Andrew Robson, Lilian Thuram, Alyn Shipton, Michael Joseph, Pat McAuley, Robert Cole, Lucas Radebe, Andrew Pierce, DJM, James Moore, Zahid Hussain, Adam Sherwin Media Reporter, Don Howe, Thierry Henry, Jose-Luis Chilavert, Michael Owen, Richard Hobson, Jane Bolton, John Belstead, Philip Howard, Shay given, Carol Midgley, A. Shell, David Chater, David Trezeguet, James Bone, Rachel Campbell-Johnston, Nic Hopkins, Tom Finney, Tim Williams, Richard S. D. Ogilvy, Carl Mortished, Patrick Kidd, Vitor Baia, Sam Lister, Clare Stewart, Joe Joseph, Giles Coren, Simon Peter Firth, Ben Webster Transport Correspondent, David McVay, Howard Davies, Thrasy Petropoulos, Gabriel Batistuta, Jennai Cox Fitness Editor, Angus MacLeod Scottish Political Correspondent, Gary Lineker, Terry Butcher, Dominic Walsh, Tom Bawden, Rachel Holmes, Pauleta, Vincenzo Montella, Rory Watson, Nigel Hawthorne, Billy Wright, Jimmy Greaves, Gianluigi Buffon, Ruth Gledhill Religion Correspondent, Richard Ford Home Correspondent, Alan Hamilton, Stephen Farrell, Kevin Sampson, David Seaman, Simon Barnes Chief Sports, Jimmy Armfield, David Hands, Raul, Mark Bushell, Mark Pougatch, Matt Dickinson Chief Football Correspondent, Ian McIntyre, Greg Hurst, Anthea Lawson, Nicholas Wapshott, Caroline Merrell Banking Correspondent, Stanley Matthews, Christian Vieri, Simon Tait, Roger Scruton, Paula Hawkins, Peter Wright, Robert Cole City Correspondent, David Rowan, Vanora Bennett, Bobby Charlton, Thomas Linke, Sarah Johnson, Oliver Kahn, Ray Wilson, Tom Baldwin, Mark Henderson Science Correspondent, Martin Peters, Michael Gardiner, Karen Homer, Simon de Bruxelles, John Barnes, Geoffrey Dean, Roberto Carlos, Rio Ferdinand, J. M. Bryce, Edward Young, Neil Harman Tennis Correspondent, Martin Samuel, Raymond Keene, Rui Costa, John Russell Taylor, Matt Dickinson, Jerzy Dudek, Fernando Hierro, Johnny Haynes, Jonathan Dimbleby, Bronwen Maddox, Melissa Kite, Russell Hotten, Richard Owen, Tola Awogbamiye, Thomas Sorensen, Isadora Shilling, Noel Gallagher, Nick Hasell, Robbie Fowler, Lucio, Steve Claridge, Bryan Robson, David Hands Rugby Correspondent, Bobby Moore, Elizabeth Price, Francesco Totti, John Allison, T. C. B. Dehn, Nicholas Bethell, Tom Bentley, Anne Ashworth, Nick Szczepanik, Joanna Pitman, Mary Ann Sieghart, James Doran, Giles Whittell, Philip Webster Political Editor, Christopher Walker, Anne E. Kornblut, Juan Sebastian Veron, Roberto Ayala, Kevin McCarra, Alessandro Nesta, Chris McGrath, George Caulkin, Tim Wapshott, John Crosland and Michael Horsnell, Stewart Tendler and Andrew Pierce, Ingrid Mansell, Michael Austin, Peter Riddell, Lea Paterson Economics Editor, Geoff Hurst, Alex Benady, Nasser Hussain, Ben Webster, David Charter Chief Political Correspondent, Philip Webster, Richard Owen and Michael Evans Defence Editor, Michael Dynes, Simon Jenkins, Gary Duncan Economics Correspondent, Catherine Philp, Martin Waller, Michael Horsnell, Chris Ayres, Wilf Mannion, Alan Coren, Laura Peek, Benedict Nightingale, Angus Batey, Richard Nunn, Richard Beeston and Michael Evans, Stephen Dalton, Richard Morrison, Tim Lawson-Cruttenden, Bill Edgar, Alice Miles, Fabien Barthez, Adam Sherwin, Ray Davies, Roger Byrne, Sally Patten, Ashley Cole, Conal Gregory, Juan Valeron, Tom Rasmussen, Hernan Crespo, Boyd Goldie, Patience Wheatcroft, Jack Charlton, David Lister Ireland Correspondent,
... England My World Cup Alessandro Nesta Italy Roberto Carlos Brazil Lucas ... year TO WATCH Juan Valeron Spain TO WATCH Rui Costa Portugal TO WATCH ...
2002 - Gale Group | TDA
Salvador Aznar Benitah, Pilar F. Valerón, Juan Carlos Lacal,
Rho GTPases are overexpressed in a variety of human tumors contributing to both tumor proliferation and metastasis. Recently, several studies demonstrate an essential role of transcriptional regulation in Rho GTPases-induced oncogenesis. Herein, we demonstrate that RhoA, Rac1, and Cdc42 promote the expression of cyclooxygenase-2 (COX-2) at the transcriptional level by a mechanism that is dependent on the transcription factor nuclear factor-κB (NF-κB), but not Stat3, a transcription factor required ...
Tópico(s): Estrogen and related hormone effects
2003 - American Society for Cell Biology | Molecular Biology of the Cell
Salvador Aznar Benitah, Carolina Espina, Pilar F. Valerón, Juan Carlos Lacal,
Tópico(s): Metabolism, Diabetes, and Cancer
2003 - Springer Science+Business Media | Revista de Oncología
Salvador Aznar Benitah, Pilar F. Valerón, Hallgeir Rui, Juan Carlos Lacal,
The involvement of Rho GTPases in signal transduction pathways leading to transcription activation is one of the major roles of this family of GTPases. Thus, the identification of transcription factors regulated by Rho GTPases and the understanding of the mechanisms of their activation and its biological outcome are of great interest. Here, we provide evidence that Rho GTPases modulate Stat5a, a transcription factor of the family of signal transducers and activators of transcription. RhoA triggers ...
Tópico(s): NF-κB Signaling Pathways
2003 - American Society for Cell Biology | Molecular Biology of the Cell
Salvador Aznar Benitah, Pilar F. Valerón, Carolina Espina, Juan Carlos Lacal,
Tópico(s): Cell death mechanisms and regulation
2003 - Elsevier BV | Cancer Letters
Teresa Gómez del Pulgar, Salvador Aznar Benitah, Pilar F. Valerón, Carolina Espina, Juan Carlos Lacal,
Abstract Rho proteins belong to the small GTPases superfamily. They function as molecular switches that, in response to diverse stimuli, control key signaling and structural aspects of the cell. Although early studies proposed a role for Rho GTPases in cellular transformation, this effect was underestimated due to the fact that no genetic mutations affecting Rho‐encoding genes were found in tumors. Recently, it has become evident that Rho GTPases participate in the carcinogenic process by either ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2005 - Wiley | BioEssays
Salvador Aznar Benitah, Pilar F. Valerón, Linda Van Aelst, Christopher J. Marshall, Juan Carlos Lacal,
The high incidence of overexpression of some members of the Rho family of GTPases in human tumors suggests that (1) these proteins are involved in cancer onset, and (2) they are potential candidates for a therapeutic intervention. In recent years, the characterization of downstream effectors to Rho GTPases has provided crucial clues on the general cellular effects that permit aberrant proliferation and adhesiveness of tumor cells. The activation of many of these effector proteins in turn results in ...
Tópico(s): Cancer-related Molecular Pathways
2004 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Nieves Embade, Pilar F. Valerón, Salvador Aznar Benitah, Eduardo López‐Collazo, Juan Carlos Lacal,
Rho proteins, members of the Ras superfamily of GTPases, are critical elements in signal transduction pathways governing cell proliferation and cell death. Different members of the family of human Rho GTPases, including RhoA, RhoC, and Rac1, participate in the regulation of apoptosis in response to cytokines and serum deprivation in different cell systems. Here, we have characterized the mechanism of apoptosis induced by Rac1 in NIH 3T3 cells. It requires protein synthesis and caspase-3 activity, ...
Tópico(s): Neuroscience and Neuropharmacology Research
2000 - American Society for Cell Biology | Molecular Biology of the Cell
Salvador Aznar Benitah, Pilar F. Valerón, Sonia V. del Rincón, Leandro Fernández‐Pérez, Rosario Perona, Juan Carlos Lacal,
Stats (signal transducers and activators of transcription) are latent cytoplasmic transcription factors that on a specific stimulus migrate to the nucleus and exert their transcriptional activity. Here we report a novel signaling pathway whereby RhoA can efficiently modulate Stat3 transcriptional activity by inducing its simultaneous tyrosine and serine phosphorylation. Tyrosine phosphorylation is exerted via a member of the Src family of kinases (SrcFK) and JAK2, whereas the JNK pathway mediates ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2001 - American Society for Cell Biology | Molecular Biology of the Cell
Nabila Rodríguez Valerón, Tiffany Mak, Leonie J. Jahn, Juan Carlos Arboleya, Pia M. Sörensen,
The term kokumi is used to describe sensory attributes of mouthfulness, lingeringness, and thickness. It is caused by γ-glutamyl di- and tri-peptides, and is especially prevalent in fermented food products. This study explores the influence of substrate, microbial strain and fermentation time on the development of kokumi peptides in barley and sorghum misos, both grain-based fermentations produced by Aspergillus oryzae. Unlike other reports, kokumi peptide evolution is considered in the context ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2023 - Elsevier BV | LWT
Nabila Rodríguez Valerón, Tiffany Mak, Leonie J. Jahn, Juan Carlos Arboleya, Pia M. Sörensen,
Current food production methods and consumption behaviours are unsustainable and contribute to environmental harm. One example is food waste—around 38% of food produced is wasted each year. Here, we show that two common food waste products, wheat bran and brewer’s spent grain, can successfully be upcycled via miso fermentation. During the fermentation process, kokumi γ-glutamyl peptides, known to increase mouthfulness, are produced; these include γ-ECG (oxidized), γ-EVG, γ-EV, γ-EE, γ-EF, and γ-EL. ...
Tópico(s): GABA and Rice Research
2023 - Multidisciplinary Digital Publishing Institute | Foods
Pilar F. Valerón, Salvador Aznar Benitah, Juan Carlos Lacal,
The knowledge of the cellular events that take place during the development of a disease is crucial for establishing effective therapies. During the last three decades, the design of antitumoral agents has been primarily based on the fact that tumor cells exhibit a higher proliferation rate than “normal” cells. As a consequence, drugs that are cytotoxic either by affecting DNA replication, cellular morphological integrity, or cellular metabolism, such as alkylating, antimetabolites and microtubule- ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2004 - Springer Science+Business Media | Progress in molecular and subcellular biology
Giordano Espinosa Rodríguez, Juan Carlos Arboleya, Diego Prado Vásquez, Rasmus Munk, Nabila Rodríguez Valerón,
The holistic cuisine is an interdisciplinary work in gastronomy to understand food and gastronomic experiences in different ways. It encompasses different fields and knowledge from natural to social science. This concept created by Rasmus Munk, the chef from Alchemist restaurant in Copenhagen, shows how different fields can work together. Inspired in the concept of alchemy, the chef brings a new vision of gastronomy, understanding the world holistically. Since alchemists tried out to distill light ...
Tópico(s): Olfactory and Sensory Function Studies
2022 - Elsevier BV | International Journal of Gastronomy and Food Science
Ane Salvador, Salvador Aznar Benitah, Pilar F. Valerón, Sonia V. del Rincón, Leandro Fernández‐Pérez, Rosario Perona, Juan Carlos Lacal,
Tópico(s): Microtubule and mitosis dynamics
2001 - Elsevier BV | European Journal of Cancer
Andrea Alemany, Pere Millat-Martínez, Marc Corbacho-Monné, Clara Suñer, Cristina Galván‐Casas, Caty Carrera, Dan Ouchi, Núria Prat, Jordi Ara, Núria Nadal, Ricard Riel, Blanca Funollet, Carmen Ojeda-Ciurana, Lluis Esteve Balague, Betlem Salvador-González, Anna Forcada Arcarons, Josep Vidal‐Alaball, Isabel del Cura-González, Ricardo Rodríguez-Barrientos, Rafel Ramos, Alberto Alum Bou, Elsa Mondou, Mireia Torres, Neus Campins, Ana Pardo Sanz, Yonggiang Tang, Miquel Ángel Rodríguez-Arias, Quique Bassat, Bonaventura Clotet, Natàlia Casamitjana, Adrià Aguilar-Uroz, Adrià Rosell-García-Ufano, Adrián Escudero Planas, Aida Baelo, Ainhoa Villahoz Martín, Alberto Moreno López, Alberto Roldán-Ruiz, Alberto Santana Briongos, Alberto Tejera Bodas, Alejandro Alonso-Vallés, Alejandro Fletes-Pérez, Alejandro Hueso Mor, Alex Boluda, Alex Santamaria, Alicia Santos Diestro, Almudena Revuelta-Álvarez, Álvaro Moreno Moreno, Ana Ortega de Felipe, Ana Chen-Ye, Ana Blázquez Valerón, Ana Belén Rodríguez Pérez, Ana Laura Tristán Morgalo, Ana Luisa Fernández-Allende, Andrea Bagán-Trejo, Andrés Fernández Juan, Ángel Zalve-Cano, Anna Mateo-Martínez, Antonio Valero Galván, Antonio Egidos-Plaja, Ariadna Jorge, Arturo Fraile Torres, Azahara Maria Pareja Leal, Bárbara Viader Castro, Barbara Fernandez Beato, Barbara Naveira Menchen, Beatriz Martin Poyatos, Beatriz García-Martínez, Belén Rodrigo Testillano, Belen Blanco Tejedor, Blanca López Pérez, Blanca Mencía Hernanz, Camila González-Beiras, Carlos Batres, Carlos Batres, Carmen Nuñez Garcia, Carmen Merino-Rodríguez, Carolina Rodríguez-Gilabert, Celia Bonilla Penedo, Celia Bonilla Penedo, Christian Casado Gomez, Claudia Gonzalez Perez, Claudia Galindo-Tomás, Cristina Peral Bolaños, Cristina Blanco-Montes, Cristina Lupu-Yakovleva, Cristina Lopez Ruiz, Cristina Perez Mayoral, Cristina Fornes, Cristobal Garcia Corrochano, Daniel Gallardo Álvarez, Daniel Navarro Sanz, David Sanz Barrio, Debora Ramet Meseguer, Edna Margarita Vera-Jurado, Eduardo Perez Costa, Eilen Junet Bustillos-Sebastian, Elena Palomar Casado, Elena Dorrego Guerrero, Elena Medina Mateos, Elisa Rebeca Aragón Gaspar, Elisabeth Herrero Vila, Enriqueta Paez Herrera, Esmeralda Rojas Powel, Esther Robres Medialdea, Esther Vall-Ribalta, Eva Lopez Perez, Felicia Mihaela Fer, Fernanda Vazquez Ángeles, Fernando Tirado Bejarano, Ferran Prats-Domenech, Ferran Borràs Martí, Gabriela Ardila-Mejia, Gèlia Costes, Gema Gómez Arquero, Gemma Flores‐Mateo, Guillem Pintos‐Morell, Helena Mira-Centelles, Ignacio Astola Requena, Ignacio Ortega Martin, Iker Leivas-Gutierrez, Irene Escribano Valenciano, Irene Muñoz Gomez, Irina Ortega, Isabel Montserrat-Lloan, Itziar Gamboa, Jacobo Rodríguez de Torres de Paul, Jordi Cahís, Jordi Muñoz-Martinez, Jorge Iglesias Bermejo, Joselvis Virginia Cejas López, Josep Canudas, Juan Antonio García Lucas, Juan Carlos Martínez-Pino, Juana Torres Martínez, Judit Pujol-Corney, Judith González Jiménez, Júlia Gurí, Julio Labella Martín, Laia Garcia-Cano, Lara Sonsoles Perez Plata, Laura Muñoz Álvaro, Laura Rodríguez Andrés, Laura Vega Ruiz, Laura Cuevas Valiente, Laura Díaz Rodríguez, Laura Puigros, Lavinia Cristina Piciorang, Leticia Escudero, Liliana Figueroa Caballero, Lluna Ferrerfàbrega-Costals, Lucía Costafreda-Hernández, Lucía De-Paúl, Luis González Fernández-Medina, Ma Carmen Moliner Prada, Ma Cristina Berriochoa Martínez de Pisón, Maria Blanco Blasco, Maria Gil Jorge, María Cortijo Caballero, María Ubals, M. Lourdes Gonzalez‐Miret, Maria Alicia Guilloto López, Maria Concepción Moreno Calvo, María del Rosario Gil García, María Inmaculada Dueñas Román, Maria Josefa Gonzalez Sanchez, María Luisa Nicolás Campoy, Maria Luz González Velayos, Mario Mejías Zori, Mario Oliva Maqueda, Mario Caño de la Cruz, Mariona Palau-Morral, Marta Martín-Muñoz, Marta Cereceda Meca, Marta Díaz Urbina, Martha VerónicaPlazas, Martí Vall-Mayans, Martí Blasco, Mary Jane Chu-Sifuentes, Miguel García de Villasladad Peñaranda, Miguel Hernanz Sotoca, Miguel Iglesias Gonzalez, Miguel Ángel Labrador-Galván, Miguel Rodrigo de Vivar Azcarate, Miquel Gil-Fibla, Miquel Formentí-Pallarés, Mireia Esteve-Tugues, Miriam Juanes Perez, Miriam López Rubio, Mirian Recuero Renales, Mònica Hijós-Rullo, Montserrat Lleonart-Abadia, Nadia Finelli, Naiara Rojas-Bertier, Nataly Reyes-Calderón, Nerea Casado Larrañaga, Nerea Nuria Zurita Castrosin, Noélia Álvarez-Nieto, Nuria Leiva-Mora, Olga Tomillo-Martín, Omar Belghazi, Oriol Buscà, Pablo Mendoza Cediel, Pablo Macedo, Patricia Rodríguez Barroso, Patricia Ruiz Álvarez, Patricia Morales López, Patricia Jimenez Vara de Rey, Paz Lozano Ginés, Pilar Bris Rodriguez, Pilar Martínez-Alamillo, Rafa Salmerón Martínez, Raquel Botello Ariza, Raquel Vaquero Mena, Raquel González-Alonso, Raul Kaczmarczyk, Rita Barnadas Vintró, Rodrigo Hontecillas Martínez, Rosa Ribot-Rodríguez, Rosa Escobar-Sánchez, Rosario Paloma Montes Trinidad, Rubén Martínez Quintana, Ruben Arnay Arrogante, Ruben Berjon Sanchez, Ruben Picazo Navarro, Rubén Bastos, Samuel Martín Molinero, Samuel Dan Israel-Benchaya, Sandra Muñoz-Burguillo, Sandra Rodríguez-Salvador, Sara Avila, Sara Corral Gayubas, Sergio Nuñez Sánchez, Sofía Torres Weber, Susana Encabo Lopez, Teresa Torices Rasines, Valentí Sallas, Verónica Curto-Vicente, Verónica Gómez Hijosa, Verónica Daimiel-Pedrote, Verónica Gozalo, Vicente Barrios López, Virginia Ivette Castillo Montoya, Yuri Espinoza Pérez, María CristinaBerriochoa Martínez de Pisón, David Muñoz Castillo, Carlos Donato, Isabel García García,
Anti-COVID-19 hyperimmune immunoglobulin (hIG) can provide standardized and controlled antibody content. Data from controlled clinical trials using hIG for the prevention or treatment of COVID-19 outpatients have not been reported. We assessed the safety and efficacy of subcutaneous anti-COVID-19 hyperimmune immunoglobulin 20% (C19-IG20%) compared to placebo in preventing development of symptomatic COVID-19 in asymptomatic individuals with SARS-CoV-2 infection.We did a multicentre, randomized, double- ...
Tópico(s): Dermatological and COVID-19 studies
2023 - Elsevier BV | EClinicalMedicine
Rafael González, Alberto García‐Salido, David Roca Pascual, María Slöcker Barrio, Juan Carlos de Carlos Vicente, María Slöcker Barrio, A. Bustinza Arriortúa, Jesús López‐Herce, Juan Carlos de Carlos Vicente, Maite Cuervas‐Mons Tejedor, Pedro Pablo Oyágüez Ugidos, Iolanda Jordán, Carmina Guitart, Sonia Sanchíz Cárdenas, Javier Gil-Antón, Belén Joyanes, Ainhoa Jiménez Olmos, Antonio Rodrı́guez-Núñez, Javier Trastoy‐Quintela, Alexandra Hernández Yuste, Laura Díaz Munilla, Carlos Solís Reyes, Laura Medina Ramos, David Roca Pascual, Joan Ballcels Ramírez, Mario Sánchez Fernández, Inés Leóz Gordillo, C Rey, Alfredo Molina Cambra, Manuel González-Ripoll Garzón, José Fernández-Cantalejo Padial, Ignacio Oulego-Erróz, Laia Vega Puyal, Daniel Moreno, Emilia Fernández Romero, María García Besteiro, J.C. González, Carmen Medina Monzón, Beatriz Huidobro Labarga, Rosa María Hernández Palomo, Cristina Calvo Monge, Francisco Arnalich, Nieves González, César Villa Francisco, Lorena Bermúdez Barrezueta, Ana Abril Molina, Mónica Valerón, Ramón Hernández Rastrollo, Sylvia Belda Hofheinz, Manuel Gijón Mediavilla, José Luís Vázquez Martínez, Manuel Frías, Raúl Montero Yéboles, J.I. Muñoz Bonet, Maria Jose Martinez Velázquez, Inma Sánchez Ganfornina, Antonio Pérez Iranzo, David Lozano‐Paniagua, Clara Sorribes, M.S. Holanda Peña, Miriam Gutiérrez-Jimeno,
Tópico(s): Respiratory Support and Mechanisms
2020 - Springer Science+Business Media | Intensive Care Medicine