José Luis Repetto, Cecilia Cajarville, Jorge D’Alessandro, A. Curbelo, C. Soto, Daniel Garín,
Changes in chemical nitrogen fractions and ruminal degradability of wilted and ensiled temperate forages were studied.Seven cultivated pastures from Uruguayan farms were sampled for their study in each of the following silage-making steps: fresh forage (F), wilted forage (W), and silage (S).Samples were analysed for crude protein (CP), soluble protein in buffer phosphate (SP), and neutral and acid detergent insoluble nitrogen (NDIN and ADIN).The degradability of dry matter (DM) and nitrogen (N) were measured ...
Tópico(s): Botanical Research and Chemistry
2005 - EDP Sciences | Animal Research
Susana Olivares-Rieumont, Daniel de la Rosa, L. Lima, David W. Graham, Katia D′ Alessandro, Jorge Borroto, Francisco Martínez, Julián David Cortés-Sánchez,
The Almendares River watershed covers a large portion of Havana, Cuba and is centrally important to both recreational and other activities in the region. In order to assess current water quality conditions prior to planned remediation efforts, the spatial distribution of six heavy metals and other compounds were determined in river sediments at fifteen sampling stations in the watershed. Metal concentrations in sediments ranged from 86.1 to 708.8 for Zn, 39.3 to 189.0 for Pb, 71.6 to 420.8 for Cu, ...
Tópico(s): Water Quality and Pollution Assessment
2005 - Elsevier BV | Water Research
Eduardo Poggio Fraccari, Oriana D’Alessandro, Jorge Enrique Sambeth, Graciela Baronetti, F. Marino,
Cerium-manganese mixed oxides with different composition were prepared by co-precipitation, characterized and evaluated for the water–gas shift (WGS) reaction. Base metal (5 wt.% Cu and 5 wt.% Ni) catalysts supported on Ce–Mn mixed oxides were also tested for the WGS reaction. The activity of the bare supports is higher in the mixed samples than in pure ceria or manganese oxide. This result can be explained by a combination of greater reducibility and surface area in the mixed samples. Addition of ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2013 - Elsevier BV | Fuel Processing Technology
Produção Nacional
Revisado por pares
Jorge Álvarez, Ennio Bilancini, Simone D’Alessandro, Gabriel Porcile,
In this paper we apply a model of early industrialization to the case of New Zealand and Uruguay in 1870–1940. We show how differences in agricultural institutions may have produced different development paths in two countries which were similar under many respects. While in New Zealand the active role of the Crown in regulating the land market facilitated access to land, in Uruguay land was seized by a small group of large landowners. Our model shows that land concentration may have negatively ...
Tópico(s): Agricultural Economics and Policy
2010 - Elsevier BV | Explorations in Economic History
Marianna Siino, Giada Adelfio, Jorge Mateu, Marcello Chiodi, Antonino D’Alessandro,
Tópico(s): Soil Geostatistics and Mapping
2016 - Springer Science+Business Media | Stochastic Environmental Research and Risk Assessment
Fan He, Angelo B. A. Laranjeira, Tim Kong, Shuyang Lin, Katrina Ashworth, Alice Liu, Nina Lasky, Daniel A.C. Fisher, Maggie J. Cox, Mary C. Fulbright, Lilian Antunes-Heck, LaYow Yu, Molly Brakhane, Bei Gao, Stephen M. Sykes, Angelo D’Alessandro, Jorge Di Paola, Stephen T. Oh,
Platelets from patients with myeloproliferative neoplasms (MPNs) exhibit a hyperreactive phenotype. Here, we found elevated P-selectin exposure and platelet-leukocyte aggregates indicating activation of platelets from essential thrombocythemia (ET) patients. Single-cell RNA-seq analysis of primary samples revealed significant enrichment of transcripts related to platelet activation, mTOR, and oxidative phosphorylation in ET patient platelets. These observations were validated via proteomic profiling. ...
Tópico(s): Kruppel-like factors research
2023 - American Society for Clinical Investigation | Journal of Clinical Investigation
Produção Nacional
Revisado por pares
Juliana Maria Massari, Thayla M. R. de C. Curi, Daniella Jorge de Moura, Brenda Batista Lemos Medeiros, Douglas D’Alessandro Salgado,
RESUMO O “wean to finish” é um sistema de criação de suínos, no qual os animais permanecem em uma mesma instalação do desmame até à fase de abate. Objetivou-se estudar o comportamento dos animais em alojamento exclusivo de 26 machos suínos (T1), misto (T2), contendo 13 machos e 13 fêmeas, e o tratamento único de fêmeas (T3), com 26 animais. Para isso, utilizou-se da análise multivariada, por meio da análise dos gráficos de componentes principais, por ser um artifício interessante utilizado por diversos ...
Tópico(s): Animal Nutrition and Physiology
2015 - Sociedade Brasileira de Engenharia Agrícola | Engenharia Agrícola
Oriana D’Alessandro, Horacio J. Thomas, Jorge Enrique Sambeth,
A series of Mn–Ce(M) solids (M = K or Na), with molar ratios 100–0, 50–50 and 0–100 were prepared by co-precipitation of manganese and cerium nitrate from NaOH or KOH solutions at pH = 11. In addition, part of the solids precipitated with NaOH were dried and impregnated with a Cu2+ salt. The solids were characterized by XRD, Specific Surface Area, XPS and EDS. The characterization analyses show the formation of Mn mixed oxides with different oxidation states (Mn3+, Mn4+), for samples without Ce or Mn– ...
Tópico(s): Radioactive element chemistry and processing
2012 - Springer Science+Business Media | Reaction Kinetics Mechanisms and Catalysis
Oriana D’Alessandro, Ángel G. Sathicq, Jorge Enrique Sambeth, Horacio J. Thomas, Gustavo P. Romanelli,
In this communication, four materials (CeO 2 , CeO 2 (Cu), MnO x , and MnO x (Cu)) were prepared, characterized and tested as catalysts, in solvent-free conditions, for the multicomponent Hantzsch reactions to obtain alternatively the 1,4-dihydropyridine or 2-phenylpyridine depending on the reaction conditions.1,4-Dihydropyridine 4 was the main product formed at 80 °C (76%), and 2-phenylpyridine 7 was the main product at 40 °C (91%), in oxidant-free conditions, using CeO 2 catalyst.It is the first report that ...
Tópico(s): Catalysis for Biomass Conversion
2014 - Elsevier BV | Catalysis Communications
Antonio D’Alessandro, Jorge Lega, Marco Antonio Vera,
SummarySix cases of accidentally diagnosed cystic calcification of the liver were studied. Four of the patients were Colombian and the other two, an Argentinian and a German, had lived in Colombia for years. The calcifications were all very similar and in endemic areas of hydatid disease would have been considered to be calcified hydatids. Five of the patients were alive and in good health but one of the Colombian patients died of a carcinoma of the prostate. A non-specific calcified cyst containing ...
Tópico(s): Congenital Anomalies and Fetal Surgery
1966 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Oriana D’Alessandro, Delfina García Pintos, A. Juan, Beatriz Irigoyen, Jorge Enrique Sambeth,
Density functional theory calculations (DFT + U) were performed on a low doping Mn–Ce composite oxide prepared from experimental data, including X-ray diffraction (XRD) and temperature-programmed reduction (TPR). We considered a 12.5% Mn-doped CeO2 solid solution with fluorite-type structure, where Mn replaces Ce4+ leading to an oxygen-deficient bulk structure. Then, we modeled the adsorption of phenol on the bare Ce0.875Mn0.125O1.9375(1 1 1) surface. We also studied the effect of water adsorption and ...
Tópico(s): Luminescence Properties of Advanced Materials
2015 - Elsevier BV | Applied Surface Science
Nathalie Pezzella–D'Alessandro, Hervé Le Moal, Annie Bonhomme, Audrey Valere, Christophe Klein, Jorge Enrique Gómez‐Marín, Jean‐Michel Pinon,
The gliding motility of the protozoan parasite Toxoplasma gondii and its invasion of cells are powered by an actin-myosin motor. We have studied the spatial distribution and relationship between these two cytoskeleton proteins and calmodulin (CaM), the Ca(2+)-dependent protein involved in invasion by T. gondii. A 3D reconstruction using labeling and tomographic studies showed that actin was present as a V-like structure in the conoidal part of the parasite. The myosin distribution overlapped that ...
Tópico(s): Cytomegalovirus and herpesvirus research
2001 - SAGE Publishing | Journal of Histochemistry & Cytochemistry
Margarida Mendes Jorge, Lucienne Ouermi, Peter Meißner, Guillaume Compaoré, Boubacar Coulibaly, Eric Nébié, Johannes Krisam, Christina Klose, Meinhard Kieser, Albrecht Jahn, Guangyu Lu, Umberto D’Alessandro, Ali Sié, Frank P. Mockenhaupt, Olaf Müller,
Artemisinin resistance is threatening global efforts for malaria control and elimination. Primaquine (PQ) and methylene blue (MB) are gametocytocidal drugs that can be combined with artemisinin-based combination therapy (ACT) to reduce malaria transmission, including resistant strains. Children (6-59 months) with uncomplicated falciparum malaria in Burkina Faso were treated with artesunate-amodiaquine (AS-AQ) and randomized to MB (15 mg/kg/day for 3 days) or PQ (0.25 mg/kg at day 2) with the aim to show ...
Tópico(s): Trypanosoma species research and implications
2019 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Irenilza de Alencar Nääs, Miwa Yamamoto Miragliotta, Marta S. Baracho, Daniella Jorge de Moura, Douglas D’Alessandro Salgado,
A qualidade da cama é responsável pelo acréscimo de produção de gases dentro do interior doaviário. A concentração e o potencial de emissão destes gases estão vinculados a itens comoumidade e pH, que por sua vez são produtos do ambiente interno de alojamento. O objetivoprincipal deste estudo foi avaliar as condições da cama de frango, em função do tipo de alojamentocomercial de frangos de corte adotado: convencional e tipo túnel, com ventilação e densidadepopulacional das aves diferenciados. O galpão ...
Tópico(s): Avian ecology and behavior
2007 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Brasileira de Engenharia de Biossistemas
Produção Nacional
Revisado por pares
Neidimila Aparecida Silveira, Irenilza de Alencar Nääs, Daniella Jorge de Moura, Douglas D’Alessandro Salgado,
A suinocultura brasileira é uma atividade importante para o agronegócio do País. Embora o uso de tecnologia nos vários segmentos dessa atividade envolva a substituição do trabalho humano pela automatização de tarefas, o uso da mão de obra humana ainda é significativo. O trabalhador no setor suinícola está exposto a uma série de fatores de risco na execução de suas atividades, dentre os quais a exposição a gases nocivos. O presente trabalho teve por objetivo avaliar a qualidade do ar em instalações ...
Tópico(s): Aerosol Filtration and Electrostatic Precipitation
2009 - Sociedade Brasileira de Engenharia Agrícola | Engenharia Agrícola
André Bouchot, Jean-David Jaillet, Annie Bonhomme, Nathalie Pezzella-D' Alessandro, Patrice Laquerrière, Laurence Kilian, Henriette Burlet, Jorge Enrique Gómez‐Marín, M Pluot, P. Bonhomme, Jean‐Michel Pinon,
Toxoplasma gondii, the agent causing toxoplasmosis, is an obligate intracellular protozoan parasite. A calcium signal appears to be essential for intracellular transduction during the active process of host cell invasion. We have looked for a Ca2+-transport ATPase in tachyzoites and found Ca2+-ATPase activity (11-22 nmol Pi liberated/mg protein/min) in the tachyzoite membrane fraction. This ATP-dependent activity was stimulated by Ca2+ and Mg2+ ions and by calmodulin, and was inhibited by pump inhibitors ( ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2001 - Japan Society of Cell Biology | Cell Structure and Function
Giulio Cavalli, Isak W. Tengesdal, Mark S. Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez‐Andrés, Raffaella Molteni, Davide Stefanoni, Eleonora Cantoni, Laura Cassina, Silvia Giugliano, Kiki Schraa, Taylor Mills, Eric M. Pietras, Elan Z. Eisenmensser, Lorenzo Dagna, Alessandra Boletta, Angelo D’Alessandro, Leo A. B. Joosten, Mihai G. Netea, Charles A. Dinarello,
Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone post-translational modifications, which enhance production of pro-inflammatory cytokines. As aberrant activation of TI is implicated in inflammatory diseases, tight regulation is critical; however, the mechanisms responsible for this modulation remain elusive. ...
Tópico(s): COVID-19 Impact on Reproduction
2021 - Cell Press | Cell Reports
Lorenzo Siroli, Patricia Burns, F. Borgo, Melisa Puntillo, Silvina R. Drago, Liliana Forzani, Maria Eugenia D’ Alessandro, Jorge Reinheimer, Cristina M. Perotti, Gabriel Vinderola,
Using a mouse model of diet-induced obesity in males and females C57BL/6 mice, effects of a yoghurt enriched with proteins on pro-inflammatory cytokine and lipid profiles were assessed. A clear sex-dependent behaviour of the mice was shown; females gained less weight than males independent of the diet. When a high fat diet was implemented with yoghurt, a reduction of cholesterol and triglycerides in liver and blood serum of males, and triglycerides in the liver of females was observed. For male ...
Tópico(s): Nutrition, Genetics, and Disease
2020 - Elsevier BV | International Dairy Journal
Cecilia Cajarville, Jorge D’Alessandro, Claudia Patricia Lema Soto, A. Curbelo, D. Garín, José Luis Repetto,
Spring excess of temperate pastures are usually ensiled by Uruguayan farmers. The purpose of this work was to study changes in the ruminal N degradability during wilting and silage fermentation of farm forages in Uruguay.
Tópico(s): Agroforestry and silvopastoral systems
2003 - Cambridge University Press | Proceedings of the British Society of Animal Science
Produção Nacional
Revisado por pares
Douglas D’Alessandro Salgado, Irenilza de Alencar Nääs, Danilo Florentino Pereira, Daniella Jorge de Moura,
O estudo de reprodutoras de frangos de corte é de grande importância para o País, uma vez que o frango de corte é um dos maiores itens agropecuários em exportação, sendo o Brasil o segundo maior exportador mundial dessa carne. O comportamento animal é conceituado como reflexo do efeito da interação de diversos fatores, entre os quais o ambiental. Dessa forma, o ambiente interno do galpão de produção constitui um dos elementos que fornecem indicações sobre o conforto térmico das aves. O comportamento ...
Tópico(s): Effects of Environmental Stressors on Livestock
2007 - Sociedade Brasileira de Engenharia Agrícola | Engenharia Agrícola
Produção Nacional
Revisado por pares
João Marcos G. Barbosa, Milenna K. Fernandes Rodrigues, Lurian Caetano David, Taynara C. e Silva, Danielly A. Fortuna Lima, Naiara Zedes Pereira, Emmanuel Bezerra D′Alessandro, Anselmo E. de Oliveira, Paulo Henrique Jorge da Cunha, Maria Clorínda Soares Fíoravantí, Nelson Roberto Antoniosi Filho,
Abstract An innovative volatolomic approach employs the detection of biomarkers present in cerumen (earwax) to identify cattle intoxication by Stryphnodendron rotundifolium Mart., Fabaceae (popularly known as barbatimão). S. rotundifolium is a poisonous plant with the toxic compound undefined and widely distributed throughout the Brazilian territory. Cerumen samples from cattle of two local Brazilian breeds (‘Curraleiro Pé‐Duro’ and ‘Pantaneiro’) were collected during an experimental intoxication protocol ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2020 - Wiley | Biomedical Chromatography
Oriana D’Alessandro, Horacio J. Thomas, Jorge Enrique Sambeth,
Mn–Ce solids were used for the adsorption of phenol from aqueous solution at 25 and 50 °C. The samples were prepared with a Mn–Ce molar ratio between 0 and 100 % by the alkaline co-precipitation method (KOH). Structural studies showed the formation of cryptomelane, Mn2O3, Mn5O8, Mn3O4 and CeO2. The formation of different phases is a function of the Ce concentration. The adsorption isotherms of phenol were determined and modelled with Langmuir and Freundlich equations. Sample 7/3 had a high adsorption ...
Tópico(s): Geochemistry and Elemental Analysis
2014 - Springer Science+Business Media | Reaction Kinetics Mechanisms and Catalysis
Meng‐Han Wu, Felipe Valença-Pereira, Francesca Cendali, Emily Giddings, Catherine Pham‐Danis, Michael Yarnell, A. Novak, Tonya M. Brunetti, Scott B. Thompson, Jorge Henao-Mejía, Richard A. Flavell, Angelo D’Alessandro, M. Eric Kohler, Mercedes Rincón,
Abstract Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically enhance mitochondrial respiration to promote T cell function remain limited. Here, we investigate methylation-controlled J protein (MCJ), an endogenous negative regulator of mitochondrial complex I expressed in CD8 cells, as a target for improving the efficacy of adoptive T cell therapies. We demonstrate that MCJ inhibits mitochondrial ...
Tópico(s): Immune Cell Function and Interaction
2024 - Nature Portfolio | Nature Communications
Meng‐Han Wu, Emily Giddings, Felipe Valença-Pereira, Catherine Pham‐Danis, Francesca Cendali, Michael Yarnell, Amanda Novak, Jorge Henao-Mejía, Richard A. Flavell, Angelo D’Alessandro, M. Eric Kohler, Mercedes Rincón,
... Francesca Cendali, Michael C. Yarnell, Amanda J. Novak, Jorge Henao-Mejia, Richard A. Flavell, Angelo D'Alessandro, Mark Eric Kohler, Mercedes Rincon. Increasing mitochondrial respiration ...
Tópico(s): CAR-T cell therapy research
2024 - American Association for Cancer Research | Cancer Research
Produção Nacional
Revisado por pares
Irenilza de Alencar Nääs, C.E.B. Romanini, Douglas D’Alessandro Salgado, Karla Andréa Oliveira de Lima, Marcos Martinez do Vale, Marcelo Ricardo Labigalini, Silvia Regina Lucas de Souza, Adriana Gomes de Menezes, Daniella Jorge de Moura,
Global warming is affecting agribusiness in its economic aspects. Therefore, the prediction of the evolution of Brazilian beef cattle production cost was made using the IPCC forecast scenario for global warming. The methodology consisted of two steps: (i) the development of a fuzzy model that estimated the grazing land capacity (RP) decrease risk as a function of the changes in the average total rain index, air temperature and increase in extension of the dry season; and (ii) the design of an algorithm ...
Tópico(s): Sustainable Agricultural Systems Analysis
2010 - UNIVERSIDADE DE SÃO PAULO | Scientia Agricola
Produção Nacional
Revisado por pares
Fernando G. Zampieri, Fernando A. Bozza, G. M. Moralez, Débora D. S. Mazza, Alexandre Vaz Scotti, Marcelo S. Santino, Rubens Ribeiro, Édison Moraes Rodrigues Filho, Maurício Magalhães Cabral, Marcelo O. Maia, Patrícia S. D’Alessandro, Sandro V. Oliveira, Márcia A. M. Menezes, Eliana Bernadete Caser, R Lannes, Meton S. Alencar Neto, Maristela Medeiros Machado, Marcelo Ferreira Sousa, Jorge I. Salluh, Márcio Soares,
Tópico(s): Frailty in Older Adults
2016 - Springer Science+Business Media | Intensive Care Medicine
Eleonora Cantoni, I. Merelli, D. Stefanoni, A. Tomelleri, C. Campochiaro, E. Baldissera, Jorge Domínguez‐Andrés, M. Matucci-Cerinic, A. D’alessandro, L. Dagna, M. Netea, Raffaella Molteni, G. Cavalli,
... Corrado Campochiaro: None declared, Elena Baldissera: None declared, Jorge Dominguez Andres: None declared, Marco Matucci-Cerinic: None declared, Angelo D’Alessandro: None declared, Lorenzo Dagna Speakers bureau: SANOFI, NOVARTIS, ...
Tópico(s): Inflammasome and immune disorders
2022 - BMJ | Annals of the Rheumatic Diseases
Luca Lancerotto, Michael S. Chin, Brian B. Freniere, Jorge R. Lujan-Hernandez, Qiong Li, Alessandro Valderrama Vasquez, Franco Bassetto, Daniel A. Del Vecchio, Janice F. Lalikos, Dennis P. Orgill,
... Surgery University of Massachusetts Medical School Worcester, Mass. Jorge R. Lujan-Hernandez, M.D. Qiong Li, M.D. Alessandro Valderrama Vasquez, M.S. Tissue Engineering and Wound ...
Tópico(s): Pressure Ulcer Prevention and Management
2014 - Lippincott Williams & Wilkins | Plastic & Reconstructive Surgery
Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha A. Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, M Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Rubén Fernández‐Rodríguez, Amanda P. Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela Skobe, Marc Veldhoen, Simone Moretti, Silvia C. Formenti, Sandra Demaria, Rajesh K. Soni, Roberta Galarini, Roccaldo Sardella, Grégoire Lauvau, Chaim Putterman, Kari Alitalo, Ursula Grohmann, Laura Santambrogio,
Abstract Tryptophan catabolism is a major metabolic pathway utilized by several professional and non-professional antigen presenting cells to maintain immunological tolerance. Here we report that 3-hydroxy- l -kynurenamine (3-HKA) is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release ...
Tópico(s): Immune Cell Function and Interaction
2021 - Nature Portfolio | Nature Communications
Pavel Davizon‐Castillo, Brandon McMahon, Sonia Águila, David Bark, Katrina Ashworth, Ayed Allawzi, Robert A. Campbell, Emilie Montenont, Travis Nemkov, Angelo D’Alessandro, Nathan Clendenen, Lauren Shih, Natalie A. Sanders, Kelly C. Higa, Allaura Cox, Zavelia Padilla-Romo, Giovanni Hernandez, Eric P. Wartchow, G. Devon Trahan, Eva Nozik‐Grayck, Kenneth L. Jones, Eric M. Pietras, James DeGregori, Matthew T. Rondina, Jorge Di Paola,
Abstract Aging and chronic inflammation are independent risk factors for the development of atherothrombosis and cardiovascular disease. We hypothesized that aging-associated inflammation promotes the development of platelet hyperreactivity and increases thrombotic risk during aging. Functional platelet studies in aged-frail adults and old mice demonstrated that their platelets are hyperreactive and form larger thrombi. We identified tumor necrosis factor α (TNF-α) as the key aging-associated proinflammatory ...
Tópico(s): Immune Cell Function and Interaction
2019 - Elsevier BV | Blood