Kosuke Tsukamoto, D.R. Mani, Jianru Shi, Songwen Zhang, Darrow E. Haagensen, Fumiyuki Otsuka, Jian Guan, Jonathan D. Smith, Wei Weng, Ronglih Liao, Frank D. Kolodgie, Renu Virmani, Monty Krieger,
Significance Coronary artery disease (CAD) is a major cause of death and disability. Genetically modified SR-BI/apoE double KO (dKO) mice spontaneously exhibit many features of human CAD, including hypercholesterolemia, clogged arteries, myocardial infarction (MI) (or heart attack), heart failure, and premature death. We identified many changes in gene expression in dKO hearts [e.g., increases in apolipoprotein D (apoD)] during CAD development and compared them to those occurring after surgically induced ...
Tópico(s): Cardiac Fibrosis and Remodeling
2013 - National Academy of Sciences | Proceedings of the National Academy of Sciences
David G. Anderson, Mark Haagensen, Aline Ferreira‐Correia, Ronald Pierson, Jonathan Carr, Amanda Krause, Russell L. Margolis,
Huntington's Disease-Like 2 (HDL2), caused by a CTG/CAG expansion in JPH3 on chromosome 16q24, is the most common Huntington's Disease (HD) phenocopy in populations with African ancestry. Qualitatively, brain MRIs of HDL2 patients have been indistinguishable from HD. To determine brain regions most affected in HDL2 a cross-sectional study using MRI brain volumetry was undertaken to compare the brains of nine HDL2, 11 HD and nine age matched control participants. Participants were ascertained from ...
Tópico(s): Mitochondrial Function and Pathology
2019 - Elsevier BV | NeuroImage Clinical
Emma J. Haagensen, Huw D. Thomas, Clare Mudd, Elpida Tsonou, Ceri M. Wiggins, Ross J. Maxwell, Jonathan D. Moore, David R. Newell,
Studies to identify predictive biomarkers can be carried out in isogenic cancer cell lines, which enable interrogation of the effect of a specific mutation. We assessed the effects of four drugs, the PI3K–mammalian target of rapamycin inhibitor dactolisib, the PI3K inhibitor pictrelisib, and the MEK (MAPK/ERK Kinase) inhibitors PD 0325901 and selumetinib, in isogenic DLD1 parental, KRAS+/−, KRASG13D/−, PIK3CA+/− and PIK3CAE545K/− colorectal carcinoma cell lines. Importantly, we found substantial ...
Tópico(s): Cancer Genomics and Diagnostics
2016 - Elsevier BV | European Journal of Cancer
Samson Chengetanai, Jonathan Tenley, Mads F. Bertelsen, Therese Hård, Adhil Bhagwandin, Mark Haagensen, Cheuk Y. Tang, Victoria X. Wang, Bridget Wicinski, Patrick R. Hof, Paul R. Manger, Muhammad A. Spocter,
Abstract The African wild dog is endemic to sub‐Saharan Africa and belongs to the family Canidae which includes domestic dogs and their closest relatives (i.e., wolves, coyotes, jackals, dingoes, and foxes). The African wild dog is known for its highly social behavior, co‐ordinated pack predation, and striking vocal repertoire, but little is known about its brain and whether it differs in any significant way from that of other canids. We employed gross anatomical observation, magnetic resonance imaging, ...
Tópico(s): Comparative Animal Anatomy Studies
2020 - Wiley | The Journal of Comparative Neurology
Adam Li, Chester Huynh, Zachary Fitzgerald, Iahn Cajigas, Damian Brusko, Jonathan Jagid, Angel Claudio, Andrés M. Kanner, Jennifer L. Hopp, Stephanie Chen, Jennifer Haagensen, Emily L. Johnson, William S. Anderson, Nathan E. Crone, Sara K. Inati, Kareem A. Zaghloul, Juan Bulacio, Jorge González-Martínez, Sridevi V. Sarma,
Over 15 million patients with epilepsy worldwide do not respond to drugs. Successful surgical treatment requires complete removal or disconnection of the seizure onset zone (SOZ), brain region(s) where seizures originate. Unfortunately, surgical success rates vary between 30 and 70% because no clinically validated biological marker of the SOZ exists. We develop and retrospectively validate a new electroencephalogram (EEG) marker—neural fragility—in a retrospective analysis of 91 patients by using ...
Tópico(s): Neuroscience and Neuropharmacology Research
2021 - Nature Portfolio | Nature Neuroscience
... Harper & Row; 1974:5, 80, 85. Google Scholar14. Haagensen CD. Diseases of the Breast. Philadelphia: WB Saunders; ... Arch Surg. 1996; 131:301-8. Google Scholar40. Haagensen CD, Lane N, Lattes R, Bodian C. Lobular ... S. Cody, Phillip I. Lerner, David J. Rothman, Jonathan H. Sadowsky, Freya R. Schnabel, and Steven Shea ...
Tópico(s): Colorectal Cancer Screening and Detection
1998 - American College of Physicians | Annals of Internal Medicine
David G. Anderson, Mark Haagensen, Aline Ferreira‐Correia, Ronald Pierson, Jonathan Carr, Amanda Krause, Russell L. Margolis,
Background Huntington's Disease-Like 2 (HDL2) is one of the most common Huntington's Disease (HD) phenocopies. Clinical similarities between these genetically different diseases are remarkable and the MRIs between them have been indistinguishable. Objective To compare MRIs between HDL2 and HD against unaffected controls using semiautomated volumetric analysis and morphometry. Methods Participants with a mixed or African ancestry were enrolled from an area with the world's highest frequency of HDL2. All MRIs ...
Tópico(s): Genetic Neurodegenerative Diseases
2018 - Akadémiai Kiadó | Imaging
Louise Lloyd, Susan Jones, Goran Jovanović, Prasad Gyaneshwar, Matthew D. Rolfe, Arthur R. Thompson, Jay C. D. Hinton, Martin Buck,
... Lambert P. Faure P. Kzreminski M. Balestrino D. Haagensen J.A. Molin S. Prensier G. Arbeille B. ... into pTE103 aprThis workpBAD18-cmVector cmrA gift from Jonathan BeckwithpLL8pspG (XbaI-HindIII) cloned into the mcs of ...
Tópico(s): Escherichia coli research studies
2004 - Elsevier BV | Journal of Biological Chemistry
Adam Li, Chester Huynh, Zachary Fitzgerald, Iahn Cajigas, Damian Brusko, Jonathan Jagid, Angel Claudio, Andrés M. Kanner, Jennifer L. Hopp, Stephanie Chen, Jennifer Haagensen, Emily L. Johnson, William S. Anderson, Nathan E. Crone, Sara K. Inati, Kareem A. Zaghloul, Juan Bulacio, Jorge González-Martínez, Sridevi V. Sarma,
Tópico(s): Advanced MRI Techniques and Applications
2022 - Nature Portfolio | Nature Neuroscience
... of Medicine in Early Modern Tibet, rev., 148.Haagensen, Erling; Niels C. Lind (Letter to the Editor), ... Territories of Science and Religion, rev., 613.Harwood, Jonathan, rev. of Derry, Masterminding Nature, 650.Haster, Frank; ...
Tópico(s): High Altitude and Hypoxia
2016 - University of Chicago Press | Isis
... which he hopes will be published soon.Erling Haagensen is an independent Danish author and researcher, specializing ... Animal Language (Chicago, 2007) and, as coeditor with Jonathan Hodge, The Cambridge Companion to Darwin (Cambridge, 2009). ...
2016 - University of Chicago Press | Isis