Luísa Aires, António Teixeira, José Azevedo, María Ivone Gaspar, Sílvia Silva,
El artículo trata de un conjunto de reflexiones sobre las relaciones interpersonales y las emociones en las comunidades virtuales de aprendizaje1. Los referentes teóricos se inspiran en los constructos bajtinianos de alteridad y dialogicidad y se complementan con las perspectivas de Vygotski sobre la construcción social del conocimiento y las emociones. Las relaciones interpersonales en las comunidades virtuales de aprendizaje y, sobretodo, las emociones vivenciadas en estos contextos son estudiadas ...
Tópico(s): Educational Innovations and Technology
2018 - Ediciones Universidad de Salamanca | Education in the Knowledge Society (EKS)
Produção Nacional
Revisado por pares
Daniela Dantas Lima, Renata Cruz Soares de Azevedo, Karla Cristina Gaspar, Viviane Franco da Silva, Marisa Lúcia Fabrício Mauro, Neury José Botega,
OBJETIVO: Detectar fatores associados a histórico de tentativa de suicídio (TS) em pacientes internados em hospital geral que fazem uso nocivo de bebidas alcoólicas. MÉTODO: 4.352 pacientes admitidos consecutivamente foram avaliados utilizando-se um rastreamento do qual constavam as escalas AUDIT (Alcohol Use Disorder Identification Test) e HAD (Escala Hospitalar de Ansiedade e Depressão). Fixando-se histórico de tentativa de suicídio ao longo da vida como variável dependente, foram realizados testes ...
Tópico(s): Health, Nursing, Elderly Care
2010 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Jornal Brasileiro de Psiquiatria
Produção Nacional
Revisado por pares
Pedro Gaspar, José da Silva Moreira, Kátia Kvitko, Martiela Torres, Ana Luiza Schneider Moreira, Tania de Azevedo Weimer,
Gene polymorphisms of phase I (CYP1A1 and CYP2E of cytochrome P,) and phase II (GSTM1, GSTT1 and GSTP1 of glutathione-S-transferase,) enzymes and the TP53 tumor suppressor gene were studied as markers in a sample of 262 Brazilians of European descent, the sample consisting of 97 patients with non-small-cell lung cancer (NSCLC), 75 patients with chronic obstructive pulmonary disease (COPD) and 90 control individuals. For NSCLC, we found no significant relationship between any of the markers studied and ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2004 - Brazilian Society of Genetics | Genetics and Molecular Biology
João Conde, Susana Silva, Ana Paula Azevedo, Valdemar Teixeira, Julieta Esperança Pina, José Rueff, Jorge Gaspar,
Abstract Background MMR is responsible for the repair of base-base mismatches and insertion/deletion loops. Besides this, MMR is also associated with an anti-recombination function, suppressing homologous recombination. Losses of heterozygosity and/or microsatellite instability have been detected in a large number of skin samples from breast cancer patients, suggesting a potential role of MMR in breast cancer susceptibility. Methods We carried out a hospital-based case-control study in a Caucasian ...
Tópico(s): Genomics and Chromatin Dynamics
2009 - BioMed Central | BMC Cancer
Produção Nacional
Revisado por pares
Renata Cruz Soares de Azevedo, Marisa Lúcia Fabrício Mauro, Daniela Dantas Lima, Karla Cristina Gaspar, Viviane Franco da Silva, Neury José Botega,
Tópico(s): Obesity, Physical Activity, Diet
2010 - Elsevier BV | General Hospital Psychiatry
Produção Nacional
Revisado por pares
Vitor Rosetto Muñoz, Rafael Calais Gaspar, Matheus Brandemarte Severino, Ana Paula Azevêdo Macêdo, Fernando Moreira Simabuco, Eduardo R. Ropelle, Dennys E. Cintra, Adelino Sánchez Ramos da Silva, Young‐Bum Kim, José Rodrigo Pauli,
Physical exercise is considered a fundamental strategy in improving insulin sensitivity and glucose uptake in skeletal muscle. However, the molecular mechanisms underlying this regulation, primarily on skeletal muscle glucose uptake, are not fully understood. Recent evidence has shown that Rho-kinase (ROCK) isoforms play a pivotal role in regulating skeletal muscle glucose uptake and systemic glucose homeostasis. The current study evaluated the effect of physical exercise on ROCK2 signaling in skeletal ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2021 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Fernanda Fernandes Souza, Orlando de Castro e Silva, José Antônio Marin‐Neto, Ajith Kumar Sankarankutty, Ana Cláudia Teixeira, Adriano Martinelli, Gilberto Gambero Gaspar, Leônidas Carrijo Azevedo Melo, J F C Figueiredo, Minna Moreira Dias Romano, Benedito Carlos Maciel, A. D. Passos, Marcos A. Rossi,
Chagas disease (American trypanosomiasis) is caused by the protozoan parasite Trypanosoma cruzi. Chagas disease following solid-organ transplantation has occurred in Latin America. This report presents the occurrence of Chagas disease despite negative serological tests in both the donor and the recipient, as well as the effectiveness of treatment. A 21-year-old woman from the state of Sao Paulo (Brazil) underwent cadaveric donor liver transplantation in November 2005, due to cirrhosis of autoimmune ...
Tópico(s): Cardiovascular Issues in Pregnancy
2008 - Elsevier BV | Transplantation Proceedings
Produção Nacional
Revisado por pares
Priscila Caroline Fanger, Renata Cruz Soares de Azevedo, Marisa Lúcia Fabrício Mauro, Daniela Dantas Lima, Karla Cristina Gaspar, Viviane Franco da Silva, Wagner Tadeu Jurevicius Nascimento, Neury José Botega,
OBJETIVO: Determinar as prevalências de depressão e de comportamento suicida em indivíduos com câncer internados em um hospital geral universitário e fatores associados a essas condições. MÉTODOS: O rastreamento de 5357 pacientes consecutivamente internados utilizou a Escala Hospitalar de Ansiedade e Depressão (HAD) e a seção comportamento suicida do Mini International Neuropsychiatric Interview (MINI). Análises univariadas, com ajustes para sexo e faixa etária, foram feitas tomando-se depressão e ...
Tópico(s): Palliative and Oncologic Care
2010 - Brazilian Medical Association | Revista da Associação Médica Brasileira
Luís Silva Santos, SANDRA C. BRANCO, Susana Silva, Ana Paula Azevedo, Octávia Monteiro Gil, Isabel Manita, Teresa Ferreira, Edward Limbert, José Rueff, Jorge Gaspar,
Thyroid cancer (TC) is the most frequent endocrine malignancy, accounting however for only 1-2% of all human cancers, and the best-established risk factor for TC is radiation exposure, particularly during childhood. Since the BER pathway seems to play an important role in the repair of DNA damage induced by IR and other genotoxicants, we carried out a hospital-based case-control study in order to evaluate the potential modifying role of 6 BER polymorphisms on the individual susceptibility to non- ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2012 - Elsevier BV | Oncology Reports
Susana Silva, Rita Moita, Ana Paula Azevedo, Rita Gouveia, Isabel Manita, Julieta Esperança Pina, José Rueff, Jorge Gaspar,
Background: Recent evidence that some DNA-repair functions are haploinsufficient adds weight to the notion that variants in DNA-repair genes constitute part of the spectrum of defects contributing to cancer risk. X-ray repair cross-complementing group 1 gene (XRCC1) is involved in base excision repair (BER) pathway, acting on spontaneous and induced DNA damage. This gene encodes for a scaffolding protein that brings together different proteins involved in the repair process. Among the non-synonymous ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2007 - Elsevier BV | Cancer Detection and Prevention
João Paulo Teixeira, Jorge Gaspar, Susana Silva, Joana Torres, Susana Silva, M. C. Azevedo, Paula Neves, Blanca Laffón, Josefina Méndez, Carla Gonçalves, Olga Mayan, Peter B. Farmer, José Rueff,
Styrene is widely used in the production of various plastics, synthetic rubber and resins. The aim of this study was to evaluate if individual polymorphisms in xenobiotic metabolizing enzymes, related with the metabolic fate of styrene, could modify individual susceptibility to the possible genotoxic effects of the styrene exposure. Twenty-eight reinforced plastic workers and 28 control subjects were studied. In the selected population the urinary styrene metabolites mandelic (MA) and phenylglyoxylic ( ...
Tópico(s): Air Quality and Health Impacts
2003 - Elsevier BV | Toxicology
Luís Silva Santos, Bruno Costa Gomes, Rita Gouveia, Susana Silva, Ana Paula Azevedo, VANESSA CAMACHO, Isabel Manita, Octávia Monteiro Gil, Teresa Ferreira, Edward Limbert, José Rueff, Jorge Gaspar,
Well-differentiated thyroid cancer (DTC) is the most common form of thyroid cancer (TC); however, with the exception of radiation exposure, its etiology remains largely unknown. Several single nucleotide polymorphisms (SNPs) have previously been implicated in DTC risk. Nucleotide excision repair (NER) polymorphisms, despite having been associated with cancer risk at other locations, have received little attention in the context of thyroid carcinogenesis. In order to evaluate the role of NER pathway ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2013 - Elsevier BV | Oncology Reports
Susana Silva, Marta Tomar, Claudia Paulo, Bruno Costa Gomes, Ana Paula Azevedo, Valdemar Teixeira, Julieta Esperança Pina, José Rueff, Jorge Gaspar,
The possible role for DNA repair deficiencies in cancer development, namely in breast cancer has been the subject of increasing interest since it has been reported that breast cancer patients might be deficient in the repair of DNA damage. Exposure to ionizing radiation has been pointed out as a risk factor for breast cancer, and the type of DNA lesions induced by this carcinogen can be repaired by homologous recombination DNA repair (HRR) pathway. To evaluate the potential modifying role of some ...
Tópico(s): BRCA gene mutations in cancer
2009 - Elsevier BV | Cancer Epidemiology
Susana Silva, Marisa Cabral, Guilherme Bezerra de Castro, Marcelo Pires, Ana Paula Azevedo, Isabel Manita, Julieta Esperança Pina, José Rueff, Jorge Gaspar,
Polymorphisms in genes encoding enzymes involved in estrogen metabolism are held to be candidates for associations with breast disease, since there is evidence that circulating estrogens are associated with breast cancer risk. In this study, we evaluated the frequency of different polymorphisms related with estrogen metabolism [COMT Val158Met, CYP17 (5'UTR, T27C); HSD17beta1 Gly313Ser and MnSOD Val16Ala] in a breast cancer resistant population, the Xavante Indians, and the frequencies were compared ...
Tópico(s): Cancer Risks and Factors
2006 - Elsevier BV | Oncology Reports
Hélder Novais Bastos, Mónica Rego Antão, Susana Silva, Ana Paula Azevedo, Isabel Manita, Valdemar Teixeira, Julieta Esperança Pina, Octávia Monteiro Gil, Teresa Ferreira, Edward Limbert, José Rueff, Jorge Gaspar,
Ionizing radiation exposure has been pointed out as a risk factor for thyroid cancer. The double-strand breaks induced by this carcinogen are usually repaired by homologous recombination repair pathway, a pathway that includes several polymorphic genes. Since there is a scarcity of data about the involvement of these gene polymorphisms in thyroid cancer susceptibility, we carried out a case-control study in a Caucasian Portuguese population.We genotyped 109 patients and 217 controls for the XRCC3 ...
Tópico(s): Cancer-related Molecular Pathways
2009 - Mary Ann Liebert, Inc. | Thyroid
Produção Nacional
Revisado por pares
Neury José Botega, Renata Cruz Soares de Azevedo, Marisa Lúcia Fabrício Mauro, Gabriela Nero Mitsuushi, Priscila Caroline Fanger, Daniela Dantas Lima, Karla Cristina Gaspar, Viviane Franco da Silva,
To identify the factors associated with suicide ideation among medically and surgically hospitalized patients.A consecutive sample of 4328 individuals admitted to a general hospital completed a screening questionnaire comprised of demographic and clinical information, the Mini International Neuropsychiatric Interview item on current suicide ideation, the Hospital Anxiety and Depression Scale subscale for depression and the Alcohol use Disorder Identification Test. A multiple logistic regression ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2010 - Elsevier BV | General Hospital Psychiatry
Produção Nacional
Revisado por pares
Neury José Botega, Gabriela Nero Mitsuushi, Renata Cruz Soares de Azevedo, Daniela Dantas Lima, Priscila Caroline Fanger, Marisa Lúcia Fabrício Mauro, Karla Cristina Gaspar, Viviane Franco da Silva,
OBJECTIVE: To determine prevalence rates and identify patient characteristics associated with depression, alcohol use disorders and nicotine dependence among individuals admitted to a general teaching hospital. METHOD: Using the Hospital Anxiety and Depression Scale and Alcohol Use Disorder Identification Test, we assessed 4,352 consecutive medical and surgical patients admitted over a 13-month period. The patients were also asked to report their daily cigarette smoking habits during the last month. ...
Tópico(s): Smoking Behavior and Cessation
2010 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Susana Silva, Octávia Monteiro Gil, Vanessa Cristina de Oliveira Souza, Marisa N. Cabral, Ana Paula Azevedo, Ana Faber, Isabel Manita, Teresa Ferreira, Edward Limbert, Julieta Esperança Pina, José Rueff, Jorge Gaspar,
Abstract The ERCC2 protein is an evolutionary conserved ATP-dependent helicase that is associated with a TFIIH transcription factor complex and plays an important role in nucleotide excision repair. Mutations in this gene are responsible for xeroderma pigmentosum and also for Cocayne syndrome and trichothiodystrophy. Several single nucleotide polymorphisms have been identified in the ERCC2 locus. Among them, a G23591A polymorphism in the codon 312 results in an Asp → Asn substitution in a conserved ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2005 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Cristina Jácome, Ana Margarida Pereira, Rute Almeida, Manuel Ferreira‐Magalhães, Mariana Couto, Luís Araújo, Mariana Pereira, Magna Alves‐Correia, Cláudia Chaves Loureiro, Maria Joana Catarata, Lília Maia Santos, João Gonçalves-Pereira, Bárbara Ramos, Cristina Lopes, Ana Mendes, José Carlos Cidrais Rodrigues, Georgeta Oliveira, Ana Paula Aguiar, Ivete Afonso, Joana Carvalho, Ana Arrobas, José Coutinho Costa, Joana Alves Dias, Ana Todo‐Bom, João Azevedo, Carmelita Ribeiro, Marta Alves, Paula Pinto, Nuno Neuparth, Ana Palhinha, João Gaspar Marques, Nicole Pinto, Pedro Martins, Filipa Todo Bom, Maria Alvarenga Santos, Alberto Costa, Armandina Silva Neto, Marta Santalha, Carlos Lozoya, Natacha Santos, Diana Silva, Maria João Vasconcelos, Luís Taborda‐Barata, Célia Carvalhal, Maria Fernanda Teixeira, Rodrigo Rodrigues Alves, Ana Sofia Moreira, Cláudia Sofia Pinto, Pedro Morais Silva, Carlos Alves, Raquel Câmara, Didina Coelho, Diana Bordalo, Ricardo M. Fernandes, Rosário Ferreira, Fernando Menezes, Ricardo Gomes, Maria José Cálix, Ana Marques, João Cardoso, Madalena Emiliano, Rita Gerardo, Carlos Nunes, Rita Câmara, José Alberto Ferreira, Aurora Carvalho, Paulo Freitas, Ricardo Cruz‐Correia, João Fonseca,
We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.Baseline data from two prospective multicentre observational studies.29 allergy, pulmonology and paediatric secondary care outpatient clinics in Portugal.395 patients (≥13 years old) with persistent asthma.Data on demographics, patient-physician relationship, upper airway control, asthma control, asthma treatment, forced expiratory volume in one second (FEV1) ...
Tópico(s): Cystic Fibrosis Research Advances
2019 - BMJ | BMJ Open
Produção Nacional
Revisado por pares
Marina Pontelo Cristelli, Cláudia Rosso Felipe, Paulo Sergio de Souza Prizmic, Vega Figueiredo Dourado de Azevedo, Laila Almeida Viana, Melissa Gaspar, Daniel Wagner de Castro Lima Santos, Mayara Ivani de Paula, José Medina‐Pestana, Hélio Tedesco‐Silva,
Abstract Objectives To describe the incidence of cytomegalovirus (CMV) infection/disease in kidney transplant recipients receiving an mTOR‐inhibitor‐containing immunosuppressive regimen without prophylactic CMV treatment. Methods This single‐center retrospective cohort analysis included all de novo kidney transplant recipients (09/15/2015‐07/31/2017) receiving 3 mg/kg single dose of rabbit antithymocyte globulin induction, tacrolimus, everolimus, and prednisone. Preemptive therapy was initiated only ...
Tópico(s): Neurological Complications and Syndromes
2019 - Wiley | Clinical Transplantation
Produção Nacional
Revisado por pares
Robson Damasceno de Lima, Renan Fudoli Lins Vieira, Vitor Rosetto Muñoz, Amandine Chaix, Ana Paula Azevêdo Macêdo, Gabriel Calheiros Antunes, Maíra Felonato, Renata Rosseto Braga, Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, Rania A. Mekary, Eduardo R. Ropelle, José Rodrigo Pauli,
Nonalcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of fat in the liver, is estimated to be the most common liver disease worldwide. Obesity is a major risk factor and contributor, and, accordingly, weight loss can improve NAFLD. Previous studies in preclinical models of diet-induced obesity and fatty liver disease have shown the independent benefits of resistance exercise training (RT) and time-restricted feeding (TRF) in preventing weight gain and hepatic build- ...
Tópico(s): Diet and metabolism studies
2023 - American Physiological Society | AJP Endocrinology and Metabolism
Susana Silva, Guilherme Bezerra de Castro, Ana Faber, Marcelo Pires, Vanessa Cristina de Oliveira Souza, Ana Paula Azevedo, Marisa N. Cabral, Isabel Manita, Julieta Esperança Pina, José Rueff, Jorge Gaspar,
Breast cancer is the most common form of cancer in women. Despite the enormous number of cases, the exact causes of breast cancer remain elusive. Recent evidence that some DNA repair functions are haploinsufficient adds weight to the notion that variants in DNA-repair genes constitute part of the spectrum of defects contributing to cancer risk. The ERCC2 polymorphisms C23047G, C23051T, G23591A, and A35931C cause amino acid substitutions (Ile199Met, His201Tyr, Asp312Asn, and Lys751Gln), but there ...
Tópico(s): Genomics and Chromatin Dynamics
2006 - Elsevier BV | Cancer Genetics and Cytogenetics
Susana Silva, Daniela Guerreiro, Mafalda Gomes, Ana Paula Azevedo, Guilherme Bezerra de Castro, José Rueff, Jorge Gaspar,
Tópico(s): Molecular Biology Techniques and Applications
2011 - Elsevier BV | Oncology Reports
Produção Nacional
Revisado por pares
Diana Mota Toro, Pedro V. da Silva‐Neto, Jonatan C. S. de Carvalho, Carlos Alessandro Fuzo, Malena M. Pérez, Vinícius E. Pimentel, Thais Fernanda de Campos Fraga‐Silva, Camilla N. S. Oliveira, Glaucia Rigotto Caruso, Adriana Ferreira Lopes Vilela, Pedro Nobre-Azevedo, Thiago V. Defelippo-Felippe, Jamille Guedes Malta Argolo, Augusto M. Degiovani, Fátima M. Ostini, Marley Ribeiro Feitosa, Rogério Serafim Parra, Fernando Crivelenti Vilar, Gilberto Gambero Gaspar, José Joaquim Ribeiro da Rocha, Omar Féres, Gabriel Peinado Costa, Sandra Regina Maruyama, Elisa Maria de Sousa Russo, Ana Paula Fernandes, Isabel Kinney Ferreira de Miranda Santos, Adriana Malheiro, Ruxana T. Sadikot, Vânia Luiza Deperon Bonato, Cristina Ribeiro de Barros Cardoso, Marcelo Dias‐Baruffi, Átila Alexandre Trapé, Lúcia Helena Faccioli, Carlos A. Sorgi,
SARS-CoV-2 infection triggers distinct patterns of disease development characterized by significant alterations in host regulatory responses. Severe cases exhibit profound lung inflammation and systemic repercussions. Remarkably, critically ill patients display a "lipid storm", influencing the inflammatory process and tissue damage. Sphingolipids (SLs) play pivotal roles in various cellular and tissue processes, including inflammation, metabolic disorders, and cancer. In this study, we employed high- ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2023 - Multidisciplinary Digital Publishing Institute | Cells
Produção Nacional
Revisado por pares
Beatriz Gaspar de Aguiar, José Guilherme Marinho Guerra, Jhonatan Marins Goulart, José Antônio Azevedo Espíndola, Ednaldo da Silva Araújo,
ABSTRACT This study aimed to determine the chemical, physical-chemical properties and agronomic efficiency of fermented composts formulated with agro-industrial wastes and tephrosia (Tephrosia sinapou) phytomass (TS) in arugula fertilization. The experiment was carried out in two phases, using wheat bran (FT), sugarcane bagasse (BC), TS phytomass and malt bagasse (BM) in the compound formulations. The first stage consisted of evaluating the chemical and physical-chemical properties in a completely randomized ...
Tópico(s): Soil Management and Crop Yield
2024 - Associação Brasileira de Olericultura | Horticultura Brasileira
José Pereira Gaspar Filho, Brisa Ricardo Xavier da Silva, José Antônio da Silva, Thalisson Magno de Oliveira, Bruna Karoline de Almeida Santiago, Heitor Costa Azevedo de Lucena, Maria Kaliane Damião Estevam, Francisco Rosa da Rocha, Ana Flávia Costa Eccard, LILIA DE FARIAS MONTEIRO BARBOSA, Joelma Veras da Silva, João Pedro Neto de Sousa,
O objetivo da pesquisa foi realizar uma reflexão crítica sobre as políticas e práticas de saúde no país, identificando lacunas e propondo soluções. Utilizando uma revisão integrativa de literatura, foram abordados aspectos como a contextualização histórica do Sistema Único de Saúde (SUS), os desafios na implementação da universalidade e as oportunidades para sua melhoria. O SUS, criado pela Constituição de 1988, visa garantir acesso universal, integral e equitativo à saúde, porém enfrenta problemas ...
Tópico(s): Health, Nursing, Elderly Care
2024 - | Revista CPAQV - Centro de Pesquisas Avançadas em Qualidade de Vida
José Pereira Gaspar Filho, Brisa Ricardo Xavier da Silva, José Antônio da Silva, Thalisson Magno de Oliveira, Bruna Karoline de Almeida Santiago, Heitor Costa Azevedo de Lucena, Maria Kaliane Damião Estevam, Francisco Rosa da Rocha, Ana Flávia Costa Eccard, LILIA DE FARIAS MONTEIRO BARBOSA, Joelma Veras da Silva, João Pedro Neto de Sousa,
O objetivo da pesquisa foi realizar uma reflexão crítica sobre as políticas e práticas de saúde no país, identificando lacunas e propondo soluções. Utilizando uma revisão integrativa de literatura, foram abordados aspectos como a contextualização histórica do Sistema Único de Saúde (SUS), os desafios na implementação da universalidade e as oportunidades para sua melhoria. O SUS, criado pela Constituição de 1988, visa garantir acesso universal, integral e equitativo à saúde, porém enfrenta problemas ...
Tópico(s): Rural Development and Agriculture
2024 - | Revista CPAQV - Centro de Pesquisas Avançadas em Qualidade de Vida
Produção Nacional
Revisado por pares
Vitor Rosetto Muñoz, Renan Fudoli Lins Vieira, Carlos K. Katashima, Rafael Calais Gaspar, Marsel Lino, Joice Cristina dos Santos Trombeta, Renata Garbellini Duft, Ana Paula Azevêdo Macêdo, Adelino Sánchez Ramos da Silva, Eduardo R. Ropelle, Leandro Pereira de Moura, Dennys E. Cintra, Mara Patrícia Traina Chacon‐Mikahil, Cláudia Regina Cavaglieri, José Rodrigo Pauli,
White adipose tissue (WAT) controls energy storage, expenditure, and endocrine function. Rho-kinase (ROCK) is related to impaired thermogenesis, downregulation of preadipocyte differentiation, and adipokine production. Furthermore, WAT ROCK responds to metabolic stress from high-fat diets or diabetes. However, ROCK distribution in adipose depots and its response to aging and sex remain unclear. Thus, we aim to investigate ROCK function in adipose tissue of rodent and human in response to aging and ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2024 - Oxford University Press | The Journals of Gerontology Series A
Produção Nacional
Revisado por pares
Neury José Botega, Gabriela Nero Mitsuushi, Renata Cruz Soares de Azevedo, Marisa Lúcia Fabrício Mauro, Priscila Caroline Fanger, Daniela Dantas Lima, V.F. Silva, Karla Cristina Gaspar,
Objectives To identify prevalence rates and related patient characteristics associated with depression, alcohol use disorders (AUD), and nicotine dependence among individuals admitted to a university general hospital. Methods 4352 consecutively admitted patients were assessed using the HAD scale and AUDIT. They were also asked on daily cigarette smoking during the previous month. Multivariate logistic regression analyses were performed. Results 56.6% were male. The average age was 49.3. Prevalence ...
Tópico(s): Youth, Drugs, and Violence
2010 - Cambridge University Press | European Psychiatry
Produção Nacional
Revisado por pares
Ana Paula Azevêdo Macêdo, Ivo Vieira de Sousa Neto, Guilherme Correia Ferri Antonio, Rafael Calais Gaspar, Robson Damasceno de Lima, L.M.K. Dias, Renan Fudoli Lins Vieira, Vitor Rosetto Muñoz, Diego Trevisan Brunelli, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Eduardo R. Ropelle, José Rodrigo Pauli,
Tópico(s): Circadian rhythm and melatonin
2025 - Elsevier BV | Nutrition