Andrew Robson, Phil Yates, Tom Baldwin and David Charter, DJM, Adam Sherwin Media Reporter, Sean MacUlay, Tom Dyckhoff, Frances Gibb Legal Editor, Antonla Senior, Gordon Turner, Karl MacKie, Tim Sisson, Philip Howard, Hilary Finch, David Chater, Tom Bawden and Christine Seib, H. Gilzean-Reid, Gabrielle Starkey, Chris Stoddart, Geoff Brown, Sam Lister, Nick Szczepanlk, Joe Joseph, Andrew Norfolk, Ann Williams, Edward R. Howard Clinial Director, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Tom Bawden, Dominic Walsh, Shirley English, A. J. Perry, Leo Lewis and Richard Lloyd Parry, Jane Clifton, Patick Strong, Bolton, Jill Dupleix, Tim Reid, Dalya Alberge Arts Correspondent, John Irwin, Libby Purves, Robin Young, Alan Hamilton, Stephen Farrell, Oliver Wright Health Correspondent, James Delingpole, David Hands, Charles Bremner, Matt Dickinson Chief Football Correspondent, Bronwen Maddox Foreign Editor's Briefing, David Rowan, Edward Fennell, Angus Bishop, David Meredith, Richard Bruton, John Westerby, Michael Theodoulou, David Nettleton, Stephen Burgen, Gary Slapper, John Hopkins Golf Correspondent, Gabriel Rozenberg, Ann Treneman Parliamentary Sketch, Raymond Keene, Catherine Cracknell, Peter Riddell Political Briefing, Matt Dickinson, Elizabeth Hinks, Christine Buckley Industrial Editor, Greg Hurst and Richard Ford Home Correspondent, Robin Ash, Pauline Brooks, Bill Brandt, Jeremy Page, Clifford Coonan, Chris Campling, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Damian Whitworth, Anatole Kaletsky Economic View, David Mattin, Peter Dixon, Nick Hasell, Grania Langdon-Down, Nick Kelly, David Hands Rugby Correspondent, Tom Dart, Adam Fresco, Nell Harman Tennis Correspondent, James Bone and Daniel McGrory, Giles Whittell, Philip Webster Political Editor, Danny Lee, Christopher Walker, D. J. B. Hill, Berkhamsted, Ian Johns, David Lister and Daniel McGrory, Hertfordhire, Russell Jenkins, Ingrid Mansell, Michael Gove, Richard Beeston, Richard Beeston Diplomatic Editor, David Charter Chief Political Correspondent, Jack Malvern Arts Reporter, Richard Miles, Gary Duncan Economics Correspondent, Martin Waller, Mark Henderson, Chris Ayres, Michael Horsnell, Nigel Hawkes Science Editor, Carl Mortished International Business Editor, Alan Coren, Laura Peek, Nigel Hawkes Health Editor, Benedict Nightingale, Antony Peattie, E. G. Nugee, Stephen Dalton, Ian Rosenblatt, Philip Webster and Tony Halpin, Bill Edgar, Frances Gibb, Joseph Pestell, Valerie Grove, Alan Lee Racing Correspondent, Jenny Davey, Raymond Lipton, Anthony Speaight, Richard Ford, Patience Wheatcroft,
... with other Times readers The Spanish Elections Is Jose Luis Rodriguez Zapatero's appointment really'a victory for ...
2004 - Gale Group | TDA
Luis Eduardo López-Cortés, Mercedes Delgado-Valverde, Elisa Moreno-Mellado, Josune Goikoetxea Aguirre, Laura Guío Carrión, María José Blanco Vidal, Leyre Mónica López Soria, Pérez Rodríguez, Lucía Martínez Lamas, Francisco Arnaíz de las Revillas, Carlos Armiñanzas, Carlos Ruiz de Alegría Puig, Patricia Jiménez Aguilar, María del Carmen Martínez-Rubio, Carmen Sáez-Béjar, Carmen de las Cuevas, Andrés Martín-Aspas, Fátima Galán‐Sánchez, José Ramón Yuste, José Leiva, Germán Bou, Patricia Capón González, Lucía Boix-Palop, Mariona Xercavins-Valls, Miguel Ángel Goenaga-Sánchez, Diego Vicente Anza, Juan José Castón, Manuel Recio, Esperanza Merino, Juan Carlos Rodrı́guez, Belén Loeches, Guillermo Cuervo, María José Guerra Palmero, Antonio Plata, Salvador Pérez Cortés, Pablo López Mato, José Luis Sierra Monzón, Clara Rosso-Fernández, José María Bravo-Ferrer, Pilar Retamar, Jesús Rodríguez‐Baño, Marina de Cueto, Irene Borreguero, Javier Nieto Aranda, Adrián Sousa Domínguez, Claudia González-Rico, María Carmen Fariñas, María Luisa Fernández Ávila, Alberto Romero-Palacios, Francisca María Guerrero Sánchez, Marta Rúa Gómez, Idoia Bilbao del Olmo, Esther Calbo, Beatriz Dietl, Maialen Ibarguren Pinilla, Marta Gómez-Ruiz de Arbulo, Isabel Torres Beceiro, Isabel Machuca, Ángela Cano, Livia Giner, Héctor Pinargote Celorio, Emilio Cendejas‐Bueno, María Pilar Romero‐Gómez, Adrián Argüelles Curto, José María Reguero, M. Díaz-López, José Ramón Paño,
Background De-escalation from broad-spectrum to narrow-spectrum antibiotics is considered an important measure to reduce the selective pressure of antibiotics, but a scarcity of adequate evidence is a barrier to its implementation. We aimed to determine whether de-escalation from an antipseudomonal β-lactam to a narrower-spectrum drug was non-inferior to continuing the antipseudomonal drug in patients with Enterobacterales bacteraemia. Methods An open-label, pragmatic, randomised trial was performed ...
Tópico(s): Antibiotic Resistance in Bacteria
2024 - Elsevier BV | The Lancet Infectious Diseases
Waldemar Januszczak, Kathryn O'Sullivan, David Mills, Sally Brock, V S, Dave Garnett, Joe Gonzalez, Professor Gideon Garter, Amanda Ursell, Professor Iain Moffat, Dominic O'Conneil, Alastair McCall, Neil Wormald, Benoit Pensivy, Peter Hepper, Dominic Bradbury, Susan Berger, Martin James, Jonathan Ungoed-Thomas, Russell Watson, Rosie Millard, Ian Crithley, David Hewson, Hugh Canning, Sarah Dempster, Peter Kellner, Peter Oliver, Holly Watt, Paul Gostick, Nicholas Hellen, Caroline Scott, Shelley Von Strunckel, Christopher Morgan, Brian Jackman, Janet Daley, Frank Field MP, Robbie Hudson, Michalene Wandor, Emma Smith, Richard Tang, Uzi Mahnaimi, S A, Bryan Appleyard, John Elliott, Maurice Chittenden, Richard Brooks Arts Editor, Martin Corry, Brendan Simms, Dan Box, Chris Haslam, John Carey, Mary Braid, Nick Fielding, Mark Kleinmen, Liam Clarke, Peter Schmeichel, Graham Norwood, David Budworth, William Lewis Business editor, Lewis Moody, Clive Hetherington, Stewart Mitchell, Neil Hanson, Sarah Baxter, Jason Dawe, Jonathan Northcroft, Gianfranco Zola, Hala Jaber, Bagshawe, John Smith, Mark C O'Flaherty, Jim Munro, Peter Whittle, D M, Colin Brennan, Andrew Longmore, Lesley White, Robert Slater, Peter Whittie, Lynda Bellingham, Terence Blacker, Lucy Hughes-Hallett, E P, Andrew Sullivan, Patricia Hewitt, John Hariow, Beth Rogers, Stuart Barnes, Peter Jones, Cally Law, Mark Edward, Victoria Segal, Gareth Chadwick, Edward Porter, Phil Spencer, Dave Pollard, Martin Rees, Pam Barren, Joe Loveiay, Jeff Potter, Waldemar Januszcrak, Pat Malone, Brendan Bourne, Christopher Silvester, Stuart Wavell, Paul Donovan, Zoe Thomas, Hugh McIlvanney, Steve Boyd, Jennifer Wilson, Angela Young, John Follain, Louise, Ben Tomkins, Stuart Andrews, David Leppard, Kim Cattrall, John Dugdals, Chris White, Douglas Dalby, Lois Rogers, Alan Combes, Eddle Pitman, David Cracknell, Jayesh Ghaghda, David Walton, Diana Wright, Peter Koenig, Barry Flatman, Natalie Graham, Jessica Brinton, David Walsh, Spindale, Sarah Keenlyside, Stephen Armstrong, Mark Macaskill, Bethan Cole, Richard Woods, James Meller, Ray Hutton, Martin Ivens, Ria Higgins, Dileep Premachandran, A A Gill, Brian Glanville, Jeremy Langmead, Daniel Emery, Nigel Powell, Roger Dobson, Chris Whyatt, Ben Dowell, John Aizlewood, Jeremy Lazell, Lois Rogers Medical Editor, Jonathan Futrell, Hugh Pearman, Tony Perrottet, Ross Tieman, Annobel Nielsen, Rachel De Thame, Sylvia Ann Hewlett, Victora Segal, Richard Lewis, Helen Stewart, Kevin Dunn, John Dugdale, William Kay, Barbara Hall, Jon Swain, Rob Hughes, John Peter, Donna Leon, Ralf Schumacher, Blowere, Kevin Platt, Marian Donlan, Ivo Tennant, David Smith, Tim Richards, Adelheid Gowrie, Henry Russell, Adrian Furnham, Nicholas Hellen Social Affairs Editor, Malcolm Chapman, Stewart Lee, Peter Conradi, Ronne Corbett, Michael Portillo, Alfred Kinsey, Richard Fletcher, Jeremy Guscott, Dan Drillsma-Milgrom, Maggie Gee, Sarah-Kate Templeton, Paul Kimmage, Chris Woodhead, Alex Clark, Mark Edwards, Rachel Bridge, Susan Clark, Nick Rodrigues, Sean Newsom, Raymond Keene, Zoe Brennan, Kipper Williams, Stephen Jones, Robert Rutledge, Jemima Khan, Louise Armitstead, Brian Deer, Nick Cain, Tim Moorey, S Silvers, Victoria Raymond, Victoria O'brien, Roland White, David Waim, Richard Rae, Mark Franchetti, Michael Sheridan, Tevor Lewis, Dipesh Gadher, John Waples, Hunter Davies, David Horspool, Stephen Pettitt, Karen MacGregor, Mark Hodson, Simon Kurs, Andrew Frankel, Joe Lovejoy, Dan Cairns, David Smith Economics Editor, Hugh Mason, Karen Robinson, Helena Frith Powell, Helen Davies, Kenny Farquharson, Christopher Somerville, Sandra Owen, Frank Whitford, Sybil Kapoor, Andrew Taylor, P D, Melanie Rickey, Tom Burkard, Martin Brundle, Simon Wilde, Irwin Stelzer, Peter Wilson, Simon Woodroffe, David Dougill, Captain Walter Eggert, Frank Graham, Bob Barbour, Jonathon Carr-Brown, Paul Forsyth, Simon Gray, Geraldine Hackett Education Correspondent, Jeremy Clarkson, David Cairns, Greg Struthers, Colin Marett, Christian Allen Purefoy, George Perry, Christopher Lamb, Paul Ham, Fiona Fleck, Frances Spalding, Roger Schofield, Jasper Gerard, Paul Driver, Chris West, Tilly, Ian Hawkey, Paul Durman, Askold Krushelnycky, Rod Liddle, Cosmo Landesman, Sharon Ridoynauth, Mark Lister, Dominic O'Connell, Andrew Holgate, Roger Cryer, Andrew Smith, Jerome Carroll, Caroline Donald, Annette Karmiloff-Smith, Colin McDowell, Christopher Goodwin, Shane Watson, Eric Carlin, Cllve Davis, Clare Francis, John Harlow, Joel Stewart, Mark Kleinman, Peter Jonson, Jessica Bown, Sally Kinnes, Naomi Caine, David Wickers, Colin Russell, Julian Nettlefold, Jean-Paul Flintoff, Andrew Davidson, Richard Caseby, Janie Omorogbe, Matthew Goodman, India Knight, Kingston Smith, Arton Davies, Kay Sharp,
... Kenteris and Katerina Thanou Book of the week Jose Mourinho, Made in Portugal By Luis, Lourenco, DL Media Ltd. £12.99 Ian Woodsnam ...
2005 - Gale Group | Sunday Times HA GDA
María Chaparro, Ana Garre, Andrea Núñez Ortiz, M T Diz-Lois Palomares, Cristina Rodríguez, Sabino Riestra, Milagros Vela, J M Benítez, Estela Fernández Salgado, Eugenia Sánchez Rodríguez, Vicent Hernández, R Ferreiro-Iglesias, Ángel Ponferrada Díaz, Jesús Barrio, José María Huguet, Beatriz Sicilia, María Dolores Martín‐Arranz, Xavier Calvet, Daniel Ginard, Inmaculada Alonso-Abreu, Luis Fernández‐Salazar, Pilar Varela Trastoy, Montserrat Rivero, Isabel Vera‐Mendoza, Pablo Vega, Pablo Navarro, Mónica Sierra, José Luis Cabriada, Mariam Aguas, Raquel Vicente, Mercè Navarro‐Llavat, Ana Echarri, Fernando Gomollón, Elena Guerra del Río, Concepción Piñero, María José Casanova, Kateřina Špičáková, Jone Ortiz de Zárate, Emilio Torrella Cortés, Ana Gutiérrez, Horacio Alonso‐Galán, Álvaro Hernández-Martínez, José Miguel Marrero, Rufo Lorente Poyatos, Margalida Calafat, Lidia Martí Romero, Pilar Robledo, Orencio Bosch, Nuria Jiménez, María Esteve, José María Duque, Ana Fuentes Coronel, Manuela Josefa Sampedro, Eva Sesé Abizanda, Belén Herreros Martínez, Liliana Pozzati, Hipólito Fernández Rosáenz, Belén Crespo Suarez, Pilar López Serrano, Alfredo J. Lucendo, Margarita Muñoz Vicente, Fernando Bermejo, José Ramírez Palanca, Margarita Menacho, Amalia Carmona, Raquel Camargo, Sandra Torrá Alsina, Nuria Maroto, Juan Nerín de la Puerta, Elena Castro, Ignacio Marín‐Jiménez, Belén Botella, Amparo Sapiña, Noelia Cruz, José Luis Fernández Forcelledo, Abdel Bouhmidi, Carlos Castańo-Milla, Verónica Opio, Isabel Nicolás, Marcos Kutz, A. Abraldes Bechiarelli, Jordi Gordillo, Yolanda Ber, Yolanda Torres Domínguez, M. Novella Durán, Silvia Rodríguez Mondéjar, Francisco J. Martínez-Cerezo, Lilyan Kolle, M Sàbat, César Ledezma, Eduardo Iyo, Óscar Roncero, Rebeca Irisarri, Laia Lluis, Isabel Blázquez Gómez, Eva Zapata, María José Fernández Alcalá, Cristina Martínez Pascual, María Montealegre, Laura Mata, Ana Monrobel, Alejandro Hernández-Camba, Luis Hernández, Marı́a Jesús Gómez de Tejada, Alberto Mir, María Luisa Galve, Marta Soler, Daniel Hervías, José Antonio Gómez-Valero, Manuel Barreiro–de Acosta, Fernando Rodríguez‐Artalejo, Esther García‐Esquinas, Javier P. Gisbert,
(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 ...
Tópico(s): Pregnancy and Medication Impact
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
FROM OUR SPECIAL CORRESPONDENT., FROM OUR NEWMARKET CORRESPONDENT., FROM OUR CRICKET CORRESPONDENT., From Our Special Correspondents., FROM OUR CORRESPONDENT., By CALLISTHENES., BY A MILITARY CORRESPONDENT., FROM A CORRESPONDENT., FROM OUR OWN CORRESPONDENT., FROM OUR CORRESPONDENT AT GENEVA., From Our Labour Correspondent., From Our Special Correspondent., G. W. HOLMES., J. A. R. MARRIOTT., L. P. WINBY., W. HOWARD HAZELL., C. H. P. MAYO., W. MOORE EDE., MURRAY F. SUETER., A MOTORIST OF MORE THAN August 8. 500, 000 MILES., J. A. GIBB., FROM OUR CHESS CORRESPONDENT., A correspondent, From Our Madrid Correspondent., By JOSÉ MARIA GONZALEZ., By R. Ruiz Ferry., FROM A CORRESPONDENT IN SEVILLE., By RAMON HERNANDEZ MATEOS, From a Spanish Correspondent., By JOSÉ CALVO SOTELO, BY OUR OWN CORRESPONDENT., By J. H. PERRY., By L. E. ELLIOTT., By AUBREY F. G. BELL., FROM A CORRESPONDENT IN SPAIN., By SEVERIANO VEGA DE SEOANE, BY CARLOS MENDOZA., By H. T. CORY, By CARLOS POSADA., By Professor R. CARANDE, By JULIO LOPEZ OLIVAN., By THE DUKE OF ALBA., By W. G. CASS., By Brig.-General G. V. CLARKE., FROM OUR MADRID CORRESPONDENT., By E. CUNARD., By F. MARTÍN-SANCHEZ JULIÁ., By LUIS GARCIA GUIJARRO., By MARCELINO DE ARANA, By JOSÉ CASTILLEJO., By F. RESTREPO, S.J., By "BEATRIZ GALINDO.", By RAMIRO DE MAEZTU., By J. B. TREND., By SIR CHARLES BEDFORD, By JOAQUIN DE ZUAZAGOITIA., By Dr. JOSÉ M. GIL ROBLES., By Professor ELIAS TORMO, By MILDRED STAPLEY BYNE., By Professor L. JORDANA., By the MARQUIS MERRY DEL VAL., By ADOLFO POSADA., De nuestro corresponsal en Madrid., DE UN CORRESPONSAL., Por DON JOSÉ MARIA GONZALEZ, Por DON RICARDO RUÍZ FERRY., DE UN CORRESPONSAL EN SEVILLA., POR UN CORRESPONSAL., Por DON RAMÓN HERNÁNDEZ MATEOS, Ingeniero Civil., De un Corresponsal Español., Por Don JOSÉ CALVO SOTELO., DE NUESTRO CORRESPONSAL., Por J. H. PERRY., Por L. E. ELLIOTT., Por AUBREY F. G. BELL., DE UN CORRESPONSAL EN ESPAÑA., Por DON SEVERIANO VEGA DE SEOANE, Ingeniero de Minas., Por DON CARLOS MENDOZA, Por H. T. CORY, Por DON CARLOS POSADA., Por el Profesor R. CARANDE., Por DON JULIO LÓPEZ OLIVÁN, , Por el DUQUE DE ALBA., Por W. G. CASS., Por el GENERAL G. V. CLARKE, DE NUESTRO CORRESPONSAL EN MADRID., Por E. CUNARD., Por DON F. MARTÍN SANCHEZ JULIÁ, Ingeniero Agronomo., Por DON LUIS GARCÍA GUIJARRO., Por DON MARCELINO ARANA., Por DON LUIS GARCIA GUIJARRO., Por DON JOSÉ CASTILLEJO., Por el PADRE F. RESTREPO., Por, , BEATRIZ GALINDO.", Por DON RAMIRO DE MAEZTU., Por J. B. TREND., Por SIR CHARLES BEDFORD, Por DON JOAQUÍN DE ZUAZAGOITIA., Por DON JOSÉ M. GIL DE ROBLES, Por DON ELLAS TORMO, Por MILDRED STAPLEY BYNE., Por el Profesor L. JORDANA, Por el MARQUÉS DE MERRY DEL VAL., Por, , BEATRIZ GALINDO.", Por DON ADOLFO POSADA.,
Births. Marriages. Deaths. Classified Advertising: Transfer Books., Road Transport., London Hotels, Domestic Situations Vacant, Entertainments Index., ...
1926 - Gale Group | TDA
Jesús Ramón-Sierra, José Luis Martínez-Guevara, Luis Pool-Yam, Denis Magaña-Ortíz, Alejandro Yam-Puc, Elizabeth Ortíz‐Vázquez,
Antimicrobial effects of Melipona beecheii honey have been attributed to diverse factors, in this sense, certain components such as proteins and phenolics could explain relevant aspects of its antimicrobial activity. The aim of this study was to evaluate the antibacterial activity of phenolic and protein extracts from M. beecheii honey against two bacterial pathogens: Staphylococcus aureus and Escherichia coli. With respect to phenolic content, HPLC analysis allowed the identification of phenolic ...
Tópico(s): Essential Oils and Antimicrobial Activity
2020 - Springer Science+Business Media | Food Science and Biotechnology
By Barrie Clement and Clifford Webb, By Barrie Clement, Labour Reporter, By Christopher Warman Arts Correspondent, By John Winder, By Stewart Tendler, By David Hewson, From Robert Fisk, Beirut, By John Lawless, By Nicholas Timmins, From Harry Golombek, Chess Correspondent, By Bill Johnstone Electronics Correspondent, By Clive Cookson Technology Correspondent, By Peter Evans, Home Affairs Correspondent, From Arthur Osman, By David Walker, Local Government Correspondent, By Our Parliamentary Staff, From Richard Ford, Enniskerry, co Wicklow, From Our Correspondent, By Richard Dowden, By Stephen Goodwin, By Kennth Gosling, By Hugh Clayton, Environment Correspondent, By a Staff Reporter, From John Carlin, Mexico City, From Philip Taubman (NYT), Washington, From Richard Owen, Moscow, From Robert Schuil on board MS Stad Zierikzee, From Our Own Correspondent, Rome, From Christopher Walker, From Michael Hamlyn, Delhi, From Ray Kennedy, Johannesburg, By Rodney Cowton, From Richard Hughes, , From Harry Debelius, Pat Healy Social Services correspondent, Dr Thomas Stuttaford, PHS, Windsor Chorlton, George Walden, Philip Howard, ERIC MCGRAW, Director, , DAVID HOBMAN (Age Concern, , JOHN HUNTINGTON (Health, SALLY GREENGROSS, KEITH THOMPSON, , N. HOWARD, , NIGEL WEST, E. J. LIPSCOMBE, , ROSALIE DIGBY-SEYMOUR, , PETER CAMPBELL, , I. D. WATSON, , JAMES BOOTH, , MARJORIE JONES, , W. M. T. MAGAN, , D. C. BARRETT, , JOHN OFFEN, , R. ROBSON, , By Charles McKean, By Clifford Longley, Religious Affairs Correspondent, By Bill Johnstone, Electronics Correspondent, Geoff Brown, Hilary Finch, Michael Church, Anthony Masters, City Editor Anthony Hilton, By Our Financial Staff, By Peter Wilson-Smith, Banking Correspondent, By Wayne Lintott, By Jonathan Davis, Financial Correspondent, By Our Finance Staff, By David Young Energy Correspondent, By Our Energy Correspondent, edited by Michael Prest, By Our Industrial Correspondent, From Martha de la Cal, Lisbon, By Jonathan Clare, By John Woodcock, Cricket Correspondent, By Peter Ball, By Alan Gibson, By Richard Streeton, By Alan Ross, By Michael Phillips, Racing Correspondent, By Michael Phillips, From Lewine Mair, Dublin, By John Nicholls, By Gordon Allan, By John Blunsden, By John Watson, From David Miller, Helsinki, From Pat Butcher, From Nicholas Harling, From Ivor Davis Las Vegas, Edited by Peter Davalle, John Witherow,
... in society for young and old, Soviet 'moles', Luis Buñuel, Not cricket. Court and Social: Court Circular. Marriages. Births. Picture Gallery. Deaths. Obituaries: Obituary, Clytie Hine Mundy, Admiral Jose Pinheiro De Azevedo Leading role in Portugal's ...
1983 - Gale Group | TDA
Alejandro de la Sierra, José Luis Zamorano, Luís M. Ruilope,
Clinical practice guidelines on the management of hypertension such as the 2007 European Society of Hypertension (ESH)/European Society of Cardiology (ESC) Guidelines were developed with the objective of allowing a greater number of patients with high blood pressure to be detected and effectively treated. The acceptance of hypertension guidelines and their implementation in clinical practice by ‘front-line’ physicians continues to be less than optimal for a variety of reasons, however, including the ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2009 - Lippincott Williams & Wilkins | Journal of Hypertension
Jon Infante, Inés García‐Gorostiaga, Pascual Sánchez‐Juan, María Sierra, José Luis Martín-Gurpegui, José Henrique Imaca Terrazas, Ignacio Mateo, Eloy Rodríguez‐Rodríguez, José Berciano, Onofre Combarros,
Oxidative stress is a central factor in the pathogenesis of Parkinson's disease (PD). Heme oxygenase-1 (HO-1) is an antioxidant protein expressed in response to oxidative challenge, and its expression levels are inversely correlated with glycogen synthase kinase-3beta (GSK3beta) activity. Underexpression of HO-1 in concert with an upregulation of GSK3beta would result in a less effective antioxidant response and might increase the risk of PD.We examined two functional polymorphism in the promoter regions ...
Tópico(s): Cannabis and Cannabinoid Research
2009 - Wiley | European Journal of Neurology
C. Leizaola–Fernández, L. Suarez-Tata, Hugo Quiroz-Mercado, L. Colina, Jans Fromow-Guerra, Juan Manuel Jiménez-Sierra, José Luis Guerrero-Naranjo, Virgilio Morales-Cantón,
Abstract Background Central retinal vein occlusion (CRVO) is a common retinal vascular disorder with potentially complications: (1) persistent macular edema and (2) neovascular glaucoma. No safe treatment exists that promotes the return of lost vision. Eyes with CRVO may be predisposed to vitreous degeneration. It has been suggested that if the vitreous remains attached to the macula owing to a firm vitreomacular adhesion, the resultant vitreous traction can cause inflammation with retinal capillary ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2005 - BioMed Central | BMC Ophthalmology
Isabel Sierra, José Luis Valera, Marı́a Luisa Marina, F. Laborda,
We have isolated and characterised a novel aerobic bacterial strain, designated MS3-02, belonging to the genus Janibacter sp. The capability of this new strain to degrade polychlorinated biphenyls (PCBs) in a commercial mixture (Aroclor 1242) in liquid medium and in soil (sterile and non sterile soil), under laboratory scale, has been evaluated. MS3-02 was isolated from the soil around of an incinerator, located in the east of Madrid (Spain). Gas-chromatographic analysis showed that MS3-02 was able ...
Tópico(s): Microbial Community Ecology and Physiology
2003 - Elsevier BV | Chemosphere
Iván Razmilic, Jorge Román‐Sierra, José Luis López‐Pérez, Manuel Cortés,
Abstract A short synthesis of (−)-Warburganal, from (+)-confertifoline through the α-epoxide is described.
Tópico(s): Synthesis of Organic Compounds
1985 - Oxford University Press | Chemistry Letters
Marcela Garzón-Tituaña, Maykel Arias, José Luis Sierra-Monzón, Elena Morte-Romea, Llipsy Santiago, Ariel Ramírez-Labrada, Luis Martínez‐Lostao, José Ramón Paño‐Pardo, Eva M. Gálvez, Julián Pardo,
Sepsis is a serious global health problem. In addition to a high incidence, this syndrome has a high mortality and is responsible for huge health expenditure. The pathophysiology of sepsis is very complex and it is not well understood yet. However, it is widely accepted that the initial phase of sepsis is characterised by a hyperinflammatory response while the late phase is characterised by immunosuppression and immune anergy, increasing the risk of secondary infections. Granzymes (Gzms) are a family ...
Tópico(s): Complement system in diseases
2020 - Frontiers Media | Frontiers in Immunology
Alejandro Rodríguez, Francesc Xavier Avilés‐Jurado, Emili Dı́az, Philipp Schüetz, Sandra Trefler, Jordi Solé‐Violán, Lourdes Cordero, Loreto Vidaur, Ángel Estella, Juan Carlos Pozo Laderas, Lorenzo Socías, Juan Carlos Vergara, Rafael Zaragoza, Juan Bonastre, J.E. Guerrero, Borja Suberviola, Catia Cillóniz, Marcos I. Restrepo, Ignacio Martín‐Loeches, Pedro Cobo, Javier Martins, Cecilia Carbayo, Emilio Robles‐Musso, Antonio Cárdenas, J.M. Garrido Fierro, Dolores Ocaña Fernández, Rafael Sierra, Ma Jesús Huertos, Ma Luz Carmona Pérez, Juan Carlos Pozo Laderas, R. Guerrero, Juan Carlos Robles, Melissa Echevarría León, Alberto Gómez, Enrique Márquez, Manuel Rodríguez-Carvajal, Ángel Estella, José Pomares, José Ballesteros, O Moreno Romero, Yolanda Fernández, Francisco Carlos Faria Lobato, J Prieto, José Albofedo-Sánchez, Pilar Martínez, M. V. de la Torre, María Nieto, Estefanía Camara Sola, Miguel Ángel Díaz Castellanos, Guillermo Sevilla Soler, C. Ortiz Leyba, José Garnacho‐Montero, Rafael Hinojosa, E. M. Barreiro Fernandez, Ana Loza, Cristóbal León, Samuel González López, Ángel Arenzana, Dolores Ocaña, Inés Navarrete, M. Zaheri Beryanaki, I. Torres Sánchez, Manuel Pérez Alé, Ana Ma Poullet Brea, Juan Francisco Machado Casas, C. Serón Arbeloa, M.L. Avellanas, Arantxa Lander, Sanchez Arellano, M.I. Marquina Lacueva, Pilar Luqué, Elena Plumed Serrano, Juan Francisco Martín Lázaro, C. Sánchez Polo, Isabel Gutiérrez, Belén Jiménez Bartolomé, Carlos López Núñez, I. Alcantud González, José Ignacio Tomás Marsilla, Clara Jaques Andrés, Pablo Gtiérrez Ibañes, Pilar Araujo Aguilar, J. M. a. Monton, Paloma Dorado Regil, Lisardo Iglesias, Carmen Pascual González, Brígida Quindós Fernández, Lorena Martín Iglesias, Lucía Viña Soria, Raquel Yano Escudero, Ma del Rosario Mtnez Revuelta, Quiroga, Águeda García-Rodríguez, Marta Cuadrado, Ana Luz Balán Mariño, Lorenzo Socías, Pedro Ibañez, Marcio Borges-Sá, Antònia Socías, Alberto del Castillo, R. Jordà Marcos, Cristina Muñoz, José M. Bonell, Ignacio Amestarán, M. Angeles González López, Cecília Vilanova Pàmies, José Ma. Bonell Goytisolo, José Antonio Morales Carbonero, José Ma. Bonell Goytisolo, José Antonio Morales Carbonero, Rossana Pérez Senoff, Marta Generelo López de Medrano, Sergio Ruiz‐Santana, Juan José Díaz, Catalina Sánchez Ramírez, Montse Sisón, David Hernández, Ana Aragón Trujillo, Luis E. Regalado, Sonia Rodríguez Fndez, Leonardo Lorente, Judith Cabrera Rivero, María Luisa Mora Quintero, Mar Martín, Sergio Lopez Martinez, Juan J. Cáceres, Manuel Sanchez Palacio, Marcos Marcos, D. García Rodríguez, María Ripoll Leria, Borja Suberviola, Pablo Ugarte, Fernando García López, Rafael Sánchez Iniesta, Angel A. Alonso, Antonio Trugeda Padilla, Basi Martínez Palacios, M Grande, Ma. Carmen Martín Rodríguez, Hasania Adbel-Hadi Álvarez, A. Ambrós Checa, Higinio Martín Hernández, Antonio Albaya, Alberto Silva Obregón, Carlos Marian Crespo, Carlos Armendariz Estrella, Carmen Benito Puncel, Eduardo Quirós Oyargue, Alfonso Canabal Berlanga, Luis María Marina, Ismael López de Toro, Almudena Simón, José María Añón, Juan B. López Messa, Ma Jesús Pueyo, Ortíz María del valle Sergio Ossa Echeverri, Z. Ferreras, Juan Carlos Ballesteros Herráez, Santiago Macías, José Ángel Berezo, Jesús Blanco Varela, Pablo Blanco Schweizer, A González Salamanca, Luis Tamayo Lomas, Andaluz Ojeda Anzález, Ramón Cicuéndez Avila, Pérez G. Francisco Javier, Antonio Álvarez Terrero, Fabiola Tena Ezpeleta, Christian Sala, Oliverio López, Zulema Paez, Álvaro García, Demetrio Carriedo, Miriam Riesco Crespo, Jesús Pino Rebolledo, Nicolás Hidalgo Andrés, Ana Carolina Caballero Zirena, Belén Román García, Juan B. López Messa, María del Valle Ortíz, Sergio Ossa Echeverri, Rosa Catalan, Miquel Ferrer, Antoni Torres, Catia Cillóniz, Sandra Barbadillo Ansorregui, Lluís Cabré, Ignacio Baeza, A Rovira, Francisco Álvarez-Lerma, Antònia Vázquez, J. Nolla, F. FERNÁNDEZ, Joaquim Ramon Cervelló, Raquel Iglesia, Rafael Máñez, J. Ballús, Rosa Granada, Jordi Vallès, Emili Dı́az, Marta Ortíz, C. Guía, Ignacio Martín‐Loeches, Joaquim Páez, Jordi Almirall, Xavier Balanzó, Estel Güell, Juan Carlos Yébenes, Jordi Rello, Elena Arnau, Marcos Pérez-Carrasco, César Laborda, Jesica Souto, Leonel Lagunes, Iñaki Catalán, J.M. Sirvent, Nerea López de Arbina, Anna Baró Serra, Adriana Sánchez, Silvia Cuenca, Mariona Badía, Begonia Baseda-Garrido, Montserrat Valverdú-Vidal, Fernando Barroso-Barcenilla, Mercedes Palomar, Xavier Nuvials, Pedro Garrido Benedicto, Ferran Roche Campo, Mercedes Esteban, J. Luna, Gaspar Eixarch, Angels Pascual Diago, J. M. a. Nava, Francisco Molina, Josep Trenado, Ricard Ferrer, Zoran Josic, Montserrat Casanovas, Francisco Gurri, Paula Nicole Viteri Rodriguez, Alejandro Rodríguez, Laura Claverías, Sandra Trefler, María Bodí, Mònica Magret, C. Ferri, Rosa Díaz, Eduard Mesalles, Fernándo Arméstar, Diego de Mendoza, Carmen Lomas Fernández, José Julián Berrade, Alfonso Bonet Saris, Marina Pechkova, Cristina Mora Jiménez, Santiago Gil, Jose Antonio Juliá-Narvaéz, Manuel Robles Marcos, Vanessa Farje Mallqui, M Triviño, Pablo García, Alberto Fernández-Zapata, Teresa Recio, Abilio Arrascaeta, Ma José García-Ramos, Elena Gallego, Esther Saiz Rodrigo, F. Romero Bueno, Mercedes Robles Diaz, Noemí Gil Pérez, David López Hormigo, Juan Diego Jiménez Delgado, Pérez Frutos, Martina Pinna, Ma Lourdes Cordero, José A. Pastor, Luis Álvarez-Rocha, Alexandra Ceniceros Barros, Alejandra Virgós Pedreira, D. Vila, Carmen Fernández González, J Perez-Serrano, M. Ortiz Piquer, Eleuterio Merayo, Victor Jose López-Ciudad, Juan Cortes Cañones, Eva Vilaboy, José Villar Chao, Francisco Savira Cid López, Pablo Vidal, Marcos A. Pérez Veloso, Eva Maria Saborido, Enrique Alemparte Pardavila, Ana Ortega Montes, Raul José González,
To define which variables upon ICU admission could be related to the presence of coinfection using CHAID (Chi-squared Automatic Interaction Detection) analysis.A secondary analysis from a prospective, multicentre, observational study (2009-2014) in ICU patients with confirmed A(H1N1)pdm09 infection. We assessed the potential of biomarkers and clinical variables upon admission to the ICU for coinfection diagnosis using CHAID analysis. Performance of cut-off points obtained was determined on the basis ...
Elsevier BV
Eduardo Miguel Sierra, José Luis Ordóñez-Ávila,
Owing to their compliance with most shapes, soft actuators are regarded as cost-effective solutions for grasping irregular objects. The material properties of nonlinear elastic polymers are considered necessary for the correct implementation of these actuators. The analysis tends to be complex even for simple movements defined by theoretically infinite degrees of freedom. This study offers a mathematical model that outlines a relationship between the energy provided by a pressure source and the ...
Tópico(s): Innovations in Concrete and Construction Materials
2022 - Multidisciplinary Digital Publishing Institute | Actuators
Iratxe Uranga-Murillo, Elena Morte, Sandra Hidalgo, Cecilia Pesini, Sandra García‐Mulero, José Luis Sierra-Monzón, Llipsy Santiago, Maykel Arias, Diego de Miguel, María del Mar Encabo-Berzosa, Borja Gracia-Tello, Rebeca Sanz‐Pamplona, Luis Martínez‐Lostao, Eva M. Gálvez, José Ramón Paño‐Pardo, Ariel Ramírez-Labrada, Julián Pardo,
Coronavirus disease 2019 (COVID19), caused by SARS-CoV-2, is a complex disease, with a variety of clinical manifestations ranging from asymptomatic infection or mild cold-like symptoms to more severe cases requiring hospitalization and critical care.The most severe presentations seem to be related with a delayed, deregulated immune response leading to exacerbated inflammation and organ damage with close similarities to sepsis.Methods: In order to improve the understanding on the relation between ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Ivyspring International Publisher | Theranostics
Alejandro Rodríguez, Emili Dı́az, Ignacio Martín‐Loeches, Alberto Sandiumenge, Laura Canadell, Juan José Díaz, Juan Carlos Figueira, A. Fe Marqués, Francisco Álvarez-Lerma, Jordi Vallès, B. Baladin, Fernando García López, Borja Suberviola, Rafael Zaragoza, Sandra Trefler, Julia Bonastre, José Blanquer, Jordi Rello, Pedro Cobo, João Martins, Cecilia Carbayo, Emilio Robles‐Musso, A. Cárdenas, Julie L. Fierro, Dolores Ocaña Fernández, Rafael Sierra, Miguel A. Huertos, Juan Carlos Pozo, R. Guerrero, Enrique Márquez, Manuel Rodríguez-Carvajal, Antonio Jareño, José Diego Quiles Pomares, José Luis Ballesteros Rodríguez, Yolanda Fernández, F. Lobato, Judith Prieto, José Albofedo-Sánchez, Pablo Pérez‐Martínez, Moreno Castellanos, Guillermo García-Pérez-de-Sevilla, José Garnacho‐Montero, R. Hinojosa, E. Fernández, Ana Loza, Carlos F. Mendes de Leon, Ángel Arenzana, Dolores Ocaña, Inés Navarrete, M. Zaheri Beryanaki, I. Sanchez, M.L. Avellanas, A. Lander, Sanchez Arellano, M.I. Marquina Lacueva, Pilar Luqué, Isabel del Bosque González, J. M. a. Monton, Paloma Dorado Regil, Lorena Martín Iglesias, Carmen Pascual González, Quiroga, Antonio García‐Rodríguez, Lorenzo Socías, Pablo Ibáñez, Marcio Borges-Sá, Antònia Socías, Alberto del Castillo, R. Jordà Marcos, José M. Bonell, Ignacio Amestarán, Sergio Ruiz‐Santana, Juan José Díaz, Sison, David Hernández, Antonio Trujillo, Luis E. Regalado, Leonardo Lorente, María José Martín Alonso, Sofía Martínez, Juan J. Cáceres, Borja Suberviola, Pablo Ugarte, Fernando García López, Angel A. Alonso, A. Pasilla, M Grande, Antonio Albaya, Alfonso Canabal Berlanga, Luis María Marina, Arne Simon, José María Añón, Juan B. López Messa, M. a. J. Lopez Pueyo, Z. Ferreras, S. Macías, José Ángel Berezo, Jesús Blanco Varela, Agustina A. Ojeda, Alexis Terrero, Fabiola Tena Ezpeleta, Zulema Paez, Álvaro García, Rosa Catalan, Miquel Ferrer, Antoní Torres, S. Barbadillo, Lluís Cabré, A Rovira, Francisco Álvarez-Lerma, A Domínguez Vázquez, J. Nolla, F. FERNÁNDEZ, Joaquim Ramon Cervelló, Rafael Máñez, J. Ballús, Rosa Granada, Jordi Vallès, María del Valle Ortíz, C. Guía, Fernándo Arméstar, J Páez, Jordi Almirall, Xavier Balanzó, Jordi Rello, Empar Sainz Arnau, Leonor Cuadra-Llopart, Mercedes Palomar, I. Catalán, J.M. Sirvent, C. Ferri, Nerea López de Arbina, Mariona Badía, Montserrat Valverdú-Vidal, Fernando Barroso-Barcenilla, Mònica Magret, Mercedes Esteban, J. Luna, J. M. a. Nava, Francisco Molina, Zoran Josic, Francisco Gurri, Alejandro Rodríguez, Thiago Lisboa, Diego de Mendoza, Sandra Trefler, Rosa María Díaz, Eduard Mesalles, J.-N. Jose, Alberto Fernández-Zapata, Tomás Recio, Abilio Arrascaeta, M. a. J. Garcia-Ramos, Elena Gallego, Flávia Umpierre Bueno, Manuel Quintana‐Díaz, M. a. L. Cordero, Javier Pastor, Luis Álvarez-Rocha, D. Vila, Alejandro Lamas, J Perez-Serrano, M. Ortiz Piquer, Eleuterio Merayo, Victor Jose López-Ciudad, José Alberto Aguilar Cortez, Eva Vilaboy, Eva Maria Saborido, Richard J. Gonzalez, Santiago Freita, Argüello López, Juan Canabal, Enrique Ferres, José Luis Sierra Monzón, Félix M. Goñi, F. del Nogal Sáez, M. Blasco Navalpotro, M. a. C. Garcia-Torrejon, César Pérez–Calvo, David Lopez, Luis Arnaiz, Salvador Sánchez‐Alonso, Carlos Velayos, F. del Río, Miguel Angel Guillén González, Carmen Martín, J.M. Molina, Juan Carlos Montejo, M. Catalán, Patricia Albert, A. de Pablo, J.E. Guerrero, Jaime Benitez Peyrat, E. Cerdá, Manuel Álvarez, Carlos Pey, María del Pilar Rodríguez, E. Palencia, Romina Caballero, Concepción Vaquero, Francisco Mariscal, Sandra G. García, Nieves Carrasco, I. Prieto, Aurora Lietor, Rosio Ramos, Beatriz Galván, Juan Carlos Figueira, Cruz Soriano, P. Galdós, Bárbara Balandín Moreno, Fernández del Cabo, C. Hermosa, Federico Gordo, A. Algora, Antonio Paredes, J. A. Cambronero, Sonia Gómez-Rosado, Luis Miguel Prado López, Sofía Martínez, F. Felices Abad, María Martínez, Sergio Manuel Butí, Bernardo Gil Rueda, Fernanda Berenice Ramírez García, Laura Macaya, E. Maraví-Poma, I. Jiménez Urra, L. Macaya Redin, Ana Lucía Tellería, Josu Insansti, N. González, Pilar Marco, Loreto Vidaur, Beatriz Santamaría, J. C. Vergara, José Ramón Iruretagoyena Amiano, Alberto Blázquez Manzano, Carlos Castillo Arenal, Pedro Olaechea, José Blanquer, Roberto Reig Valero, A. Belenger, Susana Altaba, B. Álvarez-Sánchez, Santiago Alberto Picos, Ángel Sánchez-Miralles, Julia Bonastre, M. Palamo, José María Fernández Cebrián, José Cuñat, Belén Romero, Rafael Zaragoza, Virgilio Paricio, A. Fe Marqués, Silvia Sánchez-Morcillo, Sergi Tormo, Jos M. Latour, María Ángel García, A. S. Margarit,
ObjectivesThe impact of oseltamivir on mortality in critically ill patients with 2009 pandemic influenza A (2009 H1N1) is not clear. The main objective of this study was to investigate the relationship between the timing of antiviral administration and intensive care unit (ICU) outcomes.
Tópico(s): Pneumonia and Respiratory Infections
2011 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Jesús Rodríguez‐Baño, Jerónimo Pachón, Jordi Carratalà, Pablo Ryan, Inmaculada Jarrín, María Yllescas, José Ramón Arribas, Juan Berenguer, Esther Aznar Muñoz, Pedro Gil Divasson, Patricia González Muñiz, Clara Aguirre, Marta Díaz‐Menéndez, Fernando Calle, Marta Arsuaga Vicente, Elena Trigo Esteban, Ignacio Valero, Rosa de Miguel Buckley, Julen Cadiñanos, Beatriz Díaz‐Pollán, Luz Martín‐Carbonero, Juan Carlos Ramos Ramos, Belén Loeches Yagüe, Rocío Montejano, Juan González‐García, Julio García‐Rodríguez, Juan Berenguer, Margarita Ramírez, Isabel Gutiérrez, Francisco Tejerina, Teresa Aldámiz‐Echevarría, Cristina Díez, Chiara Fanciulli, Leire Pérez‐Latorre, Blanca Pinilla, Juan Carlos López, Ana Such Díaz, Elena Álvaro Alonso, Juan Torres Macho, Guillermo Cuevas, Eva Jiménez, Fátima Brañas Baztán, Jorge Valencia de la Rosa, Mario Pérez, Inés Fernández Jiménez, Gemma Muñiz Nicolás, Antonia Sepúlveda Berrocal, Alberto Gato Díez, María Pilar Toledano Sierra, María Paz García Butenegro, Ana Isabel Peláez Ballesta, Elena Morcillo Rodríguez, Isidoro Fernández Romero, Cristina Peláez Ballesta, María Isabel Guirado Torrecillas, Josune Goikoetxea, Elena Bereciartua Bastarrica, Laura Guío Carrión, Regino Rodríguez, Marta Ibarrola Hierro, Isabel Hernández, Inés Pérez Zapata, Sergio Román Soto, Mohamed Kallouchi, Juan Ramón Domínguez Vicent, Rafae Silvariño Fernández, Jon Ugalde Espiñeira, Ainhoa Sanjuan López, Silvia García Martínez, Mikel Temprano Gogenola, Víctor Asensi, Silvia Suárez, Lucia Suárez, Carmen Yllera, María Rivas-Carmenado, Alberto Romero-Palacios, Jesús Ruiz Aragón, Patricia Jiménez Aguilar, Ma Luisa Fernández Ávila, Rosario Castilla Ortiz, Vanesa Alende Castro, Cristina Pérez García, Marta Fernández Morales, María Lorena María Valle Feijoo Begoña Rodríguez Ferreira, Joan Gómez‐Junyent, Judit Villar-García, Inmaculada López-Montesinos, Itziar Arrieta‐Aldea, Abora Rial‐Villavecchia, Elisa García Vázquez, Aychel Elena Roura Piloto, Encarnación Moral Escudero, Alicia Hernández Torres, Helena Iglesias, David Vinuesa García, Clara Martínez Montes, Francisco Javier de la Hera Fernández, Francisco Anguita-Santos, Andrés Ruiz Sancho, Vicens Díaz-Brito, Montserrat Sanmartí, Sergio España Cueto, Daniel Molina Morant, Araceli González-Cuevas, Joel Elías Chara Cervantes, Guillem Policarpo Torres, Meritxell Ortega Montoliu, Mónica Nadal, Ariadna de Genover Gil, Eleni Patera, Rita Godoy Lorenzo, Evangelia Anna María Zioga, Virginia Isern Fernández, Carlos Enrique Sabbagh Fajardo, Ana Ferrer Ribera, Carlos Bea Serrano, R Sempere, Sara Vela, Paloma Albiol Viñals, Miguel Pedromingo Kus, María Ángeles Garcinuño, Silvana Fiorante, Sergio Pérez Pinto, Alexandra de la Vega, María Carmen Fariñas Álvarez, Claudia González-Rico, Francisco Arnaíz de las Revillas, Teresa Giménez, Jorge Calvo, Yolanda Meije Castillo, Alejandra Duarte Borges, Júlia Pareja Coca, Mercedes Clemente Presas, Xavier Salvador, Ma Teresa Pérez Rodríguez, Dolores Sousa, Alexandre Pérez‐González, Rebeca Longueira, Alejandro Araujo, Blanca Alonso Martínez, Laura García Escudero, Sara Lidia Kamel Rey, David Roa Alonso, Juan Pablo Avilés Parra, Iván Pelegrín Senent, Rosana Rouco Esteves Marques, L Raich Montiu, Jessica Souto Higueras, Manuel Alejandro Gálvez Bobadilla, Jorge Parra-Ruiz, Violeta Ramos-Sesma, Sara Velasco Fuentes, Laura García Pereña, Alfonso Lluna Carrascosa, Sergio Gilaberte Reyzábal, Mónica Liébana Gómez, Juan Salillas Hernando, Alberto Serrano Martínez, Miguel Torralba, Patricia Martínez, Isabel Rábago Lorite, Patricia González-Ruano Pérez, Beatriz Pérez-Monte Mínguez, Ángeles García Flores, Pere Comas Casanova, Andrea Martín Plata, S. Baez, O. Sanz, Karim Mohamed Ramírez, José Bordón, H.H. Vilchez Rueda, Melchor Riera Jaume, Gemma Mut Ramón, Meritxell Gavaldà Manso, Lluís Planas Bibiloni, Laura Castelo, Lucía Ramos Merino, Efrén Sánchez Vidal, María Rodríguez Mayo, Enrique Míguez Rey, José María García de Lomas Guerrero, Javier de la Torre, Ana Correa Ruiz, Fernando Fernández Sánchez, Nicolás Jiménez-García, José Luis Sierra-Monzón, Borja Gracia-Tello, María Hernández-Bonaga, G. Pellejero, Marta Asín-Corrochano, Lucía Boix Palop, Esther Calbo, Cristina Badía, Beatriz Dietl, Gómez Lucía, Ángel Domínguez-Castellano, Maria José Ríos-Villegas, María Dolores del Toro, Zaira R. Palacios‐Baena, Elena Salamanca-Rivera, Elena Marín‐Cascales, Virginia Almadana Pacheco, Salvador Pérez-Galera, Luisa González-Iglesias, Gabriela Abelenda-Alonso, Claudia Álvarez-Pouso, Francesc Escrihuela, Carlota Gudiol, Laia Lorenzo-Esteller, Jordí Niubó, Daniel Podzamczer, Miquel Pujol, Alexander Rombauts, Miguel Salvert Lletí, Ricardo Gil Sánchez, Marta Jiménez Escrig, Laura Parra Gómez, Mariona Tasias Pitarch, Marta Navarro Vilasaró, María Luisa Machado Sicilia, Aina Gomila‐Grange, Sonia Calzado Isbert, Nerea Carrasco Antón, Elizabet Petkova-Saiz, Alfonso Cabello, Miguel Górgolas Hernández-Mora, Olga Sánchez‐Pernaute, Carlos Dueñas Gutiérrez, Javier Miguel Martín Guerra, Javier Castrodeza, Virginia Fernández-Espinilla, Laura Rodríguez Fernández, Juan González‐Moreno, Aroa Villoslada Gelabert, María Antonia Ribot Sanso, María Victoria Fernández-Baca, Almudena Hernández Milian, Miguel Ángel Morán Rodríguez, Zuriñe Ortiz de Zárate Ibarra, José Joaquín Portu Zapirain, Ester Saez de Adana Arroniz, Juan Carlos Gainzarain Arana, Olga Meca Birlanga, Ma Jesús del Amor Espín, Montserrat Viqueira González, Josefina García García, Onofre Martínez Madrid, Enrique Bernal, Antonia Alcaraz, Ángeles Muñoz, Ignacio Pina, Vicente de la Rosa, Tamara Caínzos Romero, Sabela Sánchez Trigo, Ana Isabel Mariño Callejo, Hortensia Álvarez Díaz, Nieves Valcarce Pardeiro, Adriana Sánchez Serrano, Diana Piñar Cabezos, Eva Pilar García Villalba, Carmen Aguayo Jiménez, María Ruíz Campuzano, Virginia Naranjo Velasco, Marta Santos Peña, Juan Mora-Delgado, Israel Sevilla Moreno, Cristina Lojo-Cruz, Xabier Kortajarena Urkola, José Antonio Iribarren Loyarte, María Jesús Bustinduy Odriozola, Maialen Ibarguren Pinilla, Ignacio Álvarez Rodríguez, Francisco Javier Martínez Marcos, Francisco Javier Rodríguez‐Gómez, Isabel Asschert Agüero, Francisco Muñoz Beamud, Antonio José Ruiz Reina, Jara Llenas‐García, Inmaculada González‐Cuello, Elena Hellín-Valiente, Esther Martínez Birlanga, José Manuel Tafalla Torres, Jorge Calderón‐Parra, Gabriela Escudero López, Isabel Gutiérrez, Ane Andrés Eisenhofer, Sonia García, Raquel Álvarez Franco, Daniel Roger Zapata, Blanca Martínez Cifre, Elena Aranda Rife, Irene Martín Rubio, André Barbosa Ventura, J.J Lerma Garrido, Concepción Gonzalo, Iván Piñero,
ObjectivesThe objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.MethodsA cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate- ...
Elsevier BV
Marcela Garzón-Tituaña, José Luis Sierra-Monzón, Laura Comas, Llipsy Santiago, Tatiana Khaliulina-Ushakova, Iratxe Uranga-Murillo, Ariel Ramírez-Labrada, Elena Tapia, Elena Morte-Romea, Sonia Algarate, Ludovic Couty, Eric Camerer, Phillip I. Bird, Cristina Seral, Pilar Luqué, José Ramón Paño‐Pardo, Eva M. Gálvez, Julián Pardo, Maykel Arias,
Aims: Peritonitis is one of the most common causes of sepsis, a serious syndrome characterized by a dysregulated systemic inflammatory response. Recent evidence suggests that Granzyme A (GzmA), a serine protease mainly expressed by NK and T cells, could act as a proinflammatory mediator and could play an important role in the pathogenesis of sepsis. This work aims to analyze the role and the therapeutic potential of GzmA in the pathogenesis of peritoneal sepsis. Methods: The level of extracellular ...
Tópico(s): Immune Response and Inflammation
2021 - Ivyspring International Publisher | Theranostics
Martín Molina, José Luis Sierra, José Cuena,
In computer science, different types of reusable components for building software applications were proposed as a direct consequence of the emergence of new software programming paradigms. The success of these components for building applications depends on factors such as the flexibility in their combination or the facility for their selection in centralised or distributed environments such as internet. In this article, we propose a general type of reusable component, called primitive of representation, ...
Tópico(s): AI-based Problem Solving and Planning
1999 - World Scientific | International Journal of Software Engineering and Knowledge Engineering
Jorge Rubio‐Gracia, Ignacio Gíménez, Vanesa Garcés‐Horna, Daniel López-Delgado, José Luis Sierra-Monzón, Luis Martínez‐Lostao, Claudia Josa‐Laorden, Fernando Ruiz-Laiglesia, Juan Ignacio Pérez‐Calvo, Silvia Crespo-Aznárez, Javier García-Lafuente, Natacha Peña Fresneda, Beatriz Amores Arriaga, Borja Gracia-Tello, Marta Sánchez‐Marteles,
Background Lung ultrasound is feasible for assessing lung injury caused by coronavirus disease 2019 (COVID-19). However, the prognostic meaning and time-line changes of lung injury assessed by lung ultrasound in COVID-19 hospitalised patients are unknown. Methods Prospective cohort study designed to analyse prognostic value of lung ultrasound in COVID-19 patients by using a quantitative scale (lung ultrasound Zaragoza (LUZ)-score) during the first 72 h after admission. The primary end-point was in- ...
Tópico(s): Phonocardiography and Auscultation Techniques
2021 - European Respiratory Society | European Respiratory Journal
Hugo G. Castelán‐Sánchez, Paola Elorrieta, Pedro Romoacca, Arturo Liñan-Torres, José Luis Sierra-Monzón, Ingrid Vera, Ramón Alberto Batista‐García, Silvia Tenorio‐Salgado, Gabriel Lizama‐Uc, Ernesto Pérez‐Rueda, María Antonieta Quispe-Ricalde, Sonia Dávila‐Ramos,
Intermediate-salinity environments are distributed around the world. Here, we present a snapshot characterization of two Peruvian thalassohaline environments at high altitude, Maras and Acos, which provide an excellent opportunity to increase our understanding of these ecosystems. The main goal of this study was to assess the structure and functional diversity of the communities of microorganisms in an intermediate-salinity environment, and we used a metagenomic shotgun approach for this analysis. ...
Tópico(s): Bacteriophages and microbial interactions
2019 - Multidisciplinary Digital Publishing Institute | Genes
Félix Buendía, Joaquín Gayoso-Cabada, José Luis Sierra,
Tópico(s): Digital Rights Management and Security
2019 - Springer Science+Business Media | Journal of Medical Systems
Joaquín Gayoso-Cabada, Daniel Rodríguez-Cerezo, José-Luis Sierra,
Faceted thesauri group classification terms into hierarchically arranged facets. They enable faceted browsing, a well-known browsing technique that makes it possible to narrowing down digital collections by recursively adding filtering terms from the facet hierarchy. In this paper we develop an approach to achieve faceted browsing in live collections, in which not only the contents but also the thesauri can be constantly reorganized. For this purpose we start by introducing a faceted thesauri-based ...
Tópico(s): Advanced Database Systems and Queries
2017 - Springer International Publishing | Lecture notes in information systems and organisation
Juan Cigarrán-Recuero, Joaquín Gayoso-Cabada, Miguel Rodríguez-Artacho, Dolores Romero López, Antonio Sarasa Cabezuelo, José Luis Sierra,
This paper describes an approach to assessing semantic annotation activities based on formal concept analysis (FCA). In this approach, annotators use taxonomical ontologies created by domain experts to annotate digital resources. Then, using FCA, domain experts are provided with concept lattices that graphically display how their ontologies were used during the semantic annotation process. In consequence, they can advise annotators on how to better use the ontologies, as well as how to refine these ...
Tópico(s): Service-Oriented Architecture and Web Services
2014 - Elsevier BV | Expert Systems with Applications
Juan Manuel Dodero, Francisco José García‐Peñalvo, Carina Soledad González González, Pablo Moreno‐Ger, Miguel Á. Redondo, Antonio Sarasa Cabezuelo, José Luis Sierra,
As result of the discussions maintained at the panel session on Software Development for e-Learning of the third workshop on software engineering for e-Learning (ISELEAR'12), several points of view emerged regarding the conception, development, and maintenance of e-Learning solutions. This paper summarizes and confronts these points of view: 1) automated approaches; 2) combination of different methodologies; 3) emphasis on human and social aspects; 4) domain-specific development approaches, 5) model- ...
Tópico(s): Innovative Teaching and Learning Methods
2014 - Institute of Electrical and Electronics Engineers | IEEE Revista Iberoamericana de Tecnologias del Aprendizaje
Beatriz Sarriá, Sara Martínez‐López, José Luis Sierra-Cinos, Luis García‐Diz, Luis Goya, Raquel Mateos, Laura Bravo,
Cocoa manufacturers are producing novel products increasing polyphenols, methylxanthines or dietary fibre to improve purported health benefits. We attempt to explain the contribution of cocoa bioactive compounds to cardiovascular effects observed in previous studies, placing particular emphasis on methylxanthines. We focused on a soluble cocoa product rich in dietary fibre (DFCP) and a product rich in polyphenols (PPCP). Effects of regularly consuming DFCP (providing daily 10.17 g, 43.8 mg and 168. ...
Tópico(s): Fatty Acid Research and Health
2014 - Elsevier BV | Food Chemistry
Sara Martínez‐López, Beatriz Sarriá, José Luis Sierra-Cinos, Luis Goya, Raquel Mateos, Laura Bravo,
To assess whether antioxidant, anti-inflammatory and other cardio-protective effects attributed to cocoa are achieved when regularly consuming moderate amounts of a flavanol-rich soluble cocoa product, a non-randomized, controlled, crossover, free-living study was carried out in healthy (n = 24; 25.9 ± 5.6 years) and moderately hypercholesterolemic (200-240 mg dL(-1); n = 20; 30.0 ± 10.3 years) volunteers. Participants consumed two servings per day (7.5 g per serving) of a soluble cocoa product (providing 45. ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2013 - Royal Society of Chemistry | Food & Function
Beatriz Sarriá, Sara Martínez‐López, José Luis Sierra-Cinos, Luis García‐Diz, Raquel Mateos, Laura Bravo,
Cocoa products present great health potential due to their high content of polyphenols, mainly of flavanols. However, the antioxidant, anti-inflammatory and other health effects of regularly consuming cocoa products seem to depend on the intake and health status of the consumer, etc. and need to be further clarified. A randomised, controlled, cross-over, free-living study was carried out in healthy ( n 24) and moderately hypercholesterolaemic (>2000 mg/l, n 20) subjects to assess the influence of regularly ...
Tópico(s): Fatty Acid Research and Health
2013 - Cambridge University Press | British Journal Of Nutrition
Daniel Rodríguez-Cerezo, Antonio Sarasa Cabezuelo, Mercedes Gómez-Albarrán, José Luis Sierra,
Tópico(s): Teaching and Learning Programming
2013 - Elsevier BV | Computers in Human Behavior