From Terence Smith, By Paul Routledge Labour Correspondent, By Hugh Clayton, From Harry Debelius, By Maurice Corina Industrial Editor, From Our Correspondent, By David Leigh, By Stewart Tendler, From Robert Fisk, By Our Political Staff, By Patricia Tisdall, By Alan Hamilton Labour Staff, By Our Planning Reporter, From Roger Berthoud, From Our Own Correspondent, From Paul Martin, From Our Special Correspondent, From Moshe Brilliant, From Jose Shercliff, By Henry Stanhope Defence Correspondent, From Michael Knipe, From Dessa Trevisan, Marvin Lyons, Edward Mayer, Paul Overy, Ronald Hayman, Stanley Sadie, William Mann, Joan Chissell, Peter Vansittart, Roy Hay, Harry Golombek, John Carter, Lord Gladwyn, Geoffrey Green, Alison Ross, Baron Moss, JOHN GRIFFIN., D. C. MANDEVILLE., BRIAN H. MACDERMOT., H. L. BENJAMIN, , ALAN MAYNARD., H. GEOFFREY WOOLFE., DAVID BARRAN, JOHN KISSIN., MICHAEL CHANCE, HUGO BALL., LEWIS STRETCH, , ARTHUR PHILLIPS., JOHN STOKES., P. S. YOUNG., P. H. H. MOORE, , Cyril Bainbridge, From John Young Planning Reporter Cheddar, By Angela Tilby, From Seton Gordon, By John Woodcock Cricket Correspondent, By Peter Marson, By John Woodcock, From John Hopkins, By Norman Fox, By Michael Phillips Racing Correspondent, By Jim Snow Northern Racing Correspondent, From Pierre Guillot French Racing Correspondent, By Pamela Macgregor-Morris, By Andrew Porter, By Peter Ryde Golf Correspondent, By John Nicholls, By Lewine Mair, From Frank Vogl, By Clifford Webb, By Andrew Wilson, By R. W. Shakespeare Northern Industrial Correspondent, By John Whitmore, By Edward Townsend, By Terry Byland, John Drummond, JD, MS, EDITED BY MARGARET STONE, FE, By Our Financial Staff,
... up their challenge, Southern Cross should clinch series, Villanueva faces Garbey for fifth time. Editorials/Leaders: Chinese ... Bay, Comm Bank, Australia, Domecq taking control of Luis Gordon, Poles sign £150m deal with Massey combine, ...
1974 - Gale Group | TDA
Fernando Ballester Laguna, José Miguel Cisneros, Víctor Pérez-Moreno, José Villanueva, Eulalia Valencia,
... on: Oxford Academic PubMed Google Scholar José Luis Villanueva, José Luis Villanueva Infectious Diseases Service, Centro de Investigation Clinica, Madrid, ...
Tópico(s): Trypanosoma species research and implications
1995 - Oxford University Press | Clinical Infectious Diseases
Julián Torre‐Cisneros, José Villanueva,
... on: Oxford Academic PubMed Google Scholar Jose Luis Villanueva Jose Luis Villanueva Hospital Reina Sofia, Cordoba, Spain Search for other ...
Tópico(s): Eosinophilic Esophagitis
1995 - Oxford University Press | Clinical Infectious Diseases
José Luís Prada, José Luis Villanueva‐Cañas, Julián Torre‐Cisneros, Facundo Rodríguez, María-José López-Espinosa, Manuel Anguita,
... SofiaCordoba, Spain Correspondence and offprint requests to: Dr José Luis Villanueva Marcos, Unidad de Enfermedades Infecciosas, Hospital Reina Sofia ( ...
Tópico(s): Mycobacterium research and diagnosis
1994 - Oxford University Press | Nephrology Dialysis Transplantation
Raquel Tarazona, Olga DelaRosa, Javier G. Casado, Julián Torre‐Cisneros, José Luis Villanueva‐Cañas, M.D. Galiani, José D. Torres‐Peña, Rafael Solana,
Objectives This study addresses the detailed expression of natural killer (NK)- associated receptors on CD8 T lymphocytes in treatment-naive HIV-infected individuals. Design Experimental study analysing the expression of NK-associated receptors on peripheral blood T lymphocytes from HIV-infected individuals compared with healthy controls. Methods Flow cytometry was used to analyse the expression of CD56, CD16, CD94, NKG2A, NKB1, CD161, CD244, and perforin, according to the CD28 phenotype, on CD8bright ...
Tópico(s): T-cell and B-cell Immunology
2002 - Lippincott Williams & Wilkins | AIDS
Daniel Villanueva, José Luis Echarte Pazos, Andrés Feijóo,
In this paper, a procedure is established for calculating the load flow probability density function in an electrical power network, taking into account the presence of wind power generation. The probability density function of the power injected in the network by a wind turbine is first obtained by utilizing a quadratic approximation of its power curve. With this model, the DC power flow of a network is calculated, considering the probabilistic nature of the power injected or consumed by the generators ...
Tópico(s): Power System Reliability and Maintenance
2011 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Systems
Cuauhtémoc Sánchez-Ramírez, Miguel Gastón Cedillo‐Campos, Pedro Perez-Villanueva, José Luis Martínez Flores,
The impact of the global economic crisis on the Mexican automotive suppliers and its effects on the labor capital are analyzed. Owing to the complexity of the subsystems involved in the automotive industry, a system dynamics approach was selected to develop the simulation model based on a case study. Nevertheless, because of the standard structure of the proposed model, it can be generalized to other automotive companies. The model provides a detailed causal analysis of how supply networks and local ...
Tópico(s): Innovation and Socioeconomic Development
2011 - SAGE Publishing | SIMULATION
Andrés Feijóo, Daniel Villanueva, José Luis Echarte Pazos, Robert Adam Sobolewski,
This paper presents the evolution of techniques for simulating correlated wind speeds, over the last decade. The work stems from the problem of obtaining a value that can be defined as the simultaneousness of the production of wind power in electrical networks containing many wind parks. As will be seen, we have steadily extended the research towards the analysis of the correlation of wind speed series at several locations, which is important for assessing the probability of a given wind power being ...
Tópico(s): Thermal Analysis in Power Transmission
2011 - Elsevier BV | Renewable and Sustainable Energy Reviews
Rodrigo A. Villanueva, José Luis Galaz, Juan Antonio Valdés, M Jashés, Ana María Sandino,
In this study, we have analyzed the morphogenesis of the birnavirus infectious pancreatic necrosis virus throughout the infective cycle in CHSE-214 cells by using a native agarose electrophoresis system. Two types of viral particles (designated A and B) were identified, isolated, and characterized both molecularly and biologically. Together, our results are consistent with a model of morphogenesis in which the genomic double-stranded RNA is immediately assembled, after synthesis, into a large (66- ...
Tópico(s): Animal Virus Infections Studies
2004 - American Society for Microbiology | Journal of Virology
Carolina Camacho-Vázquez, Eliel Ruíz-May, José A. Guerrero‐Analco, José M. Elizalde‐Contreras, Erick J. Enciso-Ortiz, Greta Rosas-Saito, Lorena López-Sánchez, Ana L. Kiel-Martínez, Israel Bonilla‐Landa, Juan L. Monribot–Villanueva, José Luis Olivares‐Romero, Porfirio Gutiérrez-Martínez, Julio César Tafolla-Arellano, Martín Ernesto Tiznado-Hérnández, Francisco Roberto Quiroz‐Figueroa, Andrea Birke, Martı́n Aluja,
The cuticle is a critical barrier covering the surface of plant aerial organs. It is associated with important physiological and biological fruit traits, but few studies on this structure have been conducted in tropical fruit such as mango. Here, we have reported on a detailed investigation on the cuticle of six cultivars of mangoes (Kent, Tommy Atkins, Manila, Ataulfo, Criollo and Manililla), by combining several advanced microscopy tools and chemical analyses. All mango cultivars exhibited high ...
Tópico(s): Forest Insect Ecology and Management
2018 - Elsevier BV | Postharvest Biology and Technology
Francisco R. de la Peña, Carlos Cruz-Fuentes, Lino Palacios, Manuel Iván Girón‐Pérez, Emilio Medina‐Rivero, María Dolores Ponce-Regalado, Samantha Álvarez-Herrera, Gilberto Pérez‐Sánchez, Enrique Becerril‐Villanueva, José Luis Maldonado-García, María del Carmen Jiménez Martínez, Lenin Pavón,
Major depressive disorder (MDD) is a global health issue that affects 350 million people of all ages. Although between 2% and 5.6% of affected individuals are adolescents, research on young patients is limited. The inflammatory response contributes to the onset of depression, and in adult MDD patients, symptom severity has been linked to chemokine levels.To determine the differences in circulatory levels of chemokines in healthy volunteers (HVs) and adolescents with MDD, and assess the changes induced ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2020 - Baishideng Publishing Group | World Journal of Psychiatry
José Luis Villanueva‐Cañas, Jaime González‐Domínguez, Raquel González-Fernández, José Luís Prada, José D. Torres‐Peña, Rafael Solana,
Behçet9s disease is a multisystemic disease affecting most organs. Although a tendency towards an association with a certain genetic type and with HLA-B51 is suspected, the incidence of several siblings with Behçet9s disease in a single family is rare. A family, in which three sisters were affected with Behçet9s disease, uveitis being the most severe manifestation, was studied. In this family all siblings were B51 positive. Only the female siblings, however, with a positive identical HLA phenotype: ...
Tópico(s): Systemic Lupus Erythematosus Research
1993 - BMJ | Annals of the Rheumatic Diseases
Albert Pujol, Juan J. Villanueva, José Luis Alba‐Castro,
Hausdorff distance is a deformation tolerant measure between two sets of points. The main advantage of this measure is that it does not need an explicit correspondence between the points of the two sets. This paper presents the application to automatic face recognition of a novel supervised Hausdorff-based measure. This measure is designed to minimize the distance between sets of the same class (subject) and at the same time maximize the distance of sets between different classes.
Tópico(s): Advanced Image and Video Retrieval Techniques
2002 - World Scientific | International Journal of Pattern Recognition and Artificial Intelligence
Estebán Martínez, José M. Miró, Benito Almirante, José María Aguado, P Fernández-Viladrich, Manuel L. Fernández-Guerrero, José Luis Villanueva‐Cañas, Fernando Dronda, Alfonso Moreno‐Torrico, Miguel Montejo, Pedro Llinares, José M. Gatell,
We performed a clinical study of pneumococcal endocarditis (PE) in adults at 15 major Spanish hospitals during a 21-year period (1978-1998). During this time, 63 patients had PE due to Streptococcus pneumoniae diagnosed. Of the 63 isolates recovered from these patients, 24 (38%) and 6 (10%) showed resistance to penicillin (minimum inhibitory concentration [MIC], 0.1-4 microg/mL) and cefotaxime (MIC, 1 microg/mL), respectively. Twenty-two (35%) of the patients died. Left-side heart failure, but not penicillin ...
Tópico(s): Bacterial Infections and Vaccines
2002 - Oxford University Press | Clinical Infectious Diseases
Raquel Tarazona, Javier G. Casado, Olga DelaRosa, Julián Torre‐Cisneros, José Luis Villanueva‐Cañas, Berta Sánchez, M.D. Galiani, Rafael González Manzanares, Rafael Solana, José Peña,
Tópico(s): T-cell and B-cell Immunology
2002 - Springer Science+Business Media | Journal of Clinical Immunology
Francisco J. Caballero, José Miguel Cisneros, Ruth Luque, M. Torres-Tortosa, Fernando Gamboa, Díez García F, José Luis Villanueva‐Cañas, Ramón Pérez‐Cano, Juan Pasquau, Dolores Merino, A. Menchero, Delio José Mora, Miguel Ángel López‐Ruz, A. Vergara, for the Grupo Andaluz Para El Estudio De Las Enfermedades Infecciosas,
ABSTRACT A prospective, multicenter study was carried out over a period of 10 months. All patients with clinically significant bacteremia caused by Enterococcus spp. were included. The epidemiological, microbiological, clinical, and prognostic features and the relationship of these features to the presence of high-level resistance to gentamicin (HLRG) were studied. Ninety-three patients with enterococcal bacteremia were included, and 31 of these cases were caused by HLRG (33%). The multivariate analysis ...
Tópico(s): Antibiotic Use and Resistance
1998 - American Society for Microbiology | Journal of Clinical Microbiology
Felipe Barrera‐Méndez, Diter Augusto Miranda Sánchez, Diana Sánchez-Rangel, Israel Bonilla‐Landa, Benjamín Rodríguez‐Haas, Juan L. Monribot–Villanueva, José Luis Olivares‐Romero,
The nanoencapsulation of pesticides in biodegradable polymers confers several advantages to conventional agrochemicals, such as protection against losses due volatilization and degradation of the active ingredient, as well as the augment of water dispersion, allowing for their application on crops without requiring the use of organic solvents that could harm the user and the environment. This characteristics could enhance the productivity, reducing both costs and environmental pollution. In this ...
Tópico(s): Polymer-Based Agricultural Enhancements
2019 - Mexican Chemical Society | Journal of the Mexican Chemical Society
Rafael Solana, José Luis Villanueva‐Cañas, J. Pen ̃a, Mónica De la Fuente,
Among the age-associated changes in the immune system, the most evident is the decrease in proliferative responses of lymphocytes to mitogenic stimuli, which is accompanied by the loss of cytokine network homeostasis. Chronic low-grade inflammatory stress, termed as sterile inflammation, is also observed during aging. In chronologically and prematurely aging mice, cohabitation with adult animals for two months favored improvements in several immune functions. This study aimed to determine whether ...
Tópico(s): Tryptophan and brain disorders
1991 - Elsevier BV | Comparative Biochemistry and Physiology Part A Physiology
Benito Lorenzo-Pajuelo, José Luis Villanueva‐Cañas, Juan Rodríguez‐Cuesta, Nuria Vergara‐Irigaray, Máximo Bernabéu-Wittel, A. García-Curiel, Guillermo Martínez de Tejada,
Although Bordetella bronchiseptica can infect and colonize immunocompromised humans, its role as a primary pathogen in pneumonia and other respiratory processes affecting those patients remains controversial. A case of cavitary pneumonia caused by B. bronchiseptica in an AIDS patient is presented, and the basis of the seemingly enhanced pathogenic potential of this isolate (designated 814) is investigated. B. bronchiseptica was the only microorganism recovered from sputum, bronchoalveolar lavage ...
Tópico(s): Diphtheria, Corynebacterium, and Tetanus
2002 - American Society for Microbiology | Journal of Clinical Microbiology
José Luis Villanueva‐Cañas, Angel Domínguez, María Rios, C. Iglesias,
AbstractAn 82-y-old male patient with a neurogenic bladder and vesical stones presented with a urinary tract infection caused by Corynebacterium macginleyi. This is the first case of isolation of C. macginleyi from a non-conjunctival specimen. The patient recovered fully with antimicrobial treatment.
Tópico(s): Clostridium difficile and Clostridium perfringens research
2002 - Informa | Scandinavian Journal of Infectious Diseases
Arı́stides de Alarcón, José Luis Villanueva‐Cañas, Pompeyo Viciana, Luís F. López‐Cortés, Rafael Torronteras, Máximo Bernabéu-Wittel, Elisa Cordero, Jerónimo Pachón,
Objectives. Clinical polymorphism is a main feature of Q fever and, depending upon the geographic location, differences in its clinical picture have been described. The objective of this study was to determine the epidemiology, clinical features and prognosis of acute Q fever in our area. Methods. From 1985 to 1999, consecutive cases of Q fever, presented as febrile syndrome and attended in a tertiary teaching hospital in Sevilla, Spain, were included and followed prospectively. Results. Two hundred ...
Tópico(s): Viral Infections and Vectors
2003 - Elsevier BV | Journal of Infection
José Luis Villanueva‐Cañas, Sheena L. Faherty, Anne D. Yoder, M. Mar Albà,
In recent years, the study of the molecular processes involved in mammalian hibernation has shifted from investigating a few carefully selected candidate genes to large-scale analysis of differential gene expression. The availability of high-throughput data provides an unprecedented opportunity to ask whether phylogenetically distant species show similar mechanisms of genetic control, and how these relate to particular genes and pathways involved in the hibernation phenotype. In order to address ...
Tópico(s): Physiological and biochemical adaptations
2014 - Oxford University Press | Integrative and Comparative Biology
José Luis Villanueva‐Cañas, Steven Laurie, M. Mar Albà,
Large-scale evolutionary studies often require the automated construction of alignments of a large number of homologous gene families. The majority of eukaryotic genes can produce different transcripts due to alternative splicing or transcription initiation, and many such transcripts encode different protein isoforms. As analyses tend to be gene centered, one single-protein isoform per gene is selected for the alignment, with the de facto approach being to use the longest protein isoform per gene ( ...
Tópico(s): Machine Learning in Bioinformatics
2013 - Oxford University Press | Genome Biology and Evolution
Máximo Bernabéu-Wittel, Jerónimo Pachón, Arístides de Alarcón, Luís F. López‐Cortés, Pompeyo Viciana, Jiménez-Mejías Me, José Luis Villanueva‐Cañas, R. Torronteras, Francisco J. Caballero,
Fever of intermediate duration (FID), characterized by a febrile syndrome lasting from 7 to 28 days, is a frequent condition in clinical practice, but its epidemiological and etiologic features are not well described. Murine typhus (MT) is a worldwide illness; nevertheless, to our knowledge, no studies describing its epidemiological and clinical characteristics have been performed in the south of Spain. Also, its significance as a cause of FID is unknown.To determine the epidemiological features, ...
Tópico(s): Viral Infections and Vectors
1999 - American Medical Association | Archives of Internal Medicine
José Luis Villanueva‐Cañas, Gabriel E. Rech, M. Cara, Josefa González,
Summary Identifying the genomic basis of adaptive evolution is a growing field of research. The number of statistics and methodologies aimed at identifying adaptive loci continues to increase. Moreover, the availability of whole‐genome sequences allows us to make inferences of selection on a diverse set of species. However, detecting footprints of selection has mostly been restricted to one type of genomic variation: single‐nucleotide polymorphisms (SNPs). Other genomic variants such as transposable ...
Tópico(s): Genomics and Phylogenetic Studies
2017 - Wiley | Methods in Ecology and Evolution
José Luis Villanueva‐Cañas, Jorge Ruiz‐Orera, M. Isabel Agea, Maria Gallo, David Andreu, M. Mar Albà,
Abstract The birth of genes that encode new protein sequences is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions they are selected for. To address these questions, we have obtained a large collection of mammalian-specific gene families that lack homologues in other eukaryotic groups. We have combined gene annotations and de novo transcript assemblies from 30 different mammalian species, obtaining ∼ ...
Tópico(s): Genomics and Phylogenetic Studies
2017 - Oxford University Press | Genome Biology and Evolution
Sheena L. Faherty, José Luis Villanueva‐Cañas, Marina B. Blanco, M. Mar Albà, Anne D. Yoder,
Abstract Hibernation is an adaptive strategy some mammals use to survive highly seasonal or unpredictable environments. We present the first investigation on the transcriptomics of hibernation in a natural population of primate hibernators: Crossley's dwarf lemurs ( Cheirogaleus crossleyi ). Using capture–mark–recapture techniques to track the same animals over a period of 7 months in Madagascar, we used RNA‐seq to compare gene expression profiles in white adipose tissue (WAT) during three distinct physiological ...
Tópico(s): Primate Behavior and Ecology
2018 - Wiley | Molecular Ecology
François Le Dily, Enrique Vidal, Yasmina Cuartero, Javier Quilez, A. Silvina Nacht, Guillermo P. Vicent, José Carbonell‐Caballero, Priyanka Sharma, José Luis Villanueva‐Cañas, Roberto Ferrari, Lara Isabel de Llobet Cucalon, Gaetano Verde, Roni H. G. Wright, Miguel Beato,
In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. Here we further describe that responsive TADs contain 20- to 100-kb-long clusters of intermingled estrogen receptor (ESR1) and progesterone receptor (PGR) binding sites, hereafter called hormone-control regions (HCRs). In T47D cells, we identified more than 200 HCRs, which are frequently bound by unliganded ...
Tópico(s): RNA Research and Splicing
2018 - Cold Spring Harbor Laboratory Press | Genome Research
Jorge Ruiz‐Orera, Pol Verdaguer-Grau, José Luis Villanueva‐Cañas, Xavier Messeguer, M. Mar Albà,
Accumulating evidence indicates that some protein-coding genes have originated de novo from previously non-coding genomic sequences. However, the processes underlying de novo gene birth are still enigmatic. In particular, the appearance of a new functional protein seems highly improbable unless there is already a pool of neutrally evolving peptides that are translated at significant levels and that can at some point acquire new functions. Here, we use deep ribosome-profiling sequencing data, together ...
Tópico(s): Machine Learning in Bioinformatics
2018 - Nature Portfolio | Nature Ecology & Evolution
José Luis Villanueva‐Cañas, Vivien Horváth, Laura Aguilera, Josefa González,
Although transposable elements are an important source of regulatory variation, their genome-wide contribution to the transcriptional regulation of stress-response genes has not been studied yet. Stress is a major aspect of natural selection in the wild, leading to changes in the transcriptional regulation of a variety of genes that are often triggered by one or a few transcription factors. In this work, we take advantage of the wealth of information available for Drosophila melanogaster and humans ...
Tópico(s): Genomics and Phylogenetic Studies
2019 - Oxford University Press | Nucleic Acids Research