Produção Nacional
Revisado por pares
Jorge Alberto Costa e Silva, N. Puble Alvarez, Guido Mazzotti, Wagner F. Gattaz, Jorge Ospina, Veronica W. Larach, Sergio Starkstein, Daniel Oliva, Lynne Cousins, Mauricio Tohen, Cindy C. Taylor, Jeff Wang, Pierre V. Trân,
Conventional antipsychotic agents can induce extrapyramidal symptoms (EPS) that may be alleviated by switching patients to novel agents such as olanzapine. Patients with schizophrenia and related disorders (ICD-10) who were taking haloperidol (N = 94; mean dose = 12.7 mg/day) and had EPS (Simpson-Angus Scale [SAS] > 3) were directly switched to 6 weeks of open-label olanzapine treatment (mean dose = 11.4 mg/day). There were significant mean improvements (p <0.001 for all measurements) from baseline to endpoint ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2001 - Lippincott Williams & Wilkins | Journal of Clinical Psychopharmacology
Produção Nacional
Revisado por pares
Jorge Alberto Costa e Silva, Ricardo Ewbank Steffen,
Abstract Most of the world's population now lives in cities. While living in cities have both health risks and benefits, mental health has been usually considered to be negatively affected by urbanicity. While mental health disorders have complex etiology and multiple causes, it has been shown in multiple observational studies that mood and anxiety disorders are more prevalent in urban centers and incidence has been increasing. In addition, the incidence of schizophrenia is strongly increased in people ...
Tópico(s): Urban Green Space and Health
2019 - Elsevier BV | Metabolism
Autism is a severe neurodevelopmental disorder that is typically diagnosed by 3 years of age. Core symptoms of autism include profound deficits in social interaction and communication, restricted interests, stereotyped responses, and other repetitive patterns of behavior. Other abnormalities include mental retardation and comorbid epilepsy. These symptoms underscore the consequences of genetic inheritance for brain function and behavior. The etiology of autism may involve an interaction between ...
Tópico(s): Congenital heart defects research
2008 - Elsevier BV | Metabolism
Tópico(s): Circadian rhythm and melatonin
2006 - Elsevier BV | Metabolism
Produção Nacional
Revisado por pares
H. Lôo, Pilar A. Sáiz, Jorge Alberto Costa e Silva, M. Ansseau, R. N. Herrington, Adriano Vaz‐Serra, Horst Dilling, S. De Risio,
Background: Depression is treated by a great variety of antidepressant treatments. SSRIs (such as fluoxetine) are well known: it is, however, sure that further progress is needed and the search for antidepressants with other mechanisms of action (such as tianeptine) or different efficacy is still of interest. Methods: A multinational study compared tianeptine with fluoxetine in 387 patients with Depressive Episode, or Recurrent Depressive Disorder, or Bipolar Affective Disorder (ICD-10), in a double- ...
Tópico(s): Bipolar Disorder and Treatment
1999 - Elsevier BV | Journal of Affective Disorders
Produção Nacional
Revisado por pares
Mohan Isaac, Aleksandar Janča, Kimberly C. Burke, Jorge Alberto Costa e Silva, S W Acuda, Carlo Altamura, Jack D. Burke, C. R. Chandrashekar, Cláudio Torres de Miranda, Gianluigi Tacchin,
The World Health Organization has recently launched an international study of somatoform disorders in different cultures. Five centres representing distinct cultures participated in phase I of the project, the main objective of which was to test the cross-cultural applicability and reliability of instruments for the assessment of somatoform disorders. The analysis of the assessed somatic symptoms showed that various aches and pains in different parts of the body represented cross-culturally the ...
Tópico(s): Empathy and Medical Education
1995 - Karger Publishers | Psychotherapy and Psychosomatics
Hagop S. Akiskal, Jorge Alberto Costa e Silva, Allen Frances, Hugh L. Freeman, Martin B. Keller, Y.D. Lapierre, J J López Ibor, Eugene S. Paykel, M. Stabl,
Background Dysthymia has been reconceptualised in recent years from a personality disorder to a chronic affective disorder. It is incorporated into both the DSM and ICD diagnostic systems. Method. The members of the WPA Dysthymia Working Group combined the results of their manual literature searches with a search using Medline. Results Available data are summarised under the headings of classification, epidemiology, validity, comorbidity, course and outcome, pharmacotherapy and psychotherapy. The ...
Tópico(s): Schizophrenia research and treatment
1995 - Cambridge University Press | The British Journal of Psychiatry
Produção Nacional
Revisado por pares
Irismar Reis de Oliveira, Hélio Elkis, Wagner F. Gattaz, Ana Cristina Chaves, Eduardo Pondé de Sena, Fábio Gomes de Matos e Souza, João Alberto de Oliveira Campos, João Romildo Bueno, Jorge Alberto Costa e Silva, Mário R. Louzã, Paulo Belmonte‐de‐Abreu,
Introduction : Aripiprazole, a dopamine D 2 receptor partial agonist, has also partial agonist activity at serotonin (5-HT) 1A receptors and antagonist activity at 5-HT 2A receptors. Methods : In this 8-week, multicenter, randomized, parallel-group, open-label, flexible-dose study, patients diagnosed with schizophrenia or schizoaffective disorder were randomized to aripiprazole 15–30 mg/day or haloperidol 10–15 mg/day. Results : Patients treated with both aripiprazole and haloperidol improved from baseline ...
Tópico(s): Bipolar Disorder and Treatment
2009 - Cambridge University Press | CNS Spectrums
Produção Nacional
Revisado por pares
The adult brain has more plasticity than previously believed. Neurogenesis, growth and branching of dendrites, and remodeling of synaptic contacts in different regions of the brain occur continuously. Numerous studies have reported a decrease in neuroplasticity in depressed patients and/or in animals subjected to stress and to different models of depression. This has led to the proposal of a new approach to the pathophysiology of depression: depression could be the result of the decrease in neuroplasticity ...
Tópico(s): Functional Brain Connectivity Studies
2004 - Elsevier BV | European Neuropsychopharmacology
Produção Nacional
Revisado por pares
Jorge Alberto Costa e Silva, Ricardo Ewbank Steffen,
Recent advances in deep brain stimulators and brain-machine interfaces have greatly expanded the possibilities of neuroprosthetics and neuromodulation. Together with advances in neuroengineering, nanotechnology, molecular biology and material sciences, it is now possible to address fundamental questions in neuroscience in new, more powerful ways. It is now possible to apply these new technologies in ways that range from augmenting and restoring function to neuromodulation modalities that treat neuropsychiatric ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2017 - Elsevier BV | Metabolism
Produção Nacional
Revisado por pares
Clinical descriptions of depression date back to antiquity. Scientific investigations of mood disorders started only 150 years ago. An historical overview of depression leads into today's knowledge that depressive disorders are common, serious, and sometimes life-threatening and that their effects are persistent and costly. Depressive disorders have a high prevalence, around 5% in the general population, with at least 20% of patients suffering with chronic conditions, such as cardiovascular disease ...
Tópico(s): Neuroendocrine regulation and behavior
2005 - Elsevier BV | Metabolism
... AccessInternational Review of Psychiatry, Volume 1—edited by Jorge Alberto Costa e Silva, M.D., and Carol C. Nadelson, M.D.; ... International Review of Psychiatry, Volume 1—edited by Jorge Alberto Costa e Silva, M.D., and Carol C. Nadelson, M.D.; ...
1994 - American Psychiatric Association | Psychiatric Services
An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
1994 - Cambridge University Press | The British Journal of Psychiatry
An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
1994 - Cambridge University Press | The British Journal of Psychiatry
... ScandinavicaVolume 89, Issue s383 p. 3-3 Preface Jorge Alberto Costa e Silva, Jorge Alberto Costa e Silva World Psychiatric AssociationSearch for more papers by this author Jorge Alberto Costa e Silva, Jorge Alberto Costa e Silva World Psychiatric AssociationSearch for more papers by this ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
1994 - Wiley | Acta Psychiatrica Scandinavica
Produção Nacional
Revisado por pares
Cleber Klasener da Silva, Jorge Alberto Vieira Costa, Michele Greque de Morais,
Tópico(s): Algal biology and biofuel production
2018 - Springer Science+Business Media | Applied Biochemistry and Biotechnology
Produção Nacional
Revisado por pares
Jorge Alberto Bernstein Iriart, Roberval Passos de Oliveira, Shirlei da Silva Xavier, Alane Mendara da Silva Costa, Gustavo Araújo, Vilma Sousa Santana,
Nas últimas décadas, o mercado de trabalho no Brasil tem apresentado um aumento de trabalhadores não registrados. Trabalhadores informais, além de remunerações abaixo do mínimo legal, não contam com seguridade social, e medidas de prevenção de riscos. Este estudo teve por objetivo a análise das representações e percepções sobre a informalidade do contrato de trabalho e dos riscos à saúde entre trabalhadores informais acidentados. A pesquisa foi qualitativa, baseada em entrevistas em profundidade ...
Tópico(s): Occupational Health and Safety in Workplaces
2008 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Bruna da Silva Vaz, Jorge Alberto Vieira Costa, Michele Greque de Morais,
The aim of this study was to develop nanofibers containing nanoparticles with potential for the biological fixation of CO2 together with the microalgae Chlorella fusca LEB 111. An electrospinning technique was used for the production of polymeric nanofibers with different concentrations of iron oxide nanoparticles: 0, 2, 4, 6, 8, and 10% (w v−1). Nanofibers with a nanoparticle concentration of 4% (w v−1) were selected for use in the microalgal cultivation due to their smaller diameter (434 nm), high ...
Tópico(s): Catalytic Processes in Materials Science
2018 - Elsevier BV | Bioresource Technology
Produção Nacional
Revisado por pares
Michele Greque de Morais, Bruna da Silva Vaz, Etiele Greque de Morais, Jorge Alberto Vieira Costa,
Spirulina is produced from pure cultures of the photosynthetic prokaryotic cyanobacteria Arthrospira . For many years research centers throughout the world have studied its application in various scientific fields, especially in foods and medicine. The biomass produced from Spirulina cultivation contains a variety of biocompounds, including biopeptides, biopolymers, carbohydrates, essential fatty acids, minerals, oligoelements, and sterols. Some of these compounds are bioactive and have anti-inflammatory, ...
Tópico(s): Bone Tissue Engineering Materials
2014 - Hindawi Publishing Corporation | BioMed Research International
Produção Nacional
Revisado por pares
Jorge Alberto Vieira Costa, Juliana Botelho Moreira, Bárbara Franco Lucas, Vagner da Silva Braga, Ana Paula Aguiar Cassuriaga, Michele Greque de Morais,
Cyanobacteria are photosynthetic microorganisms known for their high protein content, essential fatty acids, vitamins, and minerals. Due to these features, cyanobacteria biomass can be used as a food supplement and in the production of biofuels, drugs, or biopolymers. Polyhydroxybutyrate (PHB) is a biopolymer belonging to the class of polyhydroxyalkanoates (PHAs) that are produced by heterotrophic bacteria and cyanobacteria. The biosynthesis of PHB by cyanobacteria occurs in the presence of a high ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2018 - Mary Ann Liebert, Inc. | Industrial Biotechnology
Produção Nacional
Costa Coelho Vanessa, Klasener da Silva Cleber, Luiza Terra Ana, Alberto Vieira Costa Jorge, Michele Greque de Morais,
In response to the environmental problems caused by plastics of petrochemical origin, a reduction in the use of these materials and their replacement by biodegradable polymers have been sought. Polyhydroxybutyrate (PHB), a biopolymer of biological origin that belongs to the polyhydroxyalkanoates (PHAs), is similar to polypropylene in terms of its mechanical properties, thermodegradability and melting temperature. Various microorganisms, including cyanobacteria, can synthesize this biopolymer. The ...
Tópico(s): Microplastics and Plastic Pollution
2015 - Academic Journals | African Journal of Microbiology Research
Produção Nacional
Bruna da Silva Vaz, Jorge Alberto Vieira Costa, Michele Greque de Morais,
Nanofibers are materials that present high elasticity, strength, porosity and surface-area-to-volume ratio. The electrospinning method is the most widely adopted technique for forming polymeric nanofibers due to repeatability, easy scale-up process and production of long and continuous nanofibers. This method produces nanofibers with diameters ranging from 10 nm to 1000 nm. The process is regulated by many parameters which significantly affecting the morphology of the nanofibers, and through the ...
Tópico(s): Supercapacitor Materials and Fabrication
2017 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Matéria (Rio de Janeiro)
Produção Nacional
Revisado por pares
Vagner da Silva Braga, Juliana Botelho Moreira, Jorge Alberto Vieira Costa, Michele Greque de Morais,
Fly ashes present several minerals that along with carbon dioxide (CO2) represent a promising nutrient source and an alternative to reduce environmental problems. Thus, the objective of this study was to investigate if CO2, thermoelectric fly ashes and reduction in nitrogen supply alters the production of macromolecules in Chlorella fusca LEB 111. For this purpose, 1.5 or 0.75 g L-1 of NaNO3, injection of 10% (v v-1) of CO2 as well as 0, 40 and 120 ppm of fly ashes were studied. The protein content ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2019 - Elsevier BV | Bioresource Technology
Daiane Angelica Schmatz, Lívia da Silva Uebel, Suelen Goettems Kuntzler, Cristiana Lima Dora, Jorge Alberto Vieira Costa, Michele Greque de Morais,
Polymer nanofibers are nanomaterials that can be used as scaffolds in tissue engineering. The objective of this study was to develop, characterize and evaluate the in vitro degradation of a biomaterial consisting of nanofibers produced from biodegradable and biocompatible polymers with potential applications as a scaffold for tissue regeneration and containing Spirulina sp. LEB 18 biomass as the bioactive compound. The polymers used were poly(hydroxybutyrate-co-hydroxyvalerate) and polycaprolactone. ...
Tópico(s): biodegradable polymer synthesis and properties
2015 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
Produção Nacional
Revisado por pares
Cleber Klasener da Silva, Duna Joanol da Silveira Mastrantonio, Jorge Alberto Vieira Costa, Michele Greque de Morais,
This work describes the development of ultrafine fibers with açaí (Euterpe oleracea Mart.) extract (AE) for use as pH sensors with potential applications in the food industry. The fibers were produced by electrospinning with polymeric solutions composed of 7% (w v−1) polycaprolactone, 2% (w v−1) polyethylene oxide and 3% (w v−1) AE solubilized in chloroform and methanol (3:1). The mean diameter of the fibers was 1635 ± 277 nm, with hydrophilic characteristics (contact angle < 90°), a melting point of 58 °C ...
Tópico(s): Analytical Chemistry and Sensors
2019 - Elsevier BV | Food Chemistry
Produção Nacional
Revisado por pares
Anna Rafaela Cavalcante Braga, Felipe da Silva Figueira, Jéssica Teixeira da Silveira, Michele Greque de Morais, Jorge Alberto Vieira Costa, Susana Juliano Kalil,
C-phycocyanin (C-PC) is a natural blue dye whose uses for different purposes have been described in the literature. Interest in C-PC has increased due to its nutritional and nutraceutical properties that have been exploited for the preparation of food supplements and healthy foods. The goal of this study was to determine the stability of C-PC incorporated into a nanofiber, by obtaining its degradation rate constant (Kd) and half-life (t1/2), as well as to evaluate the role of stabilizing agents. Both ...
Tópico(s): Enzyme Catalysis and Immobilization
2016 - Wiley | Journal of Food Processing and Preservation
Produção Nacional
Revisado por pares
Danielle Cavalcante Ribeiro, Aline D’Ávila Pereira, Fernanda Carvalho de Santana, Jorge Mancini‐Filho, Eduardo Moreira da Silva, Carlos Alberto Soares da Costa, Gilson Teles Boaventura,
Abstract In women, bone mass undergoes changes during pregnancy and the postpartum period, which has a risk for subsequent development of osteoporosis. Thus, the present study aims to evaluate the effects of flaxseed flour in femur quality during post‐weaning of dam rats. After weaning, the rats were divided into control ( C , n = 7) and experimental ( F , n = 7) groups treated with a diet containing 25 g of flaxseed flour in the lactating period and 15 g in the maintenance period. After 51 days post‐partum, ...
Tópico(s): Bone Metabolism and Diseases
2017 - Wiley | Lipids
Produção Nacional
Revisado por pares
Leda G. Ardiles, Yara S. Tadano, Silvano César da Costa, Viviana Urbina, Maurício N. Capucim, Iara da Silva, Alfésio Luı́s Ferreira Braga, Jorge Alberto Martins, Leila Droprinchinski Martins,
Air pollution is currently one of the major environmental risk to human health in the world. Several studies link health to air pollution through the Poisson regression model. However, this study showed that the best method is the regression model with Negative Binomial distribution. The analysis was made based on daily data for the period between 2010 and 2014 regarding hospitalizations due to circulatory and respiratory diseases, stratified by age due to the concentration of air pollutants: CO, ...
Tópico(s): Noise Effects and Management
2017 - Elsevier BV | Atmospheric Pollution Research
Produção Nacional
Revisado por pares
Jorge Alberto Valle da Silva, Lucas Modesto‐Costa, Martijn C. de Koning, Itamar Borges, Tanos C. C. França,
In this work, quaternary and non-quaternary oximes designed to bind at the peripheral site of acetylcholinesterase previously inhibited by organophosphates were investigated theoretically. Some of those oximes have a large number of degrees of freedom, thus requiring an accurate method to obtain molecular geometries. For this reason, the density functional theory (DFT) was employed to refine their molecular geometries after conformational analysis and to compare their 1H and 13C nuclear magnetic ...
Tópico(s): Computational Drug Discovery Methods
2017 - Elsevier BV | Journal of Molecular Structure
Felipe da Silva Figueira, Juliana Garcia Gettens, Jorge Alberto Vieira Costa, Michele Greque de Morais, Caroline Costa Moraes, Susana Juliano Kalil,
C-phycocyanin (C-PC) is a water-soluble phycobiliprotein present in light-harvesting antenna system of cyanobacteria. The nanostructures have not been widely evaluated, precluding improvements in stability and application of the C-PC. Electrospun nanofibers have an extremely high specific surface area due to their small diameter, they can be produced from a wide variety of polymers, and they are successfully evaluated to increase the efficacy of antitumor drugs. The incorporation of C-PC into nanofibers ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2015 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology