Nicole L. Davis, William C. Miller, Michael G. Hudgens, Charles S. Chasela, Dorothy Sichali, Dumbani Kayira, Julie A. Nelson, Susan A. Fiscus, Gerald Tegha, Deborah Kamwendo, Joseph Rigdon, Jeffrey S. A. Stringer, Jonathan J. Juliano, Sascha Ellington, Athena P. Kourtis, Denise J. Jamieson, Charles van der Horst,
Antiretroviral (ARV) interventions are used to reduce HIV viral replication and prevent mother-to-child transmission. Viral suppression relies on adherence to ARVs.
Tópico(s): HIV-related health complications and treatments
2016 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
James G. Kublin, Fraction K. Dzinjalamala, Deborah Kamwendo, Elissa Malkin, Joseph F. Cortese, Lisa M. Martino, Rabia A. G. Mukadam, Stephen J. Rogerson, Andrés G. Lescano, Malcolm E. Molyneux, Peter Winstanley, Phillips Chimpeni, Terrie E. Taylor, Christopher V. Plowe,
Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium falciparum have not been implemented because of the genetic and statistical complexity of the parasite mutations that confer resistance and their relation to treatment outcomes. This study analyzed pretreatment dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) genotypes and treatment outcomes in a double-blind, placebo-controlled trial of sulfadoxine-pyrimethamine and chlorproguanildapsone treatment for ...
Tópico(s): Malaria Research and Control
2002 - Oxford University Press | The Journal of Infectious Diseases
David R Ellard, Doug Simkiss, Siobhan Quenby, David Davies, Ngianga‐Bakwin Kandala, Francis Kamwendo, Chisale Mhango, Joseph Paul O’Hare,
Maternal mortality in much of sub-Saharan Africa is very high whereas there has been a steady decline in over the past 60 years in Europe. Perinatal mortality is 12 times higher than maternal mortality accounting for about 7 million neonatal deaths; many of these in sub-Saharan countries. Many of these deaths are preventable. Countries, like Malawi, do not have the resources nor highly trained medical specialists using complex technologies within their healthcare system. Much of the burden falls ...
Tópico(s): Global Health and Surgery
2012 - BioMed Central | BMC Pregnancy and Childbirth
Mina C. Hosseinipour, Joep JG van Oosterhout, Ralf Weigel, Sam Phiri, Debbie Kamwendo, Neil Parkin, Susan A. Fiscus, Julie A. Nelson, Joseph J. Eron, Johnstone Kumwenda,
Over 150,000 Malawians have started antiretroviral therapy (ART), in which first-line therapy is stavudine/lamivudine/nevirapine. We evaluated drug resistance patterns among patients failing first-line ART on the basis of clinical or immunological criteria in Lilongwe and Blantyre, Malawi.Patients meeting the definition of ART failure (new or progressive stage 4 condition, CD4 cell count decline more than 30%, CD4 cell count less than that before treatment) from January 2006 to July 2007 were evaluated. ...
Tópico(s): HIV Research and Treatment
2009 - Lippincott Williams & Wilkins | AIDS
David R Ellard, Wanangwa Chimwaza, David Davies, Joseph Paul O’Hare, Francis Kamwendo, Siobhan Quenby, Frances Griffiths,
The 'enhancing human resources and the use of appropriate technologies for maternal and perinatal survival in sub-Saharan Africa' (ETATMBA) project is training emergency obstetric and new-born care (EmONC) non-physician clinicians (NPCs) as advanced clinical leaders. Our objectives were to evaluate the implementation and changes to practice.A mixed methods process evaluation with the predominate methodology being qualitative.Rural and urban hospitals in 8 of the 14 districts of northern and central ...
Tópico(s): Emergency and Acute Care Studies
2014 - BMJ | BMJ Open
Stefan Witek-McManus, James Simwanza, Alvin Chisambi, Stella Kepha, Zachariah Kamwendo, Alfred Mbwinja, Lyson Samikwa, William E. Oswald, David S. Kennedy, Joseph Timothy, Hugo Legge, Sean R. Galagan, Mira Emmanuel-Fabula, Fabian Schaer, Kristjana Ásbjörnsdóttir, Katherine E. Halliday, Judd L. Walson, Lazarus Juziwelo, Robin L. Bailey, Khumbo Kalua, Rachel L. Pullan,
Malawi has successfully leveraged multiple delivery platforms to scale-up and sustain the implementation of preventive chemotherapy (PCT) for the control of morbidity caused by soil-transmitted helminths (STH). Sentinel monitoring demonstrates this strategy has been successful in reducing STH infection in school-age children, although our understanding of the contemporary epidemiological profile of STH across the broader community remains limited. As part of a multi-site trial evaluating the feasibility ...
Tópico(s): Parasite Biology and Host Interactions
2021 - Public Library of Science | PLoS neglected tropical diseases
Jesse C. Nussbaum, Arthur Jackson, Dan Namarika, Jacob Phulusa, Jullita Kenala, Creto Kanyemba, Joseph N Jarvis, Shabbar Jaffar, Mina C. Hosseinipour, Deborah Kamwendo, Charles M. van der Horst, Thomas S. Harrison,
Background. Cryptococcal meningitis is a major cause of human immunodeficiency virus (HIV)–associated morbidity and mortality in Africa. Improved oral treatment regimens are needed because amphotericin B is neither available nor feasible in many centers. Fluconazole at a dosage of 1200 mg per day is more fungicidal than at a dosage of 800 mg per day, but mortality rates remain unacceptably high. Therefore, we examined the effect of adding oral flucytosine to fluconazole. Methods. From 13 February ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2009 - Oxford University Press | Clinical Infectious Diseases
David R Ellard, Wanangwa Chimwaza, David Davies, Doug Simkiss, Francis Kamwendo, Chisale Mhango, Siobhan Quenby, Ngianga‐Bakwin Kandala, Joseph Paul O’Hare,
The ETATMBA (Enhancing Training And Technology for Mothers and Babies in Africa) project-trained associate clinicians (ACs/clinical officers) as advanced clinical leaders in emergency obstetric and neonatal care. This trial aimed to evaluate the impact of training on obstetric health outcomes in Malawi.A cluster randomised controlled trial with 14 districts of Malawi (8 intervention, 6 control) as units of randomisation. Intervention districts housed the 46 ACs who received the training programme. ...
Tópico(s): Global Health Workforce Issues
2016 - BMJ | BMJ Global Health
Christopher J. Sellers, Hana Lee, Charles Chasela, Dumbani Kayira, Alice Soko, Innocent Mofolo, Sascha Ellington, Michael G. Hudgens, Athena P. Kourtis, Caroline C. King, Denise J. Jamieson, Charles van der Horst, Linda S. Adair, Yusuf Ahmed, Mounir Ait‐Khaled, Sandra S. Albrecht, Shrikant I. Bangdiwala, Ronald Bayer, Margaret E. Bentley, Brian Bramson, Emily Bobrow, Nicola Boyle, Sal Butera, Charles Chasela, Charity Chavula, Joseph Chimerang’ambe, Maggie Chigwenembe, Maria Chikasema, Norah Chikhungu, David Chilongozi, Grace Chiudzu, Lenesi Chome, Anne Jodon Cole, Amanda Corbett, Amy Corneli, Anna Dow, Ann Duerr, Henry Eliya, Sascha Ellington, Joseph J. Eron, Sherry L. Farr, Yvonne Owens Ferguson, Susan A. Fiscus, Valerie L. Flax, Ali Fokar, Shannon Galvin, Laura Guay, Charles M. Heilig, Irving Hoffman, Elizabeth Gerken Hooten, Mina C. Hosseinipour, Michael G. Hudgens, Stacy Hurst, Lisa Hyde, Denise J. Jamieson, George Joaki, David Jones, Elizabeth Jordan-Bell, Zebrone Kacheche, Esmie Kamanga, Gift Kamanga, Coxcilly Kampani, Portia Kamthunzi, Deborah Kamwendo, Cecilia Kanyama, Angela D. M. Kashuba, Damson Kathyola, Dumbani Kayira, Peter N. Kazembe, Caroline C. King, Rod Knight, Athena P. Kourtis, Robert Krysiak, Jacob Kumwenda, Hana Lee, Edde Loeliger, Dustin Long, Misheck Luhanga, Victor Madhlopa, Maganizo Majawa, Alice Maida, Cheryl Marcus, Francis Martinson, Navdeep Thoofer, Chrissie Matiki, Douglas L. Mayers, Isabel Mayuni, Marita McDonough, Joyce Meme, Ceppie Merry, Khama Mita, Chimwemwe Mkomawanthu, Gertrude Mndala, Ibrahim Mndala, Agnes Moses, Albans Msika, Wezi Msungama, Beatrice Mtimuni, Jane Muita, Noel Mumba, Bonface Musis, Charles Mwansambo, Gerald Mwapasa, Jacqueline Nkhoma, Megan Parker, Richard Pendame, Ellen Piwoz, Byron Raines, Zane Ramdas, John Rublein, Máirín Ryan, Ian Sanne, Christopher Sellers, Diane C. Shugars, Dorothy Sichali, Wendy Snowden, Alice Soko, Allison Spensley, Jean-Marc Steens, Gerald Tegha, Martin Tembo, Roshan M Thomas, Hsiao-Chuan Tien, Beth Carlton Tohill, Charles van der Horst, Esther Waalberg, Elizabeth M. Widen, Jeffrey Wiener, Cathy Wilfert, Patricia Wiyo, Innocent Zgambo, Chifundo Zimba,
Background/Aims Retaining patients in prevention of mother-to-child transmission of HIV studies can be challenging in resource-limited settings, where high lost to follow-up rates have been reported. In this article, we describe the effectiveness of methods used to encourage retention in the Breastfeeding, Antiretrovirals, and Nutrition study and analyze factors associated with lost to follow-up in the study. Methods The Breastfeeding, Antiretrovirals, and Nutrition clinical trial was designed to ...
Tópico(s): HIV Research and Treatment
2014 - SAGE Publishing | Clinical Trials
Nicole L. Davis, Jeffrey Wiener, Jonathan J. Juliano, Linda S. Adair, Charles S. Chasela, Dumbani Kayira, Michael G. Hudgens, Charles van der Horst, Denise J. Jamieson, Athena P. Kourtis, Linda S. Adair, Yusuf Ahmed, Mounir Ait‐Khaled, Sandra S. Albrecht, Shrikant I. Bangdiwala, Ronald Bayer, Margaret E. Bentley, Brian Bramson, Emily Bobrow, Nicola Boyle, Sal Butera, Charles S. Chasela, Charity Chavula, Joseph Chimerang’ambe, Maggie Chigwenembe, Maria Chikasema, Norah Chikhungu, David Chilongozi, Grace Chiudzu, Lenesi Chome, Anne Cole, Amanda Corbett, Amy Corneli, Anna Dow, Ann Duerr, Henry Eliya, Sascha Ellington, Joseph J. Eron, Sherry L. Farr, Yvonne Owens Ferguson, Susan A. Fiscus, Valerie L. Flax, Ali Fokar, Shannon Galvin, Laura Guay, Charles M. Heilig, Irving Hoffman, Elizabeth Gerken Hooten, Mina C. Hosseinipour, Michael Hudgens, Stacy Hurst, Lisa Hyde, Denise J. Jamieson, George Joaki, David E. Jones, Elizabeth Jordan-Bell, Zebrone Kacheche, Esmie Kamanga, Gift Kamanga, Coxcilly Kampani, Portia Kamthunzi, Deborah Kamwendo, Cecilia Kanyama, Angela D. M. Kashuba, Damson Kathyola, Dumbani Kayira, Peter N. Kazembe, Caroline C. King, R. J. Knight, Athena P. Kourtis, Robert Krysiak, Jacob Kumwenda, Hana Lee, Edde Loeliger, Dustin Long, Misheck Luhanga, Victor Madhlopa, Maganizo Majawa, Alice Maida, Cheryl Marcus, Francis Martinson, Navdeep Thoofer, Chrissie Matiki, Douglas L. Mayers, Isabel Mayuni, Marita McDonough, Joyce Meme, Ceppie Merry, Khama Mita, Chimwemwe Mkomawanthu, Gertrude Mndala, Ibrahim Mndala, Agnes Moses, Albans Msika, Wezi Msungama, Beatrice Mtimuni, Jane Muita, Noel Mumba, Bonface Musis, Charles Mwansambo, Gerald Mwapasa, Jacqueline Nkhoma, Megan Parker, Richard Pendame, Ellen Piwoz, Byron Raines, Zane Ramdas, John Rublein, Máirín Ryan, Ian Sanne, Christopher J. Sellers, Diane C. Shugars, Dorothy Sichali, Wendy Snowden, Alice Soko, Allison Spensley, Jean-Marc Steens, Gerald Tegha, Martin Tembo, Roshan K. Thomas, Hsiao-Chuan Tien, Beth Carlton Tohill, Charles van der Horst, Esther Waalberg, Elizabeth M. Widen, Jeffrey Wiener, Cathy Wilfert, Patricia Wiyo, Innocent Zgambo, Chifundo Zimba,
Human immunodeficiency virus (HIV)-exposed infants are disproportionately at risk of morbidity and mortality compared with their HIV-unexposed counterparts. The role of co-trimoxazole preventive therapy (CPT) in reducing leading causes of infectious morbidity is unclear.We used data from the Breastfeeding, Antiretrovirals and Nutrition (BAN) clinical trial (conducted 2004-2010, Malawi) to assess the association of (1) CPT and (2) asymptomatic malaria parasitemia with respiratory and diarrheal morbidity ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2017 - Oxford University Press | Clinical Infectious Diseases
... Rüdiger Köppe. Monaka, Kemmonye C. and Gregory. H. Kamwendo. 2007. Linguistic minorities and marginalization in Botswana: Prospects ...
Tópico(s): Multilingual Education and Policy
2009 - Wiley | Language and Linguistics Compass