
María Montes de, Rogelio Pérez‐Padilla, Carlos Tálamo, Ronald J. Halbert, Dolores Moreno, María Victorina López, Adriana Muiño, B. Jardim José Roberto, Gonzalo Valdívia, Julio A. Pertuzé, B. Menezes Ana Maria,
Acute bronchodilator responsiveness is an area of discussion in COPD. No information exists regarding this aspect of the disease from an unselected COPD population. We assessed acute bronchodilator responsiveness and factors influencing it in subjects with and without airway obstruction in an epidemiologic sample.COPD was defined by GOLD criteria (post-bronchodilator FEV(1)/FVC<0.70). In this analysis, subjects with pre-bronchodilator FEV(1)/FVC or =0.70 post-bronchodilator were considered to have ...
Tópico(s): Asthma and respiratory diseases
2009 - Elsevier BV | Pulmonary Pharmacology & Therapeutics

Dulcilene Pereira Jardim, José Roberto da Silva Brêtas,
A escola exerce um importante papel na orientação sexual durante a adolescência. Este estudo teve como objetivo identificar o conhecimento e a atuação em sexualidade dos professores de ensino fundamental e médio. Trata-se de um estudo exploratório-descritivo, cujos dados foram obtidos por meio de um questionário, respondido por 100 professores da rede de ensino público do município de Jandira, SP. Os resultados demonstraram que, apesar de considerarem a importância do tema, a maioria dos professores ...
Tópico(s): Youth, Drugs, and Violence
2006 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem

Pedro S. Fadini, Wilson F. Jardim, José Roberto Guimarães,
Biochemical Oxygen Demand (BOD) and Chemical Oxygen Demand (COD) are the major parameters used as routine surrogate tests for measuring the load of organic carbon into the environment. In this context, an evaluation of possible replacement of BOD and COD for Dissolved Organic Carbon (DOC) measurements are presented for different wastewaters. For anaerobic pond effluent, the following correlations were obtained: COD = 1.08 DOC + 79 and BOD = 0.82 DOC + 12. For facultative pond effluent, COD = -0.29DOC + 109 and ...
Tópico(s): Water Quality Monitoring Technologies
2004 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society

Germán Peces‐Barba, Joan Albert Barberà, Àlvar Agustí, Ciro Casanova, Alejandro Casas, José Luís Izquierdo Alonso, José Roberto Jardim, Victorina López Varela, Eduard Monsó, Teodoro Montemayor, José Luís Viejo,
Puntos clave: – La enfermedad pulmonar obstructiva cronica (EPOC) se caracteriza por la presencia de obstruccion cronica y poco reversible al flujo aereo, que se asocia a una reaccion inflamatoria anomala, principalmente frente al humo del tabaco. – La obstruccion al flujo aereo se define por la espirometria cuando el cociente volumen espiratorio forzado en el primer segundo/capacidad vital forzada (FEV1/FVC) tras broncodilatacion es menor de 0,7 (o por debajo del limite inferior de la normalidad en personas ...
Tópico(s): Respiratory Support and Mechanisms
2008 - Elsevier BV | Archivos de Bronconeumología

Frederico Leon Arrabal Fernandes, Alberto Cukier, Aquiles Assunção Camelier, Carlos Cézar Fritscher, Cláudia Henrique da Costa, Eanes Delgado Barros Pereira, Irma Godoy, José Eduardo Delfini Cançado, João Hamilton Romaldini, José Miguel Chatkin, José Roberto Jardim, Marcelo Fouad Rabahi, Maria Cecília Nieves Maiorano de Nucci, Maria da Penha Uchoa Sales, Maria Vera Cruz de Oliveira Castellano, Miguel Abidon Aidê, Paulo José Zimermann Teixeira, Renato Anatolio Lima Horta Maciel, Ricardo de Amorim Corrêa, Roberto Stirbulov, Rodrigo Abensur Athanazio, Rodrigo Russo, Suzana Érico Tanni, Fernando Luiz Cavalcanti Lundgren,
ABSTRACT The treatment of COPD has become increasingly effective. Measures that range from behavioral changes, reduction in exposure to risk factors, education about the disease and its course, rehabilitation, oxygen therapy, management of comorbidities, and surgical and pharmacological treatments to end-of-life care allow health professionals to provide a personalized and effective therapy. The pharmacological treatment of COPD is one of the cornerstones of COPD management, and there have been ...
Tópico(s): Asthma and respiratory diseases
2017 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

Germán Peces‐Barba, Joan Albert Barberà, Àlvar Agustí, Ciro Casanova, Alejandro Casas, José Luís Izquierdo Alonso, José Roberto Jardim, Victorina López Varela, Eduard Monsó, Teodoro Montemayor, José Luís Viejo,
Clinical practice guidelines have been shown to be valuable tools for guiding medical decisions. However, their mere publication has not reduced the variability of practice in terms of the way acute bronchiolitis is managed.A before-and-after study design was used to analyse the effectiveness of a method of disseminating diagnostic recommendations among physicians regarding the management of infants, hospitalised due to bronchiolitis. Patients with comorbidities, ex-premature patients, and patients ...
Tópico(s): Pleural and Pulmonary Diseases
2008 - Elsevier BV | Archivos de Bronconeumología

Rogelio Pérez‐Padilla, María Montes de, Ireri Thirión-Romero, Fernando C. Wehrmeister, María Victorina López, Gonzalo Valdívia, José Roberto Jardim, Adriana Muiño, Ana Maria Baptista Menezes,
Preserved ratio impaired spirometry (PRISm) has been associated with adverse outcomes and increased transition to other spirometric categories over time. We aimed to examine its prevalence, trajectories over time, and outcomes in a population-based sample from Latin America.Data were obtained from two population-based surveys of adults from three cities in Latin America (PLATINO study), conducted on the same individuals 5-9 years after their baseline examination. We estimated the frequency of PRISm ...
Tópico(s): Respiratory Support and Mechanisms
2023 - Dove Medical Press | International Journal of COPD

José Roberto Jardim, Francisco Maldonado, Frederico Leon Arrabal Fernandes, Maria Vera Cruz de Oliveira Castellano, María Torres‐Durán, Marc Miravitlles,
Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder caused by a mutation in the SERPINA1 gene, which encodes the protease inhibitor alpha-1 antitrypsin (AAT). Severe AATD predisposes individuals to COPD and liver disease. Early diagnosis is essential for implementing preventive measures and limiting the disease burden. Although national and international guidelines for the diagnosis and management of AATD have been available for 20 years, more than 85% of cases go undiagnosed and therefore ...
Tópico(s): Peptidase Inhibition and Analysis
2021 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

Rodrigo Russo, Laura Russo Zillmer, Oliver A. Nascimento, Beatriz Martins Manzano, Ivan Ivanaga, Leandro Genehr Fritscher, Fernando Luiz Cavalcanti Lundgren, Marc Miravitlles, Heicilainy Del Carlos Gondim, Gildo Santos, Marcela Amorim Alves, Maria Vera Cruz de Oliveira, Altay Alves Lino de Souza, Maria Penha Uchoa Sales, José Roberto Jardim,
ABSTRACT Objective: To determine the prevalence of alpha 1-antitrypsin (AAT) deficiency (AATD), as well as allele frequency, in COPD patients in Brazil. Methods: This was a cross-sectional study involving 926 COPD patients 40 years of age or older, from five Brazilian states. All patients underwent determination of AAT levels in dried blood spot (DBS) samples by nephelometry. Those with DBS AAT levels ≤ 2.64 mg/dL underwent determination of serum AAT levels. Those with serum AAT levels of < 113 mg/dL underwent ...
Tópico(s): Healthcare Regulation
2016 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

Felipe Cortopassi, Antônio Adolfo Mattos de Castro, Elias Ferreira Pôrto, Marcelo Colucci, Giulliana Iafrate Da Fonseca, Luis Torre‐Bouscoulet, Vinícius C. Iamonti, José Roberto Jardim,
Background. Comprehensive exercise training (CET) is an efficient strategy to decrease dyspnea perception in chronic obstructive pulmonary disease (COPD) and may result in significant improvement in ventilatory muscles function. Our aim was to evaluate the effects of general exercise training on dyspnea perception and on respiratory muscles strength in COPD patients. Methods. Consecutive COPD patients were enrolled to complete a CET programme. The patients underwent a routine that included a global ...
Tópico(s): Respiratory Support and Mechanisms
2016 - PAGEPress (Italy) | Monaldi Archives for Chest Disease

Elias Ferreira Pôrto, Antônio Adolfo Mattos de Castro, Marcelo Velloso, Oliver A. Nascimento, Fabien Dal Maso, José Roberto Jardim,
mandatory constituents of a rehabilitation programme for patients with COPD. However, it is not known how much these exercises may induce pulmonary dynamic hyperinflation (DH). Objective. To evaluate the DH in patients with COPD exercising the upper and lower parts of the body at the same metabolic demand. Methods. Sixteen patients aged 63 ± 13 years and with a FEV1 of 1.5 ± 0.7 L (41 ± 11% pred) were studied. Patients initially performed a maximal exercise test with the arms using the diagonal movement ...
Tópico(s): Cardiovascular and exercise physiology
2016 - PAGEPress (Italy) | Monaldi Archives for Chest Disease

Alejandro Casas Herrera, María Montes de, María Victorina López Varela, Carlos Aguirre, Eduardo Schiavi, José Roberto Jardim,
Background Acknowledgement of COPD underdiagnosis and misdiagnosis in primary care can contribute to improved disease diagnosis. PUMA is an international primary care study in Argentina, Colombia, Venezuela and Uruguay. Objectives To assess COPD underdiagnosis and misdiagnosis in primary care and identify factors associated with COPD underdiagnosis in this setting. Methods COPD was defined as post-bronchodilator (post-BD) forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) <0.70 and ...
Tópico(s): Emergency and Acute Care Studies
2016 - Public Library of Science | PLoS ONE

Rogelio Pérez‐Padilla, Fernando C. Wehrmeister, María Montes de, María Victorina López, José Roberto Jardim, Adriana Muiño, Gonzalo Valdívia, Julio A. Pertuzé, Ana Maria B. Menezes,
Background A low FEV1/FVC from post-bronchodilator spirometry is required to diagnose COPD. Both the FEV1 and the FVC can vary over time; therefore, individuals can be given a diagnosis of mild COPD at one visit, but have normal spirometry during the next appointment, even without an intervention. Methods We analyzed two population-based surveys of adults with spirometry carried out for the same individuals 5-9 years after their baseline examination. We determined the factors associated with a change ...
Tópico(s): Respiratory and Cough-Related Research
2015 - Public Library of Science | PLoS ONE

Nívia L. Nonato, Orlando Díaz, Oliver A. Nascimento, Jorge Dreyse, José Roberto Jardim, Carmen Lisboa,
To evaluate if the association between the BODE index and deterioration in health-related quality of life is linear. To determine possible associations between the BODE index and health status evaluated by the Saint George's Respiratory Questionnaire (SGRQ) at all levels of disease severity in COPD. A cross-sectional study was carried out on 253 patients from two Latin American respiratory centers (Brazil and Chile) with a clinical diagnosis of COPD, based on GOLD criteria. Assessment included the ...
Tópico(s): Respiratory Support and Mechanisms
2015 - Elsevier BV | Archivos de Bronconeumología

Cláudia S Silva, Fabiana Ribeiro Nogueira, Elias Ferreira Pôrto, Mariana Rodrigues Gazzotti, Oliver A. Nascimento, Aquiles Assunção Camelier, José Roberto Jardim,
The objective of this study was to investigate whether some activities of daily living (ADLs) usually related to dyspnea sensation in patients with chronic obstructive pulmonary disease (COPD) are associated with dynamic lung hyperinflation (DH) and whether the use of simple energy conservation techniques (ECTs) might reduce this possible hyperinflation. Eighteen patients (mean age: 65.8 ± 9.8 years) with moderate-to-severe COPD performed six ADLs (walking on a treadmill, storing pots, walking 56 meters ...
Tópico(s): Heart Rate Variability and Autonomic Control
2015 - SAGE Publishing | Chronic Respiratory Disease

María Montes de, María Victorina López Varela, Agustín Acuña, Eduardo Schiavi, María Alejandra Rey, José Roberto Jardim, Alejandro Casas, Antonio Tokumoto, Carlos A. Torres‐Duque, Alejandra Ramírez‐Venegas, Gabriel García, Roberto Stirbulov, Aquiles Assunção Camelier, Miguel Bergna, Mark E. Cohen, Santiago V. Guzmán, Efraín Sánchez,
ALAT-2014 COPD Clinical Practice Guidelines used clinical questions in PICO format to compile evidence related to risk factors, COPD screening, disease prognosis, treatment and exacerbations. Evidence reveals the existence of risk factors for COPD other than tobacco, as well as gender differences in disease presentation. It shows the benefit of screening in an at-risk population, and the predictive value use of multidimensional prognostic indexes. In stable COPD, similar benefits in dyspnea, pulmonary ...
Tópico(s): Respiratory Support and Mechanisms
2015 - Elsevier BV | Archivos de Bronconeumología

Mario Cazzola, Luigino Calzetta, Clive P. Page, José Roberto Jardim, А. Г. Чучалин, Paola Rogliani, Maria Gabriella Matera,
In order to clarify the possible role of N-acetylcysteine (NAC) in the treatment of patients with chronic bronchitis and chronic obstructive pulmonary disease (COPD), we have carried out a meta-analysis testing the available evidence that NAC treatment may be effective in preventing exacerbations of chronic bronchitis or COPD and evaluating whether there is a substantial difference between the responses induced by low (≤ 600 mg per day) and high (> 600 mg per day) doses of NAC. The results of the present ...
Tópico(s): Asthma and respiratory diseases
2015 - European Respiratory Society | European Respiratory Review

Marcela Batan Alith, Mariana Rodrigues Gazzotti, Federico Montealegre, James E. Fish, Oliver A. Nascimento, José Roberto Jardim,
To evaluate the impact of asthma on patients in Brazil, by age group (12-17 years, 18-40 years, and ≥ 41 years).From a survey conducted in Latin America in 2011, we obtained data on 400 patients diagnosed with asthma and residing in one of four Brazilian state capitals (São Paulo, Rio de Janeiro, Curitiba, and Salvador). The data had been collected using a standardized questionnaire in face-to-face interviews. For the patients who were minors, the parents/guardians had completed the questionnaire. The ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2015 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

María Montes de, María Victorina López Varela, Agustín Acuña, Eduardo Schiavi, María Alejandra Rey, José Roberto Jardim, Alejandro Casas, Antonio Tokumoto, Carlos A. Torres Duque, Alejandra Ramírez‐Venegas, Gabriel García, Roberto Stirbulov, Aquiles Assunção Camelier, Miguel Bergna, Mark E. Cohen, Santiago V. Guzmán, Efraín Sánchez,
Tópico(s): Pediatric health and respiratory diseases
2015 - Elsevier BV | Archivos de Bronconeumología

Nívia L. Nonato, Orlando Díaz, Oliver A. Nascimento, Jorge Dreyse, José Roberto Jardim, Carmen Lisboa,
Evaluar si la asociación entre el índice BODE y el deterioro de la calidad relacionada con la salud de la vida es lineal para determinar las posibles asociaciones entre el índice BODE y el estado de salud evaluadas por el Saint George's Respiratory Questionnaire (SGRQ) en todos los niveles de gravedad de la enfermedad en la EPOC. Un estudio transversal se llevó a cabo en 253 pacientes de 2 centros latinoamericanos respiratorias (Brasil y Chile) con un diagnóstico clínico de la EPOC, con base en criterios ...
Tópico(s): Respiratory Support and Mechanisms
2015 - Elsevier BV | Archivos de Bronconeumología

Laura Russo Zillmer, Mariana Rodrigues Gazzotti, Oliver A. Nascimento, Federico Montealegre, James E. Fish, José Roberto Jardim,
To evaluate the impact of asthma, by gender, in a population sample of asthma patients in Brazil.We conducted face-to-face interviews with 400 subjects (> 12 years of age) included in a national probability telephone sample of asthma patients in the Brazilian state capitals of São Paulo, Rio de Janeiro, Curitiba, and Salvador. Each of those 400 subjects completed a 53-item questionnaire that addressed five asthma domains: symptoms; impact of asthma on quality of life; perception of asthma control; ...
Tópico(s): Behavioral Health and Interventions
2014 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

Ana Maria Baptista Menezes, Rogelio Pérez‐Padilla, Fernando C. Wehrmeister, María Victorina López-Varela, Adriana Muiño, Gonzalo Valdívia, Carmen Lisboa, José Roberto Jardim, María Montes de, Carlos Tálamo, Renata Moraes Bielemann, Mariana Rodrigues Gazzotti, Ruy Laurenti, Bartolomé R. Celli, César G. Victora,
Objective To determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort. Materials/Patients and Methods Population based cohorts were followed in Montevideo, Santiago and Sao Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression ...
Tópico(s): Health disparities and outcomes
2014 - Public Library of Science | PLoS ONE

Josiane Marchioro, Mariana Rodrigues Gazzotti, Oliver A. Nascimento, Federico Montealegre, James E. Fish, José Roberto Jardim,
OBJECTIVE: To assess asthma patients in Brazil in terms of the level of asthma control, compliance with maintenance treatment, and the use of rescue medication. METHODS: We used data from a Latin American survey of a total of 400 asthma patients in four Brazilian state capitals, all of whom completed a questionnaire regarding asthma control and treatment. RESULTS: In that sample, the prevalence of asthma was 8.8%. Among the 400 patients studied, asthma was classified, in accordance with the Global ...
Tópico(s): Food Allergy and Anaphylaxis Research
2014 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

Ana Paula Luize, Ana Maria Baptista Menezes, Rogelio Pérez‐Padilla, Adriana Muiño, María Victorina López, Gonzalo Valdívia, C Lisboa, María Montes de, Carlos Tálamo, Bartolomé R. Celli, Oliver A. Nascimento, Mariana Rodrigues Gazzotti, José Roberto Jardim,
Spirometry is the gold standard for diagnosing chronic obstructive pulmonary disease (COPD). Although there are a number of different guideline criteria for deciding who should be selected for spirometric screening, to date it is not known which criteria are the best based on sensitivity and specificity. Firstly, to evaluate the proportion of subjects in the PLATINO Study that would be recommended for spirometry testing according to Global initiative for Obstructive Lung Disease (GOLD)-modified, American ...
Tópico(s): Respiratory and Cough-Related Research
2014 - Nature Portfolio | npj Primary Care Respiratory Medicine

Cristiane O. Pradella, Graziela M Belmonte, Maurício Maia, Cionéia S Delgado, Ana Paula T Luise, Oliver A. Nascimento, Mariana Rodrigues Gazzotti, José Roberto Jardim,
BACKGROUND: The aim of this study was to develop an efficient, low-cost, home-based pulmonary rehabilitation program and to evaluate the impact of the program on exercise as measured by the 6-min walk test (6MWT) and treadmill endurance test. METHODS: Twenty-nine subjects with COPD (FEV 1 = 62.4 ± 10.7% of predicted, 62.4 ± 10.7 y old) were included in a randomized and prospective pulmonary rehabilitation program, and they performed 24 sessions, 5 d/week. The control group included 15 subjects (FEV 1 = 54 ± 26.2% of predicted, ...
Tópico(s): Cardiovascular and exercise physiology
2014 - American Association for Respiratory Care | Respiratory Care

Maria Sandra Ramos Queiroz, José Roberto Jardim, María Alves Barbosa, Ruth Minamisava, Heicilainy Del Carlos Gondim, Maria Penhavel, F. Velasco, Maria Auxiliadora Carmo Moreira,
Background: Chronic obstructive pulmonary disease (COPD) is often underdiagnosed, which might be attributable to a lack of knowledge about the disease among the general population. The objective of this study was to evaluate COPD-related knowledge among primary care users in an urban area in Brazil. Methods: This study was carried out at primary care clinics (PCCs), including 12 general PCCs and 26 family health PCCs, in the city of Goiânia, Brazil. Between May 2013 and February 2014, we interviewed ...
Tópico(s): Injury Epidemiology and Prevention
2014 - Dove Medical Press | International Journal of COPD

Maria Auxiliadora Carmo Moreira, María Alves Barbosa, Maria Conceição de Castro Antonelli Monteiro de Queiroz, Kim Ir Sen Santos Teixeira, Pedro Paulo Teixeira e Silva Torres, Pedro José de Santana Júnior, Marcelo Eustáquio Montadon Júnior, José Roberto Jardim,
OBJECTIVE: To identify and characterize alterations seen on HRCT scans in nonsmoking females with COPD due to wood smoke exposure. METHODS: We evaluated 42 nonsmoking females diagnosed with wood smoke-related COPD and 31 nonsmoking controls with no history of wood smoke exposure or pulmonary disease. The participants completed a questionnaire regarding demographic data, symptoms, and environmental exposure. All of the participants underwent spirometry and HRCT of the chest. The COPD and control ...
Tópico(s): Injury Epidemiology and Prevention
2013 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

Antônio Adolfo Mattos de Castro, Elias Ferreira Pôrto, Vinícius C. Iamonti, Gérson F. de Souza, Oliver A. Nascimento, José Roberto Jardim,
To measure the oxygen and ventilatory output across all COPD stages performing 18 common ADL and identify the activities that present the highest metabolic and ventilatory output as well as to compare the energy expenditure within each disease severity.Metabolic (VO2 and VCO2), ventilatory (f and VE), cardiovascular (HR) and dyspnea (Borg score) variables were assessed in one hundred COPD patients during the completion of eighteen ADL grouped into four activities domains: rest, personal care, labor ...
Tópico(s): Nursing Diagnosis and Documentation
2013 - Public Library of Science | PLoS ONE

Christopher B. Cooper, Bartolomé R. Celli, José Roberto Jardim, Robert A. Wise, Daniel Legg, Junhai Guo, Steven Kesten,
Background Disease progression in COPD is associated with a decline in exercise performance over time. We assessed whether tiotropium might mitigate this by determining its effect on treadmill endurance time (ET) over 2 years. Methods This was a randomized, double-blind, placebo-controlled trial of tiotropium, 18 μg daily, in patients with COPD (FEV1/FVC < 70%; postbronchodilator FEV1 < 65%). The primary end point was ET at 90% of baseline maximum work rate at 96 weeks. Secondary end points were ET at ...
Tópico(s): Cardiovascular and exercise physiology
2013 - Elsevier BV | CHEST Journal

Lucas Yutaka Hayashi, Mariana Rodrigues Gazzotti, Milena Carlos Vidotto, José Roberto Jardim,
CONTEXT AND OBJECTIVE There are no reports on reintubation incidence and its causes and consequences during the postoperative period following elective intracranial surgery. The objective here was to evaluate the incidence of reintubation and its causes and complications in this situation. DESIGN AND SETTING Prospective cohort study, using data obtained at a tertiary university hospital between 2003 and 2006. METHODS 169 patients who underwent elective intracranial surgery were studied. Preoperative ...
Tópico(s): Airway Management and Intubation Techniques
2013 - Medical Association of São Paulo | Sao Paulo Medical Journal