Pablo Estévez, Manoëlla Sibat, José Manuel Leão, Pedro Reis Costa, Ana Gago‐Martínez, Philipp Heß,
Ciguatera poisoning (CP) is a common seafood intoxication mainly caused by the consumption of fish contaminated by ciguatoxins. Recent studies showed that Caribbean ciguatoxin-1 (C-CTX1) is the main toxin causing CP through fish caught in the Northeast Atlantic, e.g., Canary Islands (Spain) and Madeira (Portugal). The use of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) combined with neuroblastoma cell assay (N2a) allowed the initial confirmation of the presence of C-CTX1 in contaminated ...
Tópico(s): Neuroscience of respiration and sleep
2020 - Multidisciplinary Digital Publishing Institute | Toxins
Pedro Reis Costa, Jorge Giráldez, Susana Margarida Rodrigues, José Manuel Leão, Estefanía Pereira Pinto, Lucía Soliño, Ana Gago‐Martínez,
Tetrodotoxin (TTX) is a potent neurotoxin, considered an emerging toxin in Europe where recently a safety limit of 44 µg TTX kg
Tópico(s): Forensic Toxicology and Drug Analysis
2021 - Multidisciplinary Digital Publishing Institute | Toxins
Produção Nacional
Marta Pojo, Céline S. Gonçalves, Ana Xavier‐Magalhães, Ana I. Oliveira, Tiago Gonçalves, Sara Correia, Ana João Rodrigues, Sandra Costa, Luísa Pinto, Afonso A. Pinto, José Manuel Lopes, Rui Manuel Reis, Miguel Rocha, Nuno Sousa, Bruno M. Costa,
// Marta Pojo 1, 2 , Céline S. Gonçalves 1, 2 , Ana Xavier-Magalhães 1, 2 , Ana Isabel Oliveira 1, 2 , Tiago Gonçalves 1, 2 , Sara Correia 3 , Ana J. Rodrigues 1, 2 , Sandra Costa 1, 2 , Luísa Pinto 1, 2 , Afonso A. Pinto 4 , José M. Lopes 5, 6, 7 , Rui M. Reis 1, 2, 8 , Miguel Rocha 3 , Nuno Sousa 1, 2 , Bruno M. Costa 1, 2 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar 4710–057 Braga, Portugal 2 ICVS/3B's—PT Government Associate Laboratory, Braga/Guimarães, ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2015 - Impact Journals LLC | Oncotarget
Produção Nacional
Ângela M. Costa, Filipe Pinto, Olga Martinho, Maria José Oliveira, Peter Jordan, Rui Manuel Reis,
// Angela Margarida Costa 1, 2 , Filipe Pinto 1, 2 , Olga Martinho 1, 2 , Maria José Oliveira 3 , Peter Jordan 4, 5 , Rui Manuel Reis 1, 2, 6 1 ICVS-Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, ...
Tópico(s): S100 Proteins and Annexins
2014 - Impact Journals LLC | Oncotarget
Pedro Reis Costa, Pablo Estévez, Lucía Soliño, David Castro, Susana Margarida Rodrigues, Viriato Timóteo, José Manuel Leão, Carolina Santos, Neide Gouveia, Jorge Diogène, Ana Gago‐Martínez,
The Selvagens Islands, which are a marine protected area located at the southernmost point of the Portuguese maritime zone, have been associated with fish harboring ciguatoxins (CTX) and linked to ciguatera fish poisonings. This study reports the results of a field sampling campaign carried out in September 2018 in these remote and rarely surveyed islands. Fifty-six fish specimens from different trophic levels were caught for CTX-like toxicity determination by cell-based assay (CBA) and toxin content ...
Tópico(s): Forensic Toxicology and Drug Analysis
2021 - Multidisciplinary Digital Publishing Institute | Toxins
Bruno M. Costa, Cláudia Caeiro, Inês Guimarães, Olga Martinho, Teresa Jaraquemada, I. Augusto, Lígia Castro, Lígia Osório, Paulo Linhares, Mrinalini Honavar, Mário Resende, Fátima Braga, Ana Martins da Silva, Fernando Pardal, Júlia Amorim, Rui Nabiço, Rui Almeida, Carlos Alegria, Manuel Melo Pires, Célia Pinheiro, Ernesto Carvalho, José Manuel Lopes, Paulo Costa, Margarida Damasceno, Rui Manuel Reis,
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-specific PCR in 90 GBM patients from four Portuguese hospitals, uniformly treated with radiotherapy ...
Tópico(s): Brain Metastases and Treatment
2010 - Elsevier BV | Oncology Reports
Produção Nacional
Revisado por pares
Olga Martinho, Sara Granja, Teresa Jaraquemada, Cláudia Caeiro, Vera Miranda‐Gonçalves, Mrinalini Honavar, Paulo Costa, Margarida Damasceno, Marsha Rich Rosner, José Manuel Lopes, Rui Manuel Reis,
Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis and prognosis in several human neoplasms. Its role in the prognosis and tumourigenesis ...
Tópico(s): Mechanisms of cancer metastasis
2012 - Public Library of Science | PLoS ONE
Pedro Reis Costa, Pablo Estévez, David Castro, Lucía Soliño, Neide Gouveia, Carolina Santos, Susana Margarida Rodrigues, José Manuel Leão, Ana Gago‐Martínez,
Ciguatoxins (CTXs), endemic from tropical and subtropical regions of the Pacific and Indian Ocean and the Caribbean Sea, have caused several human poisonings during the last decade in Europe. Ciguatera fish poisonings (CFP) in Madeira and Canary Islands appear to be particularly related with consumption of fish caught close to Selvagens Islands, a Portuguese natural reserve composed of three small islands that harbor high fish biomass. In this study, fish specimens considered as potential vectors ...
Tópico(s): Cassava research and cyanide
2018 - Multidisciplinary Digital Publishing Institute | Toxins
Vítor Lima-Ramos, Luís Pacheco‐Figueiredo, Sandra Costa, Fernando Pardal, Ana Silva, Júlia Amorim, José Manuel Lopes, Rui Manuel Reis,
TP53 is a key tumor suppressor gene that encodes a transcriptional factor involved in several cellular mechanisms, including growth arrest, DNA repair, and induction of apoptosis.In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.The Pro72 variant has been associated with a slower induction of apoptosis and may influence the risk of cancer development.The role of Arg72Pro polymorphism in glioma susceptibility is poorly characterized. ...
Tópico(s): DNA Repair Mechanisms
2007 - Elsevier BV | Cancer Genetics and Cytogenetics
Produção Nacional
Márcia S. Pereira, Sónia Pires Celeiro, Ângela M. Costa, Filipe Pinto, Sergey Popov, Gisele Caravina de Almeida, Júlia Amorim, Manuel Melo Pires, Célia Pinheiro, José Manuel Lopes, Mrinalini Honavar, Paulo Costa, José Pimentel, Chris Jones, Rui Manuel Reis, Marta Viana‐Pereira,
Tópico(s): Cancer, Hypoxia, and Metabolism
2019 - Springer Nature | Cellular Oncology
Produção Nacional
Revisado por pares
Renata Silva Diniz, Jane Sélia dos Reis Coimbra, Álvaro Vianna Novaes de Carvalho Teixeira, Angélica Ribeiro da Costa, Igor José Boggione Santos, Gustavo Costa Bressan, Antonio Manuel da Cruz Rodrigues, Luiza Helena Meller da Silva,
The study of protein interactions has generated great interest in the food industry. Therefore, research on new supramolecular structures shows promise. Supramolecular structures of the whey proteins α-lactalbumin and glycomacropeptide were produced under varying heat treatments (25 to 75°C) and acidic conditions (pH3.5 to 6.5). Isothermal titration calorimetry experiments showed protein interactions and demonstrated that this is an enthalpically driven process. Supramolecular protein structures in ...
Tópico(s): Surfactants and Colloidal Systems
2014 - Elsevier BV | Food Research International
Produção Nacional
Revisado por pares
Allini Mafra da Costa, Aline L. Ribeiro, Adeylson Guimarães Ribeiro, Andrea Gini, Citadel J. Cabasag, Rui Manuel Reis, José Humberto Tavares Guerreiro Fregnani, Isabelle Soerjomataram,
Alongside the SARS-CoV-2 (COVID-19) pandemic, Brazil also faces an ongoing rise in cancer burden. In 2020, there were approximately 592 000 new cancer cases and 260 000 cancer deaths. Considering the heterogeneities across Brazil, this study aimed to estimate the impact of the COVID-19 pandemic on cancer-related hospital admissions at a national and regional level.The national, regional, and state-specific monthly average of cancer-related hospital admission rates per 100 000 inhabitants and 95% ...
Tópico(s): Cancer survivorship and care
2021 - SAGE Publishing | Cancer Control
Produção Nacional
Revisado por pares
Adriane Feijó Evangelista, Renato José da Silva Oliveira, Viviane Aline Oliveira Silva, René Aloísio da Costa Vieira, Rui Manuel Reis, Márcia Maria Chiquitelli Marques,
Abstract Background Breast cancer is the most frequently diagnosed malignancy among women. However, the role of microRNA (miRNA) expression in breast cancer progression is not fully understood. In this study we examined predictive interactions between differentially expressed miRNAs and mRNAs in breast cancer cell lines representative of the common molecular subtypes. Integrative bioinformatics analysis identified miR-193 and miR-210 as potential regulatory biomarkers of mRNA in breast cancer. Several ...
Tópico(s): Circular RNAs in diseases
2021 - BioMed Central | BMC Cancer
Produção Nacional
Gabriela Carvalho Fernandes, Rodrigo Augusto Depieri Michelli, Henrique C.R. Galvão, André Escremim de Paula, Rui Pereira, Carlos Eduardo Mattos Cunha Andrade, Paula Silva Felicio, Cristiano de Pádua Souza, Deise R.P. Mendes, Sáhlua Miguel Volc, Gustavo Nóriz Berardinelli, Rebeca Silveira Grasel, Cristina S. Sabato, Danilo Vilela Viana, José Carlos Machado, José Luís Costa, Edmundo Carvalho Mauad, Cristovam Scapulatempo‐Neto, Banu K. Arun, Rui Manuel Reis, Edenir Inêz Palmero,
There are very few data about the mutational profile of families at-risk for hereditary breast and ovarian cancer (HBOC) from Latin America (LA) and especially from Brazil, the largest and most populated country in LA.Of the 349 probands analyzed, 21.5% were BRCA1/BRCA2 mutated, 65.3% at BRCA1 and 34.7% at BRCA2 gene. The mutation c.5266dupC (former 5382insC) was the most frequent alteration, representing 36.7% of the BRCA1 mutations and 24.0% of all mutations identified. Together with the BRCA1 c. ...
Tópico(s): Genomic variations and chromosomal abnormalities
2016 - Impact Journals LLC | Oncotarget
Produção Nacional
Revisado por pares
Flávia Martins, Rosa Oliveira, Bruno Cavadas, Filipe Pinto, Ana Patrícia Cardoso, Flávia Castro, Bárbara Sousa, Marta L. Pinto, Ana João Silva, Diogo Adão, José Pedro Loureiro, Nicole Pedro, Rui Manuel Reis, Luı́sa Pereira, Maria José Oliveira, Ângela M. Costa,
In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and their association with patient overall survival was established. A positive correlation ...
Tópico(s): Phagocytosis and Immune Regulation
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Produção Nacional
Revisado por pares
Denise Peixoto Guimarães, Larissa Andreoli Mantuan, Marco Antônio de Oliveira, Raphael Luiz, Allini Mafra da Costa, Silvana Rossi, Gilberto Fava, Leonardo Nogueira Taveira, Kelly Giardina, Thais Talarico, Maraisa Costa, Cristovam Scapulatempo‐Neto, Marcus Matsushita, Carlos Augusto Rodrigues Véo, José Humberto Tavares Guerreiro Fregnani, Rui Manuel Reis, Ernest T. Hawk, Edmundo Carvalho Mauad,
Colorectal cancer is the second most common cancer in Brazil. Yet, a nationally organized colorectal screening program is not implemented. Barretos Cancer Hospital (BCH) is one of the largest Brazilian institution that cares for underserved patients. BCH developed a fecal immunochemical test (FIT)-based organized colorectal cancer screening program to improve colorectal cancer outcomes.This study aims to present the quality/performance measures of the first 2 years of the FIT-based colorectal cancer ...
Tópico(s): Colorectal Cancer Surgical Treatments
2020 - American Association for Cancer Research | Cancer Prevention Research
João Pinheiro-Costa, José Mário Martins Costa, João Beato, Paulo Freitas‐da‐Costa, Elisete Brandão, Manuel Falcão, Fernando Falcão‐Reis, Ângela Carneiro,
<b><i>Purpose:</i></b> To report the clinical outcomes of intravitreal aflibercept therapy in eyes with refractory and recurrent neovascular age-related macular degeneration (AMD) switched from intravitreal bevacizumab or ranibizumab. <b><i>Methods:</i></b> This is a retrospective review of eyes with neovascular AMD switched to intravitreal aflibercept with at least 1 year of follow-up after the switch. All patients had had a minimum of 3 injections of ...
Tópico(s): Retinal Development and Disorders
2015 - Karger Publishers | Ophthalmologica
David Castro, Pablo Estévez, José Manuel Leão, Robert Dickey, Natalia García‐Álvarez, F. Real, Pedro Reis Costa, Ana Gago‐Martínez,
Ciguatoxins (CTXs) are naturally occurring neurotoxins that can accumulate in fish and cause Ciguatera Poisoning (CP) in seafood consumers. Ciguatoxic fish have been detected in tropical and subtropical regions of the world including the Pacific and Indian Oceans, the Caribbean Sea, and more recently in the northeast Atlantic Ocean. The biogeographic distribution of ciguatoxic fish appears to be expanding; however, the paucity of CTX standards and reference materials limits the ability of public health ...
Tópico(s): Forensic Toxicology and Drug Analysis
2022 - Multidisciplinary Digital Publishing Institute | Journal of Marine Science and Engineering
Bruno M. Costa, Paulo Michel Pinheiro Ferreira, Sandra Costa, Paulo Canedo, Pedro Oliveira, Ana Silva, Fernando Pardal, Gianpaolo Suriano, José Carlos Machado, José Manuel Lopes, Rui Manuel Reis,
Abstract Purpose: Epidermal growth factor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61 in glioma susceptibility and prognosis. Experimental Design: A case-control study involving 197 glioma patients and 570 controls was done. Univariate and multivariate logistic regression analyses were used to calculate odds ratio ( ...
Tópico(s): Neuroblastoma Research and Treatments
2007 - American Association for Cancer Research | Clinical Cancer Research
Ana Catarina Braga, Raquel Marçal, Ana Marques, Sofia Guilherme, Óscar Vilariño, José Manuel Leão, Ana Gago‐Martínez, Pedro Reis Costa, Mário Pacheco,
This study aims to assess and compare the kinetics (accumulation/elimination) of the marine biotoxins okadaic acid (OA) and dinophysistoxin-1 (DTX1), between native (Ruditapes decussatus) and invasive (Ruditapes philippinarum) clam species, and their genotoxic effects and DNA recover capacity after, exposure to toxic dinoflagellates Prorocentrum lima. Clams were fed with P. lima for 5 days and then to non-toxic algae (post-exposure) during other 5 days. Toxin concentrations determined in clams by LC-MS/ ...
Tópico(s): Marine Ecology and Invasive Species
2021 - Elsevier BV | The Science of The Total Environment
Ana Canals, Carmen Varela Martínez, Jorge Diogène, Ana Gago‐Martínez, Laura Cebadera‐Miranda, Filipa Melo de Vasconcelos, Inmaculada León Gómez, Elena Vanessa Martínez Sánchez, Rocío Carmona Alférez, Domingo Núñez, Miriam Friedemann, Mónica Oleastro, Ioannis S. Boziaris, Maria Rambla-Alegre, Mònica Campàs, Margarita Fernández‐Tejedor, Karl B. Andrée, Àngels Tudó, María Luz Padilla del Rey, Núria Sagristà, Paloma Aguayo, Sandra Leonardo, Vanessa Castan, José Luís Costa, F. Real, Natalia García, Antonio Jesús Fernández Rodríguez, Francisco Martín León, Pedro Reis Costa, Lucía Soliño, Susana Margarida Rodrigues, Alexandra Silva, Lia Godinho, António Marques, Popi Kanari, Georgios Stavroulakis, Georgios Papageorgiou, Elina Chrysanthou, Katerina Aligizaki, Iliana Nikolopoulou, Agoritsa Kaliwra, José Manuel Leão, Pablo Estévez, David Castro, C. Barrios, Philipp Heß, Manoëlla Sibat,
The EuroCigua project main objective is to characterize the risk of Ciguatera Poisoning (CP) in Europe including several specific objectives: to determine the incidence of ciguatera in Europe and the epidemiological characteristics of cases; to assess the presence of ciguatoxin in food and the environment in Europe and to develop and validate methods for the detection, quantification and confirmation of the presence of ciguatoxin contaminated specimens. This report compiles the activities carried ...
Tópico(s): Neuroscience of respiration and sleep
2021 - European Food Safety Authority | EFSA Supporting Publications
Ivo E. Sampaio‐Dias, Ana Reis-Mendes, Vera Marisa Costa, Xerardo Garcı́a-Mera, José Brea, Marı́a Isabel Loza, Beatriz L. Pires-Lima, Cristina Alcoholado, Manuel Algarra, José E. Rodríguez‐Borges,
The control of Parkinson's disease (PD) is challenged by the motor and non-motor fluctuations as well as dyskinesias associated with levodopa long-term therapy. As such, pharmacological alternatives to reduce the reliance on this drug are needed. Melanostatin (MIF-1), a positive allosteric modulator (PAM) of D2 receptors (D2R), is being explored as a novel pharmacological approach focused on D2R potentiation. In this work, 3-furoic acid (3-Fu) was successfully employed as an l-proline (Pro) surrogate, ...
Tópico(s): Chemical Synthesis and Analysis
2021 - American Chemical Society | Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Luan José Lopes Teles, Felipe J. Aidar, Dihogo Gama de Matos, Anderson Carlos Marçal, Paulo Francisco de Almeida‐Neto, Eduardo Borba Neves, Osvaldo Costa Moreira, Frederico Ribeiro Neto, Nuno Garrido, José Vilaça‐Alves, Alfonso López Díaz de Durana, Filipe Manuel Clemente, Ian Jeffreys, Breno Guilherme de Araújo Tinôco Cabral, Víctor Machado Reis,
In Paralympic powerlifting (PP), athletes with and without spinal cord injury (SCI) compete in the same category. Athletes with SCI may be at a disadvantage in relation to the production of muscle strength and the execution of motor techniques.To analyze the indicators force, dynamic and static, at different intensities, on performance in athletes with and without SCI.The sample was composed of two groups of PP athletes: SCI (30.57 ± 4.20 years) and other deficiencies (OD; 25.67 ± 4.52 years). Athletes ...
Tópico(s): Sports injuries and prevention
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Manuel A.V. Ribeiro da Silva, Ana I.M.C. Lobo Ferreira, Ana Filipa L.O.M. Santos, Cristiana M.A. Ferreira, D. Barros, Joana Reis, José C. S. Costa, Maria Miguel G. Calvinho, Sónia Rocha, Sónia P. Pinto, Sonia Freire, Suzete Almeida, Vanessa Guimarães, Vasco N.M. Almeida,
Abstract The standard (p∘ = 0.1 MPa) molar enthalpies of formation, in the crystalline state, of 1,5-diaminonaphthalene and 1,8-diaminonaphthalene were derived from the standard molar energies of combustion, in oxygen, at T = 298.15 K, measured by static-bomb combustion calorimetry. The Knudsen mass-loss effusion technique was used to measure the dependence of the vapour pressure of the solid isomers of diaminonaphthalene with the temperature, from which the standard molar enthalpies of sublimation ...
Tópico(s): Phase Equilibria and Thermodynamics
2009 - Elsevier BV | The Journal of Chemical Thermodynamics
Produção Nacional
Revisado por pares
Danielle Pessôa-Pereira, Adriane Feijó Evangelista, Rhafaela Lima Causin, René Aloísio da Costa Vieira, Lucas Faria Abrahão-Machado, Iara Viana Vidigal Santana, Vinícius Duval da Silva, Karen Cristina Borba Souza, Renato José da Silva Oliveira, Gabriela Carvalho Fernandes, Rui Manuel Reis, Edenir Inêz Palmero, Márcia Maria Chiquitelli Marques,
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequently reported in sporadic breast cancers, but few studies have focused on profiling hereditary breast cancers. In this study, we aimed to identify specific miRNA signatures in hereditary breast tumors and to compare with sporadic breast cancer and normal breast tissues.Global miRNA expression ...
Tópico(s): CRISPR and Genetic Engineering
2020 - BioMed Central | BMC Cancer
Produção Nacional
Revisado por pares
Rodrigo Sampaio Chiarantano, Fabiana de Lima Vazquez, Alexánder Franco, Larissa Cristina Ferreira, Maraisa Costa, Thais Talarico, Ângela Neves Oliveira, José Elias Miziara, Edmundo Carvalho Mauad, Eduardo Caetano da Silva, Luís Marcelo Ventura, Raphael Luiz Haikel, Letícia Ferro Leal, Rui Manuel Reis,
Lung cancer is the deadliest cancer worldwide and in Brazil. Despite strong evidence, lung cancer screening by low-dose computed tomography (LDCT) in high-risk individuals is far from a reality in many countries, particularly in Brazil. Brazil has a universal public health system marked with important inequalities. One affordable strategy to increase the coverage of resources is to use mobile units.To describe the implementation and results of an innovative lung cancer prevention program that integrates ...
Tópico(s): Lung Cancer Research Studies
2022 - SAGE Publishing | Cancer Control
Produção Nacional
Revisado por pares
Felipe J. Aidar, Filipe Manuel Clemente, Dihogo Gama de Matos, Anderson Carlos Marçal, Raphael Fabrício de Souza, Osvaldo Costa Moreira, Paulo Francisco de Almeida‐Neto, José Vilaça‐Alves, Nuno Garrido, Jymmys Lopes dos Santos, Ian Jeffreys, Frederico Ribeiro Neto, Víctor Machado Reis, Breno Guilherme de Araújo Tinôco Cabral, Thomas Rosemann, Beat Knechtle,
Background: The sticking region is considered an intervening factor in the performance of the bench press with high loads. Objective: To evaluate the strength indicators in the sticking point region in Powerlifting Paralympic athletes. Methods: Twelve Brazilian Powerlifting Paralympic athletes performed maximum isometric force (MIF), rate of force development (RFD), time at MIF, velocity, dynamic time in sticking, and surface electromyography in several distances from the bar to the chest. Results: ...
Tópico(s): Sports Performance and Training
2021 - Multidisciplinary Digital Publishing Institute | Journal of Functional Morphology and Kinesiology
Produção Nacional
Revisado por pares
Raquel Spinassé Dettogni, Elaine Stur, Ana Carolina Laus, René Aloísio da Costa Vieira, Márcia Maria Chiquitelli Marques, Iara Viana Vidigal Santana, José Zago Pulido, Laura Fregonassi Ribeiro, Narelle de Jesus Parmanhani, Lidiane Pignaton Agostini, Raquel Reis, Eldamária de Vargas Wolfgramm dos Santos, Lyvia Neves Rebello Alves, Fernanda Mariano Garcia, Jéssica Aflávio Santos, Diego do Prado Ventorim, Rui Manuel Reis, Iúri Drumond Louro,
Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for more adequate patient treatment. We aimed to identify potential biomarkers that can predict invasiveness risk.In this epithelial cell-based study archival formalin-fixed paraffin-embedded blocks from six patients diagnosed with invasive lesions (pure invasive ductal carcinoma), six with in-situ ...
Tópico(s): Hedgehog Signaling Pathway Studies
2020 - BioMed Central | BMC Cancer
Bruno M. Costa, Marta Viana‐Pereira, Ricardo Ferreira Fernandes, Sandra Costa, Paulo Linhares, Ruí Vaz, Céline Pinheiro, Jorge Lima, Paula Soares, Ana Silva, Fernando Pardal, Júlia Amorim, Rui Nabiço, Rui Almeida, Carlos Alegria, Manuel Melo Pires, Célia Pinheiro, Ernesto Carvalho, Pedro Oliveira, José Manuel Lopes, Rui Manuel Reis,
Abstract Background: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, −216G/T and −191C/A, and a polymorphic (CA)n microsatellite sequence in intron 1. We aimed to elucidate the roles of these EGFR polymorphisms in glioma susceptibility and prognosis. Methods: ...
Tópico(s): HER2/EGFR in Cancer Research
2011 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Produção Nacional
Revisado por pares
Marcelo de Aquino Resende, Felipe J. Aidar, Roberta Barreto Vasconcelos Resende, Gracielle Costa Reis, Layanne de Oliveira Barros, Dihogo Gama de Matos, Anderson Carlos Marçal, Paulo Francisco de Almeida‐Neto, Alfonso López Díaz de Durana, María Merino-Fernández, José Vilaça‐Alves, Breno Guilherme de Araújo Tinôco Cabral, Eduardo Borba Neves, Víctor Machado Reis, Filipe Manuel Clemente, Nuno Garrido,
(1) Background: the present study aimed to evaluate the effect of different types of warm-ups on the strength and skin temperature of Paralympic powerlifting athletes. (2) Methods: the participants were 15 male Paralympic powerlifting athletes. The effects of three different types of warm-up (without warm-up (WW), traditional warm-up (TW), or stretching warm-up (SW)) were analyzed on static and dynamic strength tests as well as in the skin temperature, which was monitored by thermal imaging. (3) Results: ...
Tópico(s): Sports Performance and Training
2021 - Multidisciplinary Digital Publishing Institute | Healthcare