... y Morán. Included are letters from his father, Manuel Ignacio Moreno, and his uncle, José Ignacio Moreno, and messages that mention Miguel's ...
1837 - Gale Group | World Scholar Latin America
Luis Castilla‐Guerra, Antonio Espino-Montoro, María del Carmen Fernández Moreno, José Manuel López‐Chozas, María Dolores Jimérnez,
... and Antonio Espino-Montoro María del Carmen Fernandez Moreno José Manuel López-Chozas María Dolores Jimérnez Luis Castilla-GuerraLuis ... María del Carmen Fernandez MorenoMaría del Carmen Fernandez Moreno Department of Neurology, Hospital de Valme, Seville, Spain José Manuel López-ChozasJosé Manuel López-Chozas Department of Internal ...
Tópico(s): Protease and Inhibitor Mechanisms
2006 - Lippincott Williams & Wilkins | Stroke
... y Morán. Included are letters from his father, Manuel Ignacio Moreno, and his uncle, José Ignacio Moreno, and messages that mention Miguel's ...
1837 - Gale Group | World Scholar Latin America
José Manuel Muñoz–Redondo, Belén Puertas, Emma Cantos‐Villar, María Jesús Jiménez‐Hierro, María Carbú, Carlos Garrido, María José Ruiz‐Moreno, José Manuel Moreno‐Rojas,
Controlled inoculations of non-Saccharomyces yeasts are becoming increasingly used to produce high-quality wines due to their enological potential. In this study, we evaluated the impact of sequential inoculation with the commercial non-Saccharomyces yeasts (Torulaspora delbrueckii and Metschnikowia pulcherrima) in combination with Saccharomyces cerevisiae on the chemical and sensory profile of rosé wines. Sequential inoculation with T. delbrueckii produced wines with an overall reduction in esters, ...
Tópico(s): Sensory Analysis and Statistical Methods
2021 - American Chemical Society | Journal of Agricultural and Food Chemistry
Francisco Julián Cuevas, Gema Pereira‐Caro, José Manuel Moreno‐Rojas, José Manuel Muñoz–Redondo, María José Ruiz‐Moreno,
This study aims to develop a robust chemometric approach to make it possible to authenticate European premium organic orange juices. The metabolomic fingerprinting and the volatile profile of commercial orange juices were analyzed by HPLC-HR-MS and HS-SPME-GC-MS. These data were used for authentication (classification of orange juices) purposes, using principal component analysis, hierarchical cluster analysis and partial least squares discriminant analysis, which provided acceptable results. Some ...
Tópico(s): Advanced Chemical Sensor Technologies
2017 - Elsevier BV | Food Control
María José Ruiz‐Moreno, José Manuel Muñoz–Redondo, Francisco Julián Cuevas, Almudena Marrufo‐Curtido, Juan Manuel Bello León, Pilar Ramírez, José Manuel Moreno‐Rojas,
The influence of pre-fermentative maceration and ageing factors on the ester profiles of Pedro Ximenez sparkling wines was evaluated. The pre-fermentative maceration consisted of the skin-maceration of musts at 10°C for 6h. The sparkling wines were produced following the Champenoise method. Samples were monitored at 3, 6 and 9months of ageing on lees. Sparkling wines with pre-fermentative maceration displayed higher contents of ethyl esters of branched acids and cinnamates. Meanwhile, those without ...
Tópico(s): Wine Industry and Tourism
2017 - Elsevier BV | Food Chemistry
Vanessa Cardeñosa, Amadeo Gironés‐Vilaplana, J. L. Muriel, Diego A. Moreno, José Manuel Moreno‐Rojas,
Demand for and availability of blueberries has increased substantially over recent years, driven in part by their health-promoting properties. Three blueberry varieties ('Rocío', V2, and V3) were grown under two cultivation systems (open-field and plastic tunnels) and subjected to two irrigations regimes (100% and 80% of crop evapotranspiration) in two consecutive years (2011-2012). They were evaluated for their phytochemical composition and antioxidant capacity. Genotype influenced the antioxidant capacity ...
Tópico(s): Postharvest Quality and Shelf Life Management
2016 - Elsevier BV | Food Chemistry
Susana Redecilla Ferreiro, Ana Moráis López, José Manuel Moreno Villares, Susana Redecilla Ferreiro, Ana Moráis López, José Manuel Moreno Villares, Rosaura Leis, Juan José Díaz, Miguel Sáenz de Pipaón, Luis Blesa, Cristina Campoy, Miguel Ángel Sanjosé, Mercedes Gil‐Campos, Susana Ares Segura,
In the last few years, there are an increased number of families following a vegetarian diet, including their children. In order to guarantee child heath, paediatricians need to know the characteristics of this diet and the main foods that are used. There are few data on the medium and long-term health outcomes when removing all animal foods from the child's diet, especially at younger ages. Nevertheless, new tools have recently become available to facilitate following a vegetarian diet and decreasing ...
Tópico(s): Diet and metabolism studies
2019 - Elsevier BV | Anales de Pediatría
M. Vasconi, Alexander Lopez, Cristina Galimberti, José Manuel Moreno‐Rojas, José Manuel Muñoz Redondo, F. Bellagamba, V.M. Moretti,
We determined fatty acid profile and protein carbon and nitrogen isotopic composition in muscle of wild and farmed eels, in order to discriminate the geographical origin of fish and their dietary habits. The samples were divided into groups according to the farm origin (Italy, Denmark and Netherland), the market size (capitoni and buratelli) and the farming system (pond, RAS, lagoon and wild). Biometric measurements, proximate composition analysis (moisture, ash, lipid and protein content), fatty acids ...
Tópico(s): Fish Biology and Ecology Studies
2019 - Elsevier BV | Food Control
Lluís Serra‐Majem, António Raposo, Javier Aranceta Bartrina, Gregorio Varela‐Moreiras, Caomhán Logue, Hugo Laviada‐Molina, Susana Socolovsky, Carmen Pérez‐Rodrigo, Jorge Antonio Aldrete-Velasco, Eduardo Meneses Sierra, Rebeca López‐García, Adriana Ortiz‐Andrellucchi, Carmen Gómez‐Candela, Rodrigo Abreu, Erick Alexánderson, Rolando J. Álvarez‐Álvarez, Ana Luisa Álvarez Falcón, Arturo Anadón, France Bellisle, Ina Alejandra Beristain-Navarrete, Raquel Blasco Redondo, Tommaso Bochicchio, José Camolas, Fernando Cardini, Márcio Carocho, Maria do Céu Costa, Adam Drewnowski, Samuel Durán‐Agüero, Víctor Faúndes, Roxana Carla Fernández Condori, Pedro Pablo García‐Luna, J. C. Romero Garnica, Marcela González‐Gross, Carlo La Vecchia, Rosaura Leis, Ana M. López‐Sobaler, Miguel Agustín Madero, Ascensión Marcos, Luis Alfonso Mariscal Ramírez, Danika M. Martyn, Lorenza Mistura, Rafael Moreno Rojas, José Manuel Moreno Villares, José Antonio Niño-Cruz, M. Beatriz P.P. Oliveira, Nieves Palacios Gil-Antuñano, Lucía Pérez-Castells, Lourdes Ribas‐Barba, Rodolfo Rincón Pedrero, Pilar Riobó, Juan Rivera, Catarina Tinoco de Faria, Roxana Valdés‐Ramos, Elsa Vasco, Sandra N. Wac, Guillermo Wakida, Carmina Wanden-Berghe, Luis Xóchihua Díaz, Sergio Zúñiga-Guajardo, Vasiliki Pyrogianni, Sérgio Cunha Velho de Sousa,
International scientific experts in food, nutrition, dietetics, endocrinology, physical activity, paediatrics, nursing, toxicology and public health met in Lisbon on 2–4 July 2017 to develop a Consensus on the use of low- and no-calorie sweeteners (LNCS) as substitutes for sugars and other caloric sweeteners. LNCS are food additives that are broadly used as sugar substitutes to sweeten foods and beverages with the addition of fewer or no calories. They are also used in medicines, health-care products, ...
Tópico(s): Diet, Metabolism, and Disease
2018 - Multidisciplinary Digital Publishing Institute | Nutrients
Fiona MacArthur, José Luis Oncins-Martínez, Manuel Sánchez-García, Ana María Piquer Píriz,
... analysis from an experientialist perspective (by Urena Gomez-Moreno, Jose Manuel) 19. Chapter 12. Gestures, language, and what they ...
Tópico(s): Lexicography and Language Studies
2012 - John Benjamins Publishing Company | Human cognitive processing
R. Ortega Castro, Pilar Font, Carmen Castro, Jerusalem Calvo‐Gutiérrez, E. Muñoz Gomariz, Pedro Zarco, Raquel Almodóvar, J. Mulero Mendoza, Juan Carlos Torre‐Alonso, Jordi Gratacós, Xavier Roura, Rafael Ariza Ariza, Pilar Fernández Dapica, Luis Francisco Linares Ferrando, M. Elia Brito Brito, Eduardo Cuende Quintana, Carlos Vázquez Galeano, Manuel José Moreno Ramos, Eugenio Giménez Úbeda, José Carlos Rodríguez Lozano, Manuel Fernández Prada, Rubén Queiró, E. Moreno, Enrique Júdez Navarro, Antonio Juan Más, Cristina Medrano Le Quement, Enrique Ornilla, Carlos Montilla, Manuel Pujol Busquets, Teresa Clavaguera, M. Cruz Fernández-Espartero, Loreto Carmona, Eduardo Collantes‐Estévez,
Establecer las características diferenciales según el sexo y el tiempo de evolución de la enfermedad en aquellos pacientes diagnosticados de espondilitis anquilosante (EA) asistidos en consultas de reumatología de toda España, incluidos en el Registro Español de Espondiloartritis (REGISPONSER), así como la repercusión diagnóstica y terapéutica que ello conlleva. Estudio transversal y observacional de 1.514 pacientes con EA seleccionados de entre 2.367 con espondiloartritis incluidos en REGISPONSER. ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2013 - Elsevier BV | Reumatología Clínica
R. Ortega Castro, Pilar Font, Carmen Castro, Jerusalem Calvo‐Gutiérrez, E. Muñoz Gomariz, Pedro Zarco, Raquel Almodóvar, J. Mulero Mendoza, Juan Carlos Torre‐Alonso, Jordi Gratacós, Xavier Roura, Rafael Ariza Ariza, Pilar Fernández Dapica, Luis Francisco Linares Ferrando, M. Elia Brito Brito, Eduardo Cuende Quintana, Carlos Vázquez Galeano, Manuel José Moreno Ramos, Eugenio Giménez Úbeda, José Carlos Rodríguez Lozano, Manuel Fernández Prada, Rubén Queiró, E. Moreno, Enrique Júdez Navarro, Antonio Juan Más, Cristina Medrano Le Quement, Enrique Ornilla, Carlos Montilla, Manuel Pujol Busquets, Teresa Clavaguera, M. Cruz Fernández-Espartero, Loreto Carmona Ortell, Eduardo Collantes‐Estévez,
To describe the differential characteristics by gender and time since disease onset in patients diagnosed with ankylosing spondylitis (AS) attending the Spanish rheumatology clinics, including those on the “Spanish Registry of spondyloarthritis” (REGISPONSER), as well as the diagnostic and therapeutic implications that this entails. This is a transversal and observational study of 1514 patients with AS selected from 2367 spondyloarthritis cases included in REGISPONSER. For each patient, the demographics, ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2013 - Elsevier BV | Reumatología Clínica (English Edition)
José Luis Ordóñez-Díaz, Gema Pereira‐Caro, Iziar A. Ludwig, José Manuel Muñoz–Redondo, María José Ruiz‐Moreno, Alan Crozier, José Manuel Moreno‐Rojas,
The present study compared and validated two analytical methods, HPLC-HRMS, and GC–MS using MSTFA as derivatization agent, for the analysis of microbiota-derived phenolic acids and aromatic compounds accumulating in urine, collected over a 24 h period after the consumption of 500 mL of orange juice. In addition, purification procedures using SDB-L and HLB solid phase cartridges were compared when HPLC-HRMS technique was used. Both HPLC-HRMS and GC–MS methodologies were successfully validated in ...
Tópico(s): Phytochemicals and Antioxidant Activities
2018 - Elsevier BV | Journal of Chromatography A
María José Ruiz‐Moreno, Rafaela Raposo, José Manuel Moreno‐Rojas, Pilar Zafrilla, José María Cayuela, Juana Mulero, Belén Puertas, Raúl F. Guerrero, Z. Piñeiro, Francisco Girón, Emma Cantos‐Villar,
Olive oil industry produces high amounts of olive mill solid waste. These have been described as natural source of hydroxytyrosol, which shows high antioxidant and antimicrobial properties joint to health-promoting effects. In the present work, an olive mill solid waste extract dissolved in model wine was evaluated to determine its potential capacity to replace and/or reduce sulfur dioxide in winemaking. Olive oil mill extract is a potent antioxidant of biological origin. The extract resulted in ...
Tópico(s): Edible Oils Quality and Analysis
2014 - Elsevier BV | LWT
Antonio Casado‐Díaz, José Manuel Moreno‐Rojas, José Verdú Soriano, José Luís Lázaro‐Martínez, Leocadio Rodríguez‐Mañas, Isaac Túñez, Manuel La Torre, Miriam Berenguer‐Pérez, Feliciano Priego‐Capote, Gema Pereira‐Caro,
The excess of free radicals in the wound environment contributes to its stagnation during the inflammatory phase, favoring hard-to-heal wounds. Oxidative stress negatively affects cells and the extracellular matrix, hindering the healing process. In this study, we evaluated the antioxidant and wound-healing properties of a novel multifunctional amorphous hydrogel-containing Olea europaea leaf extract (OELE). Five assessments were performed: (i) phenolic compounds characterization in OELE; (ii) absolute ...
Tópico(s): Phytochemicals and Antioxidant Activities
2022 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Alicia Moreno-Ortega, Gema Pereira‐Caro, José Luis Ordóñez-Díaz, José Manuel Muñoz–Redondo, Rafael Moreno Rojas, Jesús Pérez Aparicio, José Manuel Moreno‐Rojas,
This study aims to investigate whether the heat treatment applied during the production of black onion, a novel derived product made from fresh onion, produces changes in the content of flavonoids, organosulfur compounds, organic acids, water soluble sugars and amino acids in three onion varieties ('Shallot', 'Chata' and 'Echalion'). The total flavonoid content decreased up to 12-fold in black onions compared with fresh onions while the quantities of isoalliin, the main organosulfur compound in black ...
Tópico(s): Phytochemistry and biological activities of Ficus species
2019 - Elsevier BV | Food Chemistry
Francisco Julián Cuevas, Gema Pereira‐Caro, José Manuel Muñoz–Redondo, María José Ruiz‐Moreno, José Carlos Montenegro, José Manuel Moreno‐Rojas,
Spain is the second largest European producer of oranges and the fourth in the world. Moreover, in Andalusia, the land dedicated to organic farming of oranges has doubled in the last decade (2006–2016). The great challenge in the organic farming sector is to find a reliable analytical technique (or a set thereof) to verify that the method of production followed the organic production guidelines. A new methodology based on stable isotopes, (poly)phenol profiling and conventional quality data in the ...
Tópico(s): Advanced Chemical Sensor Technologies
2019 - Elsevier BV | Food Control
Francisco J. Hernández-Walias, Esther Vázquez, Yolanda M. Pacheco, José M. Rodríguez-Fernández, Maria Jesús Pérez‐Elías, Fernando Dronda, José L. Casado, Ana Moreno, José Manuel Hermida, Carmen Quereda, Asunción Hernando, Francisco Tejerina, Víctor Asensi, Marı́a José Galindo, Manuel Leal, Santiago Moreno, Alejandro Vallejo,
The incidence of classical Hodgkin lymphoma (cHL) in the HIV-1 setting has increased 5–25-fold compared to that observed in the general population. This study aimed to determine whether selected micro RNAs (miRs) and other soluble biomarkers and cellular subsets are dysregulated in cHL and could be used as biomarkers. This was a retrospective and longitudinal matched case-control study of 111 Caucasian, HIV-1-infected adult individuals, including 37 individuals with cHL and 74 with no type of cancer. ...
Tópico(s): Extracellular vesicles in disease
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Efrén Pérez‐Santín, Raquel Rodríguez‐Solana, Mariano González García, Marı́a del Mar Garcı́a-Suárez, Gerardo Diaz, María Dolores Cima‐Cabal, José Manuel Moreno‐Rojas, José Ignacio López Sánchez,
Abstract The use and production of chemical compounds are subjected to strong legislative pressure. Chemical toxicity and adverse effects derived from exposure to chemicals are key regulatory aspects for a multitude of industries, such as chemical, pharmaceutical, or food, due to direct harm to humans, animals, plants, or the environment. Simultaneously, there are growing demands on the authorities to replace traditional in vivo toxicity tests carried out on laboratory animals (e.g., European Union ...
Tópico(s): Pesticide Residue Analysis and Safety
2021 - Wiley | Wiley Interdisciplinary Reviews Computational Molecular Science
Angélica Quintero‐Flórez, Gema Pereira‐Caro, Cristina Sánchez-Quezada, José Manuel Moreno‐Rojas, José J. Gaforio, Antonio Jiménez, Gabriel Beltrán,
Tópico(s): Essential Oils and Antimicrobial Activity
2017 - Springer Science+Business Media | European Journal of Nutrition
Isabel Fradejas, José Miguel Rubio, Ariadna Martín-Díaz, Juan María Herrero‐Martínez, José Manuel Ruiz‐Giardín, Gerardo Rojo-Marcos, María Velasco, María Calderón‐Moreno, José Manuel Azcona, F. Merino, Belén Andrés Olmo, María Espinosa, María L. Cuadrado, Esther González‐Monte, Jerónimo Jaqueti Aroca, Juan Cuadros‐González, Carolina Campelo, Alberto Delgado‐Iribarren, Pablo Martı́n-Rabadán, Concepción García García, María Ángeles Martín-Laso, Beatriz Valle Borrego, María Coral García, Manuel Lizasoaín, Ana Pérez‐Ayala,
The importance of submicroscopic malaria infections in high-transmission areas could contribute to maintain the parasite cycle. Regarding non-endemic areas, its importance remains barely understood because parasitaemia in these afebrile patients is usually below the detection limits for microscopy, hence molecular techniques are often needed for its diagnosis. In addition to this, the lack of standardized protocols for the screening of submicroscopic malaria in immigrants from endemic areas may ...
Tópico(s): Mosquito-borne diseases and control
2019 - BioMed Central | Malaria Journal
José Manuel Muñoz–Redondo, María José Ruiz‐Moreno, Belén Puertas, Emma Cantos‐Villar, José Manuel Moreno‐Rojas,
A headspace solid-phase microextraction coupled to gas-chromatography and mass spectrometry (HS-SPME-GC-MS) was developed and validated for the determination of 26 terpenes in sparkling wines. The use of a Box-Behnken experimental design, together with the desirability function D, allowed the extraction conditions of the method to be optimized. The optimal extraction conditions were found at a dilution ratio of 2:3, the addition of 3.5 g of NaCl, an extraction temperature of 46 °C and an extraction ...
Tópico(s): Tea Polyphenols and Effects
2019 - Elsevier BV | Talanta
Ralf Reilmann, Karen E. Anderson, Andrew Feigin, Sarah J. Tabrizi, Blair R. Leavitt, Julie C. Stout, Paola Piccini, Robin Schubert, Pippa S. Loupe, Anna Teige Wickenberg, Beth Borowsky, Gail Rynkowski, Rita Volkinshtein, Thomas Li, Juha‐Matti Savola, Michael R. Hayden, Mark Forrest Gordon, Mark Guttman, Lynn A. Raymond, Tilak Mendis, Oksana Suchowersky, Jody Corey‐Bloom, Michael D. Geschwind, Frederick J. Marshall, Karen Marder, Martha Nance, Brad A. Racette, Jee Bang, Victoria Segro, Katherine E. McDonell, John Kamholz, Mark S. LeDoux, Juan Sanchez‐Ramos, Giuseppe Demichele, Caterina Mariotti, Ferdinando Squitieri, Paola Soliveri, Pietro Cortelli, José Esteban Muñoz García, J. Kulisevsky Bojarski, José Luis López-Sendón, Koldo Berganzo Corrales, Esther Cubo, José Manuel García Moreno, Michael Orth, Josef Priller, Carsten Saft, A. Weindl, Jürgen Winkler, David Craufurd, Z Miedzybrodzka, Hugh Rickards, Rhys Richard Davies, Nayana Lahiri, Deborah Ruddy, Suresh K Komati, Oliver William John Quarrell, Leonor Correira Guedes, Raymund A.C. Roos, Zuleykha Zalyalova, С. Н. Иллариошкин, А В Густов, Jiří Klempíř,
Summary Background Laquinimod modulates CNS inflammatory pathways thought to be involved in the pathology of Huntington's disease. Studies with laquinimod in transgenic rodent models of Huntington's disease suggested improvements in motor function, reduction of brain volume loss, and prolonged survival. We aimed to evaluate the safety and efficacy of laquinimod in improving motor function and reducing caudate volume loss in patients with Huntington's disease. Methods LEGATO-HD was a multicentre, double- ...
Tópico(s): Hereditary Neurological Disorders
2024 - Elsevier BV | The Lancet Neurology
Francisco Julián Cuevas, José Manuel Moreno‐Rojas, María José Ruiz‐Moreno,
A targeted approach using HS-SPME-GC-MS was performed to compare flavour compounds of 'Navelina' and 'Salustiana' orange cultivars from organic and conventional management systems. Both varieties of conventional oranges showed higher content of ester compounds. On the other hand, higher content of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates) and some terpenoids were found in the organic samples. Furthermore, the partial least square discriminant analysis ( ...
Tópico(s): Advanced Chemical Sensor Technologies
2016 - Elsevier BV | Food Chemistry
José Manuel Moreno Villares, María José Galiano Segovia,
Title: The family meal: somewhat more than eating together The family can exert a strong influence on children’s diet and eating behaviors, which, in turn, may have an impact on their weight status. Since the dawn of time, the dining table has been the nexus of family interaction. The simple act of sharing meals solidifies the family identity and family ties by modeling a wide range of learned behavioural patterns. One of the groups most affected in this respect are adolescents. Researchers have ...
Tópico(s): Food, Nutrition, and Cultural Practices
2006 - Mayo | Acta pediátrica española/Acta pediátrica española
Alicia Moreno-Ortega, Gema Pereira‐Caro, José Luis Ordóñez-Díaz, Rafael Moreno Rojas, Víctor Ortiz-Somovilla, José Manuel Moreno‐Rojas,
Numerous studies have reported health benefits associated with the consumption of fresh and black garlic, which are characterized by the presence of polyphenols and organosulfur compounds (OS). This study aims to analyze the bioaccessibility of the bioactive compounds in fresh and black garlic after in vitro gastrointestinal digestion by monitoring the individual profile of these compounds by ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS). Polyphenols ...
Tópico(s): Phytase and its Applications
2020 - Multidisciplinary Digital Publishing Institute | Foods
Manuel José Moreno Ramos, Carlos Sánchez‐Piedra, Olga Martínez González, Carlos Rodríguez‐Lozano, Carolina Pérez-García, Mercedes Freire, Cristina Campos, Rafael Cáliz-Cáliz, Jerusalem Calvo‐Gutiérrez, J. M. Blanco-Madrigal, Ana Pérez-Gómez, María José Moreno, L. Linares, Fernando Sánchez‐Alonso, C. Sastré, Isabel Castrejón,
Rheumatic diseases are extensively managed with biological disease-modifying antirheumatic drugs (bDMARDs), but a notable proportion of patients withdraw in the long term because of lack of effectiveness, adverse events, or the patient's decision. The present real-world analysis showed the effectiveness, retention, and safety data collected in the Spanish BIOBADASER registry for patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA, including ankylosing spondylitis (AS) and non- ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2022 - Adis, Springer Healthcare | Rheumatology and Therapy
Xavier Juanola, Manuel José Moreno Ramos, Joaquín Belzunegui, Cristina Fernández‐Carballido, Jordi Gratacós,
Axial spondyloarthritis is a chronic inflammatory rheumatic disease that affects the axial skeleton and causes severe pain and disability. It may be also associated with extra-articular manifestations. Early diagnosis and appropriate treatment can reduce the severity of the disease and the risk of progression. The biological disease-modifying antirheumatic drugs (bDMARDs) tumor necrosis factor alpha (TNFα) inhibitors (TNFi) and the anti-interleukin (IL)-17A antibodies secukinumab and ixekizumab are ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2022 - Adis, Springer Healthcare | Advances in Therapy
Carlos Sánchez‐Piedra, Diana Sueiro-Delgado, Javier García‐González, Inmaculada Ros‐Vilamajó, Águeda Prior-Español, Manuel José Moreno Ramos, B. García-Magallón, Jerusalem Calvo‐Gutiérrez, Y. Perez-Vera, R. Martín-Doménech, Dolores Ruiz‐Montesino, Paloma Vela, Lorena Expósito, Fernando Sánchez‐Alonso, Enrique González‐Dávila, Federico Díaz‐González,
The better understanding of the safety of biologic DMARDs (bDMARDs), as well as the emergence of new bDMARDs against different therapeutic targets and biosimilars have likely influenced the use patterns of these compounds over time. The aim of this study is to assess changes in demographic characteristics, disease activity and treatment patterns in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ankylosing spondylitis (AS) who started a first- or second-line biologic between 2007 ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2021 - Nature Portfolio | Scientific Reports