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Artigo Brasil Produção Nacional Revisado por pares

Marcela Lopes, C. De Sena, Bruno Silva, Cristina de Fátima de Oliveira Brum Augusto de Souza, Jonas Pereira Ramos, Geovanni Dantas Cassali, Elaine M. Souza–Fagundes, Ricardo José Alves, Mônica Cristina Oliveira, Renata Barbosa de Oliveira,

Twenty-seven nitrated and non-nitrated compounds have been synthesized and tested for their growth inhibitory activity on three human cancer cells lines. Fourteen compounds were able to inhibit more than 50% of the growth of at least one of the cancer cell lines and five compounds exhibited high antiproliferative activity on human cancer cell lines (IC50 < 8.5 μM). The cytotoxicity of the compounds on Vero cell line was established in vitro to evaluate the selectivity. All active compounds have a good ...

Tópico(s): Synthesis and biological activity

2015 - Bentham Science Publishers | Anti-Cancer Agents in Medicinal Chemistry

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Betânia Barros Cota, Luiza Guimarães Tunes, Daniela Nabak Bueno Maia, Jonas Pereira Ramos, Djalma Menezes de Oliveira, Markus Kohlhoff, Tânia Maria de Almeida Alves, Elaine M. Souza–Fagundes, Fernanda Fraga Campos, Carlos Leomar Zani,

BACKGROUND In a screen of extracts from plants and fungi to detect antileishmanial activity, we found that the ethyl acetate extract of the fungus Nectria pseudotrichia, isolated from the tree Caesalpinia echinata (Brazilwood), is a promising source of bioactive compounds. OBJECTIVES The aims of this study were to isolate and determine the chemical structures of the compounds responsible for the antileishmanial activity of the organic extract from N. pseudotrichia. METHODS Compounds were isolated ...

Tópico(s): Plant biochemistry and biosynthesis

2017 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Saulo Fehelberg Pinto Braga, Nayara Cristina Fonseca, Jonas Pereira Ramos, Elaine M. Souza–Fagundes, Renata Barbosa de Oliveira,

ABSTRACT The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero cells) cell lines, and to evaluate the pro-apoptotic potential of the most active compounds. Materials and Methods: The thiosemicarbazones were obtained by reacting an aromatic aldehyde with thiosemicarbazide (yield 71-96%), which were subjected to a cyclization with α-bromoacetophenone to yield the required ...

Tópico(s): Metal complexes synthesis and properties

2016 - UNIVERSIDADE DE SÃO PAULO | Brazilian Journal of Pharmaceutical Sciences

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Fernanda Fraga Campos, Jonas Pereira Ramos, Djalma Menezes de Oliveira, Tânia Maria de Almeida Alves, Elaine M. Souza–Fagundes, Carlos Leomar Zani, Fábio Coelho Sampaio, Attílio Converti, Betania Barros Cota,

The bioassay-guided fractionation of the ethyl acetate extract of the fungus Cochliobolus sp. highlighted leishmanicidal activity and allowed for anhydrocochlioquinone A (ANDC-A) isolation. MS, 1D and 2D NMR spectra of this compound were in agreement with those published in the literature. ANDC-A exhibited leishmanicidal activity with EC 50 value of 22.4 microgram/mL (44 mu M) and, when submitted to the microdilution assay against Gram-ositive and Gram-negative bacteria, showed a minimal inhibitory ...

Tópico(s): Research on Leishmaniasis Studies

2017 - Springer Science+Business Media | Journal of Biosciences

Artigo Brasil Produção Nacional Revisado por pares

Gabrieli L. Parrilha, K.S.O. Ferraz, Josane A. Lessa, Kely Navakoski de Oliveira, Bernardo L. Rodrigues, Jonas Pereira Ramos, Elaine M. Souza–Fagundes, Ingo Ott, Heloísa Beraldo,

Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone (H2Ac4oClPh) were assayed for their cytotoxicity against MCF-7 breast adenocarcinoma and HT-29 colon carcinoma cells. The thiosemicarbazone and most of the complexes were highly cytotoxic. H2Ac4oClPh and its gallium(III) and tin(IV) complexes did not show any inhibitory activity against thioredoxin reductase (TrxR) and glutathione reductase (GR). The palladium(II), platinum(II) and bismuth(III) complexes inhibited TrxR at ...

Tópico(s): Redox biology and oxidative stress

2014 - Elsevier BV | European Journal of Medicinal Chemistry

Artigo Brasil Produção Nacional

Gabriella A.R. Oliveira, Jonas T. Guimarães, Gustavo Luís de Paiva Anciens Ramos, Erick A. Esmerino, Tatiana Colombo Pimentel, Roberto P.C. Neto, Maria Inês Bruno Tavares, Louise A. Sobral, Felipe Souto, Mônica Q. Freitas, Leonardo Emanuel O. Costa, Adriano G. Cruz,

This study aimed to evaluate the effect of short-time heat-treatment (HTST, 90 °C/20 s) and thermosonication (TS) at temperatures of 70, 80, and 90 °C (TS70, TS80, and TS90) on the quality parameters of orange juice whey drinks. Formulations with different orange juice/reconstituted whey proportions were subjected to sensory analysis, and the ideal formulation was established through survival analysis (31% whey, 69% orange juice). This formulation showed approval of 75% of the consumers, which is considered ...

Tópico(s): Microencapsulation and Drying Processes

2021 - Elsevier BV | Innovative Food Science & Emerging Technologies

Artigo Brasil Produção Nacional Revisado por pares

Cleudiomar Inácio Lino, Igor Gonçalves de Souza, Beatriz M. Borelli, Thelma Tirone Silvério Matos, Iasmin Natália Santos Teixeira, Jonas Pereira Ramos, Elaine M. Souza–Fagundes, Philipe Oliveira Fernandes, Vinícius Gonçalves Maltarollo, Susana Johann, Renata Barbosa de Oliveira,

In the search for new antifungal agents, a novel series of fifteen hydrazine-thiazole derivatives was synthesized and assayed in vitro against six clinically important Candida and Cryptococcus species and Paracoccidioides brasiliensis. Eight compounds showed promising antifungal activity with minimum inhibitory concentration (MIC) values ranging from 0.45 to 31.2 μM, some of them being equally or more active than the drug fluconazole and amphotericin B. Active compounds were additionally tested for ...

Tópico(s): Nail Diseases and Treatments

2018 - Elsevier BV | European Journal of Medicinal Chemistry

Artigo Brasil Produção Nacional Revisado por pares

Saulo Fernandes de Andrade, Bárbara Gonçalves de Oliveira, Larissa C. Pereira, Jonas Pereira Ramos, Angélica Rocha Joaquim, Martin Steppe, Elaine M. Souza–Fagundes, Ricardo José Alves,

In the present work we describe the synthesis and antiproliferative evaluation of a focused library of 30 novel oxazolidines designed by modification of N-substituent, by ring variation, by alkyl variation or by extension of the structure. It was noted that carbamate and N,O-aminal groups were essential for activity. In general, replacement of the phenyl ring with pyridinyl was not tolerated. However, the introduction of a second phenyl ring with an appropriate spacer at the 3- or 4-position of ...

Tópico(s): Synthesis and Catalytic Reactions

2017 - Elsevier BV | European Journal of Medicinal Chemistry

Artigo Brasil Produção Nacional Revisado por pares

Jonas T. Guimarães, Hugo Scudino, Gustavo Luís de Paiva Anciens Ramos, Gabriella A.R. Oliveira, Larissa P. Margalho, Leonardo EO Costa, Mônica Q. Freitas, Maria Carmela K.H. Duarte, Anderson S. Sant’Ana, Adriano G. Cruz,

Emerging technologies are being constantly improved, giving rise to new processes capable of promoting greater nutritional preservation and improved technological characteristics, in addition to the benefits related to energy efficiency. Ultrasound treatment has stood out among the non-thermal technologies, due to several benefits related to microstructural changes and microbial inactivation. The study of this technology is particularly important in dairy products, which represent one of the most ...

Tópico(s): Radiation Effects and Dosimetry

2021 - Elsevier BV | Current Opinion in Food Science

Artigo Brasil Produção Nacional Revisado por pares

Saulo Fernandes de Andrade, Cláudia Salviano Teixeira, Jonas Pereira Ramos, Marcela Silva Lopes, Rodrigo Maia de Pádua, Mônica Cristina Oliveira, Elaine M. Souza–Fagundes, Ricardo José Alves,

Rigidification of the structure of 2,3,4-trisubstituted oxazolidines enhances the activity against LNCaP cells without affecting normal cell proliferation.

Tópico(s): Organic Chemistry Cycloaddition Reactions

2014 - Royal Society of Chemistry | MedChemComm

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Jonas Nascimento de Sousa, Aylla Beatriz Melo de Oliveira, Andressa Kelly Ferreira, Eduardo Ramos de Almeida Silva, Leide Maria Soares de Sousa, Melissa Carvalho França Rocha, José Pinto de, Siqueira Júnior, Glenn W. Kaatz, Jackson Roberto Guedes da Silva Almeida, João Sammy Nery de Souza, Humberto Medeiros Barreto,

Microdilution assays were performed in order to evaluate the antimicrobial activity of the ethanoic extract from the leaves of Bauhinia forficate (EEBF) against different microorganisms. The extract did not present inner antimicrobial activities against the tested strains. However, EEBF was able to modulate the norfloxacin-resistance against Staphylococcus aureus SA1199-B that overproduce the NorA efflux pump, once sub-inhibitory concentrations of EEBF reduced the minimal inhibitory concentratio ...

Tópico(s): Antimicrobial Peptides and Activities

2019 - Taylor & Francis | Natural Product Research

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Logan Kistler, S. Yoshi Maezumi, Jonas Gregório de Souza, Natalia A. S. Przelomska, Flaviane Malaquias Costa, Oliver Smith, Hope Loiselle, Jazmín Ramos‐Madrigal, Nathan Wales, Eduardo Rivail Ribeiro, Ryan R. Morrison, Claudia Grimaldo, André Prous, Bernardo Arriaza, M. Thomas P. Gilbert, Fábio de Oliveira Freitas, Robin G. Allaby,

Domesticated maize evolved from wild teosinte under human influences in Mexico beginning around 9000 years before the present (yr B.P.), traversed Central America by ~7500 yr B.P., and spread into South America by ~6500 yr B.P. Landrace and archaeological maize genomes from South America suggest that the ancestral population to South American maize was brought out of the domestication center in Mexico and became isolated from the wild teosinte gene pool before traits of domesticated maize were fixed. ...

Tópico(s): Agriculture, Land Use, Rural Development

2018 - American Association for the Advancement of Science | Science

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lígia Eleonor Prezzi, Sarah Hwa In Lee, Valéria M.R. Nunes, Carlos Humberto Corassin, Tatiana Colombo Pimentel, Ramon S. Rocha, Gustavo Luís de Paiva Anciens Ramos, Jonas T. Guimarães, Celso F. Balthazar, Maria Carmela K.H. Duarte, Mônica Q. Freitas, Erick A. Esmerino, Márcia C. Silva, Adriano G. Cruz, Carlos Augusto Fernandes de Oliveira,

This study aimed to evaluate the effect of Lactobacillus rhamnosus GG on growth of Staphylococcus aureus and Listeria monocytogenes, inoculated alone or in combination on surface of Minas Frescal cheeses, during storage for 21 days at 7 °C. Survival percentages of each individual bacterial species after exposure to in vitro simulated gastrointestinal conditions (SGC) were also determined. The addition of L. rhamnosus did not affect (P > 0.05) pH, moisture, fat, protein and texture profile of Minas Frescal ...

Tópico(s): Listeria monocytogenes in Food Safety

2020 - Elsevier BV | Food Microbiology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Fernando Henrique Ramos Silva, Júlio César Pieczarka, Adauto Lima Cardoso, Patrícia Corrêa da Silva, Jonas Alves de Oliveira, Cleusa Yoshiko Nagamachi,

Cytogenetic studies were carried out on samples of Parapteronotus hasemani, Sternarchogiton preto and Sternarchorhamphus muelleri (Apteronotidae, Gymnotiformes) from the Amazon basin. The first two species exhibited both a 2n = 52 karyotype, but differed in their karyotypic formulae, distribution of constitutive heterochromatin, and chromosomal location of the NOR. The third species, Sternarchorhamphus muelleri, was found to have a 2n = 32 karyotype. In all three species the DAPI and chromomycin A3 staining ...

Tópico(s): Genomics and Phylogenetic Studies

2014 - Brazilian Society of Genetics | Genetics and Molecular Biology

Artigo Brasil Produção Nacional Revisado por pares

Milana Drumond Ramos Santana, Brian Kliszczewicz, Franciele Marques Vanderlei, Larissa Raylane Lucas Monteiro, Eli Carlos Martiniano, Yasmim M. de Moraes, Luana Bezerra Mangueira, Guilherme Correia Alcântara, José Ramon A. da Silva, Cicero Jonas R. Benjamim, Fernando Rocha Oliveira, Vítor Engrácia Valenti,

Graded exercises tests are performed in adult populations; nonetheless, the use of this type of assessment is greatly understudied in overweight and obese adolescents.To investigate heart rate autonomic responses to submaximal aerobic exercise in obese and overweight adolescents.We recruited 40 adolescents divided into two groups: (1) overweight group comprising 10 boys and 10 girls between Z-score +1 and +2 and (2) obese group comprising 10 boys and 10 girls above Z-score >+2. Heart rate variability ...

Tópico(s): Non-Invasive Vital Sign Monitoring

2019 - Cambridge University Press | Cardiology in the Young

Artigo Acesso aberto Brasil Produção Nacional

Dheymi Wilma Ramos Silva, Jonas Davi Nogueira Sena, Maria Helena dos Santos Moraes, E’lide Karine Pereira da Silva, Rafael Carvalho de Maria, Aliny de Oliveira Pedrosa, Anderson Araújo Corrêa, Gizelia Araújo Cunha Porto, Jairina Nunes Chaves, Leyla Gerlane De Oliveira Adriano,

Objetivo: Avaliar o conhecimento dos profissionais de enfermagem sobre parada cardiorrespiratória e ressuscitação cardiopulmonar em uma Unidade de Pronto Atendimento. Métodos: Estudo transversal, de natureza descritivo-exploratória com uma abordagem quantitativa, contou com a participação de 62 profissionais da equipe de enfermagem atuante na Unidade de Pronto Atendimento. A coleta de dados foi realizada através de questionário contendo 18 questões e analisados e realizado dados estatísticos. Resultados: ...

Tópico(s): Nursing Diagnosis and Documentation

2020 - Revista Eletronica Acervo Saude | Revista Eletrônica Acervo Saúde

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Daniella Campos Oliveira, Leonardo Alexandre Barros Bezerra, Romário Jonas de Oliveira, Vitocley de Moraes, Juliana Angeiras Batista da Silva, João de Freitas Filho, Juliano Carlo Rufino Freitas, Clécio S. Ramos,

TEACHING.This paper proposes the development of a simple experiment with easily accessible and low cost materials, enabling its practice with or without laboratory infrastructure, with feasibility for computational theoretical study.On the other hand, the objective of the work is to develop a chemical experiment that demonstrates that the chromophore curcumin (natural indicator) is responsible for indicating the acidity or basicity of a given solution.The experiment has different applicability, being ...

Tópico(s): Chemistry Education and Research

2020 - Brazilian Chemical Society | Química Nova

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Renato Pereira de Freitas, Miguel Andrade de Oliveira, Matheus B. de Oliveira, André Rocha Pimenta, Valter S. Felix, Marcelo O. Pereira, Elicardo Alves de Souza Gonçalves, João V. L. Grechi, Fabrício Lopes e Silva, Cristiano Carvalho, Jonas Gabriel Ramos da Silva Ataliba, Leandro de Oliveira Pereira, Lucas Gabriel dos Santos Muniz, Robson B. dos Santos, Vitor da S. Vital,

This work presents the development of a macro X-ray fluorescence (MA-XRF) scanner system for in situ analysis of paintings. The instrument was developed to operate using continuous acquisitions, where the module with the X-ray tube and detector moves at a constant speed, dynamically collecting spectra for each pixel of the artwork. Another possible configuration for the instrument is static acquisitions, where the module with the X-ray tube and detector remains stationary to acquire spectra for each ...

Tópico(s): Building materials and conservation

2024 - Multidisciplinary Digital Publishing Institute | Quantum Beam Science

Artigo Brasil Produção Nacional Revisado por pares

Luís Felipe Barbosa Marques, Jonas Frank Reis, Ana Beatriz Ramos Moreira Abrahão, Luís Rogério de Oliveira Hein, Edson Cocchieri Botelho, Michelle Leali Costa,

This work aims to characterize the influence of hygrothermal conditioning on the mechanical and thermal behavior as well as the fractographic aspects of the interface of poly(ether imide) and glass fiber composite joints welded by electrical resistance using 400 mesh of AISI 304 stainless steel. The composites were mechanically characterized by Lap Shear Strength (LSS) and End Notched Flexure (ENF) testing to investigate maximum shear stress and energy from mode II interlaminar fracture toughness. ...

Tópico(s): Natural Fiber Reinforced Composites

2021 - SAGE Publishing | Journal of Composite Materials

Artigo Brasil Produção Nacional Revisado por pares

João Antônio Bonatto‐Costa, Matheus Aires Melo, Jéssica Deisiane Scherer, Jonas Maximo Cândia, Matheus Ramos, Deivis de Campos, Lino Pinto de Oliveira,

Introdution Playful activities contribute a lot in the learning process of children, and using this through pedagogic games can potentiate the exploring and the construction of knowledge, because allows children to identificate, group and combine information. Knowing this, one of the ways to promote the teaching of anatomy in basic education is through the use of educational games, therefore, making possible the improvement of the student's teaching‐learning process, in the school enviroment. Objetive ...

Tópico(s): Health Education and Validation

2018 - Wiley | The FASEB Journal

Artigo Acesso aberto Brasil Produção Nacional

Marianna Barriviera Prada, José Airton Jorge Alves, Wagner Rodrigues Martins, Evandro Francisco Faulin, Julliana Maria Pinheiro de Sousa, Lilian Carolina Rodrigues da Batista, Raiane Camargos de Carvalho, Angélica Ramos de Oliveira, Bruno Rodrigo Miranda Barbosa, Caroline Jonas Rezaghi Ricomini Nunes, Caroline Peres Sumida Ciocca, Mariana De Melo Lopes, Poliana Amaral de Lima, Renato Valduga, Josevan Cerqueira Leal, João Paulo Chieregato Matheus, Patrícia Azevedo Garcia, Osmair Gomes de Macedo,

Objetivos: verificar o perfil epidemiológico e a prevalência dos traumatismos de membros inferiores de pacientes atendidos por fisioterapeutas em um hospital público do Distrito Federal, demonstrando essa prevalência quanto à região anatômica, o tipo e o mecanismo de lesão e realizar uma análise da função muscular dos membros inferiores de dados de uma avaliação inicial. Método: Trata-se de um estudo descritivo transversal baseado na análise dos dados de fichas de avaliação realizadas durante o ...

Tópico(s): Physical Education and Gymnastics

2022 - | Saúde e Desenvolvimento Humano

Artigo Brasil Produção Nacional Revisado por pares

Jose Maria Barua Godoy, Robson Almir de Oliveira, Gustavo Aguayo, E Martinez Rodriguez, Alfredo Javier Mezger Szostak, Jhonatan Andrade dos Santos, André Pagani Tochetto, Manuel Leonardo Sosa Ríos, Paulo Henrique Galassi, Jonas Pesente, Rodrigo A. Ramos,

This paper presents the ECCANDE project, one of the first Special Protection Schemes (SPS) conceived to rely on the structure of a Wide-Area Monitoring, Protection, and Control System (WAMPACS) and currently operating in a real, large-sized power system. This project was developed and implemented to enable the interconnection between the Argentinean and Paraguayan bulk power transmission systems, which involves and directly affects two of the largest hydropower plants in the world (the Itaipu and Yacyreta ...

Tópico(s): Power Systems Fault Detection

2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Delivery

Artigo Acesso aberto Brasil Produção Nacional

Luiza V. B. de Oliveira, Rodrigo A. Ramos, Daniela A. G. Ferreira, Jonas Pesente,

This work proposes a new didactic approach to the problem of angular stability to large perturbations of an Electrical Power System (SEP) for undergraduate education.There are two main innovative contributions that differentiate the proposed approach from others commonly employed for the same purpose: a) the construction of the area of attraction of the post-fault system, which allows the student to establish a visual and intuitive connection of the physical problem of SEP with concepts of nonlinear ...

Tópico(s): Transportation Safety and Impact Analysis

2020 - | Anais do ... Simpósio Brasileiro de Sistemas Elétricos

Artigo Brasil Produção Nacional Revisado por pares

Camila Aline Romano, Jonas Souza Dourado, R. Ramos-Filho, Renata Cabral, Adelair Helena dos Santos, Jerônimo Raimundo de Oliveira Neto, Luíz Carlos da Cunha, José Realino de Paula,

Tópico(s): Phytochemistry and Bioactive Compounds

2023 - Springer Science+Business Media | Chemistry of Natural Compounds

Artigo Brasil Produção Nacional

Romário Jonas de Oliveira, Bruna Martins Guimarães, Rayane de oliveira Silva, Luis Eduardo Gomes de Holanda, Clécio S. Ramos, Juliano Carlo Rufino Freitas, João R. de Freitas Filho,

Os carboidratos sao as biomoleculas mais abundantes que desempenham papeis fundamentais em muitos processos biologicos. Na quimica dos carboidratos, o S -glicosideo e uma molecula orgânica na qual o acucar e ligado a outro grupo funcional por meio de uma ligacao glicosidica. Nos ultimos anos, houve um avanco na sintese e aplicacoes de S -glicosideos. Apesar de sua quimica desafiadora, os S -glicosideos desempenham papel fundamental no desenvolvimento da quimica de moleculas biologicamente ativas. Nesta ...

Tópico(s): Enzyme Catalysis and Immobilization

2021 - Brazilian Society of Chemistry | Revista Virtual de Química

Artigo Acesso aberto Brasil Produção Nacional

Romário Jonas de Oliveira, Bruna Martins Guimarães, Rayane de Oliveira Silva, Luiz Eduardo Gomes de Holanda, Clécio Souza Ramos Juliano Carlo Rufino Freita, João R. de Freitas Filho,

Carbohydrates are the most abundant biomolecules that play crucial roles in many biological processes.In carbohydrate chemistry, the S-glycoside is an organic molecule in which sugar is bound to another functional group via a glycosidic bond.In the last few years, considerable progress has been made in the synthesis and applications of S-glycosides.Despite their challenging chemistry, S-glycosides play a pivotal role the development of the development of chemistry of biologically active molecules. ...

Tópico(s): Carbohydrate Chemistry and Synthesis

2020 - Brazilian Society of Chemistry | Revista Virtual de Química

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

VITÓRIA SIMPLÍCIO OLIVEIRA, Rafael Resende Lucas, TAYENNE PRADO CARVALHO, Luís Felipe Barbosa Marques, Jonas Frank Reis, Ana Beatriz Ramos Moreira Abrahão, Edson Cocchieri Botelho,

The technology for joining thermoplastics through welding offers numerous advantages over mechanical joining. Currently, the joining of composite parts with weight reduction and cost savings is being developed to improve aircraft performance. This paper proposes the use of oxygen-acetylene as a process for bonding composite materials. Oxyacetylene welding is a simple and economical method that can be suitable for polymeric materials. The advantage of applying this technique is a more accessible ...

Tópico(s): Synthesis and properties of polymers

2021 - American Welding Society | Welding Journal