Miguel de Mulder Rougvie, Gonzalo Yebra, Adriana Navas, María Isabel de José, María Dolores Gurbindo, María Isabel González-Tomé, María José Mellado, Jesús Saavedra‐Lozano, María Ángeles Muñoz‐Fernández, Santiago Jiménez de Ory, José Tomás Ramos, África Holguín,
Background Antiretroviral treatment (ART) has contributed to increased life expectancy of HIV-1 infected children. In developed countries, an increasing number of children reaching adulthood are transferred to adult units. The objectives were to describe the demographic and clinical features, ART history, antiviral drug resistance and drug susceptibility in HIV-1 perinatally infected adolescents transferred to adult care units in Spain from the Madrid Cohort of HIV-1 infected children. Methods Clinical, ...
Tópico(s): HIV Research and Treatment
2012 - Public Library of Science | PLoS ONE
Martim Sousa, Ana Maria Tomé, José Moreira,
In this study, we address a demanding time series forecasting problem that deals simultaneously with the following: (1) intermittent time series, (2) multi-step ahead forecasting, (3) time series with multiple seasonal periods, and (4) performance measures for model selection across multiple time series. Current literature deals with these types of problems separately, and no study has dealt with all these characteristics simultaneously. To fill this knowledge gap, we begin by reviewing all the necessary ...
Tópico(s): Time Series Analysis and Forecasting
2022 - KeAi | Data Science and Management
Norberto Mangiavacchi, A. Castelo, Murilo Francisco Tomé, José Alberto Cuminato, Maria Oliveira, S. McKee,
This work presents a method for simulating axisymmetric and planar free-surface flows dominated by surface tension forces. The surface tension effects are incorporated into the free surface boundary conditions through the computation of the capillary pressure. The required curvature is evaluated by fitting a least squares curve to the free surface using the tracking markers in the cell and in its close neighbors. To avoid short wavelength perturbations on the free surface, a mass-conserving local ...
Tópico(s): Surface Modification and Superhydrophobicity
2005 - Society for Industrial and Applied Mathematics | SIAM Journal on Scientific Computing
María Tomé Fernández, José Manuel Ortiz-Marcos, Eva María Olmedo Moreno,
The objective of this research is to adapt and validate a useful instrument to diagnose cyberbullying, provoked by intolerance towards cultural and religious diversity, identifying the profile of the aggressor and the victim. The study was carried out using the Delphi technique, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA). The selected sample was composed of 1478 adolescents, all students from Compulsory Secondary Education of Spain. The instrument items were extracted ...
Tópico(s): Child Development and Digital Technology
2019 - Multidisciplinary Digital Publishing Institute | Religions
Talía Sainz, María Álvarez-Fuente, Rodrigo Fernández‐Jiménez, María Isabel González-Tomé, María Isabel de José, José Tomás Ramos, María Luisa Navarro, Jorge Martínez, Milagros García-Hortelano, Constancio Medrano, María Ángeles Muñoz‐Fernández, María José Mellado,
Previous studies have demonstrated increased risk of adverse cardiac outcomes in adults with HIV infection. However, few studies have addressed this problem in vertically HIV-infected children and adolescents, and the long-term cardiac health of this unique population in the antiretroviral therapy era is still unknown.Ventricular function was evaluated cross-sectionally in a group of HIV-infected children and adolescents and healthy controls, using conventional echocardiography along with tissue ...
Tópico(s): Viral Infections and Immunology Research
2015 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Luis Prieto, Carolina Fernández McPhee, Patricia Rojas, Diana Mazariegos, Eloy Muñoz, María José Mellado, África Holguín, María Luisa Navarro, María Isabel González-Tomé, José Tomás Ramos,
Background An increasing number of perinatally HIV-infected women (PHIV) are reaching adulthood and becoming pregnant. Most PHIV women have been exposed to a high number of antiretroviral regimens, and they may have difficulties to achieve viral suppression. Psychosocial problems are not uncommon and could be an important barrier for treatment adherence. The effects of chronic HIV infection and long-term exposure to antiretroviral treatment of PHIV women cause concerns on the developing fetus. The ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2017 - Public Library of Science | PLoS ONE
María José Martínez-Tomé, Rocío Esquembre, Ricardo Mallavia, C. Reyes Mateo,
Nitrite and selenium are two bioactive compounds found in the environment which show beneficial effects for health at low levels but have toxic effects at higher doses. Consequently, quantification of both analytes in water samples results of great interest in areas such as biomedicine, food technology and environmental analysis. In a recent paper, we immobilized the inclusion complex formed between 2,3-diaminonaphthalene (DAN) and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in a sol-gel matrix, ...
Tópico(s): Sulfur Compounds in Biology
2009 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis
MI González-Tomé, José Tomás Ramos Amador, María José Mellado, María Luisa Navarro Gómez, Pablo Rojo Conejo, P. Martín Fontelos,
Protease inhibitors (PIs) have been associated with metabolic complications. There is a trend to switch to simpler therapy to improve these disturbances. We report a case-series describing the effects in metabolic abnormalities in seven HIV-infected children, previously treated with protease inhibitor (PI) after switching to nevirapine. Seven children with stable PI-containing regimen and a long lasting HIV-1 RNA < 50 copies/ml were switched to nevirapine. All patients were naïve to non nucleoside reverse ...
Tópico(s): HIV Research and Treatment
2008 - BioMed Central | BMC Infectious Diseases
Zehra Kahveci, María José Martínez-Tomé, Ricardo Mallavia, C. Reyes Mateo,
The present work explores the potential use of the conjugated cationic polyfluorene {[9,9-bis(6'-N,N,N-trimethylammonium)hexyl]fluorene-phenylene} bromide (HTMA-PFP) as a fluorescent membrane marker. To this end, the interaction of the polyelectrolyte with anionic model membranes has been investigated using different biophysical approaches. High affinity interaction was confirmed through alterations in the fluorescence spectrum of HTMA-PFP and by Förster resonance energy transfer (FRET) analysis. Quenching ...
Tópico(s): Lipid Membrane Structure and Behavior
2013 - American Chemical Society | Biomacromolecules
Zehra Kahveci, María José Martínez-Tomé, Ricardo Mallavia, C. Reyes Mateo,
This work describes the development of a novel fluorescent biosensor based on the inhibition of alkaline phosphatase (ALP). The biosensor is composed of the enzyme ALP and the conjugated cationic polyfluorene HTMA-PFP. The working principle of the biosensor is based on the fluorescence quenching of this polyelectrolyte by p-nitrophenol (PNP), a product of the hydrolysis reaction of p-nitrophenyl phosphate (PNPP) catalyzed by ALP. Because HTMA-PFP forms unstable aggregates in buffer, with low fluorescence ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2016 - American Chemical Society | ACS Applied Materials & Interfaces
Ana F. R. Cerqueira, Nuno M. M. Moura, Vanda Vaz Serra, M. Amparo F. Faustino, Augusto C. Tomé, José A. S. Cavaleiro, Maria G. P. M. S. Neves,
Porphyrins bearing formyl or vinyl groups have been explored as starting materials to prepare new compounds with adequate features for different applications. In this review it is discussed mainly synthetic strategies based on the reaction of meso-tetraarylporphyrins bearing those groups at β-pyrrolic positions. The use of some of the obtained porphyrin derivatives for further transformations, namely via pericyclic reactions, is also highlighted.
Tópico(s): Luminescence and Fluorescent Materials
2017 - Multidisciplinary Digital Publishing Institute | Molecules
Marta Rubio-Camacho, José Antonio Encinar, María José Martínez-Tomé, Rocío Esquembre, C. Reyes Mateo,
The interaction of temozolomide (TMZ) (the main chemotherapeutic agent for brain tumors) with blood components has not been studied at the molecular level to date, even though such information is essential in the design of dosage forms for optimal therapy. This work explores the binding of TMZ to human serum albumin (HSA) and alpha-1-acid glycoprotein (AGP), as well as to blood cell-mimicking membrane systems. Absorption and fluorescence experiments with model membranes indicate that TMZ does not penetrate ...
Tópico(s): Hemoglobin structure and function
2020 - Multidisciplinary Digital Publishing Institute | Biomolecules
María Cruz Matallana González, María José Martínez-Tomé, M. E. Torija Isasa,
The nitrate and nitrite content of leaf vegetables (Swiss chard, sea beet, spinach and cabbage), "inflorescence" vegetables (cauliflower) and fruit vegetables (eggplant and vegetable marrow) grown with organic fertilizers have been determined by a modified cadmium–Griess method. Samples were purchased from organic food stores as well as collected directly from an organic farm in Madrid (Spain). Nitrate levels were much higher in the leaf vegetables (especially Swiss chard species; average over the different ...
Tópico(s): Composting and Vermicomposting Techniques
2010 - Taylor & Francis | Food Additives and Contaminants Part B
María José Martínez-Tomé, Rocío Esquembre, Ricardo Mallavia, C. Reyes Mateo,
The interaction between the conjugated polyelectrolyte poly{[9,9-bis(6'-N,N,N-trimethylammonium)hexyl]fluorene-phenylene} bromide (HTMA-PFP) and human serum albumin (HSA) has been investigated from changes observed in both the spectroscopic properties of HTMA-PFP and the intrinsic fluorescence of HSA. Absorption and fluorescence spectra of HTMA-PFP suggest that HTMA-PFP and HSA form polymer-protein complexes due to electrostatic interactions between the cationic side chains of HTMA-PFP and the negatively ...
Tópico(s): Photochemistry and Electron Transfer Studies
2010 - American Chemical Society | Biomacromolecules
Zehra Kahveci, Rebeca Vázquez-Guilló, María José Martínez-Tomé, Ricardo Mallavia, C. Reyes Mateo,
The design and development of fluorescent conjugated polyelectrolytes (CPEs) emitting in the red region of the visible spectrum is at present of great interest for bioimaging studies. However, despite the wide variety of CPEs available, stable bright red-emitters remain scarce due to their low solubility and instability in aqueous media, consequently limiting their applications. In this work, we have synthesized and characterized a new red-emitting cationic conjugated polyelectrolyte copoly-{[9,9- ...
Tópico(s): Luminescence and Fluorescent Materials
2015 - American Chemical Society | ACS Applied Materials & Interfaces
Miguel de Mulder Rougvie, Gonzalo Yebra, Leticia Martín, Luis Prieto, María José Mellado, Pablo Rojo, María Ángeles Muñoz‐Fernández, Santiago Jiménez de Ory, J. T. Ramos, África Holguín, M. José, María Isabel González-Tomé, M.D. Gurbindo, María Luisa Navarro, Jesús Saavedra‐Lozano, Rafaël Delgado, Pablo Martín-Fontelos, Sara Guillén, José Simón Martínez-Castañeda, Miguel Ángel Roa, José Beceiro, Adriana Navas, I. Gonzalez-Granados, Luis Prieto, María José Mellado, Pablo Rojo, Daniel Blázquez‐Gamero, María Ángeles Muñoz‐Fernández, J. T. Ramos,
Drug resistance mutations affect antiretroviral therapy (ART) effectiveness in HIV-1-infected children, compromising long-term therapy. HIV-1 variants and drug resistance mutations were identified in HIV-infected children from Madrid, Spain. Patients from the Madrid cohort of HIV-infected children (1993–2009) with available pol sequences or infected samples stored at the Spanish HIV-1 BioBank were selected. Specimens were used to perform new pol sequences when not available. HIV-1 variants were characterized ...
Tópico(s): HIV/AIDS Research and Interventions
2011 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Rebeca Vázquez-Guilló, Alberto Falcó, María José Martínez-Tomé, C. Reyes Mateo, M. Antonia Herrero, Ester Vázquez, Ricardo Mallavia,
Polymerization via Suzuki coupling under microwave (µW) irradiation has been studied for the synthesis of poly{1,4-(2/3-aminobenzene)-alt-2,7-(9,9-dihexylfluorene)} (PAF), chosen as molecular model. Briefly, µW-assisted procedures accelerated by two orders of magnitude the time required when using classical polymerization processes, and the production yield was increased (>95%). In contrast, although the sizes of the polymers that were obtained by non-conventional heating reactions were reproducible ...
Tópico(s): Organic Light-Emitting Diodes Research
2018 - Multidisciplinary Digital Publishing Institute | Polymers
Tim Harrison, Pascal Chanez, Francesco Menzella, Giorgio Walter Canonica, Renaud Louis, Borja G. Cosío, Njira Lugogo, Arjun Mohan, Annie Burden, Lawrence McDermott, Esther Garcia Gil, James Zangrilli, Wolfgang Pohl, Robert Voves, Maud Deschampheleire, Renaud Louis, Jean‐Benoît Martinot, Rudi Peché, Kenneth R. Chapman, Amarjit Cheema, Delbert R. Dorscheid, J. Mark FitzGerald, Rémi Gagnon, William Patrick Killorn, Ronald Olivenstein, George Philteos, Clare D. Ramsey, Julia Rolf, Brandie Walker, Ole Hilberg, Tina Skjold, Ingrid Louise Titlestad, Auli Hakulinen, Maritta Kilpeläinen, M. Ben Hayoun, Philippe Bonniaud, Arnaud Bourdin, Pascal Chanez, Frédéric de Blay, Gaëtan Deslée, Gilles Devouassoux, A. Didier, Y. Douadi, Stéphanie Fry, Gilles Garcia, Pierre‐Olivier Girodet, Christophe Leroyer, A. Magnan, Guillaume Mahay, C. Nocent, Christophe Pison, Pauline-Marie Roux, Camille Taillé, Juliana-Angelica Tiotiu, Ekkehard Beck, Margret Jandl, Christian Kaehler, F Käßner, Frank Koesters, Juliane Kronsbein, Thomas Schaum, Christian Schulz, Dirk Skowasch, Christian Taube, Tobias Welte, A de Roux, Bianca Beghè, Francesco Blasi, Giorgio Walter Canonica, Giovanna Elisiana Carpagnano, Cristiano Caruso, Angelo Guido Corsico, Elio Constantino, Nunzio Crimi, Piero Maestrelli, Francesco Menzella, Manlio Milanese, Alberto Papi, Girolamo Pelaia, Laura Pini, Pierachille Santus, Eleonora Savi, Nicola Scichilone, Gianenrico Senna, Giuseppe Spadaro, Adriano Vaghi, Steven Gans, Jürgen Hölters, Bas Langeveld, Willem R. Pieters, Gerald Staaks, Ilonka van Veen, Jan Willem van den Berg, Gunnar Einvik, Sverre Lehmann, Ismael Ali García, Carlos Almonacid, Irina Bobolea, Paloma Campo Mozo, Gustavo de Luiz, Christian Domingo, José María Echave-Sustaeta María-Tomé, Juan Luis García‐Rivero, Borja G. Cosío, A. Gómez-Bastero Fernández, Ruperto González‐Pérez, Aythamy Henríquez Santa, Carlos Martínez‐Rivera, Xavier Muñoz, Jacinto Ramos, José Gregorio Soto Campos, Carmen Vidal Pan, Nikolai Stenfors, Alf Tunsäter, Ines Vinge, Rekha Chaudhuri, Timothy Harrison, Adel Mansur, Shuaib Nasser, Monica Nordstrom, Paul Pfeffer, Dinesh Saralaya, Philip Short, Arun Adlakha, Oral Alpan, Francis Averill, Anil Badhwar, Jose Bardelas, Barbara D. Baxter, George Bensch, William Berger, Jonathan A. Bernstein, Tracy Bridges, Ryan Brimeyer, William J. Calhoun, Edward J. Campbell, W. Brett Cherry, Geoffrey Chupp, Lee Clore, John R. Cohn, Jeremy Cole, John J. Condemi, James Cury, Benjamin Davis, Samuel DeLeon, Luis DeLaCruz, Joseph D. Diaz, David Erb, Emeka Eziri, Faisal Fakih, Douglas Fiedler, David A. Fost, Stephen B. Fritz, E. González González, Brad Goodman, Peter A. Gottlieb, Gregory Gottschlich, Richard Gower, Rizan Hajal, James B. Harris, Hengameh Heidarian-Raissy, Albrecht Heyder, David A. Hill, Fernando Holguín, Iftikhar Hussain, Jonathan Illowite, Joshua Jacobs, Mikell Jarratt, Harold B. Kaiser, Neil L. Kao, Ravindra Kashyap, David Kaufman, Edward Kent, Kenneth Kim, Ryan Klein, Monica Kraft, Ritsu Kono, Shahrukh Kureishy, Jeffrey Leflein, Mila A. Leong, Huamin Li, Robert Y. Lin, Njira Lugogo, Michael Marcus, Diego Jose Maselli Caceres, Vinay Mehta, Curtis J. Mello, Mark Millard, Aaron P. Milstone, Arjun Mohan, Wendy C. Moore, Mark Moss, N. Mumneh, Thomas D. O’Brien, David Ostransky, Michael Palumbo, Purvi Parikh, Sudhir Parikh, Amit Patel, Guido O. Pérez, W PLESKOW, Bruce M. Prenner, Dileep Puppala, John Ramey, Joan Reibman, Ramón López de los Reyes, Emory Robinette, Ileana Rodicio, Stephen Ryan, Sudhir Sekhsaria, Barry Sigal, Vinay Sikand, Weily Soong, Selwyn Spangenthal, Roy St. John, Gary C. Steven, Vijay Subramaniam, Kaharu Sumino, Eric Sztejman, Ricardo Tan, Tonny Tanus, Charles S. Thompson, Carl E. Thornblade, Manuel Villareal, Sally E. Wenzel, Heidi Zafra, Tomasz M. Ziedalski,
Background ANDHI was done to assess the efficacy of benralizumab, including onset of effect and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and nasal polyposis symptoms. Methods This phase 3b, randomised, double-blind, parallel-group, placebo-controlled ANDHI study was completed in adults (aged 18–75 years) with severe eosinophilic asthma with at least 2 exacerbations in the previous year, despite high-dose inhaled corticosteroid plus additional controllers, ...
Tópico(s): Pediatric health and respiratory diseases
2020 - Elsevier BV | The Lancet Respiratory Medicine
María José Martínez-Tomé, Rocío Esquembre, Ricardo Mallavia, C. Reyes Mateo,
Tópico(s): Electrochemical sensors and biosensors
2008 - Springer Science+Business Media | Journal of Fluorescence
Zehra Kahveci, María José Martínez-Tomé, Rocío Esquembre, Ricardo Mallavia, C. Reyes Mateo,
This paper explores the interaction mechanism between the conjugated polyelectrolyte {[9,9-bis(6'-N,N,N-trimethylammonium)hexyl]fluorene-phenylene}bromide (HTMA-PFP) and model lipid membranes. The study was carried out using different biophysical techniques, mainly fluorescence spectroscopy and microscopy. Results show that despite the preferential interaction of HTMA-PFP with anionic lipids, HTMA-PFP shows affinity for zwitterionic lipids; although the interaction mechanism is different as well as ...
Tópico(s): Molecular Sensors and Ion Detection
2014 - Multidisciplinary Digital Publishing Institute | Materials
José María Casellas, Gabriella Tomé, Carlos Bantar, Pamela Bertolini, N. Blázquez, Noemí Borda, Elsa Couto, Norma Cudmani, Josefina Guerrera, María Josefina Juárez, Teresa Margarita Torres López, Ana Littvik, Emilce Méndez, Rodolfo Notario, Graciela Ponce, Mirta Quinteros, Francisco Salamone, Mónica Sparo, Emma Sutich, Susana Vaylet, Lidia Wolff,
Tópico(s): Antimicrobial Resistance in Staphylococcus
2003 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Pablo Guisado‐Vasco, Sofia Valderas-Ortega, María Maravillas Carralón-González, Ana Roda-Santacruz, Lucía González‐Cortijo, Gabriel Sotres-Fernández, Eva María Martí-Ballesteros, José Manuel Luque-Pinilla, Elena Almagro-Casado, Félix J. La Coma-Lanuza, Ruth Barrena-Puertas, Esteban Javier Malo-Benages, María José Monforte-Gómez, Rocío Diez-Munar, Esther Merino-Lanza, Lorena Comeche-Casanova, Margarita Remirez-de-Esparza-Otero, María Correyero Plaza, Manuel Recio-Rodríguez, Margarita Rodríguez-López, María Dolores Sánchez-Manzano, Cristina Andreu‐Vázquez, Israel Thuissard, José María Echave-Sustaeta María-Tomé, Daniel Carnevali-Ruiz,
BackgroundThe COVID-19 outbreak challenges the Spanish health system since March 2020. Some available therapies (antimalarials, antivirals, biological agents) were grounded on clinical case observations or basic science data. The aim of this study is to describe the characteristics and impact of different therapies on clinical outcomes in a cohort of severe COVID-19 patients.MethodsIn this retrospective, single-center, observational study, we collected sequential data on adult patients admitted to ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2020 - Elsevier BV | EClinicalMedicine
José Antonio Suárez Navarro, Alfredo Fernández-Landa, José Luis Pensado Tomé, María Luz Guillén-Climent, Juan Carlos Ojeda,
Airborne laser scanning (ALS) is commonly used in forest mapping. Full coverage of ALS is already available in some countries to provide high-detailed terrain elevation models. These kinds of data sets have been shown to offer great potential in forest mapping. However, it presents some drawbacks such as the resampling periods may be longer than recommended for forestry purposes or unexpected data updates. The recent development of digital photogrammetric algorithms makes dense image matching (DIM) ...
Tópico(s): Forest Ecology and Biodiversity Studies
2018 - Taylor & Francis | International Journal of Remote Sensing
Yolanda Alacid, María José Martínez-Tomé, C. Reyes Mateo,
A highly stable and reusable fluorescent multisample nanobiosensor for the detection of α-glucosidase inhibitors has been developed by coupling fluorescent liposomal nanoparticles based on conjugated polymers (L-CPNs) to the enzyme α-glucosidase, one of the main target enzymes in the treatment of type 2 diabetes. The mechanism of sensing is based on the fluorescence "turn-on" of L-CPNs by p-nitrophenol (PNP), the end product of the enzymatic hydrolysis of p-nitrophenyl-α-d-glucopyranoside. L-CPNs, ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2021 - American Chemical Society | ACS Applied Materials & Interfaces
S. Tomé-Rodríguez, Carlos A. Ledesma‐Escobar, José María Penco-Valenzuela, Feliciano Priego‐Capote,
Volatile compounds are responsible for the valued aroma of extra virgin olive oil (EVOO). Among them, it is worth emphasizing the relevance of C6 and C5 volatiles formed in the lipoxygenase pathway. These compounds are direct indicators of positive attributes such as fruity, sweet, green or ripeness. Here, we have analyzed the volatile profile of 193 EVOOs obtained in two consecutive seasons to evaluate the cultivar influence and the interannual variability. We were particularly targeted at C6 and ...
Tópico(s): Horticultural and Viticultural Research
2021 - Elsevier BV | LWT
Alice Maria Almeida, José Tomé, Margarida Tomé,
Tópico(s): Plant Physiology and Cultivation Studies
2010 - Elsevier BV | Forest Ecology and Management
Gonzalo Jiménez‐Osés, José I. Garcı́a, Ana M. G. Silva, Ângela R. Santos, Augusto C. Tomé, Maria G. P. M. S. Neves, José A. S. Cavaleiro,
A DFT study on site selectivity in successive 1,3-dipolar cycloadditions of meso-tetraarylporphyrins with azomethine ylide and N-methylnitrone has been carried out. The calculation of the thermodynamic stability of both ylide and nitrone-derived adducts reveals that bacteriochlorins are more stable and have stronger aromatic character than isobacteriochlorins. Calculations of whole reaction pathways show that cycloadditions of azomethine ylide on porphyrin and its derived chlorin are irreversible ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2008 - Elsevier BV | Tetrahedron
J.V. Pérez-Moreiras, Juan J. Gómez‐Reino, José Ramón Maneiro, Eva Pérez‐Pampín, Angel Romo Lopez, Fernando M. Rodríguez Alvarez, Jesús M. Castillo Laguarta, Aurora del Estad Cabello, M. Gessa-Sorroche, Enrique España Gregori, Marco Sales‐Sanz, Juan J. Gómez‐Reino, José Ramón Maneiro, Maria A. Tome Martinez de Rituerto, Eva Pérez‐Pampín, J.V. Pérez-Moreiras, Alejandro Alvarez, Angel Romo Lopez, Juan Troyano, Cristina Niño, Eva Aladro Vico, Maria C. Montañez Zorrilla, Marco Sales Sanz, Ana M. Martín Ucero, Marcelino Revenga, Enrique España Gregori, Antonia M. Pérez Lazaro, José Todolí, A. Alejos, Fernando M. Rodríguez Alvarez, Cèsar Díaz‐Torné, José M. Cubero Marcos, Jesús M. Castillo Laguarta, Angel Dominguez Polo, L LAVILLA, Cilia Peralta Ginés, Aurora del Estad Cabello, Antonio J. Gómez Escobar, Concepción Díaz, Federico Navarro Sarabia, Tomás Martín Hernández, M. Gessa-Sorroche, Elena Navarro, Estéban Rubio, Rafael Villanueva Blandón, María P. Maiquez,
Objective To demonstrate the efficacy of the anti-interleukin-6 receptor monoclonal antibody tocilizumab in patients with moderate-to-severe corticosteroid-resistant Graves orbitopathy (GO). Design Double-masked randomized clinical trial. Methods Setting and Participants: Thirty-two adults with moderate-to-severe corticosteroid-resistant GO from 10 medical centers in Spain were randomized (1:1). Intervention: Randomization to either 8 mg/kg body weight tocilizumab or placebo administered intravenously ...
Tópico(s): Myofascial pain diagnosis and treatment
2018 - Elsevier BV | American Journal of Ophthalmology
Rebeca Vázquez-Guilló, María José Martínez-Tomé, Zehra Kahveci, Iván Torres‐Moya, Alberto Falcó, Ricardo Mallavia, C. Reyes Mateo,
In the present work, we have synthesized a novel green-emitter conjugated polyelectrolyte Copoly-{[9,9-bis(6'-N,N,N-trimethylammonium)hexyl]-2,7-(fluorene)-alt-4,7-(2-(phenyl) benzo[d] [1,2,3] triazole)} bromide (HTMA-PFBT) by microwave-assisted Suzuki coupling reaction. Its fluorescent properties have been studied in aqueous media and in presence of model membranes of different composition, in order to explore its ability to be used as a green fluorescent membrane probe. The polyelectrolyte was bound ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2018 - Multidisciplinary Digital Publishing Institute | Polymers
Marta Rubio-Camacho, Yolanda Alacid, Ricardo Mallavia, María José Martínez-Tomé, C. Reyes Mateo,
Multifunctional nanoparticles have been attracting growing attention in recent years because of their capability to integrate materials with different features in one entity, which leads them to be considered as the next generation of nanomedicine. In this work, we have taken advantage of the interesting properties of conjugated polyelectrolytes to develop multicolor fluorescent nanoparticles with integrating imaging and therapeutic functionalities. With this end, thermosensitive liposomes were ...
Tópico(s): Dendrimers and Hyperbranched Polymers
2019 - Multidisciplinary Digital Publishing Institute | Nanomaterials