Book.
1941 - Gale Group | World Scholar Latin America
Tópico(s): Historical and socio-economic studies of Spain and related regions
2019 - Spanish National Research Council | Estudios Geográficos
Oriol Alegre, Françesc Formiga, Ramon López‐Palop, Francisco Marı́n, María Teresa Vidán, Manuel Martínez‐Sellés, Antoni Carol, Alessandro Sionís, Pablo Díez‐Villanueva, Jaime Aboal, Anna Palau-Vendrel, Héctor Bueno, Angel Perez Rivera, Juan Sanchís, Emad Abu‐Assi, Miguel Corbí Santamaría, Juan C. Castillo, Jordi Bañeras, Violeta González‐Salvado, Ángel Cequier, Albert Ariza‐Solé, Oriol Alegre, Albert Ariza‐Solé, Jordi Bañeras, Agnès Rafecas, Cinta Llibre, Miquel Buxons Vives, Alessandro Sionís, Jaime Aboal, Pau Vilardell, Alfredo Bardajı́, Carlos Tomás, Oscar Macho, Manuel Peraire, Ana Lacal, Anna Palau, Vanessa Martínez‐García, Núria Coma, Antoni Carol, Marta Campreciós, Susana Herranz, Sergi Yun, Maria Orriols, Josep Ma Viguer, Juan C. Castillo, Víctor Becerra, Pilar Cardila, Miguel Corbí Santamaría, Javier López, Héctor García‐Pardo, Jose-Ángel Pérez-Rivera, Ana Merino Merino, Francisco Martín‐Herrero, Maria Isabel Garcimartín, Juan Sanchís, Clara Bonanad, Óscar Fabregat, Vícto Pérez-Roselló, Ramon López‐Palop, Miguel Rodríguez-Santamarta, Violeta González‐Salvado, Bernardo García de la Villa, Lluís Asmarats, Jaume Maristany, J. Girós Torres, Marta Gómez-Llorente, Martín J. García‐González, Raquel Pimienta, Ana Viana‐Tejedor, Iván J. Núñez‐Gil, Juan Ruiz-García, Alejandro Cortés Beringola, Héctor Bueno, Manuel Martínez‐Sellés, María Teresa Vidán, Pablo Díez‐Villanueva, Francisco Marı́n, Aitziber Munárriz, N Salterain,
Background Information about the impact of frailty in patients with acute coronary syndromes (ACS) is scarce. No study has assessed the prognostic impact of frailty as measured by the FRAIL scale in very elderly patients with ACS. Methods The prospective multicenter LONGEVO-SCA registry included unselected patients with ACS aged 80 years or older. A comprehensive geriatric assessment was performed during hospitalization, including frailty assessment by the FRAIL scale. The primary endpoint was mortality ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2017 - Elsevier BV | Journal of the American Medical Directors Association
Juan Carlos Moreno‐Brid, Jesús Santamaría, Juan Carlos Rivas Valdivia,
MORE THAN 10 YEARS AGO, MEXICO, THE UNITED STATES AND CANADA LAUNCHED THE NORTH AMERICAN FREE TRADE AGREEMENT (NAFTA). FOR THE MEXICAN GOVERNMENT OF THAT TIME, NAFTA WAS THE COROLLARY OF A RADICAL CHANGE IN THE NATION'S DEVELOPMENT STRATEGY. THIS CHANGE IMPLIED ENDING ONCE AND FOR ALL THE STRATEGY OF IMPORT SUBSTITUTION AND STATE-LED INDUSTRIALIZATION, AND IT WITH A STRATEGY CENTERED ON TRADE LIBERALIZATION AND THE REDUCTION OF STATE INTERVENTION IN THE ECONOMY. IN THE FRAMEWORK OF THIS STRATEGY, ...
Tópico(s): Regional Development and Innovation
2006 - National Autonomous University of Mexico | Economía UNAM
Juan Carlos Moreno‐Brid, Jesús Santamaría, Juan Carlos Rivas Valdivia,
Abstract This article examines Mexico's industrial policy and economic performance, focusing on an analysis of the structural changes in its manufacturing sector associated with NAFTA. The aim of the article is to improve our understanding of why the post‐NAFTA evolution of the Mexican economy has been characterized by lights and shadows, with low inflation, low budget deficits and a surge in non‐oil exports on the one hand, and on the other hand a slower than expected expansion of economic activity ...
Tópico(s): Global Trade and Competitiveness
2005 - Wiley | Development and Change
M. L. García Vivar, Santiago González De Etxabarri, Eva Galíndez Agirregoikoa, Juan Miguel Santamaría,
... SpainSearch for more papers by this authorJuan Miguel Santamaría MD, Juan Miguel Santamaría MD Hospital de Basurto Bilbao, SpainSearch ... SpainSearch for more papers by this authorJuan Miguel Santamaría MD, Juan Miguel Santamaría MD Hospital de Basurto Bilbao, SpainSearch for more ...
Tópico(s): Tuberculosis Research and Epidemiology
1996 - Wiley | Arthritis & Rheumatism
Cristian Rodelo-Haad, M. Victoria Pendón-Ruiz de Mier, Juan Miguel Díaz‐Tocados, Alejandro Martín‐Malo, Rafael Santamaría, Juan R. Muñoz‐Castañeda, Mariano Rodríguez,
Some of the critical mechanisms that mediate CKD progression are associated with vascular calcifications, disbalance of mineral metabolism, increased oxidative and metabolic stress, inflammation, coagulation abnormalities, endothelial dysfunction, or accumulation of uremic toxins. Also, it is widely accepted that pathologies with a strong influence in CKD progression are diabetes, hypertension, and cardiovascular disease. A disbalance in magnesium (Mg) homeostasis, more specifically hypomagnesemia, ...
Tópico(s): Aluminum toxicity and tolerance in plants and animals
2020 - Frontiers Media | Frontiers in Cell and Developmental Biology
José Luis Encinas, A. Luís, L. Avila, F Hernández, Juan C. Sarria, M Gámez, J Murcia, L. Leal, Manuel López‐Santamaría, Juan A. Tovar,
Introduction: The management of children receiving small bowel grafts involves potentially life-threatening complications that affect their nutritional status. The aim of this paper was to define these factors and their influence on nutritional outcome. Patients and Methods: Patients with intestinal failure (IF) who received an isolated small bowel transplantation (SBT) or small bowel/liver transplantation (SBLT) at our hospital during the last 6 years were reviewed for weight Z-score, biochemical ...
Tópico(s): Intestinal Malrotation and Obstruction Disorders
2006 - Thieme Medical Publishers (Germany) | European Journal of Pediatric Surgery
Daniela Baracaldo-Santamaría, Juan Cala-García, Germán José Medina-Rincón, Luis Carlos Rojas-Rodríguez, Carlos‐Alberto Calderón‐Ospina,
Invasive fungal infections are an important cause of morbidity and mortality, especially in critically ill patients. Increasing resistance rates and inadequate antifungal exposure have been documented in these patients, due to clinically relevant pharmacokinetic (PK) and pharmacodynamic (PD) alterations, leading to treatment failure. Physiological changes such as third spacing (movement of fluid from the intravascular compartment to the interstitial space), hypoalbuminemia, renal failure and hepatic ...
Tópico(s): Antibiotic Use and Resistance
2022 - Multidisciplinary Digital Publishing Institute | Antibiotics
María Velayos, Antonio Jesús Muñoz-Serrano, K Estefanía-Fernández, María del Carmen Sarmiento, Lucas Moratilla, Manuel López‐Santamaría, Juan Carlos López‐Gutiérrez,
Acute appendicitis (AA) is the most common abdominal surgical emergency. No specific studies have been found that evaluate the impact of the coronavirus 2 (SARS-Cov-2) pandemic on AA and its surgical management. An analysis was made on the influence of this new pathology on the clinical course of AA.Retrospective observational study was conducted on patients operated on for AA from January to April 2020. They were classified according to the time of the appendectomy, before the declaration of the ...
Tópico(s): COVID-19 and healthcare impacts
2020 - Elsevier BV | Anales de Pediatría (English Edition)
María Velayos, Antonio Jesús Muñoz-Serrano, K Estefanía-Fernández, María del Carmen Sarmiento, Lucas Moratilla, Manuel López‐Santamaría, Juan Carlos López‐Gutiérrez,
Acute appendicitis (AA) is the most common abdominal surgical emergency. No specific studies have been found that evaluate the impact of the coronavirus 2 (SARS-Cov-2) pandemic on AA and its surgical management. An analysis was made on the influence of this new pathology on the clinical course of AA.Retrospective observational study was conducted on patients operated on for AA from January to April 2020. They were classified according to the time of the appendectomy, before the declaration of the ...
Tópico(s): Abdominal Surgery and Complications
2020 - Elsevier BV | Anales de Pediatría
Cristian Rodelo‐Haad, Rafael Santamaría, Juan R. Muñoz‐Castañeda, M. Victoria Pendón-Ruiz de Mier, Alejandro Martín‐Malo, Mariano Rodríguez,
Fibroblast growth factor 23 (FGF23) plays a key role in the complex network between the bones and other organs. Initially, it was thought that FGF23 exclusively regulated phosphate and vitamin D metabolism; however, recent research has demonstrated that an excess of FGF23 has other effects that may be detrimental in some cases. The understanding of the signaling pathways through which FGF23 acts in different organs is crucial to develop strategies aiming to prevent the negative effects associated ...
Tópico(s): Genetic Syndromes and Imprinting
2019 - Multidisciplinary Digital Publishing Institute | Toxins
Andrea J. Santamaría, Juan P. Solano, Francisco Benavides, James D. Guest,
Cell transplant-mediated tissue repair of the damaged spinal cord is being tested in several clinical trials. The current candidates are neural stem cells, stromal cells, and autologous Schwann cells (aSC). Due to their peripheral origin and limited penetration of astrocytic regions, aSC are transplanted intralesionally as compared to neural stem cells that are transplanted into intact spinal cord. Injections into either location can cause iatrogenic injury, and thus technical precision is important ...
Tópico(s): Spinal Cord Injury Research
2018 - Springer Science+Business Media | Methods in molecular biology
Rafael Santamaría, Juan Miguel Díaz‐Tocados, M. Victoria Pendón-Ruiz de Mier, Ana Belén Robles Cruz, M. Dolores Salmerón-Rodríguez, Erena Ruiz, Noemí Vergara, Escolástico Aguilera‐Tejero, Ana I. Raya, Rosa Ortega, Arnold J. Felsenfeld, Juan R. Muñoz‐Castañeda, Alejandro Martín‐Malo, Pedro Aljama, Mariano Rodríguez,
Abstract In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphate intake even in patients with early CKD would result in an excessive load of phosphate causing tubular injury and accelerating renal function deterioration. In CKD 2–3 patients, we evaluated whether increased ...
Tópico(s): Biomedical Research and Pathophysiology
2018 - Nature Portfolio | Scientific Reports
Verónica Fuentes‐Santamaría, Juan Carlos Alvarado, Pedro Melgar–Rojas, María C. Gabaldón-Ull, Josef M. Miller, José M. Juı́z,
Repeated noise exposure induces inflammation and cellular adaptations in the peripheral and central auditory system resulting in pathophysiology of hearing loss. In this study, we analyzed the mechanisms by which noise-induced inflammatory-related events in the cochlea activate glial-mediated cellular responses in the cochlear nucleus (CN), the first relay station of the auditory pathway. The auditory function, glial activation, modifications in gene expression and protein levels of inflammatory ...
Tópico(s): Hearing Loss and Rehabilitation
2017 - Frontiers Media | Frontiers in Neuroanatomy
Karin Neukam, Luís Morano, Antonio Rivero‐Juárez, M.J. Mancebo, Rafael Granados, Francisco Téllez, Antonio Collado, María Rios, Ignacio de los Santos, Sergio Reus, Francisco Jesús Vera-Méndez, Paloma Geijo-Martínez, Marta Montero, Marta Suárez-Santamaría, Juan A. Pineda,
Objective: HIV/HCV-coinfected patients and hepatitis C virus (HCV) monoinfected subjects are thought to respond equally to direct-acting antiviral (DAA)-based therapy despite the lack of data derived from clinical trials. This study is aimed to evaluate the impact of HIV coinfection on the response to DAA-based treatment against HCV infection in the clinical practice.Patients and Methods: In a prospective multicohort study, patients who initiated DAA-based therapy at the Infectious Disease Units of ...
Tópico(s): Hepatitis B Virus Studies
2017 - Taylor & Francis | HIV Clinical Trials
Francisco Salas‐Molina, David Plà-Santamaria, Juan A. Rodríguez-Aguilar,
Cash management is concerned with optimizing costs of short-term cash policies of a company. Different optimization models have been proposed in the literature whose focus has been only placed on a single objective, namely, on minimizing costs. However, cash managers may also be interested in risk associated to cash policies. In this paper, we propose a multi-objective cash management model based on compromise programming that allows cash managers to select the best policies, in terms of cost and ...
Tópico(s): Assembly Line Balancing Optimization
2016 - Springer Science+Business Media | Annals of Operations Research
Ignacio Marcos, José T. San-José, Leire Garmendia, Amaia Santamaría, Juan M. Manso,
Tópico(s): Infrastructure Maintenance and Monitoring
2016 - Elsevier BV | Journal of Cultural Heritage
Darwin Cortés, Julieth Santamaría, Juan F. Vargas,
In November 2008, Colombian authorities dismantled a network of Ponzi schemes, making hundreds of thousands of investors lose tens of millions of dollars throughout the country. Using original data on the geographical incidence of the Ponzi schemes, this paper estimates the impact of their breakdown on crime. We find that the crash of Ponzi schemes differentially exacerbated crime in affected districts. Confirming the intuition of the standard economic model of crime, this effect is only present ...
Tópico(s): Cybercrime and Law Enforcement Studies
2016 - Elsevier BV | Journal of Economic Behavior & Organization
Marta Skaf, Vanesa Ortega-López, José Antonio de la Fuente Alonso, Amaia Santamaría, Juan M. Manso,
Ladle Furnace Slag (LFS) may be used in substitution of fine aggregate (2–0.063 mm), and filler (<0.063 mm) in bituminous mixtures, considering its suitable particle size and hydraulic properties. From among the range of bituminous mixtures, this research is conducted on Porous Asphalt mixes (PA). Their high void ratio means they can absorb any eventual expansion of the LFS. Mechanical behavior, moisture susceptibility and durability are all tested. The results report the performance of the LFS mixtures, ...
Tópico(s): Innovative concrete reinforcement materials
2016 - Elsevier BV | Construction and Building Materials
Maria Alba Abad, Bethan Medina, Anna Santamaría, Juan Zou, Carla Plasberg-Hill, Arumugam Madhumalar, Uma Jayachandran, Patrick M. Redli, Juri Rappsilber, Erich A. Nigg, A. Arockia Jeyaprakash,
Abstract The ability of kinetochores (KTs) to maintain stable attachments to dynamic microtubule structures (‘straight’ during microtubule polymerization and ‘curved’ during microtubule depolymerization) is an essential requirement for accurate chromosome segregation. Here we show that the kinetochore-associated Ska complex interacts with tubulin monomers via the carboxy-terminal winged-helix domain of Ska1, providing the structural basis for the ability to bind both straight and curved microtubule ...
Tópico(s): DNA Repair Mechanisms
2014 - Nature Portfolio | Nature Communications
Ane Miren Andrés, Almudena Alameda, O. Mayoral, F Hernández, Eva Dominguez, Eva Martinez Ojinaga, Esther Ramos Boluda, Gerardo Prieto, Mónica López-Santamaría, Juan A. Tovar,
To determine HRQOL after pediatric intestinal transplantation. Thirty-four IT survivors from 1999 to 2012 were asked to complete age-specific HRQOL non-disease-specific questionnaires: TAPQOL (0-4 yr), KINDL-R (5-7 yr; 8-12 yr; 13-17 yr), and SF-36v2 (>18 yr), all validated with Spanish population. Primary caregiver completed a SF-36 questionnaire and CBI. Thirty-one participants were included. Median age was 10.2 yr (1-29) and time after transplant 4.4 yr (0-13). Overall patient scores were 78.2 ± 10.6 ( ...
Tópico(s): Palliative Care and End-of-Life Issues
2014 - Wiley | Pediatric Transplantation
Verónica Fuentes-Santamaría, Juan Carlos Alvarado, Diego F López-Muñoz, Pedro Melgar–Rojas, María C. Gabaldón-Ull, José M. Juı́z,
Conductive hearing loss causes a progressive decline in cochlear activity that may result in functional and structural modifications in auditory neurons. However, whether these activity-dependent changes are accompanied by a glial response involving microglia, astrocytes, or both has not yet been fully elucidated. Accordingly, the present study was designed to determine the involvement of glial related mechanisms in the anteroventral cochlear nucleus (AVCN) of adult rats at 1, 4, 7 and 15 d after ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2014 - Frontiers Media | Frontiers in Neuroscience
Verónica Fuentes‐Santamaría, Juan Carlos Alvarado, María C. Gabaldón-Ull, José M. Juı́z,
ABSTRACT One of the main mechanisms used by neurons and glial cells to promote repair following brain injury is to upregulate activity‐dependent molecules such as insulin‐like growth factor 1 (IGF‐1) and interleukin‐1β (IL‐1β). In the auditory system, IGF‐1 is crucial for restoring synaptic transmission following hearing loss; however, whether IL‐1β is also involved in this process is unknown. In this study, we evaluated the expression of IGF‐1 and IL‐1β within neurons and glial cells of the ventral ...
Tópico(s): Hearing Loss and Rehabilitation
2013 - Wiley | The Journal of Comparative Neurology
Verónica Fuentes‐Santamaría, Juan Carlos Alvarado, José M. Juı́z,
Abstract The removal of afferent activity has been reported to modify neuronal activity in the cochlear nucleus of adult rats. After cell damage, microglial cells are rapidly activated, initiating a series of cellular responses that influences neuronal function and survival. To investigate how this glial response occurs and how it might influence injured neurons, bilateral cochlear ablations were performed on adult rats to examine the short‐term (16 and 24 hours and 4 and 7 days) and long‐term (15, ...
Tópico(s): Olfactory and Sensory Function Studies
2012 - Wiley | The Journal of Comparative Neurology
José Luis Encinas, Miguel Ángel García‐Cabezas, James Barkovich, César G. Fontecha, José L. Peiró, Massimo Garriboli, Vı́ctor Borrell, Isabel Reillo, Manuel López‐Santamaría, Juan A. Tovar, Diana L. Farmer,
Tópico(s): Fetal and Pediatric Neurological Disorders
2011 - Elsevier BV | Journal of Pediatric Surgery
Jośe Mondéjar Jiménez, María Cordente-Rodríguez, María Leticia Meseguer Santamaría, Juan Carlos Gázquez–Abad,
Tópico(s): Urban Green Space and Health
2011 - Springer Science+Business Media | International Journal of Environmental Research
Valentí Gómez, Marta Sesé, Anna Santamaría, Juan de Dios Martínez, Elisabeth Castellanos, Marta Soler, Timothy M. Thomson, Rosanna Paciucci,
The lipid raft protein Flotillin-1 was previously shown to be required for cell proliferation. Here we show that it is critical for the maintenance of the levels of the mitotic regulator Aurora B. Knockdown of Flotillin-1 induced aberrant mitotic events similar to those produced by Aurora B depletion and led to a marked decline in Aurora B levels and activity. Transfection of wild-type full-length Flotillin-1 or forms directed to the nucleus increased Aurora B levels and activity. Flotillin-1 interacted ...
Tópico(s): Cellular transport and secretion
2010 - Elsevier BV | Journal of Biological Chemistry
Enric Pastor, Cristina Barrado, Pablo Royo, Eduard Santamaría, Juan López, Esther Salamí,
Forest fires are an important problem for many countries. The economical loss is the most visible impact in the short term. The ecological damage and the impact on the wild life diversity and climate change are the most important factors in the long term. Up to now, satellites like NASA's MODIS (moderate-resolution imaging spectroradiometer) system have been the primary source for strategic large area thermal imaging. Tactical monitoring has been until recently reduced to observation from the ground ...
Tópico(s): UAV Applications and Optimization
2010 - Taylor & Francis | Geocarto International
S Bárrena, F Hernández, Maria Emilia Labadia Miguel, Carlos de la Torre, Ana Moreno, José Luis Encinas, N Leal, J Murcia, L Martínez, M Gámez, Purificación García‐Miguel, Manuel López‐Santamaría, Juan A. Tovar,
Aim of the study was assess the results of the treatment of High-Risk Hepatoblastoma (HRH) in a tertiary center where all liver surgery facilities, including pediatric transplantation (LT), are available.91 primary liver tumors treated between 1991 and 2009 were retrospectively reviewed. HRHs as defined by the SIOP criteria (PRETEXT IV or any stage with venous involvement, extrahepatic disease, tumor rupture and <100 ng/ml serum AFP) were identified and imaging and biopsies were reviewed. The treatment ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2010 - Thieme Medical Publishers (Germany) | European Journal of Pediatric Surgery