Produção Nacional
Revisado por pares
Rodrigo Belmonte, Carlos Eduardo Braga Cruz, José R. Pires, Sirlei Daffre,
The antimicrobial activity of hemoglobin fragments (hemocidins) has been reported in a variety of models. The cattle tick Rhipicephalus (Boophilus) microplus is a blood sucking arthropod from where the first in vivo-generated hemocidin was characterized (Hb 33-61). In the present work we identified a novel antimicrobial peptide from the midgut of fully engorged R. (B.) microplus females, which comprises the amino acids 98-114 of the alpha subunit of bovine hemoglobin, and was designated Hb 98-114. This ...
Tópico(s): Vector-borne infectious diseases
2012 - Elsevier BV | Peptides
Leonardo Lorente, María M. Martín, Nerea Varo, Juan M. Borreguero-León, Jordi Solé‐Violán, José Blanquer, Lorenzo Labarta, Cèsar Díaz‐Torné, Alejandro Jiménez, Eduardo Pastor, Felipe Belmonte, Josune Orbe, José Antonio Rodríguez, Eduardo Gómez-Melini, José María Ferrer-Agüero, José Ferreres, Maria C. LLimiñana, José A. Páramo,
Abstract Introduction CD40 Ligand (CD40L) and its soluble counterpart (sCD40L) are proteins that exhibit prothrombotic and proinflammatory properties on binding to their cell surface receptor CD40. The results of small clinical studies suggest that sCD40L levels could play a role in sepsis; however, there are no data on the association between sCD40L levels and mortality of septic patients. Thus, the aim of this study was to determine whether circulating sCD40L levels could be a marker of adverse ...
Tópico(s): Cell Adhesion Molecules Research
2011 - BioMed Central | Critical Care
Patricio A. Díaz, Gonzalo Álvarez, Daniel Varela, Iván Pérez‐Santos, Manuel Díaz, Carlos Molinet, Miriam Seguel, Alejandra Aguilera-Belmonte, Leonardo Guzmán, Eduardo Uribe, José Rengel, Cristina Hernández, C.J. Segura, Rosa Isabel Figueroa,
Tópico(s): Marine Bivalve and Aquaculture Studies
2019 - | Perspectives in Phycology
Rosa Escaño-Marín, Luis M. Pérez‐Belmonte, Eduardo Rodríguez de la Cruz, Juan José Gómez‐Doblas, Eduardo de Teresa–Galván, Manuel F. Jiménez‐Navarro,
En las últimas décadas la mortalidad cardiovascular en Andalucía ha disminuido, al tiempo que la esperanza de vida al nacimiento ha aumentado progresivamente. El objetivo de este trabajo es explicar la contribución a la esperanza de vida al nacimiento del cambio de mortalidad por infarto agudo de miocardio en Andalucía de 1980 a 2014.Diseño ecológico en dos fases: 1980-2001 y 2001-2014. Datos de población y defunciones por causa del Instituto Nacional de Estadística. Se calculan tasas estandarizadas ...
Tópico(s): Climate Change and Health Impacts
2016 - Elsevier BV | Revista Española de Cardiología
Nerea Epelde‐Elezcano, Ruth Prieto‐Montero, Virginia Martínez‐Martínez, María J. Ortiz, Alejandro Prieto‐Castañeda, Eduardo Peña-Cabrera, José L. Belmonte‐Vázquez, Íñigo López‐Arbeloa, Ross Brown, Sylvie Lacombe,
Spherical core–shell silica NPs with fluorescent dyes embedded in the core and Iodo-BODIPYs as new photosensitizers grafted at the external surface were prepared. Their fluorescence and singlet oxygen quantum yields were determined and possible FRET was evaluated.
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2017 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Rosa Escaño-Marín, Luis M. Pérez‐Belmonte, Eduardo Rodríguez de la Cruz, Juan José Gómez‐Doblas, Eduardo de Teresa–Galván, Manuel F. Jiménez‐Navarro,
Sudden cardiac death caused by coronary artery disease (CAD-SCD) is the most frequent cause of SCD in persons < 50 years.The aim of this study was to examine differences in clinical characteristics and autopsy findings of the heart among 18–35 and 36–49 year old CAD-SCD cases.We have previously identified all sudden cardiac deaths in Denmark through review of death certificates and autopsy reports including all deaths between 2000 and 2006 in individuals aged 18–35 years and all deaths between 2007 ...
Tópico(s): Global Public Health Policies and Epidemiology
2016 - Elsevier BV | Revista Española de Cardiología (English Edition)
José María Miguelena Bobadilla, José Ignacio Landa García, Fernando Docobo Durántez, J. García García, Ignacio Iturbe Belmonte, José María Jover Navalón, Eduardo Lobo Martínez, Íñigo López de Cenarruzabeitia, Dieter Morales-García, Mercedes Sanz Sánchez,
El objetivo del estudio intenta realizar una aproximación al estado de la formación quirúrgica en España y analizar su adecuación a los objetivos del programa. Se presentan y se analizan los resultados de dos encuestas realizadas por la Asociación Española de Cirujanos a los residentes y a los tutores de Cirugía General basadas en las conclusiones del XXVII Congreso Nacional de Cirugía. Las cuestiones formuladas hacían referencia a aspectos generales del servicio y particulares en relación con el ...
Tópico(s): Anatomy and Medical Technology
2010 - Elsevier BV | Cirugía Española
Andrea Guerrero‐Corella, Juan Asenjo‐Pascual, Tushar Janardan Pawar, Sergio Díaz‐Tendero, Ana Martín‐Sómer, Clarisa Villegas Gómez, José L. Belmonte‐Vázquez, Diana E. Ramírez‐Ornelas, Eduardo Peña‐Cabrera, Alberto Fraile, David Cruz Cruz, José Alemán,
BODIPY as an EWG in asymmetric catalysis is presented.
Tópico(s): Molecular Sensors and Ion Detection
2019 - Royal Society of Chemistry | Chemical Science
Nelson Giménez‐Agulló, Cristina Sáenz de Pipaón, Louis Adriaenssens, Marta Filibian, Marta Martínez‐Belmonte, Eduardo C. Escudero‐Adán, P. Carretta, Pablo Ballester, José Ramón Galán‐Mascarós,
Abstract Double‐decker complexes of lanthanide cations can be readily prepared with tetraazaporphyrins (porphyrazines). We have synthesized and characterized a series of neutral double‐decker complexes [Ln(OETAP) 2 ] (Ln=Tb 3+ , Dy 3+ , Gd 3+ , Y 3+ ; OETAP=octa(ethyl)tetraazaporphyrin). Some of these complexes show analogous magnetic features to their phthalocyanine (P c ) counterparts. The Tb 3+ and Dy 3+ derivatives exhibit single‐molecule magnet (SMM) behavior with high blocking temperatures over 50 and 10 K, ...
Tópico(s): Lanthanide and Transition Metal Complexes
2014 - Wiley | Chemistry - A European Journal
Samira Husen Alamudi, Dongdong Su, Kyung Jin Lee, Jung Yeol Lee, José L. Belmonte‐Vázquez, Hee-Sung Park, Eduardo Peña‐Cabrera, Young‐Tae Chang,
A palette of background-free tame fluorescent probes were designed and applied to intracellular multi-color labelling in live cells.
Tópico(s): Photochromic and Fluorescence Chemistry
2018 - Royal Society of Chemistry | Chemical Science
Miriam Saiz‐Rodríguez, Carmen Belmonte, José Luis Caniego, Dóra Koller, Pablo Zubiaur, Eduardo Bárcena, Daniel Romero‐Palacián, Eugene A. Kiyatkin, Dolores Ochoa, Francisco Abad‐Santos,
Purpose Clopidogrel is a thienopyridine prodrug that inhibits platelet aggregation. It is prescribed to prevent atherothrombotic and thromboembolic events in patients receiving a stent implant in carotid, vertebral, or cranial arteries. The influence of cytochrome P-450 (CYP) 2C19 on the response to clopidogrel has been widely studied; however, the effect of other genes involved in clopidogrel absorption and metabolism has not been established in this cohort of patients. Methods This observational ...
Tópico(s): Diabetes Treatment and Management
2019 - Elsevier BV | Clinical Therapeutics
Miriam Saiz‐Rodríguez, Daniel Romero‐Palacián, Carlos Villalobos-Vilda, José Luis Caniego, Carmen Belmonte, Dóra Koller, Eduardo Bárcena, María Talegón, Francisco Abad‐Santos,
This observational retrospective study assessed the antiplatelet response and clinical events after clopidogrel treatment in patients who underwent percutaneous neurointervention, related to CYP2C19 metabolizer status (normal (NM), intermediate/poor (IM-PM), and ultrarapid (UM); inferred from *2, *3, and *17 allele determination). From 123 patients, IM-PM had a higher aggregation value (201.1 vs. 137.6 NM, 149.4 UM, P < 0.05) and lower response rate (37.5% vs. 69.8% NM, 61.1% UM), along with higher treatment ...
Tópico(s): Diabetes Treatment and Management
2018 - Wiley | Clinical Pharmacology & Therapeutics
Rongrong Hu, César F. A. Gómez‐Durán, Jacky W. Y. Lam, José L. Belmonte‐Vázquez, Chunmei Deng, Sijie Chen, Ruquan Ye, Eduardo Peña‐Cabrera, Yongchun Zhong, Kam Sing Wong, Ben Zhong Tang,
A series of tetraphenylethene-containing BODIPYs with emissions from visible to near-IR and large Stokes shifts up to 142 nm have been designed and synthesized. They show solvatochromic fluorescence and can be utilized as fluorescent visualizers for intracellular imaging.
Tópico(s): Molecular Sensors and Ion Detection
2012 - Royal Society of Chemistry | Chemical Communications
Produção Nacional
Revisado por pares
José A. Martínez-Álvarez, Laura C. García-Carnero, Paula Kubitschek-Barreira, Nancy E. Lozoya‐Pérez, José L. Belmonte‐Vázquez, José RF de Almeida, Antonio Gómez-Infante, Nathália Curty, Julio C. Villagómez‐Castro, Eduardo Peña‐Cabrera, Iván Martínez-Duncker, Sandro Rogério de Almeida, Leila M. Lopes‐Bezerra, Héctor M. Mora‐Montes,
Aim: Sporothrix schenckii is the causative agent of sporotrichosis. A 70-kDa glycoprotein, Gp70, is a candidate for the development of prophylactic alternatives to control the disease, and its gene (GP70) is predicted to encode for a protein of 43 kDa, contrasting with the molecular weight of the native protein. Materials & methods: The GP70 was expressed in bacteria, the recombinant protein purified, used in immunoassays and injected to Galleria mellonella. Results & conclusion: The recombinant protein ...
Tópico(s): Galectins and Cancer Biology
2019 - Future Medicine | Future Microbiology
Luis M. Pérez‐Belmonte, Juan José Gómez‐Doblas, Mercedes Millán‐Gómez, María D. López-Carmona, Ricardo Guijarro, Fernando Carrasco‐Chinchilla, Eduardo de Teresa–Galván, Manuel F. Jiménez‐Navarro, M. Rosa Bernal‐López, Ricardo Gómez‐Huelgas,
The use of noninsulin antihyperglycaemic drugs in the hospital setting has not yet been fully described. This observational study compared the efficacy and safety of the standard basal-bolus insulin regimen versus a dipeptidyl peptidase-4 inhibitor (linagliptin) plus basal insulin in medicine department inpatients in real-world clinical practice. We retrospectively enrolled non-critically ill patients with type 2 diabetes with mild to moderate hyperglycaemia and no injectable treatments at home who ...
Tópico(s): Diabetes Treatment and Management
2018 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Mario Pérez‐Venegas, Teresa Arbeloa, Jorge Bañuelos, Íñigo López‐Arbeloa, Nancy E. Lozoya‐Pérez, Bernardo Franco, Héctor M. Mora‐Montes, José L. Belmonte‐Vázquez, Claudia I. Bautista‐Hernández, Eduardo Peña‐Cabrera, Eusebio Juaristi,
Abstract Mechanochemistry, that is, the use of mechanical energy produced by milling or grinding to perform chemical transformations, was used as a green strategy using a minimal amount of solvent for the preparation of highly valuable formyl functionalized BODIPY dyes. The electronic properties of the meso ‐aryl group play a key role in the fluorescence response of the adducts resulting from the Ugi reaction. Such an understanding of the molecular structure‐fluorescence interplay explains the brightness ...
Tópico(s): Supramolecular Self-Assembly in Materials
2020 - Wiley | European Journal of Organic Chemistry
Diego García‐González, Verónica Murcia‐Belmonte, Pedro F. Esteban, Felipe Ortega, David Díaz, Irene Sánchez-Vera, Rafael Lebrón‐Galán, Laura Escobar, Luis Martínez‐Millán, Eduardo Weruaga, José Manuel García‐Verdugo, Benedikt Berninger, Fernando de Castro,
Tópico(s): Nerve injury and regeneration
2016 - Springer Science+Business Media | Brain Structure and Function
Diego García‐González, Verónica Murcia‐Belmonte, Pedro F. Esteban, Felipe Ortega, David Díaz, Irene Sánchez-Vera, Rafael Lebrón‐Galán, Laura Escobar, Luis Martínez‐Millán, Eduardo Weruaga, José Manuel García‐Verdugo, Benedikt Berninger, Fernando de Castro,
Tópico(s): Nerve injury and regeneration
2014 - Springer Science+Business Media | Brain Structure and Function
Inmaculada Moreno‐Santos, Luis M. Pérez‐Belmonte, Manuel Macías‐González, María J. Mataró, Daniel Castellano‐Castillo, Miguel A. López-Garrido, Carlos Porras, Pedro L. Sánchez, Juan José Gómez‐Doblas, Fernando Cardona, Eduardo de Teresa–Galván, Manuel F. Jiménez‐Navarro,
Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown. PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD). The CAD-DM2 patients ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2016 - BioMed Central | Journal of Translational Medicine
Luis M. Pérez‐Belmonte, José Pablo Lara, Eduardo Olalla-Mercadé, J. Gutiérrez de Loma, Miguel Ángel Barbancho, Carlos M. San Román-Terán,
La enfermedad coronaria puede actuar como factor de riesgo cognitivo. Se ha estudiado en pacientes programados para cirugía coronaria la presencia de deterioro cognitivo leve disejecutivo. Se ha evaluado en 35 pacientes la función ejecutiva (Trail Making Test). Se clasificaron en grupos con rendimiento normal o con deterioro, estudiándose su relación con otras variables (Mann-Whitney, ji al cuadrado y análisis de regresión múltiple). El grupo con deterioro disejecutivo (n = 7; 20%) presentó mayor grado ...
Tópico(s): Cardiac and Coronary Surgery Techniques
2013 - Elsevier BV | Medicina Clínica
José L. Belmonte‐Vázquez, Edurne Avellanal‐Zaballa, Ernesto Enríquez-Palacios, Luis Cerdán, Ixone Esnal, Jorge Bañuelos, Clarisa Villegas-Gómez, Íñigo López‐Arbeloa, Eduardo Peña‐Cabrera,
We took advantage of the chemoselective meso-functionalization of 2,3,5,6-tetrabromo-8-methylthioBODIPY 6 to prepare a series of 2,3,5,6-tetrabromo-8-arylBODIPY derivatives suitable for SNAr substitution reactions with phenols exclusively at positions 3 and 5. Pd(0)-catalyzed intramolecular arylation reaction ensued on the remaining brominated positions 2 and 6 to give a new family of benzofuran-fused BODIPY dyes. This method utilizes readily available starting materials and allows for the preparation ...
Tópico(s): Nanoplatforms for cancer theranostics
2019 - American Chemical Society | The Journal of Organic Chemistry
Luis M. Pérez‐Belmonte, Inmaculada Moreno‐Santos, Juan José Gómez‐Doblas, José Manuel García‐Pinilla, Luis Morcillo‐Hidalgo, Lourdes Garrido‐Sánchez, Concepción Santiago‐Fernández, María G. Crespo‐Leiro, Fernando Carrasco‐Chinchilla, Pedro L. Sánchez, Eduardo de Teresa–Galván, Manuel F. Jiménez‐Navarro,
Epicardial adipose tissue has been proposed to participate in the pathogenesis of heart failure. The aim of our study was to assess the expression of thermogenic genes (Uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), and PR-domain-missing 16 (PRDM16) in epicardial adipose tissue in patients with heart failure, stablishing the difference according to left ventricular ejection fraction (reduced or preserved). Among the 75 patients in our study, ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2017 - Ivyspring International Publisher | International Journal of Medical Sciences
Lourdes Betancourt-Mendiola, Ismael Valois‐Escamilla, Teresa Arbeloa, Jorge Bañuelos, Íñigo López‐Arbeloa, Juan O. Flores-Rizo, Rongrong Hu, Erik Lager, César F. A. Gómez‐Durán, José L. Belmonte‐Vázquez, Mayra R. Martínez-González, Ismael J. Arroyo‐Córdoba, Carlos A. Osorio-Martı́nez, Enrique Alvarado‐Martínez, Arlette Urías‐Benavides, Brenda D. Gutiérrez‐Ramos, Ben Zhong Tang, Eduardo Peña‐Cabrera,
Several new examples of meso-(het)arylBODIPY were prepared via the Liebeskind-Srogl (L-S) cross-coupling reaction of the Biellmann BODIPYs (1a,b) and aryl- and heteroarylboronic acids in good to excellent yield. It was shown that this reaction could be carried out under microwave heating to shorten reaction times and/or increase the yield. It was illustrated that organostannanes also participate in the L-S reaction to give the corresponding BODIPY analogues in short reaction times and also with good ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2015 - American Chemical Society | The Journal of Organic Chemistry
José L. Belmonte‐Vázquez, Rebeca Sola‐Llano, Jorge Bañuelos, Lourdes Betancourt-Mendiola, Miguel Á. Vázquez, Íñigo López‐Arbeloa, Eduardo Peña‐Cabrera,
Novel modified Biellmann BODIPYs were prepared using a C-H arylation reaction with in-situ formed aryldiazonium salts. The post-functionalization of the methylthio group of these derivatives was demonstrated in SNAr and the Liebeskind-Srogl cross-coupling reactions. The series of compounds herein designed with specific and selective functionalization featuring electron donor and acceptor groups provides valuable information about the impact of the molecular structure and stereoelectronic properties ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2017 - Elsevier BV | Dyes and Pigments
Luis M. Pérez‐Belmonte, Inmaculada Moreno‐Santos, Fernando Cabrera‐Bueno, Gemma Sánchez-Espín, Daniel Castellano‐Castillo, Miguel Such, María G. Crespo‐Leiro, Fernando Carrasco‐Chinchilla, Luis Alonso‐Pulpón, Miguel A. López-Garrido, Amalio Ruíz-Salas, Víctor Manuel Becerra‐Muñoz, Juan José Gómez‐Doblas, Eduardo de Teresa–Galván, Manuel F. Jiménez‐Navarro,
Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP- ...
Tópico(s): Cholesterol and Lipid Metabolism
2017 - Ivyspring International Publisher | International Journal of Medical Sciences
Produção Nacional
Revisado por pares
Carlos Eduardo Farias, José Carlos Bianchi, Paulo Roberto de Oliveira, Paulo César Borges, Euclides Alexandre Bernardelli, Thierry Belmonte, Márcio Mafra,
Plasma cleaning is a promising technology in surface treatments, despite technological interest its use is limited because its mechanisms still are not entirely understood. This work aims to evaluate how the applied power of an inductively coupled RF discharge at 13,56 MHz, with Ar and Ar+10%O2 atmospheres, affects its capabilities to etch an organic molecule. Mass variation rate was used as direct characterization of degradation process and attenuated total reflection-Fourier transform infrared ...
Tópico(s): Surface Modification and Superhydrophobicity
2014 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research
Francisco J. Blanco, Ingrid Möller, Montserrat Romera Baurés, A Rozadilla, J. Sánchez-Lázaro, Ά de Cossío Rodríguez, José Fortes Gálvez, Joaquím Forés, Jordi Monfort, Soledad Ojeda, Carme Moragues, Miguel A. Caracuel, Teresa Clavaguera, Carmen Ayuso Valdés, Josep Soler, C. Orellana, Miguel Ángel Belmonte, Florentina Martín, Sergio Giménez, Eduardo Úcar, Josep A. Pous, Nerea Bartolomé, Marta Artieda, Magdalena Szczypiorska, Diego Tejedor, Antonio Martínez, E. Montell, H. Martínez, Marta Herrero, Josep Vergés,
Objective.The aim of this study was to develop a genetic prognostic tool to predict radiographic progression towards severe disease in primary knee OA (KOA) patients.Methods.This investigation was a cross-sectional, retrospective, multicentric association study in 595 Spanish KOA patients.Caucasian patients aged 540 years at the time of diagnosis of primary KOA of KellgrenLawrence grade 2 or 3 were included.Patients who progressed to KellgrenLawrence score 4 or who were referred for total knee replacement ...
Tópico(s): Tendon Structure and Treatment
2015 - Oxford University Press | Lara D. Veeken
Robinson I. Roacho, Alejandro J. Metta‐Magaña, José L. Belmonte‐Vázquez, Eduardo Peña‐Cabrera, Keith H. Pannell,
Reactions between 8-RS-BODIPY (R = Me, 1) and alkyl and aryl thiols were readily accomplished in dichloromethane to provide a synthetic pathway to a range of new 8-organothio-BODIPYs in good yield. The new alkyl 8-RS-BODIPYs (R = Et, 2; Pr, 3; Bu, 4; t Bu, 5; n-dodecyl, 6) exhibit absorption and emission properties essentially unchanged from those of 1 whereas the arylthio analogs (R = Ph, 7; 2,6-Me 2 C 6 H 3 , 8; p-MeC 6 H 4 , 9; p-MeOC 6 H 4 , 10) exhibit no fluorescence with the exception of 7, and then only ...
Tópico(s): Molecular Sensors and Ion Detection
2015 - NRC Research Press | Canadian Journal of Chemistry
José María Miguelena Bobadilla, José Ignacio Landa García, Fernando Docobo Durántez, J. García García, Ignacio Iturbe Belmonte, José M. Jover Navalón, Eduardo Lobo Martínez, Íñigo López de Cenarruzabeitia, Dieter Morales-García, Mercedes Sanz Sánchez,
The aim of the study is to try and find out the state of surgical training in Spain and to determine whether it meets the objectives of the Program. The results of two surveys carried out on Residents and General Surgery Tutors by the Spanish Surgeons Association, based on the conclusions of the XXVII Congreso Nacional de Cirugía. The questions formulated referred to general aspects of the Service and specific ones related to access, teaching activity, surgery, research and personal perspectives. ...
Tópico(s): Dental Education, Practice, Research
2010 - Elsevier BV | Cirugía Española (English Edition)
Miguel Jerez-Valero, Ana Meliveo-García, Laura Jordán-Martínez, Fernando Carrasco‐Chinchilla, Inmaculada Moreno‐Santos, Antonio Ordóñez, Pedro L. Sánchez, Rafael Vázquez, José M. Hernández-García, Juan José Gómez‐Doblas, Luis M. Pérez‐Belmonte, Eduardo de Teresa–Galván, Manuel F. Jiménez‐Navarro,
Leptin is a plasmatic peptide hormone that has been related to cardiovascular homeostasis and atherosclerosis but much is still unknown about its relationship with coronary artery disease. The aim of this study was to evaluate the value of serum leptin in patients with stable angina and its relationship with the severity of coronary disease.204 patients, 152 with stable angina (coronary artery disease group) and 52 without coronary disease excluded by cardiac computerized tomography (control group) ...
Tópico(s): Adipose Tissue and Metabolism
2016 - Elsevier BV | Medicina Clínica