Adolfo Mínguez‐Castellanos, Cristóbal Carnero Pardo, Angel G�mez-Camello, A Ortega-Moreno, Teresa Garc�a-G�mez, V. Arjona, J.M. Martín-Linares,
... for more papers by this authorJosé María Martin-Linares MD, José María Martin-Linares MD Movement Disorders Unit, Neurological Sciences ... for more papers by this authorJosé María Martin-Linares MD, José María Martin-Linares MD Movement Disorders Unit, Neurological Sciences Institute, Department ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
1999 - Wiley | Movement Disorders
L. Simón, Roberto Pastor‐Barriuso, Elena Boldo, Rafael Fernández-Cuenca, Cristina Ortíz, Cristina Pérez-Linares, María Medrano, Iñaki Galán,
... Elena Boldo, Rafael Fernández-Cuenca, Cristina Ortiz, Cristina Linares, María José Medrano, Iñaki Galán; Smoke-Free Legislation in Spain ...
Tópico(s): Injury Epidemiology and Prevention
2017 - American Academy of Pediatrics | PEDIATRICS
José Ignacio Linares, María José Montes, Alexis Cantizano, Consuelo Sánchez,
Power tower concentrating solar plants with thermal energy storage will play a key role in the transition to a low carbon scenario, thanks to be a dispatchable renewable energy system. The ternary MgCl2/KCl/NaCl salt appears as one of the most promising due to its lower melting point, higher heat capacity, lower cost and stability up to 800 °C. A cavity-type receiver has been selected because minimizes radiation heat loss at high working temperatures, compared to an external-type receiver, since ...
Tópico(s): Thermal Radiation and Cooling Technologies
2020 - Elsevier BV | Applied Energy
Ana Alastruey‐Izquierdo, Laura Alcázar‐Fuoli, Olga Rivero-Menéndez, Josefina Ayats, Carmen Castro, Julio García‐Rodríguez, Lidia Goterris-Bonet, Elisa Ibáñez-Martínez, María José Linares-Sicilia, María Teresa Martín-Gómez, Estrella Martín‐Mazuelos, Teresa Peláez, Javier Pemán, Antonio Rezusta, Susana Rojo‐Alba, Rocío Tejero, Diego Vicente Anza, Jesús Viñuelas, María Soledad Zapico, Manuel Cuenca‐Estrella,
Antifungal resistance is increasing by the emergence of intrinsically resistant species and by the development of secondary resistance in susceptible species. A previous study performed in Spain revealed levels of azole resistance in molds of between 10 and 12.7%, but secondary resistance in Aspergillus fumigatus was not detected. We used itraconazole (ITZ)-supplemented medium to select resistant strains. A total of 500 plates supplemented with 2 mg/liter of ITZ were sent to 10 Spanish tertiary hospitals, ...
Tópico(s): Fungal Infections and Studies
2018 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Juan Gómez-Luna, José María González-Linares, José Ignacio Benavides Benítez, Nicolás Guil,
GPU application implementations using scatter approaches will fall into write contention due to atomic updates of output elements, if these result from more than one input element. Colliding threads will be serialized, seriously harming performance. Dealing with these issues requires a proper understanding of the behavior of the scratchpad or shared memory under conflicting accesses caused by concurrent threads. Thus, this paper presents an exhaustive microbenchmark-based analysis of atomic additions ...
Tópico(s): Machine Learning in Materials Science
2013 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Parallel and Distributed Systems
Javier Pemán, Rafael Cantón, María José Linares-Sicilia, Eva María Roselló, Núria Borrell, María Teresa Ruiz-Pérez-de-Pipaon, Jesús Guinea, Julio Bobes, Aurelio Porras, Ana García-Tapia, Luisa Pérez-del-Molino, A Martínez Suárez, Julia Alcoba-Flórez, María Inmaculada García‐García,
Data on fungemia epidemiology and antifungal susceptibility of isolates from children are scarce, leading frequently to pediatric empirical treatment based on available adult data. The present study was designed to update the epidemiological, mycological, and in vitro susceptibility data on fungal isolates from children with fungemia in Spain. All fungemia episodes were identified prospectively by blood culture over 13 months at 30 hospitals. Tests of susceptibility to amphotericin B, flucytosine, ...
Tópico(s): Infections and bacterial resistance
2011 - American Society for Microbiology | Journal of Clinical Microbiology
Jèssica Latorre, Francisco Ortega, Laura Liñares‐Pose, José María Moreno‐Navarrete, Aina Lluch, Ferran Comas, Núria Oliveras‐Cañellas, Wifredo Ricart, Marcus Höring, You Zhou, Gerhard Liebisch, P.A. Nidhina Haridas, Vesa M. Olkkonen, Miguel López, José Manuel Fernández‐Real,
BackgroundWhile the impact of metformin in hepatocytes leads to fatty acid (FA) oxidation and decreased lipogenesis, hepatic microRNAs (miRNAs) have been associated with fat overload and impaired metabolism, contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD).MethodsWe investigated the expression of hundreds of miRNAs in primary hepatocytes challenged by compounds modulating steatosis, palmitic acid and compound C (as inducers), and metformin (as an inhibitor). Then, additional ...
Tópico(s): Adipose Tissue and Metabolism
2020 - Elsevier BV | EBioMedicine
Aurelio Tobı́as, Patricia García de Olalla, Cristina Linares, María José Bleda, Joan A. Caylà, Julio Díaz,
Tópico(s): Air Quality and Health Impacts
2009 - Springer Science+Business Media | International Journal of Biometeorology
Carmen Santín Vilariño, Esperanza Torrico Linares, María José López, Consuelo Revilla Delgado,
The objective of the present investigation is to describe the frequency and distribution of behaviors, attitudes and knowledge about the contraceptive methods and its relationship with behaviors of risk of transmission of illnesses. For it was evaluated it a sample constituted by 483 youths of different escolarizacion levels, with ages understood between 14 and 20 years, to those that a questionnaire was administered that it picks up information about its level of knowledge it has more than enough ...
Tópico(s): Medicine, History, and Philosophy
2003 - Servicio de Publicaciones | Anales de Psicología
Carolina Torres, Ana Linares, María José Alejandre, Rogelio Palomino‐Morales, Octavio Caba, José Prados, Antonia Aránega, Juan Ramón Delgado, Antonio Irigoyen López, Joaquina Martínez-Galán, Francisco Ortuño, Ignacio Rojas, Sonia Perales,
The overall survival of patients with pancreatic ductal adenocarcinoma is extremely low. Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in patients with pancreatic cancer and ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2015 - Hindawi Publishing Corporation | BioMed Research International
S. Tejada, Pilar Baca, Carmen María Ferrer‐Luque, Matilde Ruíz-Linares, María José Valderrama, María Teresa Arias‐Moliz,
To determine the free available chlorine of 2.5% sodium hypochlorite (NaOCl) alone and combined with 9% etidronic acid (HEDP) in the presence of inhibitors, organic tissue and organic tissue plus dentine debris; to evaluate the influence of dentine debris on the tissue-dissolving capacity of both NaOCl solutions; and to determine the antimicrobial action of these solutions when in contact with organic tissue and organic tissue plus dentine debris.The available chlorine of the solutions over time in ...
Tópico(s): Oral microbiology and periodontitis research
2018 - Wiley | International Endodontic Journal
Guillermo Quindós, Katherine Miranda-Cadena, Rosario San-Millán, Katyna Borroto–Esoda, Rafael Cantón, María José Linares-Sicilia, Axel Hamprecht, Isabel Montesinos, Anna Maria Tortorano, Anna Prigitano, Matxalen Vidal‐García, Cristina Marcos‐Arias, Andrea Guridi, F Sánchez, Jesús Machuca-Bárcena, Manuel Rodríguez‐Iglesias, Estrella Martín‐Mazuelos, Carmen Castro-Méndez, Leire López-Soria, Alba Ruiz‐Gaitán, Marcelo Ernesto Fernández-Rivero, Damaris Lorenzo-Gutiérrez, Javier Capilla, Antonio Rezusta, Javier Pemán, Josep Guarro, Joana B. Pereira, Célia Pais, Orazio Romeo, Guillermo Ezpeleta, Nerea Jauregizar, David Angulo, Elena Eraso,
Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis.The aim of this study was to assess the in vitro activity of ibrexafungerp and comparators against a collection of 434 European blood isolates of Candida.Ibrexafungerp, caspofungin, fluconazole, and micafungin minimum inhibitory concentrations (MICs) were collected from 12 European laboratories for 434 blood isolates, including 163 Candida albicans, ...
Tópico(s): Fungal Biology and Applications
2022 - Frontiers Media | Frontiers in Cellular and Infection Microbiology
Produção Nacional
Revisado por pares
Ana Espinel‐Ingroff, John Turnidge, Ana Alastruey‐Izquierdo, Éric Dannaoui, Guillermo García‐Effrón, Jesús Guinea, Sarah Kidd, Teresa Peláez, Maurizio Sanguinetti, Joseph Meletiadis, Françoise Botterel, Beatriz Bustamante, Yee‐Chun Chen, Arunaloke Chakrabarti, Anuradha Chowdhary, Erja Chryssanthou, Susana Córdoba, Gloria M. González, Josep Guarro, Elizabeth M. Johnson, Julianne V. Kus, Cornelia Lass‐Flörl, María José Linares-Sicilia, Estrella Martín‐Mazuelos, C. E. Negri, Michael A. Pfaller, Anna Maria Tortorano,
Estimating epidemiological cutoff endpoints (ECVs/ECOFFS) may be hindered by the overlap of MICs for mutant and nonmutant strains (strains harboring or not harboring mutations, respectively). Posaconazole MIC distributions for the Aspergillus fumigatus species complex were collected from 26 laboratories (in Australia, Canada, Europe, India, South and North America, and Taiwan) and published studies. Distributions that fulfilled CLSI criteria were pooled and ECVs were estimated. The sensitivity of three ...
Tópico(s): Fungal Infections and Studies
2018 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Elena Pérez‐Nadales, Ana Alastruey‐Izquierdo, María José Linares-Sicilia, Juan Carlos Soto-Debrán, Edson Abdala, Julio García‐Rodríguez, Miguel Montejo, Patricia Muñóz, Miguel Salavert, Antonio Rezusta, Maite Ruiz Pérez de Pipaón, Lucrecia Yáñez, Esperanza Merino, María Isolina Campos-Herrero, José María Costa-Mateo, Jesús Fortün, Tomás García‐Lozano, Carolina García‐Vidal, Mario Fernández‐Ruiz, F Sánchez, Carmen Castro-Méndez, Inmaculada Guerrero-Lozano, Pere Soler‐Palacín, José María Aguado, Luis Martínez-Martínez, Julián Torre-Cisneros, Márcio Nucci,
Abstract Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000–2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000–2009 to 0.22 cases per 100,000 admissions in 2010–2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic ...
Tópico(s): Plant Pathogens and Fungal Diseases
2021 - Centers for Disease Control and Prevention | Emerging infectious diseases
Marta Maycas, María Teresa Portolés, María Concepción Matesanz, Irene Buendía, Javier Linares, María José Feito, Daniel Arcos, Maria Vallet‐Regí, Lilian I. Plotkin, Pedro Esbrit, Arancha R. Gortázar,
Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte-driven bone formation. We aimed to evaluate the interaction of acute exposure (24 h) to high glucose (HG) with both the pro-survival effect conferred to osteocytic MLO-Y4 cells and osteoblastic MC3T3-E1 cells by mechanical stimulation and the interaction of these cells with osteoclast precursor RAW264.7 cells. We found that 24 h of HG (25 mM) pre-exposure prevented both cell survival and ERK and β-catenin ...
Tópico(s): Bone health and osteoporosis research
2017 - Wiley | Journal of Cellular Physiology
Produção Nacional
Revisado por pares
Ana Espinel‐Ingroff, John Turnidge, Ana Alastruey‐Izquierdo, Françoise Botterel, Rafael Cantón, C. Castro, Yee‐Chun Chen, Yan Chen, Erja Chryssanthou, Éric Dannaoui, Guillermo García‐Effrón, Gloria M. González, Nelesh P. Govender, Jesús Guinea, Sarah Kidd, Michaela Lackner, Cornelia Lass‐Flörl, María José Linares-Sicilia, Leire López-Soria, Rindidzani E. Magobo, Teresa Peláez, Guillermo Quindós, M. A. Rodriguez-Iglesia, Maite Ruiz, F Sánchez, Maurizio Sanguinetti, Ryan K. Shields, Piotr Szweda, Anna Maria Tortorano, Nancy L. Wengenack, Simone Bramati, C. Cavanna, C. DeLuca, Maria Luisa Gelmi, Anna Grancini, Giuseppe Lombardi, Joseph Meletiadis, C. E. Negri, Marco Passera, Javier Pemán, Anna Prigitano, E. Sala, M. Tejada,
Although the Sensititre Yeast-One (SYO) and Etest methods are widely utilized, interpretive criteria are not available for triazole susceptibility testing of Candida or Aspergillus species. We collected fluconazole, itraconazole, posaconazole, and voriconazole SYO and Etest MICs from 39 laboratories representing all continents for (method/agent-dependent) 11,171 Candida albicans , 215 C. dubliniensis , 4,418 C. glabrata species complex, 157 C. guilliermondii ( Meyerozyma guilliermondii ), 676 C. krusei ( Pichia ...
Tópico(s): Fungal Infections and Studies
2018 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Adolfo Mínguez‐Castellanos, Francisco Escamilla‐Sevilla, Gary Hotton, Juan José Toledo‐Aral, A Ortega-Moreno, Simón Méndez‐Ferrer, José María Martín‐Linares, Majed J. Katati, Pablo Mir, Javier Villadiego, M. Meersmans, Miguel Pérez-Garcı́a, David J. Brooks, V. Arjona, José López‐Barneo,
Carotid body (CB) glomus cells are highly dopaminergic and express the glial cell line derived neurotrophic factor. The intrastriatal grafting of CB cell aggregates exerts neurotrophic actions on nigrostriatal neurons in animal models of Parkinson disease (PD).We conducted a phase I-II clinical study to assess the feasibility, long term safety, clinical and neurochemical effects of intrastriatal CB autotransplantation in patients with PD.Thirteen patients with advanced PD underwent bilateral stereotactic ...
Tópico(s): Nerve injury and regeneration
2007 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
María José Linares Gil, Anna Esteve Gómez, Domingo Blanco Vargas, Esther Martínez Garcia, Francisco Nebot Daros, Elisenda Izquierdo Tugas, Angels Almenar Paises, Felip Pi-Siques,
Spinal anesthesia has been considered inappropriate for ambulatory surgery patients because of concern about voiding dysfunction. The purpose of this study was to analyze the relationship between voiding interval and type of surgery under spinal anesthesia with lidocaine and to identify other nonanesthetic risk factors for delayed voiding.A prospective study of 406 patients undergoing to ambulatory surgery under spinal anesthesia with lidocaine was performed. Voiding interval was defined as the ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2008 - Elsevier BV | The American Journal of Surgery
Manuel Román, María José Linares Sicilia,
A total of 126 Candida albicans strains were enzymatically evaluated by the API ZYM system. Four enzymatically based groups of C. albicans are recognized.
Tópico(s): Microbial Natural Products and Biosynthesis
1983 - American Society for Microbiology | Journal of Clinical Microbiology
Javier Pemán, Rafael Zaragoza, Guillermo Quindós, Miriam Alkorta, María Soledad Cuétara, Juan J. Camarena, Paula Ramírez, María-José Giménez, Estrella Martín‐Mazuelos, María José Linares-Sicilia, José Pontón,
Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with invasive fungal infections. Candida albicans IFA IgG has been recently commercialized for germ tube antibody detection (CAGTA). This test provides a rapid and simple diagnosis of IC (84.4% sensitivity ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2011 - BioMed Central | BMC Infectious Diseases
Rafael Salido‐Vallejo, María José Linares-Sicilia, Gloria Garnacho‐Saucedo, Marina Sánchez‐Frías, Francisco Solís-Cuesta, Josepa Gené, J.C. Moreno‐Giménez,
Phaeohyphomycosis can be caused by a number of different species, being the most common Alternaria alternata and Alternaria infectoria. The biggest risk factor for the development of the infection is immunosuppression. We present the case of a 64-year-old male renal transplant patient who came to hospital for presenting a tumour in the Achilles region which had been gradually growing in size. A skin biopsy was taken for histological study and culture of fungi and mycobacteria. Blood tests and imaging ...
Tópico(s): Infectious Diseases and Mycology
2012 - Elsevier BV | Revista Iberoamericana de Micología
Javier Pemán, Rafael Cantón, Guillermo Quindós, Elena Eraso, Julia Alcoba-Flórez, Jesús Guinea, Paloma Merino, María Teresa Ruiz-Pérez-de-Pipaon, Luisa Pérez-del-Molino, María José Linares-Sicilia, Francesc Marco, J.M. Pino García, Emiliano Martín Roselló, E. Gomez-G-de-la-Pedrosa, Núria Borrell, Aurelio Porras, Genoveva Yagüe,
To update the knowledge of the epidemiology of fungaemia episodes in Spain, the species implicated and their in vitro antifungal susceptibilities. Episodes were identified prospectively over 13 months at 44 hospitals. Molecular methods were used to determine the cryptic species inside the Candida parapsilosis and Candida glabrata complexes. Susceptibility to amphotericin B, anidulafungin, caspofungin, fluconazole, flucytosine, itraconazole, micafungin, posaconazole and voriconazole was determined ...
Tópico(s): Fungal Infections and Studies
2012 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Juan Carlos Pozo Laderas, Antonio Pontes Moreno, Carmen Pozo Salido, Juan Carlos Robles Arista, María José Linares Sicilia,
Mucormycosis is usually an acute angioinvasive infections, which leads to non-suppurative necrosis and significant tissue damage. It represents 1.6% of all the invasive fungal infections and predominates in immunosuppressed patients with risk factors. Incidence has been significantly increased even in immunocompetent patients. Due to finding a case of disseminated mucormycosis caused by Rhizomucor pusillus in a young immunocompetent patient, a systematic review was carried out of reported cases ...
Tópico(s): Ocular Infections and Treatments
2014 - Elsevier BV | Revista Iberoamericana de Micología
Ana Espinel‐Ingroff, Maiken Cavling Arendrup, Rafael Cantón, Susana Córdoba, Éric Dannaoui, Julio García‐Rodríguez, Gloria M. González, Nelesh P. Govender, Estrella Martín‐Mazuelos, Michaela Lackner, Cornelia Lass‐Flörl, María José Linares Sicilia, Manuel Rodríguez‐Iglesias, Teresa Peláez, Ryan K. Shields, Guillermo García‐Effrón, Jesús Guinea, Maurizio Sanguinetti, John Turnidge,
ABSTRACT Method-dependent Etest epidemiological cutoff values (ECVs) are not available for susceptibility testing of either Candida or Aspergillus species with amphotericin B or echinocandins. In addition, reference caspofungin MICs for Candida spp. are unreliable. Candida and Aspergillus species wild-type (WT) Etest MIC distributions (microorganisms in a species-drug combination with no detectable phenotypic resistance) were established for 4,341 Candida albicans , 113 C. dubliniensis , 1,683 C. glabrata ...
Tópico(s): Helminth infection and control
2016 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
José M. Cid, Guillaume Duvey, Gary Tresadern, Vanthea Nhem, Rocco Furnari, Philippe Cluzeau, Juan A. Vega, Ana Isabel de Lucas, Encarnación Matesanz, José Manuel Alonso Segura, María Lourdes Linares, José Ignacio Andrés, Sonia Poli, Robert Lütjens, Hassan Himogai, Jean‐Philippe Rocher, Gregor J. Macdonald, Daniel Oehlrich, Hilde Lavreysen, A. Ahnaou, Wilhelmus Drinkenburg, Claire Mackie, Andrés A. Trabanco,
The discovery and characterization of compound 48, a selective and in vivo active mGlu2 receptor positive allosteric modulator (PAM), are described. A key to the discovery was the rational exploration of the initial HTS hit 13 guided by an overlay model built with reported mGlu2 receptor PAM chemotypes. The initial weak in vitro activity of the hit 13 was quickly improved, although compounds still had suboptimal druglike properties. Subsequent modulation of the physicochemical properties resulted ...
Tópico(s): Molecular Sensors and Ion Detection
2012 - American Chemical Society | Journal of Medicinal Chemistry
D. Jiménez‐Gallo, C. Albarrán Planelles, M. Linares‐Barrios, María José Fernández Anguita, Juan Márquez Enríquez, María Eugenia Rodríguez Mateos,
Pruritus is a symptom that significantly affects the patient's quality of life in cutaneous T cell lymphoma (CTCL). The most effective treatments are those that address the condition itself; however, it is often not possible to control this symptom. Lymphoma-related pruritus normally becomes more severe as CTCL progresses, constituting an important factor for quality of life in these patients. Substance P is a neuromodulator which appears to play a key role in pruritus. Aprepitant is a neurokinin- ...
Tópico(s): Nail Diseases and Treatments
2013 - Wiley | Dermatologic Therapy
Francisco Escamilla‐Sevilla, Adolfo Mínguez‐Castellanos, Ventura Arjona‐Morón, José María Martín‐Linares, J C Sánchez-Alvarez, Angel Ortega‐Morenoa, Teresa García‐Gómez,
Abstract We present a 24‐year‐old man with idiopathic segmental cervical and truncal dystonia of juvenile onset. His condition improved after unilateral stimulation of the internal globus pallidus ipsilateral to the contracting sternocleidomastoid muscle. © 2002 Movement Disorder Society
Tópico(s): Genetic Neurodegenerative Diseases
2002 - Wiley | Movement Disorders
Nicolás Guil, José María González-Linares, Julián Ramos Cózar, Emilio L. Zapata,
In this work, a new method for detecting copies of a query video in a videos database is proposed. It includes a new clustering technique that groups frames with similar visual content, maintaining their temporal order. Applying this technique, a keyframe is extracted for each cluster of the query video. Keyframe choice is carried out by selecting the frame in the cluster with maximum similarity to the rest of frames in the cluster. Then, keyframes are compared to target videos frames in order to ...
Tópico(s): Multimedia Communication and Technology
2007 - Springer Science+Business Media | Lecture notes in computer science
Julián Ramos Cózar, Nicolás Guil, José María González-Linares, Emilio L. Zapata, Ebroul Izquierdo,
In conventional video production, logotypes are used to convey information about content originator or the actual video content. Logotypes contain information that is critical to infer genre, class and other important semantic features of video. This paper presents a framework to support semantic-based video classification and annotation. The backbone of the proposed framework is a technique for logotype extraction and recognition. The method consists of two main processing stages. The first stage ...
Tópico(s): Image Retrieval and Classification Techniques
2007 - Elsevier BV | Signal Processing Image Communication
Juan Gómez-Luna, José María González-Linares, J.I. Benavides, Nicolás Guil,
Tópico(s): Medical Image Segmentation Techniques
2012 - Springer Science+Business Media | Machine Vision and Applications