Andrew Robson, Raymond Snoddy Media Editor, Helen Studd, Fred Redwood, Andrew Pierce, DJM, Chris Ward, Gill Trayner, James Moore, Lawrence T. Roach, Frances Gibb Legal Editor, Simon Barnes, Phll Yates, Neil Inkley, Peter Lansley, David Wilson, Mark Souster, Saad Hattar, Catherine Phlip, Richard Hobson, Jenny Davis, Ivo Tennant, Michael Evans Defence Editor, Philip Howard, Ian Cobain, Philip Webster, Roland Watson and Greg Hurst, David Chater, James Bone, Rachel Campbell-Johnston, Penny Wark, Alexandra Frean Social Affairs Correspondent, Arthur Levitt, Gabrielle Starkey, Lynne Truss, Michael Humphreys, Carl Mortished, Alastair Caldwell, Gillian Harris Scotland Correspondent, Jeremy Whittle, Raymond Snoddy, Sam Lister, Joe Joseph, David Sharrock, David McVay, Anne Spackman Property Editor, Michael Evans and Richard Beeston, Donald Hutera, Jennai Cox Fitness Editor, Dominic Walsh, James Doran Wall Street Correspondent, Debra Craine, Rachel Holmes, Gary Jacob, Tony Plews, Ross Dunn, Dalya Alberge Arts Correspondent, Oliver Wright, Roland Watson, Martin Foster, Matt Dickinson Chief Football Correspondent, Anthea Lawson, Mark Court, Lisa Jardine, Russell Kempson, David Rowan, Tony Halpin Education Editor, Richard Cork, Oliver Kay, Fiona McNeill, Tom Baldwin, Mark Henderson Science Correspondent, Sam Coates, Dell Williams, Paul Sexton, Karen Homer, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Peter Chapman, Headmaster, David Powell Athletics Correspondent, Martin Samuel, Raymond Keene, Michael Evans, Michael Dynes, Catherine Philp, Richard Beeston and Alice Lagnado, Adam Sage, John Russell Taylor, Cheryl Taylor, B. Sheerman, Chris Partridge, Greg Hurst Parliamentary Correspondent, Andy Smith, Chris Campling, Bronwen Maddox, Russell Hotten, Richard Owen, Helen Nugent, Christopher Martin-Jenkins Chief Cricket Correspondent, Roger Boyes, Nick Hasell, Nick Kelly, Dalya Alberge, Walter Williamson, Nick Szczepanik, John Goodbody, Joanna Pitman, Neil King, Mary Ann Sieghart, Melissa Kite Political Correspondent, Benedict Rogers, C. Hopkins, Mel Webb, Matthew Parris, Chris McGrath, Peter Chesson, George Caulkin, John Hopewell, Peter Riddell, Ben MacIntyre, Lea Paterson Economics Editor, Jeremy Hart, Richard Beeston Diplomatic Editor, Ian Whittell, Jack Malvern Arts Reporter, Simon Jenkins, Anne Ashworth Personal Finance Editor, Catherine Philp, Martin Waller, Michael Horsnell, Alan Coren, Peter Gardner, Nigel Hawkes Health Editor, Laura Peek, Charles Duelfer, Ashling O'Connor, Edward Raikes, Stephen Dalton, Richard Morrison, Bill Edgar, Alice Miles, John Appleyard, Abigail Rayner, Michael Evans, Sally Patten, Nicholas Jose, Sally Patten Retail Correspondent, Patience Wheatcroft, Janine di Giovanni, Christopher Irvine, David Lister Ireland Correspondent,
... new book, part travelogue, part personal quest, Nicholas Jose follows Australia's McArthur River to Borroloola in search of his relative Roger Jose - a fugitive from modernity The 3,000 books ...
2002 - Gale Group | TDA
José R. Saad, Jose G. Davicino, Óscar S. Giordano,
From the aerial parts of Baccharis flabellata, two new clerodane type diterpenes were isolated together with oleanolic acid and four known flavonoids. The structures of the new compounds were elucidated by spectroscopic methods.
Tópico(s): Natural product bioactivities and synthesis
1988 - Elsevier BV | Phytochemistry
From Roger Berthoud, From Robert Fisk Belfast, By Peter Jay Econimics Editor, From Fred Emery, By Peter Scott, By Geraldine Norman Sale Room Correspondent, By George Clark Political Correspondent, From a Staff Reporter Belfast, By Our Education Correspondent, By Pat healy Social Services Correspondent, By Diana Geddes, By John Groser Political Staff, From Our Correspondent Shrewsbury, By Paul Routledge Labour Editor, By Raymond Perman Labour Staff, By John Roper Medical Reporter, By Our Air Correspondent, By a Staff Reporter, Hugh Clayton, By Alan Hamilton Labour Staff, By Hugh Clayton, By Our Medical Reporter, By Our Political Staff, By Kenneth Gosling, From Our Correspondent Worcester, By Our Estates Correspondent, By Our Social Services Correspondent, From Jose Shercliff, From Richard Wigg, From Dan van der Vat, From Charles Hargrove, From David Cross, By Marcel Berlins Our Legal Correspondent, From Frank Vogl, From Moshe Brilliant, From Paul Martin, From Our Own Correspondent, From Peter Hazelhurst, From Our Correspondent, From Peter Strafford, From David Bonavia, By Henry Stanhope Defence Correspondent, From Michael Knipe, David Robinson, William Mann, John Percival, Stanley Reynolds, Thomas Walker, Stanley Sadie, Stephen Walsh, By Peter West Rugby Correspondent, From Dennis Bird, By Rex Bellamy Squash Rackets Correspondent, From a Special Correspondent, By Joyce Whitehead, From John Woodcock Cricket Correspondent, By Neil Allen Athletics Correspondent, By Neil Allen, Dr Tony Smith medical Correspondent, Dr Colin Brewer, Michael Harry, Hugh Fraser, PHS, Roger Berthoud, R. EL-TAI, , P. H. HUTTON, , I. O. CHANCE, , JEREMY BENSON, , JOHN CORNFORTH, , JENNIFER JENKINS, , G. F. SMITH, , JEFFREY WILLIAMS, , JULIAN RIDSDALE, , J. R. L. CUNINGHAM, , SAAD EL SHAZLY, , JAMES LEES-MILNE, , GEOFFREY GRIGSON, , IVOR GUEST, , J. F. C. KINGMAN, , ORR-EWING, , By Our Arts Reporter, Q. B. writes:, By Terry Byland, By John Plender, By Our Industrial Editor, By Geoffrey Browning parliamentary Staff, By Patricia Tisdall, By Margaret Stone, By Clifford Webb, By Peter Hill, By Maurice Corina Industrial Editor, By Edward Townsend, From John Earle, By R. W. Shakespeare Northern Industrial Correspondent, By Our Labour Staff, By Tim Congdon, TIM LAMPORT, , ELLES BICKNELL, , CHRISTIAN BRANN, , C. B. P. BIRCH, , BY THE FINANCIAL EDITOR, Kenneth Owen, By Ashley Druker, Gerald Ely,
News: Hongkong ex-police chief for trial next month, Moscow rejects blame for falling Jewish emigration, Transplants 'should be allowed while heart still ...
1975 - Gale Group | TDA
Produção Nacional
Revisado por pares
Carlos Vinícius Buarque de Gusmão, José Rodrigo Pauli, Mário J.A. Saad, José Marcos Alves, William Dias Belangero,
Low-intensity pulsed ultrasound stimulation (LIPUS) reportedly increases osteogenesis in fracture models but fails in intact bone, suggesting LIPUS does not act on mechanotransduction and growth factor pathways of intact bone.We asked whether daily 20-minute LIPUS applied to intact tibias would act on bone proteins involved in mechanotransduction (focal adhesion kinase [FAK], and extracellular signal-regulated kinase-1/2 [ERK-1/2]), and growth factor signaling (insulin receptor substrate-1 [IRS-1]) pathways ...
Tópico(s): Tendon Structure and Treatment
2009 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Muthiah Vaduganathan, Robert A. Harrington, Gregg W. Stone, Efthymios Deliargyris, Philippe Gabríel Steg, C. Michael Gibson, Christian W. Hamm, Matthew J. Price, Alberto Menozzi, Jayne Prats, Steven Elkin, Kenneth W. Mahaffey, Harvey D. White, Deepak L. Bhatt, Fernando Cura, M Ballarino, Aníbal Damonte, Diego Grinfeld, Carlos Alejandro Álvarez, Alberto Ocaña, A. Farshid, Brendan Gunalingam, Craig Jeurgens, Harry C. Lowe, H. Hallani, G. Nelson, Gishel New, Ronald Dick, Jeffrey Lefkovits, Stephen W. Duffy, Nick Bett, Raibhan Yadav, P. Garrahy, Ron Lehman, Philip E. Aylward, John D. Horowitz, M. Worthley, D. Cross, Jaime Rankin, Peter Thompson, Phil Roberts-Thomson, D. Cross, Rohan Jayasinghe, Con Aroney, Kurt Huber, F Leisch, Johann Altenberger, Georg Gaul, Thomas Neunteufl, Franz Weidinger, Herwig Schuchlenz, H. Wéber, Werner Benzer, Paulo Roberto Ferreira ROSSI, Breno Oliveira Almeida, Antônio Francisco Godinho, Fábio Vilas‐Boas, Luciano Janussi Vacanti, Renato Giestas Serpa, José Antonio Jatene, Gilmar Reis, Jamil Abdalla Saad, Marcos Maynar-Mariño, Roberto Botelho, Constantino Costantini, Ricardo Wang, Dalton Bertolim Précoma, M Rati, L. C. Bodanese, Euler Roberto Fernandes Manenti, João Paulo Zouvi, Rogério Tumelero, Arthur Herdy, Eulógio Martinez Filho, Antônio Carlos Carvalho, Roberto Alexandre Franken, Lawrence Title, Charles Lazzam, François Reeves, Tamaz Shaburishvili, Gulnara Chapidze, Merab Mamatsashvili, Irakli Khintibidze, Kurt Huber, Hans‐Georg Olbrich, Sabine Genth‐Zotz, S Moebius-Winkler, Michael Buerke, Stefan Hoffmann, Peter W. Radke, Helge Moellmann, Hugo A. Katus, HANS-FRIEDRICH VOEHRINGER, Christian Hengstenberg, Volker Klauß, Johannes Brachmann, Aftab Ahmad Khan, Sampath Kumar, P.P. Mohanan, Praveen Chandra, M. Bhaskar Rao, S. S. Ramesh, Keyur Parikh, Arun Srinivas, Nakul Sinha, G. K. Surya Prakash, Shirish Hiremath, Anil Mishra, Sanjeeb Roy, Kamal Sethi, Ashwani Mehta, Tejas Patel, Suman Bhandari, Milind Gadkari, Milind Gadkari, Stefano De Servi, Giuseppe Musumeci, Alberto Menozzi, Bernardo Cortese, Giancarlo Marenzi, Raffaele De Caterina, Ralph Stewart, Gerard Devlin, Scott A. Harding, John F. Elliott, Gerard T. Wilkins, D. Scott, Sławomir Dobrzycki, Waldemar Dorniak, Dariusz Dudek, Zbigniew Gąsior, Jarosław Hiczkiewicz, Zdzisława Kornacewicz‐Jach, Leszek Kubik, Krzysztof Kuc, Jerzy Kuźniar, Walentyna Mazurek, Jakub Ostrowski, Michał Tendera, Andrzej Wiśniewski, Elżbieta Zinka, Krzysztof Żmudka, Jana Pawła, Maciej Kośmider, Seweryna, Andrés Íñiguez, Rafael Melgares, Francisco Javier Goicolea, José Hernández, Javier Zueco, Igor Kraiz, Mykola Vatutin, Anatoliy Polyakov, Y.N. Sokolov, Kenneth W. House, Charles Campbell, Timothy Trageser, Kenneth W. Baran, Neal S. Kleiman, Roberto Medina, Roger Hill, M. Zubair Jafar, David Drenning, Herbert Ladley, Adil Al‐Nahhas, Alan Niederman, Amit Goyal, William B. Abernethy, Naseem Jaffrani, Richard Zelman, B J Negus, José Marquez, Ehtisham Mahmud, William J. French, John Paulowski, Charles V. Pollack, M Mines, Robert Federici, Marc J. Schweiger, Kalim Habet, Ofsman Quintana, Thomas W. Nygaard, Steve Orlow, Douglas Spriggs, Ivan Chavez, M. Warner, Richard Paulus, David Cochran, Cary Hirsch, Ajay Virmani, Peter Soukas, Nalin Srivastava, Laurent Ferrier, Annapoorna Kini, Mark A. Greenberg, Hartmut Herrmann, Valerian Fernandes, Barry Bertolet, Ron Waksman, Joseph B. Henderson, Harinder Gogia, Maged Amine, Kourosh Mastali, Thomas Stuckey, Peter Hui, Luigi Pacifico, Todd Caulfield, Wilson Ginete, William L. Ballard, Robert Iwaoka, Joseph Stella, Vijay K. Misra, Costa Andreou, Michele Voeltz, Wayne Batchelor, Cezar Staniloae, Sanford J. Gips, Jeffrey Kramer, Paul Mahoney, John Wang, Prospero Gogo, David G. Rizik, David G. Rizik, Rex J. Winters, G. Hunter Mackenzie, Stephen J. Jenkins, Paul Teirstein, Pierre P. Leimgruber, J. Christopher Scott, Seth Krauss, Steven Rohrbeck, Robert G. Martin, Gustavo Grieco, Louis Cannon, Don Westerhausen, F. David Fortuin, Steven P. Schulman, Joel Cohn, Brent McLaurin, Jorge Saucedo, Robert Wozniak, J. J. Hall, Kevin Marzo, Merrill Krolick, Lawrence W. Gimple, Eric Hockstad, Arsenio Rodriguez, John Kao, Adhir Shroff, Michael Attubato, Ramon Quesada, Ernesto Rivera, Larry S. Dean, Russell Raymond, Thomas M. Amidon, David Lee, Spencer King, John S. Douglas, Abnash C. Jain, J Patrick Kleaveland, Mitchell Driesman, Krishna Kumar, Glen J. Kowalchuk, Behzad Taghizadeh, Lawrence A. Barr, Keith Benzuly, Tarek Helmy, Duane S. Pinto, Joseph Aragon, Reginald Low, Phillip A. Horwitz, Thomas D. LeGalley, Dominick J. Angiolillo, Rajesh Sachdeva, Kenneth M. Kent, Luis Gruberg, Richard G. Bach, Thomas Pow, Charles O’Shaughnessy, Shing Chiu Wong, Saeed R. Shaikh, Arthur Reitman, Mark E. Lawrence, Fernando Cura, Alejandro García Escudero, Carlos Poy, Miguel Miceli, Antonio Pocoví, Hugo Londero, Jorge Baccaro, L. Z. Polonetsky, Aliaksey Karotkin, Leanid Shubau, Eduardo da Rosa Maffini, Bruno Martins Machado, José Airton,
Cangrelor, an intravenous, reversible P2Y12 antagonist, is approved for use in patients undergoing percutaneous coronary intervention (PCI). This study sought to evaluate the efficacy and safety of cangrelor compared with clopidogrel in subgroups that did and did not receive glycoprotein IIb/IIIa inhibitors (GPIs). This pooled, patient-level analysis of the 3 CHAMPION (Cangrelor versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition) trials analyzed all randomized patients who ...
Elsevier BV
Produção Nacional
Revisado por pares
João Batista Michelotto, José Barreto Campello Carvalheira, Mário J.A. Saad, José Antônio Rocha Gontijo,
The role of the central nervous system (CNS) in the control of hydrosaline homeostasis has been strikingly demonstrated by several studies. Growing evidence suggests that insulin may exert an influence in the modulation of many brain functions. However, there are no available data examining the CNS effect of insulin injection on renal sodium handling. Also, to examine the influence of renal nerve activity during i.c.v. administration of insulin, unanesthetized, unrestrained rats were randomly assigned ...
Tópico(s): Ion Transport and Channel Regulation
2002 - Elsevier BV | Brain Research Bulletin
Produção Nacional
Revisado por pares
Marcia Aparecida Thomaz, Simone Coghetto Acedo, Caroline Candida de Oliveira, José Aires Pereira, Denise Gonçalves Priolli, Mário J.A. Saad, José Pedrazzoli, Alessandra Gambero,
Mesenteric white adipose tissue hypertrophy and modifications in adipocytokine production are described features of Crohn's disease. Experimentally, mesenteric white adipose tissue alterations, associated with intestinal inflammation, can be induced in a model of reactivated colitis by repeated administration of intrarectal trinitrobenzenosulfonic acid (TNBS) in ethanol solution. Crohn's disease patients refractory to corticosteroid treatment are frequently treated with methotrexate; however, there ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2009 - Elsevier BV | Pharmacological Research
Produção Nacional
Revisado por pares
Leda Márcia Araújo Bento, José Barreto Campello Carvalheira, Leonardo Fantinato Menegon, Mário J. A. Saad, José Antônio Rocha Gontijo,
Background. There is a surprising lack of experimental data on the mechanisms of NH4Cl-induced chronic metabolic acidosis which causes kidney hypertrophy. The NH4Cl treatment results in an absolute increase in kidney mass. Despite findings to indicate a close interaction between NH4Cl-induced chronic metabolic acidosis and renal enlargement, the role of the stimulated serine kinase cascade, mediated by the stepwise activation of extracellular signal-regulated kinase (ERK) signalling, on kidney hypertrophy ...
Tópico(s): Nitric Oxide and Endothelin Effects
2005 - Oxford University Press | Nephrology Dialysis Transplantation
Produção Nacional
Revisado por pares
Márcio Alberto Torsoni, José Barreto Campello Carvalheira, VC Calegari, Rosângela Maria Neves Bezerra, MJ Saad, José Antônio Rocha Gontijo, LA Velloso,
Angiotensin II exerts a potent dypsogenic stimulus on the hypothalamus, which contributes to its centrally mediated participation in the control of water balance and blood pressure. Repetitive intracerebroventricular (i.c.v.) injections of angiotensin II lead to a loss of effect characterized as physiological desensitization to the peptide's action. In the present study, we demonstrate that angiotensin II induces the expression of suppressor of cytokine signaling (SOCS)-3 via angiotensin receptor ...
Tópico(s): Hormonal Regulation and Hypertension
2004 - Bioscientifica | Journal of Endocrinology
Produção Nacional
Revisado por pares
Eduardo R. Ropelle, José Rodrigo Pauli, Maria F. Fernandes, Silvana A. Rocco, Rodrigo Marín-Navarrete, Joseane Morari, Kellen K. Souza, Marília M. Dias, Maria Cristina Cintra Gomes‐Marcondes, José Antônio Rocha Gontijo, Kleber G. Franchini, Lı́cio A. Velloso, Mário J.A. Saad, José Barreto Campello Carvalheira,
OBJECTIVE—A high-protein diet (HPD) is known to promote the reduction of body fat, but the mechanisms underlying this change are unclear. AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) function as majors regulators of cellular metabolism that respond to changes in energy status, and recent data demonstrated that they also play a critical role in systemic energy balance. Here, we sought to determine whether the response of the AMPK and mTOR pathways could contribute to ...
Tópico(s): Regulation of Appetite and Obesity
2007 - American Diabetes Association | Diabetes
Produção Nacional
Revisado por pares
Eduardo R. Ropelle, José Rodrigo Pauli, Karina G. Zecchin, Mirian Ueno, Cláudio Teodoro de Souza, Joseane Morari, Marcel C. Faria, Lı́cio A. Velloso, Mário J.A. Saad, José Barreto Campello Carvalheira,
The pathogenesis of cancer anorexia is multifactorial and associated with disturbances of the central physiological mechanisms controlling food intake. However, the neurochemical mechanisms responsible for cancer-induced anorexia are unclear. Here we show that chronic infusion of 5-amino-4imidazolecarboxamide-riboside into the third cerebral ventricle and a chronic peripheral injection of 2 deoxy-d-glucose promotes hypothalamic AMP-activated protein kinase (AMPK) activation, increases food intake, ...
Tópico(s): Regulation of Appetite and Obesity
2007 - Oxford University Press | Endocrinology
Produção Nacional
Revisado por pares
Eduardo R. Ropelle, José Rodrigo Pauli, Patrícia O. Prada, Cláudio Teodoro de Souza, Paty K. Picardi, Marcel C. Faria, Dennys E. Cintra, Maria Fernanda de Andrade Fernandes, Marcelo B.S. Flores, Lı́cio A. Velloso, Mário J.A. Saad, José Barreto Campello Carvalheira,
Lifestyle interventions including exercise programmes are cornerstones in the prevention of obesity-related diabetes. In this study, we demonstrate that a single bout of exercise inhibits high-fat diet-induced insulin resistance. Diet-induced obesity (DIO) increased the expression and activity of the protein tyrosine phosphatase 1B (PTP1B) and attenuated insulin signalling in gastrocnemius muscle of rats, a phenomenon which was reversed by a single session of exercise. In addition, DIO was observed ...
Tópico(s): Metabolism, Diabetes, and Cancer
2006 - Wiley | The Journal of Physiology
Produção Nacional
Revisado por pares
Eduardo R. Ropelle, Marcelo B.S. Flores, Dennys E. Cintra, Guilherme Z. Rocha, José Rodrigo Pauli, Joseane Morari, Cláudio Teodoro de Souza, Juliana C. Moraes, Patrícia O. Prada, Dioze Guadagnini, Rodrigo Marín-Navarrete, Alexandre G. Oliveira, Taize Machado Augusto, Hernandes F. Carvalho, Lı́cio A. Velloso, Mário J.A. Saad, José Barreto Campello Carvalheira,
Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKbeta activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKbeta/NF-kappaB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (IL)-6. The disruption of hypothalamic-specific IL-6 action blocked the beneficial effects of exercise on the re-balance of food intake and insulin ...
Tópico(s): Exercise and Physiological Responses
2010 - Public Library of Science | PLoS Biology
Produção Nacional
Revisado por pares
Eduardo R. Ropelle, José Rodrigo Pauli, Dennys E. Cintra, Adelino Sánchez Ramos da Silva, Cláudio Teodoro de Souza, Dioze Guadagnini, Bruno M. Carvalho, Andréa M. Caricilli, Carlos K. Katashima, Carvalho Filho, Sandro Massao Hirabara, Rui Curi, Lı́cio A. Velloso, Mário J.A. Saad, José Barreto Campello Carvalheira,
Accumulating evidence has demonstrated that S-nitrosation of proteins plays a critical role in several human diseases. Here, we explored the role of inducible nitric oxide synthase (iNOS) in the S-nitrosation of proteins involved in the early steps of the insulin-signaling pathway and insulin resistance in the skeletal muscle of aged mice. Aging increased iNOS expression and S-nitrosation of major proteins involved in insulin signaling, thereby reducing insulin sensitivity in skeletal muscle. Conversely, ...
Tópico(s): Adipose Tissue and Metabolism
2012 - American Diabetes Association | Diabetes
Margaux F. Keller, Mohamad Saad, José Brás, Francesco Bettella, Nayia Nicolaou, Javier Simón‐Sánchez, Florian Mittag, Finja Büchel, Manu Sharma, J. Raphael Gibbs, Joshua Shulman, Valentina Moskvina, Alexandra Dürr, Peter Holmans, Laura L. Kilarski, Rita Guerreiro, D. G. Hernandez, Alexis Brice, Pauli Ylikotila, Hreinn Stefánsson, Kari Majamaa, Huw R. Morris, N. Williams, Thomas Gasser, Peter Heutink, Nicholas Wood, John Hardy, María Martínez, Andrew Singleton, Mike A. Nalls,
Tópico(s): Neurological diseases and metabolism
2013 - Oxford University Press | Human Molecular Genetics
Produção Nacional
Revisado por pares
Wilson A. Saad, José Antunes‐Rodrigues, C Gentil, Miguel R. Covian,
The studies were made in rats employing the standard two-bottle self-selection procedure. Rats with increased salt intake due to lesions in the amygdaloid complex or in septal area diminished their intake following hypothalamic lesions which in the intact rat causes decreases. When the hypothalamic lesions were made first, amygdaloid or septal lesions did not induce any change. Rats with decreased salt intake because of amygdaloid lesions showed an augmented ingestion after septal lesions but if ...
Tópico(s): Regulation of Appetite and Obesity
1972 - Elsevier BV | Physiology & Behavior
Produção Nacional
Revisado por pares
Alice Xavier Pillar, C. R. Silva-Netto, L.A.A. Camargo, Wilson A. Saad, José Antunes‐Rodrigues, Miguel R. Covian,
The effects of adrenergic stimulation of the lateral hypothalamic area on sodium and potassium excretion were studied in rats bearing implanted cannulae. When noradrenaline was injected into several points of the lateral hypothalamic area, a dose-related increase in natriuresis and kaliuresis was observed. Rats previously injected through the same cannulae with alpha (Regitine) or beta (Propranolol) blocking agents showed different natriuretic responses when injected with noradrenaline. It was observed ...
Tópico(s): Stress Responses and Cortisol
1977 - Elsevier BV | Pharmacology Biochemistry and Behavior
Produção Nacional
Revisado por pares
Musculature of 36 specimens of Pagrus pagrus from the coastal zone of the State of Rio de Janeiro were examined to study larval of anisakid nematodes between January and May 2008.A total of 24 larval of Anisakis sp., Contracaecum sp., Hysterothylacium sp. and Raphidascaris sp. were collected infecting seven fishes (19.4%).Larval Hysterothylacium sp. and Contracaecum sp.showed highest prevalence and Hysterothylacium sp.highest parasite abundance.This is the first record of larval anisakids in the ...
Tópico(s): Fish Biology and Ecology Studies
2009 - Colégio Brasileiro de Parasitologia Veterinaria | Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology
Alejandro Perez‐Lugones, James T. McMahon, Norman B. Ratliff, Walid I. Saliba, Robert A. Schweikert, Nassir F. Marrouche, Eduardo Saad, José Navia, Patrick M. McCarthy, Patrick Tchou, A. Marc Gillinov, Andrea Natale,
Specialized Conducting Cells in Human PV.Depolarizations similar to those from the sinus node have been documented from the pulmonary veins after isolation procedures. We assessed the hypothesis that sinus node-like tissue is present in the pulmonary veins of humans.Pulmonary vein tissue was obtained from five autopsies (four individuals with a history of atrial fibrillation and one without a history of atrial arrhythmias) and five transplant heart donors. Autopsy veins were fixed in formaldehyde ...
Tópico(s): Hydrogen embrittlement and corrosion behaviors in metals
2003 - Wiley | Journal of Cardiovascular Electrophysiology
Produção Nacional
Revisado por pares
Rosemary Bastos, Wilson A. Saad, José Vanderlei Menani, Antonio Renzi, JoséEduardo Nogueira Silveira, Luiz Antônio de Arruda Camargo,
In this study, we investigated the participation of adrenergic neurotransmission in angiotensin II- (ANGII)-induced water intake and urinary electrolyte excretion by means of injection of the α1-, α2-, and β-adrenoceptor antagonists and ANGII into the medial preoptic area (MPOA) in rats. Prazosin (an α1-adrenergic antagonist) entagonized the water ingestion, Na+, K+ and urine excretion induced by ANGII, whereas yohimbine (an α2-adrenergic antagonist) enhanced the Na+, K+ and urine excretion induced ...
Tópico(s): Hormonal Regulation and Hypertension
1994 - Elsevier BV | Brain Research
Produção Nacional
Revisado por pares
Eduardo R. Ropelle, Maria F. Fernandes, Marcelo B.S. Flores, Mirian Ueno, Silvana A. Rocco, Rodrigo Marín-Navarrete, Dennys E. Cintra, Lı́cio A. Velloso, Kleber G. Franchini, Mário J.A. Saad, José Barreto Campello Carvalheira,
AMP-activated protein kinase (AMPK) and mammalian Target of Rapamycin (mTOR) are key regulators of cellular energy balance and of the effects of leptin on food intake. Acute exercise is associated with increased sensitivity to the effects of leptin on food intake in an IL-6-dependent manner. To determine whether exercise ameliorates the AMPK and mTOR response to leptin in the hypothalamus in an IL-6-dependent manner, rats performed two 3-h exercise bouts, separated by one 45-min rest period. Intracerebroventricular ...
Tópico(s): Adipose Tissue and Metabolism
2008 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Josenilson Campos de Oliveira, Kellen K. Souza, Marília M. Dias, Marcel C. Faria, Eduardo R. Ropelle, Marcelo B.S. Flores, Mirian Ueno, Lı́cio A. Velloso, Sara Teresinha Olalla Saad, Mário J.A. Saad, José Barreto Campello Carvalheira,
Tópico(s): Metabolism, Diabetes, and Cancer
2008 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Produção Nacional
Revisado por pares
Livia de Fraia Pinto, Cecília Melleti Compri, João Victor Fornari, Waldemar Bartchewsky, Dennys E. Cintra, Miriam Trevisan, Patrícia de Oliveira Carvalho, Marcelo Lima Ribeiro, Lı́cio A. Velloso, Mário J.A. Saad, José Pedrazzoli, Alessandra Gambero,
Pro-inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, are known to be involved in the establishment of insulin resistance. Insulin resistance plays a key role in the development of obesity-related pathologies, such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The state of chronic inflammation associated with obesity led us to hypothesize that TNF-alpha blockade may have an effect on experimentally obese animals.We studied the effects of thalidomide, an immunosuppressant ...
Tópico(s): Lipid metabolism and disorders
2010 - Wiley | Liver International
Produção Nacional
Revisado por pares
Alessandra Gambero, Marta Maróstica, Mário J.A. Saad, José Pedrazzoli,
Adipose tissue secretes a large number of hormones that act either locally or at distant sites, modulating immune responses, inflammation, and many endocrine and metabolic functions. Abnormalities of fat in the mesentery have been long recognized in surgical specimens as characteristic features of Crohn's disease; however, the importance of this in chronic inflammatory disease is unknown. Additionally, adipocytes in depots that enclose lymph nodes or other dense masses of lymphoid tissue have many ...
Tópico(s): Pancreatitis Pathology and Treatment
2007 - Oxford University Press | Inflammatory Bowel Diseases
Produção Nacional
Revisado por pares
Guilherme Z. Rocha, Marília M. Dias, Eduardo R. Ropelle, Felipe Osório–Costa, Franco A. Rossato, Anı́bal E. Vercesi, Mário J.A. Saad, José Barreto Campello Carvalheira,
Metformin is a widely used antidiabetic drug whose anticancer effects, mediated by the activation of AMP-activated protein kinase (AMPK) and reduction of mTOR signaling, have become noteworthy. Chemotherapy produces genotoxic stress and induces p53 activity, which can cross-talk with AMPK/mTOR pathway. Herein, we investigate whether the combination of metformin and paclitaxel has an effect in cancer cell lines.Human tumors were xenografted into severe combined immunodeficient (SCID) mice and the cancer ...
Tópico(s): Cancer-related Molecular Pathways
2011 - American Association for Cancer Research | Clinical Cancer Research
Produção Nacional
Revisado por pares
Paulo Herman, Marcos V. Perini, Marcel Autran C. Machado, Telésforo Bacchella, Vincenzo Pugliese, William Abrão Saad, José Eduardo Monteiro da Cunha, Marcel Cerqueira César Machado, Joaquim Gama Rodrigues,
The current study sought to evaluate the results of liver resection as the treatment for unilateral non-oriental primary intrahepatic lithiasis (PHIL).Twenty-seven symptomatic patients (mean age 42 years) were submitted to liver resection; the indications were parenchymal fibrosis/atrophy in 22 and biliary stenosis in 5. Resection was associated with a Roux-en-Y hepaticojejunostomy in patients with a significant degree of dilation of the extrahepatic biliary duct.There was no operative mortality and ...
Tópico(s): Biliary and Gastrointestinal Fistulas
2006 - Elsevier BV | The American Journal of Surgery
Produção Nacional
Revisado por pares
Marcelo B.S. Flores, Maria F. Fernandes, Eduardo R. Ropelle, Marcel C. Faria, Mirian Ueno, Lı́cio A. Velloso, Mário J.A. Saad, José Barreto Campello Carvalheira,
Prolonged exercise of medium to high intensity is known to promote a substantial effect on the energy balance of rats. In male rats, moderately to severely intense programs lead to a reduction in food intake. However, the exact causes for the appetite-suppressive effects of exercise are not known. Here, we show that intracerebroventricular insulin or leptin infusion reduced food intake in exercised rats to a greater extent than that observed in control animals. Exercise was associated with a markedly ...
Tópico(s): Adipose Tissue and Metabolism
2006 - American Diabetes Association | Diabetes
Margaux F. Keller, Mohamad Saad, José Brás, Francesco Bettella, Nayia Nicolaou, Javier Simón‐Sánchez, Florian Mittag, Finja Büchel, Manu Sharma, J. Raphael Gibbs, Joshua Shulman, Valentina Moskvina, Alexandra Dürr, Peter Holmans, Laura L. Kilarski, Rita Guerreiro, D. G. Hernandez, Alexis Brice, Pauli Ylikotila, Hreinn Stefánsson, Kari Majamaa, Huw R. Morris, N. Williams, Thomas Gasser, Peter Heutink, Nicholas Wood, John Hardy, María Martínez, Andrew Singleton, Michael A. Nalls,
Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with common traits remains unaccounted for within the genome. Genome-wide complex trait analysis (GCTA) is a statistical method that applies a linear mixed model to estimate phenotypic variance of complex traits explained by genome-wide SNPs, including those not associated with the trait in ...
Tópico(s): Genetic Associations and Epidemiology
2012 - Oxford University Press | Human Molecular Genetics
Produção Nacional
Revisado por pares
Marcelo B.S. Flores, Guilherme Z. Rocha, Danilo Marchete Damas-Souza, Felipe Osório–Costa, Marília M. Dias, Eduardo R. Ropelle, Juliana Alves de Camargo, Rita Barbosa de Carvalho, Hernandes F. Carvalho, Mário J.A. Saad, José Barreto Campello Carvalheira,
BACKGROUND & AIMS:Epidemiology studies have shown that obesity increases risk for colorectal cancer (CRC).We investigated the contribution of obesity-induced increases in levels of tumor necrosis factor (TNF)-␣ and hyperinsulinemia to the development of CRC in mice.METHODS: Lean and obese mice (C57BL6/J and ob/ob) were given a combination of azoxymethane and dextran sulfate sodium, which led to the development of CRC; lean and obese severe combined immunodeficient mice were injected with HT-29 cells. ...
Tópico(s): Cancer-related Molecular Pathways
2012 - Elsevier BV | Gastroenterology
Produção Nacional
Revisado por pares
Raphael R. Prattali, Guilherme Barreiro, Caio T. Caliseo, Felipe Y. Fugiwara, Mirian Ueno, Patrícia O. Prada, Lı́cio A. Velloso, Mário J.A. Saad, José Barreto Campello Carvalheira,
In this study, we demonstrate that pretreatment with aspirin inhibits GH‐induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS‐1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRS/PI(3)kinase pathway and a reduction in IRS‐1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2005 - Wiley | FEBS Letters