Book.
0000 - Gale Group | SASII
... business ”.1 The large Dublin merchant house of Joshua & Joseph Pim discounted bills on a very extensive scale. In ...
Tópico(s): Irish and British Studies
1958 - Wiley | Economica
Amand F. Schmidt, Mimount Bourfiss, Abdulrahman Alasiri, Esther Puyol‐Antón, Sandesh Chopade, Marion van Vugt, Sander W. van der Laan, Christian Groß, Chris Clarkson, Albert Henry, Tom Lumbers, Pim van der Harst, Nora Franceschini, Joshua C. Bis, Birgitta K. Velthuis, Anneline S.J.M. te Riele, Aroon D. Hingorani, Bram Ruijsink, Folkert W. Asselbergs, Jessica van Setten, Chris Finan,
Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular function and structure.
Tópico(s): Cardiomyopathy and Myosin Studies
2023 - American Association for the Advancement of Science | Science Advances
Lloyd, Ernest Newman, Frederick Grundy, A. B., F. W. D. Mitchell, A. Podmore, E. N., Charles Marshall, Yarborough, Vera I. Arlett, P. P. C., T. P. O'connor M. P., Sir W. Plender's, Another Englishman, C. Harrison, Alfred B. Beaven, Frank Rutter, Joseph G. Ward, De F. Pennefather, Arthur Kitson, Edmund Gosse, Sydney W. Carroll, Mayfair, H. C. Minchin, Mark S. Poore, Roland Atkinson, D. R. G., L. Van Vliet, Crawfurd Price, H. L. R., Baron Von Eckardstein, S. D. B., Hannen Swaffer, Alfred Larke, Dr. J. M. Bulloch, Geo W. Hersey, Pandora, Gerald Biss, Henry O. Forbes, A. Brodie Fraser, R. J. Barrett Financial Editor, Harold Cox,
... S. R. Littlowood. (O'Connor. 10s. 6d.) Mr. Pim. By A. A. Milne. (Hodder and Stoughton. 7s. ...
1921 - Gale Group | Sunday Times HA GDA
Andrew R. Wood, Tõnu Esko, Jian Yang, Sailaja Vedantam, Tune H. Pers, Stefan Gustafsson, Audrey Y. Chu, Karol Estrada, Jian’an Luan, Zoltán Kutalik, Najaf Amin, Martin L. Buchkovich, Damien C. Croteau‐Chonka, Felix R. Day, Yanan Duan, Tove Fall, Rudolf S.N. Fehrmann, Teresa Ferreira, Anne Jackson, Juha Karjalainen, Ken Sin Lo, Adam E. Locke, Reedik Mägi, Evelin Mihailov, Eleonora Porcu, Joshua C. Randall, André Scherag, Anna A. E. Vinkhuyzen, Harm-Jan Westra, Thomas W. Winkler, Tsegaselassie Workalemahu, Wei Zhao, Devin Absher, Eva Albrecht, Denise Anderson, Jeffrey Baron, Marian Beekman, Ayşe Demirkan, Georg Ehret, Bjarke Feenstra, Mary F. Feitosa, Krista Fischer, Ross M. Fraser, Anuj Goel, Jian Gong, Anne E. Justice, Stavroula Kanoni, Marcus E. Kleber, Kati Kristiansson, Unhee Lim, Vaneet Lotay, Julian C. Lui, Massimo Mangino, Irene Mateo Leach, Carolina Medina‐Gómez, Michael A. Nalls, Dale R. Nyholt, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Inga Prokopenko, Janina S. Ried, Stephan Ripke, Dmitry Shungin, Alena Stančáková, Rona J. Strawbridge, Yan V. Sun, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Jessica van Setten, Jana V. van Vliet‐Ostaptchouk, Thomas J. Wang, Loïc Yengo, Weihua Zhang, Uzma Afzal, Johan Ärnlöv, Gillian M. Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J. Bennett, Christian Berne, Matthias Blüher, Jennifer L. Bolton, Yvonne Böttcher, Heather A. Boyd, Marcel Bruinenberg, Brendan M. Buckley, Steven Buyske, Ida Henriette Caspersen, Peter S. Chines, Robert Clarke, Xueling Sim, Matthew N. Cooper, E. Warwick Daw, Pim A. de Jong, Joris Deelen, Graciela Delgado, Joshua C. Denny, R.A.M. Dhonukshe-Rutten, Maria Dimitriou, Alex S. F. Doney, Marcus Dörr, Niina Eklund, Elodie Eury, Lasse Folkersen, Melissa E. Garcia, Frank Geller, Vilmantas Giedraitis, Alan S. Go, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Henrik Grönberg, C.P.G.M. de Groot, Christopher J. Groves, Jeffrey Haessler, Per Hall, Toomas Haller, Göran Hallmans, Anke Hannemann, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Nancy L. Heard‐Costa, Quinta Helmer, Gibran Hemani, Anjali K. Henders, Hans L. Hillege, Mark A. Hlatky, Wolfgang Hoffmann, Per Hoffmann, Oddgeir L. Holmen, Jeanine J. Houwing‐Duistermaat, Thomas Illig, Aaron Isaacs, Anthony James, Janina M. Jeff, Berit Johansen, Åsa Johansson, Jennifer Jolley, Thorhildur Juliusdottir, Juhani Junttila, Abel Kho, Leena Kinnunen, Norman Klopp, Thomas Köcher, Wolfgang Kratzer, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, Yingchang Lu, Valeriya Lyssenko, Patrik K. E. Magnusson, Anubha Mahajan, Marc Maillard, Wendy L. McArdle, Colin A. McKenzie, Stela McLachlan, Paul J. McLaren, Cristina Menni, Sigrun Merger, Lili Milani, Alireza Moayyeri, Keri L. Monda, Mario A. Morken, Gabriele Müller, Martina Müller‐Nurasyid, Arthur W. Musk, Narisu Narisu, Matthias Nauck, Ilja M. Nolte, Markus M. Nöthen, Laticia Oozageer, Stefan Pilz, Nigel W. Rayner, Frida Renström, Neil R. Robertson, Lynda M. Rose, Ronan Roussel, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Fredrick R. Schumacher, Heribert Schunkert, Robert A. Scott, Joban Sehmi, Thomas Seufferlein, Jianxin Shi, Karri Silventoinen, Johannes H. Smit, Albert V. Smith, Joanna Smolonska, Alice Stanton, Kathleen Stirrups, David J. Stott, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Ann-Christine Syvänen, Bamidele O. Tayo, Guðmar Þorleifsson, Jonathan P. Tyrer, Suzanne van Dijk, Natasja M. van Schoor, Nathalie van der Velde, Diana van Heemst, Floor V. A. van Oort, Sita H. Vermeulen, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Mélanie Waldenberger, Roman Wennauer, Lynne R. Wilkens, Christina Willenborg, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Alan F. Wright, Qunyuan Zhang, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Dorret I. Boomsma, Stefan R. Bornstein, Pascal Bovet, Paolo Brambilla, Matthew A. Brown, Harry Campbell, Mark J. Caulfield, Aravinda Chakravarti, Rory Collins, Francis S. Collins, Dana C. Crawford, L. Adrienne Cupples, John Danesh, Ulf dé Fairé, Hester M. den Ruijter, Raimund Erbel, Jeanette Erdmann, Johan G. Eriksson, Martin Farrall, Ele Ferrannini, Jean Ferrières, Ian Ford, Nita G. Forouhi, Terrence Forrester, Ron T. Gansevoort, Pablo V. Gejman, Christian Gieger, Alain Golay, Omri Gottesman, Vilmundur Guðnason, Ulf Gyllensten, David W. Haas, Alistair S. Hall, Tamara B. Harris, Andrew T. Hattersley, Andrew C. Heath, Christian Hengstenberg, Andrew A. Hicks, Lucia A. Hindorff, Aroon D. Hingorani, Albert Hofman, G. Kees Hovingh, Steve E. Humphries, Steven C. Hunt, Elina Hyppönen, Kevin B. Jacobs, Marjo‐Riitta Järvelin, Jari Lahti, Antti Jula, Jaakko Kaprio, John J.P. Kastelein, Manfred Kayser, Frank Kee, Sirkka Keinänen‐Kiukaanniemi, Lambertus A. Kiemeney, Jaspal S. Kooner, Charles Kooperberg, Seppo Koskinen, Péter Kovács, Aldi T. Kraja, Meena Kumari, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg,
Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait. Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained ...
Nature Portfolio
Frederick Grundy, C. R. Johns, Walter Melville, Frederick W. Tattersall, Albert R. De Courville, A. H. Ardeshir, T. U. C. Harris, Joseph Weathers, Sydney Carroll, Geo. T. Jolland, R., Hugh Blaker, Lieut.-Col Sergius Cyon, A. Montague Jordan, Bronson Albery, Frank Rutter, F. R., E. D. Cuming, John Murray Editor of "Boxing", Edward Marshall, Edmund Gosse, Edward Shillito, D. R. Gent, Rt. J. H. Thomas M. P., R. E., S. M. Ellis, Frederick Smith, Robert Cecil Chairman, H. S. Dickin, R. K. R., Paul Hyacinthe Loyson, H. H. Hilton, Mr. A. A. Milne, Harold J. Brough, L. Van Vliet, Spenser Wilkinson, Crawfurd Price, Othmyn, Wilfrid Blair, R. N. Green-Armytage, Gunner C. H. H., W. D. Fish, H. V. Willoughby, J. G. Walker, Gerald Biss, H. B. D., Stanley Naylor, Major-General Sir Chas. Townshend K. C. B., Mr. Ex-Colonel, R. J. Barrett Financial Editor, H. G. S., Harold Cox,
... James' Julius Cæsar. Revived Friday, January 9 "Mr. Pim Passes by" New Comedy by Mr. A. A. ... Tipsters "Daily Mail Year Book" Williamson & Cole Ltd Joshua Hoyle & Sons, Ltd Never Drug a Clogged Liver— ...
1920 - Gale Group | Sunday Times HA GDA
Joshua S. Krumenacker, Vishal S. Narang, Donna J. Buckley, Arthur R. Buckley,
Sublines of the lactogen-dependent, rat pre-T Nb2 lymphoma are useful as a model for the investigation of prolactin (PRL) signaling mechanisms, regulation of transcription of target genes, and the immunomodulatory and anti-apoptotic actions of the hormone in T lymphocytes. In the present study, coupling of various tyrosine, serine/threonine, and phospholipid kinase signaling mechanisms to PRL-stimulated Nb2-11 cell proliferation and expression of the protooncogene, pim-1, was investigated utilizing ...
Tópico(s): Peptidase Inhibition and Analysis
2001 - Elsevier BV | Journal of Neuroimmunology
Major-Gen. Dunsterville C. B., Edward P. Smart, Gilbert Dalziel, Percy Hurd M. P., (Mrs) Helen Symth, A. W. Bume, James Agate, Lowell Brentano, Douglas Harrison, R. P. Mander, Mr. Frank Workman, Leon Bertrand, Hugh Macnaghten, Thomas Johnstone, T. Warwick Preston M. D., D. McMANUS, Rowland H. Hill, Mr. MacDonald, Henry Murray, Mr. Cook, Mr. Remer, Norah Richardson, X. Y. Z., Sir Walter Gilbey, K. C. B., James Strong, J. A. Stuart, Trelawny Roberts, Francis P. Marchant, Frank Rutter, Mr. A. A. Milne's Comedy, D. R. Gent, T. J. Gallwey, Philip Morrell, H. Foster Librarian, Roland Atkinson, Ernest Stock, H. F., Lord Robert Montagu, Pandora, K. C., Rt. Hon. T. P O'Connor M. P., Paul Faraday, Ernest Newman, Sir Henry Rew, A. A. Milne, David Urquhart, Sir Austen, Samuel Heliner, E. V. Lucas, Edith Cleverly, J. Kennedy Allerton, A. A. F, Edmund Gosse, Sydney W. Carroll, Scrutator, H. Maud Ffooks, Dilys Powell, Hilton, Rt. Hon. T. P. O'connor, W. Castle Railton, P. C. Rushen, R. J. Barrett Financial Editor, W. J. Stevens, Sir John Marriott M. P., Charles Bennett, E. Ruggles-Brise, J. H. Morgan, W. H. Devenish, F. R. Cave, David Salmon, Frederick Annesley, Andrew Leigh, Vigilant, George C. Stead, Mayfair, M. A. Heaton, H. C. Minchin, Fulton Oursler, Sir A. Chamberlain, L. Van Vliet, Josephine Butler, Harold Cox,
... Feb. 28 A Play. By Charles Bennett "Mr. Pim Passes by" St. Martin's. Tues. Afternoon, Feb. ... Your Sick Child is Constipated! Look at Tongue Joshua Hoyle & Sons, Ltd. Reville 1926 Ltd. Vote Day ...
1928 - Gale Group | Sunday Times HA GDA
Roel L.F. van der Palen, Alex J. Barker, Émilie Bollache, Julio García, Michael J. Rose, Pim van Ooij, Luciana Young, Arno A.W. Roest, Michael Markl, Joshua D. Robinson, Cynthia K. Rigsby,
Blood flow dynamics make it possible to better understand the development of aortopathy and cardiovascular events in patients with Marfan syndrome (MFS). Aortic 3D blood flow characteristics were investigated in relation to aortic geometry in children and adolescents with MFS. Twenty-five MFS patients (age 15.6 ± 4.0 years; 11 females) and 21 healthy controls (age 16.0 ± 2.6 years; 12 females) underwent magnetic resonance angiography and 4D flow CMR for assessment of thoracic aortic size and 3D blood flow ...
Tópico(s): Cardiac Valve Diseases and Treatments
2016 - BioMed Central | Journal of Cardiovascular Magnetic Resonance
Andrew Robson, Simon Barnes Chief Sports Writer, Alyn Shipton, Lea Paterson and Clive Mathieson, D. R. Cooper, Peter Huck, Rosemary Righter, Jon Ashworth, Daniel Goldberg, Widget Finn, Raymond Snoddy Media Editor, M. A. Faraday, Andrew Pierce, DJM, Alexandra Frean, Zahid Hussain, Adam Sherwin Media Reporter, Frances Gibb Legal Editor, John Stewart, Magnus Linklater, Alex Pine, Tom Walters, Mark Souster, Mike Petrook, Caroline Merrell and Abigail Rayner, John Wilks, Richard Hobson, Ivo Tennant, Michael Evans Defence Editor, Philip Howard, Ian Cobain, David Chater, Joanna Bale, Penny Wark, Bill Bond, Dennis Palmer, Richard Irving, Barbara Ellen, Geoff Brown, Sam Lister, Joe Joseph, Andrew Norfolk, Peter Brown, Antonia Senior, Martin Fletcher, Ben Webster Transport Correspondent, Pat Gibson, Valerie Elliott Countryside Editor, David McVay, Tom Baldwin and Helen Studd, Steve Keenan, Thrasy Petropoulos, Jennai Cox Fitness Editor, Jack Malvern, Dominic Walsh, Erica Wagner Literary Editor, Rory Watson, Gary Jacob, Bobby Robson, Daniel Finkelstein, Philip Jacobson and Susan MacDonald, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Richard Ford Home Correspondent, Alan Hamilton, Stephen Farrell, Rodney Milnes, John O'Leary, Anatole Kaletsky, James Johnston, David Hands, Charles Bremner, Helen Rumbelow, Matt Dickinson Chief Football Correspondent, Nicholas Wapshott, Stuart Crainer, Rex S. Gordon, Angela Jameson, Vanora Bennett, John Fazackerley, Richard Beeston Diplomatic Editor and Stephen Farrell, Oliver Kay, Simon Gell, Tom Baldwin, Stephen Burgen, Mark Henderson Science Correspondent, Jill Sherman Whitehall Editor, Ann Treneman, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Richard Beeston and Stephen Farrell, Neil Harman Tennis Correspondent, Raymond Keene, John Boardman, Greg Hurst Parliamentary Correspondent, Neville Scott, Jeremy Harrison, George Bickerstaffe, Bronwen Maddox, Russell Hotten, Richard Owen, John Willcock, Christopher Martin-Jenkins Chief Cricket Correspondent, Robert Adam, Roger Boyes, Oliver August, Dennis L. Bird, Nigel G. Meek, Nick Hasell, Sean Thomas, Updesh Kapur, David Hands Rugby Correspondent, Paul Simons, Glen Owen, Adam Fresco, John Goodbody, James Doran, Melissa Kite Political Correspondent, Giles Whittell, Philip Webster Political Editor, Carlotta Gall, Ian Johns, Henry Thompson, Des Dearlove, Chris McGrath, Russell Jenkins, Glen Owen Education Correspondent, Ingrid Mansell, John Shaw, Alan Lee, Michael Austin, Joshua Rowe, Stephen Hoare, Peter Riddell, Ben MacIntyre, Tony Dawe, Roger Scrupton, David Charter Chief Political Correspondent, Chris Quick, David Sinclair, Gary Duncan Economics Correspondent, Mark Henderson, Catherine Philp, Martin Waller, Chris Ayres, Pehr Gyllenhammar, Rana Sabbagh-Gargour, Adrian Sanderson, Carl Mortished International Business Editor, Amanda Kelly, Daniel Rosenthal, Benedict Nightingale, Dr Thomas Stuttaford, Vera Vaughn-Bowden, Stephen Dalton, Jack Bailey, Richard Morrison, Tom Chesshyre, James Christopher, Jonathan Margolls, Michael Evans, Craig Stewart, Michael Brown, Nunzio Quacquarelli, Patience Wheatcroft, Christopher Irvine, David Lister Ireland Correspondent,
... Airport congestion National Trust costs The assassination of Pim Fortuyn Who was flying the flag for Israel? ...
2002 - Gale Group | TDA
Joshua S. Krumenacker, Donna J. Buckley, Matthew A. Leff, John T. McCormack, Gary de Jong, Peter W. Gout, John C. Reed, Toshiyuki Miyashita, Nancy S. Magnuson, Arthur R. Buckley,
Tópico(s): Signaling Pathways in Disease
1998 - Springer Science+Business Media | Endocrine
Captain W. De W. Abney, Dr. J. M. Eder, Colonel J. Waterhouse, Dr. H. W. Vogel, H. P. Robinson, W. S. Bird, Professor W. K. Burton, C. H. Bothamley, Leon Vidal, Andrew Pringle, F. York, G. M. Whipple, Sir H. Trueman Wood, George Davison, Sir David Salomons, J. W. Swan, Francis Cobb, Paul Lange, Greenwood Pim, J. Vincent Elsden, John Spiller, Arnold Spiller, Dr. T. L. Phipson, Colonel W. L. Noverre, Wm. Lang Jr., R. P. Drage, Rev. F. C. Lambert, J. Werge, C. Fleetwood Pritchard, Frederick H. Varley, W. E. Debenham, C. Ray Woods, Hermann E. Gunther, James Mew, C. J. Chesterman, Dr. Henri Van Heurck, F. Goldby, Stanley Barnard, T. C. Hepworth, T. Charters White, W. H. Plaister, Birt Acres, W. T. Wilkinson, G. W. Valentine, Charles Whiting, W. Fenton Jones, S. R. Bottone, H. Colebrook, H. J. Burton, Cameron Swan, A. Clarke, William Ayres, T. E. Huston, John Davidson, John Harmer, F. W. Purton, Victor A. L. E. Corbould, J. C. Hannyngton, Thomas Gulliver, Richard Parr, Arthur Ernest Whiting, Charles S. Patterson, J. A. Campbell Murray, Joseph H. Smith, J. M. Brownlee, Edmund E. Fearn, F. T. Bennett, Alfred Watkins, Thomas Gulliver, W. Mathews, J. T. Hackett, George Brown, Robert K. R. Flamank, James A. Gee, William Mayland, C. F. Cross, Ad. Turcke, Henry Platt, Rev. H. Gordon Palmer, Mr. F. H. Varley,
... Optimus' Revolving Print and Negative Washer, Wratten & Wainwright, Joshua Billcliff, Mawson & Swan's Plates and Papers, The ...
1891 - Gale Group | NCCO Photography
Joshua James Morigi, Phillip D. Stricker, Pim J. van Leeuwen, Reuben Tang, Bao Ho, Quoc Nguyen, George Hruby, Gerald Fogarty, Raj Jagavkar, Andrew Kneebone, Adam Hickey, Stefano Fanti, Lisa Tarlinton, Louise Emmett,
In prostate cancer with biochemical failure after therapy, current imaging techniques have a low detection rate at the prostate-specific antigen (PSA) levels at which targeted salvage therapy is effective. 11 C-choline and 18 F-fluoromethylcholine, though widely used, have poor sensitivity at low PSA levels. 68 Ga-PSMA (Glu-NH-CO-NH-Lys-(Ahx)-[ 68 Ga- N,N ′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine- N,N ′-diacetic acid]) has shown promising results in retrospective trials. Our aim was to prospectively ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2015 - Society of Nuclear Medicine and Molecular Imaging | Journal of Nuclear Medicine
Thomas L. Parchman, Pim Edelaar, Kathryn A. Uckele, Eduardo T. Mezquida, Daniel Alonso, Joshua P. Jahner, Ron W. Summers, Craig W. Benkman,
While many conifers produce annually variable seed crops, serotinous species (which hold seeds in cones for multiple years) represent unusually stable food resources for seed predators. Such stability is conducive to residency and potentially population divergence of consumers as exemplified by the Cassia crossbill (Loxia sinesciuris) in North America. We used genotyping by sequencing (GBS) to test whether three Mediterranean subspecies of common crossbills (L. curvirostra) associated with the serotinous ...
Tópico(s): Forest Insect Ecology and Management
2018 - Oxford University Press | Journal of Evolutionary Biology
Eric M. Thompson, Thomas Hielscher, Éric Bouffet, Marc Remke, Betty Luu, Sridharan Gururangan, Roger E. McLendon, Darell D. Bigner, Eric Lipp, Sébastien Perreault, Yoon-Jae Cho, Gerald A. Grant, Seung-Ki Kim, Ji Yeoun Lee, Amulya A. Nageswara Rao, Caterina Giannini, Kay Ka Wai Li, Ho‐Keung Ng, Yu Yao, Toshihiro Kumabe, Teiji Tominaga, Wiesława Grajkowska, Marta Perek‐Polnik, David C.Y. Low, Wan Tew Seow, Kenneth Tou En Chang, Jaume Mora, Ian F. Pollack, Ronald L. Hamilton, Sarah Leary, Andrew S. Moore, Wendy J. Ingram, Andrew R. Hallahan, Anne Jouvet, Michelle Fèvre‐Montange, Alexandre Vasiljevic, Cécile Faure‐Conter, Tomoko Shofuda, Naoki Kagawa, Naoya Hashimoto, Nada Jabado, Alexander G. Weil, Tenzin Gayden, Takafumi Wataya, Tarek Shalaby, Michael Grotzer, Karel Zitterbart, Jaroslav Štěrba, Leoš Křen, Tibor Hortobágyi, Álmos Klekner, László Bognár, Tímea Pócza, Péter Hauser, Ulrich Schüller, Shin Jung, Woo-Youl Jang, Pim J. French, Johan M. Kros, Marie‐Lise C. van Veelen, Luca Massimi, Jeffrey R. Leonard, Joshua B. Rubin, Rajeev Vibhakar, Lola B. Chambless, Michael K. Cooper, Reid C. Thompson, Cláudia C. Faria, Alice Carvalho, Sofia Nunes, José Pimentel, Xing Fan, Karin M. Muraszko, Enrique López‐Aguilar, David Lyden, Livia Garzia, David Shih, Noriyuki Kijima, Christian Schneider, Jennifer Adamski, Paul A. Northcott, Marcel Kool, David Jones, Jennifer A. Chan, Ana Nikolić, Maria Luisa Garrè, Erwin G. Van Meir, Satoru Osuka, Jeffrey J. Olson, Arman Jahangiri, Brandyn Castro, Nalin Gupta, William A. Weiss, Iska Moxon‐Emre, Donald Mabbott, Álvaro Lassaletta, Cynthia Hawkins, Uri Tabori, James M. Drake, Abhaya V. Kulkarni, Peter B. Dirks, James T. Rutka, Andrey Korshunov, Stefan M. Pfister, Roger J. Packer, Vijay Ramaswamy, Michael D. Taylor,
Background Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner. Methods We retrospectively ...
Tópico(s): Hedgehog Signaling Pathway Studies
2016 - Elsevier BV | The Lancet Oncology
Produção Nacional
Revisado por pares
Hallie Coltin, Lakshmikirupa Sundaresan, Kyle Smith, Patryk Skowron, Luca Massimi, Charles G. Eberhart, Karisa C. Schreck, Nalin Gupta, William A. Weiss, Daniela Pretti da Cunha Tirapelli, Carlos Gilberto Carlotti, Kay K. W. Li, Marina Ryzhova, Andrey Golanov, Olga Zheludkova, O V Absalyamova, Konstantin Okonechnikov, Damian Stichel, Andreas von Deimling, Caterina Giannini, Scott Raskin, Erwin G. Van Meir, Jennifer A. Chan, Daniel W. Fults, Lola B. Chambless, Seung-Ki Kim, Alexandre Vasiljevic, Cécile Faure‐Conter, Rajeev Vibhakar, Shin Jung, Sarah Leary, Jaume Mora, Roger E. McLendon, Ian F. Pollack, Péter Hauser, Wiesława Grajkowska, Joshua B. Rubin, Marie‐Lise C. van Veelen, Pim J. French, Johan M. Kros, Linda M. Liau, Stefan M. Pfister, Marcel Kool, Noriyuki Kijima, Michael D. Taylor, Roger J. Packer, Paul A. Northcott, Andrey Korshunov, Vijay Ramaswamy,
Medulloblastoma, a common pediatric malignant central nervous system tumour, represent a small proportion of brain tumours in adults. Previously it has been shown that in adults, Sonic Hedgehog (SHH)-activated tumours predominate, with Wingless-type (WNT) and Group 4 being less common, but molecular risk stratification remains a challenge. We performed an integrated analysis consisting of genome-wide methylation profiling, copy number profiling, somatic nucleotide variants and correlation of clinical ...
Tópico(s): Chromatin Remodeling and Cancer
2021 - Springer Science+Business Media | Acta Neuropathologica
Alexandra Duverger, Frank Wolschendorf, Joshua C. Anderson, Frederic H. Wagner, Alberto Bosque, Takao Shishido, Jennifer Jones, Vicente Planelles, Christopher D. Willey, Randy Q. Cron, Olaf Kutsch,
Despite the clinical relevance of latent HIV-1 infection as a block to HIV-1 eradication, the molecular biology of HIV-1 latency remains incompletely understood. We recently demonstrated the presence of a gatekeeper kinase function that controls latent HIV-1 infection. Using kinase array analysis, we here expand on this finding and demonstrate that the kinase activity profile of latently HIV-1-infected T cells is altered relative to that of uninfected T cells. A ranking of altered kinases generated ...
Tópico(s): HIV/AIDS drug development and treatment
2013 - American Society for Microbiology | Journal of Virology
Bradley D. Allen, Pim van Ooij, Alex J. Barker, Maria Carr, Maya Gabbour, Susanne Schnell, Kelly Jarvis, James Carr, Michael Markl, Cynthia K. Rigsby, Joshua D. Robinson,
Background To evaluate the 3D hemodynamics in the thoracic aorta of pediatric and young adult bicuspid aortic valve (BAV) patients. Methods 4D flow MRI was performed in 30 pediatric and young adult BAV patients (age: 13.9 ± 4.4 (range: [3.4, 20.7]) years old, M:F = 17:13) as part of this Institutional Review Board‐approved study. Nomogram‐based aortic root Z‐scores were calculated to assess aortic dilatation and degree of aortic stenosis (AS) severity was assessed on MRI. Data analysis included calculation ...
Tópico(s): Congenital Heart Disease Studies
2015 - Wiley | Journal of Magnetic Resonance Imaging
Produção Nacional
Revisado por pares
Liana Nobre, Michal Zápotocký, Sara Khan, Kohei Fukuoka, Adriana Fonseca, Tara McKeown, David Sumerauer, Aleš Vícha, Wiesława Grajkowska, Joanna Trubicka, Kay Ka Wai Li, Ho‐Keung Ng, Luca Massimi, Ji Yeoun Lee, Seung-Ki Kim, Shayna Zelcer, Alexandre Vasiljevic, Cécile Faure‐Conter, Péter Hauser, Bolesław Lach, Marie‐Lise C. van Veelen, Pim J. French, Erwin G. Van Meir, William A. Weiss, Nalin Gupta, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, Joshua B. Rubin, Andrew S. Moore, Lola B. Chambless, Rajeev Vibhakar, Young Seob Shin, Maura Massimino, Roger E. McLendon, Helen Wheeler, Massimo Zollo, Veronica Ferruci, Toshihiro Kumabe, Cláudia C. Faria, Jaroslav Štěrba, Shin Jung, Enrique López‐Aguilar, Jaume Mora, Carlos Gilberto Carlotti, James M. Olson, Sarah Leary, Jason E. Cain, Lenka Krsková, Josef Zámečnı́k, Cynthia Hawkins, Uri Tabori, Annie Huang, Ute Bartels, Paul A. Northcott, Michael D. Taylor, Stephen Yip, Jordan R. Hansford, Éric Bouffet, Vijay Ramaswamy,
Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763–0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong ...
Tópico(s): Brain Metastases and Treatment
2020 - Elsevier BV | Cell Reports Medicine
Ali Sekizkardes, Samir Budhathoki, Lingxiang Zhu, Victor Kusuma, Zi Tong, Joshua S. McNally, Janice A. Steckel, Shouliang Yi, David Hopkinson,
New polymeric blend membranes for CO2 separation were synthesized based on insights from molecular dynamics simulation. A molecular-level structure-property relationship in polymers of intrinsic microporosity (PIM) based blend membranes was investigated in detail computationally. Calculated local density profiles and energy of interaction of the blend membranes, composed of PIM-1 and various polyphosphazenes, showed that using the polyphosphazene with a higher concentration of ether side chains can ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2021 - Elsevier BV | Journal of Membrane Science
Ayush Giri, Jacklyn N. Hellwege, Jacob M. Keaton, Jihwan Park, Chengxiang Qiu, Helen Warren, Eric S. Torstenson, Csaba P. Kövesdy, Yan V. Sun, Otis D. Wilson, Cassianne Robinson‐Cohen, Christianne L. Roumie, Cecilia P. Chung, Kelly A. Birdwell, Scott M. Damrauer, Scott L. DuVall, Derek Klarin, Kelly Cho, Yu Wang, Εvangelos Εvangelou, Claudia P. Cabrera, Louise V. Wain, Rojesh Shrestha, Brian S. Mautz, Elvis A. Akwo, Muralidharan Sargurupremraj, Stéphanie Debette, Michael Boehnke, Laura J. Scott, Jian’an Luan, Jing-Hua Zhao, Sara M. Willems, Sébastien Thériault, Nabi Shah, Christopher Oldmeadow, Peter Almgren, Ruifang Li‐Gao, Niek Verweij, Thibaud Boutin, Massimo Mangino, Ioanna Ntalla, Elena V. Feofanova, Praveen Surendran, James P. Cook, Savita Karthikeyan, Najim Lahrouchi, Chunyu Liu, Nuno Sepúlveda, Tom G. Richardson, Aldi T. Kraja, Philippe Amouyel, Martin Farrall, Neil R Poulter, Markku Laakso, Eleftheria Zeggini, Peter Sever, Robert A. Scott, Claudia Langenberg, Nicholas J. Wareham, David Conen, Nicholette D. Palmer, John Attia, Daniel I. Chasman, Paul M. Ridker, Olle Melander, Dennis Owen Mook-Kanamori, Pim van der Harst, Francesco Cucca, David Schlessinger, Caroline Hayward, Tim D. Spector, Marjo-Riitta Jarvelin, Branwen J. Hennig, Nicholas J. Timpson, Wei-Qi Wei, Joshua C. Smith, Yaomin Xu, Michael E. Matheny, Edward D. Siew, Cecilia M. Lindgren, Karl‐Heinz Herzig, George Dedoussis, Joshua C. Denny, Bruce M. Psaty, Joanna M. M. Howson, Patricia B. Munroe, Christopher Newton‐Cheh, Mark J. Caulfield, Paul Elliott, J. Michael Gaziano, John Concato, Peter W.F. Wilson, Philip S. Tsao, Digna R. Velez Edwards, Katalin Suszták, Christopher J. O’Donnell, Adriana M. Hung, Todd L. Edwards,
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome- ...
Tópico(s): Hormonal Regulation and Hypertension
2018 - Nature Portfolio | Nature Genetics
Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Elke Pfaff, David Shih, Dianna C. Martin, Pedro Castelo‐Branco, Berivan Baskin, Peter N. Ray, Éric Bouffet, André O. von Bueren, David Jones, Paul A. Northcott, Marcel Kool, Dominik Sturm, Trevor J. Pugh, Scott L. Pomeroy, Yoon-Jae Cho, Torsten Pietsch, Marco Gessi, Stefan Rutkowski, László Bognár, Álmos Klekner, Byung-Kyu Cho, Seung-Ki Kim, Kyu‐Chang Wang, Charles G. Eberhart, Michelle Fèvre‐Montange, Maryam Fouladi, Pim J. French, Max Kros, Wiesława Grajkowska, Nalin Gupta, William A. Weiss, Péter Hauser, Nada Jabado, Anne Jouvet, Shin Jung, Toshihiro Kumabe, Bolesław Lach, Jeffrey R. Leonard, Joshua B. Rubin, Linda M. Liau, Luca Massimi, Ian F. Pollack, Young Seob Shin, Erwin G. Van Meir, Karel Zitterbart, Ulrich Schüller, Rebecca M. Hill, Janet C. Lindsey, Ed C. Schwalbe, Simon Bailey, David W. Ellison, Cynthia Hawkins, David Malkin, Steven C. Clifford, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor, Uri Tabori,
Purpose Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles. Patients and Methods We determined subgroup affiliation, TP53 mutation status, and clinical outcome in a discovery cohort of 397 medulloblastomas. We subsequently validated our results on an independent cohort of 156 medulloblastomas. Results TP53 mutations are enriched in wingless (WNT; 16%) and sonic hedgehog ( ...
Tópico(s): Chromatin Remodeling and Cancer
2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Louise Emmett, Pim J. van Leeuwen, Rohan Nandurkar, Matthijs J. Scheltema, Thomas W. Cusick, George Hruby, Andrew Kneebone, Thomas Eade, Gerald Fogarty, Raj Jagavkar, Quoc Nguyen, Bao Ho, Anthony M. Joshua, Phillip D. Stricker,
68 Ga-PSMA (prostate-specific membrane antigen) PET/CT is increasingly used in men with prostate-specific antigen (PSA) failure after radical prostatectomy (RP) to triage those who will benefit from salvage radiation treatment (SRT). This study examines the value of PSMA-informed SRT in improving treatment outcomes in the context of biochemical failure after RP. Methods: We analyzed men with rising PSA after RP with PSA readings between 0.05 and 1.0 ng/mL, considered eligible for SRT at the time of PSMA. ...
Tópico(s): Urologic and reproductive health conditions
2017 - Society of Nuclear Medicine and Molecular Imaging | Journal of Nuclear Medicine
Produção Nacional
Revisado por pares
Florence M.G. Cavalli, Marc Remke, Ladislav Rampášek, John Peacock, David Shih, Betty Luu, Livia Garzia, Jonathon Torchia, Carolina Nör, A. Sorana Morrissy, Sameer Agnihotri, Yuan Thompson, Claudia M. Kuzan-Fischer, Hamza Farooq, Keren Isaev, Craig Daniels, Byung-Kyu Cho, Seung-Ki Kim, Kyu‐Chang Wang, Ji Yeoun Lee, Wiesława Grajkowska, Marta Perek‐Polnik, Alexandre Vasiljevic, Cécile Faure‐Conter, Anne Jouvet, Caterina Giannini, Amulya A. Nageswara Rao, Kay Ka Wai Li, Ho‐Keung Ng, Charles G. Eberhart, Ian F. Pollack, Ronald L. Hamilton, G. Yancey Gillespie, James M. Olson, Sarah Leary, William A. Weiss, Bolesław Lach, Lola B. Chambless, Reid C. Thompson, Michael K. Cooper, Rajeev Vibhakar, Péter Hauser, Marie‐Lise C. van Veelen, Johan M. Kros, Pim J. French, Young Seob Shin, Toshihiro Kumabe, Enrique López‐Aguilar, Karel Zitterbart, Jaroslav Štěrba, Gaetano Finocchiaro, Maura Massimino, Erwin G. Van Meir, Satoru Osuka, Tomoko Shofuda, Álmos Klekner, Massimo Zollo, Jeffrey R. Leonard, Joshua B. Rubin, Nada Jabado, Steffen Albrecht, Jaume Mora, Timothy Van Meter, Shin Jung, Andrew S. Moore, Andrew R. Hallahan, Jennifer A. Chan, Daniela Pretti da Cunha Tirapelli, Carlos Gilberto Carlotti, Maryam Fouladi, José Pimentel, Cláudia C. Faria, Ali G. Saad, Luca Massimi, Linda M. Liau, Helen Wheeler, Hideo Nakamura, Samer K. Elbabaa, Mario Pérezpeña-Díazconti, Fernando Chico Ponce de León, Shenandoah Robinson, Michal Zápotocký, Álvaro Lassaletta, Annie Huang, Cynthia Hawkins, Uri Tabori, Éric Bouffet, Ute Bartels, Peter B. Dirks, James T. Rutka, Gary D. Bader, Jüri Reimand, Anna Goldenberg, Vijay Ramaswamy, Michael D. Taylor,
While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of ...
Tópico(s): Cancer Genomics and Diagnostics
2017 - Cell Press | Cancer Cell
Hiromichi Suzuki, Sachin Kumar, Shimin Shuai, Ander Díaz‐Navarro, Ana Gutiérrez‐Fernández, Pasqualino de Antonellis, Florence M.G. Cavalli, Kyle Juraschka, Hamza Farooq, Ichiyo Shibahara, Maria C. Vladoiu, Jiao Zhang, Namal Abeysundara, David Przelicki, Patryk Skowron, Nicole Gauer, Betty Luu, Craig Daniels, Xiaochong Wu, Antoine Forget, Ali Momin, Jun Wang, Weifan Dong, Seung-Ki Kim, Wiesława Grajkowska, Anne Jouvet, Michelle Fèvre‐Montange, Maria Luisa Garrè, Amulya A. Nageswara Rao, Caterina Giannini, Johan M. Kros, Pim J. French, Nada Jabado, Ho‐Keung Ng, Wai Sang Poon, Charles G. Eberhart, Ian F. Pollack, James M. Olson, William A. Weiss, Toshihiro Kumabe, Enrique López‐Aguilar, Bolesław Lach, Maura Massimino, Erwin G. Van Meir, Joshua B. Rubin, Rajeev Vibhakar, Lola B. Chambless, Noriyuki Kijima, Álmos Klekner, László Bognár, Jennifer A. Chan, Cláudia C. Faria, Jiannis Ragoussis, Stefan M. Pfister, Anna Goldenberg, Robert J. Wechsler‐Reya, Swneke D. Bailey, Livia Garzia, A. Sorana Morrissy, Marco A. Marra, Xi Huang, David Malkin, Olivier Ayrault, Vijay Ramaswamy, Xosé S. Puente, John A. Calarco, Lincoln Stein, Michael D. Taylor,
In cancer, recurrent somatic single-nucleotide variants—which are rare in most paediatric cancers—are confined largely to protein-coding genes1–3. Here we report highly recurrent hotspot mutations (r.3A>G) of U1 spliceosomal small nuclear RNAs (snRNAs) in about 50% of Sonic hedgehog (SHH) medulloblastomas. These mutations were not present across other subgroups of medulloblastoma, and we identified these hotspot mutations in U1 snRNA in only G mutations are identified in U1 splicesomal small nuclear ...
Tópico(s): Renal and related cancers
2019 - Nature Portfolio | Nature
Joseph A. Turner, Dominic A. Andradi‐Brown, Andrea Gori, Pim Bongaerts, Heidi L. Burdett, Christine Ferrier‐Pagès, Christian R. Voolstra, David K. Weinstein, Tom C. L. Bridge, Federica Costantini, Erika Gress, Jack H. Laverick, Yossi Loya, Gretchen Goodbody‐Gringley, Sergio Rossi, Michelle L. Taylor, Núria Viladrich, Joshua D. Voss, Joel Williams, Lucy C. Woodall, Gal Eyal,
Mesophotic coral ecosystems (MCEs) and temperate mesophotic ecosystems (TMEs) have received increasing research attention during the last decade as many new and improved methods and technologies have become more accessible to explore deeper parts of the ocean. However, large voids in knowledge remain in our scientific understanding, limiting our ability to make scientifically based decisions for conservation and management of these ecosystems. Here, we present a list of key research and conservation ...
Tópico(s): Marine and fisheries research
2019 - Springer International Publishing | Coral reefs of the world
Produção Nacional
Revisado por pares
Ιωάννα Ντάλλα, Lu‐Chen Weng, James Cartwright, Amelia Weber Hall, Garðar Sveinbjörnsson, Nathan R. Tucker, Seung Hoan Choi, Mark Chaffin, Carolina Roselli, Michael R. Barnes, Borbála Mifsud, Helen Warren, Caroline Hayward, Jonathan Marten, James Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolčić, Ozren Polašek, Igor Rudan, Nathalia Matta Araujo, Maria Fernanda Lima‐Costa, Antônio Luiz Pinho Ribeiro, Renan P. Souza, Eduardo Tarazona‐Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P. Morris, Fabiola Del Greco M, Luisa Foco, Martin Gögele, Andrew A. Hicks, James P. Cook, Lars Lind, Cecilia M. Lindgren, Johan Sundström, Christopher P. Nelson, Muhammad Riaz, Nilesh J. Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P. Mishra, Nina Mononen, Kjell Nikus, Mark J. Caulfield, Anna F. Dominiczak, Sandosh Padmanabhan, May E. Montasser, Jeff O’Connell, Kathleen A. Ryan, Alan R. Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri‐Kähönen, Terho Lehtimäki, Leo‐Pekka Lyytikäinen, Olli T. Raitakari, Catriona L. K. Barnes, Harry Campbell, Peter K. Joshi, James F. Wilson, Aaron Isaacs, Jan A. Kors, Cornelia M. van Duijn, Paul L. Huang, Vilmundur Guðnason, Tamara B. Harris, Lenore J. Launer, Albert V. Smith, Erwin P. Böttinger, Ruth J. F. Loos, Girish N. Nadkarni, Michael Preuß, Adolfo Correa, Hao Mei, James G. Wilson, Thomas Meitinger, Martina Müller‐Nurasyid, Annette Peters, Mélanie Waldenberger, Massimo Mangino, Timothy D. Spector, Michiel Rienstra, Yordi J. van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F. Sinner, Konstantin Strauch, Michael J. Cutler, Diane Fatkin, Barry London, Morten S. Olesen, Dan M. Roden, M. Benjamin Shoemaker, J. G. Smith, Mary L. Biggs, Joshua C. Bis, Jennifer A. Brody, Bruce M. Psaty, Kenneth Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P. Pramstaller, Ian Ford, J. Wouter Jukema, Peter W. Macfarlane, Stella Trompet, Marcus Dörr, Stephan B. Felix, Uwe Völker, Stefan Weiß, Aki S. Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R. Heckbert, Henry J. Lin, Jerome I. Rotter, Kent D. Taylor, Jie Yao, Renée de Mutsert, Arie C. Maan, Dennis O. Mook‐Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G. Lakatta, Yong Qian, Kirill V. Tarasov, Daniel Levy, Honghuang Lin, Christopher Newton‐Cheh, Kathryn L. Lunetta, Alison D. Murray, David J. Porteous, Blair H. Smith, Bruno H. Stricker, André G. Uitterlinden, Marten E. van den Berg, Jeffrey Haessler, Rebecca D. Jackson, Charles Kooperberg, Ulrike Peters, Alexander P. Reiner, Eric A. Whitsel, Álvaro Alonso, Dan E. Arking, Eric Boerwinkle, Georg Ehret, Elsayed Z. Soliman, Christy L. Avery, Stephanie M. Gogarten, Kathleen F. Kerr, Cathy C. Laurie, Amanda A. Seyerle, Adrienne M. Stilp, Solmaz Assa, M. Abdullah Said, M. Yldau van der Ende, Pier D. Lambiase, Michele Orini, Julia Ramírez, Stefan van Duijvenboden, Davíð O. Arnar, Daníel F. Guðbjartsson, Hilma Hólm, Patrick Sulem, Guðmar Þorleifsson, Rósa B. Þórólfsdóttir, Unnur Þorsteinsdóttir, Emelia J. Benjamin, Andrew Tinker, Kári Stéfansson, Patrick T. Ellinor, Yalda Jamshidi, Steven A. Lubitz, Patricia B. Munroe,
Abstract The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry ( N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2020 - Nature Portfolio | Nature Communications
Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Dianna C. Martin, Pedro Castelo‐Branco, Cindy H. Zhang, Michael Fraser, Ken Tse, Raymond Poon, David Shih, Berivan Baskin, Peter N. Ray, Éric Bouffet, Peter B. Dirks, André O. von Bueren, Elke Pfaff, Andrey Korshunov, David Jones, Paul A. Northcott, Marcel Kool, Trevor J. Pugh, Scott L. Pomeroy, Yoon-Jae Cho, Torsten Pietsch, Marco Gessi, Stefan Rutkowski, László Bognár, Byung-Kyu Cho, Charles G. Eberhart, Cécile Faure‐Conter, Maryam Fouladi, Pim J. French, Wiesława Grajkowska, Nalin Gupta, Péter Hauser, Nada Jabado, Alexandre Vasiljevic, Shin Jung, Seung-Ki Kim, Álmos Klekner, Toshihiro Kumabe, Bolesław Lach, Jeffrey R. Leonard, Linda M. Liau, Luca Massimi, Ian F. Pollack, Young Shin, Joshua B. Rubin, Erwin G. Van Meir, Kyu‐Chang Wang, William A. Weiss, Karel Zitterbart, Robert G. Bristow, Benjamin A. Alman, Cynthia Hawkins, David Malkin, Steven C. Clifford, Stefan M. Pfister, Michael D. Taylor, Uri Tabori,
TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2014 - Springer Science+Business Media | Acta Neuropathologica Communications
Produção Nacional
Revisado por pares
Patryk Skowron, Hamza Farooq, Florence M.G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana Guerreiro Stücklin, Maria C. Vladoiu, Vernon Fong, Borja Holgado, Carolina Nör, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raúl A. Suárez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiaoyun Zhang, Craig Daniels, Peter B. Dirks, David Malkin, Éric Bouffet, Uri Tabori, James Loukides, François Doz, Franck Bourdeaut, Olivier Delattre, Julien Masliah‐Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wiesława Grajkowska, Carlos Gilberto Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Bolesław Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Álmos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Péter Hauser, Kay Ka Wai Li, Ho‐Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Seob Shin, Maria Luisa Garrè, Ulrich Schüller, Tomoko Shofuda, Cláudia C. Faria, Enrique López‐Aguilar, Gelareh Zadeh, Chi‐chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J.M. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor,
Abstract Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the cAMP dependent pathway ( GNAS , PRKAR1A ) which converge on GLI2 activity and show ...
Tópico(s): Genomics and Chromatin Dynamics
2021 - Nature Portfolio | Nature Communications