By Julian Haviland, Political Editor, By Anthony Bevins, Political Correspondent, By Philip Webster, Political Reporter, From Our Correspondent, By Staff Reporters, From Stephen Taylor, By Baron Phillips, From Jonathan Wills, By Stewart Tendler, Crime Reporter, By Richard Evans, By Hugh Noyes Parliamentry Correspondent, By Frances Gibb, By Diana Geddes Education Correspondent, By the Staff of "Nature", By Pat Healy Social Services Correspondent, From Paul Routledge, Labour Editor, From Richard Ford, By David Walker, By Lucy Hodges, By John Young Agricultural Correspondent, From Arthur Osman, By Philip Webster Political Reporter, By Henry Stanhope, Defence Correspondent, From Paul Ellman, From Nicholas Ashford, From Robert Schuil, From our Correspondent, From Michael Hornsby, From Roger Boyes, From George Clark, From Richard Wigg, From Andrew McLeod, From Neil Kelly, From Harry Debelius, From Peter Hazelhurst, From Christopher Thomas, From Christopher Walker, From Robert Fisk, From David Blow, From Michael Binvon, From Our Own Correspondent, From Charles Hargrove, From Rasit Gurdilek, By Gabriel Ronay, From Mario Modiano, Lucy Hodges, Michael Ratcliffe, Irving Wardle, David Robinson, John Percival, Paul Griffiths, Hilary Finch, John Higgins, Henry A. Kissinger, PHS, David Watt, JOHN EVANS, JOHN PRINGLE, T. E. B. CLARKE, ANTHONY JACOBS, CRAIG TIMONEY, MICHAEL ROSE, PAUL OESTREICHER, M. M. FORSTER, GRAHAM WEBSTER, GERSHON ELLENBOGEN, JOHN HARRIS, JOHN F. CAMPBELL, ANTHONY HARDWICK, B. J. C. SANDERS, NORMAN SANDERS, By Tom Samstag, M. M., Gareth David, By Peter Wilson-Smith, By Jonathan Davis, Energy Correspondent, By Torin Douglas, By Sally White, Ronald Pullen, By Philip Robinson, By Peter Hill, Industrial Editor, From David Young, By Rupert Morris, Drew Johnston, Jonathan Davis, By Clive Cookson, From Nicholas Hirst, From John Woodcock, Cricket Correspondent, By Pamela Macgregor-Morris, From John Ballantine, By Norman Fox Sports Correspondent, From W. P. Reeves, From John Hennessy, From Richard Eaton, By Stuart Jones, Football Correspondent, By Paul Newman, From Michael Coleman, By Norman Fox, By Michael Phillips Racing Correspondent, By Our Racing Correspondent, By Keith Macklin, By Michael Phillips, By Nicholas Harling, By Conrad Voss Bark, Fishing Correspondent, From John Wilcockson, by Peter Waymark, Edited by Peter Davalle, By Jonathan Davis Energy Correspondent, By Christopher Warman, Arts Correspondent, Geoff Brown, Derek Winnert, Christopher Warman, Nicholas Wapshott, Ned Chaillet, Philip Howard, Richard Williams, Judy Froshaug, Stuart Jones, Michael Seely, Nicholas Keith,
... m Henry, fly me to Damascus, Duke visits Juan Carlos in Spain, Auctions today, Ecevit spends hour with ...
1982 - Gale Group | TDA
Marina Romanato, Eleonora Regueira, MÓNICA S. CAMEO, Consuelo Baldini, Lucrecia Calvo, Juan Carlos Calvo,
BACKGROUND: Human spermatozoa decondense in vitro upon exposure to heparin and glutathione. Glutathione is also the disulfide bond reducer in vivo, and heparan sulfate, a functional analogue of heparin, has been proposed as the protamine acceptor. The aim of this study was to evaluate the decondensing ability of chemically modified heparins and different glycosaminoglycans (GAGs) on isolated sperm nuclei in vitro, and to analyse the possible role of different GAGs as protamine acceptors. METHODS: ...
Tópico(s): Hormonal and reproductive studies
2005 - Oxford University Press | Human Reproduction
Marina Romanato, Vanina Laura Julianelli, M. Zappi, Lucrecia Calvo, Juan Carlos Calvo,
BACKGROUNDPrevious results from our laboratory have led us to propose heparan sulfate (HS) as a putative protamine acceptor during human sperm decondensation in vivo. The aim of this paper was to investigate the presence of glycosaminoglycans in the mammalian oocyte in an effort to better support this contention.
Tópico(s): Proteoglycans and glycosaminoglycans research
2008 - Oxford University Press | Human Reproduction
Melisa Sanchez, C. Alvarez Sedó, Vanina Laura Julianelli, Marina Romanato, Lucrecia Calvo, Juan Carlos Calvo, Vanina Andrea Fontana,
The mammalian sperm nucleus contains an unusually condensed chromatin, due to replacement of the majority of histones by protamines. However, soon after the spermatozoon penetrates the ooplasm at fertilization, decondensation of this densely packed chromatin must occur to allow formation of the male pronucleus and syngamy. Decondensation is accomplished by protamine disulfide bond reduction by oocyte glutathione and replacement of protamines by oocyte histones with the aid of an acceptor molecule. ...
Tópico(s): Reproductive Biology and Fertility
2013 - Taylor & Francis | Systems Biology in Reproductive Medicine
B. Pérez-Saborido, Carmelo Loinaz Segurola, Alberto Calvo, Juan Carlos Menéu Díaz, Manuel Abradelo de Usera, Jorge Calvo, C. Jiménez Romero, R. Sanz, Ignacio García, E. Moreno González,
Currently liver transplantation is the treatment of choice for early hepatocellular carcinoma and end-stage liver disease. We analyzed our experience to identify factors that could be used to select patients who will benefit from liver transplantation. From April 1986 to December 2001, 71 (8.7%) of 816 LT performed in our institution, were for patients with hepatocellular carcinoma. In 25 patients the tumor was observed incidental by (35.2%). All patients had liver cirrhosis, most due to hepatitis ...
Tópico(s): Liver Disease and Transplantation
2003 - Elsevier BV | Transplantation Proceedings
Melisa Sanchez, Vanina Andrea Fontana, Camila Galotto, Maite Yael Cambiasso, Cristián Sobarzo, Lucrecia Calvo, Juan Carlos Calvo, Elisa Cebral,
Male chronic alcohol abuse causes testicular failure and infertility. We analyzed the effects of moderate sub-chronic alcohol intake on sperm morphology, capacitation, fertilization and sperm head decondensation. CF-1 male mice were administered 15% ethanol in drinking water for 15 days; control mice received ethanol-free water. Similar patterns of tyrosine phosphorylation were observed in capacitated spermatozoa of control and treated males. Percentage of hyperactivation (H) and spontaneous (SAR) ...
Tópico(s): Ovarian function and disorders
2018 - Bioscientifica | Reproduction
Guiomar Pérez de Nanclares, José Ramón Bilbao, Begoña Calvo, Juan Carlos Vitoria, Federico Vázquez, Luís Castaño,
A bstract : The VNTR region located at the 5′‐end of the insulin gene on chromosome 11p15.5 is linked to susceptibility to type 1 diabetes mellitus (T1DM), and class I alleles have been associated with increased risk of disease, whereas class III alleles are considered to be protective. Although a potential effect on the expression level of thymic insulin and a consequent abnormal tolerance have been proposed as an explanation, it is still not clear whether the association is specific for T1DM or whether ...
Tópico(s): Pancreatic function and diabetes
2003 - Wiley | Annals of the New York Academy of Sciences
José Ramón Bilbao, Ainhoa Martín‐Pagola, Guiomar Pérez de Nanclares, Begoña Calvo, Juan Carlos Vitoria, Federico Vázquez, Luís Castaño,
A bstract : Autoimmune disorders such as type 1 diabetes (T1DM), celiac disease (CD), and Addison's disease (ADD) develop in individuals with genetic susceptibility that are exposed to environmental triggering factors not completely defined. Patients with an autoimmune disease (and their relatives) are at increased risk of developing another disorder, and this might be caused by a common genetic origin of autoimmunity; for example, HLA class II region in 6p21 shows a very strong association with most ...
Tópico(s): T-cell and B-cell Immunology
2003 - Wiley | Annals of the New York Academy of Sciences
Inmaculada Pulido‐Calvo, Juan Carlos Gutiérrez‐Estrada,
Recently, Computational Neural Networks (CNNs) and fuzzy inference systems have been successfully applied to time series forecasting. In this study the performance of a hybrid methodology combining feed forward CNN, fuzzy logic and genetic algorithm to forecast one-day ahead daily water demands at irrigation districts considering that only flows in previous days are available for the calibration of the models were analysed. Individual forecasting models were developed using historical time series ...
Tópico(s): Energy Load and Power Forecasting
2008 - Elsevier BV | Biosystems Engineering
Alfonso J. Cruz‐Jentoft, J.J. Calvo, Juan Carlos Durán, J Ordóñez, R. de Castellar,
Background: Undernutrition is a common problem in older individuals that may be related to a low protein dietary intake. Oral supplements may improve the health status in this population, but their use may be limited by compliance and side effects.Objectives To evaluate effects of an oral supplement of protein and fibre on compliance, on nutritional status, and on intestinal habits in nursing home residents.Method: A prospective observational study was carried out in 66 Spanish nursing homes. 358 ...
Tópico(s): Dysphagia Assessment and Management
2008 - Springer Science+Business Media | The journal of nutrition health & aging
Eudald Carbonell, José Marı́a Bermúdez de Castro, Josep M. Parés, Alfredo Pérez-González, Gloria Cuenca‐Bescós, Andreu Ollé, Marina Mosquera, Rosa Huguet, Jan van der Made, Antonio Rosas, Robert Sala, Josep Vallverdú, Nuria Garcı́a, Darryl E. Granger, María Martinón‐Torres, Xosé Pedro Rodríguez Álvarez, Greg M. Stock, Josep María Vergès, Ethel Allué, Francesc Burjachs, Isabel Cáceres, Antoni Canals, Alfonso Benito‐Calvo, Juan Carlos Díez Fernández-Lomana, Marina Lozano, Ana Mateos, Marta Navazo Ruíz, Jesús Rodrı́guez, Jordi Rosell, Juan Luís Arsuaga,
Tópico(s): Archaeology and ancient environmental studies
2008 - Nature Portfolio | Nature
Ángela Vázquez-Calvo, Juan‐Carlos Sáiz, Francisco Sobrino, Miguel A. Martín-Acebes,
Valproic acid (VPA) is a short-chain fatty acid commonly used for treatment of neurological disorders. As VPA can interfere with cellular lipid metabolism, its effect on the infection of cultured cells by viruses of seven viral families relevant to human and animal health, including eight enveloped and four nonenveloped viruses, was analyzed. VPA drastically inhibited multiplication of all the enveloped viruses tested, including the zoonotic lymphocytic choriomeningitis virus and West Nile virus ( ...
Tópico(s): Virology and Viral Diseases
2010 - American Society for Microbiology | Journal of Virology
Marta Navazo Ruíz, Rodrigo Alonso Alcalde, Alfonso Benito‐Calvo, Juan Carlos Díez Fernández-Lomana, Alfredo Pérez‐González, Eudald Carbonell,
Many caves in Sierra de Atapuerca contain archaeological and anthropological remains from the Early Pleistocene until the Holocene. The fi rst half of the Late Pleistocene (MIS 4 and 3) has only been detected in open air deposits discovered on the basis of total cover surface surveys. Excavation at one of them, Hundidero, began in 2004. The Middle Paleolithic tool record spans the period between 70 ka and 56 ka. The technological and typological features of Hundidero, along with records from 30 other ...
Tópico(s): Evolution and Paleontology Studies
2011 - Elsevier BV | Archaeology Ethnology and Anthropology of Eurasia
Inmaculada Pulido‐Calvo, Juan Carlos Gutiérrez‐Estrada, Dragan Savić,
Tópico(s): Hydrology and Drought Analysis
2011 - Springer Science+Business Media | Water Resources Management
Inmaculada Pulido‐Calvo, Juan Carlos Gutiérrez‐Estrada, Rafael Luque, José Roldán Cañas,
Research Article| August 01 2006 Regulating reservoirs in pressurized irrigation water supply systems I. Pulido-Calvo; I. Pulido-Calvo 1Dpto. Ciencias Agroforestales, Universidad de Huelva, EPS, Campus Universitario de La Rá bida, 21819 Palos de la Frontera (Huelva), Spain Tel.: +34-959-217533 Fax: +34-959-217528; E-mail: ipulido@uhu.es Search for other works by this author on: This Site PubMed Google Scholar J. C. Gutiérrez-Estrada; J. C. Gutiérrez-Estrada 2Dpto. Física Aplicada, Universidad de Córdoba, ...
Tópico(s): Wastewater Treatment and Reuse
2006 - UWA Publishing | Journal of Water Supply Research and Technology—AQUA
Ángela Vázquez-Calvo, Juan‐Carlos Sáiz, Kenneth C. McCullough, Francisco Sobrino, Miguel A. Martín-Acebes,
Virus infection of host cells requires that entry into the cell results in efficient genome release leading to translation and replication. These initial steps revolving around the entry and genomic release processes are crucial for viral progeny generation. Despite the variety of receptors used by viruses to initiate entry, evidence from both enveloped and non-enveloped viral infections is highlighting the important role played by intracellular acidic compartments in the entry of many viruses. ...
Tópico(s): Calcium signaling and nucleotide metabolism
2012 - Elsevier BV | Virus Research
Maria José Garcia‐Fernandez, Laura Martínez-Calvo, Juan‐Carlos Ruiz, M. R. Wertheimer, Ángel Concheiro, Carmen Alvarez‐Lorenzo,
Abstract Low‐pressure plasma‐polymerized ethylene film coatings rich in bonded oxygen groups (L‐PPE:O) were deposited on poly(ethylene terephthalate; PET) in order to act as hosts for antimicrobial drugs. Increasing O 2 content in the ethylene (C 2 H 4 )/Ar–diluted oxygen (O 2 ) gas mixture reduced the deposition rate, but increased the concentration of bonded oxygen, [O], including that of carboxylic acid groups, [COOH], as determined by X‐ray photoelectron‐ (XPS) and Fourier transform infrared (FTIR) spectroscopies, ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2012 - Wiley | Plasma Processes and Polymers
Emilio Calvo, Juan Carlos Santos,
Tópico(s): Decision-Making and Behavioral Economics
2000 - Springer Science+Business Media | International Journal of Game Theory
Emilio Calvo, Juan Carlos Santos,
A multichoice game is a generalization of a cooperative TU game in which each player has several activity levels. We study the solution for these games proposed by Van Den Nouweland et al. (1995) [Van Den Nouweland, A., Potters, J., Tijs, S., Zarzuelo, J.M., 1995. Cores and related solution concepts for multi-choice games. ZOR-Mathematical Methods of Operations Research 41, 289–311]. We show that this solution applied to the discrete cost sharing model coincides with the Aumann-Shapley method proposed ...
Tópico(s): Game Theory and Applications
2000 - Elsevier BV | Mathematical Social Sciences
Patricia Aguilar‐Calvo, Juan Carlos Espinosa, Belén Pintado, Alfonso Gutiérrez‐Adán, Elia Alamillo, Alberto Miranda Bedate, Irene Prieto, Alex Bossers, Olivier Andréoletti, Juan María Torres,
The prion protein-encoding gene (prnp) strongly influences the susceptibility of small ruminants to transmissible spongiform encephalopathies (TSEs). Hence, selective breeding programs have been implemented to increase sheep resistance to scrapie. For goats, epidemiological and experimental studies have provided some association between certain polymorphisms of the cellular prion protein (PrP(C)) and resistance to TSEs. Among them, the Q/K polymorphism at PrP(C) codon 222 (Q/K222) yielded the most promising ...
Tópico(s): Neurological diseases and metabolism
2013 - American Society for Microbiology | Journal of Virology
Patricia Carulla, Franc Llorens, Andreu Matamoros‐Angles, Patricia Aguilar‐Calvo, Juan Carlos Espinosa, Rosalina Gavı́n, Isidró Ferrer, Giuseppe Legname, Juan María Torres, José Antonio del Rı́o,
The cellular prion protein (PrP(C)) has been associated with a plethora of cellular functions ranging from cell cycle to neuroprotection. Mice lacking PrP(C) show an increased susceptibility to epileptic seizures; the protein, then, is neuroprotective. However, lack of experimental reproducibility has led to considering the possibility that other factors besides PrP(C) deletion, such as the genetic background of mice or the presence of so-called "Prnp flanking genes", might contribute to the reported ...
Tópico(s): Neurological diseases and metabolism
2015 - Nature Portfolio | Scientific Reports
Miguel A. Martín-Acebes, Ángela Vázquez-Calvo, Juan‐Carlos Sáiz,
Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases such as yellow fever, dengue, West Nile encephalitis, tick-borne encephalitis, Kyasanur Forest disease, tick-borne encephalitis, or Zika disease. This viral genus groups >50 viral species of small enveloped plus strand RNA virus that are phylogenetically closely related to hepatitis C virus. Importantly, the flavivirus life cycle is intimately associated to host cell lipids. Along this line, flaviviruses rearrange ...
Tópico(s): Malaria Research and Control
2016 - Elsevier BV | Progress in Lipid Research
Emilio Calvo, Juan Carlos Santos,
This paper is devoted to the study of solutions for cooperative TU-games which admit a potential function, such as the potential associated with the Shapley value (introduced by Hart and Mas-Colell). We consider the finite case and the finite type continuum. Several characterizations of this family are offered and, as a main result, it is shown that each of these solutions can be obtained by applying the Shapley value to an appropriately modified game. We also study the relationship of the potential ...
Tópico(s): Game Theory and Applications
1997 - Elsevier BV | Mathematical Social Sciences
Juan Manuel Sánchez Calvo, Juan Carlos Alados, Luis Ros Vidal, José L. de Francisco, María Dolores López Prieto,
To compare the RT-PCR Allplex SARS-CoV-2/FluA/FluB/RSV Assay (Allplex assay) with other methods of detection of VOC B.1.1.7. Suspected and non-suspected cases of VOC B.1.1.7 were defined according to the VirSNiP assay, which detects N501Y and deletion H69-V70. For pre-screening, the Allplex™ and TaqPath assays were used. One hundred and sixteen suspected and 113 non-suspected cases were included. In the suspected cases, the Allplex assay showed N-gene dropout, or delayed Ct values of 6.27 ± 1.21 and ...
Tópico(s): Viral gastroenteritis research and epidemiology
2021 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Vanina Laura Julianelli, B. Farrando, C. Alvarez Sedó, Lucrecia Calvo, Marina Romanato, Juan Carlos Calvo,
Human sperm nuclear decondensation in vivo involves protamine disulfide bond reduction by glutathione (GSH) and protamine/histone exchange, presumably with heparan sulfate (HS) as the protamine acceptor. The aim of the present study was to test the hypothesis that these two events occur simultaneously rather than sequentially, as has been hitherto accepted, and to test for the presence of HS in the human oocyte.Spermatozoa and isolated sperm nuclei obtained from normal volunteers were exposed in vitro ...
Tópico(s): Ovarian function and disorders
2012 - Oxford University Press | Human Reproduction
Produção Nacional
Revisado por pares
Silvia Helena García-Braz, María Prados‐Privado, Luiz Carlos Silveira Zanatta, José Luís Calvo‐Guirado, Juan Carlos Prados‐Frutos, Sérgio Alexandre Gehrke,
Background: The goal of this study was to analyze the stress distribution on two types of extra-short dental implants with 5 mm of length: An internal hexagon (IH) and morse taper connection (MT). Methods: The three-dimensional model was composed of trabecular and cortical bone, a crown, an extra-short dental implant and their components. An axial load of 150 N was applied and another inclined 30° with the same magnitude. Results: Stress concentrations on the IH implant are observed in the region ...
Tópico(s): Bone Tissue Engineering Materials
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Marta Tesone, Ricardo Martins Oliveira-Filho, Luiz Biella de Souza Valle, Juan Carlos Calvo, J. Lino Barañao, V. G. Foglia, Eduardo H. Charreau,
Tópico(s): Estrogen and related hormone effects
1980 - Springer Science+Business Media | Diabetologia
Juan Carlos Calvo, Luiz Biella de Souza Valle, JOS Eacute LINO S. BARAÑAO, Marta Tesone, Eduardo H. Charreau,
Impaired testosterone biosynthesis in Leydig cells from streptozotocin treated rats is correlated with the reduced activity of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and isocitrate dehydrogenase. The results shown demonstrate that in the diabetic state the activity of these enzymes is reduced by almost 50 to 59% from normal levels. Insulin treatment restored their activities to normal levels.
Tópico(s): Diet, Metabolism, and Disease
1979 - Thieme Medical Publishers (Germany) | Hormone and Metabolic Research
JOSÉLINO S. BARAÑAO, Marta Tesone, Ricardo Martins Oliveira-Filho, Violeta A. Chiauzzi, Juan Carlos Calvo, Eduardo H. Charreau, Ricardo S. Calandra,
Five groups of immature (30‐day‐old) intact male rats were injected daily for ten days with different doses of ovine prolactin (5, 10, 25, 50, or 500 μg per rat per day). At the end of the treatment period, the animals were killed, serum was collected for LH and androgens measurements and weights of testes, prostates, and epididymides were recorded. Available and exchangeable cytoplasmic and total nuclear KC1‐extractable androgen binding sites in the prostate gland were determined using the synthetic ...
Tópico(s): Estrogen and related hormone effects
1982 - Wiley | Andrology
JOS Eacute LINO S. BARAÑAO, BEATRIZ LEGNANI, VIOLETA A. CHIAUZZI, L Bertini, María Olga Suescun, Juan Carlos Calvo, Eduardo H. Charreau, Ricardo S. Calandra,
Testosterone metabolism in androgen target tissues of immature Wistar male rats was studied after the injection of ovine PRL (oPRL) or after changes in PRL levels induced by the administration of dopaminergic agonists or antagonists. Treatment with oPRL (500 μg/rat-day) for 10 days, starting on day 30 of age, caused a significant increase in testes and sex accessory organ weights and a concomitant augmentation in prostatic 5α-reductase activity. This effect, however, was not observed in epididymis ...
Tópico(s): Sperm and Testicular Function
1981 - Oxford University Press | Endocrinology