Pedro Núñez-Cacho Utrilla, Juan Carlos Leyva‐Díaz, Jorge Sánchez-Molina, Rody Van der Gun,
Every day, society's concern over pollution caused by plastic waste grows greater. One of the most intensive sectors for the use of plastic is the food industry. Companies in this sector face the challenge of transitioning to a more sustainable and less intensive model of plastic use, respecting the principles established for a circular economy. Accordingly, one of the questions that industries tend to ask is whether sustainability will influence the consumer's purchase decision. To respond to this, ...
Tópico(s): Sustainable Supply Chain Management
2020 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Jaime Madrigal Pulido, Israel Enrique Padilla Guerrero, Isaura de J. Magaña Martínez, Briseida Cacho Valadez, Juan Carlos Torres Guzmán, Eduardo Salazar Solís, J. Felix Gutíerrez Corona, Augusto Schrank, Juan Francisco Jiménez-Bremont, Angélica González Hernandez,
The gene ODC1, which codes for the ornithine decarboxylase enzyme, was isolated from the entomopathogenic fungus, Metarhizium anisopliae. The deduced amino acid sequence predicted a protein of 447 amino acids with a molecular weight of 49.3 kDa that contained the canonical motifs of ornithine decarboxylases. The ODC1 cDNA sequence was expressed in Escherichia coli cells; radiometric enzyme assays showed that the purified recombinant protein had ornithine decarboxylase activity. The optimum pH of ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2011 - Elsevier BV | Microbiological Research
Cristina Nerı́n, Jesús Salafranca, Juan Cacho, Carlos Rubio-Terrés,
A procedure consisting of connecting in series two different HPLC columns, one for size-exclusion chromatography (SEC) and the second one a normal-phase (silica) column has been developed. An automatic three-way switching valve was placed between the two columns. Through the valve, the polymer was drained whereas the rest of the compounds, a group of antioxidants and UV stabilizers, were separated and analyzed in the second column. The behaviour of the SEC column in different organic phases is studied. ...
Tópico(s): Chromatography in Natural Products
1995 - Elsevier BV | Journal of Chromatography A
Juan Cacho, Liliana Moncayo, Juan Carlos Palma, Vicente Ferreira, Laura Culleré,
Pisco is a common beverage, originating in some South American countries (such as Peru and Chile), which is obtained by distillation of wine made from different varieties of grapes. In this paper, thirty one commercial Peruvian pisco samples made with Negra Criolla, Mollar and Uvina grapes have been analyzed by gas chromatography–flame ionization (GC–FID) and mass spectrometry detection (GC–MS). A representative sample of each variety was also evaluated by gas chromatography–olfactometry (GC–O). A sensory ...
Tópico(s): Phytochemicals and Antioxidant Activities
2013 - Elsevier BV | Food Research International
Juan Cacho, Liliana Moncayo, Juan Carlos Palma, Vicente Ferreira, Laura Culleré,
ABSTRACT Forty‐five samples of commercial pisco made with Albilla, Muscat and Torontel grapes in different areas of Peru have been evaluated by gas chromatography–olfactometry (GC‐O) and chemical quantitative analysis. The GC‐O study revealed that the Peruvian pisco made of these varieties of grapes has an aroma profile formed by nearly 30 odorants. The odorant 2,3‐pentanedione was detected only in the Albilla sample, producing significant differences. The chemical analysis of the volatiles of these ...
Tópico(s): Plant biochemistry and biosynthesis
2013 - Wiley | Flavour and Fragrance Journal
Juan Cacho, Liliana Moncayo, Juan Carlos Palma, Vicente Ferreira, Laura Culleré,
Thirty-three commercial pisco samples made with Italia grapes in five different regions in Perú have been evaluated by gas chromatography-olfactometry (GC-O) and chemical quantitative analysis for the first time. The GC-O study has revealed that the Peruvian pisco made from this aromatic variety of grape (Italia) has an aroma profile composed of twenty-five odorants. Only one of them could not be identified (LRIDB-WAX 2313). Most of the odorants are fermentation-related, while guaiacol, β-damascenone, ...
Tópico(s): Plant biochemistry and biosynthesis
2012 - Elsevier BV | Food Research International
Carlos García-Fajardo Palacios, Alberto Cacho Casado, Abelardo Fonte Trigo, Juan Carlos Pérez Varela,
Resumen: Fundamento.La relación intrínseca entre alteración oclusal y trastorno articular no es un paradigma que se cumpla siempre.Sin embargo, el análisis oclusal debe ser siempre un requisito imprescindible en la exploración del paciente disfuncional ya que multitud de estudios demuestran que puede representar un factor etiológico de primer orden.Material y método.A través de distintas revisiones bibliográficas se describen los principales estados oclusales y se intenta establecer una posible ...
Tópico(s): Oropharyngeal Anatomy and Pathologies
2007 - SciELO | RCOE
Agustı́n Albillos, Juan Carlos García–Pagán, Jerónimo Iborra, Juan Carlos Bandi, Guillermo Cacho, María Pérez-Páramo, Àngels Escorsell, José Luís Calleja, P Escartín, Jaime Bosch,
Abstract Background & Aims: The association of prazosin to propranolol enhances the decrease in portal pressure but may cause hypotension and sodium retention. The aim of this study was to compare the portal pressure reduction and safety of the combination of propranolol plus prazosin with that of propranolol plus isosorbide-5-mononitrate (ISMN). Methods: Fifty-six portal-hypertensive cirrhotics received randomly propranolol plus prazosin (n = 28) or propranolol plus ISMN (n = 28) orally for 3 months. Hemodynamics ...
Tópico(s): Renal function and acid-base balance
1998 - Elsevier BV | Gastroenterology
Cristina Nerı́n, Carlos Rubio-Terrés, Juan Cacho, Jesús Salafranca,
Headspace sampling methods prior to capillary gas chromatography have been widely used for the determination of volatile compounds present in very different kinds of samples. This paper describes an automated and rapid system to determine volatiles from yoghurt. Thirty‐five volatile organic compounds (VOCs) were identified in polystyrene cups used for yoghurt packaging and 42 VOCs from yoghurt samples. Quantitation of styrene in several samples from the Spanish retail market was carried out.
Tópico(s): Meat and Animal Product Quality
1998 - Taylor & Francis | Food Additives & Contaminants
Cristina Nerı́n, Jesús Salafranca, Carlos Rubio-Terrés, Juan Cacho,
Two multicomponent post-use recycled plastics named as NPP40A3 (formulated with 85% HDPE and 15% of a PP-PS-PVC mixture) and NPP40A6 (formulated with 80% NPP40A3, 10% ABS and 10% HIPS), both of them with 3.1% of plasticizer and 0.6% of stabilizer to obtain a better final product, have been analysed. Plastics were extracted both with dichloromethane and methylbenzene, and analysed by HPLC and GC-MS to identify the maximum possible number of compounds. Major additives quantified were di(ethylhexyl)phthalate ( ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
1998 - Taylor & Francis | Food Additives & Contaminants
Juan Cacho, Laura Culleré, Liliana Moncayo, Juan Carlos Palma, Vicente Ferreira,
ABSTRACT Twenty‐one commercial pisco samples made with Quebranta grapes from four different geographical areas in Peru have been evaluated by gas chromatography–olfactometry (GC‐O) and chemical quantitative analysis. The GC‐O study revealed that the Peruvian pisco from the Quebranta grape variety has a relatively simple aroma profile formed by 22 odorants, all of which could be identified. Most of the odorants are fermentation related, while guaiacol, β ‐damascenone, geraniol and linalool come from ...
Tópico(s): Phytochemicals and Antioxidant Activities
2012 - Wiley | Flavour and Fragrance Journal
Sergio Iván Valdés‐Ferrer, José C. Crispín, Pablo F. Belaunzarán-Zamudio, Carlos A. Rodríguez-Osorio, Bernardo Cacho‐Díaz, Jorge Alcocer‐Varela, Carlos Cantú‐Brito, Juan Sierra‐Madero,
In human immunodeficiency virus (HIV)-infection, persistent T-cell activation leads to rapid turnover and increased cell death, leading to immune exhaustion and increased susceptibility to opportunistic infections. Stimulation of the vagus nerve increases acetylcholine (ACh) release and modulates inflammation in chronic inflammatory conditions, a neural mechanism known as the cholinergic anti-inflammatory pathway (CAP). Pyridostigmine (PDG), an ACh-esterase inhibitor, increases the half-life of endogenous ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2017 - Frontiers Media | Frontiers in Immunology
Briseida Cacho‐Valadez, Fernando Muñoz-Lobato, José Rafael Pedrajas, Juan Cabello, Juan Carlos Fierro-González, Plácido Navas, Peter Swoboda, Chris D. Link, Antonio Miranda‐Vizuete,
Functional in vivo studies on the mitochondrial thioredoxin system are hampered by the embryonic or larval lethal phenotypes displayed by murine or Drosophila knock-out models. Thus, the access to alternative metazoan knock-out models for the mitochondrial thioredoxin system is of critical importance.We report here the characterization of the mitochondrial thioredoxin system of Caenorhabditis elegans that is composed of the genes trx-2 and trxr-2. We demonstrate that the proteins thioredoxin 2 (TRX- ...
Tópico(s): Mitochondrial Function and Pathology
2012 - Mary Ann Liebert, Inc. | Antioxidants and Redox Signaling
Ana Moreno, Ana Satorre Pérez, Jaime Frigola, Vanesa Nieto-Moreno, Marta Rodrigo‐Gámiz, Belén Martrat, Penélope González‐Sampériz, Mario Morellón, Celia Martín‐Puertas, Juan Pablo Corella, Ãnchel Belmonte, Carlos Sancho, Isabel Cacho, Gemma Herrera, Miquel Canals, Joan O. Grimalt, F.J. Jiménez-Espejo, Francisca Martı́nez-Ruiz, Teresa Vegas‐Vilarrúbia, Blas L. Valero‐Garcés,
Selected multi-proxy and accurately dated marine and terrestrial records covering the past 2000 years in the Iberian Peninsula (IP) facilitated a comprehensive regional paleoclimate reconstruction for the Medieval Climate Anomaly (MCA: 900–1300 AD). The sequences enabled an integrated approach to land–sea comparisons and, despite local differences and some minor chronological inconsistencies, presented clear evidence that the MCA was a dry period in the Mediterranean IP. It was a period characterized ...
Tópico(s): Archaeology and ancient environmental studies
2012 - Elsevier BV | Quaternary Science Reviews
Cristina Nerı́n, Carlos Rubio-Terrés, Juan Cacho, Jesús Salafranca,
Tópico(s): Spectroscopy and Chemometric Analyses
1995 - Springer Science+Business Media | Chromatographia
Abhinav Talwar, Jeffrey Varghese, Gabriel Knight, Nitin Katariya, Juan‐Carlos Caicedo, Zachary C. Dietch, Daniel Borja–Cacho, Daniela P. Ladner, Derrick A. Christopher, Talia Baker, Michaël Abécassis, S. Mouli, Kush Desai, Ahsun Riaz, Bart Thornburg, Riad Salem,
Abstract High‐grade portal vein thrombosis (PVT) is often considered to be a technically challenging scenario for liver transplantation (LT) and in some centers a relative contraindication. This study compares patients with chronic obliterative PVT who underwent portal vein recanalization–transjugular intrahepatic portosystemic shunt (PVR‐TIPS) and subsequent LT to those with partial nonocclusive PVT who underwent LT without an intervention. This institutional review board‐approved study analyzed 49 ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2022 - Lippincott Williams & Wilkins | Hepatology Communications
Rodrigo Jover, Pedro Zapater, Eduardo Polanía, Luís Bujanda, Ángel Lanas, José Antonio Hermo, Joaquín Cubiella, Akiko Ono, Yanira González‐Méndez, Antonio Peris, María Pellisé, Agustín Seoane, Alberto Herreros de Tejada, Marta Ponce, José Carlos Marín-Gabriel, María Chaparro, Guillermo Cacho, Servando Fernández-Díez, Juan Arenas, Federico Sopeña, Luisa de–Castro, Pablo Vega, María Rodríguez‐Soler, Fernando Carballo, María Sala, Juan Diego Morillas, Montserrat Andreu, Enrique Quintero, Antoni Castells,
Background Adenoma detection rate (ADR) has become the most important quality indicator for colonoscopy. Objective The aim of this study was to investigate which modifiable factors, directly related to the endoscopic procedure, influenced the ADR in screening colonoscopies. Design Observational, nested study. Setting Multicenter, randomized, controlled trials. Patients Asymptomatic people aged 50 to 69 years were eligible for a multicenter, randomized, controlled trial designed to compare colonoscopy ...
Tópico(s): Gallbladder and Bile Duct Disorders
2012 - Elsevier BV | Gastrointestinal Endoscopy
Nerea Muñoz-Unceta, Jon Zugazagoitia, Aránzazu Manzano, Elisabeth Jiménez-Aguilar, M.E. Olmedo, Juan Diego Cacho, Júlio Oliveira, Manuel Dómine, Laura Ortega-Morán, Carlos Aguado, A.M. Castro Luna, Lourdes Fernández, Javier Pérez, Carme Font, C. Salvador Coloma, J. Corral, Gretel Benítez, Silverio Ros, M. Biosca, Virginia Calvo, J. Martínez, Manuel Sánchez-Cánovas, Rafael López Castro, María Sereno, Xabier Mielgo-Rubio, Francisco Aparisi, Marta Carmona, Rafael Carrión, Santiago Ponce-Aix, Marta Soares, I. Arcas Martínez-Salas, Marcial García-Morillo, Óscar Juan, Ana Blasco, Andrés J. Muñoz Martín, Luis Paz‐Ares,
Introduction Based on the high incidence of thromboembolic events (TEs) observed in lung adenocarcinomas with ALK translocations and taking into account the biological proximity of ROS1 and ALK, we conducted a retrospective analysis of patients with advanced lung carcinoma carrying rearrangements in ROS1 from 23 centres in Spain and one centre in Portugal. Methods The main objective of the study was to analyse the incidence of TE in this population, looking for predictive risk factors, and its impact ...
Tópico(s): Lung Cancer Treatments and Mutations
2020 - Elsevier BV | European Journal of Cancer
Jörgen Stenvall, Juan Carlos Fierro-González, Peter Swoboda, Karunakar Saamarthy, Qing Cheng, Briseida Cacho‐Valadez, Elias S.J. Arnér, Olof P. Persson, Antonio Miranda‐Vizuete, Simon Tuck,
Selenoproteins, in particular thioredoxin reductase, have been implicated in countering oxidative damage occurring during aging but the molecular functions of these proteins have not been extensively investigated in different animal models. Here we demonstrate that TRXR-1 thioredoxin reductase, the sole selenoprotein in Caenorhabditis elegans , does not protect against acute oxidative stress but functions instead together with GSR-1 glutathione reductase to promote the removal of old cuticle during ...
Tópico(s): Sperm and Testicular Function
2011 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Carlos Pérez‐Mejías, Ana Moreno, Juan Luis Bernal-Wormull, Isabel Cacho, María Cinta Osácar, R. Lawrence Edwards, Hai Cheng,
Abstract This study examines the first precisely dated and temporally highly resolved speleothem record from Iberia that reconstructs the Oldest Dryas (OD). The onset of cold conditions in the study area, contemporary with the beginning of Heinrich Stadial 1, is recorded at 18.13 ± 0.08 ka, with a pronounced drop of 6.1‰ in δ 13 C in 250 years. Henceforth, stadial conditions depict a period of instability in the Atlantic Meridional Overturning Circulation, peaking in freshwater input from iceberg melting ...
Tópico(s): Archaeological and Geological Studies
2021 - Cambridge University Press | Quaternary Research
David San Segundo, Juan Carlos Ruiz, Gema Fernández‐Fresnedo, María Jesús Izquierdo, C. Gómez-Alamillo, Eva Cacho, M.J. Benito, Emilio Rodrigo, R. Palomar, Marcos López‐Hoyos, M. Arias,
Immunosuppression, although crucial for short-term management, has been described in renal transplantation to be a major hurdle for long-term graft survival. Efforts have been directed at achieving a true state of allotolerance, thereby reducing the load of immunosuppression. Recently, increased frequencies of CD4(+)CD25(high) regulatory T cells (Tregs) have been described as an additional mechanism to induce alloimmune tolerance.We assessed 64 renal transplant recipients with stable renal function ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2006 - Elsevier BV | Transplantation Proceedings
Cristina Álvarez–Urturi, Montserrat Andreu, Cristina Rodríguez de Miguel, Francisco Pérez‐Riquelme, Fernando Carballo, Akiko Ono, José Cruzado, Joaquín Cubiella, Vicent Hernández, Carmen Gonzalez Mao, Elena Pérez, Dolores Salas, Mercedes Andrés, Luís Bujanda, Isabel Portillo, Cristina Sarasqueta, Enrique Quintero, Juan Diego Morillas, Ángel Lanas, Carlos Sostres, Josep M. Augé, Antoni Castells, Xavier Bessa, Ángel Lanas, Francisca González‐Rubio, Alberto Moya-Calvo, Mónica Polo-Tomás, Maria Pilar Roncales, Pilar Sebastian-Martínez, María Ángeles Valencia-Doblas, Nieves Valero-Capilla, Luís Bujanda, María E. Alkiza, Jone M. Altzibar, Pilar Amiano, Juan Arenas, Edurne Artiñano, Ángel Cosme, Isabel Egitegi, Kepa Elorriaga, José Luis Elósegui, José M. Enríquez–Navascués, Cristina Erce, Inês Gil, María A. Gutiérrez-Stampa, Marta Herreros, Elizabeth Hijona, Mariluz Jaúregui, Eva Laredo, Roberto Reséndiz Martínez, María José Mitxelena, Isabel Montalvo, Carlos Placer, Isabel Portillo, Enrique Quintero, Onofre Alarcón, Inmaculada Alonso‐Abreu, Carlos E. Palau, Mariola de la Vega-Prieto, María Luisa Díez-Fuentes, Antonio Z. Gimeno–García, Yanira González‐Méndez, Manuel Hernández‐Guerra, Renata Linertová, David Nicolás‐Pérez, Juana María Reyes-Melián, Montserrat Andreu, Cristina Álvarez, Josep M. Augé, Francesc Balaguer, Mercè Barau, Xavier Bessa, Felipe Bory, Andrea Burón, Antoni Castells, Xavier Castells, Mercè Comas, Míriam Cuatrecasas, Maria Teresa Rodríguez‐Estrada, Olga Ferrer, Imma Garrell, Jaume Grau, Rafael Guayta, Cristina Rodríguez de Miguel, María López‐Cerón, Francesc Macià, Leticia Moreira, Teresa Ocaña, María Pellisé, Mercè Piracés, Sandra Polbach, Marc Puigvehí, Cristina Rodríguez de Miguel, María Sala, Agustín Seoane, Anna Serradesanferm, Judith Sivilla, Joaquín Cubiella, Ma Belén Aguado, Susana Aldecoa, Raquel Ortega, Ana Alonso, Inés Castro, Estela Cid, Lucía Cid, Joan Clofent, Ma Luisa de Castro, Pamela Estévez, Ana Belén Fernández, Ma Dolores González, Simoneta González, Ma Carmen González-Mao, Vicent Hernández, Begoña Iglesias, Felipe Iglesias, Pilar Vieiro Iglesias, Ángeles López-Martínez, Ramiro Macenlle, Alfonso Martínez, David Carral Martínez, Carlos Caballero Menéndez, C. Méndez, José Antonio Hermo, Isabel Pérez, Carmen Portasany, Mar Rionda, Concepción Rivera, Benito Rodrı́guez, Rosa Rodríguez, Manuel Rubio, María Isolina Santiago, Miriam Vázquez, José Ángel Vázquez, Pablo Vega, Ma Carmen Vidal, Raquel Zubizarreta, Juan Diego Morillas, Luíz Carlos de Abreu, Francisco Javier Amador, Manuel Arroyo, Fernando Bandrés, M. Sanchez Barba, José Manuel Blanco, Guillermo Cacho, José L. Cantero, Juan Carrasco, Beatriz Carrascosa, Gregorio Castellano, Francisco Colina, María Chaparro, Manuel Díaz‐Rubio, José Díaz-Tasende, José Miguel Esteban López-Jamar, Conrado Fernández-Rodrı́guez, Servando Fernández-Díez, Marta Fernández-Gil, Juan Ferrándiz, Alejandro Franco, G. García-Álvarez, Aurelio Garrido, Sofía Garrido, Javier P. Gisbert, Mariano Gómez-Haba, Inés Gómez-Molíns, A González-Navarro, María José González, Belén Herranz, P Herranz, Alberto Herreros, Rosario Iglesias, Sonia Izquierdo, Carlos López, María Aranzazu López-Rubio, Alicia C Marín, José Carlos Marín-Gabriel, Carmen Martín, José‐Luis Martínez‐Guitarte, Raquel Martínez, Carmen Moliner, José Manuel Moreno Villares, Ricardo M. Alonso de Celada, Amelia Rodriguez Nogueiras, Maria T. Perez, Rafael Píriz, Carmen Plaza, Elena Polentinos-Castro, Carmen Povés, P Alonso de Ruíz, Inmaculada Salces, Francisco Sánchez-Ceballos, Cecílio Santander, Rocío Sastre, Vicente Valentín, Fernando Carballo, Miriam Alajarín, Fernando Alberca, Juan Vicente Delgado Bermejo, J. Carrillo, José Cruzado, Purificación Sánchez López, M.P. Geijo Martínez, María Dolores Navarro, Akiko Ono, Soledad Parra, Francisco Pérez‐Riquelme, Dolores Salas, Mercedes Andrés, C Beltrán Calvo, Montserrat Cabero Jimenez, Araceli Málaga, Elena Pérez, Antonio Peris, Marta Ponce, Rodrigo Jover, María Sala, Gloria Teruel,
Tópico(s): Gastric Cancer Management and Outcomes
2016 - Elsevier BV | Digestive and Liver Disease
Kate Reidy, Paulina Majchrzak, Benedikt Haas, Joachim Dahl Thomsen, Andrea Konečná, Eugene Park, Julian Klein, Alfred J. H. Jones, Klara Volckaert, Deepnarayan Biswas, Matthew D. Watson, Céphise Cacho, Prineha Narang, Christoph T. Koch, Søren Ulstrup, Frances M. Ross, Juan Carlos Idrobo,
The integration of metallic contacts with two-dimensional (2D) semiconductors is routinely required for the fabrication of nanoscale devices. However, nanometer-scale variations in the 2D/metal interface can drastically alter the local optoelectronic properties. Here, we map local excitonic changes of the 2D semiconductor MoS2 in contact with Au. We utilize a suspended and epitaxially grown 2D/metal platform that allows correlated electron energy-loss spectroscopy (EELS) and angle resolved photoelectron ...
Tópico(s): Nanowire Synthesis and Applications
2023 - American Chemical Society | Nano Letters
Miguel F. Braña, Mónica Cacho, Mario A. García, Beatriz de Pascual‐Teresa, Ana Ramos, M. Teresa Domínguez, José Manuel Pozuelo, Cristina Abradelo, Fernanda Rey-Stolle, M. Yuste, Mónica Báñez-Coronel, Juan Carlos Lacal,
Amonafide- and elinafide-related mono and bisintercalators, modified by the introduction of a π-excedent furan or thiophene ring fused to the naphthalimide moiety, have been synthesized. These compounds have shown an interesting antitumor profile. The best compound, 9, was 2.5-fold more potent than elinafide against human colon carcinoma cells (HT-29). Molecular dynamic simulations and physicochemical experiments have demonstrated that these compounds are capable of forming stable DNA complexes. ...
Tópico(s): Cancer therapeutics and mechanisms
2004 - American Chemical Society | Journal of Medicinal Chemistry
Purificación Hernández-Orte, Ernesto Franco, Carlos González Huerta, Juana Martínez García, Mariano Cabellos, J. Suberviola, Ignacio Orriols, Juan Cacho,
Wine aging in barrels is carried out to increase stability and achieve more complex aromas. In the last few years, however, the practice of macerating wine with small fragments of toasted oak (chips) has become increasingly common. This conveys similar tastes, aromas, and wooden notes to the wine as those obtained with traditional barrel aging, but much faster and at a fraction of the cost. Without proper regulation, this could lead to fraud if wine macerated with chips is offered as barrel aged ...
Tópico(s): Wine Industry and Tourism
2014 - Elsevier BV | Food Research International
David San Segundo, Juan Carlos Ruiz, María Jesús Izquierdo, Gema Fernández‐Fresnedo, C. Gómez-Alamillo, Ramón Merino, M.J. Benito, Eva Cacho, Emilio Rodrigo, R. Palomar, Marcos López‐Hoyos, Manuel Arias,
Immunosuppression in renal transplantation, although manageable in the short-term, is a major hurdle for long-term graft survival. Recently, increased frequencies of CD4CD25 regulatory T cells (Tregs) have been described as an additional mechanism that induces alloimmune tolerance.We assessed 64 renal transplant recipients with stable renal function for at least one year. Patients were divided into two groups according to the immunosuppression they were receiving at the moment of the study: one consisted ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2006 - Wolters Kluwer | Transplantation
Montserrat Rodríguez-Aguirregabiria, Fernando Lázaro-Perona, Juana Cacho-Calvo, Ma Soledad Arellano-Serrano, Juan Carlos Ramos Ramos, Eduardo Rubio‐Mora, Mariana Díaz‐Almirón, Ma José Asensio-Martín,
Carbapenem-resistant
Tópico(s): Urinary Tract Infections Management
2024 - Multidisciplinary Digital Publishing Institute | Antibiotics
Juan Luis Bernal-Wormull, Ana Moreno, Carlos Pérez‐Mejías, Miguel Bartolomé, Arantza Aranburu, Martín Arriolabengoa, Eneko Iriarte, Isabel Cacho, Christoph Spötl, R. Lawrence Edwards, Hai Cheng,
Abstract Major disruptions in the North Atlantic circulation during the last deglaciation triggered a series of climate feedbacks that influenced the course of Termination I, suggesting an almost synchronous response in the ocean-atmosphere system. We present a replicated δ18O stalagmite record from Ostolo cave in the northern Iberian Peninsula with a robust chronological framework that continuously covers the last deglaciation (18.5–10.5 kyr B.P.). The Ostolo δ18O record, unlike other speleothem ...
Tópico(s): Geological formations and processes
2021 - Geological Society of America | Geology
Jon Zugazagoitia, M. Biosca, Júlio Oliveira, M.E. Olmedo, Manuel Dómine, Ernest Nadal, J.C. Ruffinelli, N. Sánchez-Manjavacas Muñoz, A.M. Castro Luna, Berta Hernández, Maite Martínez, Iria Gallego, Eva Martínez de Castro, Carme Font, Virginia Calvo, Virginia Martínez-Marín, J. Corral, Esther Noguerón, Rebeca Mondéjar, Ignacio Escobar, C. Salvador Coloma, Óscar Juan, Manuel Sánchez Cánovas, Javier Valdivia, Manuel Ochoa, Rafael López Castro, Berta Obispo, Cristina Pangua, María Sereno, L. Fernández Franco, Xabier Mielgo-Rubio, Julia Calzas, Ana Blasco, Francisco Aparisi, L.E. Chara, Juan Francisco Grau-Béjar, Marta Soares, Ana Gómez, Víctor Zénzola, Marcial García-Morillo, Diego Cacho, Asunción Díaz-Serrano, Carlos Aguado, Santiago Ponce-Aix, J.L. González-Larriba, Andrés J. Muñoz Martín, David Lora, Luis Paz‐Ares, Aránzazu Manzano,
Thromboembolic disease is fairly common in patients with lung cancer [1–3]. This incidence seems to be higher in patients with lung adenocarcinomas [4], with approximately 15% of those with advanced stage disease developing venous thromboembolisms (VTE) during the whole course of their disease [5–7]. Pulmonary adenocarcinomas are a heterogeneous group of diseases that can be stratified according to the presence of major oncogenic driver alterations. Anaplastic lymphoma kinase ( ALK ) rearrangements are ...
Tópico(s): Lung Cancer Treatments and Mutations
2018 - European Respiratory Society | European Respiratory Journal
Juan Luis Bernal-Wormull, Ana Moreno, Miguel Bartolomé, Martín Arriolabengoa, Carlos Pérez‐Mejías, Eneko Iriarte, Cinta Osácar, Christoph Spötl, Heather Stoll, Isabel Cacho, R. Lawrence Edwards, Hai Cheng,
Recent hydroclimate studies on the Iberian Peninsula have shown a complex regional pattern in timing and intensity of climate change spanning the Younger Dryas and the Holocene. These changes are due to multifaceted interactions between climate variability that characterizes the Atlantic Ocean region and hydroclimatic processes associated with the Mediterranean climate, thus making it difficult to reconstruct centennial- and millennial-scale variability in rainfall. In this study we present a composite ...
Tópico(s): Archaeology and ancient environmental studies
2023 - Elsevier BV | Quaternary Science Reviews