econometrics
Nina Loretz, Christoph Becker, Seraina Hochstrasser, Kerstin Metzger, Katharina Beck, Jonas Mueller, Sebastian Groß, Alessia Vincent, Simon A. Amacher, Raoul Sutter, Kai Tisljar, Philipp Schüetz, Luca Bernasconi, Peter Neyer, Hans Pargger, Stephan Märsch, Sabina Hunziker,
Activation of the kynurenine pathway (KP) has been shown to predict outcome in cardiac arrest (CA) patients. We validated these findings in a Swiss cohort. We measured admission tryptophan and kynurenine levels in 270 consecutive CA patients (38 in-hospital CA) and investigated associations with in-hospital mortality and neurological outcome at hospital discharge. 120 of 270 (44%) patients died in the hospital. Compared to survivors, non-survivors showed higher median initial kynurenine levels (5.28 ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2021 - Elsevier BV | Journal of Critical Care
Produção Nacional
Revisado por pares
Sabrina Nagassaki, Jonas T. Sertório, Ingrid F. Metzger, Andreza Fabro de, João Batista Teixeira da Rocha, José E. Tanus‐Santos,
Statins inhibit cholesterol synthesis and produce pleiotropic, cholesterol-independent effects including endothelial NO synthase (eNOS) stimulation and increased expression. However, a functional polymorphism in the promoter of the eNOS gene (T-786C) reduces its activity and could modulate the response to statins. Here, we examined whether this polymorphism modulates the effects of atorvastatin on the plasma levels of markers of NO formation and oxidative stress. We genotyped 200 healthy subjects ...
Tópico(s): Renin-Angiotensin System Studies
2006 - Elsevier BV | Free Radical Biology and Medicine
Tobias Stein, Jasmin Metzger, Jonas Scherer, Fabian Isensee, Tobias Norajitra, Jens Kleesiek, Klaus Maier‐Hein, Marco Nolden,
Tópico(s): Medical Imaging Techniques and Applications
2019 - Springer Nature | Informatik aktuell
Abstract. This article discusses current transformations from nomadism to labor migration and tourism in the local economy in the Moroccan mountain village Ameskar Fogani. Using the concepts of field, habitus and symbolic capital of Bourdieu's "theory of practice", changes in economic practices are analyzed in relation to changes of (symbolic) meanings and perceptual categories. This perspective sheds light on the close interrelation of economic and cultural aspects of social change.
Tópico(s): Religious Tourism and Spaces
2014 - Copernicus Publications | Geographica Helvetica
Michał Ślęzak, Christian Göritz, Aurore Niemiec, Jonas Frisén, Pierre Chambon, Daniel Metzger, Frank W. Pfrieger,
Abstract Astrocytes are thought to exert diverse functions in the brain, but it has been difficult to prove this in vivo because of a scarcity of tools to manipulate these cells. Here, we report the generation of new transgenic mouse lines that allow for conditional gene ablation in astrocytes using the tamoxifen‐ (TAM‐) inducible CreER T2 /loxP system and bacterial artificial chromosome (BAC)‐based transgenesis. In adult transgenic mice, where CreER T2 expression is driven by the promoter of the sodium‐ ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2007 - Wiley | Glia
César Metzger, Reto Lienhard, Helena M. B. Seth-Smith, Tim Roloff, Fanny Wegner, Jonas Sieber, Michael Bel, Gilbert Greub, Adrian Egli,
The new SARS-CoV-2 Omicron variant (B.1.1.529) has been recently declared a Variant of Concern due to a series of important mutations in the viral spike protein and especially in the receptor-binding domain. While investigations into the spread of this new variant are ongoing, the first cases have been detected in Switzerland. Important questions have been raised: (1) Will the PCR assays commonly used to detect SARS-CoV-2 still work for the Omicron variant? (2) Can specific PCR features, e.g. S-gene ...
Tópico(s): Animal Virus Infections Studies
2021 - EMH Swiss Medical Publishers Ltd. | Schweizerische medizinische Wochenschrift
Alexander Zubovich, Sabrina Metzger, Tilo Schöne, Jonas Kley, O. I. Mosienko, Cornelia Zech, Bolot Moldobekov, A. Shsarshebaev,
Abstract The constant increase of geodetic instrumentation over the past decades enables us to not only detect ever smaller tectonic signals but also to monitor their evolution in time and space. We present spatial and temporal slip variations observed on a fault affected by a large, intermediate‐field earthquake: the 2015 M w 7.2 Sarez, Central Pamir, earthquake ruptured the sinistral, NE‐trending Sarez‐Karakul fault system. 120–170 km North of the main rupture, the thin‐skinned, E‐trending Pamir ...
Tópico(s): Geology and Paleoclimatology Research
2022 - Wiley | Tectonics
B Schönemeier, Jochen Metzger, Julie Klein, Holger Husi, Birgit Bremer, Nina Armbrecht, Mohammed Dakna, Joost P. Schanstra, Jonas Rosendahl, Johannes Wiegand, Mark D. Jäger, William Mullen, Benjamin Breuil, Ruben R. Plentz, Ralf Lichtinghagen, Korbinian Brand, Florian Kühnel, Harald Mischak, Michael P. Manns, Tim O. Lankisch,
Objectives Differentiation of pancreatic cancer (PCA) from chronic pancreatitis (CP) is challenging. We searched for peptide markers in urine to develop a diagnostic peptide marker model. Methods Capillary electrophoresis–mass spectrometry was used to search for peptides in urine of patients with PCA (n = 39) or CP (n = 41). Statistical different peptides were included in a peptide multimarker model. Peptide markers were sequence identified and validated by immunoassay and immunohistochemistry (IHC). Results ...
Tópico(s): Advanced Proteomics Techniques and Applications
2016 - Lippincott Williams & Wilkins | Pancreas
Jonas Scherer, Marco Nolden, Jens Kleesiek, Jasmin Metzger, Klaus Kades, Verena Schneider, Michael Bach, Oliver Sedlaczek, Andreas Bucher, Thomas J. Vogl, Frank Grünwald, Jens‐Peter Kühn, Ralf‐Thorsten Hoffmann, Jörg Kotzerke, O Bethge, Lars Schimmöller, Gerald Antoch, Hans‐Wilhelm Müller, Andreas Daul, Konstantin Nikolaou, Christian la Fougère, Wolfgang G. Kunz, Michael Ingrisch, Balthasar Schachtner, Jens Ricke, Peter Bartenstein, Felix Nensa, Alexander Radbruch, Lale Umutlu, Michael Forsting, Robert Seifert, Ken Herrmann, Philipp Mayer, Hans‐Ulrich Kauczor, Tobias Penzkofer, Bernd Hamm, Winfried Brenner, Roman Kloeckner, Christoph Düber, Mathias Schreckenberger, Rickmer Braren, Georgios Kaissis, Marcus R. Makowski, Matthias Eiber, Andrei Gafita, Rupert Trager, Wolfgang Weber, Jakob Neubauer, Marco Reisert, Michael Bock, Fabian Bamberg, Jürgen Hennig, Philipp T. Meyer, Juri Ruf, Uwe Haberkorn, Stefan O. Schoenberg, Tristan Anselm Kuder, Peter Neher, Ralf Floca, Heinz‐Peter Schlemmer, Klaus Maier‐Hein,
PURPOSE Image analysis is one of the most promising applications of artificial intelligence (AI) in health care, potentially improving prediction, diagnosis, and treatment of diseases. Although scientific advances in this area critically depend on the accessibility of large-volume and high-quality data, sharing data between institutions faces various ethical and legal constraints as well as organizational and technical obstacles. METHODS The Joint Imaging Platform (JIP) of the German Cancer Consortium ( ...
Tópico(s): Artificial Intelligence in Healthcare and Education
2020 - Lippincott Williams & Wilkins | JCO Clinical Cancer Informatics
C. J. Horowitz, Almudena Arcones, Benoît Côté, I. Dillmann, W. Nazarewicz, Ian U. Roederer, H. Schatz, A. Aprahamian, D. Atanasov, Andreas Bauswein, Timothy C. Beers, Judith M. Bliss, M. Brodeur, J A Clark, Anna Frebel, François Foucart, C. J. Hansen, Oliver Just, A. Kankainen, G. C. McLaughlin, James Kelly, S. N. Liddick, David M. Lee, Jonas Lippuner, D. Martin, J. Mendoza-Temis, Brian D. Metzger, Matthew Mumpower, G. Perdikakis, J. Pereira, Brian W. O’Shea, R. Reifarth, A. M. Rogers, Daniel M. Siegel, A. Spyrou, Rebecca Surman, Xindi Tang, Tomohiro Uesaka, M. Wang,
This is an exciting time for the study of r-process nucleosynthesis. Recently, a neutron star merger GW170817 was observed in extraordinary detail with gravitational waves and electromagnetic radiation from radio to γ rays. The very red color of the associated kilonova suggests that neutron star mergers are an important r-process site. Astrophysical simulations of neutron star mergers and core collapse supernovae are making rapid progress. Detection of both electron neutrinos and antineutrinos from ...
Tópico(s): Pulsars and Gravitational Waves Research
2019 - IOP Publishing | Journal of Physics G Nuclear and Particle Physics
Elfriede Bollschweiler, Jonas Apitzsch, Rainer Obliers, Armin Koerfer, Stefan Mönig, Ralf Metzger, Arnulf H. Hölscher,
In Brief Objective: The term "informed consent" explains the process by which a patient, before treatment, is provided comprehensive and impartial information regarding a planned operative procedure so that he/she understands the implications of the procedure before consenting. The goal of the current study was to investigate whether standard methods of consenting can be improved using a multimedia-based information program (MM-IP). Patients and Methods: In a prospective multicenter study, 80 patients ...
Tópico(s): Palliative Care and End-of-Life Issues
2008 - Lippincott Williams & Wilkins | Annals of Surgery
Frederik Zietzschmann, Stefan Dittmar, Lydia Splettstößer, Jonas Hunsicker, Daniel Dittmann, Felix Meinel, Annette Rößler, Steffen Metzger, Martin Jekel, Aki Sebastian Ruhl,
Powdered activated carbon (PAC) for organic micro-pollutant (OMP) removal can be applied effectively on wastewater treatment plant (WWTP) effluents by using re-circulation schemes, accumulating the PAC in the system. This technique is complex because several factors are unknown: (i) the PAC concentration in the system, (ii) specific and average contact times of PAC particles, and (iii) PAC particle loadings with target compounds/competing water constituents. Thus, performance projections (e.g. in the lab) ...
Tópico(s): Carbon Dioxide Capture Technologies
2018 - Elsevier BV | Chemosphere
Jonas F. Hummel, Philipp Metzger, Roland Sonntag, Dennis Borrero-Wolff, Cynthia Obodozie, Holger Weber,
... and differentiation of immune cell populations. Citation Format: Jonas F. Hummel, Philipp Metzger, Roland Sonntag, Dennis Borrero-Wolff, Cynthia Obodozie, Holger ...
Tópico(s): Advanced Biosensing Techniques and Applications
2024 - American Association for Cancer Research | Cancer Research
S. Baird, D. Berlin, J. Boillot, J. Bosser, M. Brouet, J. Buttkus, F. Caspers, V. Chohan, D. Dekkers, Tommy Eriksson, R. Garoby, R. Giannini, O. Gröbner, Jonas Gruber, J.Y. Hémery, H. Koziol, R. Maccaferri, S. Maury, C. Metzger, K D Metzmacher, D. Möhl, H. Mulder, M. Paoluzzi, F. Pedersen, J.P. Riunaud, Ch. Serre, D. Simon, G. Tranquille, J.W.N. Tuyn, B. Williams,
In view of a possible future programme of physics with low-energy antiprotons, a simplified scheme for the provision of antiprotons at 100 MeV/c has been studied. It uses the present target area and the modified Antiproton Collector (AC) in its present location. In this report the modifications and the operation are discussed.
Tópico(s): Radiation Therapy and Dosimetry
1997 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
Derek B.J. Bone, Jaroslawna Meister, Jonas R. Knudsen, Diptadip Dattaroy, Amanda Cohen, Regina J. Lee, Huiyan Lü, Daniel Metzger, Thomas E. Jensen, Jürgen Wess,
Skeletal muscle (SKM) insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Because G-protein–coupled receptors (GPCRs) represent excellent drug targets, we hypothesized that activation of specific functional classes of SKM GPCRs might lead to improved glucose homeostasis in type 2 diabetes. At present, little is known about the in vivo metabolic roles of the various distinct GPCR signaling pathways operative in SKM. In this study, we tested the hypothesis that selective ...
Tópico(s): Diabetes Treatment and Management
2019 - American Diabetes Association | Diabetes
Jonas Lippuner, Rodrigo Fernández, Luke F. Roberts, François Foucart, Daniel Kasen, Brian D. Metzger, Christian D. Ott,
We investigate the nucleosynthesis of heavy elements in the winds ejected by accretion disks formed in neutron star mergers. We compute the element formation in disk outflows from hypermassive neutron star (HMNS) remnants of variable lifetime, including the effect of angular momentum transport in the disk evolution. We employ long-term axisymmetric hydrodynamic disk simulations to model the ejecta, and compute r-process nucleosynthesis with tracer particles using a nuclear reaction network containing $\ ...
Tópico(s): Astrophysical Phenomena and Observations
2017 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Matthias Sukopp, Nina Schwab, Jonas Schwer, J Frey, J Metzger, Anita Ignatius, Mario Perl, Firooz Salami, Daniel Vogele, Thomas Kappe, Andreas Seitz,
Abstract Purpose The aim of this study was to investigate the influence of medial meniscus posterior root avulsion (MMPRA) before and after surgical treatment on the biomechanics of the knee joint, including suture repair forces during daily and crutch‐assisted gait movements. Methods MMPRA were investigated in eight human cadaver knee joint specimens by a dynamic knee joint simulator with daily (normal gait, gait with additional rotational movement, standing up, sitting down) and rehabilitation‐associated ...
Tópico(s): Sports injuries and prevention
2024 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Daniel Fenner, Andreas Christen, Sue Grimmond, Fred Meier, William H. Morrison, Matthias Zeeman, Janet F. Barlow, Joern Birkmann, Lewis Blunn, Nektarios Chrysoulakis, Matthew Clements, Russell Glazer, Denise Hertwig, Simone Kotthaus, K. König, Dana Looschelders, Zina Mitraka, Dimitris Poursanidis, Dimitris Tsirantonakis, Benjamin Bechtel, Kit Benjamin, Frank Beyrich, Ferdinand Briegel, Gregor Feigel, Carlotta Gertsen, Nimra Iqbal, Jonas Kittner, Humphrey Lean, Yiqing Liu, Zhiwen Luo, Megan McGrory, Swen Metzger, Matthew Paskin, Marvin Ravan, Thomas Ruhtz, Bethany Saunders, Dieter Scherer, Stefán Thor Smith, Megan Stretton, Katja Trachte, Melania Van Hove,
Abstract For next-generation weather and climate numerical models to resolve cities, both higher spatial resolution and subgrid parameterizations of urban canopy–atmosphere processes are required. The key is to better understand intraurban variability and urban–rural differences in atmospheric boundary layer (ABL) dynamics. This includes upwind–downwind effects due to cities’ influences on the atmosphere beyond their boundaries. To address these aspects, a network of >25 ground-based remote sensing ...
Tópico(s): Climate Change and Health Impacts
2024 - American Meteorological Society | Bulletin of the American Meteorological Society
B Schönemeier, J Metzger, Jonas Rosendahl, Rodrigo Della Méa Plentz, Johannes Wiegand, Harald Mischak, MP Manns, TO Lankisch,
Hintergrund: Pankreaskarzinome stellen weltweit die fünft häufigste Todesursache aller Krebserkrankungen dar. Da verlässlicher Marker für die Früherkennung fehlen, wird die Diagnose häufig zu spät für eine kurative Therapie gestellt.
Tópico(s): Advanced Biosensing Techniques and Applications
2013 - Thieme Medical Publishers (Germany) | Zeitschrift für Gastroenterologie
Bastian Schoenemeier, Jochen Metzger, Jonas Rosendahl, Ruben R. Plentz, Johannes Wiegand, Harald Mischak, Michael P. Manns, Tim O. Lankisch,
was 619 pg/ml compared to 384 pg/ml in the CP unlikely group (p= 0.001).We observed a linear association between the number of EUS criteria and PGE2 levels: for each additional EUS criteria, mean PGE2 levels increased by 61pg/ml.This association was significant in both univariate ( β = 0.34, p= 0.03) and multivariate analysis (β = 0.35, p= 0.03) after adjusting for age, gender, and nonsteroidal anti-inflammatory drugs use.In contrast, bicarbonate levels decreased by 4.5 mEq/L with each additional EUS criteria ( ...
Tópico(s): Vitamin D Research Studies
2013 - Elsevier BV | Gastroenterology
Ralf Metzger, Jonas Andermahr, Klaus E. Rehm,
Tópico(s): Bone fractures and treatments
2002 - Springer Science+Business Media | European Journal of Trauma
Julian M.M. Rogasch, Hans V. Jochens, Giulia Metzger, Christoph Wetz, Jonas Kaufmann, Christian Furth, Holger Amthauer, Imke Schatka,
Purpose The latest iteration of GPT4 (generative pretrained transformer) is a large multimodal model that can integrate both text and image input, but its performance with medical images has not been systematically evaluated. We studied whether ChatGPT with GPT-4V(ision) can recognize images from common nuclear medicine examinations and interpret them. Patients and Methods Fifteen representative images (scintigraphy, 11; PET, 4) were submitted to ChatGPT with GPT-4V(ision), both in its Default and “ ...
Tópico(s): COVID-19 diagnosis using AI
2024 - Lippincott Williams & Wilkins | Clinical Nuclear Medicine
Robert K. Hills, Steffi Oesterreich, Otto Metzger, David J. Dabbs, Hongchao Pan, Jeremy Braybrooke, Richard Gray, Richárd Pető, Rosie Bradley, Ewan Straiton, Richard Berry, Daniel Rea, David Cameron, Jack Cuzick, Meredith M. Regan, Mitch Dowsett, Ivana Šestak, Jonas Bergh, Sandra M. Swain, John M.S. Bartlett,
... Citation Format: Robert K Hills, Steffi Oesterreich, Otto Metzger, David Dabbs, Hongchao Pan, Jeremy Braybrooke, Richard Gray, Richard Peto, Rosie Bradley, Ewan Straiton, Richard Berry, Daniel Rea, David Cameron, Jack Cuzick, Meredith Regan, Mitch Dowsett, Ivana Sestak, Jonas Bergh, Sandra M Swain, John Bartlett, Early Breast ...
Tópico(s): Advanced Breast Cancer Therapies
2022 - American Association for Cancer Research | Cancer Research
Michael Meir, Jonas Salm, Christina Fey, Matthias Schweinlin, Cathérine Kollmann, Felix Kannapin, Christoph‐Thomas Germer, Jens Waschke, Christopher A. Beck, Natalie Burkard, Marco Metzger, Nicolas Schlegel,
Abstract Background The mechanisms underlying loss of intestinal epithelial barrier [IEB] function in Crohn’s disease [CD] are poorly understood. We tested whether human enteroids generated from isolated intestinal crypts of CD patients serve as an appropriate in vitro model to analyse changes of IEB proteins observed in patients’ specimens. Methods Gut samples from CD patients and healthy individuals who underwent surgery were collected. Enteroids were generated from intestinal crypts and analyses ...
Tópico(s): Gut microbiota and health
2020 - Oxford University Press | Journal of Crohn s and Colitis