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Artigo Revisado por pares

Juan José Soler‐Cataluña, Pascual Piñera, Juan Antonio Trigueros, Myriam Calle, Ciro Casanova, Borja G. Cosío, José Luís López-Campos, Jesús Molina, Pere Almagro, José-Tomás Gómez, Juan Antonio Riesco, Pere Simonet, David Rigau, Joan B. Soriano, Julio Ancochea, Marc Miravitlles,

This article details the GesEPOC 2021 recommendations on the diagnosis and treatment of COPD exacerbation syndrome (CES). The guidelines propose a definition-based syndromic approach, a new classification of severity, and the recognition of different treatable traits (TT), representing a new step toward personalized medicine. The evidence is evaluated using GRADE methodology, with the incorporation of 6 new PICO questions. The diagnostic process comprises four stages: 1) establish a diagnosis of CES, ...

Tópico(s): Pleural and Pulmonary Diseases

2022 - Elsevier BV | Archivos de Bronconeumología

Artigo Revisado por pares

Juan José Soler‐Cataluña, Pascual Piñera, Juan Antonio Trigueros, Myriam Calle, Ciro Casanova, Borja G. Cosío, José Luís López-Campos, Jesús Molina, Pere Almagro, José-Tomás Gómez, Juan Antonio Riesco, Pere Simonet, David Rigau, Joan B. Soriano, Julio Ancochea, Marc Miravitlles,

This article details the GesEPOC 2021 recommendations on the diagnosis and treatment of COPD exacerbation syndrome (CES). The guidelines propose a definition-based syndromic approach, a new classification of severity, and the recognition of different treatable traits (TT), representing a new step toward personalized medicine. The evidence is evaluated using GRADE methodology, with the incorporation of 6 new PICO questions. The diagnostic process comprises four stages: 1) establish a diagnosis of CES, ...

Tópico(s): Pleural and Pulmonary Diseases

2021 - Elsevier BV | Archivos de Bronconeumología

Artigo Acesso aberto Revisado por pares

Emilio Rodrigo, Lídia Santos, Celestino Piñera, Juan Carlos Ruiz, Maria Estrella Quintela, Carmen Toyos, Natalia Allende, C. Gómez-Alamillo, Manuel Arias,

Our aim was to analyze the performance of two scores developed for predicting diabetes in nontransplant populations for identifying kidney transplant recipients with a higher new-onset diabetes mellitus after transplantation (NODAT) risk beyond the first year after transplantation.We analyzed 191 kidney transplants, which had at least 1-year follow-up posttransplant. First-year posttransplant variables were collected to estimate the San Antonio Diabetes Prediction Model (SADPM) and Framingham Offspring ...

Tópico(s): Folate and B Vitamins Research

2012 - American Diabetes Association | Diabetes Care

Artigo Revisado por pares

Olivia García‐Suárez, M.G. Calavia, Francisco J. Pérez-Moltó, Covadonga Álvarez‐Abad, Pablo Pérez‐Piñera, Juan Manuel Dieste Cobo, José A. Vega,

To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery.We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial ...

Tópico(s): Lipid Membrane Structure and Behavior

2010 - Lippincott Williams & Wilkins | Pancreas

Artigo Revisado por pares

J.A Montano, M.G. Calavia, Olivia García‐Suárez, J. A. Suárez-Quintanilla, Adriana Galvez, Pablo Pérez‐Piñera, Juan Cobo, José A. Vega,

Pacinian corpuscles are innervated by large myelinated Aα-β axons from the large- and intermediate-sized sensory neurons of dorsal root ganglia. These neurons express different members of the degenerin/epithelial Na+ channel (DEG/ENa+C) superfamily of proteins with putative mechanosensory properties, whose expression is regulated by the TrkB–BDNF system. Thus, we hypothesized that BDNF and/or NT-4 signalling through activation of TrkB may regulate the expression of molecules supposed to be necessary ...

Tópico(s): Ion Channels and Receptors

2009 - Elsevier BV | Neuroscience Letters

Artigo Revisado por pares

M.G. Calavia, Jorge Feito, L. López-Iglesias, Félix de Carlos Villafranca, Olivia García‐Suárez, Pablo Pérez‐Piñera, Juan Cobo, José A. Vega,

Cutaneous Meissner corpuscles depend for development and survival exclusively on the NT system TrkB/BDNF/NT-4 unlike other types of sensory corpuscles and nerve endings, which have very complex neuronal and growth factor dependence. However, the pattern of expression of TrkB in human Meissner corpuscles is not known. The experiments in these studies were designed to pursue further findings that suggest that BDNF and NT-4 have critical roles in the development and maintenance of Meissner corpuscles ...

Tópico(s): Skin and Cellular Biology Research

2009 - Elsevier BV | Neuroscience Letters

Artigo Acesso aberto Revisado por pares

Manuel Arias, R Escallada, Ángel L.M. de Francisco, Emilio Rodrigo, Gema Fernández‐Fresnedo, Ma ÁNgeles Setien, Celestino Piñera, Juan Carlos Ruiz, I Herráez, J.G Cotorruelo,

Return to dialysis after renal transplantation. Which would be the best way? The exact moment to return to dialysis when a graft fails has not clearly been established. Furthermore, there is no agreement with respect to whether the guidelines accepted for patients entering dialysis for the first time are adequate for this subgroup of patients with advanced renal failure, due to the special characteristics of these patients, derived from the immunosuppressive medications they are taking among other ...

Tópico(s): Neurological Complications and Syndromes

2002 - Elsevier BV | Kidney International

Carta Acesso aberto Revisado por pares

R. Palomar, Pablo Morales, S. Castro, A. Tasis, Emilio Rodrigo, Celestino Piñera, Juan Carlos Ruiz, Gema Fernández‐Fresnedo, A. L. Martin de Francisco, M. Arias,

Pleural effusion secondary to minoxidil in a peritoneal dialysis patient

Tópico(s): Pneumothorax, Barotrauma, Emphysema

2004 - Oxford University Press | Nephrology Dialysis Transplantation

Artigo Acesso aberto

Òscar Miró, Aitor Alquézar‐Arbé, Pere Llorens, Francisco Javier Martín‐Sánchez, Sònia Jiménez, Alfonso Martı́n, Guillermo Burillo–Putze, Javier Jacob, Eric Jorge García-Lamberetchs, Pascual Piñera, Juan González del Castillo,

To describe and compare the demographic characteristics and comorbidities of patients with COVID-19 who died in Spanish hospitals during the 2020 pandemic based on whether they were or were not admitted to an intensive care unit (ICU) prior to death. We performed a secondary analysis of COVID-19 patients who died during hospitalization included by 62 Spanish emergency departments in the SIESTA cohort. We collected the demographic characteristics and comorbidities, determined both individually and ...

Tópico(s): Family and Patient Care in Intensive Care Units

2020 - Elsevier BV | Medicina Intensiva (English Edition)

Artigo Revisado por pares

Marc Miravitlles, Juan José Soler‐Cataluña, Myriam Calle, Jesús Molina, Pere Almagro, José Antonio Quintano, Juan Antonio Riesco, Juan Antonio Trigueros, Pascual Piñera, Adolfo Simón, Juan Luis Rodríguez Hermosa, Ester Marco, Daniel López, Ramón Coll, Roser Coll-Fernández, Miguel Ángel Lobo, Jesús Díez‐Manglano, Joan B. Soriano, Julio Ancochea,

Chronic obstructive pulmonary disease (COPD), a very common disease, is the third leading cause of death worldwide. Due to the significant heterogeneity of clinical phenotypes of COPD there is no single method suitable for predicting patients' health status and outcomes, and therefore multidimensional indices, assessing different components of the disease, were developed and are recommended for clinical practice by international guidelines. Several indices have been widely accepted: BODE and its ...

Tópico(s): Nursing Diagnosis and Documentation

2014 - Elsevier BV | Archivos de Bronconeumología

Artigo Acesso aberto Revisado por pares

Marc Miravitlles, Juan José Soler‐Cataluña, Myriam Calle, Jesús Molina, Pere Almagro, José Antonio Quintano, Juan Antonio Trigueros, Pascual Piñera, Adolfo Simón, Juan Antonio Riesco, Julio Ancochea, Joan B. Soriano,

After the development of the COPD Strategy of the National Health Service in Spain, all scientific societies, patient organisations, and central and regional governments formed a partnership to enhance care and research in COPD. At the same time, the Spanish Society of Pneumology and Thoracic Surgery (SEPAR) took the initiative to convene the various scientific societies involved in the National COPD Strategy and invited them to participate in the development of the new Spanish guidelines for COPD ( ...

Tópico(s): Respiratory and Cough-Related Research

2013 - Springer Nature | Primary Care Respiratory Journal

Artigo Acesso aberto Revisado por pares

José Luis Górriz, Pablo Molina, M. Jesús Cerverón, R Vilà, Jordi Bover, Javier Nieto, Guillermina Barril, Alberto Martínez‐Castelao, Elvira Fernández, Verónica Escudero, Celestino Piñera, Teresa Adragão, Juan F. Navarro‐González, Luis-Miguel Molinero, Cristina Castro-Alonso, Luis Pallardó, Sophie A. Jamal,

Background and objectives Vascular calcification (VC) is common in CKD, but little is known about its prognostic effect on patients with nondialysis CKD. The prevalence of VC and its ability to predict death, time to hospitalization, and renal progression were assessed. Design, setting, participants, & measurements The Study of Mineral and Bone Disorders in CKD in Spain is a prospective, observational, 3-year follow-up study of 742 patients with nondialysis CKD stages 3–5 from 39 centers in Spain from ...

Tópico(s): Trace Elements in Health

2015 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology

Artigo Acesso aberto Revisado por pares

Òscar Miró, Aitor Alquézar‐Arbé, Pere Llorens, Francisco Javier Martín‐Sánchez, Sònia Jiménez, Alfonso Martı́n, Guillermo Burillo–Putze, Javier Jacob, Eric Jorge García‐Lamberechts, Pascual Piñera, Juan González del Castillo,

Describir las características demográficas y de comorbilidad de los pacientes con COVID-19 fallecidos en hospitales españoles durante el brote pandémico de 2020 y compararlas según si ingresaron o no en una Unidad de Cuidados Intensivos (UCI) antes del fallecimiento. Análisis secundario de los pacientes de la cohorte SIESTA (formada por pacientes COVID de 62 hospitales españoles) fallecidos durante la hospitalización. Se recogieron sus características demográficas y comorbilidades, individuales y ...

Tópico(s): Family and Patient Care in Intensive Care Units

2020 - Elsevier BV | Medicina Intensiva

Artigo Revisado por pares

L. Santos, Emilio Rodrigo, Celestino Piñera, Edgar Freitas Quintella, Juan Carlos Ruiz, Gema Fernández‐Fresnedo, R. Palomar, C. Gómez-Alamillo, Angel de Francisco, M. Arias,

New-onset diabetes after transplantation (NODAT), an important complication of renal transplantation leads to reduced graft function and increased patient morbidity and mortality. Because of its high incidence and immense impact on clinical outcomes, prevention of NODAT is highly desirable. Several modifiable and nonmodifiable risk factors for NODAT have been described. The aim of this study was to analyze the influence of various drugs on the development of NODAT during the first year.A retrospective ...

Tópico(s): Diabetes Treatment and Management

2012 - Elsevier BV | Transplantation Proceedings

Artigo Revisado por pares

Emilio Rodrigo, L. Santos, Celestino Piñera, J.A. Quintanar, Juan Carlos Ruiz, Gema Fernández‐Fresnedo, R. Palomar, C. Gómez-Alamillo, M. Arias,

Renal transplant recipients are at high risk of cardiovascular disease (CVD). New-onset diabetes mellitus after transplantation (NODAT) contributes to the risk of CVD, reducing graft and patient survival. To improve outcome of kidney transplant recipients, it is of great interest to identify those patients who will develop NODAT. The aim of our study was to explore the predictive value of fifth-day fasting plasma glucose (FPG), third-month proteinuria, and pulse pressure (PP) for NODAT development. ...

Tópico(s): Diabetes Management and Research

2011 - Elsevier BV | Transplantation Proceedings

Revisão Acesso aberto Revisado por pares

J.A Montano, Pablo Pérez‐Piñera, Olivia García‐Suárez, Juan Cobo, José A. Vega,

Abstract Null mutations of genes from the NGF family of NTs and their receptors (NTRs) lead to loss/reduction of specific neurons in sensory ganglia; conversely, cutaneous overexpression of NTs results in skin hyperinnervation and increase or no changes in the number of sensory neurons innervating the skin. These neuronal changes are paralleled with loss of specific types of sensory nerve formations in the skin. Therefore, mice carrying mutations in NT or NTR genes represent an ideal model to identify ...

Tópico(s): Cellular transport and secretion

2009 - Wiley | Microscopy Research and Technique

Artigo Revisado por pares

Antonia M. Jiménez‐Monreal, Francisco J. Aranda, Vicente Micol, Pilar Sánchez‐Piñera, Ana de Godos, Juan C. Gómez‐Fernández,

The activation of protein kinase C α was studied by using a lipid system consisting of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine (POPS) (molar ratio 4:1) and different proportions of 1-palmitoyl-2-oleoyl-sn-glycerol (POG). The phase behavior of the lipidic system was characterized by using differential scanning calorimetry and 31P NMR, and a phase diagram was elaborated. The results suggested the formation of two diacylglycerol/phospholipid ...

Tópico(s): Surfactants and Colloidal Systems

1999 - American Chemical Society | Biochemistry

Artigo Acesso aberto Revisado por pares

Lara Belmar, Emilio Rodrigo Galabia, Jairo Bada da Silva, Marta Bentanachs González, Gema Fernández Fresnedo, Celestino Piñera Haces, Rosa Palomar Fontanet, Juan Carlos Ruiz, Ángel L.M. de Francisco,

Hyperkalaemia is a significant electrolyte imbalance in chronic kidney disease (CKD). Renin-angiotensin-aldosterone system inhibitors (RAASi) have beneficial cardio-renal properties, although they can often cause hyperkalaemia.To examine the prevalence of hyperkalaemia in CKD, identify factors associated with its appearance and the relationship between hyperkalaemia and mortality.Retrospective observational study on patients with CKD in the period 1971-2017. The population was categorised into 3groups: ...

Tópico(s): Electrolyte and hormonal disorders

2019 - Elsevier BV | Nefrología

Artigo Acesso aberto Revisado por pares

Lara Belmar, Emilio Rodrigo Galabia, Jairo Bada da Silva, Marta Bentanachs González, Gema Fernández Fresnedo, Celestino Piñera Haces, Rosa Palomar Fontanet, Juan Carlos Ruiz, Ángel L.M. de Francisco,

Hyperkalaemia is a significant electrolyte imbalance in chronic kidney disease (CKD). Renin–angiotensin–aldosterone system inhibitors (RAASi) have beneficial cardio-renal properties, although they can often cause hyperkalaemia. To examine the prevalence of hyperkalaemia in CKD, identify factors associated with its appearance and the relationship between hyperkalaemia and mortality. Retrospective observational study on patients with CKD in the period 1971–2017. The population was categorised into 3 ...

Tópico(s): Bipolar Disorder and Treatment

2019 - Elsevier BV | Nefrología (English Edition)

Artigo Revisado por pares

A. Solé-Magdalena, Enrique G. Revuelta, Ivan Menénez‐Díaz, M.G. Calavia, Teresa Cobo, Olivia García‐Suárez, Pablo Pérez‐Piñera, Félix de Carlos Villafranca, Juan Cobo, José A. Vega,

Abstract Diverse proteins of the denegerin/epithelial sodium channel (DEG/ENa + C) superfamily, in particular those belonging to the acid‐sensing ion channel (ASIC) family, as well as some members of the transient receptor protein (TRP) channel, function as mechanosensors or may be required for mechanosensation in a diverse range of species and cell types. Therefore, we investigated the putative mechanosensitive function of human odontoblasts using immunohistochemistry to detect ENa + C subunits (α, β, ...

Tópico(s): Ion channel regulation and function

2010 - Wiley | Microscopy Research and Technique

Artigo Acesso aberto Revisado por pares

Pilar Sánchez‐Piñera, Vicente Micol, Senena Corbalán-Garcı́a, Juan C. G. ÓMEZ-FERNÁNDEZ,

The lipid activation of protein kinase C α (PKC α) has been studied by comparing the activation capacity of different 1,2-diacylglycerols and 1,3-diacylglycerols incorporated into mixed micelles or vesicles. Unsaturated 1,2-diacylglycerols were, in general, more potent activators than saturated ones when 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine (POPS)/Triton X-100 mixed micelles and pure POPS vesicles were used. In contrast, these differences were not observed when 1-palmitoyl-2-oleoyl-sn-glycero- ...

Tópico(s): Analytical Chemistry and Chromatography

1999 - Portland Press | Biochemical Journal

Artigo Acesso aberto Revisado por pares

Vicente Micol, Pilar Sánchez‐Piñera, José Villalaı́n, Ana de Godos, Juan C. Gómez‐Fernández,

Lipid activation of protein kinase C α (PKC α) was studied by using a model mixture containing 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoserine (DMPS), and 1,2-dimyristoyl-sn-glycerol (1,2-DMG). This lipid mixture was physically characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and 31P-nuclear magnetic resonance (31P-NMR). Based on these techniques, a phase diagram was constructed by keeping a constant ...

Tópico(s): Protein Kinase Regulation and GTPase Signaling

1999 - Elsevier BV | Biophysical Journal

Artigo Revisado por pares

Miguel Á. Salinero-Fort, Francisco Jesús Arrieta-Blanco, Enrique Carrillo de Santa Pau, Carmen Martín-Madrazo, Marbella Piñera-Tamés, Cristina Vázquez-Martínez, Juan Carlos Abánades-Herranz,

Evaluar el modelo PRECEDE como educación diabetológica, a medio (un año) y largo plazo (dos años), valorando los cambios en el riesgo cardiovascular (RCV) y en los factores de riesgo cardiovasculares de mayor importancia en los pacientes con diabetes tipo 2 (hipertensión arterial, obesidad y lípidos), respecto a los valores iniciales previos a la intervención educativa. La población a estudiar se compuso de un total de 318 pacientes diagnosticados de diabetes tipo 2, a los que se sometió a una educación ...

Tópico(s): Blood Pressure and Hypertension Studies

2009 - Elsevier BV | Revista Clínica Española

Artigo Acesso aberto Revisado por pares

José A. Pacheco de Freitas,

Algo raro pasa.Los presidentes de Ecuador y de Venezuela se abrazan con el nuevo mandatario colombiano.[…] Evo Morales y Alan García no se insultan.Argentina y Uruguay superaron sus diferencias por la papelera.Ecuador y

Tópico(s): Public Policy and Governance

2010 - Pontifical Catholic University of Peru | Agenda Internacional

Artigo Acesso aberto Revisado por pares

Juan Pablo Torres, Cecilia Piñera, Verónica De la Maza, Anne J. Lagomarcino, Daniela Simian, Bárbara Torres, Cinthya Urquidi, Marı́a Teresa Valenzuela, Miguel O’Ryan,

A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak affecting 52 people from a large school community in Santiago, Chile, was identified (12 March) 9 days after the first case in the country. We assessed the magnitude of the outbreak and the role students and staff played using self-administered antibody detection tests and a self-administered survey.The school was closed on 13 March, and the entire community was placed under quarantine. We implemented a home-delivery, self-administered, ...

Tópico(s): SARS-CoV-2 detection and testing

2020 - Oxford University Press | Clinical Infectious Diseases