Produção Nacional
Revisado por pares
Alexandre C.C. Vieira, Danilo Augusto Ferreira Fontes, Luíse Lopes Chaves, Lariza Darlene Santos Alves, José Lourenço de Freitas Neto, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho, Larissa Araújo Rolim, Pedró José Rolim Neto,
Efavirenz (EFZ) is one of the most used drugs in the treatment of AIDS and is the first antiretroviral choice. However, since it has low solubility, it does not exhibit suitable bioavailability, which interferes with its therapeutic action and is classified as a class II drug according Biopharmaceutical Classification System (low solubility and high permeability). Among several drug delivery systems, the multicomponent systems with cyclodextrins and hydrophilic polymers are a promising alternative ...
Tópico(s): Protein purification and stability
2015 - Elsevier BV | Carbohydrate Polymers
Produção Nacional
Revisado por pares
Fábio de Oliveira Silva Ribeiro, Gisele Santos de Araújo, Maria Gabriela Araújo Mendes, Tatiane Caroline Daboit, Lucas Moreira Brito, Cláudia Pessoa, Laís Ramos Monteiro de Lima, Regina C.M. de Paula, Ruan Sousa Bastos, Jefferson Almeida Rocha, Égil de Brito Sá, Thaísa Cardoso de Oliveira, Antônia Carla de Jesus Oliveira, José Lamartine Soares‐Sobrinho, José Roberto de Souza de Almeida Leite, Alyne Rodrigues de Araújo, Durcilene Alves da Silva,
In the present work, we investigated the minimal inhibitory concentration (MIC) against fungal strains (Fonsecaea pedrosoi, Microsporum canis, Candida albicans, Cryptococcus neoformans), and cytotoxicity to normal cell lines for modified red angico gum (AG) with eterifying agent N-chloride (3-chloro-2-hydroxypropyl) trimethylammonium (CHPTAC). Quaternized ammonium groups were linked to AG backbone using N-(3-chloro-2-hydroxypropyl) trimethylammonium chloride. The chemical features of the quaternized ...
Tópico(s): Nanoparticles: synthesis and applications
2020 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Luíse Lopes Chaves, Larissa Araújo Rolim, Maria Luíza Carneiro Moura Gonçalves, Alexandre C.C. Vieira, Lariza Darlene Santos Alves, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho, Maria do Carmo Alves de Lima, Pedró José Rolim Neto,
Tópico(s): Drug Solubulity and Delivery Systems
2012 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
Produção Nacional
Revisado por pares
Lariza Darlene Santos Alves, Mônica Felts de La Roca Soares, Camila Tavares de Albuquerque, E.R. Silva, Alexandre C.C. Vieira, Danilo Augusto Ferreira Fontes, Camila Bezerra Melo Figueirêdo, José Lamartine Soares‐Sobrinho, Pedró José Rolim Neto,
Efavirenz (EFV) used as a part of the treatment of first choice in antiretroviral therapy for AIDS has low aqueous solubility and presents problems of absorption. We thus initially present a phase solubility diagram with carriers of different classes. With a view to obtaining a solid dispersion (SD) with suitable consistency to that of a solid formulation, we chose to use PVP K-30, since polymers present some of the best results. The kneading (KN) and solvent evaporation (EV) methods were thus used ...
Tópico(s): Crystallization and Solubility Studies
2014 - Elsevier BV | Carbohydrate Polymers
Produção Nacional
Revisado por pares
Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho, Keyla Emanuelle Ramos da Silva, Lariza Darlene Santos Alves, Pablo Queiroz Lopes, Lidiane Pinto Correia, Fábio Santos de Souza, Rui Oliveira Macêdo, Pedró José Rolim Neto,
Tópico(s): Polymer crystallization and properties
2011 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
Produção Nacional
Revisado por pares
Camila Bezerra Melo Figueirêdo, Daniela Nadvorny, Amanda Carla Quintas de Medeiros Vieira, José Lamartine Soares‐Sobrinho, Pedró José Rolim Neto, Ping I. Lee, Mônica Felts de La Roca Soares,
Benznidazole (BNZ), the only commercialized antichagasic drug, and the antifungal compound posaconazole (PCZ) have shown synergistic action in the therapy of Chagas disease, however both active pharmaceutical ingredients (APIs) exhibit low aqueous solubility potentially limiting their bioavailability and therapeutic efficacy. In this paper, we report for the first time the formation of a eutectic mixture as well as an amorphous solid solution of PCZ and BNZ (at the same characteristic ratio of 80:20 ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2017 - Elsevier BV | International Journal of Pharmaceutics
Produção Nacional
Revisado por pares
Camila Bezerra Melo Figueirêdo, Daniela Nadvorny, Amanda Carla Quintas de Medeiros Vieira, Giovanna Christinne Rocha de Medeiros Schver, José Lamartine Soares‐Sobrinho, Pedró José Rolim Neto, Ping I. Lee, Mônica Felts de La Roca Soares,
Posaconazole (PCZ) and benznidazole (BNZ) are known to show synergetic effect in treating the acute and chronic phases of Chagas disease, a neglected parasitic disease. However, as both compounds are poorly water soluble, the development of amorphous solid dispersions (ASDs) of a PCZ/BNZ fixed-dose combination in a water-soluble polymer becomes an attractive option to increase their apparent solubility and dissolution rate, potentially improving their oral bioavailability. The initial approach was ...
Tópico(s): Pharmacological Effects of Natural Compounds
2018 - Elsevier BV | European Journal of Pharmaceutical Sciences
Produção Nacional
Revisado por pares
Mirna Luciano de Gois da Silva, Amanda Campos Fortes, Marília Evelyn Rodrigues Oliveira, Rivelilson Mendes de Freitas, Edson C. Silva-Filho, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho, Cleide Maria da Silva Leite,
Tópico(s): Clay minerals and soil interactions
2013 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
Produção Nacional
Revisado por pares
Marciana Socorro Ferreira Cordeiro, Camila Maria B. da Silva, Amanda Carla Quintas de M. Vieira, Daniela Nadvorny, Laisa Lis Fontinele de Sá, Flávia Raquel L. de Souza, Lívio César Cunha Nunes, Edson C. Silva-Filho, Pedró José Rolim Neto, Francisco Veiga, António J. Ribeiro, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
Tópico(s): biodegradable polymer synthesis and properties
2016 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
Produção Nacional
Revisado por pares
Ana Cristina Sousa Gramoza Vilarinho Santana, Daniela Nadvorny, Taisa Daiany da Rocha Passos, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
Cyclodextrins (CDs) are cyclic oligosaccharides capable to improve chemical and physical stability of drugs through formation of drug/CD complexes. In this work, were related the formation of complex inclusion from β-CD and antifungal drug posaconazole (POS) by kneading represented by singular features observed from material amorphization, disorganized surface morphological, elevation of thermal decomposition in relation to β-CD. The inclusion complex formation increased the stability of POS in oxidative ...
Tópico(s): Polysaccharides Composition and Applications
2019 - Elsevier BV | Journal of Drug Delivery Science and Technology
Produção Nacional
Revisado por pares
Amanda Damasceno Leão, Vaeudo Valdimiro de Oliveira, Felipe A. Marinho, Almir Gonçalves Wanderley, Jaciana dos Santos Aguiar, Teresinha Gonçalves da Silva, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
The present research aimed at the synthesis of two new systems containing glibenclamide (GLIB) and double layered hydroxides (LDH). GLIB is an important drug used in the treatment of diabetes mellitus II (DM-II). The choice of zinc LDH (Zn2Al-Cl-GLIB) and magnesium (Mg2Al-Cl-GLIB) was performed with a possible antioxidant action, important for the treatment of DM II. The systems were characterized by x-ray diffractometry, medium infrared spectroscopy, surface area, thermogravimetry and differential exploratory ...
Tópico(s): Magnesium Oxide Properties and Applications
2019 - Elsevier BV | Applied Clay Science
Produção Nacional
Revisado por pares
Antônia Carla de Jesus Oliveira, Emilliany Bárbara Silva, Thaísa Cardoso de Oliveira, Fábio de Oliveira Silva Ribeiro, Daniella Nadvorny, Johny Wysllas de Freitas Oliveira, Ana Borrego‐Sánchez, Klinger Antônio da França Rodrigues, Marcelo Sousa Silva, Pedró José Rolim Neto, César Viseras, Edson C. Silva-Filho, Durcilene Alves da Silva, Luíse Lopes Chaves, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
Nanotechnology is a crucial technology in recent years has resulted in new and creative applications of nanomedicine. Polymeric nanoparticles have increasing demands in pharmaceutical applications and require high reproducibility, homogeneity, and control over their properties. Work explores the use of cashew phthalate gum (PCG) as a particle-forming polymer. PCG exhibited a pH-sensitive behavior due to the of acid groups on its chains, and control drug release. We report the development of nanoparticles ...
Tópico(s): Polysaccharides and Plant Cell Walls
2023 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Yuri Basílio Gomes Patriota, Igor Eduardo Silva Arruda, Antônia Carla de Jesus Oliveira, Thaísa Cardoso de Oliveira, Eliadna de Lemos Vasconcelos Silva, Luíse Lopes Chaves, Fábio de Oliveira Silva Ribeiro, Durcilene Alves da Silva, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
Tópico(s): Inhalation and Respiratory Drug Delivery
2021 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Júlia Samara Ferreira da Silva, Antônia Carla de Jesus Oliveira, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
Trees of the genus Sterculia produce polysaccharide-rich exudates, such as karaya gum (Sterculia urens), chicha gum (Sterculia striata), and Sterculia foetida gum. These anionic biomaterials are biodegradable, with high viscosity, low toxicity, and gelling properties in aqueous media. According to these properties, they show promising applications as a polymer matrix for use in drug delivery systems. For this application, both the chemically modified and the unmodified polysaccharide are used. This ...
Tópico(s): Proteins in Food Systems
2021 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Thaísa Cardoso de Oliveira, Antônia Carla de Jesus Oliveira, Yuri Basílio Gomes Patriota, Luíse Lopes Chaves, Fábio de Oliveira Silva Ribeiro, Regina C.M. de Paula, Edson C. Silva-Filho, Durcilene Alves da Silva, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
We developed a new hydrophobic polymer based on angico gum (AG), and we produced new nanoparticles to expand the applications of natural polysaccharides in nanomedicine. Phthalate angico gum (PAG) was characterized by 1H NMR, FTIR, elementary analysis, solubility, XRD, and TG. PAG was a hydrophobic and semi-crystalline material, a relevant characteristic for drug delivery system applications. As a proof of concept, nevirapine (NVP) was selected for nanoparticles development. Plackett-Burman's experimental ...
Tópico(s): Polysaccharides Composition and Applications
2021 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Danilo Augusto Ferreira Fontes, Magaly Andreza Marques de Lyra, Jeyce Kelle Ferreira de Andrade, Giovanna Christinne Rocha de Medeiros Schver, Larissa Araújo Rolim, Teresinha Gonçalves da Silva, José Lamartine Soares‐Sobrinho, Severino Alves, Pedró José Rolim Neto,
Tópico(s): Mesoporous Materials and Catalysis
2016 - Springer Science+Business Media | Journal of Inclusion Phenomena and Macrocyclic Chemistry
Ádley Antonini Neves de Lima, José Lamartine Soares‐Sobrinho, Roberto A.C. Corrêa, Pedró José Rolim Neto,
SUMMARY. The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. The basis for this popularity from a pharmaceutical standpoint, is the ability of these ...
Tópico(s): Analytical Chemistry and Chromatography
2008 - College of Pharmacists of Buenos Aires Province | Latin American Journal of Pharmacy
Produção Nacional
Revisado por pares
Dayanne Tomaz Casimiro da Silva, Igor Eduardo Silva Arruda, Leandro M. França, Denise B. França, Maria G. Fonseca, Mônica Felts de La Roca Soares, César Viseras, José Lamartine Soares‐Sobrinho,
A new nano system based on drug/clay minerals is sought as an alternative to the current options due to the limitations of the conventional treatment. In this study, experimental conditions, such as pH, reaction duration and initial drug concentration, were evaluated to obtain systems based on the anticancer drug tamoxifen (TMX) and montmorillonite. Equilibrium and kinetic studies were developed for montmorillonite (VHS)/TMX at pH values in the range of 1.5 to 7.0 for reaction times of 1 to 720 min ...
Tópico(s): Adsorption and biosorption for pollutant removal
2019 - Elsevier BV | Applied Clay Science
Produção Nacional
Revisado por pares
Janira M. N. A. Bezerra, Antônia Carla de Jesus Oliveira, Edson C. Silva-Filho, Patrícia Severino, Selma B. Souto, Eliana B. Souto, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
Polyelectrolytic complexation has stood out due to its application in the development of drug delivery systems using biopolymers as raw materials. The formation of complexes between cashew gum and chitosan can be intermediated by cross-links, mediated by the action of the sodium tripolyphosphate crosslinking agent. These polymers have been used in the nanotechnological development of formulations to protect peptide drugs, such as insulin, allowing their oral administration. In this work, we describe ...
Tópico(s): Nanocomposite Films for Food Packaging
2021 - Multidisciplinary Digital Publishing Institute | Diabetology
Produção Nacional
Revisado por pares
Eliadna de Lemos Vasconcelos Silva, Antônia Carla de Jesus Oliveira, Yuri Basílio Gomes Patriota, António J. Ribeiro, Francisco Veiga, Fernando Hallwass, Edson C. Silva-Filho, Durcilene Alves da Silva, Mônica Felts de La Roca Soares, Almir Gonçalves Wanderley, José Lamartine Soares‐Sobrinho,
Cashew gum (CG) is a biopolymer that presents a favorable chemical environment for structural modifications, which leads to more stable and resistant colloidal systems. The gum was subjected to an acetylation reaction using a fast, simple, solvent-free and low cost methodology. The derivative was characterized by infrared and NMR spectroscopy, elemental analysis, coefficient of solubility and zeta potential. The modified biopolymer was used as a platform for drug delivery systems using insulin as ...
Tópico(s): Biofuel production and bioconversion
2018 - Elsevier BV | Carbohydrate Polymers
Produção Nacional
Revisado por pares
José Lamartine Soares‐Sobrinho, Mônica Felts de La Roca Soares, Pedró José Rolim Neto, Juan J. Torres‐Labandeira,
Tópico(s): Carbohydrate Chemistry and Synthesis
2010 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
Produção Nacional
Revisado por pares
Larissa Araújo Rolim, Flávia Cassia Maria dos Santos, Luíse Lopes Chaves, Maria Luíza Carneiro Moura Gonçalves, José Lourenço Freitas-Neto, André Luiz da Silva do Nascimento, José Lamartine Soares‐Sobrinho, Miracy Muniz de Albuquerque, Maria do Carmo Alves de Lima, Pedró José Rolim Neto,
Tópico(s): Essential Oils and Antimicrobial Activity
2014 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
Produção Nacional
Revisado por pares
Eliadna de Lemos Vasconcelos Silva, Antônia Carla de Jesus Oliveira, Lívia Maria Coelho de Carvalho Moreira, Edson C. Silva-Filho, Almir Gonçalves Wanderley, Mônica Felts de La Roca Soares, José Lamartine Soares‐Sobrinho,
Insulin is one of the most important drugs in the clinical treatment of diabetes. There is growing interest in oral insulin administration as it mimics the physiological pathway and potentially reduces side effects associated with subcutaneous injection. In this study, a nanoparticulate system was developed using acetylated cashew gum (ACG) and chitosan by the polyelectrolyte complexation method, for oral administration of insulin. The nanoparticles were characterized by size, zeta potential and ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2023 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Dayanne Tomaz Casimiro da Silva, Maria G. Fonseca, Ana Borrego‐Sánchez, Mônica Felts de La Roca Soares, César Viseras, C. Ignacio Sainz‐Díaz, José Lamartine Soares‐Sobrinho,
Tópico(s): Iron oxide chemistry and applications
2020 - Elsevier BV | Microporous and Mesoporous Materials
Produção Nacional
Revisado por pares
Márcia Rocha de Freitas, Larissa Araújo Rolim, Mônica Felts de La Roca Soares, Pedró José Rolim Neto, Miracy Muniz de Albuquerque, José Lamartine Soares‐Sobrinho,
Olanzapine (OLP), the most important atypical antipsychotic drug of the new generation, a high cost drug, has low aqueous solubility, affecting its dissolution and absorption. Its complexation with modified cyclodextrins (CDs) is designed to achieve novel vectorization systems with higher solubility, consequently higher bioavailability. From the CD selection, among β-CD, methyl-β-CD (MβCD) and hydroxypropyl-β-CD, it was obtained a phase solubility diagram suggesting a 1:1 (mol:mol) OLP–CD stoichiometry ...
Tópico(s): Analytical Chemistry and Chromatography
2012 - Elsevier BV | Carbohydrate Polymers
Magalí A. M. de Lyra, José Lamartine Soares‐Sobrinho, Mariana T. Brasileiro, Mónica F. de La Roca, Javier A. Barraza, Viana Osnir de Sá, Pedró José Rolim Neto,
Tópico(s): Advanced Drug Delivery Systems
2007 - College of Pharmacists of Buenos Aires Province | Latin American Journal of Pharmacy
Produção Nacional
Revisado por pares
António J. Ribeiro, Flávia Raquel L. de Souza, Janira M. N. A. Bezerra, Cláudia Oliveira, Daniela Nadvorny, Mônica Felts de La Roca Soares, Lívio César Cunha Nunes, Edson C. Silva-Filho, Francisco Veiga, José Lamartine Soares‐Sobrinho,
The development of delivery systems using natural polymers such as gums offers distinct advantages, such as, biocompatibility, biodegradability, and cost effectiveness. Cashew gum (CG) has rheological and mucoadhesive properties that can find many applications, among which the design of delivery systems for drugs and other actives such as larvicide compounds. In this review CG is characterized from its source through to the process of purification and chemical modification highlighting its physicochemical ...
Tópico(s): Ginkgo biloba and Cashew Applications
2016 - Elsevier BV | Carbohydrate Polymers
Produção Nacional
Revisado por pares
José Lamartine Soares‐Sobrinho, Mônica Felts de La Roca Soares, Pablo Queiroz Lopes, Lidiane Pinto Correia, Fábio Santos de Souza, Rui Oliveira Macêdo, Pedró José Rolim Neto,
This work aimed the studies of physicochemical characterization, thermal stability, and compatibility of benznidazole (BNZ) drug by spectroscopy (NMR, IR), thermoanalytical (differential thermal analysis, differential scanning calorimetry, and thermogravimetry), and chromatographic (HPLC) techniques, beyond the analytical tools of Van't Hoff equation and Ozawa model. The compatibility study was conducted by binary mixtures (1:1, w/w) of the drug with microcrystalline cellulose 102 and 250, anhydrous ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2010 - Springer Science+Business Media | AAPS PharmSciTech
Produção Nacional
Revisado por pares
Ádley Antonini Neves de Lima, José Lamartine Soares‐Sobrinho, Jeckson L. Silva, Roberto A.C. Corrêa-Júnior, Magaly Andreza Marques de Lyra, Fabiana L. A. Santos, Boaz G. Oliveira, Marcelo Zaldini Hernandes, Larissa Araújo Rolim, Pedró José Rolim Neto,
ABSTRACT The present study investigates the release mechanism of benznidazole (BNZ) in solid dispersions with polyethylene glycol 6000 (PEG 6000) and polyvinylpirrolydone K-30 (PVP K-30), with a view to observing the increase in solubility of BNZ in water in the presence of these two hydrophilic polymers. The interaction of BNZ with the polymers was evaluated using scanning electron microscopy, Fourier-transformation infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and in vitro ...
Tópico(s): Poisoning and overdose treatments
2011 - Elsevier BV | Journal of Pharmaceutical Sciences
Produção Nacional
Magaly Andreza Marques de Lyra, José Lamartine Soares‐Sobrinho, Regina Célia Bressan Queiroz de Figueiredo, Jana Messias Sandes, Ádley Antonini Neves de Lima, Rômulo P. Tenório, Danilo Augusto Ferreira Fontes, Fabiana L. A. Santos, Larissa Araújo Rolim, Pedró José Rolim Neto,
Tópico(s): HIV/AIDS drug development and treatment
2011 - Springer Science+Business Media | Journal of inclusion phenomena and molecular recognition in chemistry