Amadeu Gavaldà, Israel Ramos, Carla Carcasona, Elena Calama, Raquel Otal, J.L. Montero, Sònia Sentellas, Mónica Aparici, Dolors Vilella, Joan Albertí, Jörge Beleta, Montserrat Miralpeix,
This study characterised the in vitro and in vivo profiles of two novel long-acting muscarinic antagonists, aclidinium bromide and glycopyrronium bromide, using tiotropium bromide and ipratropium bromide as comparators. All four antagonists had high affinity for the five muscarinic receptor sub-types (M1-M5); aclidinium had comparable affinity to tiotropium but higher affinity than glycopyrronium and ipratropium for all receptors. Glycopyrronium dissociated faster from recombinant M3 receptors than ...
Tópico(s): Respiratory and Cough-Related Research
2014 - Elsevier BV | Pulmonary Pharmacology & Therapeutics
Joseph A. Christie‐Oleza, Balbina Nogales, Celia Martín‐Cardona, Mariana P. Lanfranconi, Sebastián Albertí, Jorge Lalucat, Rafael Bosch,
Tópico(s): Vibrio bacteria research studies
2008 - Springer Science+Business Media | International Microbiology
... Dario, Ortega, Whitman, T.S. Eliot, Czeslaw Milosz, Alberti, Lorca, Jorge Cuillen, Rilke, Milton, Beckett, Stefan George, and the ...
Tópico(s): Translation Studies and Practices
1993 - Association of College and Research Libraries | Choice Reviews Online
Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D’Amico, Francesca Buonocunto, Crocefissa Lanzilotti, Gloria Alberti, Jorge Navarro,
ABSTRACT Objective To assess a simple technology solution to support basic communication and leisure in people with neurological disorders, extensive motor impairment, and absence of speech. Design The design was a non-concurrent multiple baseline across participants. Methods The study included eight participants and assessed a technology setup including a Samsung Galaxy Tab S2 LTE tablet and a Samsung Galaxy A3 smartphone. The smartphone, automated via MacroDroid, presented the participant with ...
Tópico(s): Autism Spectrum Disorder Research
2020 - Taylor & Francis | Brain Injury
Wangyang Xu, Ming-min Gu, Lianhua Sun, Wenting Guo, Houbao Zhu, Jianfang Ma, Wentao Yuan, Ying Kuang, JI Baojun, Xiaolin Wu, Yan Chen, Hongxin Zhang, Futing Sun, Wei Huang, Lei Huang, Shengdi Chen, Zhugang Wang,
... Scopus (144) Google Scholar, 4Banchs I. Casasnovas C. Albertí A. De Jorge L. Povedano M. Montero J. Martínez-Matos J. ...
Tópico(s): Neurological diseases and metabolism
2012 - Elsevier BV | The American Journal of Human Genetics
Isabel Banchs, Carlos Casasnovas, Antonia Albertí, Laura Jorge, Mónica Povedano, Jordi Montero, Juan Antonio Martı́nez-Matos, Vı́ctor Volpini,
Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy (HMSN) is a genetically heterogeneous group of conditions that affect the peripheral nervous system. The disease is characterized by degeneration or abnormal development of peripheral nerves and exhibits a range of patterns of genetic transmission. In the majority of cases, CMT first appears in infancy, and its manifestations include clumsiness of gait, predominantly distal muscular atrophy of the limbs, and deformity of ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2009 - Hindawi Publishing Corporation | BioMed Research International
Daymara Mercerón‐Martínez, William Almaguer‐Melian, Esteban Alberti‐Amador, Jorge A. Bergado,
The relationships between affective and cognitive processes are an important issue of present neuroscience. The amygdala, the hippocampus and the prefrontal cortex appear as main players in these mechanisms. We have shown that post-training electrical stimulation of the basolateral amygdala (BLA) speeds the acquisition of a motor skill, and produces a recovery in behavioral performance related to spatial memory in fimbria-fornix (FF) lesioned animals. BLA electrical stimulation rises bdnf RNA expression, ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2018 - Elsevier BV | Brain Research Bulletin
Carlos Casasnovas, Isabel Banchs, Laura Jorge, Maria Alberti, Yolanda Martínez–Campo, Mònica Povedano, Jordi Montero, Vı́ctor Volpini,
Abstract Introduction: In this study we examined a family with electrophysiological findings of hereditary neuropathy with liability to pressure palsies (HNPP) and a mild clinical presentation. Methods: Four members of a family were referred for diagnosis of HNPP. Electrophysiological studies included motor and sensory nerve conduction studies in the upper and lower extremities. Investigations of microsatellites, using polymorphic repeat markers flanking the gene, and multiplex ligation‐dependent ...
Tópico(s): Neurological diseases and metabolism
2011 - Wiley | Muscle & Nerve
Cristina Campos, Jara Laso, Jorge Cristóbal, Jaume Albertí, Alba Bala, Margalida Fullana, Pere Fullana–i–Palmer, María Margallo, Rubén Aldaco,
From an economic point of view, the tourism sector is one of the most important in the world with religious tourism, such as pilgrimages, being a growth area. Tourism activities also make a significant contribution to CO2 emissions (roughly 8% of the world's carbon emissions). In this framework, the main objective of this research is to develop an integrated sustainable model by assessing the impact of pilgrimages to the Camino Lebaniego (Lebaniego Way) in the Cantabrian region, which is one of the ...
Tópico(s): Municipal Solid Waste Management
2022 - Elsevier BV | Journal of Cleaner Production
Rocío García-Carrión, Jorge Aguiar, Esteban Alberti, K. Cuétara, Nancy Pavón,
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2004 - Elsevier BV | Biochemical and Biophysical Research Communications
Juan Alonso León-Abarca, Arianna Portmann-Baracco, Mayte Bryce‐Alberti, Carlos Ruiz-Sánchez, Roberto A. Accinelli, Jorge Soliz, Gustavo F. Gonzáles,
Aims The objective of this study is to analyze how the impact of Diabetes Mellitus [DM] in patients with COVID-19 varies according to altitudinal gradient. Methods We obtained 1,280,806 records from adult patients with COVID-19 and DM to analyze the probability of COVID-19, development of COVID-19 pneumonia, hospitalization, intubation, admission to the Intensive Care Unit [ICU] and case-fatality rates [CFR]. Variables were controlled by age, sex and altitude of residence to calculate adjusted prevalence ...
Tópico(s): COVID-19 and Mental Health
2021 - Public Library of Science | PLoS ONE
María Prat, Dolors Fernández, María Antonia Buil, M. Crespo, Gaspar Casals, Manuel Ferrer, Laia Tort, Jordi Castro, Juan Manuel Monleón, Amadeu Gavaldà, Montserrat Miralpeix, Israel Ramos, Teresa Domènech, Dolors Vilella, Francisca Antón, José María Huerta, Sònia Espinosa, Manuel López, Sònia Sentellas, Marisa González, Joan Albertí, Vı́ctor Segarra, Á. de Pablo Cárdenas, Jörge Beleta, Hamish Ryder,
The objective of this work was to discover a novel, long-acting muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD), with a potentially improved risk−benefit profile compared with current antimuscarinic agents. A series of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters were synthesized and evaluated. On the basis of its overall profile, (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide ( ...
Tópico(s): Pneumonia and Respiratory Infections
2009 - American Chemical Society | Journal of Medicinal Chemistry
Sònia Sentellas, Israel Ramos, Joan Albertí, Miquel Salvà, Francisca Antón, Montserrat Miralpeix, Jörge Beleta, Amadeu Gavaldà,
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2010 - Elsevier BV | European Journal of Pharmaceutical Sciences
Marcos Valcárcel‐Díaz, P. Carrera-Gómez, Andrea Coronato, Francisco Castillo‐Rodríguez, Jorge Rabassa, Augusto Pérez Albertí,
Abstract A preliminary survey of periglacial landforms found in the Monte Alvear region of the Fuegian Andes, subantarctic Argentina has revealed the presence of nivation hollows, subnival ‘boulder’ (clast) pavements, protalus ramparts, debris lobes, patterned ground and cryo‐ejected clasts. With the exception of debris lobes and cryo‐ejected clasts, all the landforms show some degree of activity and are, therefore, considered as indicators of present‐day cryonival morphodynamics at higher elevations ...
Tópico(s): Geology and Paleoclimatology Research
2006 - Wiley | Permafrost and Periglacial Processes
Daymara Mercerón‐Martínez, William Almaguer‐Melian, Esteban Alberti‐Amador, Bárbara Estupiñán, Isabel Fernández, Jorge A. Bergado,
Tópico(s): Neuroscience and Neural Engineering
2016 - Elsevier BV | Brain Research Bulletin
Jennifer K. King, Nolan Ung, May Paing, Jorge R. Contreras, Michael O. Alberti, Thilini R. Fernando, Kelvin Zhang, Matteo Pellegrini, Dinesh S. Rao,
B-cell development in the bone marrow is followed by specification into functional subsets in the spleen, including marginal zone (MZ) B-cells. MZ B-cells are classically characterized by T-independent antigenic responses and require the elaboration of distinct gene expression programs for development. Given their role in gene regulation, it is not surprising that microRNAs are important factors in B-cell development. Recent work demonstrated that deficiency of the NFκB feedback regulator, miR-146a, ...
Tópico(s): Immune Cell Function and Interaction
2017 - Frontiers Media | Frontiers in Immunology
Carlos L. Hoyos, Silvana P. Cajal, Marisa Juaréz, Jorge D. Marco, Anahí M. Alberti D’Amato, Melina Cayo, I Torrejón, Rubén O. Cimino, Patricio Diosque, Alejandro Krolewiecki, Julio R. Nasser, José F. Gil,
Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the presence of T. cruzi-Leishmania sp. mixed infection in a region of the northwest of Argentina. Methods. Cross- ...
Tópico(s): Trypanosoma species research and implications
2016 - Hindawi Publishing Corporation | BioMed Research International
William Almaguer‐Melian, Daymara Mercerón‐Martínez, Nancy Pavón‐Fuentes, Esteban Alberti‐Amador, Rilda León-Martínez, Nuris Ledón, Susana Delgado Ocaña, Jorge Alberto Bergado Rosado,
Background. Erythropoietin (EPO) upregulates the mitogen activated protein kinase (MAPK) cascade, a central signaling pathway in cellular plastic mechanisms, and is critical for normal brain development. Objective. We hypothesized that EPO could modulate the plasticity mechanisms supporting spatial memory recovery in fimbria-fornix-transected animals. Methods. Fimbria-fornix was transected in 3 groups of rats. Seven days later, EPO was injected daily for 4 consecutive days within 10 minutes after ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2015 - SAGE Publishing | Neurorehabilitation and neural repair
... translations of works by Federico García Lorca, Rafael Alberti, Jorge Guill...
Tópico(s): Translation Studies and Practices
2023 - Johns Hopkins University Press | MLN
... representativos del siglo XX hispanohablantes, a saber, Rafael Alberti, Jorge Guillén y Pablo Neruda, para ser posteriormente comparados ...
Tópico(s): Comparative Literary Analysis and Criticism
2022 - Autonomous University of Madrid | CHIMERA Revista de Corpus de Lenguas Romances y Estudios Lingüísticos
Produção Nacional
Revisado por pares
Emiliano Soares Monteiro, Rodrigo da Rosa Righi, Jorge Luís Victória Barbosa, Antônio Marcos Alberti,
As the world population increases and the need for food monoculture farms are using more and more agrochemicals, there is also an increase in the possibility of theft, misuse, environmental damage, piracy of products, and health problems. This article addresses these issues by introducing the agrochemical pervasive traceability model (APTM), which integrates machine learning, sensors, microcontrollers, gamification, and two blockchains. It contributes in two dimensions: (I) the study of the environmental, ...
Tópico(s): Food Waste Reduction and Sustainability
2021 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Sandrine Passemard, Alain Verloès, Thierry Billette de Villemeur, Odile Boespflug‐Tanguy, Karen Hernandez, Marion Laurent, Bertrand Isidor, Corinne Alberti, Nathalie Pouvreau, Séverine Drunat, Bénédicte Gerard, Vincent El Ghouzzi, Jorge Gallego, Monique Elmaleh, Wieland Β. Huttner, Stéphan Eliez, Pierre Gressèns, Marie Schaer,
Autosomal recessive primary microcephaly results from abnormal brain development linked to proliferation defects in neural progenitors. The most frequent form, caused by ASPM mutations, is usually defined by a reduced brain volume and is associated with intellectual disability. Although many ASPM cases have now been reported, structural brain abnormalities and their link with cognitive disabilities have rarely been investigated. In this study, we used high resolution T1-weighted magnetic resonance ...
Tópico(s): Genomic variations and chromosomal abnormalities
2015 - Elsevier BV | Cortex
Produção Nacional
Patrícia Hadler, Jorge José Cherem, Renata Turbay, Arthur Alberti, Ulyses F. J. Pardiñas,
PALEOENVIRONMENTAL IMPLICATIONS.Despite the increase in knowledge about small mammals from the Holocene of Rio Grande do Sul State and their importance as paleoenvironmental indicators, most assemblages from archaeological sites remains without a detailed analysis.This paper studies the rich small mammals content recovered from the archaeological site RS-C-61: Adelar Pilger, Harmonia, which shows evidence of continuous human occupation throughout the Holocene, from about 8,000 years BP to 3,000 ...
Tópico(s): Wildlife Ecology and Conservation
2016 - | Revista Brasileira de Paleontologia
Claudia Scotta, Carlos Juan, Gabriel Cabot, Antonio Oliver, Jorge Lalucat, Antoni Bennasar-Figueras, Sebastián Albertí,
A total of 10 metallo-β-lactamase-producing isolates of six different species, including Brevundimonas diminuta (n = 3), Rhizobium radiobacter (n = 2), Pseudomonas monteilii (n = 1), Pseudomonas aeruginosa (n = 2), Ochrobactrum anthropi (n = 1), and Enterobacter ludwigii (n = 1), were detected in the sewage water of a hospital. The presence of bla(VIM-13) associated with a Tn1721-class 1 integron structure was detected in all but one of the isolates (E. ludwigii, which produced VIM-2), and in two of them (R. radiobacter), ...
Tópico(s): Water Treatment and Disinfection
2011 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Antônio Marcos Alberti, Mateus Augusto Silva Santos, Ricardo Gabbay de Souza, Hirley Dayan Lourenço da Silva, Jorge Roberto Carneiro, Vitor Alexandre Campos Figueiredo, Joel J. P. C. Rodrigues,
Internet of things (IoT) is pushing the integration of physical and virtual worlds. Sensor devices provide rich sensory information to context-aware services. Actuators implement in the physical world application needs. The role of software is increasing as more and more resources become virtualized and software-defined. Smart environment is an emerging concept that has the potential to address many of the humanity problems. In this context, what are the promising tools for building the smart environments ...
Tópico(s): Caching and Content Delivery
2019 - Institute of Electrical and Electronics Engineers | IEEE Access
Cristina Campos Herrero, Jara Laso, Jorge Cristóbal, Pere Fullana–i–Palmer, Jaume Albertí, Margalida Fullana, Angel Crespo, María Margallo, Rubén Aldaco,
Sustainable tourism should be promoted as a new system for the sustainable management of resources from a socioeconomic and environmental point of view. For this purpose, it is necessary to develop a tool capable of assessing the impacts associated with the sector and to identify which actions are currently being addressed in order to achieve the desired sustainability. This timely study aims to describe the current framework of Life Cycle Assessment (LCA) and its application to the tourism sector. ...
Tópico(s): Energy, Environment, Economic Growth
2022 - Elsevier BV | The Science of The Total Environment
William Almaguer‐Melian, Jorge Bergado-Rosado, Nancy Pavón‐Fuentes, Esteban Alberti‐Amador, Daymara Mercerón‐Martínez, Julietta U. Frey,
Novelty processing can transform short-term into long-term memory. We propose that this memory-reinforcing effect of novelty could be explained by mechanisms outlined in the "synaptic tagging hypothesis." Initial short-term memory is sustained by a transient plasticity change at activated synapses and sets synaptic tags. These tags are later able to capture and process the plasticity-related proteins (PRPs), which are required to transform a short-term synaptic change into a long-term one. Novelty ...
Tópico(s): Memory and Neural Mechanisms
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Jordi Bach, Paul Eastwood, Jacob González, Elena Gómez, Juan Antonio Alonso, Sı́lvia Fonquerna, Estrella Lozoya, Adela Orellana, Mónica Maldonado, Elena Calaf, Joan Albertí, Juan L. Barja, A. G. Andrés Andrés, Neus Prats, Cristina Carreño, Elena Calama, Jorge De Alba, Marta Calbet, Montserrat Miralpeix, Isabel Ramis,
Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of ...
Tópico(s): Medicinal Plant Pharmacodynamics Research
2019 - American Chemical Society | Journal of Medicinal Chemistry
Teresa Serrano Sánchez, Esteban Alberti Amador, Lourdes Lorigados Pedré, Lisette Blanco Lezcano, Iván Díaz Armesto, Jorge A. Bergado,
Brain-derived neurotrophic factor (BDNF) concentration was measured in the striatum and cortex after quinolinic acid intrastriatal lesion and transplantation of bone marrow cells (BMSC). The results showed a significant increase of the BDNF levels in the striatum and cortex of the lesioned animals and the ability of the transplanted cells to increase the levels of BDNF in both sites. This recovery of BDNF production and distribution might have beneficial effects and ameliorate the negative consequences ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2013 - Elsevier BV | Neuroscience Letters
Jorge Jerez Cepa, Rubén Muñoz Pavón, Marcos García Alberti, Angelo Ciccone, Domenico Asprone,
There has been a significant increase in studies related to Industry 4.0 alongside the development of new technologies, devices and software, becoming one of the most relevant topics for years within the so-called Fourth Industrial Revolution (4IR). The Architecture, Engineering and Construction sector (AEC) sector is one step behind other engineering fields in productivity, and digitalisation can help reduce this gap. Building Information Modelling (BIM) implementation in various project phases with ...
Tópico(s): Advanced Manufacturing and Logistics Optimization
2023 - Multidisciplinary Digital Publishing Institute | Applied Sciences