Produção Nacional
Revisado por pares
Jeanine Maria Sobral Nunes, José Maria Ximenes Guimarães, José Jackson Coelho Sampaio,
Resumo Objetiva-se compreender as razões de implantação do modelo de atenção psicossocial territorial, seus avanços e desafios na produção do cuidado, no atual movimento de Reforma Psiquiátrica ocorrido em Fortaleza, Ceará. A pesquisa é de natureza qualitativa, por via de estudo de caso, contextualizado historicamente, e de aproximação com o método dialético, tecnicamente, por meio de entrevista e grupo focal, com resultados submetidos à Análise do Discurso Coletivo. Os resultados e a discussão ...
Tópico(s): Psychology and Mental Health
2016 - UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO | Physis Revista de Saúde Coletiva
Produção Nacional
Revisado por pares
Elizabeth de Magalhães Massena Ferreira, R. Lamour, José Maria Nunes Carmo, José Luiz Mantovano, Marcelo Souza de Carvalho,
Tópico(s): X-ray Spectroscopy and Fluorescence Analysis
2004 - Elsevier BV | Microchemical Journal
Produção Nacional
Revisado por pares
Darízy Flávia Silva, Mônica Moura de Almeida, Cinthia Guedes Chaves, Ana Letícia Braz, Maria Aparecida Gomes, Leidiane Pinho‐da‐Silva, Jorge L. Pesquero, Viviane A. Andrade, Maria de Fátima Leite, José George Ferreira de Albuquerque, Islania Giselia Albuquerque Araújo, Xirley Pereira Nunes, José Maria Barbosa‐Filho, Jáder Santos Cruz, Nádja de Azevedo Correia, Isac Almeida de Medeiros,
In this study, our aims were to investigate transient receptor potential melastatin-8 channels (TRPM8) involvement in rotundifolone induced relaxation in the mesenteric artery and to increase the understanding of the role of these thermosensitive TRP channels in vascular tissue. Thus, message and protein levels of TRPM8 were measured by semi-quantitative PCR and western blotting in superior mesenteric arteries from 12 week-old Spague-Dawley (SD) rats. Isometric tension recordings evaluated the relaxant ...
Tópico(s): Essential Oils and Antimicrobial Activity
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Maria da Conceição Rodrigues Gonçalves, Margareth de Fátima Formiga Melo Diniz, José Damião C. Borba, Xirley Pereira Nunes, José Maria Barbosa‐Filho,
A dislipidemia é considerada um dos fatores de risco mais importantes para o desenvolvimento da doença arterial coronariana. Como resultado, tratamentos efetivos com fármacos foram desenvolvidos para combatê-la, porém, apresentam alto custo e efeitos colaterais. Considerando este fato, pacientes têm recorrido a tratamentos utilizando alimentos conhecidos científica e popularmente por possuírem efeito hipolipemiante. Várias pesquisas vêm sendo realizadas com esses alimentos como a berinjela no sentido ...
Tópico(s): Food Science and Nutritional Studies
2006 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Produção Nacional
Marliane de Cássia Soares da Silva, Mateus Dias Nunes, José Maria Rodrigues da Luz, Maria Catarina Megumi Kasuya,
Selenium (Se) is an essential element to human. However, this element can be in low content in soil of some regions. Se deficiency may cause Keshan disease, thyroid dysfunction and osteoarthritis. The Se-enriched cereals are an interesting way to prevent these diseases. But, recent studies have shown that Se-enriched mushrooms are a better Se source. This occurs due to the high capacity of the fungi to absorb and transform the inorganic Se to organic forms, which are more bioavailable. Pleurotus ...
Tópico(s): Heavy Metals in Plants
2013 - Scientific Research Publishing | Advances in Microbiology
Daniel Olmeda, Cristiano Premebida, Urbano Nunes, José María Armingol, Arturo de la Escalera,
This paper presents an experimental study on pedestrian classification and detection in far infrared (FIR) images. The study includes an in-depth evaluation of several combinations of features and classifiers, which include features previously used f
Tópico(s): Advanced Measurement and Detection Methods
2013 - IOS Press | Integrated Computer-Aided Engineering
Produção Nacional
Revisado por pares
Regiane Gonçalves Feitosa Leal Nunes, José Maria Rodrigues da Luz, Rodrigo de B. Freitas, Angela Higuchi, Maria Catarina Megumi Kasuya, Maria Cristina Dantas Vanetti,
Abstract: Mushrooms have effective mechanisms to absorb and accumulate trace elements from substrates and, therefore could be used as a strategy to produce mineral‐enriched food and nutritional supplements. This study aimed to enrich shiitake mushrooms with selenium (Se), an important dietary element in human health. Strains of Lentinula edodes (Berk.) were grown on artificial logs composed of eucalyptus sawdust, and were subjected to cold shock in water containing sodium selenite (Na 2 SeO 3 ) at concentrations ...
Tópico(s): Heavy Metals in Plants
2012 - Wiley | Journal of Food Science
Produção Nacional
Mateus Dias Nunes, José Maria Rodrigues da Luz, Sirlaine Albino Paes, João Júlio Oliveira Ribeiro, Marliane de Cássia Soares da Silva, Maria Catarina Megumi Kasuya,
Mushrooms have been used for food and medicinal purposes since ancient times. The ? glucans found in mushrooms are currently considered to be responsible for some of the medicinal properties of mushrooms, thereby motivating studies to improve the content of these compounds in fungi and to understand their mechanisms of action. In this study, we tested the effect of nitrogen supplementation on the productivity and nutritional composition of Pleurotus ostreatus mushrooms. P. ostreatus mushrooms were ...
Tópico(s): Food Quality and Safety Studies
2012 - Canadian Center of Science and Education | Journal of Food Research
Produção Nacional
Revisado por pares
Darízy Flávia Silva, Islania Giselia Albuquerque Araújo, José George Ferreira de Albuquerque, Dayanne Lopes Porto, Katy Lísias Gondim Dias, Karla Veruska Marques Cavalcante, Robson Cavalcante Veras, Xirley Pereira Nunes, José Maria Barbosa‐Filho, Demétrius A. M. Araújo, Jáder Santos Cruz, Nadja A. Correia, Isac Almeida de Medeiros,
Abstract: Rotundifolone is the major constituent of the essential oil of Mentha x villosa Hudson. In preliminary studies, rotundifolone induced significant hypotensive, bradycardic and vasorelaxant effects in rats. Thus, to gain more insight into the pharmacology of rotundifolone, the aim of this study was to characterize the molecular mechanism of action involved in relaxation produced by rotundifolone. The relaxant effect was investigated in rat superior mesenteric arteries by using isometric ...
Tópico(s): Marine Toxins and Detection Methods
2011 - Wiley | Basic & Clinical Pharmacology & Toxicology
Produção Nacional
Revisado por pares
Horacinna M.M. Cavalcante, Thaís Pôrto Ribeiro, Darízy Flávia Silva, Xirley Pereira Nunes, José Maria Barbosa‐Filho, Margareth de Fátima Formiga Melo Diniz, Nadja A. Correia, Valdir A. Braga, Isac Almeida de Medeiros,
Abstract: The mechanisms underlying the cardiovascular responses evoked by milonine (i.v.), an alkaloid, were investigated in rats. In normotensive rats, milonine injections produced hypotension and tachycardia, which were attenuated after N w ‐nitro‐ l ‐arginine methyl esther ( l ‐NAME; 20 mg/kg, i.v.). In phenylephrine (10 μM), pre‐contracted mesenteric artery rings, milonine (10 −10 M to 3 × 10 −4 M) caused a concentration‐dependent relaxation (EC 50 = 1.1 × 10 −6 M, E max = 100 ± 0.0%) and this effect was rightward ...
Tópico(s): Chemical synthesis and alkaloids
2010 - Wiley | Basic & Clinical Pharmacology & Toxicology
Produção Nacional
Revisado por pares
Marcos Antônio Alves de Medeiros, Xirley Pereira Nunes, José Maria Barbosa‐Filho, Virgı́nia S. Lemos, José Felippe Pinho, Danilo Roman‐Campos, Isac Almeida de Medeiros, Demétrius A. M. Araújo, Jáder Santos Cruz,
Tópico(s): Electrochemical Analysis and Applications
2008 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Produção Nacional
Revisado por pares
Damião Pergentino de Sousa, Genival Araujo dos Santos Júnior, Luciana Nalone Andrade, Flávia R. Calasans, Xirley Pereira Nunes, José Maria Barbosa‐Filho, Josemar Sena Batista,
Abstract Rotundifolone, a monoterpene isolated from the essential oil of the leaves of Mentha x villosa, is a constituent of several essential oils and known to have spasmolytic activity. The present study aimed to investigate the correlation between structure and spasmolytic activity of rotundifolone and its analogues in ileum isolated from guinea-pig. Five of the seven tested analogues were found to have a spasmolytic effect more potent than rotundifolone itself, except for pulegone and (+)-limonene. ...
Tópico(s): Phytochemistry and Biological Activities
2008 - De Gruyter | Zeitschrift für Naturforschung C
Produção Nacional
Revisado por pares
Damião Pergentino de Sousa, Edison V. M. Júnior, Fernando S. Oliveira, Reinaldo Nóbrega de Almeida, Xirley Pereira Nunes, José Maria Barbosa‐Filho,
Rotundifolone, a monoterpene isolated from the essential oil of the leaves of Mentha x villosa, is a constituent of several essential oils and known to have antinociceptive activity. Our recent study demonstrated that the analogues of rotundifolone showed also a significant antinociceptive effect. In the present report, to investigate the correlation between the structure and antinociceptive activity, rotundifolone and its analogues were evaluated in the acetic acid-induced writhing test in mice. ...
Tópico(s): Synthesis and biological activity
2007 - De Gruyter | Zeitschrift für Naturforschung C
Heloísa G. dos Santos, Helena C. Fernandes, José Luiz Nunes, Maria Rosário Almeida,
Santos, Heloísa Gonçalves; Fernandes, Helena C.; Nunes, José L.; Almeida, Maria R. Author Information
Tópico(s): Connective tissue disorders research
2008 - Lippincott Williams & Wilkins | Clinical Dysmorphology
Alexandra Nunes, Maria José Borrego, Baltazar Nunes, Carlos Florindo, João Paulo Gomes,
ABSTRACT Chlamydia trachomatis is the trachoma agent and causes most bacterial sexually transmitted infections worldwide. Its major outer membrane protein (MOMP) is a well-known porin and adhesin and is the dominant antigen. So far, investigation of MOMP variability has been focused mainly on molecular epidemiological surveys. In contrast, we aimed to evaluate the impact of the host pressure on this key antigen by analyzing its evolutionary dynamics in 795 isolates from urogenital infections, taking ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2009 - American Society for Microbiology | Journal of Bacteriology
Produção Nacional
Revisado por pares
Alexis Calafange Medeiros, Dalila Regina Mota de Melo, Márcia Michelle de Queiroz Ambrósio, Glauber Henrique de Sousa Nunes, José Maria da Costa,
RESUMOA utilização de métodos de inoculação constitui uma medida estratégica no estudo de resistência das cucurbitáceas. O objetivo deste trabalho foi avaliar dois métodos de inoculação de Rhizoctonia solani e Macrophomina phaseolina em meloeiro, visando o estudo de resistência. O experimento foi conduzido em casa de vegetação na Universidade Federal Rural do Semiárido, em Mossoró-RN, Brasil. Foram avaliados 05 acessos: A-09, A-16, A-18, A-22 e A-33 para R. solani e A-09, A-16, A-24, MR-1 e 'Olimpic' ...
Tópico(s): Plant Virus Research Studies
2015 - Grupo Paulista de Fitopatologia | Summa Phytopathologica
Produção Nacional
Revisado por pares
Maria José Nunes de Paiva, Maria Elisa Pereira Bastos de Siqueira,
The objective was to evaluate total serum bile acids (SBA) as a biological marker of hepatotoxicity in car painters exposed to organic solvents and to compare their performance with classic biochemical parameters of liver function. SBA were analysed in a selected group of workers (n=57) occupationally exposed to a mixture of organic solvents and in a control group (n=51). In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TB), gamma-glutamyltransferase (GGT) ...
Tópico(s): Pesticide Exposure and Toxicity
2005 - Taylor & Francis | Biomarkers
Produção Nacional
Francisco José Nunes Modesto, Maria Ângela Cruz Macêdo dos Santos, Tales Miler Soares, Ellen Paula Menezes Dos Santos,
... QUIABEIRO SUBMETIDO À SALINIDADE EM CONDIÇÕES HIDROPÔNICAS FRANCISCO JOSÉ NUNES MODESTO1; MARIA ÂNGELA CRUZ MACÊDO DOS SANTOS1; TALES MILER SOARES2 ...
Tópico(s): Geography and Environmental Studies
2019 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Irriga
Produção Nacional
Revisado por pares
A. F. F. Oliveira, Patrı́cia Penido Maia, Maria José Nunes de Paiva, Maria Elisa Pereira Bastos de Siqueira,
2,5-Hexanedione (2,5-HD) is the most important metabolite of n-hexane and methyl ethyl ketone in human urine. Urinary 2,5-HD is used as a biomarker for biological monitoring of workers exposed to n-hexane. A simple method using headspace solid-phase microextraction (HS-SPME) and gas chromatography (GC) equipped with a flame-ionization detector (FID) was developed. The parameters that affect the HS-SPME-GC-FID process were optimized (i.e., fiber coating, sample volume, adsorption and heating time, salt ...
Tópico(s): Advanced Chemical Sensor Technologies
2009 - Oxford University Press | Journal of Analytical Toxicology
Produção Nacional
Revisado por pares
Flavio Nunes Pereira, José Maria Campos dos Santos,
Tópico(s): Vehicle Noise and Vibration Control
2020 - Elsevier BV | Mechanical Systems and Signal Processing
Produção Nacional
Revisado por pares
Adriano Goto, Edilson Dantas Nóbrega, Flavio Nunes Pereira, José Maria Campos dos Santos,
Tópico(s): Aerodynamics and Acoustics in Jet Flows
2020 - Elsevier BV | International Journal of Mechanical Sciences
Produção Nacional
Revisado por pares
Emídio Vasconcelos Leitão da Cunha, Yvana Fechine, Diego Nunes Guedes, José Maria Barbosa‐Filho, Marcelo Sobral da Silva,
This chapter presents chemotaxonomic compilation of protoberberine alkaloids, 13C NMR data of the protoberberine alkaloids and discusses biological activity of the protoberberine alkaloids. The protoberberine alkaloids are comprised of a tetracyclic ring system, which is based on the dibenzo[a,g]quinolizidine system. These tetracyclic alkaloids are derived from benzylisoquinolines through phenolic oxidation and coupling with the isoquinoline N-methyl group, which becomes the ''berberine bridge'' carbon. ...
Tópico(s): Botanical Research and Chemistry
2005 - Elsevier BV | The Alkaloids. Chemistry and biology/The alkaloids. Chemistry and biology
Cátia Rebelo de Almeida, Raquel Valente Mendes, Anna Pezzarossa, Joaquim Gago, Carlos Carvalho, António Alves, Vitor Moreira Nunes, María José Brito, Maria João Cardoso, Joana Ribeiro, Fátima Cardoso, Miguel Godinho Ferreira, Rita Fior,
Abstract Despite promising preclinical results, average response rates to anti-VEGF therapies, such as bevacizumab, are reduced for most cancers, while incurring in remarkable costs and side effects. Currently, there are no biomarkers available to select patients that can benefit from this therapy. Depending on the individual tumor, anti-VEGF therapies can either block or promote metastasis. In this context, an assay able to predict individual responses prior to treatment, including the impact on ...
Tópico(s): Receptor Mechanisms and Signaling
2020 - Nature Portfolio | Communications Biology
V. M. B. Nunes, Maria José Lourenço, F. J. V. Santos, C. A. Nieto de Castro,
Molten salts are a very relevant member of industrial fluids for high temperature applications, such as catalytic medium for coal gasification, molten salt oxidation of wastes, heat transfer fluids or latent, sensible heat storage and solar (CSP) or nuclear power station operations. Available data on thermophysical properties, applications and a discussion of the state of the art for molten alkali carbonates and its mixtures like pure Li2CO3, Na2CO3 and K2CO3, mixtures of Li2CO3-Na2CO3, Li2CO3-K2CO3 ( ...
Tópico(s): Thermal Expansion and Ionic Conductivity
2019 - Elsevier BV | Applied Energy
Produção Nacional
Revisado por pares
Airton Zancanaro, Carolina Schmitt Nunes, María José Carvalho de Souza Domingues,
For the hosting, management and delivery of Massive Open Online Courses (MOOC) it is necessary a technological infrastructure that supports it. Various educational institutions do not have or do not wish to invest in such a structure, possibly because MOOCs are not yet part of official programs of universities, but initiatives by a particular teacher or a research group. Focusing on this problem, this study seeks to identify platforms that make it possible to create, host and provide courses free ...
Tópico(s): Online Learning and Analytics
2017 - Anadolu University | Turkish Online Journal of Distance Education
Dayane Aparecida Scaramal, Maria do Carmo Fernandez Lourenço Haddas, Mara Lúcia Garanhani, Elisabete de Fátima Pólo de Almeida Nunes, Maria José Quina Galdino, Paloma de Souza Cavalcante Pissinati,
Tópico(s): Disaster Response and Management
2017 - UNIVERSIDADE FEDERAL DE MINAS GERAIS | Reme Revista Mineira de Enfermagem
Jorge Lima, Catarina Martins, Maria Leandro, Glória Nunes, Maria José Rego de Sousa, Jaime Branco, Luís Miguel Borrego,
B cells play a role in pregnancy due to their humoral and regulatory activities. To our knowledge, different maturational stages (from transitional to memory) of circulating B cell subsets have not yet been characterized (cell quantification and phenotype identification) in healthy pregnant women. Thus, the objective of our study was to characterize these subsets (as well as regulatory B cells) from late pregnancy to post-partum and to compare them with the circulating B cells of non-pregnant women. ...
Tópico(s): Diabetes and associated disorders
2016 - BioMed Central | BMC Pregnancy and Childbirth
Jorge Lima, Catarina Martins, Glória Nunes, Maria José Rego de Sousa, Jaime Branco, Luís Miguel Borrego,
Tópico(s): Immune Cell Function and Interaction
2016 - Springer Nature | Reproductive Sciences
Rita Ferreira, Vítor Borges, Alexandra Nunes, Maria José Borrego, João Paulo Gomes,
Chlamydia trachomatis maintain a conserved plasmid, which is a primary regulator of chromosomal genes, but there is no experimental evidences associating it with the strains' differential tissue tropism (ocular and genital mucosae, and lymph nodes). We investigated if the number of plasmids per strain correlate with expression profiles of plasmid ORFs and small anti-sense RNAs (sRNAs), and also if these molecular features underlie tropism dissimilarities. We performed absolute and relative qPCR to ...
Tópico(s): Urinary and Genital Oncology Studies
2013 - Elsevier BV | Microbiological Research
Alexandra Nunes, Maria José Borrego, João Paulo Gomes,
The obligate intracellular pathogen Chlamydia trachomatis is the causative agent of the blinding trachoma and the world's leading cause of bacterial sexually transmitted infections. Despite aggressive antibacterial control measures, C. trachomatis infections have been increasing, constituting a serious public health concern due to its morbidity and socioeconomic burden. Still, very little is known about the molecular basis underlying the phenotypic disparities observed among C. trachomatis serovars ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2013 - Elsevier BV | Infection Genetics and Evolution