Manuel D. Gahete, Mercedes del Río-Moreno, Antonio Camargo, Juan F. Alcalá‐Díaz, Emilia Alors‐Pérez, Javier Delgado‐Lista, Óscar Reyes, Sebastián Ventura, Pablo Pérez‐Martínez, Justo P. Castaño, José López‐Miranda, Raúl M. Luque,
BackgroundType-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, we hypothesized that dysregulations in splicing machinery could precede, contribute to, and predict T2DM development.MethodsA cohort of patients with cardiovascular disease (CORDIOPREV study) and without T2DM at baseline (at the inclusion of the study) was used (n = 215). We determined ...
Tópico(s): RNA modifications and cancer
2018 - Elsevier BV | EBioMedicine
Manuel D. Gahete, Raúl M. Luque, Elena M. Yubero‐Serrano, Cristina Cruz‐Teno, Alejandro Ibáñez‐Costa, Javier Delgado‐Lista, Francisco Gracia‐Navarro, Francisco Pérez‐Jiménez, Justo P. Castaño, José López‐Miranda,
Dietary fat influences systemic inflammatory status, which determines the progression of age-associated diseases. Since somatostatin (SST), cortistatin (CORT), and ghrelin systems modulate inflammatory response, we aim to comprehensively characterize the presence and regulation of the components of these systems in the peripheral blood mononuclear cells (PMBCs), a subset of white blood cells placed at the crossroad between diet and inflammation, in response to diets with different fat composition, ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2014 - Wiley | Molecular Nutrition & Food Research
Vicente Herrero‐Aguayo, Juan M. Jiménez‐Vacas, Prudencio Sáez-Martínez, Enrique Gómez‐Gómez, Juan L López-Cánovas, Lourdes Garrido‐Sánchez, Aura D. Herrera‐Martínez, Laura García‐Bermejo, Manuel Macías‐González, José López‐Miranda, Justo P. Castaño, Manuel D. Gahete, Raúl M. Luque,
Obesity is a major health problem associated with severe comorbidities, including type 2 diabetes and cancer, wherein microRNAs (miRNAs) might be useful as diagnostic/prognostic tools or therapeutic targets.To explore the differential expression pattern of miRNAs in obesity and their putative role in obesity-related comorbidities such as insulin resistance.An Affymetrix-miRNA array was performed in plasma samples from normoweight (n = 4/body mass index < 25) and obese subjects (n = 4/body mass index > 30). ...
Tópico(s): MicroRNA in disease regulation
2020 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Teresa Seruya, José Miranda Justo,
This book celebrates the bicentenary of Schleiermacher's famous Berlin conference "On the Different Methods of Translating" (1813). It is the product of an international Call for Papers that welcomed
Tópico(s): Classical Studies and Philology
2015 - Springer International Publishing | New frontiers in translation studies
Produção Nacional
Revisado por pares
Seruya, Teresa; Justo, José Miranda. Rereading Schleiermacher: Translation Cognition and Culture. Heidelberg: Springer-Verlag, 2016, 323 p.
Tópico(s): Historical Linguistics and Language Studies
2022 - UNIVERSIDADE FEDERAL DE SANTA CATARINA | Cadernos de Tradução
Francisco Gómez-Delgado, Javier Delgado‐Lista, Javier López-Moreno, Oriol A. Rangel‐Zúñiga, Juan F. Alcalá‐Díaz, Ana León-Acuña, Andreea Corina, Elena M. Yubero‐Serrano, José D. Torres‐Peña, Antonio Camargo, Antonio García‐Ríos, Javier Caballero‐Villarraso, Justo P. Castaño, José M. Ordovás, José López‐Miranda, Pablo Pérez‐Martínez,
Leukocyte telomere length (LTL) attrition has been associated with age-related diseases. Telomerase RNA Component (TERC) genetic variants have been associated with LTL; whereas fatty acids (FAs) can interact with genetic factors and influence in aging. We explore whether variability at the TERC gene locus interacts with FA profile and two healthy diets (low-fat diet vs Mediterranean diet [MedDiet]) modulating LTL, glucose metabolism, and inflammation status in coronary heart disease (CHD) patients. Inflammation ...
Tópico(s): Advanced Glycation End Products research
2016 - Oxford University Press | The Journals of Gerontology Series A
Raúl M. Luque, Laura M. López‐Sánchez, Alicia Villa-Osaba, Isabel M. Luque, Ana L. Santos-Romero, Elena M. Yubero‐Serrano, María Cara-García, Marina Álvarez Benito, José López‐Miranda, Manuel D. Gahete, Justo P. Castaño,
... 4, 6 , Marina Álvarez-Benito 1, 4, 6 , José López-Miranda 1, 4, 7 , Manuel D. Gahete 1, 2, 3, 4, 5, # and Justo P. Castaño 1, 2, 3, 4, 5, # 1 ...
Tópico(s): Cancer, Lipids, and Metabolism
2017 - Impact Journals LLC | Oncotarget
Cristina Vals‐Delgado, Juan F. Alcalá‐Díaz, Irene Roncero‐Ramos, Ana León-Acuña, Helena Molina‐Abril, Francisco M. Gutiérrez-Mariscal, Juan Luis Romero‐Cabrera, Silvia de la Cruz, Ben van Ommen, Justo P. Castaño, José M. Ordovás, Pablo Pérez‐Martínez, Javier Delgado‐Lista, Antonio Camargo, José López‐Miranda,
... Antonio Camargo, Irene Roncero-Ramos, Ben van Ommen, Justo P. Castaño, Jose M. Ordovas, Pablo Perez-Martinez, Javier Delgado-Lista, and Jose Lopez-Miranda contributed to the writing of the manuscript and ...
Tópico(s): Dietary Effects on Health
2021 - Springer Science+Business Media | Clinical and Translational Medicine
Enrique Gómez‐Gómez, Juan M. Jiménez‐Vacas, Julia Carrasco‐Valiente, Vicente Herrero‐Aguayo, Ana Blanca, Antonio J. León‐González, J. Valero-Rosa, José Luis Fernández-Rueda, Teresa González Serrano, José López‐Miranda, Manuel D. Gahete, Justo P. Castaño, M.J. Requena-Tapia, Raúl M. Luque,
Early detection of PCa faces severe limitations as PSA displays poor-specificity/sensitivity. As we recently demonstrated that plasma ghrelin O-acyltransferase (GOAT)-enzyme is significantly elevated in PCa-patients compared with healthy-controls, using a limited patients-cohort, we aimed to further explore the potential of GOAT to improve PCa diagnosis using an ample patients-cohort (n = 312) and defining subgroups (i.e. significant PCa/metastatic patients, etc.) that could benefit from this biomarker. ...
Tópico(s): Hormonal and reproductive studies
2018 - Wiley | Journal of Cellular and Molecular Medicine
Daniel Hormaechea‐Agulla, Enrique Gómez‐Gómez, Alejandro Ibáñez‐Costa, Julia Carrasco‐Valiente, Esther Rivero‐Cortés, Fernando L‐López, Sergio Pedraza‐Arévalo, J. Valero-Rosa, Rafael Sánchez‐Sánchez, Rosa Ortega‐Salas, María M. Moreno, Manuel D. Gahete, José López‐Miranda, M.J. Requena, Justo P. Castaño, Raúl M. Luque,
Ghrelin-O-acyltransferase (GOAT) is the key enzyme regulating ghrelin activity, and has been proposed as a potential therapeutic target for obesity/diabetes and as a biomarker in some endocrine-related cancers. However, GOAT presence and putative role in prostate-cancer (PCa) is largely unknown. Here, we demonstrate, for the first time, that GOAT is overexpressed (mRNA/protein-level) in prostatic tissues (n = 52) and plasma/urine-samples (n = 85) of PCa-patients, compared with matched controls [healthy prostate ...
Tópico(s): Regulation of Appetite and Obesity
2016 - Elsevier BV | Cancer Letters
Márcio Suzuki, Mario Spezzapria, Juliana Ferraci Martone,
... Georg Hamann. Tradução, notas, cronologia e posfácio de José Miranda Justo. Segunda edição revista e aumentada. Lisboa: Centro de ...
Tópico(s): Phenomenology and Existential Philosophy
2018 - | Estudos Kantianos [EK]
Manuel D. Gahete, José Córdoba‐Chacón, Daniel D. Lantvit, Rosa Ortega‐Salas, Rafael Sánchez‐Sánchez, Francisco Pérez‐Jiménez, José López‐Miranda, Steven M. Swanson, Justo P. Castaño, Raúl M. Luque, Rhonda D. Kineman,
Growth hormone (GH) and/or insulin-like growth factor I (IGF-I) are thought to promote breast cancer based on reports showing circulating IGF-I levels correlate, in epidemiological studies, with breast cancer risk. Also, mouse models with developmental GH/IGF-I deficiency/resistance are less susceptible to genetic- or chemical-induced mammary tumorigenesis. However, given the metabolic properties of GH, medical strategies have been considered to raise GH to improve body composition and metabolic function ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2014 - Oxford University Press | Carcinogenesis
Produção Nacional
José Miranda Justo foi Professor Associado na Faculdade de Letras da Universidade de Lisboa, encontrando-se presentemente na posição ...
Tópico(s): Medieval Iberian Studies
2021 - | Estudos Kantianos [EK]
Mercedes del Río-Moreno, Raúl M. Luque, Oriol A. Rangel‐Zúñiga, Emilia Alors‐Pérez, Juan F. Alcalá‐Díaz, Irene Roncero‐Ramos, Antonio Camargo, Manuel D. Gahete, José López‐Miranda, Justo P. Castaño,
Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is associated with the risk of T2DM development. Thus, the aim of this work was to evaluate the influence of 3-year dietary intervention in the expression pattern of the splicing machinery ...
Tópico(s): RNA and protein synthesis mechanisms
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Rosa Jiménez-Lucena, Oriol A. Rangel‐Zúñiga, Juan F. Alcalá‐Díaz, Javier López-Moreno, Irene Roncero‐Ramos, Helena Molina‐Abril, Elena M. Yubero‐Serrano, Javier Caballero‐Villarraso, Javier Delgado‐Lista, Justo P. Castaño, José M. Ordovás, Pablo Pérez‐Martínez, Antonio Camargo, José López‐Miranda,
Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than the currently used tools. Our aim was to identify whether circulating miRNAs, added to clinical and biochemical markers, yielded better potential for predicting type 2 diabetes. The study included 462 non-diabetic patients at baseline in the CORDIOPREV study. After a median follow-up of 60 months, 107 of them developed type 2 diabetes. Plasma ...
Tópico(s): Cancer-related molecular mechanisms research
2018 - Cell Press | Molecular Therapy — Nucleic Acids
Preview this article: Seruya, Teresa, and Justo, (eds) (2016). Rereading Schleiermacher: Translation, Cognition and Culture, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/babel.63.2.13liu-1.gif
Tópico(s): Historical Linguistics and Language Studies
2017 - John Benjamins Publishing Company | Babel Revue internationale de la traduction / International Journal of Translation / Revista Internacional de Traducción
Elena M. Yubero‐Serrano, Carolina Fernández-Gandara, Antonio García‐Ríos, Oriol A. Rangel‐Zúñiga, Francisco M. Gutiérrez-Mariscal, José D. Torres‐Peña, Carmen Marı́n, Javier López-Moreno, Justo P. Castaño, Javier Delgado‐Lista, José M. Ordovás, Pablo Pérez‐Martínez, José López‐Miranda,
Background Endothelial dysfunction is a crucial step in atherosclerosis development, and its severity is determinant for the risk of cardiovascular recurrence. Diet may be an effective strategy to protect the endothelium, although there is no consensus about the best dietary model. The CORonary Diet Intervention with Olive oil and cardiovascular PREVention (CORDIOPREV) study is an ongoing prospective, randomized, single-blind, controlled trial in 1,002 coronary heart disease (CHD) patients, whose ...
Tópico(s): Nutritional Studies and Diet
2020 - Public Library of Science | PLoS Medicine
Francisco M. Gutiérrez-Mariscal, Pablo Pérez‐Martínez, Javier Delgado‐Lista, Elena M. Yubero‐Serrano, Antonio Camargo, Nieves Delgado‐Casado, Cristina Cruz‐Teno, Mónica Santos‐González, Fernando Rodríguez-Cantalejo, Justo P. Castaño, J.M. Villalba-Montoro, Francisco Fuentes, Francisco Pérez‐Jiménez, José López‐Miranda,
Tópico(s): Folate and B Vitamins Research
2011 - Springer Science+Business Media | AGE
Irene Roncero‐Ramos, Oriol A. Rangel‐Zúñiga, Javier López-Moreno, Juan F. Alcalá‐Díaz, Pablo Pérez‐Martínez, Rosa Jiménez-Lucena, Justo P. Castaño, Helen M. Roche, Javier Delgado‐Lista, José M. Ordovás, Antonio Camargo, José López‐Miranda,
Scope Insulin resistance (IR) and chronic low‐grade inflammation are hallmarks of type 2 diabetes mellitus (T2DM). The “NOD‐like receptor pyrin domain containing‐3” (NLRP3) inflammasome component of innate immunity is a metabolic stress sensor modulated by dietary and genetics factors. The aim of this study was to evaluate the effects of the consumption of two diets for 3 years, Mediterranean (Med) and low fat, on glucose homeostasis in the 1002 coronary heart disease patients of the CORDIOPREV study, ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2018 - Wiley | Molecular Nutrition & Food Research
Mercedes del Río-Moreno, Emilia Alors‐Pérez, Sandra González‐Rubio, Gustavo Ferrín, Óscar Reyes, Manuel Rodríguez‐Perálvarez, Marina Sánchez‐Frías, Rafael Sánchez‐Sánchez, Sebastián Ventura, José López‐Miranda, Rhonda D. Kineman, Manuel de la Mata, Justo P. Castaño, Manuel D. Gahete, Raúl M. Luque,
Nonalcoholic fatty liver disease (NAFLD) is a common obesity-associated pathology characterized by hepatic fat accumulation, which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma. Obesity is associated with profound changes in gene-expression patterns of the liver, which could contribute to the onset of comorbidities. As these alterations might be linked to a dysregulation of the splicing process, we aimed to determine whether the dysregulation in the expression of splicing machinery ...
Tópico(s): RNA modifications and cancer
2019 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Alicia Villa-Osaba, Manuel D. Gahete, José Córdoba‐Chacón, Luı́s de Lecea, Ana I. Pozo-Salas, Javier Delgado‐Lista, Marina Álvarez Benito, José López‐Miranda, Raúl M. Luque, Justo P. Castaño,
Locally produced growth hormone (GH) and IGF-I are key factors in the regulation of mammary gland (MG) development and may be important in breast cancer development/progression. Somatostatin (SST) and cortistatin (CORT) regulate GH/IGF-I axis at various levels, but their role in regulating GH/IGF-I in MGs remains unknown. Since obesity alters the expression of these systems in different tissues and is associated to MG (patho) physiology, we sought to investigate the role of SST/CORT in regulating GH/ ...
Tópico(s): Regulation of Appetite and Obesity
2015 - Public Library of Science | PLoS ONE
Juan M. Jiménez‐Vacas, Enrique Gómez‐Gómez, Antonio J. Montero‐Hidalgo, Vicente Herrero‐Aguayo, Fernando L‐López, Rafael Sánchez‐Sánchez, Ipek Guler, Ana Blanca, María José Méndez-Vidal, Julia Carrasco‐Valiente, José López‐Miranda, M.J. Requena-Tapia, Justo P. Castaño, Manuel D. Gahete, Raúl M. Luque,
Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/aggressiveness capacity of GOAT in urine, as well as to interrogate its putative pathophysiological role in PCa. We analysed urine/plasma levels of GOAT in a cohort of 993 patients. In vitro (i.e., cell-proliferation) and in vivo (tumor-growth in a xenograft-model) approaches were performed ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Produção Nacional
... Álvaro Valls. Petrópolis: Vozes, 1995. (Ou: Tradução de José Miranda Justo. Lisboa: Relógio D’Água, 2012.)_______. In Vino Veritas. Tradução de José Miranda Justo. Lisboa: Antígona, 2005.KIERKEGAARD, Søren A. Ou – Ou: ...
Tópico(s): Literary and Philosophical Studies
2018 - | Trilhas Filosóficas
... civil de resultados 5. a proposta do Min. Jose Augusto Delgado 6. o Supremo Tribunal Federal e a garantia do justo valor 7. de Pontes de Miranda a Humberto Theodoro Junior 8. Eduardo Couture 9. ...
Tópico(s): Legal principles and applications
2001 - PONTIFÍCIA UNIVERSIDADE CATÓLICA DE MINAS GERAIS | Revista da Faculdade Mineira de Direito
Giuseppina Maria Cardella, Brizeida Raquel Hernández-Sánchez, João Manuel Rosado de Miranda Justo, José Carlos Sánchez García,
Social entrepreneurship is a research topic that has received great attention from academics especially in recent years. However, the results in the literature are far from univocal, for example, there is no clear conceptual delimitation of the term, and it is often analyzed using the same theoretical models of traditional entrepreneurship. With the present study, we have attempted to overcome this problem by analyzing different antecedents, closer to the social and emotional universe, and detached ...
Tópico(s): Innovation and Socioeconomic Development
2023 - Routledge | Studies in Higher Education
Produção Nacional
Revisado por pares
Raquel Rodrigues Barbieri, Anna Maria Sales, Ximena Illarramendi, Milton Ozório Moraes, José Augusto da Costa Nery, Suelen Justo Maria Moreira, Euzenir Nunes Sarno, Alice de Miranda Machado, Fernando A. Bozza,
The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). Mycobacterium leprae-specific genes were detected using qPCR. The biopsies of 47 out of 57 clinically diagnosed patients who received multidrug therapy ...
Tópico(s): Infectious Diseases and Tuberculosis
2014 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Raúl M. Luque, Alicia Villa-Osaba, Fernando L‐López, Ana I. Pozo-Salas, Rafael Sánchez‐Sánchez, Rosa Ortega‐Salas, Luı́s de Lecea, Marina Álvarez Benito, José López‐Miranda, Manuel D. Gahete, Justo P. Castaño,
Somatostatin (SST) and cortistatin (CORT), two structurally and functionally related peptides, share a family of widespread receptors (sst1-5) to exert apparently similar biological actions, including endocrine/metabolic regulation and suppression of tumor cell proliferation. However, despite their therapeutic potential, attempts to apply SST-analogs to treat breast cancer have yielded unsatisfactory results. Actually, the specific roles of SST and CORT in mammary gland tumorigenesis (MGT), particularly ...
Tópico(s): Pituitary Gland Disorders and Treatments
2016 - BioMed Central | Breast Cancer Research
... Repetição: um ensaio em psicologia experimental. Tradução de José Miranda Justo. Lisboa: Relógio D’Água Editores, 2009a._______. O Desespero ...
Tópico(s): Literary and Philosophical Studies
2018 - | Trilhas Filosóficas
... Carvalho, Lisboa: Assirio Alvim, 2007a. _____. A Repetição, trad. José Miranda Justo, Lisboa: Relógio D'Água Editores, 2009a._____. Migalhas filosóficas -- ...
Tópico(s): Memory, Trauma, and Testimony
2016 - | Ítaca
Produção Nacional
... Trotta, 2007a, p. 147-297._____. A Repetição. Trad. José Miranda Justo. Lisboa: Relógio D'Água Editores, 2009._____. Temor e ...
Tópico(s): Literary and Philosophical Studies
2016 - | Ítaca