
Elisa Napolitano Ferreira, Bruna Durães de Figueiredo Barros, Jorge Estefano de Souza, Renan Almeida, Giovana Tardin Torrezan, Sheila Garcia, Ana Cristina Victorino Krepischi, Celso Abdon Lopes de Mello, Isabela Werneck da Cunha, Clóvis Antônio Lopes Pinto, Fernando Augusto Soares, Emmanuel Dias‐Neto, Ademar Lopes, Sandro J. de Souza, Dirce Maria Carraro,
Genome-wide profiling of rare tumors is crucial for improvement of diagnosis, treatment, and, consequently, achieving better outcomes. Desmoplastic small round cell tumor (DSRCT) is a rare type of sarcoma arising from mesenchymal cells of abdominal peritoneum that usually develops in male adolescents and young adults. A specific translocation, t(11;22)(p13;q12), resulting in EWS and WT1 gene fusion is the only recurrent molecular hallmark and no other genetic factor has been associated to this aggressive ...
Tópico(s): Cancer Genomics and Diagnostics
2016 - BioMed Central | Human Genomics

Ana Carolina Kerekes Miguez, Bruna Durães de Figueiredo Barros, Jorge Estefano Santana de Souza, Cecília Maria Lima da Costa, Isabela Werneck da Cunha, Paula Nicole Vieira Pinto Barbosa, Maria Lúcia P. Apezzato, Sandro J. de Souza, Dirce Maria Carraro,
Abstract Tumor DNA has been detected in body fluids of cancer patients. Somatic tumor mutations are being used as biomarkers in body fluids to monitor chemotherapy response as a minimally invasive tool. In this study, we evaluated the potential of tracking somatic mutations in free DNA of plasma and urine collected from Wilms tumor (WT) patients for monitoring treatment response. Wilms tumor is a pediatric renal tumor resulting from cell differentiation errors during nephrogenesis. Its mutational ...
Tópico(s): Renal cell carcinoma treatment
2020 - Wiley | Cancer Medicine

Maria José Rodrigues Vaz, Sônia Maria Oliveira de Barros, Ricardo Palácios, Jorge Figueiredo Senise, L Lunardi, Abês Mahmed Amed, Adauto Castelo,
The objective of the study was to evaluate the influence of pregnancy on the level of adherence with antiretroviral (ARV) drugs, in a prospective cohort of 72 pregnant women and 79 non-pregnant women. Adherence was measured by pill counting and self-reporting. Women were deemed adherent if 95% or more of all ARV had been taken as prescribed, in two occasions. According to pill counting, 43.1 and 17.7% of pregnant and non-pregnant women, respectively, met the criteria of adherence ( P = 0.001); in the ...
Tópico(s): Syphilis Diagnosis and Treatment
2007 - SAGE Publishing | International Journal of STD & AIDS

Giovana Tardin Torrezan, Fernanda G. dos Santos R. de Almeida, Márcia CP Figueiredo, Bruna Durães de Figueiredo Barros, Cláudia Alessandra Andrade de Paula, Renan Valieris, Jorge Estefano Santana de Souza, Rodrigo Fernandes Ramalho, Felipe Cavalcanti Carneiro da Silva, Elisa Napolitano Ferreira, Amanda França de Nóbrega, Paula Silva Felicio, Maria Isabel Achatz, Sandro J. de Souza, Edenir Inêz Palmero, Dirce Maria Carraro,
Pathogenic variants in known breast cancer (BC) predisposing genes explain only about 30% of Hereditary Breast Cancer (HBC) cases, whereas the underlying genetic factors for most families remain unknown. Here, we used whole-exome sequencing (WES) to identify genetic variants associated to HBC in 17 patients of Brazil with familial BC and negative for causal variants in major BC risk genes (BRCA1/2, TP53 and CHEK2 c.1100delC). First, we searched for rare variants in 27 known HBC genes and identified ...
Tópico(s): Cancer Genomics and Diagnostics
2018 - Frontiers Media | Frontiers in Genetics

Bruno Chacon de Figueiredo, Isabela Jorge Trad, Lilian Regina Barros Mariutti, Neura Bragagnolo,
There are few reports about the antioxidant properties of annatto (Bixa orellana), especially considering their antioxidant action in food. In this study we evaluated the antioxidant effect of annatto powder and sodium erythorbate on lipid oxidation in pork loin patties by measuring the secondary products of lipid oxidation, the changes in the fatty acid composition, cholesterol oxidation, and the extent of bixin degradation during storage at − 18 °C for 120 days and subsequent thermal treatment. Sodium ...
Tópico(s): Phytochemicals and Antioxidant Activities
2014 - Elsevier BV | Food Research International

Vilena Barros de Figueirêdo, Cristine Homsi Jorge Ferreira, Jordana Barbosa da Silva, Gláucia Nunes Diniz de Oliveira Esmeraldo, Luiz Gustavo Oliveira Brito, Simony Lira do Nascimento, Patrícia Driusso,
To evaluate the responsiveness of Brazilian-Portuguese version of Pelvic Floor Distress Inventory-20 (PFDI-20) and Pelvic Floor Impact Questionnaire-7 (PFIQ-7) after pelvic floor muscle training (PFMT) in women with stress urinary incontinence (SUI) and mixed urinary incontinence (MUI).This is an observational study with 72 women (51.8 ± 11.9SD years) with SUI (n = 33) and MUI (n = 39). Participants answered PFDI-20 and PFIQ-7 before and after PFMT, which consisted of a 12 weeks protocol supervised by a physiotherapist ...
Tópico(s): Urinary Tract Infections Management
2020 - Elsevier BV | European Journal of Obstetrics & Gynecology and Reproductive Biology

Luan Pereira Diniz, Isadora Matias, Ana Paula Bérgamo Araújo, Matheus Nunes Garcia, Fernanda G. Q. Barros‐Aragão, Soniza Vieira Alves‐Leon, Jorge Marcondes de Souza, Débora Foguel, Cláudia P. Figueiredo, Carolina Braga, Luciana Romão, Flávia Carvalho Alcântara Gomes,
Abstract Parkinson's disease (PD) is characterized by selective death of dopaminergic neurons in the substantia nigra, degeneration of the nigrostriatal pathway, increases in glutamatergic synapses in the striatum and aggregation of α‐synuclein. Evidence suggests that oligomeric species of α‐synuclein (αSO) are the genuine neurotoxins of PD. Although several studies have supported the direct neurotoxic effects of αSO on neurons, their effects on astrocytes have not been directly addressed. Astrocytes ...
Tópico(s): Nerve injury and regeneration
2019 - Wiley | Journal of Neurochemistry

Polyana das Graças Figueiredo Vilela, Jonatas Rafael de Oliveira, Patrícia Pimentel de Barros, Mariella Vieira Pereira Leão, Luciane Dias de Oliveira, Antônio Olavo Cardoso Jorge,
The role of matrix metalloproteinases (MMPs) in tissue degradation has become evident in many diseases and great interest therefore exists in the pharmacological control of the activity of these enzymes. This study evaluated the effect of caffeic acid phenethyl ester (CAPE) on the production of MMPs and their inhibitor (TIMP) in monocytes activated by lipopolysaccharide (LPS). The human monocytic cell line (THP-1) was treated with non-cytotoxic concentrations of CAPE (10 and 60 μM) combined with 1 μg/ ...
Tópico(s): Protease and Inhibitor Mechanisms
2015 - Elsevier BV | Archives of Oral Biology

Helder Pereira de Figueiredo, Cibele Rigolin Pereira de Figueiredo, João Henrique de Souza Barros, Michel Constantino, Fernando Jorge Corrêa Magalhães Filho, Paula Martin de Moraes, Reginaldo Brito da Costa,
Tópico(s): Geography and Environmental Studies
2019 - Springer Science+Business Media | Environmental Monitoring and Assessment

Jordano Brito‐Moreira, Mychael V. Lourenco, Maurício M. Oliveira, Felipe C. Ribeiro, José Henrique Ledo, Luan Pereira Diniz, Juliana F.S. Vital, Margaret H. Magdesian, Helen M. Melo, Fernanda G. Q. Barros‐Aragão, Jorge Marcondes de Souza, Soniza Vieira Alves‐Leon, Flávia Carvalho Alcântara Gomes, Julia R. Clarke, Cláudia P. Figueiredo, Fernanda G. De Felice, Sérgio T. Ferreira,
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2017 - Elsevier BV | Journal of Biological Chemistry

Vilena Barros de Figueirêdo, Simony Lira do Nascimento, Renata Ferreira Lobo Martinez, Clara Taína Silva Lima, Cristine Homsi Jorge Ferreira, Patrícia Driusso,
Abstract Aims To assess the effects of individual pelvic floor muscle (PFM) training vs individual training (IT) progressing to group training (GT) vs group‐only training in women with stress urinary incontinence (SUI). Methods Randomized controlled and pragmatic clinical trials with 90 women with SUI. Participants were randomly allocated to one of three groups: IT, GT, or four individual sessions progressing to group training (IPGT). The intervention included 12 sessions, once a week, with direct supervision ...
Tópico(s): Urinary Tract Infections Management
2020 - Wiley | Neurourology and Urodynamics

Paulo Barbosa, João Paulo Barros, Franklin Ramalho, Lúıs Gomes, Jorge Figueiredo, Filipe Moutinho, Anikó Costa, André S Aranha,
We present a rewriting logic based technique for defining the formal executable semantics of a non-autonomous Petri net class, named Input-Output Place/Transition nets (IOPT nets), designed for model-based embedded system's development, according to the MDA initiative. For this purpose, we provide model-to-model transformations from ecore IOPT models to a rewriting logic specification in Maude. The transformations are defined as semantic mappings based on the respective metamodels: the IOPT metamodel ...
Tópico(s): Real-Time Systems Scheduling
2011 - Springer Science+Business Media | IFIP advances in information and communication technology

Mayara Silva Moura, Ana Flávia Quiarato Lozano, Bruna Marques Tavares, Thamíris Moreira Figueiredo, Jorge Willian Franco de Barros, Lethícia Valencise, Wilma De Grava Kempinas,
Selective serotonin reuptake inhibitors (SSRIs) are prescribed to pregnant women for treating mental illnesses. Among the drugs of this class, sertraline (ST) is the antidepressant therapy recommended most frequently. Therefore, this study aimed to evaluate the impact of gestational ST treatment on reproductive parameters and toxicological target organs of rat female offspring, as well as on somatic, reflex and neurobehavioral development, in a model of maternal adversity. Pregnant Wistar rats received ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2023 - Elsevier BV | Reproductive Toxicology

Josiane de Lima Rosa, Thamíris Moreira Figueiredo, Jorge Willian Franco de Barros, Driéle Bretone dos Santos, Ramão Souza de Deus, Cibele dos Santos Borges, Wilma De Grava Kempinas, Gary Klinefelter,
Infertility affects approximately 15% of couples of reproductive age, and 50% of the cases are directly related to men. The evaluation of male fertility is based on analyses of routine seminal parameters and the use of more advanced techniques can help identify fertility biomarkers. SP22 sperm protein is considered a biomarker in murine species since its concentration is highly correlated with sperm fertility. As the role of this protein as a biomarker is already well-established in other species, ...
Tópico(s): Ovarian function and disorders
2023 - Elsevier BV | Reproductive Toxicology

Mirian Marcolan de Mello, Patrícia Pimentel de Barros, Renata de Cássia Bernardes, Silvio Rubens Alves, Naiara Pires Ramanzini, Lívia Mara Alves Figueiredo-Godoi, Ana Carolina Chipoletti Prado, Antônio Olavo Cardoso Jorge, Juliana Campos Junqueira,
Tópico(s): Antibiotic Resistance in Bacteria
2019 - Springer Science+Business Media | Lasers in Medical Science

Edson Silva Barbosa Leal, Leonardo da Silva Chaves, João Gomes Neto, Paulo Barros de Passos Filho, Daniel de Figueiredo Ramalho, Deoclécio de Queiróz Guerra Filho, Rachel Maria de Lyra Neves, Wallace Rodrigues Telino Júnior, Geraldo Jorge Barbosa de Moura,
Few data are available on the predation of amphibians, reptiles, and mammals by the fringe-lipped bat Trachops cirrhosus (Chiroptera: Phyllostomidae: Phyllostominae), in particular in Brazil, where ecological studies of this species are still incipient. This study presents an overview of the data available in the literature on the composition of the diet of T. cirrhosus, including data from a semiarid region. The first records of the predation of the anurans Corythomanthis greeningi (Hylidae), Pleurodema ...
Tópico(s): Environmental and biological studies
2018 - UNIVERSIDADE DO VALE DO RIO DOS SINOS | Neotropical Biology and Conservation

Vilena Barros de Figueirêdo, Cristine Homsi Jorge Ferreira, Patrícia Driusso,
<p class="abstract"><strong>Background:</strong> <span>Pelvic floor muscle training can be practiced in an individual format or in a group. The research question for this randomised, controlled trial will be: pelvic floor muscle training format including individualized and group training, would be more effective than an individualized training only or groups only? Additionally, it will be evaluated the adherence and follow up (results after 3 and 6 months of the end of training)</ ...
Tópico(s): Male Reproductive Health Studies
2016 - | International Journal of Clinical Trials

Cláudia P. Figueiredo, Fernanda G. Q. Barros‐Aragão, Rômulo Leão Silva Neris, Paula S. Frost, Carolina Soares, Isis Nem de Oliveira Souza, Julianna D. Zeidler, Daniele Coradini Zamberlan, Virginia L. de Sousa, Amanda S. Souza, André Luis de Alcantara Guimarães, Maria Bellio, Jorge Marcondes de Souza, Soniza Vieira Alves‐Leon, Gilda Neves, Heitor A. Paula-Neto, Newton G. Castro, Fernanda G. De Felice, Iranaia Assunção‐Miranda, Julia R. Clarke, Andrea T. Da Poian, Sérgio T. Ferreira,
Abstract Neurological complications affecting the central nervous system have been reported in adult patients infected by Zika virus (ZIKV) but the underlying mechanisms remain unknown. Here, we report that ZIKV replicates in human and mouse adult brain tissue, targeting mature neurons. ZIKV preferentially targets memory-related brain regions, inhibits hippocampal long-term potentiation and induces memory impairment in adult mice. TNF-α upregulation, microgliosis and upregulation of complement system ...
Tópico(s): Primate Behavior and Ecology
2019 - Nature Portfolio | Nature Communications

Veridiana Ester Dias de Barros, Fabiano Pinto Saggioro, Luciano Neder, Rafael Freitas de Oliveira França, Viviane Mariguela, Juliana Helena Chávez, Sandra Penharvel, Jorge Forjaz, Benedito Antônio Lopes da Fonseca, Luiz Tadeu Moraes Figueiredo,
Rocio virus (ROCV) is a flavivirus, probably transmitted by Culex mosquitoes and maintained in nature as a zoonosis of wild birds. Rocio virus caused a human epidemic of severe encephalitis that lasted from 1973 to 1980 in the Ribeira valley, in the southeastern coast of Brazil. After this outbreak, serologic evidence of ROCV circulation has been reported and public health authorities are concerned about a return of ROCV outbreaks in Brazil. We show here a study on the pathogenesis and the physiopathology ...
Tópico(s): Viral Infections and Vectors
2011 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Pedro Gabriel Melo de Barros e Silva, Otávio Berwanger, Dalton Bertolim Précoma, Margaret Assad Cavalcante, José Fernando Vilela-Martin, Estêvão Lanna Figueiredo, Renato D. Lópes, Luiz Carlos Bodanese, Jorge Ilha Guimarães, Jadelson Pinheiro de Andrade, Angêlo Amato Vincenzo de Paola, Marcus Vinícius Bolívar Malachias, Luiz Alberto Mattos, Fernando Bacal, Óscar Pereira Dutra,
Resumo Fundamento Na prática clínica, há evidências de falhas na prescrição de terapias baseadas em evidências para pacientes de alto risco cardiovascular. Entretanto, no Brasil, ainda são insuficientes os dados sobre a evolução ao longo de 1 ano desses pacientes. Objetivos Descrição no acompanhamento de 12 meses da utilização de terapias baseadas em evidência e da ocorrência de desfechos cardiovasculares maiores e seus principais preditores em um registro brasileiro multicêntrico de pacientes de ...
Tópico(s): Public Health in Brazil
2020 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia

Thamíris Moreira Figueiredo, Jorge Willian Franco de Barros, Cibele dos Santos Borges, Tainá Louise Pacheco, Josiane de Lima Rosa, J. A. Anselmo‐Franci, Wilma De Grava Kempinas,
Betamethasone (BM) is the drug of choice for antenatal corticosteroid therapy for women at risk of preterm delivery because it induces fetal lung maturation and enhances survival after birth. However, our group reported evidence of fetal programming and impaired reproductive development and function in rats exposed during the critical window of genital system development. Therefore, we aimed to investigate the effects of BM on the sexual development of rats in the period that corresponds to antenatal ...
Tópico(s): Neonatal Respiratory Health Research
2022 - Wiley | Journal of Applied Toxicology

Michele Elisabete Rúbio Além, Thaís Cristina Chaves, Vilena Barros de Figueirêdo, Ana Carolina Sartorato Beleza, Cristine Homsi Jorge Ferreira, Jordana Barbosa da Silva, Patrícia Driusso,
Abstract Objective The aims of this study were to perform a cross-cultural adaptation of the Vulvovaginal Symptoms Questionnaire (VSQ) into Brazilian Portuguese (VSQ-Br) and evaluate its measurement properties (structural validity, construct validity, internal consistency, and reliability). Methods Cross-cultural adaptation was conducted through the translation, synthesis, and back-translation of the VSQ-Br. Subsequently, 314 women completed the Pelvic Floor Impact Questionnaire, Pelvic Floor Disorders ...
Tópico(s): Anorectal Disease Treatments and Outcomes
2022 - Lippincott Williams & Wilkins | Menopause The Journal of The North American Menopause Society

Filipe Moutinho, Lúıs Gomes, Paulo Barbosa, João Paulo Barros, Franklin Ramalho, Jorge Figueiredo, Anikó Costa, André Monteiro,
This paper shows a methodology for Globally-Asynchronous-Locally-Synchronous (GALS) systems specification and verification. The distributed system is specified by non-autonomous Petri net modules, obtained after the partition of a (global) Petri net model. These modules are represented using IOPT (Input-Output Place-Transition) Petri net models, communicating through dedicated communication channels forming the GALS system under analysis. This set of modules is then automatically translated into Maude ...
Tópico(s): Real-Time Systems Scheduling
2011 - Springer Science+Business Media | IFIP advances in information and communication technology

Maria Fabiene de Sousa Barros, Zafira da Silva de Almeida, Marina Bezerra Figueiredo, Jorge Luíz Silva Nunes, Raimunda Nonata Fortes Carvalho Neta,
O estudo objetivou descrever os aspectos da ecologia trófica e estratégia alimentar da espécie Hassar affinis em dois lagos da Baixada Maranhense, uma zona úmida de interesse ecológico internacional (Sítio Ramsar). Os indivíduos foram coletados mensalmente ao longo de 1 ano. Foram analisados 372 estômagos, onde 246 foram provenientes do Lago Cajari e 126 do Lago de Viana. A composição da dieta da espécie foi analisada pelo método de Frequência de Ocorrência, Volumétrico e índice de Importância alimentar. ...
Tópico(s): Fish Ecology and Management Studies
2021 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development

Régis Munhoz Krás Borges, Roberto Dall’Agnol, Cláudio Nery Lamarão, Marco Aurélio Figueiredo, Albano Antônio da Silva Leite, Carlos Eduardo de Mesquita Barros, Hilton Túlio Costi,
The Paleoproterozoic São Jorge gold deposit is situated in the Tapajós Gold Province of the Amazonian Craton. The deposit is hosted by an amphibole biotite monzogranite, composed of quartz, potassic feldspar, plagioclase, amphibole, biotite, titanite and opaques. Four dominant mineral assemblages were recognized in the deposit. Assemblage 1 was formed during the magmatic stage and is characterized by the presence of amphibole and andesine-oligoclase. Assemblage 2 shows the total replacement of the ...
Tópico(s): Geochemistry and Elemental Analysis
2009 - Sociedade Brasileira de Geologia | Revista Brasileira de Geociências

Vivianni Barros Wanderley, Fernando Luiz Affonso Fonseca, André Quiaios, José Nuno Domingues, Susana Paix�ão, João Paulo Figueiredo, Ana Ferreira, Cleonice de Almeida Pinto, Odair Da Silva, Rogério Alvarenga, Amaury Machi, Eriane Luiz Savóia, Rodrigo Daminello Raimundo,
We are experiencing an unprecedented urbanization process that, alongside physical, social and economic developments, has been having a significant impact on a population’s health. Due to the increase in pollution, violence and poverty, our modern cities no longer ensure a good quality of life so they become unhealthy environments. This study aims to assess the effect of social, environmental and economic factors on the hematologic profile of residents of Santo André’s landfill. In particular, we ...
Tópico(s): Environmental Justice and Health Disparities
2017 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Pedro Jorge Gonçalves Barros, Janine Resende, Antonio Figueiredo Ribeiro, Gumersinda Cancela, Miguel Veloso,
Tópico(s): Cerebral Venous Sinus Thrombosis
2010 - Viguera Publishers | Revista de Neurología

Giovana Tardin Torrezan, Fernanda G. S. R. Almeida, Márcia CP Figueiredo, Bruna D F Barros, Cláudia Alessandra Andrade de Paula, Renan Valieris, Jorge ES Souza, Elisa Napolitano Ferreira, Felipe CC Silva, Amanda França de Nóbrega, Maria Isabel Achatz, Edenir Inêz Palmero, Rodrigo Fernandes Ramalho, Sandro J. de Souza, Dirce Maria Carraro,
Abstract When considering family history, hereditary breast cancer (HBC) syndromes correspond to nearly 5-10% of all breast cancer (BC) cases. However, pathogenic variants in known moderate- and high-risk BC genes explain only ~30% of familial BC cases. Recent advances in sequencing technology resulted in an increasing number of BC genes being revealed in previously negative families by using extended gene panels and whole-exome sequencing (WES). WES offers the opportunity to concomitantly investigate ...
Tópico(s): BRCA gene mutations in cancer
2018 - American Association for Cancer Research | Clinical Cancer Research

Régis Munhoz Krás Borges, Roberto Dall’Agnol, Cláudio Nery Lamarão, Marco Aurélio Figueiredo, Albano Antônio da Silva Leite, Carlos Eduardo de Mesquita Barros, Hilton Túlio Costi,
The Paleoproterozoic Sao Jorge gold deposit is situated in the Tapajos Gold Province of the Amazonian Craton. The deposit is hosted by an amphibole biotite monzogranite, composed of quartz, potassic feldspar, plagioclase, amphibole, biotite, titanite and opaques. Four dominant mineral assemblages were recognized in the deposit. Assemblage 1 was formed during the magmatic stage and is characterized by the presence of amphibole and andesine-oligoclase. Assemblage 2 shows the total replacement of the ...
Tópico(s): Geochemistry and Elemental Analysis
2009 - Sociedade Brasileira de Geologia | Brazilian Journal of Geology
Jorge Henrique Barro, M. V. De Figueiredo,
O artigo explora a importância do cuidado na perspectiva teológica, enfatizando a necessidade de autocuidado e cuidado com os outros por parte dos líderes religiosos. Aborda o cuidado como um tema essencial nas Sagradas Escrituras e como ele se manifesta na criação e na vida de Jesus. A pesquisa destaca a complexidade dos líderes religiosos contemporâneos que assumem múltiplos papéis, incluindo o cuidado com a saúde mental e emocional. Conclui-se que o autocuidado é crucial para uma liderança eficaz ...
Tópico(s): Palliative and Oncologic Care
2024 - | Revista Eclesiástica Brasileira