Jessica M. Sanfilippo, José F. Muñoz, M. Isabel Tejedor, Marc A. Anderson, Steven M. Cramer,
It is well recognized that the area of contact between cement paste and aggregates, known as the interfacial transition zone (ITZ), is one of the most vulnerable areas of concrete. The microstructure, chemistry, porosity, and mineralogy of this interface affect the adhesion between the aggregate and the cement paste and therefore, under certain conditions, dictate the performance of concrete. The traditional strategy for improving the ITZ has been the addition of pozzolanic materials having a close ...
Tópico(s): Recycled Aggregate Concrete Performance
2010 - SAGE Publishing | Transportation Research Record Journal of the Transportation Research Board
Antoine Vieillard‐Baron, Scott J. Millington, Filippo Sanfilippo, Michelle S. Chew, José L. Díaz‐Gómez, Anthony S. McLean, Michael R. Pinsky, Juan N. Pulido, Paul H. Mayo, Nick Fletcher,
This narrative review focusing on critical care echocardiography (CCE) has been written by a group of experts in the field, with the aim of outlining the state of the art in CCE in the 10 years after its official recognition and definition. In the last 10 years, CCE has become an essential branch of critical care ultrasonography and has gained general acceptance. Its use, both as a diagnostic tool and for hemodynamic monitoring, has increased markedly, influencing contemporary cardiorespiratory management. ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2019 - Springer Science+Business Media | Intensive Care Medicine
Andrés Aranda, Carlos Viesca, Gabino Sánchez, Gabriel Sanchez-Perez, Mariblanca Ramos de Viesca, José Sanfilippo,
LA REVISION SOBRE LA MATERIA MEDICA DEL LIBELLUS DE MEDICINALIBUS INDORUM HERBIS ESCRITO EN NAHUA POR EL MEDICO INDIGENA MEXICANO MARTIN DE LA CRUZ Y TRADUCIDO AL LATIN POR OTRO INDIO MEXICANO JUAN BADIANO, FORMADO EN EL COLEGIO DE LA SANTA CRUZ DE TLATELOLCO, CON PRECIOSOS DIBUJOS DE LOS TLACUILOS INDIGENAS, PERMITE ESTABLECER Y AFIRMAR ALGUNAS CONSIDERACIONES. 1. SI BIEN EN EL MANUSCRITO EXISTE LA PRESENCIA DE ELEMENTOS DE EXTRACCION EUROPEA, LA MAYORIA DE ELLOS ESTABAN PRESENTES Y ERAN UTILIZADOS ...
Tópico(s): Botanical Research and Chemistry
2003 - National University of Colombia | Revista de la Facultad de Medicina
Federica Grosso, Palma Dileo, Roberta Sanfilippo, Silvia Stacchiotti, Rossella Bertulli, C. Piovesan, José Jimeno, Maurizio D’Incalci, Andreas J. Gescher, Paolo G. Casali,
Trabectedin is a marine-derived cytoxic alkaloid which has shown promising antitumour activity in a variety of human malignancies including sarcoma. Fifty-four patients with advanced sarcoma (age 43 yrs, range 18–70), all pretreated with prior chemotherapy, were enrolled on a named individual basis for treatment with trabectedin. Diagnosis was adult soft tissue sarcoma (STS) in 46 patients, Ewing's family tumour (EFT) in 4, and osteosarcoma (OS) in 4. The initial 23 patients (total number of courses ...
Tópico(s): Cancer Research and Treatments
2006 - Elsevier BV | European Journal of Cancer
Since the War on Terror began, female troops have increasingly participated in combat operations. Even as the wars have created the first known cluster of female combat amputees, their stories are rarely represented or studied. This neglect has resulted in physical and mental health consequences. This article addresses this omission through an analysis of literary representations of injured female troops by Gologorsky, Proulx, and Schultz. I argue that these texts call attention to women as what ...
Tópico(s): Torture, Ethics, and Law
2017 - Johns Hopkins University Press | Modern fiction studies
Federica Grosso, Roberta Sanfilippo, Emanuela Virdis, C. Piovesan, Paola Collini, Palma Dileo, Carlo Morosi, Juan Carlos Tercero, José Jimeno, Maurizio D’Incalci, Alessandro Gronchi, S. Pilotti, Paolo G. Casali,
Trabectedin has been approved in Europe as second-line therapy for advanced soft tissue sarcomas. A previous analysis showed that myxoid liposarcomas (MLS) are particularly sensitive to the drug. We report on the long-term efficacy of trabectedin in a subgroup of that series.Since September 2002, 32 advanced pretreated MLS patients received trabectedin at our center. Data were reviewed focusing on their long-term outcome.Trabectedin was given as a 24-h continuous infusion every 21 days. A total of ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2009 - Elsevier BV | Annals of Oncology
Produção Nacional
Revisado por pares
William Marciel de Souza, Marcílio Jorge Fumagalli, Matheus Cavalheiro Martini, Jansen de Araújo, Maria Ângela Orsi, Luiz Francisco Sanfilippo, Sejal Modha, Edison Luíz Durigon, José Luiz Proença‐Módena, Clarice Weis Arns, Pablo R. Murcia, Luiz Tadeu Moraes Figueiredo,
Abstract Picornaviridae family comprises single-stranded, positive-sense RNA viruses distributed into forty-seven genera. Picornaviruses have a broad host range and geographic distribution in all continents. In this study, we applied a high-throughput sequencing approach to examine the presence of picornaviruses in penguins from King George Island, Antarctica. We discovered and characterized a novel picornavirus from cloacal swab samples of gentoo penguins (Pygoscelis papua), which we tentatively ...
Tópico(s): Viral Infections and Immunology Research
2019 - University of Oxford | Virus Evolution
Verónica Delgadillo, María del Mar O’Callaghan, Laura Gort, María José Coll, Mercédes Pineda,
Mucopolysaccharidosis type III (MPS III), or Sanfilippo syndrome, is caused by a deficiency in one of the four enzymes involved in the lysosomal degradation of heparan sulphate. Four MPS III types have been recognized, characterized by a large phenotypic heterogeneity. This is the first Spanish study describing the natural history of Sanfilippo patients (MPSIIIA, MPSIIIB and MPSIIIC), representing an essential step for understanding patient prognosis and for the establishment and application of future ...
Tópico(s): Trypanosoma species research and implications
2013 - BioMed Central | Orphanet Journal of Rare Diseases
Federica Grosso, Robin L. Jones, George D. Demetri, Ian Judson, Jean‐Yves Blay, Axel Le Cesne, Roberta Sanfilippo, Paola Casieri, Paola Collini, Palma Dileo, Carlo Spreafico, Silvia Stacchiotti, Elena Tamborini, Juan Carlos Tercero, José Jimeno, Maurizio D’Incalci, Alessandro Gronchi, Jonathan A. Fletcher, Silvana Pilotti, Paolo G. Casali,
Previous studies have suggested that trabectedin (ecteinascidin-743) could have antitumour activity in soft-tissue sarcoma. We aimed to study the usefulness of trabectedin in the treatment of patients with myxoid liposarcomas, a subtype of liposarcoma that is associated with specific chromosomal translocations t(12;16)(q13;p11) or t(12;22)(q13;q12) that result in the formation of DDIT3-FUS or DDIT3-EWSR1 fusion proteins.51 patients with advanced pretreated myxoid liposarcoma who started treatment ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2007 - Elsevier BV | The Lancet Oncology
Produção Nacional
Revisado por pares
Giulianna Baldini, José Fernando Palmejiani, João Pedro Bonevechio Sant'Anna, Zumira Aparecida Carneiro, Roberto Giugliani, Catarina Pereira, Claudia Cozma, Cara O’Neill, Charles Marques Lourenço,
Sanfilippo syndrome or mucopolysaccharidosis III (MPS III), includes a group of four autosomal recessive lysosomal storage disorders caused by deficient activity of enzymes involved in the catabolism of heparan sulfate. The four types of MPS III are recognized in accordance with the deficient enzyme, resulting in the accumulation of heparan sulfate with particularly deleterious effects in the central nervous system. The incidence of MPS III remains to be established in Latin American countries. We ...
Tópico(s): Trypanosoma species research and implications
2020 - SciELO | Journal of Inborn Errors of Metabolism and Screening
P. J. SANFILIPPO, Maud Urbanski, L. Williams, J. Press, L. B. KATZ, D. A. SHRIVER, José A. Fernández, D. SHATYNSKI, S. J. OFFORD,
A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy ...
Tópico(s): Drug Transport and Resistance Mechanisms
1992 - Elsevier BV | European Journal of Medicinal Chemistry
Antoîne Italiano, Armelle Laurand, Audrey Laroche, Paolo G. Casali, Roberta Sanfilippo, Axel Le Cesne, Ian Judson, Jean‐Yves Blay, Isabelle Ray‐Coquard, Binh Bui, Jean‐Michel Coindre, Antonio Nieto, Juan‐Carlos Tercero, José Jimeno, Jacques Robert, Philippe Pourquier,
Abstract BACKGROUND: The objective of this study was to determine whether specific single nucleotide polymorphisms (SNPs) from nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways are associated with sensitivity to trabectedin in patients with soft tissue sarcoma (STS). METHODS: The authors analyzed excision repair cross‐complementation group 5/xeroderma pigmentosum group G ( ERCC5/XPG ) (NER), excision repair cross‐complementation group 1 ( ERCC1 ) (NER), and breast cancer 1 ( ...
Tópico(s): Molecular Biology Techniques and Applications
2011 - Wiley | Cancer
Alessandro Gronchi, Nadia Hindi, Josefina Cruz, Jean-Yves Blay, Antonio López‐Pousa, Antoîne Italiano, Rosa Álvarez, Antonio Gutiérrez, Inmaculada del Rincón, Claudia Sangalli, Jose Luis Pérez Aguiar, Jesús Romero, Carlo Morosi, Marie Pierre Sunyach, Roberta Sanfilippo, Cleofé Romagosa, Dominique Ranchère‐Vince, Angelo Paolo Dei Tos, Paolo G. Casali, Javier Martín‐Broto,
BackgroundMyxoid liposarcoma (ML) exhibits a special sensitivity to trabectedin (T) and radiation therapy (RT). Preclinical data suggest a synergistic effect. We aimed to study safety, feasibility and activity of the administration of pre-operative concurrent T and RT in patients affected by localized resectable ML.MethodsPatients received 3 cycles (C) of T in combination with RT (45 Gy) in 25 fractions (1.8 Gy/fraction). Dose Levels for T were: −1 (1.1 mg/m2), 0 (1.3 mg/m2) and 1 (1.5 mg/m2). Primary endpoint ...
Tópico(s): Cardiac tumors and thrombi
2019 - Elsevier BV | EClinicalMedicine
Roberta Sanfilippo, Nadia Hindi, Josefina Cruz Jurado, Jean‐Yves Blay, Antonio López‐Pousa, Antoîne Italiano, Rosa Álvarez, Antonio Gutiérrez, Inmaculada Rincon-Pérez, Claudia Sangalli, Jose Luis Pérez Aguiar, Jesús Romero, Carlo Morosi, Marie‐Pierre Sunyach, Chiara Fabbroni, Cleofé Romagosa, Dominique Ranchère‐Vince, Angelo Paolo Dei Tos, Paolo G. Casali, Javier Martín‐Broto, Alessandro Gronchi,
Preclinical data about the synergistic activity of radiotherapy (RT) and trabectedin have been reported. The combination of trabectedin and RT in treating myxoid liposarcomas appears worth exploring.
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2023 - American Medical Association | JAMA Oncology
Nicole Muschol, Anja F. Koehn, Katharina von Cossel, İlyas Okur, Fatih Süheyl Ezgü, Paul Harmatz, María José de Castro López, María L. Couce, Shuan‐Pei Lin, Spyros Batzios, Maureen Cleary, Martha Solano, Igor Nestrašil, Bella Kaufman, Adam J. Shaywitz, Stephen M. Maricich, Bernice Kuca, Joseph Kovalchin, Eric Zanelli,
BackgroundSanfilippo type B is a mucopolysaccharidosis (MPS) with a major neuronopathic component characterized by heparan sulfate (HS) accumulation due to mutations in the NAGLU gene encoding alfa-N-acetyl-glucosaminidase. Enzyme replacement therapy for neuronopathic MPS requires efficient enzyme delivery throughout the brain in order to normalize HS levels, prevent brain atrophy, and potentially delay cognitive decline.MethodsIn this phase I/II open-label study, patients with MPS type IIIB (n = 22) ...
Tópico(s): Neonatal and fetal brain pathology
2022 - American Society for Clinical Investigation | Journal of Clinical Investigation
Kevin M. Flanigan, Nicholas Smith, María L. Couce, Deepa Rajan, Kristen V. Truxal, Kim L. McBride, María José de Castro López, Maria Fuller, John Taylor, Ana B. Del Campo, Igor D. Grachev, Heather Lau,
By reducing LDL cholesterol levels, statins may decrease androgen production. This study was aimed at investigating whether testosterone treatment has an impact on cardiometabolic risk factors in statin-treated men with late-onset hypogonadism (LOH).The study included 31 men with LOH who had been treated for at least 6 months with atorvastatin (20–40 mg daily). On the basis of patient preference, atorvastatin-treated patients were divided into two matched groups of patients: receiving intramuscular ...
Tópico(s): Ovarian function and disorders
2023 - Elsevier BV | Molecular Genetics and Metabolism
Stefano Sanfilippo, José Juan Hernández-Gálvez, José Juan Hernández-Cabrera, José Évora-Gómez, Octavio Roncal-Andrés, Mario Caballero-Ramirez,
Tópico(s): Optimal Power Flow Distribution
2025 - IOS Press | Informatica
Kevin M. Flanigan, Nicholas Smith, María L. Couce, Kristen V. Truxal, Kim L. McBride, Tabatha R. Simmons, María José de Castro, Krista A. Cope, Maria Teresa Oreiro, Louise Jaensch, Maria Fuller, Juan Ruiz,
Heparan-α-glucosaminide N-acetyltransferase (HGSNAT) participates in lysosomal degradation of heparan sulfate. Mutations in the gene encoding this enzyme cause mucopolysaccharidosis IIIC (MPS IIIC) or Sanfilippo syndrome type C. MPS IIIC patients exhibit progressive neurodegeneration, leading to dementia and death in early adulthood. Currently there is no approved treatment for MPS IIIC. Incidences of non-syndromic retinitis pigmentosa and early signs of night blindness are reported in some MPS IIIC ...
Tópico(s): Cellular transport and secretion
2020 - Elsevier BV | Molecular Genetics and Metabolism
Nicole Muschol, Maureen Cleary, María L. Couce, Adam J. Shaywitz, Heather Cahan, Anita Grover, Stephen M. Maricich, Andrew C. Melton, Lynn Smith, María José de Castro López,
Tópico(s): Hereditary Neurological Disorders
2018 - Elsevier BV | Molecular Genetics and Metabolism
Antoine Vieillard‐Baron, Scott J. Millington, Filippo Sanfilippo, Michelle S. Chew, José L. Díaz‐Gómez, Anthony S. McLean, Michael R. Pinsky, Juan N. Pulido, Paul H. Mayo, Nick Fletcher,
The original version of this article unfortunately contained a mistake.
Tópico(s): Pericarditis and Cardiac Tamponade
2019 - Springer Science+Business Media | Intensive Care Medicine
Armando Di Nardo, David Baquero Gonzalez, Tom Baur, Romeo Bernini, Sergio F. Bodini, Sante Capasso, Furio Cascetta, Francesca Castaldo, Michele Cocco, Philippe Cousin, Mario D’Acunto, Romeo Di Leo, Bartolomeo Della Ventura, Anna Di Mauro, Michele Di Natale, Guido Di Virgilio, Marco Doveri, Bouâbid El Mansouri, Roberto Germano, Carlo Giudicianni, Nicolas Giunta, Roberto Greco, Pasquale Iovino, Evina Katsou, R. Koenig, Chrysi Laspidou, Vincenzo Lisbino, Lisa Lupi, Eva Martínez Díaz, Dino Musmarra, Montse Mussons Olivella, Osvaldo Paleari, Jordi Raich, Fiona Regan, Manuel J. Rodriguez-Pinzon, José Manuel Rodríguez-Varela, Luca Sanfilippo, Jai Sankar Seelam, Giovanni Francesco Santonastaso, Dragan Savić, Andrea Scozzari, Francesco Soldovieri, Francesco Paolo Tuccinardi, Velitchko Tzatchkov, Lydia Vamvakeridou-Lyroudia, Martin van Rijn, Raffaele Velotta, Salvatore Venticinque, Hans Wouters,
Smart cities are getting essential to drive economic growth, increase social prospects and improve high-quality lifestyle for citizens. To meet the goal of smart cities, Information and Communications Technology (ICT) have a key role. The application of smart solutions will allow the cities to use ICT and big data to improve infrastructure and services (i.e. network efficiency, protection from contamination, etc.). In the water sector, the integration of smart meters and sensors coupled with cloud ...
Tópico(s): Air Quality Monitoring and Forecasting
2018 - | EPiC series in engineering
Tópico(s): Ethics and bioethics in healthcare
2009 - National University of Colombia | Revista de la Facultad de Medicina
Durante este siglo, la investigacion historico-medica ha tenido un gran desarrollo en nuestro pais. Muchas son las orientaciones que ha seguido y muchos los que han aportado importantes contribuciones para el conocimiento de nuestro pasado medico.
Tópico(s): Medicine and Dermatology Studies History
1991 - National University of Colombia | Revista de la Facultad de Medicina
Tópico(s): Early Modern Spanish Literature
1991 - | Revista de la Asociación Dental Mexicana
Tópico(s): Psidium guajava Extracts and Applications
1994 - | CIENCIA & DESARROLLO
Josefina Torres Galán, José Sanfilippo y Borrás,
Durante el siglo XIX en la ciudad de Mexico la atencion a los pacientes hospitalizados y convalecientes en su domicilio, fue realizado por clerigos y monjas, con el apoyo de mujeres contratadas como sirvientas. En 1888 la Escuela Nacional de Medicina pretende, sin exito, establecer una escuela de enfermeria; se retomo la idea diez anos mas tarde, con la contratacion de enfermeras estadounidenses, quienes dieron inicio a la lucha presentada por las enfermeras del Hospital General de Mexico para ser ...
Tópico(s): Mexican Socioeconomic and Environmental Dynamics
2016 - Universidad Michoacana de San Nicolás de Hidalgo | Tzintzun. revista de estudios históricos
Josefina Torres, Ricardo Gallardo, José Sanfilippo,
Las mujeres se preocuparon y ocuparon del conocimiento de las hierbas y los animales en sus usos alimenticio y medicinal, así como del desafío presentado para ser aceptadas como alumnas de la Escuela Nacional de Medicina en una de las áreas de las ciencias de la salud que ejercían empíricamente: la farmacéutica. En el siglo XIX las curanderas y herbolarias eran consideradas en dos vertientes: como la mujer sabia, la sanadora, y como la hechicera capaz de hacer maleficios. In Search of Medical Science: ...
Tópico(s): Culinary Culture and Tourism
2016 - | Letras Históricas
Josefina Torres, Ricardo Gallardo, José Sanfilippo,
Las mujeres se preocuparon y ocuparon del conocimiento de las hierbas y los animales en sus usos alimenticio y medicinal, así como del desafío presentado para ser aceptadas como alumnas de la Escuela Nacional de Medicina en una de las áreas de las ciencias de la salud que ejercían empíricamente: la farmacéutica. En el siglo XIX las curanderas y herbolarias eran consideradas en dos vertientes: como la mujer sabia, la sanadora, y como la hechicera capaz de hacer maleficios. In Search of Medical Science: ...
Tópico(s): Culinary Culture and Tourism
2016 - | Letras Históricas
Tópico(s): Dental Education, Practice, Research
1998 - | Revista de la Asociación Dental Mexicana
José Avendaño‐Ortiz, Raquel Barbero Herranz, Guillem Pintos‐Morell, Esther Palacios, Amalio Blanco, Beatriz Arconada, Pedro Ruiz‐Sala, Amaya Bélanger-Quintana, Sinziana Stanescu, María Garriga-García, Rosa del Campo,
Tópico(s): Whipple's Disease and Interleukins
2025 - Elsevier BV | Molecular Genetics and Metabolism