Produção Nacional
Revisado por pares
Bruno José Martins da Silva, Sandro Wilson Gomes Pereira, Ana Paula Rodrigues, José Luíz Martins do Nascimento, Edilene O. Silva,
In the present study, we evaluated the effects of the aqueous extract of Physalis angulata root (AEPa) on Leishmania infantum proliferation, morphology, and the driving mechanism in leishmanicidal activity and modulatory action on macrophages.L. infantum promastigotes were treated with 50 and 100 µg/mL AEPa for 72 h and then antipromastigote assay was performed by counts in a Newbauer chamber, morphological changes were analyzed by transmission electron microscopy and the mechanism of the leishmanicidal ...
Tópico(s): Research on Leishmaniasis Studies
2018 - Elsevier BV | Journal of Integrative Medicine
Produção Nacional
Revisado por pares
Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Fábio Fernandes Galvão Rodrigues, Adriana Rolim Campos,
Plectranthus is one of the most representative genera of Lamiaceae family. In this study, the essential oils from Plectranthus amboinicus , Plectranthus ornatus , and Plectranthus barbatus were investigated for their chemical composition and antimicrobial and modulatory activities. The major components found were carvacrol (54.4%— P. amboinicus ) and eugenol (22.9%— P. ornatus e 25.1%— P. barbatus ). In vitro antimicrobial activity was conducted against Escherichia coli , Proteus vulgaris , Bacillus cereus , Pseudomonas ...
Tópico(s): Insect Pest Control Strategies
2013 - Hindawi Publishing Corporation | Evidence-based Complementary and Alternative Medicine
Produção Nacional
Revisado por pares
F. C. Eduardo, Carlos F. R. C. Guimarães, Lucas Lopardi Franco, Ricardo José Alves, Kelly Cristina Kato, Helen Rodrigues Martins, José Dias de Souza Filho, Marcelo P. Bemquerer, Victor H. O. Munhoz, Jarbas M. Resende, Rodrigo M. Verly,
Tópico(s): Studies on Chitinases and Chitosanases
2017 - Springer Science+Business Media | Amino Acids
Produção Nacional
Revisado por pares
Denise Aline Casimiro Bezerra, Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Andréia Vieira Pereira, Erlânio Oliveira de Sousa, Onaldo Guedes Rodrigues,
The need to find new efficient drugs to combat microbes has increased the search for new natural compounds with biological activities. In this work, phytochemical studies and microbiological analysis were carried out with the ethanol extracts of Mimosa tenuiflora (Wild) Poiret and Piptadenia stipulacea (Benth) Ducke on pathogenic bacteria strains. The bark powders of both species were submitted to bromatologic evaluation and the levels of dry matter, mineral matter, crude protein, neutral detergent ...
Tópico(s): African Botany and Ecology Studies
2011 - Editora da Universidade Estadual de Maringá (Eduem) | Acta Scientiarum Biological Sciences
Produção Nacional
Revisado por pares
Cícera Datiane de Morais Oliveira‐Tintino, Renata Torres Pessoa, Maria Neyze Martins Fernandes, Isabel Sousa Alcântara, Bruno Anderson Fernandes da Silva, Maria Rayane Correia de Oliveira, Anita Oliveira Brito Pereira Bezerra Martins, Maria do Socorro da Silva, Saulo Relison Tintino, Fábio Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Sidney Gonçalo de Lima, Marta Regina Kerntopf, Teresinha Gonçalves da Silva, Irwin Rose Alencar de Menezes,
Inflammation makes up a set of vascularized tissue reactions acting in the defense of the body against harmful stimuli. Natural products are a lower cost alternative with better benefit, often used in popular medicine in the treatment of inflammatory processes. Several species from the genus Croton have scientifically proven anti-inflammatory action. This study aims to analyze the chemical composition of the Croton campestris A. St.-Hil essential oil (EOCC), derived from fresh leaves, as well as ...
Tópico(s): Bioactive Natural Diterpenoids Research
2018 - Elsevier BV | Phytomedicine
Produção Nacional
Revisado por pares
Iziara Ferreira Florentino, Daiany Priscilla Bueno da Silva, Pablinny Moreira Galdino, Roberta Campos Lino, José Luís Rodrigues Martins, Dayane M. Silva, José Realino de Paula, Leonice Manrique Faustino Tresvenzol, Élson Alves Costa,
The leaves and stems bark of Memora nodosa (Silva Manso) Miers (Bignoniaceae) are used in Brazilian traditional medicine in the treatment of external ulcers and wounds; its roots are used to treat abdominal pain and scabies.Our aim was to evaluate the antinociceptive and anti-inflammatory activities of Memora nodosa roots ethanolic extract (EMN) and allantoin, a secondary metabolite isolated from this plant.The EMN and allantoin antinociceptive activity were evaluated in mice using both chemical and ...
Tópico(s): Herbal Medicine Research Studies
2016 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho,
The leaves of Croton zehntneri Pax et Hoffm (Euphorbiaceae) were subjected to hydrodistillation, and the essential oil extracted was examined with respect to antibacterial and antibiotic modifying activity by gaseous contact. The gaseous component of the oil inhibited the bacterial growth of Staphylococcus aureus and Pseudomonas aeruginosa with a MID of 0.5 and<1mg/l air, respectively. The activity of the antibiotic gentamicin was increased by 42,8% against P. aeruginosa after contact with the gaseous ...
Tópico(s): Bioactive Natural Diterpenoids Research
2009 - Elsevier BV | Phytomedicine
Produção Nacional
Revisado por pares
AdrianaRolim Campos, Gerlaniade Oliveira Leite, Antonia RosangelaSoares Penha, GlaubertoQuirino da Silva, Aracélio Viana Colares, Fabíola FernandesGalvao Rodrigues, José Galberto Martins da Costa, AndreLuiz Herzog Cardoso,
Gastric ulcer is a serious gastrointestinal disorder that requires a well targeted therapeutic strategy. A number of drugs are available for the treatment of gastric ulcer, but clinical evaluation has shown incidence of relapses, side effects, and drug interactions. The search for novel molecules has been extended to herbal drugs that offer better protection and decreased relapse. The essential oils from Croton zehntneri (EOCZ) and Vanillosmopsis arborea (EOVA), the oil from Caryocar coriaceum pulp ( ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2009 - | Journal of Young Pharmacists
Produção Nacional
Revisado por pares
N. K. A. Santos, Henrique Douglas Melo Coutinho, Glauce Socorro de Barros Viana, Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa,
Tópico(s): Medicinal Plants and Neuroprotection
2010 - Springer Science+Business Media | Medicinal Chemistry Research
Produção Nacional
Revisado por pares
Francisco Stefânio Barreto, Erlânio Oliveira de Sousa, Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Adriana Rolim Campos,
The use of medicinal plants with therapeutics properties represents a secular tradition in different cultures, mainly in underdeveloped countries. Lantana camara Linn and Lantana montevidensis Briq (Verbenaceae) found in tropical and subtropical areas around the world are popularly known as "camará" or "chumbinho." In popular medicines, both plants are used as antipyretic and carminative and in the treatment of respiratory system infections. In this study, the antibacterial activity of the ethanolic ...
Tópico(s): Phytochemistry and Bioactivity Studies
2010 - | Journal of Young Pharmacists
Produção Nacional
Revisado por pares
Germana Freire Rocha Caldas, Iggor Macêdo do Amaral Costa, Juciene Bezerra Rodrigues da Silva, Rafaella Farias da Nóbrega, Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Almir Gonçalves Wanderley,
Hyptis martiusii (Lamiaceae), popularly known as "cidreira-do-mato" or "cidreira-brava", grows in abundance in the Northeast region of Brazil, where its leaves are traditionally used in folk medicine in the treatment of intestinal and stomach diseases. The aim of this study was to characterize the chemical constituents and to evaluate the anti-ulcerogenic activity of the essential oil of the leaves of Hyptis martiusii (EOHM) in in vivo models of experimental ulcers in rodents.EOHM was obtained by hydrodistillation ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2011 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Fabíola Raquel Tenório Oliveira, Josione Rêgo Ferreira, Carlos Santos, Lano Ermenson Miranda Macêdo, Ricardo Bezerra de Oliveira, José Antunes Rodrigues, José Luíz Martins do Nascimento, L.R.F. Faro, Domingos Luiz Wanderley Picanço Diniz,
The aim of this research was to verify the incidence of endocrine dysfunction associated with mercury intoxication in the hypothalamus-pituitary reproductive system of normally cycling or castrated female rats and the possible protective action of estrogen replacement therapy. We found no differences in the frequency of estrus cycle stages (diestrus I, diestrus II, proestrus, and estrus) in normally cycling female rats during 54 days of daily oral administration of 0.004, 0.02, and 1 mg/kg MeHgCl. ...
Tópico(s): Mercury impact and mitigation studies
2005 - Elsevier BV | Ecotoxicology and Environmental Safety
Produção Nacional
Revisado por pares
Francisca Janielle Barros, Raíra Justino Oliveira Costa, Francisco Rafael Alves Santana Cesário, Lindaiane Bezerra Rodrigues, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Hericka Bruna Figueiredo Galvão, Irwin Rose Alencar de Menezes,
Free radicals generated in vivo and peroxidation of the unsaturated bonds of membrane lipids increases fragility and cellular lysis of red blood cells. The essential oils of Piper aduncum and Cinnamomum zeylanicum present antioxidant activity and are popular in some countries to treat gastrointestinal diseases and anxiolytic symptoms respectively. Osmotic fragility assays and morphometric analyses have been used to assess cytotoxic effects and to verify the interaction of compounds present in the ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2016 - Elsevier BV | European Journal of Integrative Medicine
Produção Nacional
Revisado por pares
Carla de Fátima Alves Nonato, Débora Odília Duarte Leite, Rafael Caldas Pereira, Aline Augusti Boligon, Jaime Ribeiro‐Filho, Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa,
Background Fruit consumption is currently considered beyond the nutritional aspects because of the important roles in disease prevention and benefits to health. The objective of this study was to characterize the chemical profile and evaluate the antioxidant and antimicrobial properties of different fractions obtained from fruit pulps of Mauritia flexuosa (MFFs). Methods Initially, chloroform, ethyl acetate and ethanol fractions were obtained from the pulps. Quantifications of total phenols and flavonoids ...
Tópico(s): Natural product bioactivities and synthesis
2018 - PeerJ, Inc. | PeerJ
Produção Nacional
Revisado por pares
Delmácia Gonçalves de Macêdo, Marta Maria de Almeida Souza, Maria Flaviana Bezerra Morais‐Braga, Henrique Douglas Melo Coutinho, Antônia Thassya Lucas dos Santos, Antônio Júdson Targino Machado, Fábio Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes,
The present study aimed to investigate the influence of seasonality from different collection periods on the chemical composition and antifungal activity of the Psidium myrtoides O. Berg essential oil (OEFPm). The OEFPm chemical composition was evaluated through gas chromatography coupled to mass spectrometry (GC/MS). The oil's antifungal activity against species from the Candida genus, in isolation and in combination with Fluconazole at a subinhibitory concentration (MFC/16), was evaluated using the ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2019 - Elsevier BV | South African Journal of Botany
Zita Carvalho-Santos, Pedro Machado, Pedro Branco, Filipe Tavares-Cadete, Ana Rodrigues-Martins, José B. Pereira‐Leal, Mónica Bettencourt‐Dias,
The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential component of the centrosome, underlying eukaryotic microtubule-based motility, cell division and polarity. In recent years, components of the CBB-assembly machinery have been identified, but little is known about their regulation and evolution. Given the diversity of cellular contexts encountered in eukaryotes, but the remarkable conservation of CBB morphology, we asked whether general mechanistic principles ...
Tópico(s): Protist diversity and phylogeny
2010 - The Company of Biologists | Journal of Cell Science
Produção Nacional
Revisado por pares
Guilherme Janson, Graziela De Luca Canto, Décio Rodrigues Martins, José Fernando Castanha Henriques, Marcos Roberto de Freitas,
Abstract Apical root resorption is an undesirable, but frequent side effect of orthodontic treatment, and therefore improvements in orthodontic techniques and materials are in constant development to decrease it. One of the most recently developed orthodontic techniques is the Bioefficient Therapy that uses contemporary orthodontic materials. Therefore, the primary objective of this study was to compare the amount of root resorption after orthodontic treatment between the simplified standard edgewise technique ( ...
Tópico(s): dental development and anomalies
2000 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Rosana Campos do Vale, Maria Paula Jansen Rodrigues, José Manoel Martins,
Na produção do queijo Minas artesanal do Serro são utilizados leite cru, coalho e fermento lático natural, designado de “pingo”. Alguns produtores da região do Serro, fazem uso da “rala”, parte ralada do próprio queijo artesanal, com 3 a 5 dias de fabricação, que é adicionada ao leite em substituição ao “pingo”. Sabendo-se que condições controladas de umidade relativa do ar (UR) e temperatura também podem influenciar as características dos queijos durante a maturação. O objetivo deste trabalho foi avaliar ...
Tópico(s): Culinary Culture and Tourism
2018 - Empresa de Pesquisa Agropecuária de Minas Gerais | Revista do Instituto de Latícinios Cândido Tostes
Produção Nacional
Revisado por pares
Suellen Teixeira Nobre Gonçalves, Francisco das Chagas Vasconcelos Júnior, Cleiton da Silva Silveira, Daniel Antônio Camelo Cid, Eduardo Sávio Passos Rodrigues Martins, José Micael Ferreira da Costa,
The purpose of this work is to evaluate the applicability of five drought indices (Surface Water Supply Index—SWSI, Reclamation Drought Index—RDI, Streamflow Drought Index—SDI, Standardized Precipitation Index—SPI, and Evaporative Demand Drought Index—EDDI) as tools for monitoring, in identifying the duration, intensity, and frequency of hydrological droughts in the basins of the Banabuiú, Castanhão, and Orós reservoirs, located in the state of Ceará, Brazil. The analysis focused on determining the ...
Tópico(s): Hydrology and Watershed Management Studies
2023 - Multidisciplinary Digital Publishing Institute | Water
Produção Nacional
Revisado por pares
José Luís Rodrigues Martins, Oscar Romero Lopes Rodrigues, Dayane Moreira da Silva, Pablinny Moreira Galdino, José Realino de Paula, Wanderson Romão, Helber B. Costa, Boniek G. Vaz, Paulo César Ghedini, Élson Alves Costa,
Celtis iguanaea (Canabaceae) is popularly known as esporão-de-galo, stands out among the medicinal plants used for treatment of gastric ulcers. In Brazil, the leaves they are used traditionally in infusion forms as an analgesic, antiasthmatic, digestive and diuretic. The present study was aimed to investigate the antiulcer mechanisms of hexane extract Celtis iguanaea leaves (HE) in several induced-gastric ulcer and characterize its chemical composition. The HE was obtained by exhaustive extraction ...
Tópico(s): Advances in Cucurbitaceae Research
2014 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Claudio Vidal, Erlânio Oliveira de Sousa, Fabíola Rodrigues, Adriana Campos, Sírleis Rodrigues Lacerda, José Galberto Martins da Costa,
This work is the first to describe the modulation of antibiotic activity of the bryophyte Octoblepharum albidum Hedw extract. The antibacterial activity of ethanolic extract of O. albidum (EEOa), alone and in association with aminoglycosides, was determined against six bacterial strains by a microdilution test. The results showed a similar inhibitory activity of EEOa against Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 33018 (MICs 512 ?g/mL). The synergistic effect of the extracts and ...
Tópico(s): Botany and Plant Ecology Studies
2012 - University of Belgrade, University of Novi Sad | Archives of Biological Sciences
Produção Nacional
Revisado por pares
Marília Brasil Xavier, Fernando Tobias Sílveira, Sâmia Demachki, Márcia Milene Rodrigues Ferreira, José Luíz Martins do Nascimento,
A quantitative study was conducted on the density of Langerhans cells (LCs) CD1a+ in specimens obtained from patients with American tegumentary leishmaniasis (ATL) lesions without previous treatment, as well as from control healthy individuals. LC density was significantly higher among infected patients when compared to controls and also higher in longer term ones. Regarding parasite quantities, these were proportionally inverse and diminished in chronic patients. Localized cutaneous leishmaniasis ( ...
Tópico(s): Eosinophilic Disorders and Syndromes
2005 - Elsevier BV | Acta Tropica
Produção Nacional
Revisado por pares
Reginaldo Brito da Costa, Marcos Deon Vilela de Resende, Adriana Zanirato Contini, Flávio Luiz Hilário Rego, Raul Alffonso Rodrigues Roa, Wagner José Martins,
O presente estudo objetivou estimar parâmetros e valores genéticos para os caracteres altura e diâmetro de indivíduos de erva-mate Ilex paraguariensis (St. Hil.) pela metodologia de modelos mistos (procedimento REML/BLUP). As progênies de meios-irmãos foram plantadas na Reserva Indígena Kaiowá e Guarani, em Caarapó/MS, sob delineamento de blocos ao acaso, com seis tratamentos (progênies), seis repetições e vinte plantas por parcela. Aos 9 meses de idade, foram avaliados os caracteres: altura total ...
Tópico(s): Agricultural and Food Sciences
2005 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Florestal
Produção Nacional
Revisado por pares
Valter Menezes Barbosa Filho, Emily Pansera Waczuk, Jean Paul Kamdem, Amos O. Abolaji, Sírleis Rodrigues Lacerda, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Aline Augusti Boligon, Margareth Linde Athayde, João Batista Teixeira da Rocha, Thaís Posser,
Anacardium microcarpum is consumed as infusion in the Brazilian folk medicine for the treatment of various diseases in which free radicals assaults have been implicated in their etiology. However, there is no scientific report on this traditional claim. Thus, we investigated for the first time, its antioxidant activity as well as its potential toxic effects on human leukocytes and erythrocytes in vitro. In addition, qualitative and quantitative analyses of the classes of phytochemicals in the various ...
Tópico(s): Antioxidants, Aging, Portulaca oleracea
2014 - Elsevier BV | Industrial Crops and Products
Pedro F. Lisboa, Ana Rita Rodrigues, José Luis Fernández Martín, Pedro Simões, Susana Barreiros, Alexandre Paiva,
Enzymatic transesterification is becoming a commercially competitive route to biodiesel. Supercritical CO2 (scCO2) is well established as a solvent for extraction processes. Here we analyze the economy of a scCO2-based, enzymatic process, for the production of biodiesel from waste cooking sunflower oil (WCO). The conversion of WCO to fatty acid ethyl esters (FAEE) catalyzed by immobilized lipase from Thermomyces lanuginosus (Lipozyme TL IM), and downstream separation to recover biodiesel conforming ...
Tópico(s): Enzyme Catalysis and Immobilization
2013 - Elsevier BV | The Journal of Supercritical Fluids
José Rodrigues Pereira, Sandro José Martins, F.K Ikari, S.M Nikaedo, O. Gampel,
Tópico(s): Radiation Therapy and Dosimetry
1999 - Elsevier BV | European Journal of Cancer
Produção Nacional
Revisado por pares
Josineide Pantoja da Costa, Ana Paula Rodrigues, Luis Henrique S. Farias, Paula Cristina Rodrigues Frade, Bruno José Martins da Silva, José Luíz Martins do Nascimento, Edilene O. Silva,
Monocytes are mononuclear phagocytes in peripheral blood that can differentiate into macrophages and dendritic cells. Macrophages play a specific role in the inflammatory process and are essential for the innate response. Given the important role of monocytes/macrophages in the immune response, this study aimed to evaluate the activity of kojic acid (KA), a natural product of certain fungal species, on human peripheral blood monocytes in vitro. Purified monocytes isolated from human blood were incubated ...
Tópico(s): Glycosylation and Glycoproteins Research
2018 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Maria Elena Crespo‐López, Ericks Sousa Soares, Barbarella de Matos Macchi, Letícia Santos-Sacramento, Priscila Y. Takeda, Amanda Lopes-Araújo, Ricardo Sousa de Oliveira Paraense, José Rogério Souza Monteiro, Marcus Augusto‐Oliveira, Diandra Araújo Luz, Cristiane do Socorro Ferraz Maia, Hervé Rogez, Marcelo de Oliveira Lima, João Paulo Góes Pereira, Diomar Cavalcante Oliveira, Rommel Mário Rodríguez Burbano, Rafael Rodrigues Lima, José Luíz Martins do Nascimento, Gabriela de Paula Arrifano,
Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 μL/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical ( ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2019 - Multidisciplinary Digital Publishing Institute | Nutrients
Produção Nacional
Revisado por pares
Louise Buonalumi Tácito Yugar, Juan Carlos Yugar‐Toledo, N Ludovico, Luis Gustavo Sedenho-Prado, Beatriz Moreno, Tatiane de Azevedo Rubio, André Fattori, Bruno Rodrigues, José Fernando Vilela-Martin, Heitor Moreno,
Cardiac innervation by the parasympathetic nervous system (PNS) and the sympathetic nervous system (SNS) modulates the heart rate (HR) (chronotropic activity) and the contraction of the cardiac muscle (inotropic activity). The peripheral vasculature is controlled only by the SNS, which is responsible for peripheral vascular resistance. This also mediates the baroreceptor reflex (BR), which in turn mediates blood pressure (BP). Hypertension (HTN) and the autonomic nervous system (ANS) are closely related, ...
Tópico(s): Heart rate and cardiovascular health
2023 - Multidisciplinary Digital Publishing Institute | Diagnostics
Produção Nacional
Revisado por pares
Maria Elena Crespo‐López, Gabriela de Paula Arrifano, Marcus Augusto‐Oliveira, Barbarella de Matos Macchi, Rafael Rodrigues Lima, José Luíz Martins do Nascimento, Carlos Barbosa Alves de Souza,
Amazon conservation is essential for the global future. Mercury is currently among the worst global pollutants and most (78.5%) of the South-American emissions are from the Amazon. Current Brazilian legislation on mining activities and trade of gold, and economic interests in soy, beef and large-scale projects such as dams, are key influences in mercury mobilization and emissions in the Amazon with the potential to affect the global environment. However, banning mercury in mining, while desirable, ...
Tópico(s): Fish biology, ecology, and behavior
2023 - Elsevier BV | Ecotoxicology and Environmental Safety